indazoles has been researched along with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole in 317 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (8.52) | 18.2507 |
| 2000's | 156 (49.21) | 29.6817 |
| 2010's | 123 (38.80) | 24.3611 |
| 2020's | 11 (3.47) | 2.80 |
| Authors | Studies |
|---|---|
| Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC | 3 |
| Cheng, ZJ; Guh, JH; Kuo, SC; Lee, FY; Yu, SM | 1 |
| Bauersachs, J; Busse, R; Kast, R; Mülsch, A; Schäfer, A; Stasch, JP | 1 |
| Ko, FN; Teng, CM; Wu, CC | 1 |
| Nawrath, H; Wegener, JW | 1 |
| Förstermann, U; Gath, I; Nawrath, H; Wegener, JW | 1 |
| Friebe, A; Koesling, D | 1 |
| Hebeiss, K; Kilbinger, H | 1 |
| Marletta, MA; Stone, JR | 1 |
| La, M; Schmidt, HH; Weeger, M; Zabel, U | 1 |
| Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
| Friebe, A; Koesling, D; Müllershausen, F; Schultz, G; Smolenski, A; Walter, U | 1 |
| Kharitonov, VG; Koesling, D; Magde, D; Sharma, VS | 2 |
| Apeler, H; Becker, EM; Gerzer, R; Hoenicka, M; Schröder, H; Sirichoke, T; Stasch, JP | 1 |
| Faraci, FM; Sobey, CG | 1 |
| Corbalán, R; Felipo, V; Miñana, MD; Montoliu, C; Teng, CM | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| Clement, B; Feelisch, M; Kotsonis, P; Schmidt, HH; Siebe, J | 1 |
| Hwang, TL; Teng, CM; Wu, CC | 1 |
| Kuo, SC; Lee, FY; Teng, CM; Wu, CC | 1 |
| Gerhard, R; Jost, A; Nawrath, H; Ochi, R; Rupp, J; Seitz, S; Shainberg, A; Watanabe, M; Wegener, JW | 1 |
| Hobbs, AJ; Hussain, MB; MacAllister, RJ | 1 |
| Friebe, A; Koesling, D; Mergia, E; Russwurm, M | 1 |
| Linz, W; Malinski, T; Ruetten, H; Schindler, U; Schoenafinger, K; Strobel, H; Wiemer, G; Wohlfart, P | 1 |
| Mullan, M; Paris, D; Town, T | 1 |
| Margulis, A; Sitaramayya, A | 1 |
| Becker, EM; Gerzer, R; Hoenicka, M; Schmidt, P; Schramm, M; Schröder, H; Stasch, JP; Walter, U | 1 |
| Babcock, GT; Brandish, PE; Denninger, JW; Marletta, MA; Schelvis, JP; Zhao, Y | 1 |
| Brien, JF; Choi, C; Chretien, ML; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Friebe, A; Koesling, D; Kreutz, R; Paul, M; Rothermund, L | 1 |
| Hwang, T; Jan, CR; Li, HF; Teng, CM; Wu, SN | 1 |
| Bureau, I; Collot, V; Rault, S; Sopková-De Oliveira Santos, J | 1 |
| Chapman, GB; Durante, W; Evans, AJ; Peyton, KJ; Schafer, AI; Tulis, DA | 1 |
| Koesling, D; Mayer, B; Schmidt, K; Schrammel, A | 1 |
| Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K; O'Reilly, DA | 1 |
| Alonso-Alija, C; Apeler, H; Becker, EM; Dembowsky, K; Feurer, A; Gerzer, R; Minuth, T; Perzborn, E; Pleiss, U; Schramm, M; Schröder, H; Schroeder, W; Stahl, E; Stasch, JP; Steinke, W; Straub, A | 1 |
| Chiang, HT; Li, HF; Wu, SN | 1 |
| Alonso-Alija, C; Benet-Buchholz, J; Ducke, B; Feurer, A; Fürstner, C; Stasch, JP; Straub, A | 1 |
| Bae, JM; Choi, E; Chun, YS; Kim, MS; Park, JW; Teng, CM; Yeo, EJ | 1 |
| Bruckdorfer, KR; Friebe, A; Koesling, D; Naseem, KM; Sabetkar, M; Tullett, JM | 1 |
| Corbalán, R; Córdoba, J; Felipo, V; López-Talavera, J; Martinez, L; Monfort, P | 1 |
| Artz, JD; Bennett, BM; Thatcher, GR; Toader, V; Zavorin, SI | 1 |
| Becker, C; Bergemann, C; Fischer, Y; Graf, B; Hamidizadeh, M; Löken, C | 1 |
| Chang, LC; Huang, LJ; Kuo, SC; Wang, JP | 1 |
| Cheng, FC; Huang, LJ; Huang, TM; Kuo, SC; Lee, FY; Lien, JC; Teng, CM; Tsai, SC; Wu, CC | 1 |
| Makino, R; Suematsu, M; Suzuki, T | 1 |
| Ferrero, R; Torres, M | 1 |
| Lee, YC; Martin, E; Murad, F | 1 |
| Counts Gerber, N; Kosarikov, DN; Lee, JM; Uversky, VN | 1 |
| Garthwaite, G; Garthwaite, J; Goodwin, DA; Neale, S; Riddall, D | 1 |
| Alonso-Alija, C; Apeler, H; Becker, EM; Gerzer, R; Minuth, T; Pleiss, U; Schmidt, P; Schramm, M; Schröder, H; Schroeder, W; Stasch, JP; Steinke, W; Straub, A | 1 |
| Alajuuma, P; Kotikoski, H; Laippala, P; Moilanen, E; Oksala, O; Salmenperä, P; Vapaatalo, H | 1 |
| Bohl Masters, KS; Durante, W; Evans, AJ; Lipke, EA; Peyton, KJ; Schafer, AI; Schiesser, RL; Tulis, DA; West, JL | 1 |
| Brioni, JD; Hsieh, GC; Kolasa, T; Moreland, RB; Nakane, M; Sullivan, JP | 1 |
| Andersson, KE; Hedlund, P; Schroder, A | 1 |
| Allen, JC; Kahn, AM; Zhang, S | 1 |
| Behrends, S; Koglin, M; Stasch, JP | 1 |
| Andersson, KE; Brioni, JD; Hedlund, P; Mizusawa, H; Sullivan, JP | 1 |
| Bellamy, TC; Garthwaite, J | 1 |
| Koesling, D; Mergia, E; Mullershausen, F; Russwurm, M | 1 |
| Brioni, JD; Chang, R; Hsieh, G; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M; Terranova, MA | 1 |
| Chang, LC; Hsu, MF; Huang, LJ; Kuo, SC; Raung, SL; Wang, JP | 1 |
| Chang, MS; Hsiao, G; Lee, HM; Lee, WS; Lin, CH; Sheu, JR; Teng, CM | 1 |
| Ndisang, JF; Wang, R; Zhao, W | 1 |
| Guh, JH; Huang, LJ; Kuo, SC; Lee, FY; Lien, JC; Pan, SL; Teng, CM | 1 |
| Homer, KL; Wanstall, JC | 1 |
| Furneaux, H; Kloss, S; Mülsch, A | 1 |
| Brioni, JD; Chang, R; Hsieh, GC; Kolasa, T; Miller, LN; Moreland, RB; Nakane, M | 1 |
| Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP | 1 |
| Homma, N; Hori, H; Makino, R; Obayashi, E; Shiro, Y | 1 |
| Behrends, S; Koglin, M | 1 |
| Che, Y; Li, CG; Rand, MJ | 1 |
| Donehower, RC; Pili, R | 1 |
| Cho, YS; Chun, YS; Kim, J; Kim, MS; Lee, JC; Park, JW; Yeo, EJ | 1 |
| Bredt, DS | 1 |
| Chien, WL; Fu, WM; Kuo, SC; Lee, FY; Liang, KC; Teng, CM | 2 |
| Guh, JH; Hwang, TL; Teng, CM; Wu, CC | 1 |
| Ho, PY; Hsu, HK; Juan, SH; Lee, WS; Liang, YC; Lin, CH; Teng, CM | 1 |
| Schmidt, P; Schramm, M; Schröder, H; Stasch, JP | 1 |
| Cheng, SJ; Hung, HW; Hwang, TL; Kao, SH; Teng, CM; Wu, CC | 1 |
| Chan, JY; Chan, SH; Chang, AY | 1 |
| Dannenberg, AJ; Das, KM; Glazier, KD; Golijanin, D; Naraba, H; Scherl, E; Soslow, RA; Subbaramaiah, K; Tanabe, T; Yoshimatsu, K | 1 |
| Chang, YL; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Teng, CM | 1 |
| Adragna, NC; Di Fulvio, M; Lauf, PK | 1 |
| Cetin, A; Cetin, M; Demirkoprulu, N; Duran, B; Karadas, B; Kaya, T | 1 |
| Gao, H; Kaminski, A; Morgan, NG | 1 |
| Browner, NC; Lincoln, TM; Sellak, H | 1 |
| Fong, TH; Hsiao, G; Huang, HY; Lin, CH; Shen, MY; Sheu, JR; Teng, CM | 1 |
| Balashova, N; Beuve, A; Chang, FJ; Lamothe, M; Shirokov, R | 1 |
| Chang, GY; Chang, WC; Kuo, SC; Teng, CM; Wu, CH | 1 |
| Cwiklicki, A; Rehse, K | 1 |
| Friebe, A; Koesling, D; Mullershausen, F; Russwurm, M | 1 |
| Chun, YS; Park, JW; Yeo, EJ | 2 |
| Kitagawa, T; Li, Z; Ohta, T; Pal, B; Takenaka, S; Tsuyama, S | 1 |
| Baughman, VL; Gavrilyuk, V; Pelligrino, DA; Wolde, HM; Xu, HL | 1 |
| Imai, A; Komine, N; Nashida, T; Shimomura, H; Shimooka, S; Tanaka, S | 1 |
| Tulis, DA | 1 |
| Chang, MS; Chen, BC; Lee, WS; Lin, CH; Sheu, JR | 1 |
| Delago, A; Elphick, MR; Ott, SR | 1 |
| Cogolludo, A; Gonzalez-Luis, G; Lodi, F; Lopez-Farre, A; Moreno, L; Perez-Vizcaino, F; Tamargo, J; Villamor, E | 1 |
| Chen, JY; Lapolt, PS; Stewart, RL; Tafoya, MA | 1 |
| Chen, YS; Huang, LJ; Kuo, SC; Tsai, CR; Wang, JP | 1 |
| Chang, YL; Chen, HL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Pan, SL; Teng, CM; Wang, SW | 1 |
| Alberto, R; Bains, S; Foresti, R; Green, CJ; Hammad, J; Motterlini, R; Sawle, P | 1 |
| Clottes, E | 1 |
| Cole, KR; Lanning, KM; Linder, AE; McCluskey, LP; Webb, RC | 1 |
| Chang, JH; Chang, YL; Cheng, FC; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Peng, CY; Teng, CM; Wang, SW | 1 |
| Czarnecki, K; Jayaraman, V; Kincaid, J; Martin, E; Murad, F | 1 |
| Bundgaard, H; Clarke, RJ; Garcia, A; Hamilton, E; Rasmussen, HH; Vien, J; William, M | 1 |
| Chang, JH; Chang, YL; Cheng, FC; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Peng, CY; Teng, CM | 1 |
| Elsner, N; Ganter, GK; Günther, C; Heinrich, R; Kunst, M; Lakes-Harlan, R; Wenzel, B | 1 |
| Chen, YM; Chiang, WC; Hsieh, BS; Lin, SL; Teng, CM; Tsai, TJ | 1 |
| Bagcivan, I; Cetin, A; Cetin, M; Demirkoprulu, N; Karadas, B; Kaya, T; Soydan, AS | 1 |
| Che, Y; Ellis, A; Li, CG | 1 |
| Garber, K | 1 |
| Cheng, JT; Liao, CH; Teng, CM | 1 |
| Funasaka, T; Hogan, V; Raz, A; Yanagawa, T | 1 |
| D'Alecy, LG; Linder, AE; Webb, RC; Weber, DS; Whitesall, SE | 1 |
| Chang, YL; Guh, JH; Huang, DM; Kuo, SC; Lee, FY; Lin, CH; Liu, YN; Pai, HC; Pan, SL; Peng, CY; Teng, CM | 1 |
| Chang, YL; Guh, JH; Huang, YT; Kuo, SC; Lee, FY; Pan, SL; Teng, CM | 1 |
| Artz, JD; Hering, KW; Marletta, MA; Pearson, WH | 1 |
| Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Liu, YC; Wu, SN | 1 |
| Cogolludo, A; González-Luis, G; Lodi, F; Moreno, L; Pérez-Vizcaíno, F; Tamargo, J; Villamor, E | 1 |
| Bagcivan, I; Duman, M; Karadas, B; Kaya, T; Sarac, B; Turan, M | 1 |
| Ponomarev, GV; Pyatakova, NV; Severina, IS; Shchegolev, AY | 1 |
| Ahnen, DJ; Beard, KS; Peters, SL; Rice, PL | 1 |
| Chlopicki, S; Lomnicka, M; Marcinkiewicz, E; Motterlini, R; Olszanecki, R | 1 |
| Chun, YS; Kim, HL; Park, JW; Yeo, EJ | 1 |
| Cho, H; Cho, YS; Chun, YS; Jang, IJ; Kim, J; Kim, MS; Park, JW; Ryu, JH; Yeo, EJ | 1 |
| Fan, ST; Lam, CT; Lau, CK; Poon, RT; Tam, KH; Yang, ZF | 1 |
| Dive, C; Estlin, EJ; Hussein, D; Makin, GW | 1 |
| Du, J; Gu, H; Liu, NZ; Qin, H; Teng, XL; Zhao, Q | 1 |
| Abdallah, Y; Euler, G; Piper, HM; Schlüter, KD; Tastan, H | 1 |
| Chou, LC; Huang, LJ; Kuo, SC; Lee, FY; Teng, CM; Yang, JS | 1 |
| Guh, JH; Huang, DY; Huang, YT; Kuo, SC; Lee, FY; Liu, YN; Pan, SL; Sun, HL; Teng, CM | 1 |
| Du, J; Gu, H; Liu, N; Qin, H; Teng, X; Zhang, Q; Zhao, Q | 1 |
| Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF | 1 |
| Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM | 1 |
| Hiraga, T; Hiraoka, M; Hirota, K; Kizaka-Kondoh, S; Yoneda, T | 1 |
| Chun, YS; Jeong, JM; Jung, YJ; Kim, JH; Kim, KE; Park, JW; Shin, DH | 1 |
| Fu, WM; Lin, CJ; Liou, HC; Lu, DY; Yeh, WL | 1 |
| Bilodeau, ML; Hamm, HE | 1 |
| Grześk, G; Jasiński, M; Masztalerz, M; Piotrowiak, I; Slupski, M; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R; Wlodarczyk, Z | 1 |
| Derbyshire, ER; Marletta, MA; Martin, NI | 1 |
| Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J | 1 |
| Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S | 1 |
| Huang, CT; Liao, CH; Lin, CY; Lin, YC; Tsai, IF; Yang, CM | 1 |
| Chung, JG; Huang, LJ; Kuo, SC; Lee, FY; Lin, KL; Teng, CM; Tsai, SC; Wang, SF; Yang, JS | 1 |
| Chen, CJ; Chung, JG; Hsu, MH; Huang, LJ; Kuo, SC; Lee, FY; Teng, CM; Yamori, T | 1 |
| Hwang, TL; Pan, YL; Zhuo, SK | 1 |
| Chung, H; Song, SJ; Yu, HG | 1 |
| Fan, ST; Lam, CT; Lam, SP; Lau, CK; Ngai, P; Poon, RT; Tam, KH; Yang, ZF | 1 |
| Amir, S; Mabjeesh, NJ | 1 |
| Guh, JH; Huang, DY; Kuo, SC; Lee, FY; Liu, YN; Pan, SL; Peng, CY; Teng, CM | 1 |
| Green, AK; Squires, PE; Stratton, RC | 1 |
| Garthwaite, J; Halvey, EJ; Roy, B | 1 |
| Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P | 1 |
| Chien, WL; Fu, WM; Liang, KC | 1 |
| Chang, YL; Chen, TH; Guh, JH; Huang, DY; Kuo, SC; Lee, FY; Liao, CH; Pan, SL; Teng, CM; Wu, SY | 1 |
| Akai, Y; Haase, VH; Harada, K; Higgins, DF; Iwano, M; Kimura, K; Kubo, A; Nakatani, K; Neilson, EG; Rankin, EB; Saito, Y; Yamaguchi, Y | 1 |
| Geng, MY; Li, J; Wang, JJ | 1 |
| Durante, W; Liu, XM; Mendelev, NN; Peyton, KJ; Tulis, DA; Wang, H | 1 |
| Feng, C; Hazzard, JT; Hu, X; Montfort, WR; Tollin, G | 1 |
| Chun, YS; Kim, MS; Lee, MK; Li, SH; Park, JW; Shin, DH | 1 |
| Gu, Y; Heth, J; Hua, Y; Keep, RF; Muraszko, KM; Xi, G; Xu, Y | 1 |
| Harada, H; Hiraoka, M; Itasaka, S; Morinibu, A; Shinomiya, K; Xie, X; Zeng, L; Zhu, Y | 1 |
| Dismuke, WM; Ellis, DZ; Sharif, NA | 1 |
| Aydin, C; Bagcivan, I; Koyuncu, A; Ozer, H; Soylu, S; Topcu, O; Yildirim, S | 1 |
| Durante, W; Keswani, AN; Peyton, KJ; Schafer, AI; Tulis, DA | 1 |
| Kohr, MJ; Traynham, CJ; Wang, H; Ziolo, MT | 1 |
| Li, JK; Pei, ZZ; Wang, SX; Wu, XH; Yang, YJ | 1 |
| Chang, HW; Cho, KJ; Choi, SH; Kim, GC; Kim, SY; Lee, SW; Moon, SY; Nam, SY; Roh, JL | 1 |
| Bae, J; Kim, YJ; Lee, CS; Lee, SJ | 1 |
| Al-Mohanna, F; Alsmadi, O; DeNiro, M | 1 |
| García-Flores, M; García-Pascual, A; Sancho, M; Triguero, D | 1 |
| Chang, MS; Chen, BC; Lee, WS; Lin, CH; Weng, CM | 1 |
| Chan, AT; Cheng, SH; Hong, B; Hui, EP; Leung, HS; Lu, Y; Lui, VW; Mills, GB; Ng, MH; Wong, EY | 1 |
| Agar, A; Akpinar, D; Savcioglu, F; Yargicoglu, P | 1 |
| Al-Halafi, A; Al-Mohanna, FA; Al-Mohanna, FH; Alsmadi, O; DeNiro, M | 1 |
| Koh, MY; Powis, G; Spivak-Kroizman, TR | 1 |
| Choi, TH; Han, J; Hong, DH; Jung, ID; Kim, N; Ko, EA; Ko, JH; Park, WS; Park, YM; Son, YK | 1 |
| Choi, I; Jeong, M; Kang, YH; Kim, MJ; Kim, MS; Kim, TD; Lee, SH; Myung, PK; Piao, ZH; Suh, HW; Yoon, SR; Yun, S | 1 |
| Bao, W; Chen, BA; Cheng, J; Ding, JH; Gao, C; Gao, F; Pei, XP; Shan, XY; Song, HH; Sun, YY; Wang, F; Wang, J; Wang, XM; Wu, WW; Xia, GH; Xu, WL; Yin, L; Zhang, W; Zhao, G | 1 |
| Bicker, G; Böger, N; Eickhoff, R; Holstein, GR; Kerssen, U; Lorbeer, C; Martinelli, GP; Stern, M; Ziegler, M | 1 |
| Beart, PM; Chu, PW; Jones, NM | 1 |
| Chen, C; Ostrowski, RP; Tang, J; Zhang, JH; Zhou, C | 1 |
| Derbyshire, ER; Ibrahim, M; Marletta, MA; Spiro, TG | 1 |
| Derbyshire, ER; Ibrahim, M; Marletta, MA; Soldatova, AV; Spiro, TG | 1 |
| Kitagawa, T; Pal, B | 1 |
| Gou, S; Liu, T; Wang, C; Wang, L; Wang, T; Zhou, W | 1 |
| Ballini, R; Gabrielli, S; Palmieri, A | 1 |
| Hung, CC; Liou, HH | 1 |
| Billiar, TR; Franks, JM; Huang, CS; McCurry, KR; Nakao, A; Stolz, DB; Tochigi, N; Toyoda, Y; Tzeng, E; Wang, Y | 1 |
| Feng, Y; Hao, B; Ling, T; Shi, R; Zhang, G; Zhu, H | 1 |
| Day, YJ; Hsieh, YH; Huang, SS; Hung, LM; Wei, FC | 1 |
| Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z | 1 |
| Ban, HS; Nakamura, H; Uto, Y | 1 |
| Cao, W; Du, K; Duan, Y; Hu, Y; Huang, H; Lai, X; Lin, J; Liu, L; Wang, Y; Wu, K; Xiao, H; Yu, Q; Zhang, L | 1 |
| Khan, SA; Luo, W; Nanduri, J; Prabhakar, NR; Semenza, GL; Yuan, G | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E | 1 |
| Baskaran, P; Beuve, A; Heckler, EJ; van den Akker, F | 1 |
| Feng, Y; Hao, B; Shi, R; Zhang, G; Zhang, J; Zhou, X; Zhu, H | 1 |
| Kim, W; Kim, YJ; Lee, CS; Myung, SC | 1 |
| Chen, JK; Chung, TH; Huang, DM; Yen-Ping Kuo, M | 1 |
| Shi, H; Yan, J; Zhang, Z | 1 |
| Czyz, M; Duechler, M; Wilczynski, J | 1 |
| Bae, K; Dai, Y; Siemann, DW | 1 |
| Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS | 1 |
| Al-Mohanna, FA; Al-Mohanna, FH; DeNiro, M | 1 |
| Ahn, JH; Chung, JW; Han, KW; Kim, YJ; Park, JW; Shin, JE; So, HS | 1 |
| Li, M; Liu, H; Wang, F; Wang, P | 1 |
| Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R | 1 |
| Jiao, M; Nan, KJ | 1 |
| Hirt, S; Hoenicka, M; Keyser, A; Puehler, T; Rupprecht, L; Schmid, C | 1 |
| Azara, D; Bagnoli, P; Cammalleri, M; Casini, G; Dal Monte, M; Mei, S | 1 |
| Huh, JW; Kim, SY; Lee, JH; Lee, YS | 1 |
| Li, S; Li, Y; Tang, H; Wang, Y; Xu, R; Zhang, L; Zhao, X; Zhong, Z | 1 |
| Allanson, M; Cho, JL; Reeve, VE | 1 |
| Avraham, T; Daluvoy, S; Mehrara, BJ; Weitman, ES; Yan, A; Zampell, JC | 1 |
| Cheng, B; Fung, ML; Leung, WK; Li, FY; Li, JP; Tsao, SW; Xu, A | 1 |
| Shi, H; Taheri, S; Yan, J; Zhou, B | 1 |
| Currier, GF; Dandajena, TC; Disch, B; Ihnat, MA; Thorpe, J | 1 |
| Chang, WD; Chang, YW; Chung, PJ; Fang, YC; Hwang, TL; Kuo, LM; Tang, MC | 1 |
| Kim, W; Kim, YJ; Kwak, SW; Lee, CS; Lee, JJ; Lee, MS; Lee, SA; Myung, SC; Park, ES | 1 |
| Hu, R; Huang, Y; Jiang, H; Li, QF; Xu, H | 1 |
| Cheng, HC; Cheng, Y; Li, W; Liu, Y; Ma, J; Qiu, L | 1 |
| Badawi, Y; Ramamoorthy, P; Shi, H | 1 |
| Dong, S; Ke, S; Kong, J; Li, X; Pan, B; Sun, WB; Zheng, L; Zhou, A | 1 |
| Chang, CC; Chen, SP; Chin, CH; Fong, TH; Pai, MH; Tsai, FC; Wang, KC | 1 |
| Cao, J; Guo, B; Liang, D; Yang, L; Yang, M; Zhang, X | 1 |
| Fong, TH; Tsui, L; Wang, IJ | 2 |
| Aharoni-Simon, M; Anavi, S; Beifuss, U; Madar, Z; Tirosh, O | 1 |
| Hao, X; Li, S; Nie, X; Shi, S; Song, S; Yao, L; Zhu, D | 1 |
| Chen, RM; Cheng, HA; Chio, CC; Chiu, WT; Hsing, CH; Lin, JW; Wang, JJ; Wang, YH | 1 |
| Benakanakere, I; Besch-Williford, C; Carroll, CE; Hyder, SM; Liang, Y | 1 |
| Bagnoli, P; Dal Monte, M; Landi, D; Martini, D | 1 |
| Al-Mohanna, FA; Deniro, M | 1 |
| Cheng, PY; Ding, C; Lam, KK; Lee, YM; Liu, WH; Liu, YP; Yen, MH | 1 |
| Brennan, KR; Clarke, RB; Gregson, HJ; Harrison, H; Landberg, G; Rogerson, L | 1 |
| Akong-Moore, K; Broide, DH; Cho, JY; Cowburn, AS; Crotty Alexander, LE; Feldstein, S; Isaacs, H; Johansson, P; Johnson, RS; McEachern, EK; Nguyen, A; Nicatia, S; Nizet, V; Olson, J | 1 |
| Ahmed, A; Brailey, JL; Breci, L; Fritz, BG; Li, W; Montfort, WR; Roberts, SA; Tama, F; Weichsel, A; Wysocki, VH | 1 |
| Bartsch, S; Klettner, A; Lassen, J; Roider, J; Westhues, D | 1 |
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| Chen, Z; Lin, H; Liu, H; Sun, Q; Yuan, G; Zhang, L; Zhou, Q | 1 |
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| Cheng, PY; Lam, KK; Lee, YM; Lin, JF; Tsai, YC; Wang, JJ; Yen, MH | 1 |
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| Bascands, JL; Bouloumié, A; Decaunes, P; Gres, S; Langin, D; Rancoule, C; Saulnier-Blache, JS; Valet, P; Viaud, M; Viguerie, N | 1 |
| Bagcivan, I; Karadas, B; Parlak, M; Temiz, TK; Turgut, B; Turgut, NH | 1 |
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| Campbell, E; David, CL; Fritz, BG; Gage, MJ; Garcin, ED; Hausrath, AC; Issaian, A; Montfort, WR; Purohit, R; Rassouli-Taylor, L; The, J; Weichsel, A | 1 |
| Dong, S; Gao, J; Gu, F; Ke, S; Kong, F; Kong, J; Pan, B; Shen, Q; Sun, H; Sun, W; Zhang, Q; Zheng, L | 1 |
| Chen, S; Cohen-Sola, KA; Goydos, JS; Jeong, BS; Koo, J; Li, J; Lin, Y; Mehnert, JM; Shin, SS; Wen, Y | 1 |
| Chen, W; Ding, L; Hou, H; Li, X; Li, Z; Liu, T; Zhao, L | 1 |
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| Chang, LC; Chou, RH; Hsieh, MT; Huang, LJ; Hung, HY; Kuo, SC; Lee, FY; Lin, HY; Teng, CM; Tsai, MT; Yu, YL | 1 |
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| Chen, J; Huang, Y; Jiang, H; Lu, Y; Yan, J | 1 |
| Aricioglu, F; Gacar, N; Komsuoglu Celikyurt, I; Ozer, C; Utkan, T | 1 |
| Chun, YS; Kim, JY; Kim, KS; Kim, SJ; Kim, WK; Lin, H; Nam, JH; Park, JW; Shin, DH; Zhang, YH; Zheng, H | 1 |
| Deng, LL; Lin, P; Liu, Y; Lu, C; Qin, Z; Sun, L | 1 |
| Cho, IR; Chung, YH; Jung, CR; Kang, HY; Kaowinn, S; Koh, SS; Moon, J; Oh, S; Soh, J; Song, H | 1 |
| Guo, S; Jin, C; Liu, Z; Wu, X; Xiao, J; Zhang, X; Zhou, X | 1 |
| Brownfoot, FC; Cannon, P; Hannan, NJ; Hastie, R; Kaitu'u-Lino, TJ; Tong, S; Tuohey, L | 1 |
| Chang, SF; Fong, TH; Huang, HP; Tsui, L; Wang, IJ | 1 |
| Barnes, J; Block, K; Cavaglierii, RC; Friedrichs, WE; Nayak, BK; Patel, M; Shanmugasundaram, K | 1 |
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| Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M | 1 |
| Cheng, B; Huang, C; Qian, SL; Sun, LY | 1 |
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| Gao, X; Jiang, T; Li, C; Li, J; Li, N; Tian, F; Wang, X; Wu, C; Zhang, L | 1 |
| Ikezawa, Y; Mizugaki, H; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J | 1 |
| Fu, W; Gao, X; Hao, X; Ke, X; Ma, N; Wang, W; Wu, J; Zhang, H; Zhang, Z; Zhao, M | 1 |
| Ben-Jonathan, N; Kumar, B; Kumar, P; Takiar, V; Tuttle, TR | 1 |
| Duan, D; Ge, L; Lu, M; Wang, H; Wang, L; Wu, P; Yuan, T; Zhuo, Y | 1 |
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| Chen, J; Chen, MY; Guan, XD; Liu, YJ; Ouyang, B; Sun, HD | 1 |
| Alvarado, BA; García-Estrada, J; Lemus, M; Luquín, S; Melnikov, V; Montero, S; Roces de Álvarez-Buylla, E | 1 |
| Chen, H; Hao, K; Liu, J; Liu, W; Wang, G; Wang, W; Yan, F; Zhang, J; Zhou, F | 1 |
| Aishima, S; Kaneki, M; Kitajima, Y; Nakamura, J; Noshiro, H; Tanaka, T; Wakiyama, K; Yanagihara, K | 1 |
| Chen, TH; Chen, WY; Chien, JL; Chou, SJ; Chu, TH; Lu, KC; Shyu, JF; Wang, JW; Yeh, CB; Yen, MH | 1 |
| Biller, M; Harnoss, JM; Keppler, U; Opitz, VM; Radhakrishnan, P; Ritter, AS; Scheer, J; Schmidt, T; Schneider, M; Strowitzki, MJ; Ulrich, A; Wallwiener, M; Wehrmann, J | 1 |
| Antunes, E; Mónica, FZ | 1 |
| Chen, J; Feng, Z; Gao, J; Gatza, ML; Haffty, BG; Hu, W; Huang, S; Khella, CA; Liu, J; Tomsky, K; White, E; Wu, H; Xia, D; Xie, H; Yue, X; Zhang, C; Zhao, Y | 1 |
| Dong, W; Liang, J; Qi, J; Yu, P; Zhang, T; Zhu, C | 1 |
| An, J; Ma, J; Shang, Q; Yan, Z; Zhou, N | 1 |
| Li, X; Li, Z; Zhao, W | 1 |
| Huang, SY; Hung, HY; Lee, AC; Lee, EJ; Lee, WT; Lin, YW; Tai, SH; Wu, TS | 1 |
| Alhallak, K; Dings, RPM; Greene, NP; Griffin, RJ; Jenkins, SV; Lee, DE; Quinn, KP; Rajaram, N; Vargas, I | 1 |
| Lee, EJ; Lee, WT; Lin, YW; Tai, SH; Wu, TS | 1 |
| Gou, S; Li, S; Li, W; Lin, S; Wei, Q; Xu, G; Zhao, J | 1 |
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| Alique, M; Bodega, G; Carracedo, J; Giannarelli, C; Ramírez, R | 1 |
| Gou, S; Huang, X; Wang, H; Zhang, B | 1 |
| Hammel, M; Horst, BG; Hurley, JH; Marletta, MA; Morris, KL; Rosenberg, DJ; Yokom, AL | 1 |
| Cui, W; Hu, H; Liu, D; Xie, R; Zhang, P; Zhang, Y | 1 |
| Hu, H; Hu, MN; Li, JY; Miao, XK; Mou, LY; Xu, JJ; Yang, WL; Zhang, JY; Zhang, XW; Zhou, TX | 1 |
| Koh, Y; Oyanagi, J; Serizawa, M; Shukuya, T; Watanabe, M; Yamamoto, N | 1 |
| Aoki, M; Harada, T; Hirose, K; Ichise, K; Kato, T; Sato, M; Takai, Y; Takeda, K; Wada, Y | 1 |
| Hong, YA; Hwang, HS; Im, DS; Jeong, KH; Jung, SY; Park, CW; Yang, KJ | 1 |
| Du, C; He, G; Liu, X; Ma, Y; Mao, C; Pan, X; Zhu, Y | 1 |
| Damanaki, A; Deschner, J; Jantsch, J; Kirschneck, C; Leikam, A; Memmert, S; Proff, P; Schröder, A; Spanier, G; Thuy, M | 1 |
| Du, G; Kong, L; Liu, C; Liu, N; Ma, G; Ma, Y; Shi, R; Wang, Z | 1 |
| Chen, M; Huang, F; Jiang, N; Jin, Q; Xu, X; Zheng, J | 1 |
| Chi, X; Gao, J; Li, A; Lin, H; Lin, Y; Liu, X; Luo, X; Su, X; Yin, Z; Zhang, L | 1 |
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| Huang, S; Lei, X; Li, Y; Liu, X; Ouyang, C; Tang, G; Wang, Z; Xie, Z; Zhang, J | 1 |
14 review(s) available for indazoles and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
| Article | Year |
|---|---|
Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction.
Topics: Allosteric Site; Animals; Enzyme Activators; Erectile Dysfunction; Guanylate Cyclase; Humans; Indazoles; Male; Solubility | 2002 |
Nitric oxide signaling in brain: potentiating the gain with YC-1.
Topics: Animals; Brain; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide; Signal Transduction | 2003 |
Versatile pharmacological actions of YC-1: anti-platelet to anticancer.
Topics: Animals; Antineoplastic Agents; Cyclic GMP; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neoplasms; Platelet Aggregation Inhibitors; Transcription Factors | 2004 |
New anticancer strategies targeting HIF-1.
Topics: Adaptation, Physiological; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Targeting; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neoplasms; Nuclear Proteins; Transcription Factors | 2004 |
Salutary properties of YC-1 in the cardiovascular and hematological systems.
Topics: Animals; Blood; Cardiovascular System; Cyclic GMP; Enzyme Activators; Humans; Indazoles; Nitric Oxide; Platelet Aggregation Inhibitors | 2004 |
[Hypoxia-inducible factor 1: regulation, involvement in carcinogenesis and target for anticancer therapy].
Topics: Animals; Cell Hypoxia; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoquinolines; Mice; Neoplasm Proteins; Neoplasms; Nuclear Proteins; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transplantation, Heterologous | 2005 |
[Recent progress in the study on antitumor drugs targeting hypoxia-inducible factor-1].
Topics: Amphotericin B; Animals; Antineoplastic Agents; Echinomycin; Humans; Hypoxia-Inducible Factor 1; Indazoles; Sirolimus; Topotecan; Transcription, Genetic | 2008 |
HIF-1alpha and cancer therapy.
Topics: Animals; Cell Hypoxia; Histone Deacetylase Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mustard Compounds; Neoplasms; Phenylpropionates; Proto-Oncogene Proteins c-myc; Tumor Suppressor Protein p53 | 2010 |
Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation.
Topics: Allosteric Regulation; Animals; Binding Sites; Cattle; Drug Synergism; Enzyme Activation; Furans; Guanylate Cyclase; Indazoles; Lung; Models, Chemical; Protein Structure, Tertiary; Protein Subunits; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2010 |
Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010).
Topics: Animals; Antineoplastic Agents; Disulfides; Estradiol; Furans; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Indazoles; Mustard Compounds; Patents as Topic; Phenylpropionates; Piperazines | 2011 |
Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Clinical Trials as Topic; Estradiol; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mice; Neoplasms; NF-kappa B; Topotecan; Transcription Factors; Tumor Cells, Cultured | 2011 |
HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Anthracyclines; Biphenyl Compounds; Cardiac Glycosides; Humans; Hypoxia-Inducible Factor 1; Indazoles; Lignans; Models, Biological; Neoplasms; Neovascularization, Pathologic; Retinal Neovascularization; Vascular Endothelial Growth Factors | 2016 |
Stimulators and activators of soluble guanylate cyclase for urogenital disorders.
Topics: Aging; Animals; Benzoates; Diabetes Complications; Enzyme Activators; Humans; Hypertension; Indazoles; Lower Urinary Tract Symptoms; Nitric Oxide; Obesity; Phosphodiesterase 5 Inhibitors; Pyrazoles; Pyridines; Reactive Oxygen Species; Risk Factors; Soluble Guanylyl Cyclase; Urinary Tract | 2018 |
Advances in antitumor research of HIF-1α inhibitor YC-1 and its derivatives.
Topics: Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; RNA, Messenger | 2023 |
2 trial(s) available for indazoles and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
| Article | Year |
|---|---|
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.
Topics: Actins; Adipose Tissue; Animals; Collagen; Enzyme Activators; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Obese; Propionates; Receptors, Lysophosphatidic Acid; Tissue Culture Techniques; Transforming Growth Factor beta | 2014 |
HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells.
Topics: Animals; CD4 Antigens; Cytokines; Enzyme Activators; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Interleukin-2 Receptor alpha Subunit; Male; Mice; T-Lymphocytes, Regulatory; Th17 Cells | 2014 |
301 other study(ies) available for indazoles and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
| Article | Year |
|---|---|
YC-1, a novel activator of platelet guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alprostadil; Animals; Bleeding Time; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Methemoglobin; Mice; Molecular Structure; Nitroprusside; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Superoxide Dismutase; Thromboxane A2 | 1994 |
Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.
Topics: Animals; Cell Cycle; Cell Division; Cells, Cultured; Cyclic GMP; Flow Cytometry; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rats | 1995 |
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Guanylate Cyclase; Hemoglobins; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phthalazines; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Solubility; Thrombin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Rabbits; Rats; Rats, Inbred WKY; Superoxides; Vasodilator Agents | 1997 |
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Disease Models, Animal; Enzyme Activation; Fibrinolytic Agents; Fluorescein; Fluoresceins; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Serum Globulins; Solubility; Thrombosis | 1997 |
Inhibition of platelet adhesion to collagen by cGMP-elevating agents.
Topics: Actins; Adult; Blood Platelets; Calcium; Collagen; Cyclic GMP; Humans; Indazoles; Nitroprusside; Platelet Aggregation; Platelet Aggregation Inhibitors | 1997 |
Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle.
Topics: Aldehyde Reductase; Animals; Carotid Arteries; Chalcone; Chalcones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Indazoles; Isoproterenol; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1997 |
Mechanism of YC-1-induced activation of soluble guanylyl cyclase.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Nitrogen Oxides; Photosensitizing Agents; Platelet Aggregation Inhibitors; Protoporphyrins; Solubility | 1998 |
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission | 1998 |
Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.
Topics: Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Histidine; Hydrolysis; Indazoles; Iron; Kinetics; Nitric Oxide | 1998 |
Human soluble guanylate cyclase: functional expression and revised isoenzyme family.
Topics: Amino Acid Sequence; Animals; Cattle; Cyclic GMP; Guanosine Triphosphate; Guanylate Cyclase; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Protein Conformation; Rats; Recombinant Proteins; Solubility; Spodoptera; Vasodilator Agents | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1998 |
Soluble guanylate cyclase: effect of YC-1 on ligation kinetics with carbon monoxide.
Topics: Animals; Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Humans; Indazoles; Kinetics; Ligands; Photolysis; Platelet Aggregation Inhibitors | 1999 |
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide.
Topics: Animals; Baculoviridae; Carbon Monoxide; Cell Line; Copper; Enzyme Activation; Guanylate Cyclase; Heme; Hydrazines; Indazoles; Mass Spectrometry; Nitric Oxide; Nitrogen Oxides; Recombinant Proteins; Spodoptera | 1999 |
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents | 1999 |
Chronic hyperammonemia in rats impairs activation of soluble guanylate cyclase in neurons and in lymphocytes: a putative peripheral marker for neurological alterations.
Topics: Ammonia; Animals; Biomarkers; Cells, Cultured; Chronic Disease; Cyclic GMP; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Indazoles; Lymphocytes; Neurons; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Time Factors | 1999 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation.
Topics: Animals; Aorta; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hemeproteins; Indazoles; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 1999 |
Kinetics and equilibria of soluble guanylate cyclase ligation by CO: effect of YC-1.
Topics: Animals; Carbon Monoxide; Cattle; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Kinetics; Ligands; Models, Chemical; Nitric Oxide; Photolysis; Platelet Aggregation Inhibitors; Solubility; Spectrophotometry, Ultraviolet | 1999 |
YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea.
Topics: Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Nitric Oxide; Superoxides; Trachea | 1999 |
YC-1 potentiates the antiplatelet effect of hydrogen peroxide via sensitization of soluble guanylate cyclase.
Topics: Antioxidants; Blood Platelets; Catalase; Cyclic GMP; Glucose Oxidase; Glutathione Peroxidase; Guanylate Cyclase; Hemostatics; Humans; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Mannitol; Platelet Aggregation Inhibitors; Superoxide Dismutase; Thrombin | 1999 |
Involvement of K(+) channels in the relaxant effects of YC-1 in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; Dose-Response Relationship, Drug; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Indazoles; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilation | 1999 |
Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Homeostasis; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Purinones; Spermine | 1999 |
A point-mutated guanylyl cyclase with features of the YC-1-stimulated enzyme: implications for the YC-1 binding site?
Topics: Animals; Binding Sites; Catalytic Domain; Cattle; Conserved Sequence; Cyclic GMP; Dimerization; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Magnesium; Manganese; Mutagenesis, Site-Directed; Nitric Oxide; Point Mutation; Solubility | 1999 |
Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase.
Topics: Animals; Aorta, Thoracic; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Ionophores; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Rats; Rats, Wistar; Solubility; Time Factors | 1999 |
Novel strategies for opposing murine microglial activation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dipyridamole; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Imidazoles; Indazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha | 2000 |
Rate of deactivation of nitric oxide-stimulated soluble guanylate cyclase: influence of nitric oxide scavengers and calcium.
Topics: Animals; Calcium; Cattle; Cytosol; Dithiothreitol; Enzyme Activation; Enzyme Activators; Enzyme Stability; Free Radical Scavengers; Glutathione; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Nitric Oxide; Oxyhemoglobins; Reducing Agents; Solubility; Substrate Specificity | 2000 |
The vasodilator-stimulated phosphoprotein (VASP): target of YC-1 and nitric oxide effects in human and rat platelets.
Topics: Animals; Cell Adhesion Molecules; Electrophoresis, Polyacrylamide Gel; Guanosine Monophosphate; Guanylate Cyclase; Humans; Indazoles; Male; Microfilament Proteins; Nitric Oxide; Nitroprusside; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Second Messenger Systems; Vasodilator Agents | 2000 |
Interaction of soluble guanylate cyclase with YC-1: kinetic and resonance Raman studies.
Topics: Animals; Escherichia coli; Guanylate Cyclase; Indazoles; Kinetics; Protein Binding; Spectrum Analysis, Raman | 2000 |
Potentiation of carbon monoxide-induced relaxation of rat aorta by YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole].
Topics: Animals; Aorta, Thoracic; Carbon Monoxide; Drug Synergism; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 2000 |
Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Hypertension; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Inbred WKY | 2000 |
The mechanism of actions of 3-(5'-(hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on Ca(2+)-activated K(+) currents in GH(3) lactotrophs.
Topics: Animals; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Electric Stimulation; Indazoles; Membrane Potentials; Potassium Channels; Time Factors; Tumor Cells, Cultured | 2000 |
YC-1, an activation inductor of soluble guanylyl cyclase.
Topics: Crystallography, X-Ray; Enzyme Activators; Guanylate Cyclase; Hydrogen Bonding; Indazoles; Models, Molecular; Molecular Conformation | 2000 |
YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formation.
Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cyclic GMP; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Recurrence; RNA, Messenger; Transcription, Genetic; Tunica Intima | 2000 |
Molecular mechanisms involved in the synergistic activation of soluble guanylyl cyclase by YC-1 and nitric oxide in endothelial cells.
Topics: Animals; Cells, Cultured; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Swine | 2001 |
YC-1 enhances the responsiveness of tolerant vascular smooth muscle to glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; Enzyme Activators; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Rabbits; Vasodilator Agents | 2001 |
NO-independent regulatory site on soluble guanylate cyclase.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxides; Cysteine; Disease Models, Animal; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Imidazoles; In Vitro Techniques; Indazoles; Molecular Sequence Data; Nitric Oxide; Photoaffinity Labels; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Rats; Solubility | 2001 |
Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Drug Interactions; Electrophysiology; Enzyme Activators; Indazoles; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; PC12 Cells; Pheochromocytoma; Pituitary Gland; Potassium Channels; Potassium Channels, Calcium-Activated; Rats; Tumor Cells, Cultured; Vinca Alkaloids | 2001 |
NO-independent stimulators of soluble guanylate cyclase.
Topics: Animals; Aorta; Enzyme Activators; Guanylate Cyclase; Indazoles; Pyrazoles; Pyridines; Rabbits; Structure-Activity Relationship; Vasodilation | 2001 |
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.
Topics: Cell Hypoxia; Cyclic GMP; DNA-Binding Proteins; Drug Interactions; Endothelial Growth Factors; Enzyme Activators; Erythropoietin; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lymphokines; Nuclear Proteins; Oxygen; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin | 2001 |
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission | 2001 |
In vitro activation of soluble guanylyl cyclase and nitric oxide release: a comparison of NO donors and NO mimetics.
Topics: Animals; Aorta; Cysteine; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Hydrazines; Indazoles; Molecular Mimicry; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroso Compounds; Penicillamine; Rats; S-Nitrosoglutathione; Solubility | 2001 |
Inhibition of glucose transport by cyclic GMP in cardiomyocytes.
Topics: Animals; Biological Transport; Cell Hypoxia; Cell Membrane Permeability; Cells, Cultured; Cyclic GMP; Deoxyglucose; Drug Combinations; Female; Glucose Transporter Type 4; Glycolysis; Hydrogen Peroxide; Indazoles; Insulin; Microscopy, Confocal; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Oligomycins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Rotenone | 2001 |
Inhibition of extracellular Ca(2+) entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils.
Topics: Animals; Calcium; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Indazoles; Ion Transport; Manganese; Neutrophils; Phosphorylation; Platelet Aggregation Inhibitors; Rats; Solubility; Tyrosine | 2001 |
Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Cytoplasmic and Nuclear; Receptors, Thrombin; Soluble Guanylyl Cyclase; Structure-Activity Relationship | 2001 |
Organic phosphates as a new class of soluble guanylate cyclase inhibitors.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Animals; Binding, Competitive; Carbon Monoxide; Cattle; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Organophosphorus Compounds; Penicillamine; Phytic Acid; Signal Transduction; Solubility | 2001 |
Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism.
Topics: Adrenal Medulla; Animals; Apoptosis; Cattle; Cell Adhesion; Cell Size; Cells, Cultured; Chromaffin Cells; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium; Enzyme Activators; Indazoles; Intracellular Fluid; Time Factors | 2001 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase.
Topics: Acrylamide; Circular Dichroism; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Models, Chemical; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Protein Conformation; Protein Structure, Secondary; Spectrometry, Fluorescence; Tryptophan | 2001 |
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition.
Topics: Animals; Axons; Cyclic GMP; Drug Interactions; Enzyme Activators; Glucose; Guanylate Cyclase; Indazoles; Male; Nitric Oxide; Oxygen; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels | 2002 |
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272.
Topics: Animals; Cells, Cultured; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Indazoles; Insecta; Nitric Oxide; Photoaffinity Labels; Pyrazoles; Pyridines; Recombinant Proteins | 2001 |
Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP.
Topics: Animals; Arginine; Cyclic GMP; Female; Indazoles; Intraocular Pressure; Male; Nitric Oxide Donors; Nitric Oxide Synthase; Purinones; Rabbits | 2002 |
YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.
Topics: Angioplasty, Balloon; Animals; Arterial Occlusive Diseases; Blood Platelets; Carotid Stenosis; Cell Adhesion; Cell Division; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Hydrogels; Indazoles; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Polyethylene Glycols; Rats; Rats, Sprague-Dawley | 2002 |
Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1.
Topics: Animals; Carbon Monoxide; Electric Stimulation; Enzyme Activators; Female; Indazoles; Muscle Relaxation; Nitric Oxide; Swine; Urethra | 2002 |
Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dogs; Guanylate Cyclase; Indazoles; Insulin; Isocitrates; Lactic Acid; Muscle, Smooth, Vascular; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxaloacetic Acid; Oxidation-Reduction; Pyruvic Acid; Stimulation, Chemical | 2002 |
BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase.
Topics: Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Humans; Hydrazines; Indazoles; Isoenzymes; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Protein Subunits; Pyrazoles; Pyridines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spodoptera | 2002 |
Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Hydrostatic Pressure; Indazoles; Injections; Injections, Intraperitoneal; Male; Nitric Oxide; Penile Erection; Penis; Rats | 2002 |
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Topics: Animals; Cerebellum; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2002 |
Inhibition of deactivation of NO-sensitive guanylyl cyclase accounts for the sensitizing effect of YC-1.
Topics: Animals; Cattle; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Humans; Indazoles; Kinetics; Mutagenesis, Site-Directed; Nitric Oxide | 2002 |
Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1.
Topics: Animals; Cell Line; Cloning, Molecular; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Isoenzymes; Male; Muscle, Smooth; Nitric Oxide; Penis; Rabbits; Rats; Recombinant Proteins | 2002 |
Inhibition of superoxide anion generation by YC-1 in rat neutrophils through cyclic GMP-dependent and -independent mechanisms.
Topics: Animals; Calcium; Cell-Free System; Cyclic GMP; Enzyme Activators; In Vitro Techniques; Indazoles; Mitogen-Activated Protein Kinases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphorylation; Protein Kinase C; Rats; Respiratory Burst; Superoxides | 2002 |
YC-1 increases cyclo-oxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells.
Topics: Analysis of Variance; Blotting, Western; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Enzyme Activators; Enzyme Induction; Humans; Indazoles; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tumor Cells, Cultured | 2002 |
Selective regulation of blood pressure by heme oxygenase-1 in hypertension.
Topics: Animals; Blood Pressure; Culture Techniques; Cyclic GMP; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hypertension; Indazoles; Male; Mesenteric Arteries; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 2002 |
1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.
Topics: Administration, Oral; Animals; Apoptosis; Cells, Cultured; Enzyme Activators; Indazoles; Mice; Muscle Cells; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Rats; Sepsis | 2002 |
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction | 2002 |
Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta.
Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Aorta; Base Sequence; Blotting, Northern; Blotting, Western; Cell Nucleus; Cells, Cultured; Dactinomycin; Down-Regulation; ELAV Proteins; ELAV-Like Protein 1; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Molecular Sequence Data; Muscle, Smooth; Nucleic Acid Synthesis Inhibitors; Oxadiazoles; Oxazines; Poly A; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Soluble Guanylyl Cyclase; Time Factors; Transcription, Genetic; Transfection | 2003 |
A-350619: a novel activator of soluble guanylyl cyclase.
Topics: Acrylamides; Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Penile Erection; Rabbits; Rats; Rats, Wistar; Spodoptera | 2003 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
YC-1 facilitates release of the proximal His residue in the NO and CO complexes of soluble guanylate cyclase.
Topics: Animals; Carbon Monoxide; Cattle; Electron Spin Resonance Spectroscopy; Guanylate Cyclase; Histidine; Indazoles; Nitric Oxide | 2003 |
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.
Topics: Animals; Cattle; Cell Line; Cloning, Molecular; Enzyme Activation; Enzyme Activators; Gene Deletion; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera | 2003 |
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Indazoles; Isoindoles; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Organoselenium Compounds; Papaverine; Penicillamine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Vasodilation | 2003 |
Is HIF-1 alpha a valid therapeutic target?
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Disease Models, Animal; Endothelial Growth Factors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Neoplasms; Neovascularization, Pathologic; Repressor Proteins; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell Hypoxia; Culture Media, Conditioned; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Female; G(M1) Ganglioside; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indazoles; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Killer Cells, Natural; Liver Neoplasms; Lymphokines; Male; Mice; Mice, SCID; Neoplasms; Neovascularization, Pathologic; Neuroblastoma; Platelet Endothelial Cell Adhesion Molecule-1; Precipitin Tests; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Transcription Factors; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole.
Topics: Animals; Electrophysiology; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Immunohistochemistry; Indazoles; Long-Term Potentiation; Male; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Wistar; Synaptic Transmission | 2003 |
Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Macrophages, Alveolar; Rats; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2003 |
YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway.
Topics: Cell Division; Cyclic GMP; DNA; Endothelium, Vascular; G1 Phase; Humans; Indazoles; Platelet Aggregation Inhibitors; Resting Phase, Cell Cycle; Thymidine; Tritium | 2003 |
Preparation of heme-free soluble guanylate cyclase.
Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc | 2003 |
Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway.
Topics: Adolescent; Adult; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Humans; Indazoles; Neutrophils; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Superoxides | 2003 |
Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat.
Topics: Aminoquinolines; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Feedback; Hippocampus; Indazoles; Male; Microinjections; Nitric Oxide; Penile Erection; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Venous Pressure | 2004 |
Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.
Topics: Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Colon; DNA-Binding Proteins; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Humans; Immediate-Early Proteins; Immunoblotting; Immunohistochemistry; Indazoles; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intramolecular Oxidoreductases; Luciferases; Microsomes; Models, Biological; Nitric Oxide; Oligonucleotides, Antisense; Plasmids; Promoter Regions, Genetic; Prostaglandin-E Synthases; Protein Kinase C; RNA Interference; Signal Transduction; Transcription Factors; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2004 |
YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cytochromes c; Depression, Chemical; Enzyme Activation; Gene Expression; Genes, bcl-2; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Atrial Natriuretic Factor; Vasodilator Agents | 2004 |
The NO signaling pathway differentially regulates KCC3a and KCC3b mRNA expression.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Soluble Guanylyl Cyclase; Symporters; Thionucleotides | 2003 |
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activators; Female; Glyburide; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isometric Contraction; Methylene Blue; Nitric Oxide; Potassium Channel Blockers; Pregnancy; Rats; Rats, Wistar; Solubility; Tetraethylammonium; Uterine Contraction | 2004 |
Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinase Type II; Cyclic GMP-Dependent Protein Kinases; Dactinomycin; Guanylate Cyclase; Indazoles; Insulin; Insulin Secretion; Islets of Langerhans; Protein Isoforms; Rats; Signal Transduction; Thionucleotides; Transcription, Genetic | 2004 |
Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Humans; Indazoles; Interleukin-1; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroso Compounds; Nucleotides, Cyclic; Oxadiazoles; Quinoxalines; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2004 |
Inhibitory mechanisms of YC-1 and PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages.
Topics: Animals; Chromans; Drug Interactions; Enzyme Activation; Gene Expression; Indazoles; Lipopolysaccharides; Macrophages; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; RNA, Messenger; Shock, Septic; Teichoic Acids | 2004 |
Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site?
Topics: Amino Acid Sequence; Animals; Asparagine; Binding Sites; COS Cells; Cyclic GMP; Cysteine; Cytosol; DNA Mutational Analysis; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Kinetics; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide; Phenotype; Protein Subunits; Pyrazoles; Pyridines; Rats; Solubility; Tyrosine | 2004 |
The inhibitory mechanism of YC-1, a benzyl indazole, on smooth muscle cell proliferation: an in vitro and in vivo study.
Topics: Administration, Topical; Animals; Aorta, Thoracic; Carotid Artery, Common; Catheterization; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanylate Cyclase; Imidazoles; Indazoles; Muscle, Smooth, Vascular; Poloxamer; Protein-Tyrosine Kinases; Rats; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; RNA, Messenger; Transforming Growth Factor beta; Tunica Intima | 2004 |
Antiaggregating and antithrombotic activities of new 1, 2, 3-triazolecarboxamides.
Topics: Animals; Fibrinolytic Agents; Guanylate Cyclase; Indazoles; Lasers; Phosphoric Diester Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Triazoles | 2004 |
Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Humans; Indazoles; Kidney; Nitric Oxide; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Quaternary Ammonium Compounds; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; S-Nitrosoglutathione; Soluble Guanylyl Cyclase; Transfection; Vasodilation | 2004 |
Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.
Topics: Animals; Cattle; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Imidazoles; In Vitro Techniques; Indazoles; Solubility; Spectrum Analysis, Raman | 2004 |
cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arterioles; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activators; Hydrolysis; Indazoles; Male; Multidrug Resistance-Associated Proteins; Nitric Oxide; Nitric Oxide Donors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Vasodilation | 2004 |
Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland.
Topics: Amylases; Animals; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Muscarinic Agonists; Nitric Oxide; Nitric Oxide Donors; Parotid Gland; Rats; Rats, Wistar; S-Nitrosoglutathione; Signal Transduction | 2004 |
YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.
Topics: Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; I-kappa B Proteins; Indazoles; Interleukin-1; Isoenzymes; Lung; Membrane Proteins; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Polyenes; Polyunsaturated Alkamides; Proline; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Thiocarbamates; Transcription Factors | 2004 |
An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain.
Topics: Amino Acid Sequence; Animals; Brain; Conserved Sequence; Cyclic GMP; Evolution, Molecular; Female; Grasshoppers; Guanylate Cyclase; Indazoles; Insect Proteins; Male; Molecular Sequence Data; Nitric Oxide; Periplaneta; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Up-Regulation | 2004 |
Soluble guanylyl cyclase during postnatal porcine pulmonary maturation.
Topics: Aging; Animals; Animals, Newborn; Base Sequence; Cyclic GMP; Enzyme Activators; Guanylate Cyclase; Indazoles; Molecular Sequence Data; Nitric Oxide; Pulmonary Artery; RNA, Messenger; Sequence Homology, Nucleic Acid; Solubility; Swine; Vasodilation | 2005 |
Activation of soluble guanylyl cyclase inhibits estradiol production and cyclic AMP accumulation from cultured rat granulosa cells.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Drug Synergism; Enzyme Activation; Enzyme Activators; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Guanylate Cyclase; Hormones; Immunoblotting; Indazoles; Isoenzymes; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Solubility | 2004 |
The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.
Topics: Actins; Adenosine Triphosphate; Amidines; Animals; Aristolochic Acids; Barium; Benzylamines; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Drug Interactions; Enzyme Inhibitors; Indazoles; Indoles; Interleukin-8; Membrane Potentials; Mitochondria; Neutrophils; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sodium; Sphingosine | 2004 |
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Proliferation; Cyclic GMP; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; G1 Phase; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; Transcription Factors; Tumor Suppressor Proteins | 2005 |
CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule.
Topics: Animals; Aorta; Blood; Boranes; Carbon Monoxide; Carbonates; Carboxyhemoglobin; Humans; Hydrogen-Ion Concentration; Indazoles; Male; Organometallic Compounds; Pharmaceutical Preparations; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Temperature; Vasodilator Agents | 2005 |
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta.
Topics: Acetylcholine; Animals; beta-Cyclodextrins; Caveolae; Caveolin 1; Caveolins; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Immunohistochemistry; In Vitro Techniques; Indazoles; Isometric Contraction; Male; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasodilator Agents | 2005 |
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Blotting, Western; Cell Movement; Cell Proliferation; Endothelial Cells; Endothelium, Vascular; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Guanylate Cyclase; Humans; Indazoles; Longevity; Microtubules; Neoplasms; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Tetrazolium Salts; Thiazoles; Thymidine; Vascular Endothelial Growth Factor A | 2005 |
Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.
Topics: Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Protein Conformation; Pyrazoles; Pyridines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Structure-Activity Relationship | 2005 |
The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes.
Topics: Animals; Binding, Competitive; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Myocytes, Cardiac; Nitric Oxide Donors; Nitroprusside; Potassium; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Sodium; Sodium-Potassium-Exchanging ATPase; Soluble Guanylyl Cyclase | 2005 |
Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1.
Topics: Animals; Enzyme Activators; Excitatory Postsynaptic Potentials; Guanylate Cyclase; Indazoles; Learning; Nitric Oxide; Nootropic Agents; Rats; Rats, Wistar; Reaction Time | 2005 |
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models.
Topics: Animals; Blotting, Western; Cyclic GMP; Cytokines; Disease Models, Animal; DNA; Endotoxemia; Humans; Immunohistochemistry; Indazoles; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Shock, Septic; Time Factors; Up-Regulation | 2005 |
Nitric oxide/cyclic guanosine monophosphate signaling in the central complex of the grasshopper brain inhibits singing behavior.
Topics: Animals; Behavior, Animal; Brain; Cyclic GMP; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Functional Laterality; Grasshoppers; Immunohistochemistry; Indazoles; Male; Muscarine; Muscarinic Agonists; Muscle, Smooth, Vascular; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Signal Transduction; Time Factors; Vocalization, Animal | 2005 |
YC-1-inhibited proliferation of rat mesangial cells through suppression of cyclin D1-independent of cGMP pathway and partially reversed by p38 MAPK inhibitor.
Topics: Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; Gene Expression; Glomerular Mesangium; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanylate Cyclase; Imidazoles; Indazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Rats; RNA, Messenger; Signal Transduction; Solubility; Tumor Suppressor Proteins | 2005 |
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indazoles; Male; Methylene Blue; Muscle Relaxation; Myometrium; Nitric Oxide Donors; Pregnancy; Rats; Rats, Wistar; Time Factors; Triazenes; Uterine Contraction | 2005 |
Enhanced responsiveness to nitric oxide, nitroxyl anions, and nitrergic transmitter by 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole in the rat anococcygeus muscle.
Topics: Animals; Electric Stimulation; Indazoles; Male; Muscle Relaxation; Muscle, Skeletal; Neurotransmitter Agents; Nitrergic Neurons; Nitric Oxide; Nitrogen Oxides; Rats; Rats, Sprague-Dawley | 2005 |
New drugs target hypoxia response in tumors.
Topics: Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; DNA-Binding Proteins; Drugs, Investigational; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mustard Compounds; Neoplasms; Neovascularization, Pathologic; Nuclear Proteins; Phenylpropionates; Topotecan; Transcription Factors; Transplantation, Heterologous | 2005 |
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors | 2005 |
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia.
Topics: Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphate Isomerase; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Phosphatidylinositol 3-Kinases; Signal Transduction; Vascular Endothelial Growth Factor A | 2005 |
Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; Heart Rate; Hypertension; In Vitro Techniques; Indazoles; Male; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phenylephrine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.
Topics: Angiogenesis Inhibitors; Animals; Carotid Arteries; Catheterization; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Immunohistochemistry; Indazoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Humans; I-kappa B Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Indazoles; Male; Mice; Mice, SCID; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Prostatic Neoplasms; Transcription Factor RelA; Xenograft Model Antitumor Assays | 2005 |
The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.
Topics: Drug Design; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Indazoles; Molecular Structure; Platelet Aggregation Inhibitors; Solubility; Tritium | 2006 |
Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Mesenteric Artery, Superior; Nitric Oxide; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Vasodilation | 2006 |
BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH cells.
Topics: Action Potentials; Algorithms; Animals; Calcium; Calcium Channels, L-Type; Cell Line; Cell Line, Tumor; Electrophysiology; Enzyme Activators; Fluorometry; Guanylate Cyclase; Humans; Indazoles; Neurons; Neurosecretory Systems; Nitric Oxide; Patch-Clamp Techniques; Pituitary Gland; Potassium Channels, Calcium-Activated; Pyrazoles; Pyridines; Rats | 2005 |
Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries.
Topics: Animals; Animals, Newborn; Enzyme Activators; Guanylate Cyclase-Activating Proteins; Indazoles; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Platelet Aggregation Inhibitors; Pulmonary Artery; Swine; Vasodilation | 2006 |
Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi.
Topics: Animals; Cyclic GMP; Hydrazines; In Vitro Techniques; Indazoles; Male; Muscle Relaxation; Neuromuscular Blocking Agents; Nitrogen Oxides; Sheep; Sphincter of Oddi | 2006 |
YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX.
Topics: Blood Platelets; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Humans; Indazoles; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protoporphyrins | 2006 |
Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Butadienes; Colonic Neoplasms; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Activators; Humans; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Sulindac; Tumor Cells, Cultured | 2006 |
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
Topics: Analysis of Variance; Blood Platelets; Carbon Monoxide; Collagen; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide Donors; Organometallic Compounds; Oxadiazoles; Penicillamine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Spectrophotometry; Statistics, Nonparametric; Thrombin; Time Factors | 2006 |
A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent.
Topics: Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression; Green Fluorescent Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mutation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Transfection | 2006 |
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Checkpoint Kinase 1; Checkpoint Kinase 2; Enzyme Activation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; S Phase | 2006 |
Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Proto-Oncogene Proteins c-mdm2 | 2006 |
Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Etoposide; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Vincristine | 2006 |
[Inhibitory effect of YC-1 on induction of VEGF and GPI genes in hypoxic human pancreatic cancer cells].
Topics: Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Enzyme Activators; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphate Isomerase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Vascular Endothelial Growth Factors | 2006 |
Contractile performance of adult ventricular rat cardiomyocytes is not directly jeopardized by NO/cGMP-dependent induction of pro-apoptotic pathways.
Topics: Animals; Apoptosis; Caspase 3; Cell Movement; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Indazoles; Male; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2007 |
Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Granulocytes; HL-60 Cells; Humans; Indazoles; Leukemia; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrazoles | 2007 |
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; I-kappa B Kinase; Indazoles; Male; Mitogens; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases | 2007 |
Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells.
Topics: Apoptosis; Cell Division; Cell Hypoxia; Cell Line, Tumor; Enzyme Activators; Gene Expression Regulation, Neoplastic; Glucose-6-Phosphate Isomerase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Oxygen; Pancreatic Neoplasms; RNA, Messenger; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2007 |
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines | 2007 |
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides | 2007 |
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.
Topics: Animals; Bone Neoplasms; Breast Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Inbred C3H; Mice, Nude; Recombinant Fusion Proteins; Transfection | 2007 |
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Drug Screening Assays, Antitumor; Green Fluorescent Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Laminin; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Proteoglycans | 2007 |
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression.
Topics: Animals; Blood-Brain Barrier; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ischemia; Male; Membrane Proteins; Permeability; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2007 |
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Bucladesine; Calcium; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Microfilament Proteins; Nucleotides, Cyclic; Oligopeptides; Peptide Fragments; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thionucleotides; Thrombin | 2007 |
Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Topics: Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indazoles; Kidney Transplantation; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Organ Preservation; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Retrospective Studies; Vasodilation; Vasodilator Agents | 2007 |
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Topics: Alcohols; Chemistry, Pharmaceutical; Drug Design; Electrons; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Indazoles; Kinetics; Models, Chemical; Nitric Oxide; Organophosphonates; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Temperature | 2007 |
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation | 2007 |
Modulation of human monocyte-derived dendritic cells maturation by a soluble guanylate cyclase activator, YC-1, in a cyclic nucleotide independent manner.
Topics: Cell Differentiation; Cell Proliferation; Cyclic AMP; Cyclic GMP; Dendritic Cells; Guanylate Cyclase; Humans; Immunologic Factors; Indazoles; Interleukin-10; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Receptors, CCR7; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; T-Lymphocytes | 2007 |
Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice.
Topics: Animals; Apoptosis; Blotting, Western; Electrophoresis, Agar Gel; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Indazoles; Leukemia, Experimental; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; U937 Cells | 2007 |
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; G1 Phase; Humans; Indazoles; Lung Neoplasms; Mitogen-Activated Protein Kinases; Neoplasm Metastasis | 2008 |
YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity.
Topics: Adenosine; Adult; Cell Aggregation; Complement C5a; Cyclic AMP; Enzyme Activators; Humans; In Vitro Techniques; Indazoles; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 2008 |
Inhibitory effect of YC-1, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole, on experimental choroidal neovascularization in rat.
Topics: Angiogenesis Inhibitors; Animals; Choroidal Neovascularization; Female; Fluorescein Angiography; Fluorescent Antibody Technique; Fundus Oculi; Hypoxia-Inducible Factor 1; Indazoles; Laser Coagulation; Rats; Rats, Inbred BN; Staining and Labeling; Vascular Endothelial Growth Factor A | 2008 |
Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspase 9; Cell Line, Tumor; Cisplatin; Cyclin D; Cyclins; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Microtubule-Associated Proteins; Neoplasm Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; STAT3 Transcription Factor; Survivin; Ubiquitination; Xenograft Model Antitumor Assays | 2007 |
SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Benzoquinones; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lactams, Macrocyclic; Neoplasm Proteins; Paclitaxel; Protein Isoforms; Recombinant Fusion Proteins; RNA Interference; RNA, Messenger; RNA, Neoplasm; Septins; Transcription, Genetic; Tubulin Modulators | 2007 |
YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.
Topics: Animals; Apoptosis; Cell Nucleus; DNA-Binding Proteins; Enzyme Activators; Flow Cytometry; Gene Expression Regulation; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Indazoles; Lipoproteins, LDL; Male; Models, Biological; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Transcription Factors | 2008 |
ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha.
Topics: Animals; Atrial Natriuretic Factor; Calcium; Cell Membrane; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Hepatocytes; Indazoles; Male; Nitroprusside; Rats; Rats, Wistar; Thionucleotides | 2008 |
An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Allosteric Regulation; Animals; Cattle; Cyclic GMP; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Indazoles; Kinetics; Lung; Models, Chemical; Nitric Oxide; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrophosphatases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Thermodynamics | 2008 |
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Enhancement of active shuttle avoidance response by the NO-cGMP-PKG activator YC-1.
Topics: Amygdala; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Indazoles; Long-Term Potentiation; Male; MAP Kinase Signaling System; Nitric Oxide; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger | 2008 |
YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.
Topics: Animals; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Caspase 8; Chromatin; Dose-Response Relationship, Drug; Enzyme Activators; Fas Ligand Protein; fas Receptor; G1 Phase; Humans; Indazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation | 2008 |
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
Topics: Aging; Animals; Disease Models, Animal; Enzyme Activators; Epithelial Cells; Female; Fibrosis; Gene Deletion; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Transfection; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein | 2008 |
YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Enzyme Activators; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Indazoles; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type II; Rats; RNA, Messenger | 2009 |
Binding of YC-1 or BAY 41-2272 to soluble guanylyl cyclase induces a geminate phase in CO photolysis.
Topics: Carbon Monoxide; Guanylate Cyclase; Indazoles; Photolysis; Protein Binding; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Time Factors | 2008 |
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
Topics: Amino Acids, Dicarboxylic; Cell Line, Tumor; Enzyme Activators; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mixed Function Oxygenases; Models, Biological; p300-CBP Transcription Factors; Plasmids; Protein Biosynthesis; Repressor Proteins; RNA, Small Interfering; Transcriptional Activation | 2008 |
Thrombin up-regulates vascular endothelial growth factor in experimental gliomas.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Glioma; Hemostatics; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Rats; Rats, Inbred F344; Signal Transduction; Thrombin; Time Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy.
Topics: Animals; Cell Hypoxia; Furans; HeLa Cells; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mice; Mice, SCID; Neoplasms; Oxygen Consumption; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2009 |
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork | 2009 |
Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs.
Topics: Amrinone; Animals; Arginine; Bile Ducts; Cyclic GMP; Gallbladder; Guanidines; Guinea Pigs; Hydrazines; In Vitro Techniques; Indazoles; Ligation; Male; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Papaverine; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2009 |
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects.
Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Proliferation; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley | 2009 |
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
Topics: Animals; Calcium Channels, L-Type; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Activation; Guanylate Cyclase; Indazoles; Ion Channel Gating; Isoproterenol; Mice; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Purinones; Receptors, Adrenergic, beta; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2009 |
[Effect of YC-1 on HIF-1 alpha and VEGF expression in human hepatocarcinoma cell lines].
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factors | 2009 |
Using YC-1 to overcome the radioresistance of hypoxic cancer cells.
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Indazoles; Laryngeal Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Treatment Outcome | 2009 |
Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; DNA Damage; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Female; Guanylate Cyclase; Humans; Indazoles; Neoplasm Proteins; Ovarian Neoplasms | 2009 |
Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis.
Topics: Active Transport, Cell Nucleus; Angiogenesis Inhibitors; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Erythropoietin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Microvessels; Neovascularization, Physiologic; Platelet Endothelial Cell Adhesion Molecule-1; Proteasome Endopeptidase Complex; Retinal Vessels; RNA, Messenger; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2009 |
Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation.
Topics: Animals; Calcium Channel Blockers; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Indazoles; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stereoisomerism; Urethra | 2009 |
Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Enzyme Activators; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; Indazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Proto-Oncogene Proteins c-raf; Pulmonary Alveoli; ras Proteins; Signal Transduction | 2009 |
Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
Topics: Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Checkpoint Kinase 2; Down-Regulation; Furans; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Proteins; Poly(ADP-ribose) Polymerases; Protein Array Analysis; Protein Kinases; Protein Serine-Threonine Kinases; S Phase | 2010 |
The effect of heme oxygenase inhibition on visual evoked potentials.
Topics: Animals; Arsenites; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Evoked Potentials, Visual; Heme Oxygenase (Decyclizing); Indazoles; Male; Metalloporphyrins; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Compounds; Visual Pathways | 2009 |
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Indazoles; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxygen; Retinal Diseases; Retinal Neovascularization | 2010 |
The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
Topics: Animals; Coronary Vessels; Enzyme Activation; Enzyme Activators; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits | 2010 |
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells.
Topics: Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Fetal Blood; Flow Cytometry; Hematopoietic Stem Cells; Humans; Imidazoles; Indazoles; Killer Cells, Natural; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-15; Signal Transduction; STAT5 Transcription Factor | 2010 |
[Effects of hypoxia-inducible factor inhibitor on expression of HIF-1alpha and VEGF and induction of apoptosis in leukemic cell lines].
Topics: Apoptosis; Cell Hypoxia; Gene Expression Regulation, Leukemic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Jurkat Cells; K562 Cells; U937 Cells; Vascular Endothelial Growth Factor A | 2010 |
Development of nitrergic neurons in the nervous system of the locust embryo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Citrulline; Cyclic GMP; Embryo, Nonmammalian; Enzyme Activators; Ganglia, Invertebrate; Indazoles; Locusta migratoria; NADPH Dehydrogenase; Nerve Regeneration; Nervous System; Neurites; Neurons; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Signal Transduction | 2010 |
Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Cycloheximide; Cytoprotection; Deferoxamine; Drug Interactions; Enzyme Inhibitors; Hydrogen Peroxide; Hydroxybenzoates; Hypoxia-Inducible Factor 1; Indazoles; Mice; Oxidative Stress; Signal Transduction; Vascular Endothelial Growth Factor A | 2010 |
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.
Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Disease Models, Animal; Estradiol; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2010 |
Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
Topics: Animals; Binding Sites; Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrum Analysis, Raman | 2010 |
Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.
Topics: Allosteric Regulation; Animals; Crystallography, X-Ray; Enzyme Activators; Guanylate Cyclase; Indazoles; Nitric Oxide; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2010 |
Insulin promotes proliferative vitality and invasive capability of pancreatic cancer cells via hypoxia-inducible factor 1alpha pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Insulin; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Signal Transduction | 2010 |
Efficient two-step sequence for the synthesis of 2,5-disubstituted furan derivatives from functionalized nitroalkanes: successive Amberlyst A21- and Amberlyst 15-catalyzed processes.
Topics: Alkanes; Catalysis; Furans; Indazoles; Molecular Structure; Nitro Compounds; Styrenes | 2010 |
YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Humans; Indazoles; Nitric Oxide; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; Signal Transduction | 2011 |
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts.
Topics: Animals; Aorta, Abdominal; Apoptosis; Carbon Monoxide; Endothelial Cells; Graft Occlusion, Vascular; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Intercellular Adhesion Molecule-1; Isotonic Solutions; Male; Rats; Rats, Inbred Lew; Ringer's Lactate; Time Factors; Tissue and Organ Harvesting; Tissue Preservation; Tunica Intima; Vascular Endothelial Growth Factor A; Vascular Grafting; Vena Cava, Inferior | 2011 |
Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Up-Regulation | 2011 |
Involvement of YC-1 in extracellular signal-regulated kinase action in rat cremasteric muscle.
Topics: Animals; Capillaries; Extracellular Signal-Regulated MAP Kinases; Guanylate Cyclase; Indazoles; Leukocytes; Male; Microcirculation; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; Signal Transduction; Soluble Guanylyl Cyclase; Venules | 2010 |
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling | 2011 |
Hypoxia-inducible factor-1α is essential for hypoxia-induced mesenchymal stem cell mobilization into the peripheral blood.
Topics: Animals; Blood Cells; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CXCL12; Colony-Forming Units Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophenotyping; Indazoles; Male; Mesenchymal Stem Cells; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2011 |
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Topics: Animals; Carotid Body; Central Nervous System; Deferoxamine; Digoxin; Enzyme Inhibitors; Fibroblasts; Furans; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NADPH Oxidase 2; NADPH Oxidases; PC12 Cells; Peripheral Nervous System; Rats; Reactive Oxygen Species; Siderophores; Sleep Apnea Syndromes | 2011 |
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine.
Topics: Analgesics, Opioid; Animals; Cyclic GMP; Drug Tolerance; Guanylate Cyclase; Indazoles; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Soluble Guanylyl Cyclase | 2011 |
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.
Topics: Alanine; Animals; Aspartic Acid; Chlorocebus aethiops; COS Cells; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase | 2011 |
Inhibition of hypoxia inducible factor 1α expression suppresses the progression of esophageal squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Esophageal Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Nude; RNA Interference; Xenograft Model Antitumor Assays | 2011 |
Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.
Topics: Apoptosis; Biomarkers, Tumor; Caspase 8; Cell Line, Tumor; Enzyme Activators; Female; Guanylate Cyclase; Humans; Indazoles; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Neoplasm Proteins; Ovarian Neoplasms; TNF-Related Apoptosis-Inducing Ligand | 2011 |
YC-1 rescues cancer cachexia by affecting lipolysis and adipogenesis.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Antineoplastic Agents; Cachexia; Enzyme Activators; Female; Indazoles; Lipolysis; Mice; Mice, Inbred BALB C; Neoplasms; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
Topics: 2-Methoxyestradiol; Animals; Blood-Brain Barrier; Brain; Endothelial Cells; Estradiol; Glucose; Humans; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Membrane Proteins; Mice; Occludin; Permeability; Phosphoproteins; Tight Junctions; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2012 |
Impact of hypoxia on the metastatic potential of human prostate cancer cells.
Topics: Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Proteins; Prostatic Neoplasms; Time Factors; Tumor Stem Cell Assay | 2011 |
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic | 2011 |
Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy.
Topics: Animals; Blotting, Western; Cell Line; Cell Movement; Cell Proliferation; Cells, Cultured; Fluorescent Antibody Technique; Furans; Glial Fibrillary Acidic Protein; Humans; Hypoxia-Inducible Factor 1; Immunohistochemistry; Indazoles; Mice; Nerve Tissue Proteins; Neuroglia; Oxygen; Proto-Oncogene Proteins c-sis; Retinal Diseases; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.
Topics: Animals; Auditory Threshold; Blotting, Western; Cell Survival; Cobalt; Cochlea; Environmental Exposure; Enzyme Inhibitors; Evoked Potentials, Auditory; Guanylate Cyclase; Hair Cells, Auditory; Hearing; Hearing Loss, Noise-Induced; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Inbred BALB C; Noise | 2011 |
Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction.
Topics: Caco-2 Cells; Epithelium; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Interferon-gamma; Intestines; Membrane Proteins; Myosin Light Chains; Myosin-Light-Chain Kinase; Occludin; Phosphoproteins; Phosphorylation; Tight Junctions; Tumor Necrosis Factor-alpha; Up-Regulation; Zonula Occludens-1 Protein | 2011 |
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea | 2011 |
Activation of PI3 kinase/Akt/HIF-1α pathway contributes to hypoxia-induced epithelial-mesenchymal transition and chemoresistance in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Movement; Cell Survival; Chromones; Cisplatin; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression; Genes, MDR; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Male; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2012 |
Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?
Topics: Aged; Aged, 80 and over; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vasospasm; Endothelium, Vascular; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indazoles; Male; Middle Aged; Radial Artery; Saphenous Vein; Tissue and Organ Harvesting; Vasoconstriction | 2011 |
Mechanisms underlying somatostatin receptor 2 down-regulation of vascular endothelial growth factor expression in response to hypoxia in mouse retinal explants.
Topics: Animals; Cell Hypoxia; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activators; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Inbred C57BL; Octreotide; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Receptors, Somatostatin; Retina; RNA, Small Interfering; STAT3 Transcription Factor; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
YC-1 attenuates hypoxia-induced pulmonary arterial hypertension in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Endothelin-1; Enzyme Activators; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Indazoles; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Pulmonary Artery; Tumor Suppressor Protein p53 | 2011 |
Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Transitional Cell; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Matrix Metalloproteinase 2; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Up-Regulation; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A | 2012 |
Hypoxia inducible factor-1α contributes to UV radiation-induced inflammation, epidermal hyperplasia and immunosuppression in mice.
Topics: Animals; Dermatitis, Contact; Edema; Female; Gene Expression Regulation; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Immune Tolerance; Indazoles; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Skin; T-Lymphocytes; Ultraviolet Rays | 2012 |
HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation.
Topics: Animals; Blotting, Western; CD4 Antigens; Cell Hypoxia; Edema; Female; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Inflammation; Lymph; Lymphangiogenesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C; Wound Healing | 2012 |
Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts.
Topics: Alternative Splicing; Antibodies, Neutralizing; Cell Culture Techniques; Cell Hypoxia; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activators; Escherichia coli; Exons; Fibroblasts; Fluorescent Antibody Technique; Genetic Variation; Gingiva; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunoprecipitation; Indazoles; Lipopolysaccharides; Oxygen Consumption; Time Factors; Toll-Like Receptor 4; Transcription, Genetic; Vascular Endothelial Growth Factor A | 2012 |
Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Neurons; Permeability; Prognosis; Rats; Rats, Sprague-Dawley; Stroke; Survival Rate; Vascular Endothelial Growth Factor A | 2011 |
Hypoxia triggers a HIF-mediated differentiation of peripheral blood mononuclear cells into osteoclasts.
Topics: Acid Phosphatase; Biomarkers; Blotting, Western; Bone Remodeling; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cell Survival; Coculture Techniques; Enzyme-Linked Immunosorbent Assay; Fluoresceins; Fluorescent Dyes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoenzymes; Leukocytes, Mononuclear; Osteoblasts; Osteoclasts; RANK Ligand; Tartrate-Resistant Acid Phosphatase; Up-Regulation; Vascular Endothelial Growth Factor A | 2012 |
YC-1 potentiates cAMP-induced CREB activation and nitric oxide production in alveolar macrophages.
Topics: Animals; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activators; Guanylate Cyclase; Immunoblotting; Indazoles; Isoquinolines; Lung Diseases; Macrophages, Alveolar; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphoric Diester Hydrolases; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides | 2012 |
Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma; Carcinoma, Ovarian Epithelial; Caspases; Cell Line, Tumor; Cell Nucleus; Chalcones; Drug Interactions; Enzyme Activation; Female; Guanylate Cyclase; Humans; Indazoles; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteolysis; Signal Transduction; Tumor Suppressor Protein p53 | 2012 |
Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats.
Topics: Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytoprotection; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Indazoles; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Intestines; Lung; Lung Injury; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Pulmonary Edema; Rats; Rats, Wistar; Shock, Hemorrhagic; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; G1 Phase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Oxygen; RNA, Messenger; STAT3 Transcription Factor; Tumor Burden | 2012 |
Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity.
Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Hypoxia; Cerebral Cortex; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Drug; Enzyme Activators; Estradiol; Excitatory Amino Acids; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; L-Lactate Dehydrogenase; Rats; Rats, Sprague-Dawley | 2012 |
Insufficient radiofrequency ablation promotes angiogenesis of residual hepatocellular carcinoma via HIF-1α/VEGFA.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Carcinoma, Hepatocellular; Catheter Ablation; Cell Survival; Culture Media, Conditioned; Hep G2 Cells; Hot Temperature; Humans; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; Mice; Neovascularization, Pathologic; RNA, Small Interfering; Signal Transduction; Treatment Failure; Vascular Endothelial Growth Factor A | 2012 |
YC-1, a potent antithrombotic agent, induces lipolysis through the PKA pathway in rat visceral fat cells.
Topics: Adipocytes; Animals; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fibrinolytic Agents; Indazoles; Intra-Abdominal Fat; Lipolysis; Male; Rats; Rats, Wistar; Signal Transduction | 2012 |
HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis.
Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Microscopy, Fluorescence; Morpholines; Osteosarcoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA Interference; Sesquiterpenes; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases | 2012 |
YC-1 targeting of hypoxia-inducible factor-1α reduces RGC-5 cell viability and inhibits cell proliferation.
Topics: Antibodies; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ki-67 Antigen; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2012 |
Nitric oxide, can it be only good? Increasing the antioxidant properties of nitric oxide in hepatocytes by YC-1 compound.
Topics: Animals; Antioxidants; Glutathione; Heme Oxygenase-1; Hepatocytes; Humans; Indazoles; Mice; NF-E2-Related Factor 2; Nitric Oxide; Nitroso Compounds; Transforming Growth Factor alpha | 2012 |
Reciprocal regulation of HIF-1α and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Topics: Animals; Apoptosis; Arachidonate 15-Lipoxygenase; Cell Hypoxia; Cell Survival; Cells, Cultured; Feedback, Physiological; Gene Expression Regulation; Hydroxyeicosatetraenoic Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Membrane Potential, Mitochondrial; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction | 2012 |
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells.
Topics: 3' Untranslated Regions; Animals; Apoptosis; Binding Sites; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; MicroRNAs; Neuroblastoma; Neurons; Oxygen; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Messenger; Time Factors; Transfection | 2013 |
The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast cancer cells and arrests breast tumor development.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Cell Proliferation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Female; Guanylate Cyclase; Hormone Antagonists; Humans; Immunoenzyme Techniques; Indazoles; Mammary Neoplasms, Animal; Mice; Mice, Nude; Mifepristone; Piperidines; Progestins; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2013 |
Antiangiogenic role of miR-361 in human umbilical vein endothelial cells: functional interaction with the peptide somatostatin.
Topics: Algorithms; Angiogenesis Inhibitors; Blotting, Western; Cell Hypoxia; Cell Proliferation; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Indazoles; MicroRNAs; Neovascularization, Pathologic; Polymerase Chain Reaction; Signal Transduction; Somatostatin; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2013 |
Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.
Topics: Animals; Cation Transport Proteins; Cell Line; Enzyme Activators; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Immunohistochemistry; Indazoles; Ischemia; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Rats; Retina; Retinal Diseases; Zinc Transporter 8 | 2012 |
The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activators; Gene Expression Regulation; Heart Rate; Heat Shock Transcription Factors; Heat Stroke; HSP70 Heat-Shock Proteins; Indazoles; Kidney; Liver; Male; Quercetin; Rats; Rats, Sprague-Dawley; Survival Rate; Transcription Factors | 2013 |
Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.
Topics: Animals; Blotting, Western; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Estrogen Antagonists; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Nude; Neoplastic Stem Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tamoxifen; Transplantation, Heterologous | 2013 |
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
Topics: Airway Resistance; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemotaxis; Eosinophils; Female; Gene Expression Regulation; Goblet Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Signal Transduction | 2013 |
Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.
Topics: Animals; Carbon Monoxide; Cross-Linking Reagents; Guanylate Cyclase; Indazoles; Manduca; Mass Spectrometry; Models, Molecular; Nitric Oxide; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Scattering, Small Angle; Soluble Guanylyl Cyclase; Structural Homology, Protein; Ultracentrifugation; X-Ray Diffraction | 2013 |
Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor κB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway.
Topics: Animals; Choroid; Chromones; Cinnamates; Cyclic S-Oxides; Imidazoles; Indazoles; Indoles; Maleimides; MAP Kinase Signaling System; Morpholines; NF-kappa B; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plicamycin; Pyridines; Retinal Pigment Epithelium; Signal Transduction; Sus scrofa; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
The nexus between VEGF and NFκB orchestrates a hypoxia-independent neovasculogenesis.
Topics: Blotting, Western; Cell Proliferation; Cells, Cultured; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Indazoles; Neovascularization, Physiologic; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Vascular Endothelial Growth Factor A | 2013 |
Protective effect of HIF-1α against hippocampal apoptosis and cognitive dysfunction in an experimental rat model of subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Blood Pressure; Caspase 3; Cognition Disorders; Disease Models, Animal; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Excitatory Amino Acid Transporter 2; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Maze Learning; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reaction Time; Subarachnoid Hemorrhage; Vascular Endothelial Growth Factor A | 2013 |
Adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Cell Culture Techniques; Cell Hypoxia; Cell Survival; Cells, Cultured; Dental Pulp; Genetic Vectors; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1; Indazoles; Membrane Proteins; Microtubule-Associated Proteins; Plasmids; Proto-Oncogene Proteins; Small Ubiquitin-Related Modifier Proteins; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2013 |
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Down-Regulation; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptor, PAR-2; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2013 |
CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Etoposide; Female; Furans; HSP90 Heat-Shock Proteins; Humans; Indazoles; Mice; Mice, SCID; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pyrazoles; Receptor, ErbB-2; Trastuzumab; Xenograft Model Antitumor Assays | 2013 |
The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.
Topics: Amyloid beta-Peptides; Animals; Calpain; Cell Differentiation; Guanylate Cyclase; HSP70 Heat-Shock Proteins; Indazoles; Neuroprotective Agents; Neurotoxins; PC12 Cells; Peptide Fragments; Phosphorylation; Rats; Signal Transduction; tau Proteins | 2013 |
Hypoxia-induced overexpression of DEC1 is regulated by HIF-1α in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cobalt; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Liver Neoplasms; RNA, Messenger; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2013 |
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Female; Fetal Growth Retardation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Proteinuria; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Suramin; Vasodilation; Vasodilator Agents | 2013 |
The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Survival; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; Cell Line; Enzyme Activation; Foam Cells; Guanylate Cyclase; Indazoles; Lipid Metabolism; Lipoproteins, LDL; Liver; Liver X Receptors; Macrophages; Mice; Mice, Knockout; Myocardium; Orphan Nuclear Receptors | 2014 |
YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.
Topics: Allosteric Regulation; Animals; Carbon Monoxide; Cattle; Guanylate Cyclase; Heme; Indazoles; Manduca; Models, Molecular; Nitric Oxide; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Surface Plasmon Resonance | 2014 |
YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Immunohistochemistry; Indazoles; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Sorafenib; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2014 |
Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression.
Topics: Angiogenesis Inhibitors; Animals; Cell Movement; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Inhibitor of Apoptosis Proteins; Interleukin-8; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Metabotropic Glutamate; Riluzole; Signal Transduction; Sirolimus; Skin Neoplasms; Survivin; Tumor Burden; Vascular Endothelial Growth Factor A | 2014 |
Inactivation of von Hippel-Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR-210/VMP1 signaling pathway.
Topics: Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Ovarian Neoplasms; Von Hippel-Lindau Tumor Suppressor Protein | 2014 |
YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mammary Neoplasms, Experimental; Mice; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-cbl; Structure-Activity Relationship | 2014 |
s-Methyl cysteine enhanced survival of nerve growth factor differentiated PC12 cells under hypoxic conditions.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Cell Differentiation; Cell Survival; Cysteine; DNA Fragmentation; Dose-Response Relationship, Drug; Glutathione Peroxidase; Glutathione Reductase; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Indazoles; Membrane Potential, Mitochondrial; Nerve Growth Factor; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pyridines; Pyrrolidines; Rats; Reactive Oxygen Species; Thiocarbamates; Tyrosine; Up-Regulation | 2014 |
VAV3 mediates resistance to breast cancer endocrine therapy.
Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activators; ErbB Receptors; Erlotinib Hydrochloride; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Variation; Humans; Indazoles; Letrozole; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-vav; Quinazolines; RNA Interference; RNA, Small Interfering; Tamoxifen; Toremifene; Triazoles | 2014 |
Repeated administration of ketamine can induce hippocampal neurodegeneration and long-term cognitive impairment via the ROS/HIF-1α pathway in developing rats.
Topics: Analgesics; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium Channel Blockers; Carnitine; Cells, Cultured; Cognition Disorders; Female; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ketamine; Male; Maze Learning; Neurodegenerative Diseases; Neurons; Nimodipine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Vitamin B Complex | 2014 |
Effects of YC-1 on learning and memory functions of aged rats.
Topics: Aging; Animals; Avoidance Learning; Indazoles; Male; Memory; Motor Activity; Rats, Wistar; Reaction Time | 2014 |
HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.
Topics: Animals; B-Lymphocytes; Calcium; Calcium Signaling; Cell Hypoxia; Cell Line; Cell Membrane; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Membrane Potentials; Mice; Oxygen; Potassium Channels, Tandem Pore Domain; Primary Cell Culture; RNA, Small Interfering | 2014 |
Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Collagen Type I; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Indazoles; Matrix Metalloproteinase 14; Neoplasm Invasiveness; Neoplasm Metastasis; Ovarian Neoplasms; RNA, Small Interfering; Snail Family Transcription Factors; Transcription Factors; Up-Regulation | 2015 |
Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; GTP-Binding Proteins; H-1 parvovirus; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neoplasm Proteins; Oncolytic Virotherapy; Pancreatic Neoplasms; Parvoviridae Infections; Receptors for Activated C Kinase; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Von Hippel-Lindau Tumor Suppressor Protein | 2015 |
The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents.
Topics: Actins; Apoptosis; Caspase 3; Cell Line; Cell Survival; Chemistry Techniques, Synthetic; Drug Design; Gene Expression Regulation, Enzymologic; Humans; Indazoles; Liver Cirrhosis; Structure-Activity Relationship | 2015 |
YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia.
Topics: Adult; Antigens, CD; Endoglin; Female; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Receptors, Cell Surface; Vascular Endothelial Growth Factor Receptor-1 | 2015 |
YC-1 induces lipid droplet formation in RAW 264.7 macrophages.
Topics: Animals; Cell Line; Cyclic GMP; Indazoles; Lipid Droplets; Lipoproteins, LDL; Macrophages; Mice; Second Messenger Systems | 2016 |
HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice.
Topics: Animals; Antioxidants; Cell Line; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Glucose Transporter Type 1; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Kidney; Mesangial Cells; Mice, Transgenic; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Recombinant Proteins; Renal Insufficiency; RNA Interference | 2016 |
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2016 |
Light-Emitting Diode Irradiation (640 nm) Regulates Keratinocyte Migration and Cytoskeletal Reorganization Via Hypoxia-Inducible Factor-1α.
Topics: Adult; Blotting, Western; Cell Movement; Cell Proliferation; Child; Cobalt; Cytoskeleton; Foreskin; Glycine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Keratinocytes; Low-Level Light Therapy; Male; Up-Regulation | 2016 |
Potent ameliorating effect of Hypoxia-inducible factor 1α (HIF-1α) antagonist YC-1 on combined allergic rhinitis and asthma syndrome (CARAS) in Rats.
Topics: Animals; Anti-Allergic Agents; Asthma; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung; Male; Nasal Mucosa; Ovalbumin; PPAR alpha; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; RNA, Messenger; Transcription Factor RelA | 2016 |
Partial Enteral Nutrition Mitigated Ischemia/Reperfusion-Induced Damage of Rat Small Intestinal Barrier.
Topics: Animals; Antioxidants; Enteral Nutrition; Enzyme Activators; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Intestinal Mucosa; Male; NF-kappa B; Parenteral Nutrition, Total; Proline; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Thiocarbamates; Tight Junctions | 2016 |
Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung Neoplasms; Mice, Nude; Molecular Targeted Therapy; Oligopeptides; Receptors, Notch; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2017 |
Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.
Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Glucosides; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Indazoles; Ligustrum; Plant Extracts; Pyrans; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Pigment Epithelium; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; beta Catenin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; ErbB Receptors; Head and Neck Neoplasms; Humans; Indazoles; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyridines; Soluble Guanylyl Cyclase; Squamous Cell Carcinoma of Head and Neck | 2017 |
[Hypoxic condition promotes olfactory mucosa mesenchymal stem cells to differentiate into neurons and
underlying mechanisms].
Topics: Blotting, Western; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Flow Cytometry; Glial Fibrillary Acidic Protein; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mesenchymal Stem Cells; Neurogenesis; Neuroglia; Neurons; Olfactory Mucosa; Potassium Channels; Signal Transduction; Tubulin | 2016 |
Establishment and characterization of a squamous cell carcinoma cell line, designated hZK-1, derived from a metastatic lymph node tumor of the tongue.
Topics: Aged, 80 and over; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Keratin-13; Keratin-17; Ki-67 Antigen; Lymphatic Metastasis; Mice, SCID; Tongue Neoplasms; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2017 |
The pivotal role of HIF-1α in lung inflammatory injury induced by septic mesenteric lymph.
Topics: A549 Cells; Animals; Cell Survival; Cytokines; Endothelial Cells; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung; Lung Injury; Lymph; Male; Mesenteric Arteries; Peroxidase; Pneumonia; Rats, Sprague-Dawley; Sepsis | 2017 |
Nitric oxide in the nucleus of the tractus solitarius is involved in hypoglycemic conditioned response.
Topics: Animals; Conditioning, Classical; Enzyme Inhibitors; Glucose; Homeostasis; Hypoglycemia; Indazoles; Insulin; Male; Menthol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nootropic Agents; Olfactory Perception; Proto-Oncogene Proteins c-fos; Random Allocation; Rats, Wistar; Solitary Nucleus | 2017 |
A novel individual-cell-based mathematical model based on multicellular tumour spheroids for evaluating doxorubicin-related delivery in avascular regions.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dibenzocycloheptenes; Doxorubicin; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neoplasms; Quinolines; Spheroids, Cellular; Tumor Cells, Cultured | 2017 |
Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetyl Coenzyme A; Anaerobiosis; Animals; Apoptosis; Carcinoma; Cell Line, Tumor; Deoxyguanosine; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Insulin; Mice; Nitroimidazoles; Oxidative Phosphorylation; Stomach Neoplasms; Tumor Hypoxia; Xenograft Model Antitumor Assays | 2017 |
YC-1 alleviates bone loss in ovariectomized rats by inhibiting bone resorption and inducing extrinsic apoptosis in osteoclasts.
Topics: Actins; Animals; Apoptosis; Bone Density Conservation Agents; Bone Resorption; Calpain; Cell Survival; Female; Humans; Indazoles; Lumbar Vertebrae; Osteoblasts; Osteoclasts; Osteoporosis; Ovariectomy; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; X-Ray Microtomography | 2018 |
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
Topics: Animals; Cell Differentiation; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Female; Fibroblasts; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Macrophages; Mice; Reverse Transcriptase Polymerase Chain Reaction; Tissue Adhesions | 2017 |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mutation; Neoplasm Metastasis; Transfection; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.
Topics: Adrenomedullin; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Ischemic Preconditioning; Kidney; Male; Malondialdehyde; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Triazoles; Up-Regulation | 2018 |
YC-1 Inhibits VEGF and Inflammatory Mediators Expression on Experimental Central Retinal Vein Occlusion in Rhesus Monkey.
Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Guanylate Cyclase; Indazoles; Inflammation; Intravitreal Injections; Macaca mulatta; Platelet Aggregation Inhibitors; Retinal Vein Occlusion; Vascular Endothelial Growth Factor A; Vitreous Body | 2018 |
Combination therapy with local radiofrequency ablation and YC-1 inhibits the proliferation and metastasis of hepatocellular carcinoma through activating β-catenin signaling.
Topics: Animals; Apoptosis; beta Catenin; Catheter Ablation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Combined Modality Therapy; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Indazoles; Liver Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation | 2016 |
Therapeutic window for YC‑1 following glutamate‑induced neuronal damage and transient focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Signaling; Cytoprotection; Glutamic Acid; Indazoles; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2018 |
A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro.
Topics: A549 Cells; Enzyme Inhibitors; Epithelial Cells; Flavin-Adenine Dinucleotide; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Microscopy, Fluorescence; NAD; Oxidation-Reduction; Radiation-Sensitizing Agents | 2018 |
YC‑1 reduces inflammatory responses by inhibiting nuclear factor‑κB translocation in mice subjected to transient focal cerebral ischemia.
Topics: Animals; Brain Edema; Brain Ischemia; Indazoles; Interleukin-1beta; Interleukin-6; Matrix Metalloproteinase 9; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke | 2018 |
Hypoxia-Targeting Organometallic Ru(II)-Arene Complexes with Enhanced Anticancer Activity in Hypoxic Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Coordination Complexes; Humans; Hydrophobic and Hydrophilic Interactions; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ligands; Ruthenium | 2018 |
YC-1 Prevents Tumor-Associated Tissue Factor Expression and Procoagulant Activity in Hypoxic Conditions by Inhibiting p38/NF-κB Signaling Pathway.
Topics: Blood Coagulation; Blood Platelets; Cell Line, Tumor; Cyclic Nucleotide-Regulated Protein Kinases; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Thromboplastin | 2019 |
MicroRNA-126 regulates Hypoxia-Inducible Factor-1α which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence.
Topics: Aging; Antagomirs; Cardiovascular Diseases; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Cellular Senescence; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; MicroRNAs; Neovascularization, Physiologic; Primary Cell Culture; Wound Healing | 2019 |
Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates having a HIF-1α inhibitor.
Topics: A549 Cells; Animals; Antineoplastic Agents; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Receptors, Vascular Endothelial Growth Factor; Tumor Hypoxia | 2019 |
Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.
Topics: Allosteric Regulation; Animals; Cryoelectron Microscopy; Indazoles; Manduca; Nitric Oxide; Protein Conformation; Soluble Guanylyl Cyclase | 2019 |
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
Topics: Amino Acids, Dicarboxylic; Animals; Apoptosis; Autophagy; Beclin-1; Cell Hypoxia; Cell Line; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Membrane Proteins; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Models, Animal; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
YC-1 potentiates the antitumor activity of gefitinib by inhibiting HIF-1α and promoting the endocytic trafficking and degradation of EGFR in gefitinib-resistant non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Endocytosis; ErbB Receptors; Gefitinib; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung Neoplasms; Protein Transport; Proteolysis | 2020 |
Hypoxia Inducible Factor-1α Inhibition in Von Hippel Lindau-mutant Malignant Pleural Mesothelioma Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mutation; Pleural Neoplasms; RNA, Small Interfering; Signal Transduction; Von Hippel-Lindau Tumor Suppressor Protein | 2020 |
YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells.
Topics: Antineoplastic Agents; Boron Neutron Capture Therapy; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Deferoxamine; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Large Neutral Amino Acid-Transporter 1; MCF-7 Cells; Neoplasms; Neutrons; Oxygen; Phenylalanine; Radiation-Sensitizing Agents; RNA, Small Interfering | 2020 |
Cilastatin Preconditioning Attenuates Renal Ischemia-Reperfusion Injury via Hypoxia Inducible Factor-1α Activation.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cilastatin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ischemic Preconditioning; Kidney; Male; Mice; Mice, Inbred C57BL; Protective Agents; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitination; Up-Regulation | 2020 |
HIF-1α-Mediated Mitophagy Determines ZnO Nanoparticle-Induced Human Osteosarcoma Cell Death both In Vitro and In Vivo.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Death; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Nanoparticles; Osteosarcoma; Particle Size; RNA, Small Interfering; Surface Properties; Tumor Cells, Cultured; Tumor Microenvironment; Zinc Oxide | 2020 |
Role and Regulation of Mechanotransductive HIF-1α Stabilisation in Periodontal Ligament Fibroblasts.
Topics: Adolescent; Adult; Cells, Cultured; Female; Fibroblasts; Focal Adhesion Kinase 1; Genistein; Glycine; Glycosaminoglycans; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Integrins; Male; Mechanotransduction, Cellular; Periodontal Ligament; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Stability; Signal Transduction; Stress, Mechanical; Tooth Movement Techniques; Urea; Vascular Endothelial Growth Factor A | 2020 |
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Topics: Animals; Brain Ischemia; Cerebral Hemorrhage; Endothelial Cells; HMGB1 Protein; Hypoxia-Inducible Factor 1; Indazoles; Male; Neutrophil Infiltration; NF-kappa B; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Stroke; Thromboembolism; Tissue Plasminogen Activator; Toll-Like Receptor 4 | 2021 |
HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib.
Topics: Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Amplification; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mutation; Phosphorylation; Proto-Oncogene Proteins c-met; Tumor Stem Cell Assay; Wound Healing | 2021 |
Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1α Downregulation for Tumor Treatment.
Topics: Cell Line, Tumor; Down-Regulation; Doxorubicin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Prodrugs; Tumor Hypoxia | 2021 |
Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Topics: Animals; Benzoates; Binding Sites; Cell Line; Cryoelectron Microscopy; Enzyme Activation; Enzyme Activators; Humans; Indazoles; Models, Molecular; Nitric Oxide; Protein Multimerization; Pyrazoles; Pyrimidines; Soluble Guanylyl Cyclase | 2021 |