indazoles has been researched along with gsk 2334470 in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 17 (89.47) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Alessi, DR; Axten, JM; Deyoung, MP; Najafov, A; Sommer, EM | 1 |
| Knight, ZA | 1 |
| Chikh, A; Falasca, M; Maffucci, T; Raimondi, C; Wheeler, AP | 1 |
| Alessi, DR; Najafov, A; Shpiro, N | 1 |
| Bosenberg, M; De, SK; Feng, Y; Kluger, H; Lazova, R; Li, JL; Pellecchia, M; Rickert, R; Ronai, ZA; Ruller, C; Scortegagna, M | 1 |
| Alcántara-Hernández, R; García-Sáinz, JA; Hernández-Méndez, A | 1 |
| Frei, RB; Hammer, A; Heinemann, A; Lippe, IT; Parzmair, GP; Radnai, B; Schuligoi, R; Sturm, EM; Sturm, GJ | 1 |
| Bosenberg, M; Brown, K; Davies, MA; De, SK; Feng, Y; Halaban, R; Langdon, CG; Lau, E; Meeth, K; Pellecchia, M; Platt, JT; Ronai, ZA; Scortegagna, M; Sereduk, C; Stern, DF; Yin, H; Zhang, T | 1 |
| Chen, Y; Han, Z; Hou, X; Qian, Z; Wang, Y; Wu, T; Yuan, J; Zhu, D; Zou, J | 1 |
| Alzari, PM; Biondi, RM; Busschots, K; Gervasio, FL; Herbrand, AK; Hindie, V; Lisa, MN; Neimanis, S; Odadzic, D; Saladino, G; Schulze, JO; Süß, E; Zeuzem, S | 1 |
| Kobayashi, T; Matsumoto, T; Taguchi, K; Watanabe, S | 1 |
| Arteaga, CL; Bauer, JA; Bhola, NE; Dugger, TC; Ericsson, PG; Estrada, MV; Formisano, L; Hutchinson, KE; Jansen, VM; Knudsen, ES; Lee, KM; Moore, PD; Pishvaian, MJ; Pohlmann, PR; Riddle, DA; Sánchez, V; Sanders, ME; Wei, W; Witkiewicz, AK | 1 |
| Huang, X; Liu, H; Qian, W; Wei, J; Xiao, F; Yang, C; You, L | 1 |
| Chinen, Y; Horiike, S; Kobayashi, T; Kuroda, J; Kuwahara-Ota, S; Maegawa, S; Matsumura-Kimoto, Y; Mizuno, Y; Shimura, Y; Takimoto, T; Tanba, K; Taniwaki, M; Tsukamoto, T | 1 |
| Chen, X; Yang, C; Zhang, J; Zhou, F | 1 |
| Ding, H; Fang, S; Feng, J; Han, J; Yu, X | 1 |
| Bragado, MJ; García-Marín, LJ; González-Fernández, L; Macías-García, B | 1 |
| Zhang, X; Zhong, S | 1 |
| Cho, Y; Kim, H; Lee, J | 1 |
19 other study(ies) available for indazoles and gsk 2334470
| Article | Year |
|---|---|
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
Topics: Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Humans; Indazoles; Mice; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Substrate Specificity | 2011 |
For a PDK1 inhibitor, the substrate matters.
Topics: Humans; Indazoles; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Substrate Specificity | 2011 |
A novel regulatory mechanism links PLCγ1 to PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Calcium; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Indazoles; Neoplasm Invasiveness; Phospholipase C gamma; Phosphorylation; Protein Interaction Mapping; Protein Serine-Threonine Kinases; Pyrimidines; RNA, Small Interfering; Signal Transduction; Transfection | 2012 |
Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Drug Resistance, Neoplasm; Enzyme Activation; HEK293 Cells; Humans; Indazoles; Mechanistic Target of Rapamycin Complex 2; Mice; Molecular Sequence Data; Multiprotein Complexes; Mutation; Neoplasms; Phosphatidylinositol Phosphates; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; TOR Serine-Threonine Kinases | 2012 |
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Knockout Techniques; Humans; Indazoles; Lung Neoplasms; Lymphatic Metastasis; Melanoma, Experimental; Mice; Mice, Knockout; Mutation, Missense; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Skin Neoplasms; Tissue Array Analysis | 2014 |
The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cricetinae; Indazoles; Metalloproteases; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Staurosporine; Sulfonamides | 2014 |
Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Active Transport, Cell Nucleus; Animals; Calcium Signaling; CD11b Antigen; Cell Shape; Dinoprostone; Eosinophils; Humans; Indazoles; Methyl Ethers; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Burst; Ribonucleosides; Signal Transduction | 2015 |
PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; Humans; Immediate-Early Proteins; Indazoles; Lymphatic Metastasis; Melanoma; Mice, Knockout; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins B-raf; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Skin; Skin Neoplasms | 2015 |
CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway.
Topics: Action Potentials; Animals; ARNTL Transcription Factors; Calcium Channels, L-Type; Cells, Cultured; Circadian Rhythm; CLOCK Proteins; Guinea Pigs; Heterocyclic Compounds, 3-Ring; Indazoles; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Subunits; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction | 2016 |
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Topics: Adenosine Triphosphate; Allosteric Regulation; Allosteric Site; Aurora Kinases; Binding Sites; HEK293 Cells; Humans; Indazoles; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase | 2016 |
Relationship between PDK1 and contraction in carotid arteries in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Phosphoinositide-Dependent Protein Kinases; Animals; Carotid Arteries; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Serotonin; Signal Transduction; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 2017 |
Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.
Topics: Aminopyridines; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Indazoles; MCF-7 Cells; Mice; Phosphatidylinositol 3-Kinases; Piperazines; Protein Serine-Threonine Kinases; Purines; Pyridines; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Estrogen; Xenograft Model Antitumor Assays | 2017 |
PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Female; Humans; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, SCID; Multiple Myeloma; Purines; Pyrimidines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2017 |
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Aniline Compounds; Cell Line, Tumor; Humans; Indazoles; Lymphoma, Mantle-Cell; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sulfonamides | 2018 |
PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
Topics: Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Leupeptins; Multiple Myeloma; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyrimidines; TOR Serine-Threonine Kinases | 2018 |
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Cell Death; Drug Discovery; Ferric Compounds; HeLa Cells; Humans; Hydroxyquinolines; Indazoles; Iron; Iron Overload; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species | 2018 |
The calcium-sensing receptor regulates protein tyrosine phosphorylation through PDK1 in boar spermatozoa.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Indazoles; Isoquinolines; Male; Naphthalenes; Phenylmethylsulfonyl Fluoride; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Calcium-Sensing; Signal Transduction; Sperm Capacitation; Sperm Motility; Spermatozoa; Sulfonamides; Sus scrofa; Tyrosine | 2019 |
PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Indazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Molecular Structure; Neoplasms, Experimental; PC12 Cells; Pheochromocytoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Structure-Activity Relationship; TOR Serine-Threonine Kinases | 2020 |
PDK1 is a negative regulator of axon regeneration.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Axons; Axotomy; Down-Regulation; Ganglia, Spinal; Indazoles; MAP Kinase Signaling System; Mice; Nerve Regeneration; Pyrimidines; Sciatic Nerve; TRPP Cation Channels; Up-Regulation | 2021 |