indazoles has been researched along with lonidamine in 316 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (28.16) | 18.7374 |
| 1990's | 109 (34.49) | 18.2507 |
| 2000's | 44 (13.92) | 29.6817 |
| 2010's | 53 (16.77) | 24.3611 |
| 2020's | 21 (6.65) | 2.80 |
| Authors | Studies |
|---|---|
| Kimura, I; Kiura, K; Ohnoshi, T; Segawa, Y; Shibayama, T; Tabata, M; Takigawa, N; Ueoka, H | 1 |
| Capua, A; De Fabritiis, P; Leonetti, C; Mandelli, F; Sandrelli, A; Zupi, G | 1 |
| Barcellona, PS; Heywood, R; Patton, DS | 1 |
| Costa, A; Orlandi, L; Silvestrini, R; Villa, R; Zaffaroni, N | 1 |
| Amadori, A; Amadori, D; Flamigni, A; Frassineti, GL; Magni, E; Nanni, O; Savini, S; Volpi, A; Zoli, W | 1 |
| Boccardo, F; Decensi, A; Guarneri, D; Martorana, G; Oneto, F; Pace, M | 1 |
| Christoffel, V; Gatzemeier, U; Lücker, PW; Picollo, R; Toomes, H; Ulmer, J | 1 |
| Frei, E; Teicher, BA | 1 |
| Hahn, GM; Ning, SC | 2 |
| Eble, M; Flentje, M; Hör, A; Latz, D; Wannenmacher, M | 1 |
| Bandinelli, E; Cini-Neri, G; Lottini, G; Neri, B | 1 |
| Aitken, SE; Futter, NG; Irvine, AH; Moors, DE; Stewart, DJ | 1 |
| Contu, A; Deriu, A; Olmeo, NA; Ortu, S; Paga, C; Pani, P | 1 |
| Cavalli, F; Gatzemeier, U; Häussinger, K; Kaukel, E; Koschel, G; Martinelli, G; Neuhauss, R; von Pawel, J | 1 |
| Cionini, L | 1 |
| Hardy, JR; Jones, AL; Newell, DR; Smith, IE | 1 |
| Frei, E; Herman, TS; Holden, SA; Teicher, BA | 1 |
| Dezube, B; Frei, E; Herman, TS; Pardee, A; Tanaka, J; Teicher, BA | 1 |
| Citro, G; Cucco, C; Verdina, A; Zupi, G | 1 |
| Button, D; de Graeff, A; Glaholm, J; Leach, MO; Mansi, JL; Newell, DR; Payne, G; Smith, IE | 1 |
| Benassi, M; Cametti, C; Castiglione, S; Floridi, A; Gentile, FP; Indovina, PL; Malorni, W; Santini, MT | 1 |
| Arancia, G; Donelli, G | 1 |
| Canova, N; Casadio, M; Guaraldi, M; Lelli, G; Pannuti, F | 1 |
| Epelbaum, R; Frei, E; Herman, TS; Holden, SA; Liu, SD; Teicher, BA | 1 |
| Danjoux, CE; DeSanctis, AJ; Feeley, MM; Fisher, B; Maroun, J; Martin, L; Raaphorst, GP | 1 |
| Button, D; Catanese, B; Hardy, J; Jenns, K; Mansi, J; Newell, DR; Picollo, R; Smith, IE | 1 |
| Pedrazzoli, P; Robustelli della Cuna, G | 1 |
| Silvestrini, B | 2 |
| Robins, HI | 1 |
| DeGregorio, M; Newton, RE; Paggiarino, DA; Scarantino, CW | 1 |
| Becker, H; Hoffmann, L; Köllermann, M; Müller, W; Possinger, K; Schlichter, A; Schmoll, E; Stahl, M; Wagner, H; Weidenhammer, W | 1 |
| Sales, S; Schiffer, D; Soffietti, R | 1 |
| Classen, S; Flath, B; Kovacs, S; Possinger, K; Wagner, H; Wilmanns, W | 1 |
| Amoroso, D; Gardin, G; Guido, T; Miglietta, L; Pace, M; Pronzato, P; Repetto, L; Rosso, R | 1 |
| Ballatore, P; Calabresi, F; Calabró, A; Curcio, CG; Di Lauro, L; Di Palma, M; Foggi, CM; Giannarelli, D; Marolla, P; Paoletti, G | 1 |
| Dezube, B; Frei, E; Herman, TS; Holden, SA; Tanaka, J; Teicher, BA | 1 |
| Benson, AB; Neuberg, DS; Pandya, KJ; Robins, HI; Tormey, DC | 1 |
| Arcangeli, G; Marini, G; Marpicati, P; Meriggi, F; Montini, E; Simoncini, E; Zaniboni, A | 1 |
| Ciottoli, GB; De Gregorio, M; Kokron, O; Maca, S | 1 |
| Cohen, JD; Lagoni, R; Longo, WL; Neville, AJ; O'Keefe, S; Riggs, C; Robins, HI; Schmitt, CL; Steeves, RA | 1 |
| Weinerman, B | 1 |
| Gabriele, P; Ozzello, F; Sola, B; Tseroni, V | 1 |
| Belmonte, P; Francini, M; Lo Re, G; Monfardini, S; Morassut, S; Tumolo, S; Veronesi, A | 1 |
| Campana, A; D'Onofrio, E; Forster, R; Henderson, L; Mosesso, P; Scorza Barcellona, P | 1 |
| Bagatella, M; Bonardi, G; Calciati, A; Donadio, M; Giaccone, G; Maestroni, F | 1 |
| Albera, C; Gozzelino, F; Pescetti, G; Scagliotti, GV | 1 |
| Brann, TW; Frei, E; Holden, SA; Rosbe, KW; Teicher, BA | 1 |
| Galdieri, M | 1 |
| Caputo, A; Carapella, CM; Cattani, F; Ciottoli, GB; Floridi, A; Iandolo, B; Paggi, MG; Raus, L; Riccio, A | 1 |
| Basurto, C; Bertusi, M; Bisagni, G; Buzzi, F; Di Costanzo, F; Donati, D; Gori, S; Passalacqua, R | 1 |
| Currie, VE; DeAngelis, LM; Farag, FM; Kim, JH; Krol, G; O'Hehir, MA; Posner, JB; Young, CW | 1 |
| Covelli, A; De Fabritiis, P; De Felice, L; Mandelli, F; Pulsoni, A; Sandrelli, A; Simone, F; Zupi, G | 1 |
| Alfieri, AA; He, SQ; Kim, JH; Kim, SH; Young, CW | 1 |
| Delaney, S; Feeley, M; Lobreau, AU; Raaphorst, GP; Szekely, JG | 1 |
| Caputo, A; Del Carlo, C; Fanciulli, M; Floridi, A; Giorno, S; Laudonio, N; Paggi, MG; Silvestrini, B; Zupi, G | 1 |
| Band, P; Murray, N; Shah, A | 1 |
| Ambesi Impiombato, F; Antilli, A; Ciottoli, GB; De Gregorio, M; Del Vecchio, MR; Gallo-Curcio, C; Rinaldi, M; Tonachella, R; Tropea, F; Verturo, I | 1 |
| Cazzulo, JJ; Turrens, JF | 1 |
| Amoroso, D; Bertelli, G; Ciottoli, GB; Conte, PF; Cusimano, MP; Gulisano, M; Lionetto, R; Pronzato, P; Rosso, R | 1 |
| Calio, F; Conti, F; Luparini, MR; Manganaro, M; Miccheli, A; Ricciolini, R | 1 |
| De Martino, C; Floridi, A; Malorni, W; Marcante, ML; Nista, A; Silvestrini, B | 1 |
| Hugander, A; Lagoni, RK; Longo, WL; Neville, AJ; Riggs, C; Robins, HI; Schmitt, CL | 1 |
| Accinni, L; Arancia, G; Cantafora, A; De Martino, C; Malorni, W; Masella, R; Nista, A | 1 |
| Bagnato, A; Bianchi, C; Caputo, A; Floridi, A; Gambacurta, A; Paggi, MG; Silvestrini, B | 1 |
| Caputo, A; Carapella, CM; Del Carlo, C; Fanciulli, M; Floridi, A; Giorno, S; Paggi, MG; Silvestrini, B; Zupi, G | 1 |
| Bagnato, A; Bianchi, C; Caputo, A; Fanciulli, M; Floridi, A; Silvestrini, B | 1 |
| Caputo, A; Fanciulli, M; Floridi, A; Paggi, MG; Perrotti, N; Silvestrini, B; Zeuli, M | 1 |
| Arancia, G; De Martino, C; Giannella, G; Isacchi, G; Malorni, W; Trovalusci, PC | 1 |
| Gerweck, LE; Stryker, JA | 1 |
| Ciottoli, GB; De Gregorio, M; De Luca, B; Greco, S; Magnani, F; Marletta, F; Palmucci, T; Patanè, C; Privitera, G; Tafuri, G | 1 |
| Accinni, L; Arancia, G; De Martino, C; Formisano, G; Malorni, W; Nista, A; Rosati, F; Silvestrini, B | 1 |
| Band, PR; Besner, JG; Coppin, CM; Eisenhauer, EA; Stewart, D; Weinerman, BH | 1 |
| Turrens, JF | 1 |
| Badaracco, G; Bertuzzi, A; Gandolfi, A; Greco, C; Starace, G; Totaro, MD; Vitelli, R; Zupi, G | 1 |
| Caputo, A; Delpino, A; Ferrini, U; Floridi, A; Marcante, ML; Nista, A; Silvestrini, B | 1 |
| Adwankar, MK; Chitnis, MP | 1 |
| Gilchrist, K; Grem, JL; Robins, HI; Trump, DL; Wilson, KS | 1 |
| Band, PR; Coppin, CM; Eisenhauer, EA; Maroun, J; Pritchard, K; Stewart, D; Wilson, K | 1 |
| Adwankar, M; Chitnis, M | 1 |
| Alfieri, AA; Kim, JH; Kim, SH; Young, CW | 1 |
| Caputo, A; Delpino, A; Feriozzi, R; Floridi, A; Marcante, ML; Nista, A; Silvestrini, B | 1 |
| De Martino, C; Galdieri, M; Monaco, L | 1 |
| Hahn, GM; Silvestrini, B; van Kersen, I | 1 |
| Floridi, A; Lehninger, AL | 1 |
| Biglietto, M; Carteni, G; De Cesare, M; Pacilio, G | 1 |
| Caputo, A; Silvestrini, B | 1 |
| Brunner, KW; Cavalli, F; Goldhirsch, A; Joss, RA; Mermillod, B | 1 |
| De Gregorio, M; Palazzo, G; Silvestrini, B | 1 |
| Fabbrini, A; Iapadre, G; Santiemma, V; Tullio, G | 1 |
| Rotin, D; Tannock, IF | 1 |
| Andreani, A; Andreani, F; Bonazzi, D; Bossa, R; Galatulas, I; Rambaldi, M | 1 |
| Cioli, V; Corradino, C; De Martino, C; Pasquini, P; Rossi, V; Silvestrini, B | 1 |
| Dominic, CJ; Singh, SK | 2 |
| De Martino, C; Malorni, W; Marolla, A; Natali, PG; Nista, A; Salsano, F; Viora, M | 1 |
| Band, P; Besner, JG; De Sanctis, A; Deschamps, M; Gervais, P; Leclaire, R; Liverani, L; Mailhot, S | 1 |
| Bellocci, M; Caputo, A; D'Atri, S; De Martino, C; Floridi, A; Marcante, ML; Paggi, MG; Silvestrini, B | 1 |
| Ambrogi, F; Ciottoli, GB; Giannotti, P | 1 |
| Ciottoli, GB; Magno, L; Terraneo, F | 1 |
| Aloe, L; Calabro, A; Carlini, S; Cavaliere, R; Di Filippo, F; Piarulli, L; Varanese, A | 1 |
| Battelli, T; D'Atri, S; De Martino, C; Floridi, A; Gallo, M; Malorni, W; Marcante, ML; Nista, A; Paggi, MG | 1 |
| Alfieri, A; Kim, JH; Kim, SH; Silvestrini, B; Young, CW | 2 |
| Battelli, T; De Gregorio, M; De Martino, C; Ginnetti, A; Giustini, L; Manocchi, P; Mattioli, R; Silvestrini, B | 1 |
| Band, PR; Besner, JG; Catanese, B; De Sanctis, AJ; Deschamps, M; Leclaire, R | 1 |
| Band, PR; Besner, JG; De Sanctis, A; Deschamps, M; Gervais, P; Leclaire, R | 2 |
| Currie, VE; Farag, FM; Kim, JH; Kinahan, JE; O'Hehir, MA; Young, CW | 1 |
| Evans, WK; Mullis, B; Shepherd, FA | 1 |
| Barduagni, A; Barduagni, M; Ciottoli, GB; Delle Chiaie, S; Di Lauro, L; Gallo Curcio, C; Nardi, M; Tonachella, R | 1 |
| Carapella, CM; Delle Chiaie, S; Iandolo, B; Riccio, A | 1 |
| Ciottoli, GB; De Gregorio, M; Kokron, O; Maca, S; Scheiner, W | 1 |
| Cavo, M; Franchi, P; Gobbi, M; Tura, S | 1 |
| Battelli, T; Bellocci, M; Cavaliere, R; De Martino, C; Di Filippo, F; Gallo Curcio, C; Giustini, L; Manocchi, D; Mattioli, R; Rinaldi, M | 1 |
| Bardin, CW; Gunsalus, GL; Lobl, TJ; Musto, NA | 1 |
| Cioli, V; De Martino, C; Hahn, GM; Silvestrini, B | 1 |
| Cioli, V; Citro, G; D'Atri, S; De Martino, C; Feriozzi, R; Floridi, A; Marcante, ML; Menichini, R | 1 |
| Caputo, A; D'Atri, S; De Martino, C; Floridi, A; Marcante, ML; Menichini, R; Nista, A; Silvestrini, B | 1 |
| Caputo, A; De Martino, C; Floridi, A; Marcante, ML; Paggi, MG; Silvestrini, B | 1 |
| Campana, A; De Martino, C; Scorza Barcellona, P; Silvestrini, B | 1 |
| Fawcett, DW; Hilderbrandt-Stark, HE; Mills, JW | 1 |
| Caputo, A | 1 |
| Bellocci, M; De Martino, C; Floridi, A; Malcorni, W; Marcante, ML | 1 |
| De Martino, C; Floridi, A; Marcante, ML; Natali, PG | 1 |
| Bellocci, M; De Martino, C; Floridi, A; Marcante, ML; Paggi, MG | 1 |
| Catanese, B; Segre, G | 1 |
| Hildebrandt-Stark, HE | 1 |
| Barcellona, PS; Campana, A; Cioli, V; Heywood, R; James, RW | 1 |
| Caputo, A; D'Atri, S; De Martino, C; Floridi, A; Marcante, ML; Paggi, MG; Silvestrini, B | 1 |
| Apollonj, C; DeMartino, C; Floridi, A; Marcante, ML; Scorza Barcellona, P; Silvestrini, B | 1 |
| Carpano, S; Conti, F; Di Lauro, L; Giannarelli, D; Gionfra, T; Lopez, M; Paoletti, G; Pignatti, F; Vici, P | 1 |
| Bucci, L; Caponigro, F; Di Martino, N; Facchini, G; Fei, L; Iaffaioli, RV; Mantovani, G; Santangelo, M; Tortoriello, A | 1 |
| Bourgeois, Y; Dutrillaux, B; Magdelénat, H; Miccoli, L; Oudard, S; Poirson, F; Poisson, M; Poupon, MF; Vassault, A | 1 |
| Bardin, CW; Cheng, CY; Grima, J; Mathur, PP; Mo, MY; Panzironi, C; Silvestrini, B | 1 |
| Coptcoat, M; Masters, JR; Popert, RJ; Zupi, G | 1 |
| Ben-Horin, H; Kaplan, O; Navon, G; Tassini, M; Vivi, A | 2 |
| Teicher, BA | 1 |
| Codacci Pisanelli, G; Franchi, F; Giovagnorio, F; Gualdi, G; Guazzugli Bonaiuti, VP; Seminara, P | 1 |
| Buccheri, G; Ferrigno, D | 1 |
| Brunetti, I; Conte, PF; Dargenio, F; Fanucchi, A; Gadducci, A; Giannessi, PG; Muttini, MP | 1 |
| Bearzatto, A; Costa, A; Orlandi, L; Silvestrini, R; Villa, R; Zaffaroni, N | 1 |
| Arancia, G; Calcabrini, A; Citro, G; Meschini, S; Molinari, A | 1 |
| Angelini, F; Ausili Cefaro, GP; Blengio, F; Cirulli, S; Cognetti, F; Colella, E; Giannarelli, D; Lo Russo, V; Merlano, M; Scasso, F | 1 |
| Antonini, G; Arancia, G; Blanck, TJ; Citro, G; Malatesta, F; Meloni, A; Molinari, A; Sarti, P | 1 |
| Nardini, S | 1 |
| Evans, G; McCunniff, AJ; Paggiarino, DA; Scarantino, CW; Young, CW | 1 |
| Bloch, WE; Block, NL; Ferrell, SM; Lokeshwar, BL | 1 |
| Bardelli, D; Bertoni, F; Ciottoli, GB; Magno, L; Rosignoli, MT; Terraneo, F; Tordiglione, M | 1 |
| Ara, G; Eder, JP; Herman, TS; Holden, SA; Korbut, T; Schwartz, GN; Teicher, BA | 1 |
| Cucchiara, T; Flandina, C; Rausa, L; Sanguedolce, R; Varvara, F | 1 |
| Barone, C; Camoriano, A; Gardin, G; Ianniello, G; Merlini, L; Nascimben, O; Naso, C; Pronzato, P; Rosso, M; Rosso, R | 1 |
| Castiglione, S; Fiskum, G; Floridi, A; Kennedy, KA | 1 |
| Benassi, M; Bruno, T; Castiglione, S; Delpino, A; Floridi, A; Gentile, FP; Iacobini, C; Paggi, MG | 1 |
| Berni, F; Calzavara, MP; Cattaneo, MT; D'Adda, D; Filipazzi, V; Frontini, L; Isa, L; Legnani, W; Rho, B; Scapaticci, R | 1 |
| Buccheri, G; Ferrigno, D; Rosso, A | 1 |
| Eapen, L; Evans, WK; Genest, P; Girard, A; Stewart, DJ; Verma, S | 1 |
| De Cesare, M; Pratesi, G; Zunino, F | 1 |
| Cline, JM; Page, RL; Price, GS; Riviere, JE; Thrall, DE | 1 |
| Bottalico, C; de Lena, M; Guerrieri, A; Lorusso, V; Micelli, G; Palmisano, F | 1 |
| Brancaccio, L; Carnicelli, P; Cioffi, R; Comella, P; De Cataldis, G; Ianniello, GP; Lombardi, A; Maiorino, A; Scarpati, MD; Tinessa, V | 1 |
| Alquati, P; Baù, MG; Berruti, A; Bottini, A; Buniva, T; Deltetto, F; Dogliotti, L; Farris, A; Gosso, P; Monzeglio, C; Moro, G; Perroni, D; Sarobba, MG; Sussio, M; Zola, P | 1 |
| Barone, C; Contu, A; Gardin, G; Ianniello, G; Nascimben, O; Pronzato, P; Rosso, R; Sturba, F | 1 |
| Biroccio, A; D'Angelo, C; Del Bufalo, D; Laudonio, N; Sacchi, A; Soddu, S; Zupi, G | 1 |
| Bruno, T; Citro, G; Fanciulli, M; Floridi, A; Valentini, A; Zupi, G | 1 |
| Berg, K; Chekulayev, V; Moan, J; Shevchuk, I | 1 |
| Cheng, YC; Murren, JR; Rappa, G | 1 |
| Cheng, CY; Grima, J; Zhu, L | 1 |
| Askenazy, N; Kaplan, O; Knubovets, T; Kushnir, T; Navon, G | 1 |
| Amadori, D; Gasperi-Campani, A; Roncuzzi, L; Zoli, W | 1 |
| Bearzatto, A; De Marco, C; Gornati, D; Silvestrini, R; Zaffaroni, N | 1 |
| Berruti, A; Dogliotti, L; Gorzegno, G; Tampellini, M | 1 |
| Aravindan, GR; Calcagno, K; Cheng, CY; Chung, S; Grima, J; Lee, WM; Mathur, PP; Mo, MY; Mruk, D; O'Bryan, M; Silvestrini, B; Zhu, LJ | 1 |
| Dell'Antone, P; Piergallini, L | 1 |
| Bottalico, C; Brandi, M; Catino, A; De Lena, M; De Mitrio, A; Gargano, G; Guida, M; Latorre, A; Leone, B; Lorusso, V; Vallejo, C | 1 |
| Borsellino, N; Colucci, G; Gebbia, N; Gebbia, V; Giotta, F; Latteri, MA; Milia, V; Testa, A; Valdesi, M | 1 |
| Chekulayev, V; Chekulayeva, L; Kahru, A; Shevchuk, I | 1 |
| De Cesare, M; Giusti, A; Polizzi, D; Pratesi, G; Zunino, F | 1 |
| Baù, MG; Berruti, A; Bottini, A; Buniva, T; Danese, S; Dogliotti, L; Farris, A; Moro, G; Porcile, G; Richiardi, G; Zola, P | 1 |
| Ben-Yoseph, O; Lyons, JC; Ross, BD; Song, CW | 1 |
| Astone, A; Barone, C; Cassano, A; Colloca, G; Corsi, DC; Fontana, T; Landriscina, M; Noviello, MR; Pozzo, C | 1 |
| Bourgeois, Y; Bras Gonçalves, R; Dutrillaux, B; Miccoli, L; Oudard, S; Poirson-Bichat, F; Poupon, MF; Sureau, F | 1 |
| Dutrillaux, B; Miccoli, L; Oudard, S; Poupon, MF | 1 |
| Bearzatto, A; De Marco, C; Orlandi, L; Silvestrini, R; Villa, R; Zaffaroni, N | 1 |
| Bruno, T; Fanciulli, M; Federico, A; Floridi, A; Miccadei, S; Paggi, MG | 1 |
| Amadori, D; Cariello, S; De Matteis, A; Ferrari, M; Frassineti, GL; Lombardi, A; Mustacchi, G; Nanni, O; Nascimben, O; Santoro, A; Scarpi, E; Zoli, W | 1 |
| Berruti, A; Dogliotti, L; Orlandi, L; Villa, R; Zaffaroni, N | 1 |
| Martelli, S; Palmieri, GF; Wehrlé, P | 1 |
| Bianco, A; Bilancia, D; Carpagnano, F; Cioffi, R; Comella, G; Comella, P; De Cataldis, G; De Lena, M; Di Rienzo, G; Frasci, G; Lorusso, V; Maiorino, L; Manzione, L; Natale, M; Nicolella, G; Pacilio, C; Panza, N | 1 |
| Costantini, P; Goulbern, M; Hirsch, F; Kroemer, G; Marzo, I; Miccoli, L; Petit, PX; Poupon, MF; Ravagnan, L; Reed, JC; Susin, SA; Xie, Z; Zamzami, N | 1 |
| Biroccio, A; Bruno, T; Del Bufalo, D; Fanciulli, M; Floridi, A; Zupi, G | 1 |
| Arancia, G; Guidoni, L; Luciani, AM; Matarrese, P; Rosi, A; Viti, V | 2 |
| D'Ottavio, AM; Fabi, A; Garufi, C; Milella, M; Nisticò, C; Terzoli, E; Vaccaro, A | 1 |
| Cheng, CY; Grima, J; Lee, WM; Li, JC; Samy, ET; Silvestrini, B | 1 |
| Bruno, T; Di Padova, M; Fanciulli, M; Floridi, A; Gentile, FP; Giovannelli, A; Rubiu, O | 1 |
| Cheng, CY; Gong, XD; Leung, GP; Silvestrini, B; Wong, PY; Wong, YL | 1 |
| Ash, E; Cohen, JS; Kaplan, O; Mardor, Y; Ringel, I; Roth, Y; Ruiz-Cabello, J; Sterin, M | 1 |
| Kaplan, O | 1 |
| Cheng, CY; Grima, J | 1 |
| Gong, XD; Wong, PY | 1 |
| Adbel-Haq, H; Gatto, MT; Grippa, E; Leone, MG; Saso, L; Silvestrini, B; Tita, B; Vitalone, A | 1 |
| Caporusso, L; Catino, A; Crucitta, E; De Lena, M; Fanizza, G; Gargano, G; Guida, M; Latorre, A; Lorusso, V; Mazzei, A; Sambiasi, D | 1 |
| Bruey, JM; Corcos, L; Garrido, C; Leroy, I; Lizard, G; Miguet, C; Plenchette, S; Rébé, C; Solary, E; Sordet, O | 1 |
| Belzacq, AS; Brenner, C; Cohen, I; El Hamel, C; Haouzi, D; Kroemer, G; Marchetti, P; Métivier, D; Vieira, HL | 1 |
| Artico, M; Gatto, MT; Saso, L; Tita, B | 1 |
| Auffray, C; Candeil, L; Copois, V; Crabbé, L; Del Rio, M; Gourdier, I; Martineau, P; Mechti, N; Pau, B; Pommier, Y; Ychou, M | 1 |
| Alquati, P; Berruti, A; Bitossi, R; Bonazzi, G; Bottini, A; Bruzzi, P; Bumma, C; Castiglione, F; Danese, S; De Lena, M; De Matteis, A; DeFabiani, E; Dogliotti, L; Farris, A; Giardina, G; Gorzegno, G; Lorusso, V; Moro, G; Nuzzo, F; Sarobba, MG | 1 |
| Fung, KP; Kong, SK; Kwok, TT; Lee, CY; Li, YC; Suen, YK | 1 |
| Burbridge, SM; Gong, X; Lewis, AC; Linsdell, P; Wong, PY | 1 |
| Cheung, KH; Gong, XD; Leung, GP; Linsdell, P; Wong, PY | 1 |
| Cantalamessa, F; Di Martino, P; Martelli, S; Nasuti, C; Palmieri, GF | 1 |
| Disson, O; Hahne, M; Hibner, U; Lerat, H | 1 |
| Cheung, KH; Leung, CT; Leung, GP; Wong, PY | 1 |
| Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Ferretti, G; Papaldo, P | 1 |
| Caiola, M; Gatto, MT; Grippa, E; Persio, D; Saso, L; Tita, B | 1 |
| Andrieu, JM; Banu, E; Carpentier, A; Celerier, D; Delattre, JY; Dutrillaux, B; Fauchon, F; Oudard, S; Poupon, MF | 1 |
| Maeda, H; Rajesh, KG; Sasaguri, S; Suzuki, R | 1 |
| Konovalova, NP | 1 |
| Antimi, M; Barone, C; Botti, C; Cammilluzzi, E; Carlini, P; Conti, F; Cortesi, E; Di Cosimo, S; Di Lauro, L; Fabi, A; Ferretti, G; Giannarelli, D; Lepidini, G; Lopez, M; Marolla, P; Nistico, C; Papaldo, P; Terzoli, E; Vici, P; Vitucci, C | 1 |
| Amadori, D; De Paola, F; Frassineti, GL; Milandri, C; Ricotti, L; Tesei, A; Ulivi, P; Zoli, W | 1 |
| Cheranov, SY; Jaggar, JH | 1 |
| Ando, K; Miyato, Y | 1 |
| Cordelli, E; Eleuteri, P; Guarino, M; Leter, G; Rescia, M; Saso, L; Spanò, M; Traina, ME; Urbani, E | 1 |
| Eleuteri, P; Leter, G; Macrì, C; Mantovani, A; Maranghi, F; Rescia, M; Romeo, A; Saso, L; Spanò, M | 1 |
| Andriole, GL; Bullock, TL | 1 |
| Antimi, M; Botti, C; Carlini, P; Ceribelli, A; Cognetti, F; Cortesi, E; Di Cosimo, S; Di Filippo, F; Di Lauro, L; Ferretti, G; Giannarelli, D; Lopez, M; Marolla, P; Mottolese, M; Naso, G; Nisticò, C; Papaldo, P; Ruggeri, EM; Terzoli, E; Vici, P | 1 |
| Borgne-Sanchez, A; Brenner, C; Deniaud, A; El Dein, OS; Jacotot, E; Kroemer, G; Le Bras, M; Lecellier, G; Lemaire, C; Maillier, E; Rebouillat, D; Touat, Z | 1 |
| Guarino, M; Natoli, A; Romeo, A; Traina, ME; Urbani, E | 1 |
| Gupta, RS; Kachhawa, JB | 1 |
| Chambers, JW; Fowler, ML; Morris, JC; Morris, MT | 1 |
| Cinque, B; Claudi, F; Di Marzio, L; Di Stefano, A; Giorgioni, G; Ruggieri, S; Santoni, G; Sozio, P | 1 |
| Fuchs, AG | 1 |
| Kalia, VK; Prabhakara, S | 1 |
| Amoroso, R; Bartoli, B; Benvenuti, L; Gagliardi, R; Gremigni, V; Lena, A; Rechichi, M; Rossi, L; Salvetti, A; Scarcelli, V; Vecchio, D | 1 |
| Kock, JL; Maartens, MM; Munnik, IA; Ncango, DM; Pohl, CH; Swart, CW; van Wyk, PW | 1 |
| Kalia, VK; Narayanan, V; Prabhakara, S | 1 |
| Borgne-Sanchez, A; Brenner, C; Buron, N; Chen, ZX; Gallerne, C; Jacotot, E; Le Bras, M; Lemaire, C; Lemoine, A; Martel, C; Mayola, E; Pervaiz, S; Sharaf el dein, O; Touat, Z | 1 |
| Aller, P; Calviño, E; de Blas, E; Sánchez, Y; Simón, GP | 1 |
| Amiji, M; Duan, Z; Milane, L | 2 |
| Amiji, M; Duan, ZF; Milane, L | 1 |
| Chae, HJ; Kim, HR; Lee, GH | 1 |
| Aller, P; Boyano-Adánez, Mdel C; Bréard, J; Calviño, E; de Blas, E; Estañ, MC; Sancho, P; Simón, GP | 1 |
| Ristow, M; Schmeisser, S; Zarse, K | 1 |
| Steinman, TI | 1 |
| Darpolor, MM; Glickson, JD; Heitjan, DF; Ho, AM; Lee, SC; Leeper, DB; Nath, K; Nelson, DS; Pickup, S; Zhou, R | 1 |
| Dhar, S; Marrache, S | 1 |
| Ju, RJ; Li, N; Li, XY; Lu, WL; Ma, X; Wang, XX; Zhang, CX; Zhang, L; Zhao, WY; Zhou, J | 1 |
| Bruce, JI; Golding, JP; Kimani, SG; Patrick, L; Phillips, JB; Turner, M; Wardhaugh, T | 1 |
| Gallo, KA; Wu, X | 1 |
| Baltazar, F; Miranda-Gonçalves, V; Morais-Santos, F; Paredes, J; Pinheiro, C; Pinheiro, S; Schmitt, FC; Vieira, AF | 1 |
| Kogan, P; Wald, M | 1 |
| Coss, RA; Kulp, KA; Leeper, DB; Storck, CW; Wahl, M; Wells, TC | 1 |
| Corazzi, L; Davidescu, M; Macchioni, L; Roberti, R | 1 |
| Glickson, JD; Heitjan, DF; Leeper, DB; Nath, K; Nelson, DS; Zhou, R | 2 |
| Aller, P; Boyano-Adánez, Mdel C; Calviño, E; Calvo, S; de Blas, E; Estañ, MC; Guillén-Guío, B; Rial, E | 1 |
| Bartha, R; Li, AX; McVicar, N; Meakin, SO | 1 |
| Cromarty, AD; Joubert, AM; van Tonder, A | 1 |
| Chen, BA; Cui, PF; He, YJ; Jiang, HL; Lyu, JY; Qiao, JB; Wang, FZ; Xie, RL; Xing, L; Zhang, BF; Zhang, JL; Zhang, M | 1 |
| Chu, X; Shao, F; Wang, L | 1 |
| Cervantes-Madrid, D; Dueñas-González, A | 1 |
| Castigli, E; Corazzi, L; Corcelli, A; Cristina Marchetti, M; Davidescu, M; Macchioni, L; Migliorati, G; Roberti, R; Scaramozzino, G; Vitale, R | 1 |
| Cervantes-Madrid, D; Dueñas-González, A; Romero, Y | 1 |
| Assanhou, AG; Kong, L; Li, W; Mo, R; Sun, H; Xue, L; Zhang, C; Zhang, L | 1 |
| Cohen-Erez, I; Rapaport, H | 2 |
| Cheng, CY; Cheng, YH; Geng, K; Liu, T; Quan, Y; Shao, J; Silvestrini, B; Wong, EW; Xia, W; Xie, QR; Yang, X; Zhang, T | 1 |
| Blair, IA; Glickson, JD; Guo, L; Leeper, DB; Nath, K; Nelson, DS; Shestov, AA; Worth, AJ | 1 |
| Blair, IA; Glickson, JD; Guo, L; Halestrap, AP; Leeper, DB; Nancolas, B; Nath, K; Nelson, DS; Zhou, R | 1 |
| Cui, PF; Jiang, HL; Qiao, JB; Wang, FZ; Xing, L; Xu, CX; Zhang, BF; Zhang, JL | 1 |
| Babu, E; Bhutia, YD; Ganapathy, V | 1 |
| Cui, W; Du, H; Hao, J; Li, WW; Liu, F; Lu, JC; Yang, XC; Zhao, ZF | 1 |
| Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME | 1 |
| Blair, IA; Glickson, JD; Guo, L; Halestrap, AP; Lee, SC; Leeper, DB; Nancolas, B; Nath, K; Nelson, DS; Roman, J; Shestov, AA; Zhou, R | 1 |
| Boonmars, T; Cha'on, U; Phoomak, C; Sangkhamanon, S; Seubwai, W; Thamrongwaranggoon, U; Wongkham, S | 1 |
| Hu, X; Liu, H; Pan, T; Tan, R; Tan, W; Wang, S; Wang, Y; Yu, H; Zhong, Z | 1 |
| Bonanomi, M; Mruk, DD; Silvestrini, B | 1 |
| Glickson, JD; Lee, SC; Leeper, DB; Nath, K; Nelson, DS; Putt, ME; Roman, J | 1 |
| Alfranca, G; Cui, D; de la Fuente, JM; Pan, F; Song, J; Yang, Y; Yin, T; Yue, C; Zhang, C; Zhang, Q | 1 |
| Chen, X; Liu, Y; Nan, X; Zhang, X; Zhou, M | 1 |
| Chen, F; Chen, H; Gou, S; Hu, W | 1 |
| Feng, M; Glickson, J; Li, LZ; Lin, Z; Nath, K; Nelson, D; Roman, J; Xu, HN; Zhao, H | 1 |
| Biemans, R; Bussink, J; Dubois, LJ; Meijer, TWH; Peeters, WJM; Span, PN; van Gisbergen, MW; Venhuizen, JH | 1 |
| Fan, H; Feng, J; Feng, T; Ge, L; Lu, Q; Pan, J; Ren, N; Song, G; Tian, R; Wang, L; Wang, S; Xiao, Y; Yi, X; Zhang, X | 1 |
| Chang, AC; Chen, G; Cheng, G; Hardy, M; Kalyanaraman, B; Kresty, L; Lee, Y; Myers, CR; Ouari, O; Pan, J; Weh, K; You, M; Zhang, Q; Zielonka, J; Zielonka, M | 1 |
| Cohen-Erez, I; Gheber, LA; Issacson, C; Laster, B; Lavi, Y; Milam, J; Rapaport, H; Shaco-Levy, R | 1 |
| Jin, X; Lv, H; Zhang, Z; Zhou, J | 1 |
| Choi, HG; Jin, SG; Kim, JO; Ku, SK; Poudel, BK; Ramasamy, T; Ruttala, HB; Ruttala, RRT; Yong, CS | 1 |
| Liu, J; Tang, X; Wu, C; Xu, K; Zhai, Z; Zhong, W | 1 |
| Jing, T; Li, H; Lu, J; Song, X; Xin, Q; Yuan, M | 1 |
| Dueñas-Gonzalez, A; Schcolnik-Cabrera, A | 1 |
| Chen, X; Li, Y; Shi, Y; Su, S; Sun, S; Wang, P | 1 |
| Alcigir, ME; Bakar-Ates, F; Ekim, O; Hascicek, C; Sengel-Turk, CT | 1 |
| Bakar-Ates, F; Ozkan, E | 1 |
| D'Ascenzo, N; Han, S; He, Z; Hu, X; Jacob, C; Liang, X; Liu, Q; Ni, J; Wan, L; Xiao, P; Xiao, W; Xie, Q | 1 |
| Chavez-Blanco, A; Diaz-Chavez, J; Dominguez-Gomez, G; Duenas-Gonzalez, A; Hua, S; Juarez, M; Lai, D; Perez-Montiel, D; Ponce-Toledo, RI; Schcolnik-Cabrera, A; Torres, N; Tovar, AR; Vargas-Castillo, A | 1 |
| Cao, W; Chen, J; Gao, S; Gao, Y; Ju, G; Ren, F; Wu, W; Wu, Z; Xiao, C; Xu, C | 1 |
| Guo, L; Hai, L; Li, R; Lu, J; Peng, Y; Wu, Y; Zhao, Y | 1 |
| Chen, B; Kankala, RK; Krastev, R; Li, X; Liu, Y; Long, R; Wang, P; Wang, S; Xiong, X; Yang, D; Zhang, Y; Zhu, M | 1 |
| Babkov, DA; Gracheva, YA; Kirsanov, KI; Milaeva, ER; Nazarov, AA; Okulova, YN; Ott, I; Redkozubova, OM; Schmidt, C; Shevtsova, EF; Shtil, AA; Shutkov, IA; Sokolova, EV; Spasov, AA; Tyurin, VY | 1 |
| Li, F; Li, H; Li, Z; Sun, L; Wang, X; Weng, J; Xu, W; Zeng, R; Zhang, X; Zhao, S | 1 |
| Guo, L; Hai, L; Li, R; Lu, J; Mu, B; Peng, Y; Shi, Y; Wu, Y; Zhao, Y | 1 |
| Kleszcz, R; Paluszczak, J | 1 |
| Bagnarelli, L; Battocchio, C; De Franco, M; Del Bello, F; Gandin, V; Giorgioni, G; Iucci, G; Marzano, C; Meneghini, C; Pellei, M; Piergentili, A; Quaglia, W; Ramanan, N; Santini, C; Schiesaro, I; Sgarbossa, P; Venditti, I | 1 |
| Du, Y; Hai, L; Li, R; Lu, J; Peng, Y; Shi, Y; Wu, Y; Yang, Z; Zhao, Y; Zhao, Z | 1 |
| Guan, Z; Li, J; Tang, R; Wang, X; Yang, L; Zhang, J | 1 |
| Brabec, V; Gasser, G; Kasparkova, J; Kostrhunova, H; Ma, L; Milaeva, ER; Nazarov, AA; Novohradsky, V; Shtill, AA; Vinck, R; Zhu, G | 1 |
| Calvet, JP; Georg, GI; Jakkaraj, SR; Li, X; Magenheimer, BS; Reif, GA; Sundar, SV; Tash, JS; Wallace, DP; Yu, ASL; Zhou, JX | 1 |
| Aoyama, M; Hirano, H; Ishikawa, K; Nemoto, S; Osada, H; Semba, K; Watanabe, N; Watanabe, S | 1 |
26 review(s) available for indazoles and lonidamine
| Article | Year |
|---|---|
Modulation of antitumor alkylating agents (AA).
Topics: Alkylating Agents; Antineoplastic Agents; Cell Hypoxia; Cisplatin; DNA Damage; DNA Repair; Drug Combinations; Drug Interactions; Drug Resistance; Fluorocarbons; Glutathione; Glutathione Transferase; Humans; Hydroxyethyl Starch Derivatives; Indazoles; Metallothionein; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Topoisomerase II Inhibitors; Xanthines | 1991 |
Radiotherapy plus lonidamine in non-small cell lung cancer.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Humans; Indazoles; Lung Neoplasms | 1991 |
Cell membranes as target for anticancer agents.
Topics: Antineoplastic Agents; Cell Division; Cell Membrane; Doxorubicin; Erythrocyte Membrane; Humans; Indazoles; Lymphocytes; Microscopy, Electron; Neoplasms | 1991 |
Toxicity and clinical tolerance of lonidamine.
Topics: Antineoplastic Agents; Drug Tolerance; Humans; Indazoles | 1991 |
Lonidamine: an overview.
Topics: Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Humans; Indazoles | 1991 |
Combined modality clinical trials for favorable B-cell neoplasms: lonidamine plus whole body hyperthermia and/or total body irradiation.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Humans; Hyperthermia, Induced; Indazoles; Lymphoma, B-Cell; Whole-Body Irradiation | 1991 |
Lonidamine in head and neck cancer: an overview.
Topics: Antineoplastic Agents; Head and Neck Neoplasms; Humans; Indazoles | 1991 |
Lonidamine in malignant brain tumors.
Topics: Antineoplastic Agents; Brain Neoplasms; Glioma; Humans; Indazoles | 1991 |
Lonidamine in metastatic breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Indazoles | 1991 |
Lonidamine, a new approach to cancer therapy.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Diuresis; Female; Indazoles; Kidney; Leukemia P388; Lung Neoplasms; Male; Mitochondria; Oxygen Consumption; Pregnancy; Pyrazoles; Sarcoma 180; Spermatogenesis | 1984 |
New agents in non-small cell lung cancer.
Topics: Adenocarcinoma; Adult; Alkylating Agents; Animals; Anthraquinones; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Humans; Ifosfamide; Indazoles; Lung Neoplasms; Male; Mice; Mitoxantrone; Triazines; Vinblastine; Vindesine | 1984 |
Lonidamine and related compounds.
Topics: Animals; Antineoplastic Agents; Antispermatogenic Agents; Chemical Phenomena; Chemistry; Humans; Indazoles; Kinetics; Pyrazoles | 1984 |
Lonidamine: in vitro/in vivo correlations.
Topics: Antineoplastic Agents; Drug Administration Schedule; Humans; Indazoles; Neoplasms; Tumor Cells, Cultured | 1994 |
Non small cell lung cancer and chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Fluorouracil; Humans; Indazoles; Lomustine; Lung Neoplasms; Methotrexate; Neoplasm Staging; Treatment Outcome | 1994 |
Multifunctional modulators of drug resistance.
Topics: Animals; Bryostatins; Dipyridamole; Drug Resistance, Multiple; Humans; Indazoles; Lactones; Macrolides; Novobiocin; Protein Kinase C | 1996 |
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas].
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Chromosome Deletion; Diazepam; Glioma; Glucose; Glycolysis; Hexokinase; Humans; Indazoles; Mitochondria; Neoplasm Proteins; Porins; Tumor Cells, Cultured | 1998 |
Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.
Topics: alpha-Macroglobulins; Animals; Antineoplastic Agents; Antispermatogenic Agents; Humans; Indazoles; Male; Neoplasms; Proteins; Rats; Testis | 2002 |
Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Female; Humans; Indazoles; Lung Neoplasms; Male; Ovarian Neoplasms; Safety | 2003 |
Emerging drug therapies for benign prostatic hyperplasia.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Antineoplastic Agents; Calcitriol; Cell Proliferation; Drug Therapy, Combination; Enzyme Inhibitors; Finasteride; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Indazoles; Male; Naphthalenes; Phytotherapy; Piperazines; Plant Extracts; Prostatic Hyperplasia; Randomized Controlled Trials as Topic; Receptors, Adrenergic, alpha-1; Serenoa | 2006 |
Polycystic kidney disease: a 2011 update.
Topics: Antineoplastic Agents; Benzazepines; Curcumin; Everolimus; Gastrointestinal Agents; Glomerular Filtration Rate; Humans; Hypertension; Hypoglycemic Agents; Immunosuppressive Agents; Indazoles; Kidney; Metformin; Octreotide; Organ Size; Polycystic Kidney, Autosomal Dominant; Sirolimus; Sodium; Tolvaptan | 2012 |
Male contraception: history and development.
Topics: Administration, Cutaneous; Administration, Oral; Androgens; Animals; Condoms; Contraception; Contraceptive Agents, Male; Diterpenes; Drug Implants; Epoxy Compounds; Ethnicity; Gonadotropin-Releasing Hormone; Gossypol; Humans; Immunologic Techniques; Indazoles; Male; Norethindrone; Phenanthrenes; Progestins; Spermatogenesis; Spermatozoa; Testosterone; Vasectomy | 2014 |
Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Diazooxonorleucine; Humans; Indazoles; Neoplasms | 2015 |
Adjudin--A Male Contraceptive with Other Biological Activities.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Contraceptive Agents, Male; Hair Cells, Auditory; Humans; Hydrazines; Indazoles; Male | 2015 |
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine.
Topics: Antineoplastic Agents; Glycolysis; Humans; Indazoles; Neoplasms; Signal Transduction | 2016 |
Mechanism of antineoplastic activity of lonidamine.
Topics: Animals; Antineoplastic Agents; Hexokinase; Humans; Hydrogen-Ion Concentration; Indazoles; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Monocarboxylic Acid Transporters; Pyruvic Acid | 2016 |
The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance.
Topics: Antineoplastic Agents; Drug Design; Drug Resistance, Neoplasm; Fatty Acids; Humans; Indazoles; Metabolic Engineering; Neoplasms; Oxidative Phosphorylation; Pyruvates | 2017 |
46 trial(s) available for indazoles and lonidamine
| Article | Year |
|---|---|
Phase II study with lonidamine in the treatment of hormone-refractory prostatic cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Drug Evaluation; Humans; Indazoles; Male; Middle Aged; Prostatic Neoplasms | 1992 |
Phase II study of lonidamine in metastatic prostatic carcinoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Drug Evaluation; Humans; Indazoles; Male; Middle Aged; Neoplasm Metastasis; Prostatic Neoplasms | 1991 |
Lonidamine in non-small-cell lung cancer: a phase II study.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Humans; Indazoles; Liver; Lung Neoplasms; Male; Middle Aged | 1991 |
Phase III trial with and without lonidamine in non-small cell lung cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Prospective Studies; Remission Induction; Survival Rate; Time Factors; Vindesine | 1991 |
Lonidamine versus high-dose tamoxifen in progressive, advanced renal cell carcinoma: results of an ongoing randomized phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Evaluation; Female; Humans; Indazoles; Kidney Neoplasms; Male; Middle Aged; Remission Induction; Survival Rate; Tamoxifen; Time Factors | 1991 |
Lonidamine in high-risk breast cancer patients.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged; Remission Induction; Vindesine | 1991 |
Fluorouracil, doxorubicin, and cyclophosphamide versus fluorouracil, doxorubicin, and cyclophosphamide plus lonidamine for the treatment of advanced breast cancer: a multicentric randomized clinical study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Indazoles; Middle Aged; Prospective Studies; Remission Induction; Time Factors | 1991 |
Phase II study of lonidamine in patients with metastatic breast cancer. An Eastern Cooperative Oncology Group study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Drugs, Investigational; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis | 1990 |
Mitomycin-C, vinblastine, and lonidamine as salvage treatment of advanced breast cancer. A pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Indazoles; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Pilot Projects; Vinblastine | 1990 |
Adjunctive therapy (whole body hyperthermia versus lonidamine) to total body irradiation for the treatment of favorable B-cell neoplasms: a report of two pilot clinical trials and laboratory investigations.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Cell Line; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; In Vitro Techniques; Indazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Male; Mice; Mice, Inbred AKR; Middle Aged; Pilot Projects; Pyrazoles; Whole-Body Irradiation | 1990 |
Lonidamine and human lymphoblastoid alpha interferon in metastatic cancer: a phase I study.
Topics: Activities of Daily Living; Adult; Aged; Drug Administration Schedule; Drug Synergism; Female; Humans; Indazoles; Interferon Type I; Male; Middle Aged; Neoplasms | 1990 |
Lonidamine versus polychemotherapy in advanced non-small-cell lung cancer. A preliminary analysis.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Mitomycins; Pyrazoles; Vinblastine | 1989 |
The potential role of lonidamine (LND) in the treatment of malignant glioma. Phase II study.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glioma; Humans; Indazoles; Male; Middle Aged; Neoplasm Recurrence, Local; Pyrazoles | 1989 |
Lonidamine in advanced colorectal cancer: a phase II study of the Italian Oncology Group for Clinical Research (GOIRC).
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Drug Evaluation; Female; Humans; Indazoles; Italy; Male; Middle Aged; Neoplasm Metastasis; Pyrazoles | 1989 |
The combined use of radiation therapy and lonidamine in the treatment of brain metastases.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Female; Humans; Indazoles; Male; Middle Aged; Prospective Studies; Pyrazoles; Randomized Controlled Trials as Topic | 1989 |
Chemotherapy/radiation therapy plus/minus lonidamine in the treatment of non-small cell lung cancer (limited disease): preliminary results.
Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Prospective Studies; Pyrazoles; Random Allocation; Time Factors | 1988 |
Phase II double-blind randomized study of lonidamine and radiotherapy in epidermoid carcinoma of the lung.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Drug Evaluation; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Pyrazoles | 1987 |
Phase II study of lonidamine in patients with metastatic renal cell carcinoma: a National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Indazoles; Kidney Neoplasms; Male; Middle Aged; Nausea; Pain; Pyrazoles; Testis; Testosterone | 1986 |
Lonidamine alone and in combination with other chemotherapeutic agents in the treatment of cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Double-Blind Method; Female; Humans; Indazoles; Male; Middle Aged; Muscles; Pyrazoles; Random Allocation | 1984 |
New agents in non-small cell lung cancer.
Topics: Adenocarcinoma; Adult; Alkylating Agents; Animals; Anthraquinones; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Humans; Ifosfamide; Indazoles; Lung Neoplasms; Male; Mice; Mitoxantrone; Triazines; Vinblastine; Vindesine | 1984 |
Lonidamine plus adriamycin versus adriamycin alone in the adjuvant treatment of recurrent papillary carcinomas of the urinary bladder.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary; Doxorubicin; Eye; Female; Heart; Humans; Indazoles; Male; Middle Aged; Pyrazoles; Urinary Bladder Neoplasms | 1984 |
Intrapatient comparison of single-agent epirubicin with or without lonidamine in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Progression; Drug Resistance, Neoplasm; Epirubicin; Female; Follow-Up Studies; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Survival Rate | 1995 |
Phase II study of high-dose epirubicin, lonidamine, alpha 2b interferon in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Epirubicin; Female; Follow-Up Studies; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indazoles; Interferon alpha-2; Interferon-alpha; Menopause; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Premenopause; Recombinant Proteins | 1995 |
A randomised trial of MACC chemotherapy with or without lonidamine in advanced non-small cell lung cancer. Cuneo Lung Cancer Study Group (CuLCaSG)
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Indazoles; Lomustine; Lung Neoplasms; Male; Methotrexate; Middle Aged; Survival Analysis | 1994 |
Epidoxorubicin and lonidamine in refractory or recurrent epithelial ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Epirubicin; Female; Humans; Indazoles; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Salvage Therapy | 1994 |
Randomised phase II study of methotrexate (MTX) versus methotrexate plus lonidamine (MTX + LND) in recurrent and/or metastatic carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Indazoles; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local | 1994 |
A prospective randomized comparison of radiation therapy plus lonidamine versus radiation therapy plus placebo as initial treatment of clinically localized but nonresectable nonsmall cell lung cancer.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Double-Blind Method; Humans; Indazoles; Lung Neoplasms; Male; Prospective Studies; Radiation-Sensitizing Agents | 1994 |
Double-blind randomized study of lonidamine and radiotherapy in head and neck cancer.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Female; Head and Neck Neoplasms; Humans; Indazoles; Lymphatic Metastasis; Male; Middle Aged; Radiotherapy Dosage; Survival Analysis; Time Factors | 1994 |
The role of lonidamine in the treatment of breast cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged; Survival Analysis | 1993 |
A phase II study of methotrexate, doxorubicin, cyclophosphamide, and lomustine chemotherapy and lonidamine in advanced non-small cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Tolerance; Female; Follow-Up Studies; Humans; Indazoles; Lomustine; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Staging; Pilot Projects; Remission Induction; Survival Rate | 1993 |
Phase II study of lonidamine plus radiotherapy in the treatment of brain metastases.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dexamethasone; Female; Humans; Indazoles; Male; Middle Aged; Muscular Diseases; Pain; Survival Analysis; Treatment Outcome | 1993 |
Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: a multicenter randomized clinical trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Disease Progression; Epirubicin; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Vindesine | 1996 |
Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: results from a multicenter prospective randomized trial.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Synergism; Epirubicin; Female; Humans; Indazoles; Middle Aged; Neoplasm Staging; Prospective Studies; Survival Analysis; Treatment Outcome | 1996 |
Lonidamine plus epirubicin and cyclophosphamide in advanced breast cancer. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Humans; Indazoles; Middle Aged | 1996 |
Revertant and potentiating activity of lonidamine in patients with ovarian cancer previously treated with platinum.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Cisplatin; Drug Synergism; Female; Humans; Indazoles; Middle Aged; Ovarian Neoplasms | 1997 |
Cisplatin and epirubicin plus oral lonidamine as first-line treatment for metastatic breast cancer: a phase II study of the Southern Italy Oncology Group (GOIM).
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Drug Administration Schedule; Epirubicin; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis | 1997 |
Cisplatin, epirubicin, and lonidamine combination regimen as first-line chemotherapy for metastatic breast cancer: a pilot study.
Topics: Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Epirubicin; Female; Humans; Indazoles; Infusions, Intravenous; Middle Aged; Nausea; Pilot Projects; Thrombocytopenia; Treatment Outcome; Vomiting | 1998 |
Treatment of patients with advanced gastric carcinoma with a 5-fluorouracil-based or a cisplatin-based regimen: two parallel randomized phase II studies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Indazoles; Leucovorin; Male; Middle Aged; Prognosis; Quality of Life; Stomach Neoplasms; Survival Analysis; Treatment Outcome | 1998 |
Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: results from a multicenter prospective randomized trial.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Protocols; Doxorubicin; Drug Interactions; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis | 1998 |
Cisplatin, gemcitabine, and vinorelbine combination therapy in advanced non-small-cell lung cancer: a phase II randomized study of the Southern Italy Cooperative Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Disease-Free Survival; Epirubicin; Female; Follow-Up Studies; Gemcitabine; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Proportional Hazards Models; Quality of Life; Vinblastine; Vindesine; Vinorelbine | 1999 |
Weekly epirubicin plus lonidamine in advanced breast carcinoma.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Drug Synergism; Epirubicin; Female; Humans; Indazoles; Injections, Intravenous; Liver Neoplasms; Middle Aged | 1999 |
Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Indazoles; Middle Aged; Ovarian Neoplasms; Paclitaxel; Treatment Outcome | 2001 |
Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Disease Progression; Epirubicin; Female; Humans; Indazoles; Logistic Models; Middle Aged; Survival Analysis | 2002 |
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Diazepam; Female; Glioblastoma; Humans; Indazoles; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Survival Rate | 2003 |
Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Disease-Free Survival; Epirubicin; Female; Filgrastim; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Indazoles; Middle Aged; Recombinant Proteins; Survival Rate | 2003 |
Does granulocyte colony-stimulating factor worsen anemia in early breast cancer patients treated with epirubicin and cyclophosphamide?
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Erythropoiesis; Female; Granulocyte Colony-Stimulating Factor; Humans; Indazoles | 2006 |
245 other study(ies) available for indazoles and lonidamine
| Article | Year |
|---|---|
An adriamycin-resistant subline is more sensitive than the parent human small cell lung cancer cell line to lonidamine.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Cisplatin; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Humans; Indazoles; Lung Neoplasms; Tumor Cells, Cultured | 1992 |
Pharmacological purging of syngeneic bone marrow ex vivo: effect of treatment with doxorubicin and lonidamine on normal and leukaemic cells of DBA/2 mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Purging; Bone Marrow Transplantation; Doxorubicin; Drug Synergism; Indazoles; Leukemia L5178; Male; Mice; Mice, Inbred DBA; Tumor Cells, Cultured | 1992 |
Carcinogenicity assessment of lonidamine by dietary administration to Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Epididymis; Female; Indazoles; Male; Mammary Glands, Animal; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Testis | 1992 |
Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells.
Topics: Cell Cycle; Cell Survival; Cisplatin; Cross-Linking Reagents; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Humans; In Vitro Techniques; Indazoles; Ovarian Neoplasms; Tumor Cells, Cultured | 1992 |
In vitro potentiation by lonidamine of the cytotoxic effect of adriamycin on primary and established breast cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Indazoles; Lethal Dose 50; Male; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured | 1992 |
Single- and multiple dose pharmacokinetics of lonidamine in patients suffering from non-small-cell lung cancer.
Topics: Adult; Aged; Aging; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chromatography, Gas; Chromatography, High Pressure Liquid; Female; Humans; Indazoles; Liver; Lung Neoplasms; Male; Middle Aged | 1991 |
Combination therapy: lonidamine, hyperthermia, and chemotherapy against the RIF-1 tumor in vivo.
Topics: Animals; Antineoplastic Agents; Bleomycin; Carmustine; Combined Modality Therapy; Fibrosarcoma; Fluorouracil; Hyperthermia, Induced; Indazoles; Male; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Sarcoma, Experimental | 1991 |
[Effects of lonidamine alone or in combination with radiotherapy on survival and metabolism in human and rodent cell lines].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; Cricetulus; Humans; Hydrogen-Ion Concentration; Indazoles; Lung Neoplasms; Mice; Mitochondria; Oxidoreductases; Radiotherapy Dosage; Tetrazolium Salts; Tumor Cells, Cultured | 1991 |
Doxorubicin plus lonidamine: in vivo metabolic effects on the rat heart.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Doxorubicin; Drug Synergism; Female; Guanosine Triphosphate; Heart; In Vitro Techniques; Indazoles; Myocardium; Nucleotides; Oxygen Consumption; Rats; Rats, Inbred Strains | 1991 |
Clinical study and pharmacokinetics of lonidamine in advanced non-small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged | 1991 |
Modulation of alkylating agents by lonidamine in vivo.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bone Marrow; Cell Survival; Cisplatin; Cyclophosphamide; Drug Interactions; Fibrosarcoma; Granulocytes; Indazoles; Macrophages; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Thiotepa; Tumor Cells, Cultured | 1991 |
Fluosol-DA/carbogen with lonidamine or pentoxifylline as modulators of alkylating agents in the FSaIIC fibrosarcoma.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bone Marrow; Carbon Dioxide; Cell Survival; Colony-Forming Units Assay; Drug Combinations; Drug Interactions; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Indazoles; Male; Mice; Oxygen; Pentoxifylline | 1991 |
Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line.
Topics: Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; Indazoles; Kinetics | 1991 |
A phase II clinical and pharmacokinetic study of Lonidamine in patients with advanced breast cancer.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Humans; Indazoles; Magnetic Resonance Spectroscopy; Menopause; Middle Aged; Neoplasm Metastasis; Receptors, Estrogen | 1991 |
Effects of lonidamine on the membrane electrical properties of Ehrlich ascites tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Transformation, Neoplastic; Cytosol; Electric Conductivity; Indazoles; Male; Membrane Potentials; Mice; Suspensions; Tumor Cells, Cultured | 1991 |
A phase II study on lonidamine combined with cisplatin and etoposide in the treatment of advanced non-small cell bronchogenic carcinoma (NSCBC).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cisplatin; Drug Evaluation; Etoposide; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Remission Induction | 1990 |
Lonidamine as a modulator of alkylating agent activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carboplatin; Carmustine; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Fibrosarcoma; Humans; Indazoles; Mammary Neoplasms, Animal; Mice; Organoplatinum Compounds; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1991 |
The effect of lonidamine (LND) on radiation and thermal responses of human and rodent cell lines.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Transformed; Cell Survival; Cricetinae; Fibroblasts; Glioma; Humans; Hyperthermia, Induced; Indazoles; Melanoma; Mice; Neoplasms; Radiotherapy; Tumor Cells, Cultured | 1991 |
Lonidamine: an innovative therapy in oncology.
Topics: Antineoplastic Agents; Humans; Indazoles; Neoplasms | 1991 |
The pharmacokinetics of oral lonidamine in breast and lung cancer patients.
Topics: Absorption; Administration, Oral; Aged; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Tolerance; Female; Fluorescence; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Tablets; Time Factors | 1991 |
Etoposide with lonidamine or pentoxifylline as modulators of alkylating agent activity in vivo.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carmustine; Cisplatin; Colony-Forming Units Assay; Cyclophosphamide; Etoposide; Fibrosarcoma; Hematopoietic Stem Cells; Indazoles; Male; Melphalan; Mice; Mice, Inbred C3H; Pentoxifylline; Sarcoma, Experimental | 1991 |
Phase II study of lonidamine in non-small cell lung cancer: final report.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pyrazoles | 1990 |
Cytotoxicity of lonidamine alone and in combination with other drugs against murine RIF-1 and human HT1080 cells in vitro.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Drug Interactions; Drug Screening Assays, Antitumor; Fibrosarcoma; Humans; Indazoles; Kinetics; Mice; Neoplasms, Radiation-Induced | 1990 |
[A case of acinic cell carcinoma of the parotid gland treated with radiotherapy combined with hyperthermia and Doridamine].
Topics: Adult; Carcinoma; Combined Modality Therapy; Female; Humans; Hyperthermia, Induced; Indazoles; Parotid Neoplasms | 1990 |
Partial response to lonidamine of advanced bladder carcinoma: a case report.
Topics: Aged; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Humans; Indazoles; Pyrazoles; Urinary Bladder Neoplasms | 1990 |
Lonidamine: a non-mutagenic antitumor agent.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Chromosome Aberrations; Female; Genes, Dominant; Genes, Lethal; Hypoxanthine Phosphoribosyltransferase; Indazoles; Male; Mice; Micronucleus Tests; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
Chronic administration of lonidamine in untreated non-small cell lung cancer of stage III M0-1.
Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Female; Humans; Indazoles; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Pyrazoles | 1989 |
Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro.
Topics: Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Indazoles; Pyrazoles; Time Factors; Tumor Cells, Cultured | 1989 |
Lonidamine effect on male rat germ cells.
Topics: Animals; Antispermatogenic Agents; Cell Division; Cells, Cultured; Indazoles; Male; Pyrazoles; Rats; Rats, Inbred Strains; Spermatozoa; Thymidine | 1989 |
In vitro pharmacological purging of human bone marrow is enhanced by the use of lonidamine.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bone Marrow; Cell Line; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Indazoles; Lymphoma; Neoplastic Stem Cells; Pyrazoles | 1989 |
Potentiation of radiation effects on multicellular tumor spheroids (MTS) of HeLa cells by lonidamine.
Topics: Cell Aggregation; DNA Repair; HeLa Cells; Humans; Indazoles; Models, Biological; Neoplasms; Pyrazoles; Radiation-Sensitizing Agents | 1989 |
Morphological effects of lonidamine on two human-tumor cell culture lines.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Glioma; Humans; Indazoles; Leukemia, T-Cell; Microscopy, Electron; Microscopy, Electron, Scanning; Organelles; Pyrazoles; Tumor Cells, Cultured | 1989 |
Effect of lonidamine on the utilization of 14C-labeled glucose by human astrocytoma cells.
Topics: Antineoplastic Agents; Brain Neoplasms; Carbon Radioisotopes; Deoxyglucose; Glioblastoma; Glucose; Glycolysis; Humans; Indazoles; Pentose Phosphate Pathway; Pyrazoles; Tumor Cells, Cultured | 1987 |
Phase II study of lonidamine in patients with small cell carcinoma of the lung.
Topics: Adult; Aged; Carcinoma, Small Cell; Drug Evaluation; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Pyrazoles | 1987 |
Inhibition of growth and respiration of Leishmania mexicana by the antitumor agent lonidamine.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Indazoles; Kinetics; Leishmania mexicana; Oxygen Consumption; Pyrazoles | 1987 |
Phase II study of lonidamine in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Pyrazoles | 1989 |
Trypanosoma lewisi: study of the activity of lonidamine in vitro and in vivo in rats.
Topics: Animals; Indazoles; Male; Pyrazoles; Rats; Rats, Inbred F344; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis | 1988 |
Effect of lonidamine on the aerobic glycolysis of normal and phytohemagglutinin-stimulated human peripheral blood lymphocytes.
Topics: Cell Survival; Glycolysis; Hexokinase; Humans; Indazoles; Lactates; Lactic Acid; Lymphocyte Activation; Lymphocytes; Mitochondrial Swelling; Ouabain; Phosphofructokinase-1; Phytohemagglutinins; Pyrazoles | 1985 |
Phase I trial of lonidamine with whole body hyperthermia in advanced cancer.
Topics: Adult; Antineoplastic Agents; Blood Cell Count; Combined Modality Therapy; Drug Evaluation; Female; Humans; Hyperthermia, Induced; Indazoles; Male; Middle Aged; Neoplasms; Pyrazoles | 1988 |
On the mechanism of action of lonidamine: a study on human erythrocyte membrane.
Topics: Cholesterol; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocyte Membrane; Freeze Fracturing; Humans; In Vitro Techniques; Indazoles; Membrane Lipids; Membrane Proteins; Microscopy, Electron, Scanning; Phosphatidylcholines; Pyrazoles; Solubility | 1988 |
Modulation of adriamycin uptake by lonidamine in Ehrlich ascites tumor cells.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Dinitrophenols; Doxorubicin; In Vitro Techniques; Indazoles; Kinetics; Lactates; Male; Mice; Oligomycins; Oxygen Consumption; Pyrazoles | 1988 |
Effect of lonidamine on human malignant gliomas: biochemical studies.
Topics: Astrocytoma; Deoxy Sugars; Deoxyglucose; Glycolysis; Hexokinase; Humans; Indazoles; Lactates; Lactic Acid; Pyrazoles; Tumor Cells, Cultured | 1988 |
Lonidamine-induced membrane permeability and the effect of adriamycin on the energy metabolism of Ehrlich ascites tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Doxorubicin; Energy Metabolism; Indazoles; Pyrazoles | 1988 |
The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine.
Topics: Antineoplastic Agents; Hexokinase; Humans; Indazoles; Mitochondria; Neoplasms; Pyrazoles | 1988 |
Differential effect of lonidamine on the plasma membrane ultrastructure of normal and leukemic human lymphocytes.
Topics: Antineoplastic Agents; B-Lymphocytes; Cell Membrane; Freeze Fracturing; Humans; Indazoles; Leukemia, Lymphoid; Microscopy, Electron; Pyrazoles; Reference Values; T-Lymphocytes | 1988 |
Lonidamine-induced, pH dependent inhibition of cellular oxygen utilization.
Topics: Animals; Antineoplastic Agents; Cell Line; Cricetinae; Hydrogen-Ion Concentration; Indazoles; Mice; Oxygen Consumption; Pyrazoles | 1988 |
Cell membrane changes induced by lonidamine in human erythrocytes and T lymphocytes, and Ehrlich ascites tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Erythrocyte Membrane; Glycolysis; Hexokinase; Humans; Indazoles; Intracellular Membranes; Membrane Proteins; Mice; Microscopy, Electron; Mitochondria; Oxygen Consumption; Pyrazoles; T-Lymphocytes | 1987 |
Inhibitory action of the antitumor agent lonidamine on mitochondrial respiration of Trypanosoma cruzi and T. brucei.
Topics: Animals; Antineoplastic Agents; Hexokinase; Indazoles; Mitochondria; Oxygen Consumption; Pyrazoles; Trypanosoma brucei brucei; Trypanosoma cruzi | 1986 |
Kinetic and survival response of the M14 cell line to lonidamine associated with adriamycin or hyperthermia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Division; Cell Line; Cell Survival; Doxorubicin; Humans; Hyperthermia, Induced; Indazoles; Melanoma; Pyrazoles | 1987 |
Induction of stress proteins by lonidamine in human and murine melanoma cells.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Heat-Shock Proteins; Humans; Indazoles; Melanoma; Mice; Mitochondria; Neoplasm Proteins; Pyrazoles | 1986 |
Modification of tumor cell sensitivity to antineoplastic agents lonidamine and bouvardin (NSC 259968) at elevated temperatures.
Topics: Animals; Antineoplastic Agents; DNA; Drug Resistance; Hyperthermia, Induced; Indazoles; Leukemia P388; Mice; Neoplasms, Experimental; Peptides, Cyclic; Pyrazoles; Sarcoma 180; Thymidine; Tritium | 1986 |
Metastatic Leydig cell tumor of the testis. Report of three cases and review of the literature.
Topics: Adult; Aged; Humans; Indazoles; Leydig Cell Tumor; Male; Middle Aged; Neoplasm Metastasis; Testicular Neoplasms | 1986 |
Phase II study of lonidamine in patients with metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Canada; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Indazoles; Middle Aged; Neoplasm Metastasis; Pyrazoles; Receptors, Estrogen | 1986 |
Potentiation of adriamycin cytotoxicity in P388 murine leukemia sensitive and resistant to adriamycin by use of lonidamine and hyperthermia.
Topics: Animals; Doxorubicin; Drug Resistance; Drug Synergism; Hyperthermia, Induced; Indazoles; Leukemia P388; Leukemia, Experimental; Mice; Pyrazoles; Time Factors | 1986 |
Potentiation of radiation effects on two murine tumors by lonidamine.
Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; Energy Metabolism; Indazoles; Metabolic Clearance Rate; Mice; Neoplasms, Experimental; Pyrazoles; Radiation-Sensitizing Agents; Skin; Time Factors | 1986 |
Effect of lonidamine on protein synthesis in neoplastic cells.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cell-Free System; Dinitrobenzenes; Glycolysis; Humans; Indazoles; Kinetics; Lactates; Leukemia, Experimental; Male; Melanoma; Mice; Neoplasm Proteins; Oligomycins; Pyrazoles; Rabbits; Sarcoma, Experimental | 1985 |
Morphological and biochemical effects of lonidamine on cultured Sertoli cells.
Topics: Animals; Antispermatogenic Agents; Cells, Cultured; Estradiol; Indazoles; Male; Protein Biosynthesis; Pyrazoles; Rats; RNA; Sertoli Cells; Testosterone | 1984 |
Inhibition of the recovery from potentially lethal damage by lonidamine.
Topics: Animals; Bleomycin; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Hot Temperature; Indazoles; Methyl Methanesulfonate; Pyrazoles; Time Factors | 1984 |
Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria.
Topics: Animals; Antineoplastic Agents; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carcinoma, Ehrlich Tumor; Electron Transport; Indazoles; Kinetics; Mice; Mitochondria; Oxygen Consumption; Proton-Translocating ATPases; Pyrazoles | 1983 |
Effects of Lonidamine on pituitary-gonadal axis in man.
Topics: Aged; Antispermatogenic Agents; Follicle Stimulating Hormone; Humans; Indazoles; Luteinizing Hormone; Male; Middle Aged; Pituitary Gland; Prolactin; Pyrazoles; Testis; Thyroid Hormones; Time Factors | 1984 |
The effect of the drug lonidamine on Chinese hamster ovary cells in vitro and on experimental tumors.
Topics: Animals; Antispermatogenic Agents; Cell Line; Cell Survival; Combined Modality Therapy; Cricetinae; Cricetulus; Doxorubicin; Hydrogen-Ion Concentration; Indazoles; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Oxygen; Pyrazoles | 1984 |
Potential antitumor agents, XIII. Indole derivatives related to lonidamine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Female; Indazoles; Mice; Pyrazoles | 1984 |
Pharmacological investigations on lonidamine.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Anticonvulsants; Biogenic Amines; Blood Pressure; Body Temperature; Central Nervous System; Cholagogues and Choleretics; Digestive System; Diuretics; Female; Guinea Pigs; Indazoles; Male; Mice; Pyrazoles; Rats; Spleen; Thymus Gland | 1984 |
Effect of 1-(2, 4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA) on the sex organs of the male laboratory mouse.
Topics: Animals; Antispermatogenic Agents; Genitalia, Male; Indazoles; Male; Mice; Mice, Inbred Strains; Nucleic Acids; Organ Size; Pyrazoles; Spermatogenesis; Spermatozoa; Testis | 1984 |
Inhibition of aerobic glycolysis in normal and neoplastic lymphoid cells induced by Lonidamine [1-(2,4-dichlorobenzyl)-I-H-indazol-3-carboxylic acid].
Topics: Aerobiosis; B-Lymphocytes; Dose-Response Relationship, Drug; Glycolysis; Humans; In Vitro Techniques; Indazoles; Lactates; Lactic Acid; Leukemia; Microscopy, Electron; Phenotype; Pyrazoles; T-Lymphocytes | 1984 |
High-performance liquid chromatography of lonidamine in human plasma and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Indazoles; Pyrazoles | 1983 |
The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cytochrome b Group; Drug Synergism; Electron Transport; Gossypol; Indazoles; Male; Mice; Mitochondria; NAD; NADP; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pyrazoles | 1984 |
Lonidamine. Proceedings of the IInd international symposium, Vancouver 1982.
Topics: Animals; Antineoplastic Agents; Humans; Indazoles; Pyrazoles | 1984 |
Lonidamine and radiotherapy in head and neck cancers. A pilot study.
Topics: Antineoplastic Agents; Female; Head and Neck Neoplasms; Humans; Indazoles; Male; Pyrazoles; Radiation-Sensitizing Agents | 1984 |
Lonidamine and hyperthermia: clinical experience in melanoma. Preliminary results.
Topics: Administration, Oral; Antineoplastic Agents; Humans; Hyperthermia, Induced; Indazoles; Injections, Intra-Arterial; Melanoma; Melphalan; Pyrazoles | 1984 |
Effects of Lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
Topics: Animals; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Indazoles; Lactates; Lactic Acid; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Microscopy, Electron, Scanning; Mitochondria; Neoplasms; Pyrazoles; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Lonidamine: a hyperthermic sensitizer of HeLa cells in culture and of the Meth-A tumor in vivo.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Synergism; Fibrosarcoma; HeLa Cells; Humans; Hyperthermia, Induced; Indazoles; Methylcholanthrene; Mice; Mice, Inbred BALB C; Pyrazoles | 1984 |
Radiosensitization of Meth-A fibrosarcoma in mice by Lonidamine.
Topics: Animals; Antineoplastic Agents; Fibrosarcoma; Indazoles; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Pyrazoles; Radiation Tolerance; Time Factors | 1984 |
A long-term clinical experience with Lonidamine.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Cyclophosphamide; Doxorubicin; Drug Evaluation; Female; Humans; Indazoles; Lomustine; Male; Methotrexate; Middle Aged; Pyrazoles; Tomography, X-Ray Computed | 1984 |
Pharmacokinetics of Lonidamine after oral administration in cancer patients.
Topics: Absorption; Administration, Oral; Adult; Aged; Female; Half-Life; Humans; Indazoles; Kinetics; Male; Middle Aged; Neoplasms; Pyrazoles; Time Factors | 1984 |
Phase I toxicologic study of Lonidamine in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Indazoles; Male; Middle Aged; Neoplasms; Pyrazoles | 1984 |
Phase I and clinical pharmacologic evaluation of Lonidamine in patients with advanced cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Hematopoiesis; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Testis | 1984 |
Phase II study of Lonidamine in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Digestive System; Drug Evaluation; Female; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Time Factors | 1984 |
Phase II evaluation of Lonidamine in patients with advanced malignancy.
Topics: Adult; Aged; Antineoplastic Agents; Auditory Perception; Digestive System; Drug Evaluation; Female; Humans; Indazoles; Lactates; Lactic Acid; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles; Testosterone; Time Factors | 1984 |
Early observations on the administration of Lonidamine in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Digestive System; Drug Administration Schedule; Female; Humans; Indazoles; Male; Middle Aged; Muscles; Neoplasms; Pyrazoles | 1984 |
Lonidamine in primary malignant brain tumors. Preliminary report.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Electrocardiography; Electromyography; Female; Glioma; Humans; Indazoles; Male; Middle Aged; Pyrazoles; Tomography, X-Ray Computed | 1984 |
Phase II study of lonidamine in inoperable non-small-cell lung cancer.
Topics: Aged; Antineoplastic Agents; Digestive System; Drug Evaluation; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged; Muscles; Pyrazoles | 1984 |
Lonidamine in the treatment of chronic lymphoid leukemia.
Topics: Antineoplastic Agents; Cell Survival; Humans; Indazoles; Leukemia, Lymphoid; Lymphocytes; Pyrazoles; Stem Cells | 1984 |
Morphological damage induced in vivo by Lonidamine on human metastatic cancer cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Humans; Hyperthermia, Induced; Indazoles; Melanoma; Mice; Neoplasms; Pyrazoles; Skin Neoplasms | 1984 |
Effects of Lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey.
Topics: Androgen-Binding Protein; Animals; Antispermatogenic Agents; Body Weight; Carrier Proteins; Follicle Stimulating Hormone; Indazoles; Luteinizing Hormone; Macaca mulatta; Male; Organ Size; Pyrazoles; Rats; Sperm Count; Testis; Testosterone; Time Factors | 1981 |
Basic and applied research in the study of indazole carboxylic acids.
Topics: Animals; Antispermatogenic Agents; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fetal Death; Haplorhini; Humans; Indazoles; Lethal Dose 50; Male; Neoplasms, Experimental; Pregnancy; Pyrazoles; Rats; Spermatogenesis; Structure-Activity Relationship | 1981 |
Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Survival; Cricetinae; Cricetulus; Female; Hot Temperature; Humans; Indazoles; Male; Mice; Microscopy, Electron; Mitochondria; Neoplasms, Experimental; Pyrazoles | 1983 |
Energy metabolism of normal and lonidamine-treated Sertoli cells of rats.
Topics: Aerobiosis; Animals; Antispermatogenic Agents; Cells, Cultured; Energy Metabolism; Glucose; Indazoles; Lactates; Lactic Acid; Male; Microscopy, Electron; Oxygen Consumption; Pyrazoles; Rats; Sertoli Cells | 1983 |
Insensitivity of the testis of the musk shrew to DICA.
Topics: Administration, Oral; Animals; Indazoles; Male; Pyrazoles; Shrews; Testis | 1983 |
The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Topics: Aerobiosis; Anaerobiosis; Animals; Carcinoma, Ehrlich Tumor; Dinitrophenols; Dose-Response Relationship, Drug; Energy Metabolism; Glycolysis; Gossypol; Indazoles; Kinetics; Lactates; Male; Mice; Ouabain; Oxygen Consumption; Pyrazoles; Respiration | 1983 |
Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells.
Topics: Animals; Energy Metabolism; Glycolysis; Hexokinase; Indazoles; Lactates; Mice; Mitochondria; Neoplasms, Experimental; Oxygen Consumption; Pyrazoles | 1981 |
The embryotoxicity of a new class of antispermatogenic agents: the 3-indazole-carboxylic acids.
Topics: Animals; Antispermatogenic Agents; Behavior, Animal; Embryo, Mammalian; Female; Fetal Death; Fetus; Gestational Age; Indazoles; Lethal Dose 50; Pregnancy; Pyrazoles; Rats | 1982 |
Localization of tritiated 1-(2, 4-dichlorobenzyl)-1H-indazole-3-carboxylic acid ([3H] AF 1890) in rat testis using freeze-drying autoradiography.
Topics: Animals; Antispermatogenic Agents; Autoradiography; Blood-Testis Barrier; Freeze Drying; Histocytochemistry; Indazoles; Male; Pyrazoles; Rats; Rats, Inbred Strains; Seminiferous Tubules; Testis; Tissue Distribution; Tritium | 1982 |
Lonidamine: a new pharmacological approach to the study and control of spermatogenesis and tumors.
Topics: Animals; Antineoplastic Agents; Antispermatogenic Agents; Humans; Indazoles; Male; Pyrazoles | 1981 |
Preliminary results in some tumor systems with indazolecarboxylic acids.
Topics: Animals; Body Weight; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Germ Cells; Glycolysis; Indazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Time Factors | 1981 |
Effects of AF 1312 TS and lonidamine on mammalian testis. A morphological study.
Topics: Animals; Antispermatogenic Agents; Dogs; Dose-Response Relationship, Drug; Indazoles; Macaca fascicularis; Macaca mulatta; Male; Pyrazoles; Rabbits; Rats; Seminiferous Tubules; Sertoli Cells; Spermatids; Spermatozoa; Testis | 1981 |
Effects of AF 1312/TS and lonidamine on cultured sertoli cells.
Topics: Animals; Antispermatogenic Agents; Cells, Cultured; Cytoplasm; Energy Metabolism; Estradiol; Glycolysis; Indazoles; Male; Microscopy, Electron; Pyrazoles; Rats; Sertoli Cells | 1981 |
Changes of energy metabolism in the germ cells and Ehrlich ascites tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Energy Metabolism; Glycolysis; Indazoles; Kinetics; Male; Mitochondria; Mitochondria, Liver; Oxygen Consumption; Pyrazoles; Rats; Spermatozoa | 1981 |
Pharmacokinetics of lonidamine.
Topics: Administration, Oral; Animals; Antispermatogenic Agents; Half-Life; Indazoles; Injections, Intravenous; Kinetics; Macaca fascicularis; Macaca mulatta; Male; Pan troglodytes; Pyrazoles; Rabbits; Rats; Tissue Distribution | 1981 |
Localization of 3H-lonidamine in the rat testis.
Topics: Animals; Antispermatogenic Agents; Autoradiography; Cytoplasm; Freeze Drying; In Vitro Techniques; Indazoles; Male; Pyrazoles; Rats; Rats, Inbred Strains; Seminiferous Tubules; Sertoli Cells; Spermatids; Testis | 1981 |
Toxicological studies on 1-substituted-indazole-3-carboxylic acids.
Topics: Animals; Antispermatogenic Agents; Body Weight; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indazoles; Kidney; Lethal Dose 50; Macaca mulatta; Male; Mice; Organ Size; Pituitary Gland; Prostate; Pyrazoles; Rats; Semen; Testis | 1981 |
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Topics: Aerobiosis; Anaerobiosis; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Energy Metabolism; Glycolysis; Hexokinase; Indazoles; Lactates; Male; Mice; Mitochondria; Oxygen Consumption; Pyrazoles | 1981 |
Morphological and biochemical modifications of rat germ cell mitochondria induced by new antispermatogenic compounds: studies in vivo and in vitro.
Topics: Animals; Antispermatogenic Agents; Glycolysis; Indazoles; Male; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Pyrazoles; Rats; Testis | 1981 |
Mitochondria-bound hexokinase as target for therapy of malignant gliomas.
Topics: Adenosine Triphosphate; Adult; Aged; Animals; Female; Glioma; Hexokinase; Humans; Indazoles; Lactates; Male; Mice; Mice, Nude; Middle Aged; Mitochondria; Neoplasm Transplantation | 1995 |
Rat testicular testibumin is identical to sulfated glycoprotein-1 (SGP-1) whose mRNA expression in the testis is age- but not germ cell-dependent.
Topics: Aging; Amino Acid Sequence; Animals; Antispermatogenic Agents; Base Sequence; Chromatography, High Pressure Liquid; Cloning, Molecular; DNA, Complementary; Electrophoresis; Gene Expression Regulation; Glycoproteins; Indazoles; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saposins; Sertoli Cells; Spermatozoa; Testis | 1994 |
Relative cytotoxicities of adriamycin and epirubicin in combination with lonidamine against human bladder cancer cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Doxorubicin; Drug Resistance, Multiple; Epirubicin; Humans; Indazoles; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1995 |
Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyglucose; Glucose; Glycolysis; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Indazoles; Lactates; Magnetic Resonance Spectroscopy | 1995 |
Elevated doses of carmustine and mitomycin C, with lonidamine enhancement and autologous bone marrow transplantation in the treatment of advanced colorectal cancer: results from a pilot study.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Indazoles; Male; Middle Aged; Mitomycin; Pilot Projects; Rectal Neoplasms; Survival Analysis | 1994 |
In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Cell Cycle; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Indazoles; Mitomycin; Tumor Cells, Cultured | 1994 |
Intracellular localization of the antitumour drug adriamycin in living cultured cells: a confocal microscopy study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Fluorescence; Humans; Indazoles; Melanoma; Microscopy, Confocal; Tumor Cells, Cultured; Verapamil | 1994 |
Lonidamine-mediated respiratory changes in rat heart myocytes: a re-examination of the functional response of mitochondrial cytochrome c oxidase.
Topics: Animals; Cells, Cultured; Electron Transport Complex IV; Indazoles; Male; Mitochondria, Heart; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 1994 |
Enhancement of hyperthermic toxicity by lonidamine in the Dunning R3327G rat prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Chemotherapy, Adjuvant; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; Hot Temperature; Hyperthermia, Induced; Indazoles; Male; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Tumor Cells, Cultured | 1994 |
Modulation of antitumor alkylating agents by novobiocin, topotecan, and lonidamine.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Drug Synergism; Female; Fibrosarcoma; Humans; Indazoles; Male; Mice; Mice, Inbred C3H; Novobiocin; Topotecan; Tumor Cells, Cultured | 1993 |
Morphological changes in the hearts of CD1 mice following chronic treatment with doxorubicin and lonidamine.
Topics: Animals; Antineoplastic Agents; Doxorubicin; Female; Heart; Heart Septum; Heart Ventricles; Indazoles; Mice; Myocardium | 1993 |
Non-ionophoretic elevation of intracellular Ca2+ by Lonidamine.
Topics: Animals; Antineoplastic Agents; Antispermatogenic Agents; Binding Sites; Calcium; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Egtazic Acid; Fura-2; Humans; Indazoles; Intracellular Membranes; Liposomes; Rats; Tumor Cells, Cultured; Up-Regulation | 1993 |
Thermal behavior of a human glioma cell line and its response to combinations of hyperthermia and lonidamine.
Topics: Antineoplastic Agents; Combined Modality Therapy; Glioma; Hot Temperature; Humans; Hyperthermia, Induced; Indazoles; Tumor Cells, Cultured | 1993 |
Cisplatin plus epirubicin and etoposide followed by irradiation plus lonidamine in stage III nonsmall cell lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Indazoles; Lung Neoplasms; Male; Middle Aged | 1993 |
Efficacy of lonidamine combined with different DNA-damaging agents in the treatment of the MX-1 tumor xenograft.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; DNA Damage; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Indazoles; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured | 1996 |
Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Dogs; Indazoles; Injections, Intravenous; Kinetics; Liver; Male; Testis; Vomiting | 1996 |
An on-line semi-automated solid-phase extraction procedure for high-performance liquid chromatographic determination of lonidamine in serum.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Humans; Indazoles; Ovarian Neoplasms | 1995 |
Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carmustine; Cell Line; Doxorubicin; Drug Resistance; Female; Glioblastoma; Humans; Indazoles; Treatment Failure; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glucose; Hexokinase; Humans; Indazoles; Mitochondria; Tumor Cells, Cultured | 1996 |
Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Cricetulus; Energy Metabolism; Indazoles; Levamisole; NAD; Nucleotides; Photochemotherapy; Protoporphyrins | 1996 |
Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions.
Topics: Animals; Antispermatogenic Agents; Cell Membrane; Estrus; Female; Gene Expression Regulation, Developmental; Indazoles; Intercellular Junctions; Kidney; Male; Ovary; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Testis; Uterus | 1997 |
Comparison of action of the anti-neoplastic drug lonidamine on drug-sensitive and drug-resistant human breast cancer cells: 31P and 13C nuclear magnetic resonance studies.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon Isotopes; Deoxyglucose; Drug Resistance, Neoplasm; Female; Humans; Indazoles; Magnetic Resonance Spectroscopy; Phosphorus Isotopes; Tumor Cells, Cultured | 1997 |
Role of nuclear magnetic resonance spectroscopy (MRS) in cancer diagnosis and treatment: 31P, 23Na, and 1H MRS studies of three models of pancreatic cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma, Papillary; Animals; Antineoplastic Agents; Carcinogens; Cricetinae; Deoxyglucose; Humans; Indazoles; Magnetic Resonance Spectroscopy; Male; Mesocricetus; Neoplasm Transplantation; Pancreatic Neoplasms; Phosphorus; Protons; Rats; Rats, Sprague-Dawley; Sodium; Tumor Cells, Cultured | 1997 |
Saporin 6 and lonidamine in primary cell cultures from human breast carcinomas: a synergistic effect.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Cycle; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Immunotoxins; Indazoles; Middle Aged; N-Glycosyl Hydrolases; Phenotype; Plant Proteins; Receptors, Estrogen; Receptors, Progesterone; Ribosome Inactivating Proteins, Type 1; Saporins; Tumor Cells, Cultured | 1997 |
Modulation by lonidamine on the combined activity of cisplatin and epidoxorubicin in human breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cell Division; Cisplatin; Drug Administration Schedule; Drug Synergism; Epirubicin; Humans; Indazoles; Tumor Cells, Cultured | 1997 |
Objective response to epirubicin and lonidamine. A case of advanced thymoma previously treated with the ADOC scheme and unresponsive to paclitaxel plus cyclophosphamide.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Epirubicin; Female; Humans; Indazoles; Middle Aged; Paclitaxel; Remission Induction; Salvage Therapy; Thymoma; Thymus Neoplasms; Vincristine | 1997 |
Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring.
Topics: Age Factors; Animals; Antispermatogenic Agents; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Epithelium; Gene Expression Regulation, Developmental; Indazoles; Leydig Cells; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seminiferous Tubules; Sertoli Cells; Testis | 1997 |
The antineoplastic drug lonidamine interferes with the acidification mechanism of cell organelles.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Enzyme Inhibitors; Hydrogen-Ion Concentration; Indazoles; Lysosomes; Nigericin; Oligomycins; Organelles; Rats; Thymus Gland | 1997 |
Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid].
Topics: Animals; Female; Indazoles; Mice; Molecular Structure; NADP; Radiation-Sensitizing Agents; Tryptophan; Tumor Cells, Cultured; Ultraviolet Rays | 1997 |
Stimulation of the apoptotic response as a basis for the therapeutic synergism of lonidamine and cisplatin in combination in human tumour xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; DNA Damage; Drug Synergism; Female; Humans; Indazoles; Mice; Neoplasm Transplantation; Proto-Oncogene Proteins c-bcl-2; Transplantation, Heterologous | 1998 |
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Gliosarcoma; Hydrogen-Ion Concentration; Indazoles; Injections, Subcutaneous; Intracellular Fluid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Muscle Neoplasms; Neoplasm Transplantation; Phosphorus Radioisotopes; Rats; Rats, Inbred F344; Thigh | 1998 |
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Diazepam; Drug Synergism; Flow Cytometry; Fluorescence; Glioblastoma; Humans; Indazoles; Mice; Mice, Nude; Mitochondria; Thymidine; Treatment Outcome; Tumor Cells, Cultured | 1998 |
Lonidamine as a modulator of taxol activity in human ovarian cancer cells: effects on cell cycle and induction of apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Cycle; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mitotic Index; Ovarian Neoplasms; Paclitaxel; Poly(ADP-ribose) Polymerases; Protamine Kinase; Tubulin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism.
Topics: Adenine Nucleotides; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cell Respiration; Doxorubicin; Energy Metabolism; Female; Glycolysis; Hexokinase; Indazoles; Male; Mice; Mice, Inbred DBA; Mitochondria | 1998 |
Modulation of cytotoxic drug activity by mitotane and lonidamine in human adrenocortical carcinoma cells.
Topics: Adrenal Cortex Neoplasms; Antineoplastic Agents; Drug Synergism; Humans; Indazoles; Mitotane; Tumor Cells, Cultured | 1999 |
Interactions between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents; beta-Cyclodextrins; Calorimetry, Differential Scanning; Cyclodextrins; Drug Interactions; Indazoles; Solubility; Water; X-Ray Diffraction | 1998 |
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Cell-Free System; Cysteine Proteinase Inhibitors; Humans; Indazoles; Ion Channels; Isoquinolines; Mitochondria; Permeability; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Subcellular Fractions; U937 Cells | 1999 |
bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant MCF7 cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Doxorubicin; Drug Resistance, Neoplasm; Energy Metabolism; Humans; Indazoles; Mitochondria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection; Tumor Cells, Cultured | 1999 |
1H-MRS lipid signal modulation and morphological and ultrastructural changes related to tumor cell proliferation.
Topics: Antineoplastic Agents; Cell Cycle; Freeze Fracturing; HeLa Cells; Humans; Indazoles; Lipid Metabolism; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning | 1999 |
Sertoli cell prostaglandin D2 synthetase is a multifunctional molecule: its expression and regulation.
Topics: Aging; Animals; Animals, Newborn; Antispermatogenic Agents; Cell Membrane; Cells, Cultured; Cytosol; Dihydrotestosterone; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glycerol; Indazoles; Intramolecular Oxidoreductases; Kinetics; Lipocalins; Male; Progesterone; Rats; Rats, Sprague-Dawley; Retinaldehyde; RNA, Messenger; Sertoli Cells; Testis; Testosterone; Tretinoin | 2000 |
Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence of lonidamine.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Carbon Dioxide; Cell Division; Citrate (si)-Synthase; Colonic Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Energy Metabolism; Glucose; Hexokinase; Humans; Indazoles; Inhibitory Concentration 50; Isocitrate Dehydrogenase; Kinetics; Lactic Acid; Tumor Cells, Cultured | 2000 |
Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis.
Topics: Animals; Benzyl Compounds; Bicarbonates; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epididymis; Epithelial Cells; Indazoles; Male; Rats; Rats, Sprague-Dawley | 2000 |
Noninvasive real-time monitoring of intracellular cancer cell metabolism and response to lonidamine treatment using diffusion weighted proton magnetic resonance spectroscopy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Diffusion; Dose-Response Relationship, Drug; Humans; Indazoles; Ischemia; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Monitoring, Physiologic; Protons; Signal Processing, Computer-Assisted; Tumor Cells, Cultured | 2000 |
Correspondence re: M. Fanciulli et al., Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence fo lonidamine. Clin. Cancer Res., 6: 1590-1597, 2000.
Topics: Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Glycolysis; Hexokinase; Humans; Indazoles; Lactic Acid; Tumor Cells, Cultured | 2000 |
Testin induction: the role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat sertoli cells.
Topics: Actin Cytoskeleton; Animals; Antispermatogenic Agents; Blotting, Northern; Bucladesine; Cells, Cultured; Coculture Techniques; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Developmental; Germ Cells; Indazoles; Male; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Signal Transduction; Teratogens; Tight Junctions | 2000 |
Characterization of Lonidamine and AF2785 blockade of the cyclic AMP-activated chloride current in rat epididymal cells.
Topics: Animals; Antispermatogenic Agents; Benzyl Compounds; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Epididymis; Epithelial Cells; Indazoles; Ion Channel Gating; Ion Transport; Male; Molecular Structure; ortho-Aminobenzoates; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Second Messenger Systems | 2000 |
Analysis of lonidamine in rat serum and testis by high performance liquid chromatography.
Topics: Animals; Antispermatogenic Agents; Calibration; Chromatography, High Pressure Liquid; Indazoles; Male; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Testis | 2001 |
Changes in cell volume and internal sodium concentration in HeLa cells during exponential growth and following lonidamine treatment.
Topics: Antineoplastic Agents; Cell Division; Cell Size; G1 Phase; HeLa Cells; Humans; Indazoles; Magnetic Resonance Spectroscopy; Sodium; Sodium Isotopes | 2001 |
Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Cell Differentiation; Cell-Free System; Drug Resistance; Etoposide; Humans; Indazoles; Leukemia; Mitochondria; Oxides; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; U937 Cells | 2001 |
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.
Topics: Antineoplastic Agents; Apoptosis; Arsenites; Cell Membrane Permeability; Cytomegalovirus; HeLa Cells; Humans; Immediate-Early Proteins; Indazoles; Intracellular Membranes; Jurkat Cells; Mitochondria; Mitochondrial ADP, ATP Translocases; Retinoids; Viral Proteins | 2001 |
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Base Sequence; Blotting, Western; Caspase 3; Caspases; Colonic Neoplasms; DNA Primers; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Indazoles; Models, Biological; Organoplatinum Compounds; Oxaliplatin; Oxides; Proto-Oncogene Proteins c-bcl-2 | 2002 |
Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Humans; Indazoles; Mitochondria | 2002 |
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Membrane Potentials; Mutation; Transfection | 2002 |
Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl(-) channels in rat epididymal epithelial cells.
Topics: Animals; Benzyl Compounds; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epididymis; Epithelial Cells; Indazoles; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2002 |
Lonidamine solid dispersions: in vitro and in vivo evaluation.
Topics: Animals; Area Under Curve; Biological Availability; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cyclodextrins; Indazoles; Male; Polyethylene Glycols; Rats; Rats, Wistar; X-Ray Diffraction | 2002 |
Hepatocytes transgenic for the full hepatitis C virus open reading frame are resistant to fas-induced cell death.
Topics: Animals; Antineoplastic Agents; Cell Death; Cells, Cultured; fas Receptor; Hepacivirus; Hepatocytes; Indazoles; Mice; Mice, Transgenic; Mitochondria; Open Reading Frames; Recombinant Proteins | 2002 |
Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis.
Topics: Absorption; Algorithms; Animals; Aquaporins; Cell Membrane Permeability; Chloride Channels; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Epididymis; In Vitro Techniques; Indazoles; Male; Microinjections; Oocytes; Osmosis; Phloretin; Rats; Reverse Transcriptase Polymerase Chain Reaction; Xenopus laevis | 2003 |
Effect of lonidamine on alpha2-macroglobulin, hemopexin and alpha1-antitrypsin in the rat testis and epididymis.
Topics: Acute-Phase Proteins; alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Electrophoresis, Polyacrylamide Gel; Epididymis; Hemopexin; Indazoles; Male; Rats; Rats, Sprague-Dawley; Testis | 2001 |
Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antioxidants; Antipyrine; Atractyloside; Blood Pressure; Cytochromes c; DNA Fragmentation; Edaravone; Enzyme Inhibitors; Heart Rate; Indazoles; Male; Mitochondrial Swelling; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Up-Regulation | 2003 |
Ultralow doses of various drugs in chemotherapy of experimental tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Indazoles; Leukemia P388; Lung Neoplasms; Melanoma; Mice; Mitomycin; Neoplasm Metastasis; Neoplasms, Experimental; Triazoles; Xenograft Model Antitumor Assays | 2003 |
Potentiation of antiproliferative drug activity by lonidamine in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Drug Interactions; Humans; Indazoles; Liver Neoplasms; Paclitaxel; Tumor Cells, Cultured | 2003 |
Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries.
Topics: Animals; Bongkrekic Acid; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Calcium-Binding Proteins; Calcium-Transporting ATPases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Arteries; Clonazepam; Cyclosporine; Diltiazem; Female; Hydrogen Peroxide; Indazoles; Ion Channels; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria, Muscle; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Smooth Muscle; Oligomycins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rhodamines; Rotenone; Ruthenium Compounds; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Thapsigargin; Thiazepines | 2004 |
Apoptosis of human melanoma cells by a combination of lonidamine and radiation.
Topics: Antineoplastic Agents; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cell Line, Tumor; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Melanoma; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53; X-Rays | 2004 |
Lonidamine transiently affects spermatogenesis in pubertal CD1 mice.
Topics: Animals; Antispermatogenic Agents; Chromatin; DNA; Flow Cytometry; Indazoles; Male; Mice; Organ Size; Sexual Maturation; Sperm Count; Sperm Head; Spermatogenesis; Spermatozoa; Testis | 2005 |
Long-term effects of lonidamine on mouse testes.
Topics: Animals; Antispermatogenic Agents; DNA; Flow Cytometry; Indazoles; Male; Mice; Organ Size; Seminiferous Epithelium; Seminiferous Tubules; Sperm Count; Spermatogenesis; Testis; Time Factors | 2005 |
Chemosensitization by knockdown of adenine nucleotide translocase-2.
Topics: Adenine Nucleotide Translocator 1; Adenine Nucleotide Translocator 2; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Silencing; HeLa Cells; Humans; Indazoles; Mitochondrial Membranes; Permeability; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering | 2006 |
Lonidamine affects testicular steroid hormones in immature mice.
Topics: Age Factors; Androstenedione; Animals; Antispermatogenic Agents; Enzyme-Linked Immunosorbent Assay; Estradiol; Hydroxyprogesterones; Indazoles; Intubation, Gastrointestinal; Male; Mice; Microscopy, Polarization; Organ Size; Seminiferous Tubules; Sertoli Cells; Sperm Count; Spermatogenesis; Spermatozoa; Testicular Hormones; Testis; Testosterone; Time Factors | 2007 |
Evaluation of contraceptive activity of methanol extract of Dendrophthoe falcata stem in male albino rats.
Topics: Animals; Contraceptive Agents, Male; Dose-Response Relationship, Drug; Genitalia, Male; Indazoles; Loranthaceae; Male; Methanol; Organ Size; Plant Extracts; Plants, Medicinal; Rats; Solvents; Spermatozoa; Testosterone | 2007 |
The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1.
Topics: Animals; Culture Media; Enzyme Inhibitors; Gene Silencing; Hexokinase; Indazoles; Recombinant Proteins; RNA Interference; Transfection; Trypanocidal Agents; Trypanosoma brucei brucei | 2008 |
Glycosyl and polyalcoholic prodrugs of lonidamine.
Topics: Absorption; Administration, Oral; Alcohols; Animals; Antineoplastic Agents; Cell Line, Tumor; Glycosides; Humans; Hydrolysis; Indazoles; Models, Chemical; Prodrugs; Rats; Solubility; Structure-Activity Relationship; Water | 2008 |
[Treatment and post-treatment with lonidamine in human colon carcinoma HT-29 cell line].
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Hexokinase; HT29 Cells; Humans; Indazoles; Mitochondria | 2008 |
Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine.
Topics: Acridine Orange; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Gamma Rays; Humans; Indazoles; Radiation-Sensitizing Agents; Radiotherapy; Temozolomide | 2008 |
Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells.
Topics: Acridine Orange; Betulinic Acid; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Death; Cell Line, Tumor; Cell Survival; Cyclosporine; Cytostatic Agents; Dacarbazine; Drug Resistance, Neoplasm; ErbB Receptors; Glioma; Humans; Indazoles; Membrane Potential, Mitochondrial; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Pentacyclic Triterpenes; Polymerase Chain Reaction; Retinoids; Temozolomide; Triterpenes | 2009 |
Development of a yeast bio-assay to screen anti-mitochondrial drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Biological Assay; Drug Evaluation, Preclinical; Eremothecium; Indazoles; Mitochondria; Oxygen; Oxylipins | 2009 |
Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxyglucose; Glioma; Humans; Indazoles; Micronucleus Tests; Radiation-Sensitizing Agents | 2009 |
The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells.
Topics: Adenine Nucleotide Translocator 3; Antineoplastic Agents; Apoptosis; Caspase 9; Cell Proliferation; Cell Shape; Cytoprotection; HeLa Cells; Humans; Hydrogen Peroxide; Indazoles; Isoenzymes; Mitochondria; Mitochondrial ADP, ATP Translocases; Oxidative Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Superoxides | 2010 |
Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Survival; Curcumin; Electrophoretic Mobility Shift Assay; Flow Cytometry; Glutathione; HL-60 Cells; Humans; Indazoles; Membrane Potentials; Mitochondria; Oxidants; Oxides; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; U937 Cells | 2010 |
Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Resistance, Multiple; ErbB Receptors; Female; Humans; Indazoles; Nanoparticles; Ovarian Neoplasms; Paclitaxel; Polymers | 2011 |
Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chromatography, High Pressure Liquid; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Female; Indazoles; Mice; Mice, Nude; Nanoparticles; Nanotechnology; Paclitaxel | 2011 |
Monoamine carboxylate transporters are involved in BI-1-associated cancer metastasis in HT1080 colon fibrosarcoma cells.
Topics: Apoptosis Regulatory Proteins; Cell Death; Cell Line, Tumor; Colonic Neoplasms; Extracellular Space; Fibrosarcoma; Gene Expression; Homeostasis; Humans; Hydrogen-Ion Concentration; Indazoles; Membrane Proteins; Neoplasm Metastasis; Sodium-Hydrogen Exchangers; Vesicular Monoamine Transport Proteins | 2011 |
Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Leukemia; Membrane Potential, Mitochondrial; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Mice; Mice, Nude; Microscopy, Electron, Scanning; Nanoparticles; Neoplasms; Paclitaxel; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.
Topics: Adenosine Triphosphate; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Respiration; Enzyme Activation; Hep G2 Cells; Humans; Indazoles; Longevity; Mitochondria; Mitogen-Activated Protein Kinases; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Stress, Physiological | 2011 |
(31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Drug Synergism; Energy Metabolism; Hydrogen-Ion Concentration; Indazoles; Magnetic Resonance Spectroscopy; Melanoma; Melphalan; Mice; Phosphorus Radioisotopes; Protons; Treatment Outcome | 2013 |
Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics.
Topics: 2,4-Dinitrophenol; Adipogenesis; alpha-Tocopherol; Analysis of Variance; Bioengineering; Curcumin; Drug Delivery Systems; Humans; Indazoles; Mitochondrial Diseases; Nanoparticles; Polyethylene Glycols; Polyglactin 910; Polymers | 2012 |
Development of targeting lonidamine liposomes that circumvent drug-resistant cancer by acting on mitochondrial signaling pathways.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; bcl-2-Associated X Protein; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Delivery Systems; Drug Resistance, Neoplasm; Enzyme Activation; Epirubicin; Female; Humans; Indazoles; Liposomes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Xenograft Model Antitumor Assays | 2013 |
Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxyglucose; Drug Administration Schedule; Glycolysis; Hexokinase; Humans; Indazoles; Mammary Glands, Human; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Tumor Stem Cell Assay | 2013 |
The 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migration.
Topics: Acinar Cells; Apoptosis; Benzodiazepinones; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Size; Disease Progression; Humans; Indazoles; Isoquinolines; Ligands; Mammary Glands, Human; Neoplasm Invasiveness; Receptors, GABA | 2013 |
Differential sensitivities to lactate transport inhibitors of breast cancer cell lines.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Female; Humans; Immunohistochemistry; Indazoles; Inhibitory Concentration 50; Monocarboxylic Acid Transporters; Quercetin; RNA, Small Interfering; Transfection | 2014 |
Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH.
Topics: Cell Line, Tumor; Cell Survival; Heat-Shock Proteins; Hot Temperature; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Indazoles; Melanoma; Molecular Chaperones; Monocarboxylic Acid Transporters; Radiation-Sensitizing Agents | 2014 |
The energy blockers 3-bromopyruvate and lonidamine: effects on bioenergetics of brain mitochondria.
Topics: Animals; Antineoplastic Agents; Brain; Energy Metabolism; Enzyme Inhibitors; Indazoles; Mitochondria; Oxygen Consumption; Pyruvates; Rats | 2014 |
Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin.
Topics: Acids; Adenosine Triphosphate; Animals; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Synergism; Energy Metabolism; Female; Humans; Hydrogen-Ion Concentration; Indazoles; Intracellular Space; Magnetic Resonance Spectroscopy; Male; Mice, Nude; Monocarboxylic Acid Transporters; Ovarian Neoplasms; Prostatic Neoplasms; Symporters; Xenograft Model Antitumor Assays | 2015 |
Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Deoxyglucose; Epoxy Compounds; Glycolysis; Humans; Indazoles; Leukemia, Myeloid, Acute; Oxidative Stress; Oxides; Protein Kinases | 2014 |
Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan.
Topics: Acids; Animals; Cell Line, Tumor; Cell Proliferation; Energy Metabolism; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Indazoles; Intracellular Space; Magnetic Resonance Spectroscopy; Male; Melanoma; Melphalan; Mice, Nude; Organ Specificity; Xenograft Model Antitumor Assays | 2015 |
Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Contrast Media; Humans; Hydrogen-Ion Concentration; Image Interpretation, Computer-Assisted; Indazoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Molecular Imaging; Reproducibility of Results; Sensitivity and Specificity; Tumor Cells, Cultured | 2015 |
Limitations of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay when compared to three commonly used cell enumeration assays.
Topics: Artifacts; Biological Assay; Cell Count; Cell Line, Tumor; Cell Survival; Deoxyglucose; Glycolysis; Humans; Indazoles; Neutral Red; Observer Variation; Oxazines; Oxidation-Reduction; Pyruvates; Reproducibility of Results; Rhodamines; Sensitivity and Specificity; Staining and Labeling; Tetrazolium Salts; Thiazoles; Xanthenes | 2015 |
Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Diffusion; HeLa Cells; Humans; Indazoles; Mitochondria; Mitochondrial Proteins; Nanocapsules; RNA, Small Interfering; Signal Transduction; Treatment Outcome | 2015 |
[Lonidamine induces apoptosis via endoplasmic reticulum stress response and down-regulating cIAP expression in human breast carcinoma MCF-7 cells].
Topics: Apoptosis; Breast Neoplasms; Caspase 8; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Indazoles; Inhibitor of Apoptosis Proteins; MCF-7 Cells; Ubiquitin-Protein Ligases; Up-Regulation | 2015 |
Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.
Topics: Animals; Apoptosis; Cell Survival; Diazooxonorleucine; Drug Synergism; Fatty Acid Synthases; Fatty Acids; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glycolysis; Hexokinase; Humans; Indazoles; Lactones; Metabolic Networks and Pathways; Mice; Neoplasms; Orlistat | 2015 |
The energy blockers bromopyruvate and lonidamine lead GL15 glioblastoma cells to death by different p53-dependent routes.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Energy Metabolism; Enzyme Inhibitors; Glioblastoma; Humans; Indazoles; Mitochondria; Pyruvates; Tumor Suppressor Protein p53 | 2015 |
Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hyaluronic Acid; Indazoles; Lipids; Liposomes; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Neoplasms; Paclitaxel; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Vitamin E | 2015 |
Coassemblies of the Anionic Polypeptide γ-PGA and Cationic β-Sheet Peptides for Drug Delivery to Mitochondria.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Compounding; Drug Liberation; Humans; Hydrophobic and Hydrophilic Interactions; Indazoles; Kinetics; Mitochondria; Nanoparticles; Osteoblasts; Ovalbumin; Particle Size; Peptides; Polyglutamic Acid; Static Electricity | 2015 |
Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Citric Acid Cycle; Diacetyl; Electron Transport Complex II; Fumarates; Glutamine; Glutathione; Humans; Indazoles; Malates; Melanoma; Metabolic Flux Analysis; Mitochondria; Models, Biological; NADP; Naphthalenes; Oxidation-Reduction; Pentose Phosphate Pathway; Reactive Oxygen Species; Succinic Acid | 2016 |
The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Membrane; Indazoles; Ion Transport; Lactic Acid; Male; Membrane Transport Proteins; Mitochondrial Proteins; Monocarboxylic Acid Transporters; Pyruvic Acid; Rats; Rats, Wistar; Solute Carrier Proteins; Symporters | 2016 |
In vivo synergistic antitumor effect and safety of siRNA and lonidamine dual-loaded hierarchical targeted nanoparticles.
Topics: Animals; Antineoplastic Agents; Drug Carriers; Drug Delivery Systems; In Situ Nick-End Labeling; Indazoles; Male; Mice; Mice, Inbred ICR; Nanoparticles; Polymers; RNA, Small Interfering; Sarcoma; Xenograft Model Antitumor Assays | 2016 |
Role of Vitamin C in Cardioprotection of Ischemia/Reperfusion Injury by Activation of Mitochondrial KATP Channel.
Topics: Animals; Ascorbic Acid; Cardiotonic Agents; Decanoic Acids; Hydroxy Acids; Indazoles; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug Synergism; Humans; Indazoles; Male; Mechlorethamine; Melanoma; Melphalan; Mice; Mice, Nude; Mice, SCID; Xenograft Model Antitumor Assays | 2016 |
Targeting hexokinase II as a possible therapy for cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Cell Division; Cell Line, Tumor; Cholangiocarcinoma; Cricetinae; Disease Progression; Enzyme Inhibitors; Hexokinase; Immunohistochemistry; Indazoles; Opisthorchis | 2017 |
Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with α-catenin at the blood-testis barrier.
Topics: alpha Catenin; Animals; Antispermatogenic Agents; Blood-Testis Barrier; Cytoskeleton; gamma Catenin; Indazoles; Male; Phosphorylation; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Testis | 2017 |
Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Synergism; Heterografts; Humans; Indazoles; Melanoma; Mice; Mice, Nude; Temozolomide; Transplantation, Heterologous | 2017 |
Mitochondria-targeting near-infrared light-triggered thermosensitive liposomes for localized photothermal and photodynamic ablation of tumors combined with chemotherapy.
Topics: Animals; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Indazoles; Infrared Rays; Liposomes; Mice; Mice, Inbred BALB C; Mitochondria; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Xenograft Model Antitumor Assays | 2017 |
Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance.
Topics: Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Resistance; Humans; Indazoles; Nanoparticles | 2017 |
Negatively charged polypeptide-peptide nanoparticles showing efficient drug delivery to the mitochondria.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Humans; Hydrophobic and Hydrophilic Interactions; Indazoles; Kinetics; Mitochondria; Nanoparticles; Osteoblasts; Peptides; Polyglutamic Acid; Static Electricity | 2018 |
Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cisplatin; Drug Synergism; Humans; Indazoles; Mitochondria; Prodrugs; Reactive Oxygen Species; S Phase | 2018 |
Optical Redox Imaging of Lonidamine Treatment Response of Melanoma Cells and Xenografts.
Topics: Animals; Cell Line, Tumor; Electron Transport; Heterografts; Humans; Indazoles; Melanoma; Mice, Nude; Mitochondria; Mitochondrial Uncoupling Proteins; Optical Imaging; Oxidation-Reduction | 2019 |
Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Indazoles; Lung Neoplasms; Radiation Tolerance; X-Rays | 2018 |
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
Topics: Adult; Aged; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Female; Hexokinase; Humans; Indazoles; Inflammation Mediators; Macrophages; Male; Mice, Inbred DBA; Middle Aged; RNA Interference; Synovial Membrane; Synoviocytes; THP-1 Cells | 2019 |
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Topics: Animals; Antineoplastic Agents; Autophagy; Brain Neoplasms; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Delivery Systems; Electron Transport Complex I; Electron Transport Complex II; Female; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Mitochondria; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2019 |
Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Indazoles; Mice, Inbred BALB C; Mitochondria; Nanoparticles; Peptides; Xenograft Model Antitumor Assays | 2019 |
Doxorubicin combined with betulinic acid or lonidamine in RGD ligand-targeted pH-sensitive micellar system for ovarian cancer treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arginine; Aspartic Acid; Betulinic Acid; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Compounding; Drug Liberation; Female; Glycine; Humans; Hydrogen-Ion Concentration; Indazoles; Leukocyte Count; Ligands; Mice; Micelles; Oligopeptides; Ovarian Neoplasms; Pentacyclic Triterpenes; Tissue Distribution; Triterpenes; Xenograft Model Antitumor Assays | 2019 |
Multi-responsive albumin-lonidamine conjugated hybridized gold nanoparticle as a combined photothermal-chemotherapy for synergistic tumor ablation.
Topics: Albumins; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endocytosis; Gold; Humans; Indazoles; Metal Nanoparticles; Mice, Inbred BALB C; Mice, Nude; Photothermal Therapy; Reactive Oxygen Species; Tissue Distribution; Xenograft Model Antitumor Assays | 2020 |
An enzyme-assisted self-delivery system of lonidamine-peptide conjugates for selectively killing cancer cells.
Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Hydrogels; Indazoles; Mice; Neoplasms; Peptides; Transplantation, Heterologous | 2019 |
In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis.
Topics: 6-Aminonicotinamide; Animals; Anticestodal Agents; Echinococcosis; Echinococcus granulosus; Echinococcus multilocularis; Indazoles; Larva | 2020 |
Mouse Model for Efficient Simultaneous Targeting of Glycolysis, Glutaminolysis, and De Novo Synthesis of Fatty Acids in Colon Cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Diazooxonorleucine; Drug Screening Assays, Antitumor; Fatty Acid Synthase, Type I; Fatty Acids; Female; Glutaminase; Glutamine; Glycolysis; Hexokinase; Indazoles; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Orlistat; Smegmamorpha | 2021 |
Antifungal effects and potential mechanisms of lonidamine in combination with fluconazole against
Topics: Antifungal Agents; Biofilms; Candida albicans; Drug Resistance, Fungal; Drug Synergism; Drug Therapy, Combination; Fluconazole; Humans; Indazoles; Reactive Oxygen Species; Time Factors; Virulence Factors | 2021 |
Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid-polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model.
Topics: Animals; Apoptosis; Disease Models, Animal; Drug Compounding; Enzyme Inhibitors; Hexokinase; Indazoles; Lipids; Liver; Male; Nanomedicine; Nanoparticles; Polymers; Prostate; Prostatic Hyperplasia; Rats | 2020 |
Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.
Topics: Apoptosis; Breast Neoplasms; Down-Regulation; Humans; Indazoles; Matrix Metalloproteinase 2; MCF-7 Cells; Quercetin; RNA, Messenger | 2020 |
Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; Female; Hexokinase; Humans; Indazoles; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Transgenic; Nigericin; Positron-Emission Tomography; Thiazolidines; Thiones; Up-Regulation | 2021 |
Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Daunorubicin; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glycolysis; Growth Hormone; Humans; Indazoles; Indomethacin; Insulin; Metabolic Networks and Pathways; Metabolism; Mice; Mitoxantrone; Orlistat; Oxidative Phosphorylation; Vincristine | 2021 |
Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Delivery Systems; Humans; Indazoles; Indoles; Kidney Neoplasms; Mice; Mitochondria; Nanoparticles; Photothermal Therapy; Polymers; Silicon Dioxide; Xenograft Model Antitumor Assays | 2021 |
Glucose and Triphenylphosphonium Co-Modified Redox-Sensitive Liposomes to Synergistically Treat Glioma with Doxorubicin and Lonidamine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Doxorubicin; Drug Carriers; Drug Delivery Systems; Glioma; Glucose; Humans; Indazoles; Liposomes; Organophosphorus Compounds; Oxidation-Reduction; Tumor Cells, Cultured | 2021 |
Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Membrane; Cell Proliferation; Drug Carriers; Drug Liberation; Female; Ferrocyanides; Hep G2 Cells; Humans; Indazoles; Infrared Rays; Mice, Nude; Mitochondria; Nanocomposites; Nanoparticles; Neoplasms; Photothermal Therapy | 2021 |
Ru(III) Complexes with Lonidamine-Modified Ligands.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Indazoles; Ligands; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Oxidation-Reduction; Ruthenium; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase | 2021 |
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles.
Topics: A549 Cells; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Drug Carriers; Drug Combinations; Extracellular Vesicles; Female; Humans; Indazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Particle Size; Random Allocation; Xenograft Model Antitumor Assays | 2022 |
Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma.
Topics: Animals; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Glioma; Hydroxybenzoates; Indazoles; Liposomes; Mice | 2022 |
The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells.
Topics: Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Survival; Deoxyglucose; Glucose; Glycolysis; Head and Neck Neoplasms; Humans; Indazoles; Pyrimidinones; Tongue; Tongue Neoplasms; Wnt Signaling Pathway | 2022 |
Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects.
Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Copper; Crystallography, X-Ray; Humans; Indazoles; Ligands; Molecular Structure | 2022 |
pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma.
Topics: Cell Line, Tumor; Doxorubicin; Glioma; Glucose; Humans; Hydrogen-Ion Concentration; Indazoles; Ligands; Liposomes; Oxidation-Reduction; Prodrugs | 2022 |
Carrier-free prodrug nanoparticles based on lonidamine and cisplatin for synergistic treatment of breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Female; Glutathione; Humans; Indazoles; Nanoparticles; Prodrugs | 2022 |
Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
Topics: Antineoplastic Agents; Cell Line, Tumor; Indazoles; Ligands; Prodrugs | 2022 |
The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease.
Topics: Actins; Animals; Carboxylic Acids; Cell Proliferation; Cells, Cultured; Colforsin; Cyclin-Dependent Kinase 4; Cystic Fibrosis Transmembrane Conductance Regulator; Cysts; EGF Family of Proteins; Heat-Shock Proteins; Humans; Indazoles; Kidney; Mice; Polycystic Kidney Diseases; Polycystic Kidney, Autosomal Dominant; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface | 2022 |
Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
Topics: Animals; Antineoplastic Agents; Domperidone; Drug Screening Assays, Antitumor; Epithelial Cells; Indazoles; Mammary Glands, Animal; Mice; Neoplasms | 2022 |