indazoles has been researched along with oxadiazoles in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (12.70) | 18.2507 |
| 2000's | 38 (60.32) | 29.6817 |
| 2010's | 14 (22.22) | 24.3611 |
| 2020's | 3 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Hebeiss, K; Kilbinger, H | 1 |
| Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
| Faraci, FM; Sobey, CG | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| Clement, B; Feelisch, M; Kotsonis, P; Schmidt, HH; Siebe, J | 1 |
| Furukawa, T; Katsuragi, T; Kushiku, K; Noguchi, H; Ono, N; Yamada, H; Yamada, K | 1 |
| Chen, G; Ebner, TJ; Iadecola, C; Yang, G | 1 |
| Ekblad, E | 1 |
| Rosenberg, R; Volke, V; Wegener, G | 1 |
| Bicker, G; Seidel, C | 1 |
| Hartell, NA; Reynolds, T | 1 |
| Becker, C; Bergemann, C; Fischer, Y; Graf, B; Hamidizadeh, M; Löken, C | 1 |
| Chai, CY; Su, CK; Wang, Y; Wu, WC | 1 |
| Lee, YC; Martin, E; Murad, F | 1 |
| Fujimura, S; Hisa, H; Nakamura, K; Satoh, S; Suzuki-Kusaba, M; Tanioka, H; Yoshida, M | 1 |
| Bellamy, TC; Garthwaite, J | 1 |
| Hamon, M; Laguzzi, R; Maisonneuve, B; Sévoz-Couche, C | 1 |
| Heiberg, IL; Rosenberg, R; Wegener, G | 1 |
| Jeong, MS; Kim, CJ; Kim, KW; Park, EY; Park, JW; Shin, BS; Shin, MS; Woo, RS; Zhao, RJ | 1 |
| Homer, KL; Wanstall, JC | 1 |
| Furneaux, H; Kloss, S; Mülsch, A | 1 |
| Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP | 1 |
| Browner, NC; Lincoln, TM; Sellak, H | 1 |
| Cury, Y; Picolo, G | 1 |
| Ertunc, M; Onur, R; Sara, Y | 1 |
| Fowler, L; Pearce, B; Watts, J; Whitton, PS | 1 |
| Anctil, M; Pelletier, C; Poulain, I | 1 |
| Boriboun, C; Marks, JD; Wang, J | 1 |
| Bianciotti, LG; di Nunzio, A; Hope, SI; Legaz, G; Morgazo, C; Perfume, G; Vatta, MS | 1 |
| Cheng, JT; Liao, CH; Teng, CM | 1 |
| Bolon, M; Kidder, GM; Lidington, D; McKinnon, RL; Ouellette, Y; Tyml, K | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Chlopicki, S; Lomnicka, M; Marcinkiewicz, E; Motterlini, R; Olszanecki, R | 1 |
| Carletti, F; D'Agostino, S; Ferraro, G; Rizzo, V; Sardo, P | 1 |
| Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF | 1 |
| Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM | 1 |
| Grześk, G; Jasiński, M; Masztalerz, M; Piotrowiak, I; Slupski, M; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R; Wlodarczyk, Z | 1 |
| da-Silva, CA; Del Bel, EA; Echeverry, MB; Ferreira, FR; Salgado, ML | 1 |
| Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J | 1 |
| Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S | 1 |
| Del Bel, EA; Echeverry, MB; Guimarães, FS; Iyomasa, M; Spolidório, PC | 1 |
| Rehder, V; Tornieri, K | 1 |
| Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P | 1 |
| Dismuke, WM; Ellis, DZ; Sharif, NA | 1 |
| Del Bel, EA; Issy, AC; Salum, C | 1 |
| Agar, A; Akpinar, D; Savcioglu, F; Yargicoglu, P | 1 |
| Sammut, S; Threlfell, S; West, AR | 1 |
| Cosgrave, AS; McKay, JS; Thippeswamy, T | 1 |
| Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z | 1 |
| Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS | 1 |
| Balen, Gde O; Budni, J; Fernandes, SC; Freitas, AE; Moretti, M; Rodrigues, AL | 1 |
| Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R | 1 |
| Aricioglu, F; Gacar, N; Gocmez, SS; Komsuoglu-Celikyurt, I; Mutlu, O; Utkan, T | 1 |
| Aricioglu, F; Utkan, T; Yazir, Y | 1 |
| Allain, AV; Kadowitz, PJ; Lasker, GF; Murthy, SN; Pankey, EA; Stasch, JP | 1 |
| Bylina, D; Czeczuk, A; Dziecioł, J; Grześk, E; Grześk, G; Krzyzanowski, M; Malinowski, B; Michalska, A; Sinjab, AT; Szadujkis-Szadurska, K; Wiciński, M | 1 |
| Cervantes-Durán, C; Granados-Soto, V; Murbartián, J; Quiñonez-Bastidas, GN; Rocha-González, HI | 1 |
| Al-Izki, S; Amor, S; Baker, D; Browne, L; Clutterbuck, L; Edith Chan, AW; Garthwaite, J; Gerritsen, WH; Giovannoni, G; Hankey, DJ; Joel, SP; Lidster, K; Montoya, A; Peferoen-Baert, R; Perkins, V; Posada, C; Pryce, G; Selwood, DL; Ummenthum, K; van der Valk, P; von Kutzleben, SM | 1 |
| Akar, F; Bektas, E; Erden, F; Komsuoglu Celikyurt, I; Mutlu, O; Tanyeri, P; Ulak, G | 1 |
| Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M | 1 |
| Aguilar-Valdés, A; Ibarra-Sánchez, MJ; Maravillas-Montero, JL; Martínez-Aguilar, J; Noriega, LG; Sosa-Hernández, VA; Tovar, AR | 1 |
| Fang, L; Gou, S; Liu, Q; Liu, Z; Zhang, B | 1 |
| Binda, C; Catto, M; Delre, P; Gottinger, A; La Spada, G; Latronico, T; Linusson, A; Liuzzi, GM; Mangiatordi, GF; Marchese, S; Mastromarino, M; Miniero, DV; Pisani, L; Rullo, M | 1 |
63 other study(ies) available for indazoles and oxadiazoles
| Article | Year |
|---|---|
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents | 1999 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation.
Topics: Animals; Aorta; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hemeproteins; Indazoles; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 1999 |
Contribution of nitric oxide to the presynaptic inhibition by endothelin ETB receptor of the canine stellate ganglionic transmission.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Antihypertensive Agents; Dogs; Endothelin Receptor Antagonists; Enzyme Inhibitors; Female; In Vitro Techniques; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Stellate Ganglion; Sulfonamides; Synapses; Synaptic Transmission | 1999 |
Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats.
Topics: Animals; Blood Pressure; Brain Stem; Carbon Dioxide; Cerebellar Cortex; Cerebellum; Cerebrovascular Circulation; Electric Stimulation; Enzyme Inhibitors; Glucose; Hyperemia; Indazoles; Laser-Doppler Flowmetry; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Somatosensory Cortex; Tetrodotoxin | 1999 |
Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon.
Topics: Animals; Apamin; Colon; Female; Indazoles; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Tetrodotoxin; Vasoactive Intestinal Peptide | 1999 |
Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo.
Topics: Animals; Arginine; Dopamine; Enzyme Inhibitors; Extracellular Space; Hippocampus; Indazoles; Male; Methylene Blue; Microdialysis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin | 2000 |
Nitric oxide and cGMP influence axonogenesis of antennal pioneer neurons.
Topics: Animals; Axonal Transport; Axons; Cyclic GMP; Dihydrolipoamide Dehydrogenase; Embryo, Nonmammalian; Enzyme Inhibitors; Grasshoppers; Guanylate Cyclase; Horseradish Peroxidase; Indazoles; Morphogenesis; Nervous System; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction | 2000 |
Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD.
Topics: Animals; Arachidonic Acid; Cerebellum; Enzyme Inhibitors; Indazoles; Male; Neuronal Plasticity; Nitric Oxide; Oxadiazoles; Phospholipases A; Phospholipases A2; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission | 2001 |
Inhibition of glucose transport by cyclic GMP in cardiomyocytes.
Topics: Animals; Biological Transport; Cell Hypoxia; Cell Membrane Permeability; Cells, Cultured; Cyclic GMP; Deoxyglucose; Drug Combinations; Female; Glucose Transporter Type 4; Glycolysis; Hydrogen Peroxide; Indazoles; Insulin; Microscopy, Confocal; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oligomycins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Rotenone | 2001 |
The nNOS/cGMP signal transducing system is involved in the cardiovascular responses induced by activation of NMDA receptors in the rostral ventrolateral medulla of cats.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; Heart Rate; Hypertension; Indazoles; Male; Medulla Oblongata; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2001 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Facilitatory role of NO in neural norepinephrine release in the rat kidney.
Topics: Animals; Benzoates; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indazoles; Kidney; Male; Nervous System; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Oxazines; Perfusion; Pressure; Rats; Rats, Wistar | 2002 |
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Topics: Animals; Cerebellum; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2002 |
Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii.
Topics: Animals; Biguanides; Blood Pressure; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Indazoles; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Reflex; Serotonin; Serotonin Receptor Agonists; Solitary Nucleus; Synaptic Transmission | 2002 |
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Cyclic GMP; Depression; Dimethyl Sulfoxide; Enzyme Inhibitors; Guanylate Cyclase; Imipramine; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Swimming | 2002 |
Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.
Topics: Adolescent; Adult; Arginine; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Ganglionic Stimulants; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Mecamylamine; Methylene Blue; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Antagonists; Nitrendipine; Nitric Oxide Synthase; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Purinones; Quinoxalines; Tetrodotoxin; Tritium; Tubocurarine | 2002 |
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction | 2002 |
Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta.
Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Aorta; Base Sequence; Blotting, Northern; Blotting, Western; Cell Nucleus; Cells, Cultured; Dactinomycin; Down-Regulation; ELAV Proteins; ELAV-Like Protein 1; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Molecular Sequence Data; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Oxadiazoles; Oxazines; Poly A; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Soluble Guanylyl Cyclase; Time Factors; Transcription, Genetic; Transfection | 2003 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Humans; Indazoles; Interleukin-1; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroso Compounds; Nucleotides, Cyclic; Oxadiazoles; Quinoxalines; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2004 |
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Crotalid Venoms; Crotalus; Dinoprostone; Drug Antagonism; Enzyme Inhibitors; Hyperalgesia; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2004 |
The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Endotoxemia; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indazoles; Lipopolysaccharides; Male; Muscle Contraction; Neuromuscular Nondepolarizing Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Ryanodine; Tubocurarine; Vasodilator Agents; Verapamil | 2004 |
Release of arginine, glutamate and glutamine in the hippocampus of freely moving rats: Involvement of nitric oxide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Hippocampus; Indazoles; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Wakefulness | 2005 |
Nitric oxide modulates peristaltic muscle activity associated with fluid circulation in the sea pansy Renilla koellikeri.
Topics: Animals; Anthozoa; Body Fluids; California; Guanidines; Immunohistochemistry; Indazoles; Muscle Contraction; Muscles; Neurites; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peristalsis; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2005 |
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
Topics: Animals; Animals, Newborn; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Clonazepam; Hippocampus; Indazoles; Ion Transport; Mitochondria; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Oxygen; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ruthenium Compounds; Thiazepines | 2005 |
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase | 2005 |
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors | 2005 |
Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO.
Topics: Animals; Arterioles; Bacterial Infections; Blotting, Western; Connexins; Gap Junction alpha-4 Protein; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Vasoconstriction | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
Topics: Analysis of Variance; Blood Platelets; Carbon Monoxide; Collagen; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide Donors; Organometallic Compounds; Oxadiazoles; Penicillamine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Spectrophotometry; Statistics, Nonparametric; Thrombin; Time Factors | 2006 |
Involvement of nitric oxide-soluble guanylyl cyclase pathway in the control of maximal dentate gyrus activation in the rat.
Topics: Animals; Arginine; Dentate Gyrus; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Iontophoresis; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2006 |
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines | 2007 |
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides | 2007 |
Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Topics: Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indazoles; Kidney Transplantation; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Organ Preservation; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Retrospective Studies; Vasodilation; Vasodilator Agents | 2007 |
Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice.
Topics: Animals; Arginine; Behavior, Animal; Catalepsy; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Injections, Intraventricular; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors | 2007 |
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation | 2007 |
Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus.
Topics: Analysis of Variance; Animals; Anxiety; Cyclic GMP; Dentate Gyrus; Dose-Response Relationship, Drug; Guanylate Cyclase; Hippocampus; Indazoles; Male; Maze Learning; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Punishment; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2007 |
Nitric oxide release from a single cell affects filopodial motility on growth cones of neighboring neurons.
Topics: Analysis of Variance; Animals; Cell Communication; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Invertebrate; Growth Cones; Helix, Snails; Indazoles; Neurons; Nitric Oxide; Oxadiazoles; Pseudopodia; Time Factors | 2007 |
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork | 2009 |
Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice.
Topics: Animals; Auditory Perception; Clozapine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; Haloperidol; Indazoles; Male; Methylphenidate; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Reflex, Startle | 2009 |
The effect of heme oxygenase inhibition on visual evoked potentials.
Topics: Animals; Arsenites; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Evoked Potentials, Visual; Heme Oxygenase (Decyclizing); Indazoles; Male; Metalloporphyrins; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Compounds; Visual Pathways | 2009 |
Nitric oxide-soluble guanylyl cyclase signaling regulates corticostriatal transmission and short-term synaptic plasticity of striatal projection neurons recorded in vivo.
Topics: Action Potentials; Analysis of Variance; Animals; Biophysics; Corpus Striatum; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Frontal Lobe; Guanylate Cyclase; Indazoles; Male; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Neurons; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Synaptic Transmission; Time Factors | 2010 |
Differential regulation of vasoactive intestinal peptide (VIP) in the dentate gyrus and hippocampus via the NO-cGMP pathway following kainic acid-induced seizure in the rat.
Topics: Animals; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Indazoles; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2010 |
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling | 2011 |
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic | 2011 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones | 2011 |
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea | 2011 |
Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats.
Topics: Animals; Arginine; Avoidance Learning; Cognition; Guanylate Cyclase; Indazoles; Male; Memory; Memory, Short-Term; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Retention, Psychology; Soluble Guanylyl Cyclase | 2011 |
Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Cyclic GMP; Depression; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Indazoles; Male; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Stress, Psychological; Swimming | 2012 |
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors | 2013 |
Imidazole-induced contractility of vascular smooth muscle cells in the presence of U-73122, ODQ, indomethacin and 7-nitroindazole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enzyme Inhibitors; Estrenes; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasoconstriction | 2013 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glyburide; Hyperalgesia; Indazoles; Methiothepin; Naloxone; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pain Measurement; Piperazines; Piperidones; Pyridines; Quinoxalines; Rats; Spiro Compounds | 2013 |
Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Biological Specimen Banks; Brain; Carbamazepine; Carrier Proteins; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental; Female; Immunohistochemistry; Indazoles; Mass Spectrometry; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Optic Neuritis; Oxadiazoles; Sodium Channel Blockers; T-Lymphocytes; Uveitis; Voltage-Gated Sodium Channels | 2014 |
Effects of 7-NI and ODQ on memory in the passive avoidance, novel object recognition, and social transmission of food preference tests in mice.
Topics: Animals; Anxiety; Arginine; Avoidance Learning; Exploratory Behavior; Food Preferences; Indazoles; Male; Memory; Mice; Mice, Inbred BALB C; Motor Activity; Oxadiazoles; Quinoxalines; Smell; Social Behavior | 2014 |
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2016 |
SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition.
Topics: Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Humans; Indazoles; Mass Spectrometry; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proteome; Proteomics; Signal Transduction; Sulfonamides | 2021 |
Blood-Brain Barrier Permeable and NO-Releasing Multifunctional Nanoparticles for Alzheimer's Disease Treatment: Targeting NO/cGMP/CREB Signaling Pathways.
Topics: Alzheimer Disease; Animals; Apoptosis; Cell Line, Tumor; Donepezil; Drug Carriers; Drug Liberation; Humans; Indazoles; Male; Memory; Mice, Inbred BALB C; Mice, Nude; Multifunctional Nanoparticles; Neuronal Plasticity; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nootropic Agents; Oxadiazoles; Purines; Pyrazoles; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.
Topics: Humans; Hydrogen Peroxide; Indazoles; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotection; Oxadiazoles; Structure-Activity Relationship | 2023 |