Compounds > indazoles
Page last updated: 2024-08-21

indazoles and epz005687

indazoles has been researched along with epz005687 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allain, CJ; Chesworth, R; Copeland, RA; Jin, L; Keilhack, H; Klaus, CR; Knutson, SK; Kuntz, KW; Majer, CR; Moyer, MP; Olhava, EJ; Pollock, RM; Raimondi, A; Richon, VM; Sacks, JD; Scott, MP; Smith, JJ; Sneeringer, CJ; Song, J; Warholic, NM; Wigle, TJ1
Cao, JJ; Chen, D; DU, XH; Li, SY; Liu, XH; Ma, JX; Pei, RZ; Sha, KY; Tang, SH; Zhang, PS1
Beijnen, JH; Buil, LC; de Gooijer, MC; Li, G; van Tellingen, O; Zhang, P1
Kim, KH; Roberts, CW1
Chen, L; Li, F; Sun, L; Wang, Y; Wu, Y1
Andrews, C; Biron, VL; Côté, DW; Harris, J; Idris, S; Kostiuk, M; Lindsay, C; O'Connell, DA; Seikaly, H1
Fang, K; Li, ZH; Ren, DH; Shi, ZL; Sun, J; Zhang, JY1
Feng, L; Hong, F; Zhang, L; Zhao, M1

Reviews

1 review(s) available for indazoles and epz005687

ArticleYear
Targeting EZH2 in cancer.
    Nature medicine, 2016, Volume: 22, Issue:2

    Topics: Benzamides; Biphenyl Compounds; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Humans; Indazoles; Indoles; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasms; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Pyridones

2016

Other Studies

7 other study(ies) available for indazoles and epz005687

ArticleYear
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
    Nature chemical biology, 2012, Volume: 8, Issue:11

    Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Cell Proliferation; Dose-Response Relationship, Drug; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histones; Humans; Indazoles; Lymphoma; Lysine; Methylation; Molecular Structure; Point Mutation; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship

2012
[Effects of H3K27 methylation inhibitor EPZ005687 on apoptosis, proliferation and cell cycle of U937 cells and normal CD34 positive cells].
    Zhongguo shi yan xue ye xue za zhi, 2014, Volume: 22, Issue:6

    Topics: Antigens, CD34; Apoptosis; Cell Cycle; Cell Proliferation; Humans; Indazoles; Methylation; Pyridones; U937 Cells

2014
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
    International journal of cancer, 2015, Oct-15, Volume: 137, Issue:8

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Benzamides; Biological Availability; Biphenyl Compounds; Blood-Brain Barrier; Cell Line; Dogs; Drug Evaluation, Preclinical; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Indazoles; Indoles; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Morpholines; Polycomb Repressive Complex 2; Pyridones

2015
The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway.
    Scientific reports, 2016, 08-19, Volume: 6

    Topics: Animals; beta Catenin; Cell Differentiation; Chondrocytes; Chondrogenesis; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Glycoproteins; Humans; Indazoles; Intracellular Signaling Peptides and Proteins; Mice; Osteoarthritis; Promoter Regions, Genetic; Pyridones; Wnt Signaling Pathway

2016
Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2016, Oct-28, Volume: 45, Issue:1

    Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Humans; Immunohistochemistry; Indazoles; Oropharyngeal Neoplasms; Papillomavirus Infections; Polymerase Chain Reaction; Pyridones; Tumor Cells, Cultured

2016
EZH2 Inhibition Ameliorates Transverse Aortic Constriction-Induced Pulmonary Arterial Hypertension in Mice.
    Canadian respiratory journal, 2018, Volume: 2018

    Topics: Animals; Aorta; Arterial Pressure; Constriction; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indazoles; Lung; Male; Mice; Pulmonary Artery; Pyridones; Reactive Oxygen Species; Superoxide Dismutase-1

2018
Inhibition of Ezh2 In Vitro and the Decline of
    Stem cells and development, 2019, 05-15, Volume: 28, Issue:10

    Topics: Animals; Cell Differentiation; Cells, Cultured; Dopaminergic Neurons; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Indazoles; Lysine; Mesencephalon; Methylation; Neural Stem Cells; Nuclear Receptor Subfamily 4, Group A, Member 2; Promoter Regions, Genetic; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tyrosine 3-Monooxygenase

2019