Page last updated: 2024-08-21

indazoles and a 443654

indazoles has been researched along with a 443654 in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (40.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	1 (4.00)	2.80

Authors

Authors	Studies
Bouska, JJ; de Jong, R; Giranda, VL; Gramling-Evans, EE; Guan, R; Han, EK; Johnson, EF; Klinghofer, V; Leverson, JD; Li, Q; Li, T; Liu, X; Luo, Y; Mamo, M; McGonigal, TP; Mika, AK; Mitten, MJ; Nguyen, PT; Oleksijew, A; Oltersdorf, T; Powlas, JA; Rosenberg, SH; Shi, Y; Shoemaker, AR; Smith, RA; Stoll, VS; Thomas, SA; Woods, KW; Zinker, BA	1
Anderson, MG; Fesik, SW; Giranda, VL; Leverson, JD; Li, Q; Luo, Y; Morgan-Lappe, S; Schurdak, ME; Woods, KW	1
Fisher, JP; Giranda, VL; Guan, R; Han, EK; Klinghofer, V; Lasko, L; Li, Q; Liu, X; Luo, Y; McGonigal, T; Oleksijew, A; Rosenberg, SH; Shi, Y; Shoemaker, AR; Woods, KW	1
Giranda, VL; Han, EK; Hunter, T; Leverson, JD; Luo, Y; McGonigal, T; Shah, OJ; Woods, KW	1
Harwood, FC; Houghton, PJ; Kurmasheva, RT	1
Blalock, WL; Cappellini, A; Chiarini, F; Cocco, L; Falà, F; Martelli, AM; Martinelli, G; McCubrey, JA; Tafuri, A; Tazzari, PL	1
Giranda, VL; Hessler, P; Kroeger, P; Li, C; Li, Q; Liu, X; Luo, Y; Rosenberg, SH; Shi, Y; Wang, J; Wang, JY; Wilsbacher, J; Woods, KW	1
Brem, H; Gallia, GL; Giranda, VL; Hann, CL; Riggins, GJ; Siu, IM; Tyler, BM; Vescovi, AL	1
Aizenstein, B; Fiedler, D; Gray, DC; Hoffman, R; Okuzumi, T; Shokat, KM; Zhang, C	1
Carter, A; Cawley, JC; Glenn, MA; Hawkins, SF; Johnson, GG; Lin, K; Pettitt, AR; Zhuang, J	1
Coll-Mulet, L; Cosialls, AM; de Frias, M; de la Banda, E; Gil, J; González-Gironès, DM; Iglesias-Serret, D; Pons, G; Santidrián, AF	1
Bilodeau, M; Cherrin, C; Defeo-Jones, D; Hartman, G; Haskell, K; Hoffman, J; Howell, B; Huber, HE; Jiang, G; Jones, R; Leander, K; Mahan, E; Prueksaritanont, T; Robinson, R; Rosen, N; Sanderson, P; Sepp-Lorenzino, L; She, QB; Watkins, A	1
Hudder, A; Novak, RF; Zheng, J; Zukowski, K	1
Aizenstein, B; Ducker, GS; Hoffman, R; Okuzumi, T; Shokat, KM; Zhang, C	1
Bold, RJ; Coates, J; Muilenburg, D; Parsons, C; Virudachalam, S	1
Erlichman, C; Flatten, KS; Gálvez-Peralta, M; Kaufmann, SH; Loegering, DA; Peterson, KL; Schneider, PA	1
Costa-Mattioli, M; Huang, W; Johnson, JL; Roman, G	1
Chen, KH; Curtis, J; Dasgupta, A; Ghosh, P; Longo, DL; Munk, RB; Sasaki, CY	1
Baudry, M; Bi, X; Liu, Y; O'Neal, P; Sun, J; Tran, J	1
Austreid, E; Eikesdal, HP; Knappskog, S; Lønning, PE; Svanberg, IR; Yndestad, S	1
He, L; Liu, MY; Liu, Y; Xing, FZ; Zhang, JQ; Zhang, YY; Zhao, JK; Zhao, YG	1
Laguesse, S; Morisot, N; Phamluong, K; Ron, D; Sakhai, SA	1
Fu, X; Halim, A; Luo, Q; Song, G; Tian, B	1
Ahn, BY; Jeong, GU	1
Aoyama, E; Dansithong, W; Dexheimer, T; Gandelman, M; Henderson, MJ; Huynh, DP; Jadhav, A; Kales, SC; Maag, G; Paul, S; Pulst, SM; Rai, G; Scoles, DR; Simeonov, A; Sun, H; Whitehill, BM; Zakharov, A	1

Other Studies

25 other study(ies) available for indazoles and a 443654

Article	Year
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Molecular cancer therapeutics, 2005, Volume: 4, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Progression; Humans; Indazoles; Indoles; Mice; Mice, SCID; Models, Molecular; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Sensitivity and Specificity; Substrate Specificity	2005
RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. Oncogene, 2006, Mar-02, Volume: 25, Issue:9 Topics: Antineoplastic Agents; Casein Kinase I; Cell Death; Genetic Testing; Humans; Indazoles; Indoles; Isoenzymes; Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction	2006
Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo. Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:11 Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Design; Enzyme Inhibitors; Humans; Indazoles; Indoles; Kinetics; Paclitaxel; Proto-Oncogene Proteins c-akt	2005
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene, 2007, Aug-16, Volume: 26, Issue:38 Topics: Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Serine; Time Factors; TOR Serine-Threonine Kinases; Transcription Factors; Transfection; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins	2007
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors. Molecular cancer therapeutics, 2007, Volume: 6, Issue:5 Topics: Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoxia; Indazoles; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxygen; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A	2007
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. Molecular pharmacology, 2008, Volume: 74, Issue:3 Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; Etoposide; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indazoles; Indoles; Leukemia-Lymphoma, Adult T-Cell; Phosphorylation; Phosphoserine; Phosphothreonine; Proto-Oncogene Proteins c-akt	2008
Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:8 Topics: Aurora Kinases; Cell Division; Cell Line, Tumor; Centrosome; Dose-Response Relationship, Drug; Down-Regulation; G2 Phase; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Indazoles; Indoles; Mitosis; Molecular Structure; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger; Spindle Apparatus; Stereoisomerism	2008
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Molecular cancer therapeutics, 2009, Volume: 8, Issue:2 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Central Nervous System; Class I Phosphatidylinositol 3-Kinases; Enzyme Activation; Female; Glioblastoma; Humans; Indazoles; Indoles; Mutation; Neoplastic Stem Cells; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Survival Analysis	2009
Inhibitor hijacking of Akt activation. Nature chemical biology, 2009, Volume: 5, Issue:7 Topics: Binding, Competitive; Cell Line; Cell Membrane; Drug Discovery; Enzyme Activation; Humans; Indazoles; Indoles; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection	2009
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica, 2010, Volume: 95, Issue:1 Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Clone Cells; Enzyme Activation; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Proto-Oncogene Proteins c-akt; Signal Transduction	2010
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica, 2009, Volume: 94, Issue:12 Topics: Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; B-Lymphocytes; Benzylamines; Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tumor Suppressor Protein p53	2009
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo. Cancer biology & therapy, 2010, Apr-01, Volume: 9, Issue:7 Topics: Allosteric Regulation; Animals; Glucose; Humans; Hyperglycemia; Indazoles; Indoles; Insulin; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthyridines; Phosphorylation; Prostatic Neoplasms; Protein Transport; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tissue Distribution; Xenograft Model Antitumor Assays	2010
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer letters, 2010, Oct-01, Volume: 296, Issue:1 Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Female; Fibrocystic Breast Disease; Flow Cytometry; Humans; Immunoblotting; Indazoles; Indoles; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Sirolimus; Survivors	2010
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Molecular bioSystems, 2010, Volume: 6, Issue:8 Topics: Cells, Cultured; Drug Evaluation, Preclinical; Humans; Indazoles; Indoles; Models, Biological; Models, Molecular; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Substrate Specificity	2010
Role of autophagy in apoptotic regulation by Akt in pancreatic cancer. Anticancer research, 2014, Volume: 34, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Enzyme Activation; Humans; Indazoles; Indoles; Microscopy, Fluorescence; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sirolimus; TOR Serine-Threonine Kinases	2014
Context-dependent antagonism between Akt inhibitors and topoisomerase poisons. Molecular pharmacology, 2014, Volume: 85, Issue:5 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; HCT116 Cells; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Indoles; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Poisons; Proto-Oncogene Proteins c-akt; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors	2014
TORC2: a novel target for treating age-associated memory impairment. Scientific reports, 2015, Oct-22, Volume: 5 Topics: Actins; Animals; Drosophila melanogaster; Gene Expression Regulation; Hippocampus; Humans; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 2; Memory Disorders; Memory, Long-Term; Mice; Multiprotein Complexes; Neuronal Plasticity; TOR Serine-Threonine Kinases	2015
Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells. Journal of immunology (Baltimore, Md. : 1950), 2015, Dec-15, Volume: 195, Issue:12 Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Down-Regulation; GTP Phosphohydrolases; Humans; Indazoles; Indoles; Leukocytes, Mononuclear; Lymphocyte Activation; Mitochondrial Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirolimus; T-Lymphocytes; TOR Serine-Threonine Kinases	2015
mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice. Cellular and molecular life sciences : CMLS, 2016, Volume: 73, Issue:22 Topics: Actins; Angelman Syndrome; Animals; Blood Proteins; Cytoskeletal Proteins; Hippocampus; Imidazoles; Indazoles; Indoles; Learning; Long-Term Potentiation; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Nerve Tissue Proteins; Neuronal Plasticity; Piperazines; Polymerization; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2016
Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines. Oncotarget, 2017, Jun-20, Volume: 8, Issue:25 Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Indoles; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Xenograft Model Antitumor Assays	2017
Nuclear and membrane estrogen receptor antagonists induce similar mTORC2 activation-reversible changes in synaptic protein expression and actin polymerization in the mouse hippocampus. CNS neuroscience & therapeutics, 2018, Volume: 24, Issue:6 Topics: Actins; Animals; Benzodioxoles; Enzyme Inhibitors; Estrogen Receptor Antagonists; Female; Hippocampus; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Nuclear Receptor Coactivator 1; Polymerization; Pyrazoles; Pyrimidines; Quinolines; Signal Transduction; Silver Staining; Synapses	2018
mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:7 Topics: Actins; Alcohol Drinking; Animals; Corpus Striatum; Dendritic Spines; Ethanol; Gene Knockdown Techniques; Indazoles; Indoles; Mechanistic Target of Rapamycin Complex 2; Mice; Polymerization; Rapamycin-Insensitive Companion of mTOR Protein	2018
MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells. Journal of cellular physiology, 2019, Volume: 234, Issue:8 Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Chromones; Gene Expression Regulation, Developmental; Humans; Indazoles; Indoles; Matrix Metalloproteinase 14; Mesenchymal Stem Cells; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Signal Transduction; Stress, Mechanical	2019
Aurora kinase A promotes hepatitis B virus replication and expression. Antiviral research, 2019, Volume: 170 Topics: Antiviral Agents; Aurora Kinase A; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Hep G2 Cells; Hepatitis B virus; Humans; Indazoles; Indoles; Virus Replication	2019
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy. The Journal of biological chemistry, 2021, Volume: 297, Issue:4 Topics: alpha-Synuclein; Autophagy; Endoplasmic Reticulum Stress; Gene Expression Regulation; HEK293 Cells; Humans; Indazoles; Indoles; Parkinson Disease; Proto-Oncogene Proteins c-akt	2021