Compounds > indazoles
Page last updated: 2024-08-21

indazoles and gsk-2816126

indazoles has been researched along with gsk-2816126 in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Beijnen, JH; Buil, LC; de Gooijer, MC; Li, G; van Tellingen, O; Zhang, P1
Kim, KH; Roberts, CW1
Huang, J; Huang, S; Li, QJ; Long, H; Symonds, ALJ; Tang, X; Wan, YY; Wang, Z; Xu, L; Zhou, J; Zhu, B1
Akritidou, MA; Anagnostopoulos, A; Belloni, D; Chartomatsidou, E; Ferrero, E; Ghia, P; Kotta, K; Ntoufa, S; Papakonstantinou, N; Rosenquist, R; Rovida, A; Stamatopoulos, K; Stavroyianni, N; Trangas, T1
Bugide, S; Green, MR; Gupta, R; Wajapeyee, N1

Reviews

1 review(s) available for indazoles and gsk-2816126

ArticleYear
Targeting EZH2 in cancer.
    Nature medicine, 2016, Volume: 22, Issue:2

    Topics: Benzamides; Biphenyl Compounds; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Indoles; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasms; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Pyridones

2016

Other Studies

4 other study(ies) available for indazoles and gsk-2816126

ArticleYear
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
    International journal of cancer, 2015, Oct-15, Volume: 137, Issue:8

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Benzamides; Biological Availability; Biphenyl Compounds; Blood-Brain Barrier; Cell Line; Dogs; Drug Evaluation, Preclinical; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Indoles; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Morpholines; Polycomb Repressive Complex 2; Pyridones

2015
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation.
    Nature communications, 2019, 06-03, Volume: 10, Issue:1

    Topics: Animals; Cell Differentiation; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Hematopoietic Stem Cells; Histone Code; Histones; In Vitro Techniques; Indazoles; Indoles; Inflammatory Bowel Diseases; Methylation; Mice; Myeloid-Derived Suppressor Cells; Pyridones

2019
Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia.
    Blood advances, 2019, 06-25, Volume: 3, Issue:12

    Topics: Adenine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; B-Lymphocytes; Bridged Bicyclo Compounds, Heterocyclic; Down-Regulation; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histones; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Piperidines; Purines; Pyrazoles; Pyridones; Pyrimidines; Quinazolinones; Signal Transduction; Sulfonamides; Tumor Microenvironment

2019
EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 07-27, Volume: 118, Issue:30

    Topics: Animals; Benzopyrans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chemokine CXCL10; Chemokines; Decitabine; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Indazoles; Indoles; Killer Cells, Natural; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Phenols; Pyridones; Sulfones; Triazoles

2021