Page last updated: 2024-08-21

indazoles and ketoconazole

indazoles has been researched along with ketoconazole in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brand, L; Harvey, BH; Oosthuizen, F; Stein, DJ; Wegener, G1
Garrett, M; Hee, B; Klamerus, KJ; Mount, J; Pithavala, YK; Rahavendran, SV; Sarapa, N; Selaru, P; Tong, W1
Botbyl, J; Edenfield, JW; Gibbon, DG; Gregory, C; Lindquist, D; Martin, JC; Stein, MN; Stephenson, JJ; Suttle, AB; Tada, H; Tan, AR1
Houk, BE; Pithavala, YK; Ruiz-Garcia, A; Sarapa, N; Toh, M; Tortorici, MA1
Liu, XJ; Lu, H; Mo, YS; Shi, BK; Sun, JX; Wang, SR; Yang, XS1
Badolo, L; Jede, C; Koziolek, M; Kubas, H; Lecomte, M; Wagner, C; Weber, C; Weigandt, M; Weitschies, W1

Trials

3 trial(s) available for indazoles and ketoconazole

ArticleYear
Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers.
    Investigational new drugs, 2012, Volume: 30, Issue:1

    Topics: Administration, Oral; Adult; Angiogenesis Inhibitors; Area Under Curve; Axitinib; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Imidazoles; Indazoles; Ketoconazole; Male; Middle Aged; Phenotype; Single-Blind Method

2012
Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors.
    Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Esomeprazole; Female; Humans; Indazoles; Ketoconazole; Male; Middle Aged; Neoplasms; Proton Pump Inhibitors; Pyrimidines; Sulfonamides

2013
Effect of axitinib on the QT interval in healthy volunteers.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:3

    Topics: Adult; Axitinib; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Electrocardiography; Female; Heart Rate; Humans; Imidazoles; Indazoles; Ketoconazole; Male; Models, Biological; Protein Kinase Inhibitors; Single-Blind Method

2015

Other Studies

3 other study(ies) available for indazoles and ketoconazole

ArticleYear
Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus.
    Psychopharmacology, 2004, Volume: 175, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Corticosterone; Electrochemistry; Enzyme Inhibitors; gamma-Aminobutyric Acid; Guanidines; Hippocampus; Indazoles; Ketoconazole; Kinetics; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Stress Disorders, Post-Traumatic; Stress, Psychological

2004
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
    European journal of drug metabolism and pharmacokinetics, 2016, Volume: 41, Issue:4

    Topics: Amino Acids; Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Humans; Indazoles; Ketoconazole; Molecular Docking Simulation; Ovarian Neoplasms; Oxidation-Reduction; Pyrimidines; Sulfonamides

2016
Improved Prediction of in Vivo Supersaturation and Precipitation of Poorly Soluble Weakly Basic Drugs Using a Biorelevant Bicarbonate Buffer in a Gastrointestinal Transfer Model.
    Molecular pharmaceutics, 2019, 09-03, Volume: 16, Issue:9

    Topics: Administration, Oral; Animals; Bicarbonates; Buffers; Chemical Precipitation; Drug Delivery Systems; Drug Liberation; Female; Gastrointestinal Absorption; Gastrointestinal Tract; Hydrogen-Ion Concentration; Indazoles; Ketoconazole; Lapatinib; Methylcellulose; Models, Biological; Phosphates; Pyrimidines; Rats; Rats, Wistar; Solubility; Sulfonamides

2019