Page last updated: 2024-08-21

indazoles and cyclic gmp

indazoles has been researched along with cyclic gmp in 146 studies

Research

Studies (146)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	32 (21.92)	18.2507
2000's	93 (63.70)	29.6817
2010's	21 (14.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC	2
Brain, SD; Kajekar, R; Moore, PK	1
Cheng, ZJ; Guh, JH; Kuo, SC; Lee, FY; Yu, SM	1
Dray, A; Patel, IA; Rueff, A; Urban, L	1
Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U	1
Bauersachs, J; Busse, R; Kast, R; Mülsch, A; Schäfer, A; Stasch, JP	1
Ko, FN; Teng, CM; Wu, CC	1
Iadecola, C; Yang, G	1
Carey, RM; Siragy, HM	1
Brown, RJ; Diaz, J; Gukovskaya, AC; Lau, KS; Muallem, S; Pandol, SJ; Xu, X; Zeng, W	1
Armstead, WM; Wilderman, MJ	1
Förstermann, U; Gath, I; Nawrath, H; Wegener, JW	1
de Vente, J; Prickaerts, J; Smits, JF; Steinbusch, HW	1
Ayata, C; Huang, PL; Meng, W; Moskowitz, MA; Waeber, C	1
Handy, RL; Moore, PK	1
Bryan, RM; Pelligrino, DA; Wang, Q	1
Goto, T; Ichinose, F; Mi, WD; Miyazaki, M; Morita, S; Onouchi, T	1
Bladen, C; El-Husseini, AE; Reiner, PB; Vincent, SR; Williams, JA	1
La, M; Schmidt, HH; Weeger, M; Zabel, U	1
Chalimoniuk, M; Strosznajder, J	1
Friebe, A; Koesling, D; Müllershausen, F; Schultz, G; Smolenski, A; Walter, U	1
Corbalán, R; Felipo, V; Miñana, MD; Montoliu, C; Teng, CM	1
Haddad, E; Johns, RA; Pajewski, TN	1
Cassetti, A; Consolo, S; Uboldi, MC	1
Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U	1
Pelligrino, DA; Santizo, RA; Wang, Q	1
Hwang, TL; Teng, CM; Wu, CC	1
Kuo, SC; Lee, FY; Teng, CM; Wu, CC	1
Hobbs, AJ; Hussain, MB; MacAllister, RJ	1
Friebe, A; Koesling, D; Mergia, E; Russwurm, M	1
Linz, W; Malinski, T; Ruetten, H; Schindler, U; Schoenafinger, K; Strobel, H; Wiemer, G; Wohlfart, P	1
Mullan, M; Paris, D; Town, T	1
Furukawa, S; Hiramatsu, M; Kameyama, T; Karasawa, K; Mamiya, T; Nabeshima, T; Noda, A; Noda, Y; Yamada, K	1
Bicker, G; Seidel, C	1
Löscher, W; Löschmann, PA; Richter, A	1
Cadnapaphornchai, M; Carter, EP; Knotek, M; Martin, PY; Morris, K; Ohara, M; Rogachev, B; Schrier, RW; Xu, L	1
Chapman, GB; Durante, W; Evans, AJ; Peyton, KJ; Schafer, AI; Tulis, DA	1
Koesling, D; Mayer, B; Schmidt, K; Schrammel, A	1
Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K; O'Reilly, DA	1
Chiang, HT; Li, HF; Wu, SN	1
Bae, JM; Choi, E; Chun, YS; Kim, MS; Park, JW; Teng, CM; Yeo, EJ	1
Bruckdorfer, KR; Friebe, A; Koesling, D; Naseem, KM; Sabetkar, M; Tullett, JM	1
Corbalán, R; Córdoba, J; Felipo, V; López-Talavera, J; Martinez, L; Monfort, P	1
Eto, S; Hashimoto, O; Ikeda, M; Inada, Y; Ito, A; Kaizu, K; Qie, YL; Suzuka, K; Takagi, I; Tanaka, Y; Uriu, K	1
Becker, C; Bergemann, C; Fischer, Y; Graf, B; Hamidizadeh, M; Löken, C	1
Chang, LC; Huang, LJ; Kuo, SC; Wang, JP	1
Chai, CY; Su, CK; Wang, Y; Wu, WC	1
Ferrero, R; Torres, M	1
Garthwaite, G; Garthwaite, J; Goodwin, DA; Neale, S; Riddall, D	1
Leffler, CW; Zhang, Y	1
Alajuuma, P; Kotikoski, H; Laippala, P; Moilanen, E; Oksala, O; Salmenperä, P; Vapaatalo, H	1
Bohl Masters, KS; Durante, W; Evans, AJ; Lipke, EA; Peyton, KJ; Schafer, AI; Schiesser, RL; Tulis, DA; West, JL	1
Allen, JC; Kahn, AM; Zhang, S	1
Fujimura, S; Hisa, H; Nakamura, K; Satoh, S; Suzuki-Kusaba, M; Tanioka, H; Yoshida, M	1
Brioni, JD; Chang, R; Hsieh, G; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M; Terranova, MA	1
Chang, LC; Hsu, MF; Huang, LJ; Kuo, SC; Raung, SL; Wang, JP	1
Ralevic, V	1
Heiberg, IL; Rosenberg, R; Wegener, G	1
Ndisang, JF; Wang, R; Zhao, W	1
Homer, KL; Wanstall, JC	1
Brioni, JD; Chang, R; Hsieh, GC; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M	1
Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP	1
Che, Y; Li, CG; Rand, MJ	1
Bito, H; Iwamoto, T; Katoh, T; Kobayashi, S; Sato, S	1
Hung, CC; Lee, SY; Li, SY; Lin, MJ; Lin, RH; Lin-Shiau, SY; Su, CC; Su, MC; Tan, CT	1
Bredt, DS	1
Guh, JH; Hwang, TL; Teng, CM; Wu, CC	1
Ho, PY; Hsu, HK; Juan, SH; Lee, WS; Liang, YC; Lin, CH; Teng, CM	1
Caffrey, JL; Farias, M; Jackson, K; Johnson, M	1
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP	1
DiJulio, DH; Jacobson, KL; Singh, JC; Watson, EL	1
Cheng, SJ; Hung, HW; Hwang, TL; Kao, SH; Teng, CM; Wu, CC	1
Chan, JY; Chan, SH; Chang, AY	1
Adragna, NC; Di Fulvio, M; Lauf, PK	1
Bhopale, VM; Buerk, DG; Cameron, B; Fisher, D; Thom, SR; Zhang, J	1
Gao, H; Kaminski, A; Morgan, NG	1
Balashova, N; Beuve, A; Chang, FJ; Lamothe, M; Shirokov, R	1
Friebe, A; Koesling, D; Mullershausen, F; Russwurm, M	1
Chun, YS; Park, JW; Yeo, EJ	1
Baughman, VL; Gavrilyuk, V; Pelligrino, DA; Wolde, HM; Xu, HL	1
Imai, A; Komine, N; Nashida, T; Shimomura, H; Shimooka, S; Tanaka, S	1
Tulis, DA	1
Chang, MS; Chen, BC; Lee, WS; Lin, CH; Sheu, JR	1
Delago, A; Elphick, MR; Ott, SR	1
Cogolludo, A; Gonzalez-Luis, G; Lodi, F; Lopez-Farre, A; Moreno, L; Perez-Vizcaino, F; Tamargo, J; Villamor, E	1
Chen, JY; Lapolt, PS; Stewart, RL; Tafoya, MA	1
Chang, YL; Chen, HL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Pan, SL; Teng, CM; Wang, SW	1
Cole, KR; Lanning, KM; Linder, AE; McCluskey, LP; Webb, RC	1
Cheng, CY; Lee, NP; Mruk, DD; Wong, CH	1
Chang, JH; Chang, YL; Cheng, FC; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Peng, CY; Teng, CM	1
Bothma, T; Harvey, BH; Nel, A; Stein, DJ; Wegener, G	1
Elsner, N; Ganter, GK; Günther, C; Heinrich, R; Kunst, M; Lakes-Harlan, R; Wenzel, B	1
Chen, YM; Chiang, WC; Hsieh, BS; Lin, SL; Teng, CM; Tsai, TJ	1
Bagcivan, I; Cetin, A; Cetin, M; Demirkoprulu, N; Karadas, B; Kaya, T; Soydan, AS	1
Bianciotti, LG; di Nunzio, A; Hope, SI; Legaz, G; Morgazo, C; Perfume, G; Vatta, MS	1
Cheng, JT; Liao, CH; Teng, CM	1
Chang, YL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Lin, CH; Liu, YN; Pai, HC; Pan, SL; Peng, CY; Teng, CM	1
Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T	1
Bagcivan, I; Duman, M; Karadas, B; Kaya, T; Sarac, B; Turan, M	1
Chalimoniuk, M; Langfort, J; Lukacova, N; Marsala, J	1
Abdallah, Y; Euler, G; Piper, HM; Schlüter, KD; Tastan, H	1
Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF	1
Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM	1
Hattori, T; Kanatsuka, H; Koshida, R; Nagaoka, M; Nara, M; Tamada, T; Tamura, G	1
Fu, WM; Lin, CJ; Liou, HC; Lu, DY; Yeh, WL	1
Bilodeau, ML; Hamm, HE	1
Dhir, A; Kulkarni, SK	2
da-Silva, CA; Del Bel, EA; Echeverry, MB; Ferreira, FR; Salgado, ML	1
Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J	1
Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S	1
Del Bel, EA; Echeverry, MB; Guimarães, FS; Iyomasa, M; Spolidório, PC	1
Huang, CT; Liao, CH; Lin, CY; Lin, YC; Tsai, IF; Yang, CM	1
Green, AK; Squires, PE; Stratton, RC	1
Garthwaite, J; Halvey, EJ; Roy, B	1
Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P	1
Acierno, R; Amelio, D; Gattuso, A; Guerrieri, A; Mannarino, C; Tota, B	1
Chien, WL; Fu, WM; Liang, KC	1
Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ	1
Brocardo, Pde S; Budni, J; Kaster, MP; Lobato, KR; Rodrigues, AL	1
Dismuke, WM; Ellis, DZ; Sharif, NA	1
Aydin, C; Bagcivan, I; Koyuncu, A; Ozer, H; Soylu, S; Topcu, O; Yildirim, S	1
Durante, W; Keswani, AN; Peyton, KJ; Schafer, AI; Tulis, DA	1
Kohr, MJ; Traynham, CJ; Wang, H; Ziolo, MT	1
Chang, CS; Chang, LC; Huang, LJ; Kuo, SC; Lin, RH; Wang, JP	1
Calixto, AV; De Lima, TC; Duarte, FS; Duzzioni, M; Faria, MS; Nascimento Häckl, LP	1
Choi, I; Jeong, M; Kang, YH; Kim, MJ; Kim, MS; Kim, TD; Lee, SH; Myung, PK; Piao, ZH; Suh, HW; Yoon, SR; Yun, S	1
Bicker, G; Böger, N; Eickhoff, R; Holstein, GR; Kerssen, U; Lorbeer, C; Martinelli, GP; Stern, M; Ziegler, M	1
Bahremand, A; Dehpour, AR; Hedayat, T; Nasrabady, SE; Payandemehr, B; Rahimian, R; Ziai, P	1
Cosgrave, AS; McKay, JS; Thippeswamy, T	1
Hung, CC; Liou, HH	1
Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z	1
Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E	1
Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS	1
Balen, Gde O; Budni, J; Fernandes, SC; Freitas, AE; Moretti, M; Rodrigues, AL	1
Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R	1
Aricioglu, F; Utkan, T; Yazir, Y	1
Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH	1
Dehpour, AR; Ejtemaei Mehr, S; Hassanzadeh, G; Khan, MI; Ostadhadi, S; Zolfaghari, S	1
Chang, SF; Fong, TH; Huang, HP; Tsui, L; Wang, IJ	1
Liao, ZL; Qiu, YJ; Tan, YF; Yu, EY; Zhu, JP	1
Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M	1
Biala, G; Jakobczuk, M; Kotlinska, J; Listos, J; Orzelska-Gorka, J; Talarek, S	1
Chamanara, M; Dehpour, AR; Nikoui, V; Norouzi-Javidan, A; Ostadhadi, S; Shakiba, S; Zolfaghari, S	1
Koizumi, K; Nabeta, R; Nakamura, Y; Oka, JI; Sasaki-Hamada, S	1

Reviews

3 review(s) available for indazoles and cyclic gmp

Article	Year
Nitric oxide signaling in brain: potentiating the gain with YC-1. Molecular pharmacology, 2003, Volume: 63, Issue:6 Topics: Animals; Brain; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide; Signal Transduction	2003
Versatile pharmacological actions of YC-1: anti-platelet to anticancer. Cancer letters, 2004, Apr-15, Volume: 207, Issue:1 Topics: Animals; Antineoplastic Agents; Cyclic GMP; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neoplasms; Platelet Aggregation Inhibitors; Transcription Factors	2004
Salutary properties of YC-1 in the cardiovascular and hematological systems. Current medicinal chemistry. Cardiovascular and hematological agents, 2004, Volume: 2, Issue:4 Topics: Animals; Blood; Cardiovascular System; Cyclic GMP; Enzyme Activators; Humans; Indazoles; Nitric Oxide; Platelet Aggregation Inhibitors	2004

Other Studies

143 other study(ies) available for indazoles and cyclic gmp

Article	Year
YC-1, a novel activator of platelet guanylate cyclase. Blood, 1994, Dec-15, Volume: 84, Issue:12 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alprostadil; Animals; Bleeding Time; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Methemoglobin; Mice; Molecular Structure; Nitroprusside; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Superoxide Dismutase; Thromboxane A2	1994
Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism. Circulation research, 1995, Volume: 76, Issue:3 Topics: Animals; Arginine; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Indazoles; Inflammation; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P	1995
Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells. The Biochemical journal, 1995, Mar-15, Volume: 306 ( Pt 3) Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Cyclic GMP; Flow Cytometry; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rats	1995
Regulation of bradykinin sensitivity in peripheral sensory fibres of the neonatal rat by nitric oxide and cyclic GMP. Neuropharmacology, 1994, Volume: 33, Issue:10 Topics: Animals; Animals, Newborn; Arginine; Bradykinin; Concanavalin A; Cyclic GMP; Indazoles; Methylene Blue; Nitric Oxide; Nitroprusside; Nociceptors; Rats; Receptors, Bradykinin; Spinal Cord	1994
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Guanylate Cyclase; Hemoglobins; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phthalazines; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Solubility; Thrombin; Thromboxane A2; Vasoconstrictor Agents	1995
Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3 Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Harmaline; Hydroxydopamines; Indazoles; Lisuride; Locomotion; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures	1996
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators. British journal of pharmacology, 1997, Volume: 120, Issue:4 Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Rabbits; Rats; Rats, Inbred WKY; Superoxides; Vasodilator Agents	1997
Inhibition of platelet adhesion to collagen by cGMP-elevating agents. Biochemical and biophysical research communications, 1997, Feb-13, Volume: 231, Issue:2 Topics: Actins; Adult; Blood Platelets; Calcium; Collagen; Cyclic GMP; Humans; Indazoles; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors	1997
Obligatory role of NO in glutamate-dependent hyperemia evoked from cerebellar parallel fibers. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2 Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Glutamic Acid; Hyperemia; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxygen; Papaverine; Partial Pressure; Penicillamine; Rats; Rats, Sprague-Dawley; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Vasodilation	1997
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. The Journal of clinical investigation, 1997, Jul-15, Volume: 100, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Indazoles; Kidney; Losartan; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Sodium; Tetrazoles	1997
nNOS and Ca2+ influx in rat pancreatic acinar and submandibular salivary gland cells. Cell calcium, 1997, Volume: 22, Issue:3 Topics: Animals; Blotting, Western; Bombesin; Calcium; Cells, Cultured; Cholecystokinin; Cyclic GMP; Immunohistochemistry; Indazoles; Nitric Oxide Synthase; Pancreatic Ducts; Rats; Signal Transduction; Submandibular Gland	1997
Role of neuronal NO synthase in relationship between NO and opioids in hypoxia-induced pial artery dilation. The American journal of physiology, 1997, Volume: 273, Issue:4 Topics: Animals; Cerebral Arteries; Cyclic GMP; Endorphins; Enkephalins; Enzyme Inhibitors; Female; Hypoxia; Indazoles; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase; Pia Mater; Swine; Tetrodotoxin; Vasodilation	1997
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Adrenergic beta-Agonists; Animals; Calcium; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Indazoles; Isoproterenol; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vasoconstriction	1997
Possible role of nitric oxide-cyclic GMP pathway in object recognition memory: effects of 7-nitroindazole and zaprinast. European journal of pharmacology, 1997, Oct-22, Volume: 337, Issue:2-3 Topics: Animals; Blood Pressure; Cyclic GMP; Drug Interactions; Exploratory Behavior; Indazoles; Male; Memory; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Purinones; Rats; Signal Transduction; Visual Perception	1997
Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice. The American journal of physiology, 1998, Volume: 274, Issue:2 Topics: Acetylcholine; Animals; Arginine; Arterioles; Autoradiography; Brain; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Indazoles; Mice; Mice, Knockout; Neurons; Nitric Oxide Synthase; Pia Mater; Quinuclidinyl Benzilate; Receptors, Muscarinic; Vasodilation	1998
A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity. British journal of pharmacology, 1998, Volume: 123, Issue:6 Topics: Animals; Carrageenan; Cyclic GMP; Edema; Enzyme Inhibitors; Hindlimb; Indazoles; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar	1998
Calcium-dependent and ATP-sensitive potassium channels and the 'permissive' function of cyclic GMP in hypercapnia-induced pial arteriolar relaxation. Brain research, 1998, May-18, Volume: 793, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Blood Pressure; Calcium; Carbon Dioxide; Cerebral Arteries; Cromakalim; Cyclic GMP; Glyburide; Hydrogen-Ion Concentration; Hypercapnia; Indazoles; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Penicillamine; Peptides; Pia Mater; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Substrate Specificity; Vasodilation	1998
Lack of correlation between the reduction of sevoflurane MAC and the cerebellar cyclic GMP concentrations in mice treated with 7-nitroindazole. Anesthesiology, 1998, Volume: 89, Issue:1 Topics: Anesthetics, Inhalation; Animals; Cerebellum; Cyclic GMP; Enzyme Inhibitors; Indazoles; Lung; Methyl Ethers; Mice; Nitric Oxide Synthase; Sevoflurane	1998
Nitric oxide regulates cyclic GMP-dependent protein kinase phosphorylation in rat brain. Journal of neurochemistry, 1998, Volume: 71, Issue:2 Topics: Animals; Arousal; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; GABA Modulators; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Pentobarbital; Phosphorylation; Rats; Rats, Wistar; Thalamus	1998
Human soluble guanylate cyclase: functional expression and revised isoenzyme family. The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1) Topics: Amino Acid Sequence; Animals; Cattle; Cyclic GMP; Guanosine Triphosphate; Guanylate Cyclase; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Protein Conformation; Rats; Recombinant Proteins; Solubility; Spodoptera; Vasodilator Agents	1998
NMDA receptor-dependent nitric oxide and cGMP synthesis in brain hemispheres and cerebellum during reperfusion after transient forebrain ischemia in gerbils: effect of 7-Nitroindazole. Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5 Topics: Animals; Brain Ischemia; Cerebellum; Cerebral Cortex; Cyclic GMP; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gerbillinae; Indazoles; Lipid Peroxidation; Male; Membrane Lipids; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Signal Transduction; Thiobarbituric Acid Reactive Substances	1998
YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets. Molecular pharmacology, 1998, Volume: 54, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Vasodilator Agents	1998
Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations. Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2 Topics: Ammonia; Animals; Biomarkers; Cells, Cultured; Chronic Disease; Cyclic GMP; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Indazoles; Lymphocytes; Neurons; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Time Factors	1999
Sevoflurane MAC and cerebellar cyclic GMP. Anesthesiology, 1999, Volume: 90, Issue:5 Topics: Anesthetics, Inhalation; Cerebellum; Cyclic GMP; Humans; Indazoles; Methyl Ethers; Pulmonary Alveoli; Sevoflurane	1999
The parafascicular thalamic nucleus but not the prefrontal cortex facilitates the nitric oxide/cyclic GMP pathway in rat striatum. Neuroscience, 1999, Volume: 91, Issue:1 Topics: Animals; Cyclic GMP; Electric Stimulation; Electrodes, Implanted; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Indazoles; Male; Microdialysis; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Prefrontal Cortex; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Thalamic Nuclei	1999
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity. British journal of pharmacology, 1999, Volume: 127, Issue:1 Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents	1999
Miconazole represses CO(2)-induced pial arteriolar dilation only under selected circumstances. The American journal of physiology, 1999, Volume: 277, Issue:4 Topics: Animals; Arterioles; Carbon Dioxide; Cyclic GMP; Drug Combinations; Enzyme Inhibitors; Hypercapnia; Indazoles; Miconazole; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pia Mater; Potassium Channels; Rats; Rats, Sprague-Dawley; Reference Values; Vasodilation	1999
YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. British journal of pharmacology, 1999, Volume: 128, Issue:3 Topics: Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Nitric Oxide; Superoxides; Trachea	1999
YC-1 potentiates the antiplatelet effect of hydrogen peroxide via sensitization of soluble guanylate cyclase. European journal of pharmacology, 1999, Sep-24, Volume: 381, Issue:2-3 Topics: Antioxidants; Blood Platelets; Catalase; Cyclic GMP; Glucose Oxidase; Glutathione Peroxidase; Guanylate Cyclase; Hemostatics; Humans; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Mannitol; Platelet Aggregation Inhibitors; Superoxide Dismutase; Thrombin	1999
Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. British journal of pharmacology, 1999, Volume: 128, Issue:5 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Homeostasis; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Purinones; Spermine	1999
A point-mutated guanylyl cyclase with features of the YC-1-stimulated enzyme: implications for the YC-1 binding site? Biochemistry, 1999, Nov-16, Volume: 38, Issue:46 Topics: Animals; Binding Sites; Catalytic Domain; Cattle; Conserved Sequence; Cyclic GMP; Dimerization; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Magnesium; Manganese; Mutagenesis, Site-Directed; Nitric Oxide; Point Mutation; Solubility	1999
Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase. British journal of pharmacology, 1999, Volume: 128, Issue:6 Topics: Animals; Aorta, Thoracic; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Ionophores; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Rats; Rats, Wistar; Solubility; Time Factors	1999
Novel strategies for opposing murine microglial activation. Neuroscience letters, 2000, Jan-07, Volume: 278, Issue:1-2 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dipyridamole; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Imidazoles; Indazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha	2000
Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Neuropharmacology, 2000, Volume: 39, Issue:12 Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Brain Chemistry; Cyclic GMP; Enzyme Inhibitors; Guanidines; Indazoles; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma	2000
Nitric oxide and cGMP influence axonogenesis of antennal pioneer neurons. Development (Cambridge, England), 2000, Volume: 127, Issue:21 Topics: Animals; Axonal Transport; Axons; Cyclic GMP; Dihydrolipoamide Dehydrogenase; Embryo, Nonmammalian; Enzyme Inhibitors; Grasshoppers; Guanylate Cyclase; Horseradish Peroxidase; Indazoles; Morphogenesis; Nervous System; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction	2000
Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia. British journal of pharmacology, 2000, Volume: 131, Issue:5 Topics: Animals; Brain Chemistry; Cricetinae; Cyclic GMP; Dopamine; Dystonia; Enzyme Inhibitors; Indazoles; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Receptors, N-Methyl-D-Aspartate	2000
Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis. American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:6 Topics: Animals; Arginine Vasopressin; Ascites; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Hemodynamics; Indazoles; Kidney; Kidney Function Tests; Liver Cirrhosis, Experimental; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sodium; Vasodilation	2000
YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formation. Biochemical and biophysical research communications, 2000, Dec-20, Volume: 279, Issue:2 Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cyclic GMP; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Recurrence; RNA, Messenger; Transcription, Genetic; Tunica Intima	2000
Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells. Molecular pharmacology, 2001, Volume: 59, Issue:2 Topics: Animals; Cells, Cultured; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Swine	2001
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate. Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:1 Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rabbits; Vasodilator Agents	2001
Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells. Biochemical pharmacology, 2001, Apr-01, Volume: 61, Issue:7 Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Drug Interactions; Electrophysiology; Enzyme Activators; Indazoles; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; PC12 Cells; Pheochromocytoma; Pituitary Gland; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; Tumor Cells, Cultured; Vinca Alkaloids	2001
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochemical pharmacology, 2001, Apr-15, Volume: 61, Issue:8 Topics: Cell Hypoxia; Cyclic GMP; DNA-Binding Proteins; Drug Interactions; Endothelial Growth Factors; Enzyme Activators; Erythropoietin; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lymphokines; Nuclear Proteins; Oxygen; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein. Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin	2001
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis. Neuroscience, 2001, Volume: 104, Issue:4 Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission	2001
Inhibition of neuronal nitric oxide synthase ameliorates renal hyperfiltration in streptozotocin-induced diabetic rat. The Journal of laboratory and clinical medicine, 2001, Volume: 138, Issue:3 Topics: Animals; Cyclic GMP; Diabetes Mellitus, Experimental; Drug Synergism; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Indazoles; Infusions, Intravenous; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Rats; Rats, Sprague-Dawley; Renal Plasma Flow; Vascular Resistance	2001
Inhibition of glucose transport by cyclic GMP in cardiomyocytes. Life sciences, 2001, Aug-10, Volume: 69, Issue:12 Topics: Animals; Biological Transport; Cell Hypoxia; Cell Membrane Permeability; Cells, Cultured; Cyclic GMP; Deoxyglucose; Drug Combinations; Female; Glucose Transporter Type 4; Glycolysis; Hydrogen Peroxide; Indazoles; Insulin; Microscopy, Confocal; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oligomycins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Rotenone	2001
Inhibition of extracellular Ca(2+) entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils. Biochemical pharmacology, 2001, Sep-15, Volume: 62, Issue:6 Topics: Animals; Calcium; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Ion Transport; Manganese; Neutrophils; Phosphorylation; Platelet Aggregation Inhibitors; Rats; Solubility; Tyrosine	2001
The nNOS/cGMP signal transducing system is involved in the cardiovascular responses induced by activation of NMDA receptors in the rostral ventrolateral medulla of cats. Neuroscience letters, 2001, Sep-14, Volume: 310, Issue:2-3 Topics: Animals; Blood Pressure; Bradycardia; Cats; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; Heart Rate; Hypertension; Indazoles; Male; Medulla Oblongata; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Signal Transduction	2001
Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism. Neuropharmacology, 2001, Volume: 41, Issue:7 Topics: Adrenal Medulla; Animals; Apoptosis; Cattle; Cell Adhesion; Cell Size; Cells, Cultured; Chromaffin Cells; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium; Enzyme Activators; Indazoles; Intracellular Fluid; Time Factors	2001
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition. Molecular pharmacology, 2002, Volume: 61, Issue:1 Topics: Animals; Axons; Cyclic GMP; Drug Interactions; Enzyme Activators; Glucose; Guanylate Cyclase; Indazoles; Male; Nitric Oxide; Oxygen; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels	2002
Compensatory role of NO in cerebral circulation of piglets chronically treated with indomethacin. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:2 Topics: Acetylcholine; Animals; Animals, Newborn; Bradykinin; Cardiovascular Agents; Cells, Cultured; Cerebrovascular Circulation; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypercapnia; Indazoles; Indomethacin; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pia Mater; Swine; Vasodilator Agents	2002
Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:1 Topics: Animals; Arginine; Cyclic GMP; Female; Indazoles; Intraocular Pressure; Male; Nitric Oxide Donors; Nitric Oxide Synthase; Purinones; Rabbits	2002
YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. Biochemical and biophysical research communications, 2002, Mar-08, Volume: 291, Issue:4 Topics: Angioplasty, Balloon; Animals; Arterial Occlusive Diseases; Blood Platelets; Carotid Stenosis; Cell Adhesion; Cell Division; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Hydrogels; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Polyethylene Glycols; Rats; Rats, Sprague-Dawley	2002
Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle. American journal of hypertension, 2002, Volume: 15, Issue:3 Topics: Animals; Cells, Cultured; Cyclic GMP; Dogs; Guanylate Cyclase; Indazoles; Insulin; Isocitrates; Lactic Acid; Muscle, Smooth, Vascular; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxaloacetic Acid; Oxidation-Reduction; Pyruvic Acid; Stimulation, Chemical	2002
Facilitatory role of NO in neural norepinephrine release in the rat kidney. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:5 Topics: Animals; Benzoates; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indazoles; Kidney; Male; Nervous System; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Oxazines; Perfusion; Pressure; Rats; Rats, Wistar	2002
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1. International journal of impotence research, 2002, Volume: 14, Issue:2 Topics: Animals; Cell Line; Cloning, Molecular; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Isoenzymes; Male; Muscle, Smooth; Nitric Oxide; Penis; Rabbits; Rats; Recombinant Proteins	2002
Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic GMP-dependent and -independent mechanisms. Biochemical pharmacology, 2002, Feb-15, Volume: 63, Issue:4 Topics: Animals; Calcium; Cell-Free System; Cyclic GMP; Enzyme Activators; In Vitro Techniques; Indazoles; Mitogen-Activated Protein Kinases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphorylation; Protein Kinase C; Rats; Respiratory Burst; Superoxides	2002
Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed. British journal of pharmacology, 2002, Volume: 137, Issue:1 Topics: Animals; Arginine; Bucladesine; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic GMP; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; Indazoles; Male; Mesenteric Arteries; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2002
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats. Behavioural brain research, 2002, Aug-21, Volume: 134, Issue:1-2 Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Cyclic GMP; Depression; Dimethyl Sulfoxide; Enzyme Inhibitors; Guanylate Cyclase; Imipramine; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Swimming	2002
Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:3 Topics: Animals; Blood Pressure; Culture Techniques; Cyclic GMP; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hypertension; Indazoles; Male; Mesenteric Arteries; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents	2002
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction	2002
A-350619: a novel activator of soluble guanylyl cyclase. Life sciences, 2003, Jan-17, Volume: 72, Issue:9 Topics: Acrylamides; Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Penile Erection; Rabbits; Rats; Rats, Wistar; Spodoptera	2003
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats. European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2 Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents	2003
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle. European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3 Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Indazoles; Isoindoles; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Organoselenium Compounds; Papaverine; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Vasodilation	2003
Effect of the neuronal nitric oxide synthase inhibitor 7-nitroindazole on the righting reflex ED50 and minimum alveolar concentration during sevoflurane anaesthesia in rats. European journal of anaesthesiology, 2003, Volume: 20, Issue:3 Topics: Anesthetics, Inhalation; Animals; Blood Gas Analysis; Brain; Cerebellum; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Indazoles; Male; Methyl Ethers; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Postural Balance; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Sevoflurane; Spinal Cord	2003
The effect of L-arginine on slow motility of mammalian outer hair cell. Hearing research, 2003, Volume: 178, Issue:1-2 Topics: Animals; Arginine; Calcium; Cell Membrane Permeability; Cell Movement; Cell Size; Cyclic GMP; Enzyme Inhibitors; Extracellular Fluid; Guinea Pigs; Hair Cells, Auditory, Outer; Indazoles; Intracellular Membranes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Osmolar Concentration	2003
Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochemical pharmacology, 2003, Jul-01, Volume: 66, Issue:1 Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Macrophages, Alveolar; Rats; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha	2003
YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway. Biochemical pharmacology, 2003, Jul-15, Volume: 66, Issue:2 Topics: Cell Division; Cyclic GMP; DNA; Endothelium, Vascular; G1 Phase; Humans; Indazoles; Platelet Aggregation Inhibitors; Resting Phase, Cell Cycle; Thymidine; Tritium	2003
Cardiac enkephalins attenuate vagal bradycardia: interactions with NOS-1-cGMP systems in canine sinoatrial node. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Bradycardia; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enzyme Inhibitors; Indazoles; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parasympathomimetics; Penicillamine; Phosphodiesterase Inhibitors; Sinoatrial Node; Vagus Nerve	2003
Preparation of heme-free soluble guanylate cyclase. Protein expression and purification, 2003, Volume: 31, Issue:1 Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc	2003
Arachidonic acid regulates two Ca2+ entry pathways via nitric oxide. Cellular signalling, 2004, Volume: 16, Issue:2 Topics: Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Fura-2; Gadolinium; Indazoles; Mice; Nitric Oxide; Parotid Gland; Ryanodine; Tetracaine; Thapsigargin; Triazoles	2004
Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Molecular pharmacology, 2003, Volume: 64, Issue:6 Topics: Adolescent; Adult; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Humans; Indazoles; Neutrophils; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Superoxides	2003
Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat. Neuropharmacology, 2004, Volume: 46, Issue:1 Topics: Aminoquinolines; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Feedback; Hippocampus; Indazoles; Male; Microinjections; Nitric Oxide; Penile Erection; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Venous Pressure	2004
The NO signaling pathway differentially regulates KCC3a and KCC3b mRNA expression. Nitric oxide : biology and chemistry, 2003, Volume: 9, Issue:3 Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Soluble Guanylyl Cyclase; Symporters; Thionucleotides	2003
Neuronal nitric oxide synthase and N-methyl-D-aspartate neurons in experimental carbon monoxide poisoning. Toxicology and applied pharmacology, 2004, Feb-01, Volume: 194, Issue:3 Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Carbon Monoxide Poisoning; Cyclic GMP; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Laser-Doppler Flowmetry; Male; Maze Learning; Mice; Mice, Knockout; Microelectrodes; Neurons; Neurotoxicity Syndromes; Neutropenia; Neutrophils; NG-Nitroarginine Methyl Ester; Nimodipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Platelet Count; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tyrosine	2004
Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS letters, 2004, Feb-13, Volume: 559, Issue:1-3 Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinase Type II; Cyclic GMP-Dependent Protein Kinases; Dactinomycin; Guanylate Cyclase; Indazoles; Insulin; Insulin Secretion; Islets of Langerhans; Protein Isoforms; Rats; Signal Transduction; Thionucleotides; Transcription, Genetic	2004
Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site? Biochemistry, 2004, Mar-23, Volume: 43, Issue:11 Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; COS Cells; Cyclic GMP; Cysteine; Cytosol; DNA Mutational Analysis; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Kinetics; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide; Phenotype; Protein Subunits; Pyrazoles; Pyridines; Rats; Solubility; Tyrosine	2004
Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272. Circulation, 2004, Apr-13, Volume: 109, Issue:14 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Humans; Indazoles; Kidney; Nitric Oxide; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Quaternary Ammonium Compounds; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; S-Nitrosoglutathione; Soluble Guanylyl Cyclase; Transfection; Vasodilation	2004
cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:6 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arterioles; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activators; Hydrolysis; Indazoles; Male; Multidrug Resistance-Associated Proteins; Nitric Oxide; Nitric Oxide Donors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Vasodilation	2004
Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland. Archives of oral biology, 2004, Volume: 49, Issue:9 Topics: Amylases; Animals; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Muscarinic Agonists; Nitric Oxide; Nitric Oxide Donors; Parotid Gland; Rats; Rats, Wistar; S-Nitrosoglutathione; Signal Transduction	2004
YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells. Molecular pharmacology, 2004, Volume: 66, Issue:3 Topics: Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; I-kappa B Proteins; Indazoles; Interleukin-1; Isoenzymes; Lung; Membrane Proteins; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Polyenes; Polyunsaturated Alkamides; Proline; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Thiocarbamates; Transcription Factors	2004
An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain. The European journal of neuroscience, 2004, Volume: 20, Issue:5 Topics: Amino Acid Sequence; Animals; Brain; Conserved Sequence; Cyclic GMP; Evolution, Molecular; Female; Grasshoppers; Guanylate Cyclase; Indazoles; Insect Proteins; Male; Molecular Sequence Data; Nitric Oxide; Periplaneta; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Up-Regulation	2004
Soluble guanylyl cyclase during postnatal porcine pulmonary maturation. American journal of physiology. Lung cellular and molecular physiology, 2005, Volume: 288, Issue:1 Topics: Aging; Animals; Animals, Newborn; Base Sequence; Cyclic GMP; Enzyme Activators; Guanylate Cyclase; Indazoles; Molecular Sequence Data; Nitric Oxide; Pulmonary Artery; RNA, Messenger; Sequence Homology, Nucleic Acid; Solubility; Swine; Vasodilation	2005
Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic AMP accumulation from cultured rat granulosa cells. Fertility and sterility, 2004, Volume: 82 Suppl 3 Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Synergism; Enzyme Activation; Enzyme Activators; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Guanylate Cyclase; Hormones; Immunoblotting; Indazoles; Isoenzymes; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Solubility	2004
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Cyclic GMP; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; G1 Phase; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; Transcription Factors; Tumor Suppressor Proteins	2005
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1 Topics: Acetylcholine; Animals; beta-Cyclodextrins; Caveolae; Caveolin 1; Caveolins; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Immunohistochemistry; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents	2005
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Biology of reproduction, 2005, Volume: 73, Issue:3 Topics: Adherens Junctions; Animals; beta Catenin; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeletal Proteins; Gene Expression Regulation; Hydrazines; Indazoles; Indoles; Male; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Signal Transduction; Spermatozoa; Trans-Activators	2005
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models. Thrombosis and haemostasis, 2005, Volume: 93, Issue:5 Topics: Animals; Blotting, Western; Cyclic GMP; Cytokines; Disease Models, Animal; DNA; Endotoxemia; Humans; Immunohistochemistry; Indazoles; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Shock, Septic; Time Factors; Up-Regulation	2005
Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma. Human psychopharmacology, 2005, Volume: 20, Issue:5 Topics: Animals; Cyclic GMP; Disease Models, Animal; Hippocampus; Indazoles; Male; NF-kappa B; Nitric Oxide; Piperazines; Proline; Purines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sildenafil Citrate; Stress Disorders, Post-Traumatic; Sulfones; Thiocarbamates	2005
Nitric oxide/cyclic guanosine monophosphate signaling in the central complex of the grasshopper brain inhibits singing behavior. The Journal of comparative neurology, 2005, Jul-25, Volume: 488, Issue:2 Topics: Animals; Behavior, Animal; Brain; Cyclic GMP; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Functional Laterality; Grasshoppers; Immunohistochemistry; Indazoles; Male; Muscarine; Muscarinic Agonists; Muscle, Smooth, Vascular; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Signal Transduction; Time Factors; Vocalization, Animal	2005
YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor. European journal of pharmacology, 2005, Jul-04, Volume: 517, Issue:1-2 Topics: Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; Gene Expression; Glomerular Mesangium; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanylate Cyclase; Imidazoles; Indazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Rats; RNA, Messenger; Signal Transduction; Solubility; Tumor Suppressor Proteins	2005
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium. European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3 Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indazoles; Male; Methylene Blue; Muscle Relaxation; Myometrium; Nitric Oxide Donors; Pregnancy; Rats; Rats, Wistar; Time Factors; Triazenes; Uterine Contraction	2005
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus. Biochemical and biophysical research communications, 2005, Sep-02, Volume: 334, Issue:3 Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase	2005
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction. European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2 Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors	2005
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Carotid Arteries; Catheterization; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Immunohistochemistry; Indazoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2006
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3 Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents	2006
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2006, Volume: 6, Issue:3 Topics: Animals; Cyclic GMP; Hydrazines; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Neuromuscular Blocking Agents; Nitrogen Oxides; Sheep; Sphincter of Oddi	2006
Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neuroscience, 2006, Aug-25, Volume: 141, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Count; Cyclic GMP; Disease Models, Animal; Drug Administration Schedule; Gene Expression Regulation; Guanylate Cyclase; Immunohistochemistry; Indazoles; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinsonian Disorders; Time Factors; Tyrosine 3-Monooxygenase	2006
Contractile performance of adult ventricular rat cardiomyocytes is not directly jeopardized by NO/cGMP-dependent induction of pro-apoptotic pathways. Journal of molecular and cellular cardiology, 2007, Volume: 42, Issue:2 Topics: Animals; Apoptosis; Caspase 3; Cell Movement; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Indazoles; Male; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction	2007
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction? Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4 Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines	2007
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia. British journal of pharmacology, 2007, Volume: 151, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides	2007
A potentiating effect of endogenous NO in the physiologic secretion from airway submucosal glands. American journal of respiratory cell and molecular biology, 2007, Volume: 37, Issue:3 Topics: Acetylcholine; Animals; Calcium Signaling; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Exocrine Glands; In Vitro Techniques; Indazoles; Indoles; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Sus scrofa; Trachea	2007
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression. Molecular pharmacology, 2007, Volume: 72, Issue:2 Topics: Animals; Blood-Brain Barrier; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ischemia; Male; Membrane Proteins; Permeability; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein	2007
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Bucladesine; Calcium; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Microfilament Proteins; Nucleotides, Cyclic; Oligopeptides; Peptide Fragments; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thionucleotides; Thrombin	2007
Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2 Topics: Animals; Antidepressive Agents; Arginine; Behavior, Animal; Berberine; Brain Chemistry; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Hindlimb Suspension; Indazoles; Injections, Intraperitoneal; Male; Mice; Motor Activity; Neurotransmitter Agents; Nitric Oxide; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Stress, Psychological; Sulfones; Swimming; Time Factors	2007
Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice. Psychopharmacology, 2007, Volume: 194, Issue:2 Topics: Animals; Arginine; Behavior, Animal; Catalepsy; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Injections, Intraventricular; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors	2007
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovascular research, 2007, Oct-01, Volume: 76, Issue:1 Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents	2007
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft. Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5 Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation	2007
Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus. Psychopharmacology, 2007, Volume: 195, Issue:2 Topics: Analysis of Variance; Animals; Anxiety; Cyclic GMP; Dentate Gyrus; Dose-Response Relationship, Drug; Guanylate Cyclase; Hippocampus; Indazoles; Male; Maze Learning; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Punishment; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase	2007
Modulation of human monocyte-derived dendritic cells maturation by a soluble guanylate cyclase activator, YC-1, in a cyclic nucleotide independent manner. International immunopharmacology, 2007, Volume: 7, Issue:10 Topics: Cell Differentiation; Cell Proliferation; Cyclic AMP; Cyclic GMP; Dendritic Cells; Guanylate Cyclase; Humans; Immunologic Factors; Indazoles; Interleukin-10; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Receptors, CCR7; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; T-Lymphocytes	2007
ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha. Biochemical and biophysical research communications, 2008, Apr-18, Volume: 368, Issue:4 Topics: Animals; Atrial Natriuretic Factor; Calcium; Cell Membrane; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Hepatocytes; Indazoles; Male; Nitroprusside; Rats; Rats, Wistar; Thionucleotides	2008
An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase. The Journal of biological chemistry, 2008, Jul-04, Volume: 283, Issue:27 Topics: Adenosine Triphosphate; Adenylyl Cyclases; Allosteric Regulation; Animals; Cattle; Cyclic GMP; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Kinetics; Lung; Models, Chemical; Nitric Oxide; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrophosphatases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Thermodynamics	2008
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:5 Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase	2008
Nitric oxide modulates the frog heart ventricle morphodynamics. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2008, Volume: 151, Issue:1 Topics: Animals; Anura; Arginine; Cyclic GMP; Female; Heart Ventricles; In Vitro Techniques; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Perfusion; Serine; Software; Ventricular Function	2008
Enhancement of active shuttle avoidance response by the NO-cGMP-PKG activator YC-1. European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3 Topics: Amygdala; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Indazoles; Long-Term Potentiation; Male; MAP Kinase Signaling System; Nitric Oxide; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger	2008
Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the "antinociceptive-like effects" of diazepam. Pharmacology, biochemistry, and behavior, 2008, Volume: 91, Issue:1 Topics: Analgesics; Animals; Arginine; Cyclic GMP; Diazepam; Enzyme Inhibitors; Guanylate Cyclase; Hypnotics and Sedatives; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Pain Measurement; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction	2008
Antidepressant-like effect of folic acid: Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway. European journal of pharmacology, 2008, Nov-19, Volume: 598, Issue:1-3 Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Folic Acid; Indazoles; Injections, Intraventricular; Male; Methylene Blue; Mice; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Swimming; Vitamin B Complex	2008
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork	2009
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2009, Volume: 42, Issue:3 Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazines; In Vitro Techniques; Indazoles; Ligation; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Papaverine; Piperazines; Purines; Sildenafil Citrate; Sulfones	2009
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:2 Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Proliferation; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley	2009
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. Journal of molecular and cellular cardiology, 2009, Volume: 47, Issue:2 Topics: Animals; Calcium Channels, L-Type; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Indazoles; Ion Channel Gating; Isoproterenol; Mice; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Purinones; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase	2009
Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils. European journal of pharmacology, 2009, Aug-01, Volume: 615, Issue:1-3 Topics: Animals; Cell-Free System; Cyclic AMP; Cyclic GMP; Indazoles; NADPH Oxidases; Neutrophils; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides	2009
Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. Behavioural brain research, 2010, Feb-11, Volume: 207, Issue:1 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Exploratory Behavior; Hippocampus; Indazoles; Male; Methylene Blue; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Staining and Labeling	2010
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells. International immunopharmacology, 2010, Volume: 10, Issue:4 Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Fetal Blood; Flow Cytometry; Hematopoietic Stem Cells; Humans; Imidazoles; Indazoles; Killer Cells, Natural; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-15; Signal Transduction; STAT5 Transcription Factor	2010
Development of nitrergic neurons in the nervous system of the locust embryo. The Journal of comparative neurology, 2010, Apr-15, Volume: 518, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Citrulline; Cyclic GMP; Embryo, Nonmammalian; Enzyme Activators; Ganglia, Invertebrate; Indazoles; Locusta migratoria; NADPH Dehydrogenase; Nerve Regeneration; Nervous System; Neurites; Neurons; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Signal Transduction	2010
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice. Epilepsy research, 2010, Volume: 89, Issue:2-3 Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Injections, Intraperitoneal; Lithium Chloride; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Sildenafil Citrate; Sulfones; Treatment Outcome	2010
Differential regulation of vasoactive intestinal peptide (VIP) in the dentate gyrus and hippocampus via the NO-cGMP pathway following kainic acid-induced seizure in the rat. Journal of molecular neuroscience : MN, 2010, Volume: 42, Issue:3 Topics: Animals; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Indazoles; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide	2010
YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway. Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Humans; Indazoles; Nitric Oxide; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; Signal Transduction	2011
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cellular and molecular neurobiology, 2011, Volume: 31, Issue:2 Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling	2011
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine. Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:2 Topics: Analgesics, Opioid; Animals; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; Indazoles; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Soluble Guanylyl Cyclase	2011
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3 Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic	2011
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test. Behavioural brain research, 2011, Nov-20, Volume: 225, Issue:1 Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones	2011
Antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a putative trace amine receptor ligand involves l-arginine-nitric oxide-cyclic guanosine monophosphate pathway. Neuroscience letters, 2011, Oct-03, Volume: 503, Issue:2 Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Biogenic Amines; Brain Chemistry; Cyclic GMP; Cyclohexanols; Depression; Guanylate Cyclase; Indazoles; Isoquinolines; Male; Methylene Blue; Mice; Motor Activity; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones; Swimming	2011
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction. Postepy higieny i medycyny doswiadczalnej (Online), 2011, Aug-05, Volume: 65 Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea	2011
Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress. Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:3 Topics: Animals; Antidepressive Agents; Cyclic GMP; Depression; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Indazoles; Male; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Stress, Psychological; Swimming	2012
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:10 Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Female; Fetal Growth Retardation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Proteinuria; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Suramin; Vasodilation; Vasodilator Agents	2013
The involvement of NMDA receptor/NO/cGMP pathway in the antidepressant like effects of baclofen in mouse force swimming test. Neuroscience letters, 2016, Jan-26, Volume: 612 Topics: Animals; Antidepressive Agents; Arginine; Baclofen; Cyclic GMP; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sildenafil Citrate; Stress, Psychological; Swimming	2016
YC-1 induces lipid droplet formation in RAW 264.7 macrophages. Journal of biomedical science, 2016, Jan-15, Volume: 23 Topics: Animals; Cell Line; Cyclic GMP; Indazoles; Lipid Droplets; Lipoproteins, LDL; Macrophages; Mice; Second Messenger Systems	2016
Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like effect of Wuling mycelia powder in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 78 Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Feeding Behavior; Food Preferences; Hippocampus; Indazoles; Male; Methylene Blue; Mycelium; Nitric Oxide; Powders; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Stress, Psychological; Sucrose	2016
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism. Nitric oxide : biology and chemistry, 2016, 08-31, Volume: 58 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents	2016
The Importance of L-Arginine:NO:cGMP Pathway in Tolerance to Flunitrazepam in Mice. Neurotoxicity research, 2017, Volume: 31, Issue:2 Topics: Animals; Arginine; Cyclic GMP; Drug Interactions; Drug Tolerance; Flunitrazepam; Indazoles; Male; Mice; Motor Skills; NG-Nitroarginine Methyl Ester; Nitric Oxide; Signal Transduction; Sildenafil Citrate	2017
The role of nitric oxide-cGMP pathway in selegiline antidepressant-like effect in the mice forced swim test. Pharmacological reports : PR, 2018, Volume: 70, Issue:5 Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Drug Synergism; Fluoxetine; Guanidines; Hippocampus; Immobility Response, Tonic; Indazoles; Male; Methylene Blue; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Prefrontal Cortex; Selegiline; Signal Transduction; Sildenafil Citrate; Swimming	2018
Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test. Behavioural brain research, 2019, 05-17, Volume: 364 Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Dizocilpine Maleate; Glucagon-Like Peptide 2; Indazoles; Male; Methylene Blue; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Sildenafil Citrate; Swimming	2019