Page last updated: 2024-08-21

indazoles and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

indazoles has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Chou, AH; Hu, SH; Wang, HL; Wang, SS; Weng, YH; Yeh, TH1
Allain, AV; Kadowitz, PJ; Lasker, GF; Murthy, SN; Pankey, EA; Stasch, JP1
Chen, D; Chen, YC; Du, GH; Fang, LH; Jiao, XZ; Niu, ZR; Xie, P; Yuan, TY; Zhang, HF1
Chen, D; Chen, Y; Du, G; Fang, L; Niu, Z; Yuan, T; Zhang, H1

Other Studies

4 other study(ies) available for indazoles and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

ArticleYear
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
    Neuropharmacology, 2013, Volume: 70

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Ataxin-3; Ataxin-7; Brain; Dose-Response Relationship, Drug; Gene Expression; Humans; Indazoles; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Niacinamide; Nuclear Proteins; Peptides; Proteasome Endopeptidase Complex; Pyridines; rho-Associated Kinases; Transcription Factors

2013
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
    Urology, 2013, Volume: 81, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors

2013
A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Indazoles; Male; Nitriles; Norepinephrine; Protein Kinase Inhibitors; Rats; Rats, Wistar; rho-Associated Kinases

2019
DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension.
    European journal of pharmacology, 2022, Mar-15, Volume: 919

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bosentan; Disease Models, Animal; Hypertension, Pulmonary; Indazoles; Male; Monocrotaline; Nitriles; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents

2022