indazoles has been researched along with ici 198615 in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (20.59) | 18.7374 |
| 1990's | 52 (76.47) | 18.2507 |
| 2000's | 2 (2.94) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernstein, PR; Brown, FJ; Cronk, LA; Krell, RD; Maduskuie, TP; Matassa, VG; Shapiro, HS; Snyder, DW; Vacek, EP; Yee, YK | 1 |
| Adler, L; Hageman, JR; Holtzman, RB; Kertesz, NJ | 1 |
| Falcone, RC; Krell, RD | 1 |
| Giovanazzi, S; Mezzetti, M; Nicosia, S; Rovati, GE | 1 |
| Hamada, M; Hasegawa, S; Hirata, F; Kameyama, M; Nomura, A; Ohse, H; Uchida, Y | 1 |
| Dan-Cohen, H; Nadler, JL; Naor, Z; Natarajan, RD; Schwartzman, ML; Sofer, Y | 1 |
| Berild, D; Bouchelouche, PN | 1 |
| Ford-Hutchinson, AW; Frey, EA; Metters, KM | 1 |
| Aharony, D; Falcone, RC; Orzechowski, RF | 2 |
| Cheng, JB; Shirley, JT | 1 |
| Aharony, D; Falcone, RC; Moore, WC; Orzechowski, RF; Scott, AL; Siegl, PK | 1 |
| Dahlén, SE; Hedqvist, P; Kumlin, M; Palmertz, U; Raud, J | 1 |
| Björck, T; Dahlén, B; Dahlén, SE; Harada, Y; Hedqvist, P; Johansson, G; Rodriguez, L; Zetterström, O | 1 |
| Campbell, HF; Carnathan, GW; Dankulich, WP; Galemmo, RA; Huang, FC; Johnson, WH; Learn, KS; Morrissette, MM; Poli, GB; VanInwegen, RG | 1 |
| McLeod, JD; Piper, PJ | 1 |
| Hsueh, W; Zhang, C | 1 |
| Mong, S; Sarau, HM | 1 |
| Aharony, D; Fedyna, JS; Krell, RD; Redkar-Brown, D; Snyder, DW | 1 |
| Abram, TS; Cuthbert, NJ; Gardiner, PJ | 1 |
| Aharony, D | 1 |
| Nelson, GH; Nishimura, H; Rosenblum, WI | 1 |
| Slivjak, MJ; Smith, EF | 2 |
| Durham, SK; Selig, WM; Tocker, JE; Welton, AF | 1 |
| Breslow, R; Cheng, JB; Conklyn, MJ; Pillar, JS; Shirley, JT; Showell, HJ | 1 |
| Bernstein, PR; Handley, DA; Harris, KE; Krell, RD; Patterson, R; Saunders, RN | 1 |
| Auen, MA; Englebach, IM; Hand, JM; Kreft, AF; Musser, JH; Schwalm, SF | 1 |
| Mong, S; O'Sullivan, BP | 1 |
| Aharony, D; Catanese, CA; Falcone, RC | 1 |
| Aharony, D; Giles, RE; Krell, RD; Kusner, EJ | 1 |
| Aharony, D; Redkar-Brown, DG | 1 |
| Giles, RE; Keith, RA; Krell, RD; Snyder, DW; Yee, YK | 1 |
| Giles, RE; Krell, RD; Snyder, DW; Yee, YK | 1 |
| Aharony, D; Falcone, RC; Krell, RD | 1 |
| Aharony, D; Falcone, RC; Giles, RE; Hesp, B; Krell, RD; Yee, YK | 1 |
| Buckner, CK; Castleman, WL; Saban, R; Will, JA | 1 |
| Cloud, ML; Fleisch, JH; Marshall, WS | 1 |
| Harris, KE; Krell, RD; Patterson, R | 1 |
| Krasnopolsky, L; Lee, JG; Levin, RM; Longhurst, PA; Wein, AJ | 1 |
| Buckner, CK; Conklin, R; Doran, O; Fishleder, RI; Graziano, FM; Will, JA | 1 |
| Abram, TS; Cuthbert, NJ; Gardiner, PJ; Jennings, MA; Maxey, RJ; Norman, P; Thompson, AM; Tudhope, SR | 1 |
| Abram, TS; Cuthbert, NJ; Gardiner, PJ; Norman, P; Tudhope, SR | 1 |
| Arakawa, H; Kawikova, I; Lindén, A; Löfdahl, CG; Lötvall, J; Skoogh, BE | 1 |
| Falk, A; Larsson, A; Risberg, B; Schützer, KM | 1 |
| Bahl, AK; Clayton, NM; Harman, IW; Strong, P; Trevethick, MA | 1 |
| Andresen, CJ; Smith, WB; Swindell, AC; Turner, CR; Watson, JW | 1 |
| Allen, SP; Chester, AH; Dashwood, MR; Piper, PJ; Tadjkarimi, S; Yacoub, MH | 1 |
| Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB | 1 |
| Bosnjak, ZJ; Coon, RL; Tudorić, N | 1 |
| Ellis, JL; Undem, BJ | 1 |
| Gulbins, E; Rauterberg, EW; Schlottmann, K; Steinhausen, M | 1 |
| Allen, SP; Chester, AH; Collins, M; Dashwood, MR; Piper, PJ; Tadjkarimi, S; Yacoub, MH | 1 |
| Arakawa, H; Hayes, J; Kawikova, I; Löfdahl, CG; Lötvall, J; Morikawa, A; Skoogh, BE | 1 |
| Ahn, CM; Saldeen, T; Sandler, H | 1 |
| Bäck, M; Dahlén, SE; Jonsson, EW | 1 |
| Bonewald, LF; Chen, D; Gallwitz, W; Garcia, C; Kirchen, M; Mundy, GR; Qiao, M | 1 |
| Brink, C; Gascard, JP; Gorenne, I; Labat, C | 1 |
| Amemiya, T; Fujimura, M; Kita, T; Matsuda, T; Myou, S; Tachibana, H | 1 |
| Behar, J; Biancani, P; Jain, MK; Kim, N; Mangannan, V; Rich, H; Sohn, UD | 1 |
| Berend, N; Matheson, MJ; McClean, MA; Rynell, AC | 1 |
| Capra, V; Keppler, D; Mezzetti, M; Nicosia, S; Ragnini, D; Rovati, GE | 1 |
| Dahlén, SE; Rosenqvist, U; Wikström Jonsson, E | 1 |
| Nally, JE; Pitt, CM | 1 |
| Takami, M; Tsukada, W | 1 |
| Dahlén, SE; Larsson, L; Sydbom, A | 1 |
| Tachibana, H | 1 |
| Bäck, M; Cotgreave, IA; Dahlén, SE; Kumlin, M | 1 |
2 review(s) available for indazoles and ici 198615
| Article | Year |
|---|---|
Eicosanoids as mediators and modulators of inflammation.
Topics: Animals; Antigens; Dicarboxylic Acids; Eicosanoids; Indazoles; Indoles; Inflammation; Leukotrienes; SRS-A | 1991 |
A brief review of preclinical and clinical studies with LY171883 and some comments on newer cysteinyl leukotriene receptor antagonists.
Topics: Acetophenones; Animals; Asthma; Azoles; Bronchi; Chromones; Dicarboxylic Acids; Drug Evaluation; Drug Evaluation, Preclinical; Guinea Pigs; Haplorhini; Humans; Indazoles; Leukotriene E4; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Tetrazoles | 1988 |
66 other study(ies) available for indazoles and ici 198615
| Article | Year |
|---|---|
Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides.
Topics: Animals; Benzimidazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Indoles; Muscle, Smooth; Phenylcarbamates; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Structure-Activity Relationship; Sulfonamides; Thiophenes; Tosyl Compounds | 1990 |
Evaluation of a leukotriene receptor antagonist in prevention of hyperoxic lung injury in newborn rabbits.
Topics: Animals; Free Radicals; Indazoles; Lung; Lung Injury; Neutrophils; Oxygen; Pulmonary Edema; Rabbits; Receptors, Immunologic; Receptors, Leukotriene | 1992 |
Guinea pig gall bladder contains a single peptide leukotriene receptor which resembles that present in human conducting airway smooth muscle.
Topics: Animals; Gallbladder; Guinea Pigs; Humans; Indazoles; Lung; Male; Muscle Contraction; Muscle, Smooth; Receptors, Immunologic; Receptors, Leukotriene; Signal Transduction; SRS-A | 1992 |
Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma.
Topics: Asthma; Binding Sites; Chromones; Dicarboxylic Acids; Humans; Indazoles; Kinetics; Lung; Receptors, Immunologic; Receptors, Leukotriene; Software; SRS-A; Thiazoles | 1992 |
ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615.
Topics: Anesthesia, Intravenous; Animals; Bronchoconstriction; Dogs; Dose-Response Relationship, Drug; Endothelins; Indazoles; Indomethacin; SRS-A | 1992 |
Gonadotropin releasing hormone activates the lipoxygenase pathway in cultured pituitary cells: role in gonadotropin secretion and evidence for a novel autocrine/paracrine loop.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Eicosanoids; Exocytosis; Gonadotropin-Releasing Hormone; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indazoles; Leukotrienes; Lipoxygenase; Lipoxygenase Inhibitors; Luteinizing Hormone; Pituitary Gland; Rats; Rats, Inbred Strains; Second Messenger Systems; Secretory Rate; Signal Transduction | 1992 |
Possible existence of leukotriene D4 receptors and mechanism of their signal transduction in human polymorphonuclear leukocytes.
Topics: Binding, Competitive; Calcium; Cell Membrane; Enzyme Activation; Humans; Indazoles; Inositol Phosphates; Kinetics; Neutrophils; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene; Signal Transduction; SRS-A; Tritium | 1991 |
Characterization of the leukotriene D4 receptor in hyperreactive rat lung.
Topics: Animals; Chromatography, High Pressure Liquid; Hypersensitivity; In Vitro Techniques; Indazoles; Kinetics; Lung; Male; Propionates; Proteins; Quinolines; Radioligand Assay; Rats; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1991 |
Evidence for leukotriene D4 receptors in guinea pig left atria.
Topics: Animals; Cell Membrane; Chromatography, High Pressure Liquid; Guinea Pigs; Heart Atria; Indazoles; Male; Radioligand Assay; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Tritium | 1991 |
Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes.
Topics: Animals; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Indazoles; Isoxazoles; Leukotrienes; Lung; Magnesium; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1991 |
Leukotriene D4 increases both the force of contraction and polyphosphoinositide formation in guinea-pig papillary muscle.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Inositol Phosphates; Isoproterenol; Lung; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphatidylinositols; SRS-A | 1991 |
Further evidence that leukotrienes are the major mediators of allergic constriction in human bronchi.
Topics: Allergens; Antibodies, Anti-Idiotypic; Asthma; Bronchi; Bronchoconstriction; Histamine Antagonists; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Indazoles; Indoles; Leukotriene Antagonists; Leukotrienes; Male; Middle Aged | 1991 |
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity.
Topics: Animals; Chemical Phenomena; Chemistry; Chromones; Guinea Pigs; Indazoles; Lung; Quinolines; Radioligand Assay; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Structure-Activity Relationship | 1991 |
Effect of ICI 198,615, SK+F 104,353, MK-571 and CGP45715A on cysteinyl leukotriene-induced responses in guinea-pig heart.
Topics: Animals; Benzopyrans; Coronary Vessels; Dicarboxylic Acids; Guinea Pigs; Indazoles; Male; Myocardial Contraction; Propionates; Prostaglandin Endoperoxides, Synthetic; Quinolines; SRS-A; Vascular Resistance; Vasoconstrictor Agents | 1991 |
PAF-induced bowel necrosis. Effects of vasodilators.
Topics: Alprostadil; Animals; Hydralazine; Hypotension; Indazoles; Intestinal Diseases; Leukopenia; Male; Mesenteric Arteries; Necrosis; Nitroglycerin; Phenoxybenzamine; Platelet Activating Factor; Prazosin; Rats; Rats, Inbred Strains; SRS-A; Vasodilator Agents | 1991 |
Post soluble binding to the leukotriene D4 receptor from guinea pig lung membranes.
Topics: Animals; Binding, Competitive; Cell Membrane; Chromatography, Gel; Detergents; Guinea Pigs; Indazoles; Kinetics; Ligands; Lung; Pyrazoles; Receptors, Immunologic; Receptors, Leukotriene; Solubility; SRS-A | 1990 |
Specific binding of 3H-ICI 198,615, a potent LTD4 antagonist, to guinea pig cardiac ventricular membranes.
Topics: Animals; Cations, Divalent; Guinea Pigs; In Vitro Techniques; Indazoles; Kinetics; Myocardium; Pyrazoles; Radioligand Assay; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1990 |
Pharmacologic characterization of the contractile activity of peptide leukotrienes in guinea-pig pulmonary artery.
Topics: Acetophenones; Animals; Borates; Drug Synergism; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Artery; Receptors, Immunologic; Receptors, Leukotriene; Serine; SRS-A; Tetrazoles | 1990 |
Evidence for two leukotriene receptor types in the guinea-pig isolated ileum.
Topics: Animals; Borates; Chromones; Cyclooxygenase Inhibitors; Cysteine; Dicarboxylic Acids; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene E4; Male; Receptors, Immunologic; Receptors, Leukotriene; Serine; SRS-A; Stereoisomerism | 1990 |
Assessment of leukotriene D4 receptor antagonists.
Topics: Animals; Binding, Competitive; Cell Membrane; Guinea Pigs; Indazoles; Kinetics; Lung; Male; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1990 |
Leukotriene constriction of mouse pial arterioles in vivo is endothelium-dependent and receptor-mediated.
Topics: Animals; Arterioles; Endothelium, Vascular; Indazoles; Mice; Pia Mater; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Vasoconstriction | 1990 |
ICI 198615 is an antagonist of leukotriene C4, leukotriene D4 and leukotriene E4 vasopressor responses in the conscious rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Indazoles; Infusions, Intravenous; Leukotriene E4; Male; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Vasoconstriction | 1990 |
Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists.
Topics: Animals; Azepines; Blood Pressure; Bronchi; Bronchoalveolar Lavage Fluid; Dexamethasone; Enzyme Inhibitors; Guinea Pigs; Humans; Indazoles; Indomethacin; Lung; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pressure; Propranolol; Pyrilamine; SRS-A; Trachea; Triazoles | 1990 |
Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs.
Topics: Animals; Antigens; Guinea Pigs; Immunoglobulin G; Indazoles; Isoxazoles; Lung; Male; Platelet Activating Factor; SRS-A; Thromboxane B2 | 1990 |
Evidence for high and low affinity leukotriene D4 receptors mediating vascular responses in the conscious rat.
Topics: Animals; Blood Pressure; Dicarboxylic Acids; Indazoles; Male; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1989 |
Effects of combined receptor antagonists of leukotriene D4 (LTD4) and platelet-activating factor (PAF) on rhesus airway responses to LTD4, PAF and antigen.
Topics: Animals; Ascaris; Asthma; Drug Therapy, Combination; Female; Immunoglobulin E; Indazoles; Macaca mulatta; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyrazoles; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1989 |
Pharmacological characterization using selected antagonists of the leukotriene receptors mediating contraction of guinea-pig trachea.
Topics: Acetophenones; Airway Resistance; Animals; Chromones; Guinea Pigs; Hydroxyquinolines; In Vitro Techniques; Indazoles; Male; Phenyl Ethers; Quinolines; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Tetrazoles; Trachea | 1989 |
Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states.
Topics: Animals; Binding, Competitive; Cell Membrane; Guinea Pigs; Indazoles; Kinetics; Lung; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Structure-Activity Relationship | 1989 |
Guanyl-5'-yl-lmidodiphosphate regulation of ligand binding to LTD4 receptors on guinea pig lung membranes.
Topics: Animals; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene E4; Lung; Receptors, Immunologic; Receptors, Leukotriene; SRS-A | 1989 |
Biochemical and pharmacological characterization of ICI 198,615: a peptide leukotriene receptor antagonist.
Topics: Animals; Bronchi; Capillary Permeability; gamma-Glutamyltransferase; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene E4; Lipoxygenase Inhibitors; Lung; Male; Ovalbumin; Pyrazoles; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Thromboxane B2 | 1989 |
Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615.
Topics: Animals; Antigens; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; Pyrilamine; SRS-A; Trachea | 1989 |
In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist.
Topics: Acetophenones; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Humans; In Vitro Techniques; Indazoles; Male; Muscle, Smooth; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tetrazoles; Trachea | 1987 |
In vivo pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist.
Topics: Aerosols; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Indazoles; Injections, Intravenous; Lung; Male; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A | 1987 |
Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Indazoles; Lung; Male; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tritium | 1987 |
Biochemical and pharmacological characterization of the binding of the selective peptide-leukotriene antagonist, 3H-ICI 198,615, to leukotriene D4 receptors in guinea-pig lung membranes.
Topics: Animals; Cations, Divalent; Cell Membrane; Chromatography, High Pressure Liquid; Guinea Pigs; Indazoles; Lung; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A | 1988 |
Analysis of leukotriene receptor antagonists on isolated human intralobar airways.
Topics: Acetophenones; Azoles; Barium; Bronchi; Chromones; Humans; Indazoles; Muscle Contraction; Muscle, Smooth; Pyrazoles; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Tetrazoles | 1988 |
Effect of a leukotriene D4 (LTD4) antagonist on LTD4 and ascaris antigen-induced airway responses in rhesus monkeys.
Topics: Animals; Antigens, Helminth; Ascaris; Dose-Response Relationship, Immunologic; Female; Indazoles; Macaca mulatta; Male; Pyrazoles; Respiratory Physiological Phenomena; Respiratory System; SRS-A | 1988 |
Effects of the peptide leukotriene receptor antagonist ICI 198,615 on the in vivo and in vitro changes in guinea pig bladder function which occur after sensitization with ovalbumin.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene Antagonists; Muscle Contraction; Ovalbumin; Pyrilamine; SRS-A; Urinary Bladder; Urodynamics | 1995 |
Pharmacologic modulation of the influence of the epithelium on immunologic- and nonimmunologic-induced histamine release and contraction in guinea pig superfused tracheal strips.
Topics: Animals; Epithelium; Female; Guinea Pigs; Histamine Release; Hydroxyurea; In Vitro Techniques; Indazoles; Indomethacin; Muscle Contraction; Ovalbumin; Pyrilamine; Trachea; Tubocurarine | 1993 |
BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes.
Topics: Animals; Binding, Competitive; Bronchi; Dicarboxylic Acids; Ferrets; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene C4; Leukotriene D4; Lung; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propionates; Quinolines; Rats; Rats, Wistar; Receptors, Immunologic; Sheep; Spleen; SRS-A; Trachea | 1994 |
Characterisation of leukotriene receptors on rat lung strip.
Topics: Animals; Dicarboxylic Acids; In Vitro Techniques; Indazoles; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Propionates; Quinolines; Rats; Rats, Wistar; Receptors, Leukotriene; SRS-A | 1994 |
Role of eicosanoids in airflow obstruction and airway plasma exudation induced by trimellitic anhydride-conjugate in guinea-pigs 3 and 8 weeks after sensitization.
Topics: Airway Resistance; Animals; Capillary Permeability; Dioxanes; Guinea Pigs; Indazoles; Leukotrienes; Male; Phthalic Anhydrides; Pyrilamine; Respiratory Function Tests; Serum Albumin; Thromboxane A2 | 1994 |
Leukotriene receptor antagonism prevents lung protein leakage and hypoxaemia in a septic cat model.
Topics: Analysis of Variance; Animals; Capillary Permeability; Cats; Diethylcarbamazine; Disease Models, Animal; Hypoxia; Indazoles; Leukotriene Antagonists; Leukotrienes; Lung; Organ Size; Shock, Septic | 1994 |
Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the re-fed rat.
Topics: Administration, Oral; Animals; Benzopyrans; Female; Indazoles; Indoles; Indomethacin; Injections, Subcutaneous; Leukotriene Antagonists; Leukotriene B4; Microscopy, Electron; Pyloric Antrum; Rats; SRS-A; Stomach Ulcer | 1994 |
Leukotriene D4 receptor antagonism reduces airway hyperresponsiveness in monkeys.
Topics: Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Indazoles; Leukocyte Count; Leukocytes; Leukotriene Antagonists; Macaca fascicularis; Male; Membrane Proteins; Receptors, Leukotriene; SRS-A | 1994 |
Preferential vasoconstriction to cysteinyl leukotrienes in the human saphenous vein compared with the internal mammary artery. Implications for graft performance.
Topics: Adult; Aged; Autoradiography; Blood Vessel Prosthesis; Endothelium, Vascular; Humans; Indazoles; Leukotriene E4; Leukotrienes; Mammary Arteries; Middle Aged; Rest; Saphenous Vein; SRS-A; Vasoconstriction; Vasomotor System | 1994 |
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Hydroxyurea; Indazoles; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Pyrilamine; SRS-A; Trachea | 1994 |
Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4.
Topics: Anaphylaxis; Animals; Antigens; Dinoprost; Diphenhydramine; Glycopeptides; Guinea Pigs; Histamine; In Vitro Techniques; Indazoles; Leukotriene D4; Muscle Contraction; Muscle, Smooth; Neprilysin; Prostaglandin D2; SRS-A; Trachea | 1994 |
Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi.
Topics: Bronchi; Chlorpheniramine; Dicarboxylic Acids; Female; Histamine; Humans; Hydroxyurea; In Vitro Techniques; Indazoles; Isometric Contraction; Isotonic Solutions; Leukotriene D4; Lipoxygenase Inhibitors; Male; Middle Aged; Muscle Tonus; Muscle, Smooth; Pyrilamine; SRS-A | 1994 |
Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys.
Topics: Animals; Antibodies; Complement C5a; Female; Glomerular Filtration Rate; Hydronephrosis; Indazoles; Neutrophils; Phenylacetates; Platelet Activating Factor; Rats; Rats, Wistar; Recombinant Proteins; Reference Values; Renal Circulation; SRS-A; Sulfonamides; Thromboxanes; Vasoconstriction | 1993 |
Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4.
Topics: Adolescent; Adult; Arteriosclerosis; Child; Child, Preschool; Coronary Vessels; Endothelium, Vascular; Humans; In Vitro Techniques; Indazoles; Indomethacin; Leukocytes; Middle Aged; SRS-A; Vasoconstriction | 1993 |
Role of arachidonic acid metabolites in airway responses induced by trimellitic anhydride in actively sensitized guinea pigs.
Topics: Airway Resistance; Animals; Arachidonic Acid; Bronchi; Evans Blue; Exudates and Transudates; Guinea Pigs; Immunization; Indazoles; Indomethacin; Ketanserin; Male; Methacrylates; Permeability; Phthalazines; Phthalic Anhydrides; Pyrilamine; Respiratory Hypersensitivity; SRS-A; Thromboxane-A Synthase | 1993 |
Beneficial effects of a leukotriene receptor antagonist on thrombin-induced pulmonary edema in the rat.
Topics: Animals; Indazoles; Leukotriene Antagonists; Lung; Male; Organ Size; Peroxidase; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Thrombin | 1995 |
The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Prostaglandin Endoperoxides, Synthetic; Receptors, Leukotriene; SRS-A; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Effects of synthetic peptido-leukotrienes on bone resorption in vitro.
Topics: Animals; Binding, Competitive; Bone and Bones; Bone Neoplasms; Bone Resorption; Calcium; Cells, Cultured; Chickens; Female; Giant Cell Tumor of Bone; Humans; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Membrane Proteins; Mice; Organ Culture Techniques; Osteoclasts; Radioligand Assay; Rats; Receptors, Leukotriene; Tumor Cells, Cultured | 1996 |
Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation.
Topics: Antigens; Asthma; Bronchi; Bronchodilator Agents; Cell Separation; Humans; Hydroxy Acids; Indazoles; Leukotriene D4; Muscle, Smooth; Norepinephrine; Propionates; Pulmonary Veins; Quinolines | 1996 |
Peptide leukotrienes mediate acetaldehyde-induced bronchial hyper-responsiveness in guinea-pigs.
Topics: Acetaldehyde; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chromones; Diphenhydramine; Guinea Pigs; Indazoles; Leukotriene Antagonists; Leukotrienes; Male; Methacholine Chloride | 1997 |
Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis.
Topics: Acetylcholine; Animals; Arachidonic Acid; Cats; Diglycerides; Drug Synergism; Esophagitis; Esophagus; Female; Indazoles; Leukotrienes; Male; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2 | 1997 |
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents | 1997 |
Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma.
Topics: Binding Sites; Dicarboxylic Acids; GTP Phosphohydrolases; Humans; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Lung; Membrane Proteins; Receptors, Leukotriene; Tritium | 1998 |
Agonist and antagonist activities of the leukotriene analogue BAY u9773 in guinea pig lung parenchyma.
Topics: Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Membrane Proteins; Receptors, Leukotriene; Receptors, Thromboxane; SRS-A; Time Factors | 1998 |
Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes?
Topics: Angiotensin II; Animals; Bronchi; Cattle; Dose-Response Relationship, Drug; Drug Synergism; Endothelin-1; Indazoles; Indoles; Leukotriene Antagonists; Leukotriene D4; Vasoconstrictor Agents | 1999 |
A possible involvement of thromboxane A2 and peptide leukotrienes in hyperresponsiveness of Sephadex-treated rat lung parenchyma.
Topics: Animals; Anti-Asthmatic Agents; Benzoquinones; Dextrans; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Heptanoic Acids; Imidazoles; Indazoles; Indomethacin; Leukotrienes; Lung; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Serotonin; Tetrahydronaphthalenes; Thromboxane A2 | 1999 |
Selective effects of antileukotrienes on leukotriene and histamine release in human dispersed lung cells.
Topics: Histamine H1 Antagonists; Histamine Release; Humans; Hydroxyurea; Indazoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Lung Neoplasms; Pyrilamine; Quinolines | 1999 |
[The role of lipid mediators in bronchial hyperresponsiveness and airway eosinophil accumulation induced by antigen challenge in guinea pigs].
Topics: Animals; Azepines; Bridged Bicyclo Compounds; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophils; Fatty Acids, Monounsaturated; Guinea Pigs; Indazoles; Leukotriene Antagonists; Male; Membrane Proteins; Platelet Membrane Glycoproteins; Prostaglandin Antagonists; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Receptors, Thromboxane; Triazoles | 2000 |
An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea.
Topics: Animals; Borates; Cysteine; Dicarboxylic Acids; Dose-Response Relationship, Drug; Glutathione; Guinea Pigs; In Vitro Techniques; Indazoles; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Male; Membrane Proteins; Muscle Contraction; Propionates; Quinolines; Receptors, Leukotriene; Serine; SRS-A; Trachea | 2001 |