Page last updated: 2024-08-21

indazoles and 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide

indazoles has been researched along with 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	24 (35.82)	29.6817
2010's	37 (55.22)	24.3611
2020's	6 (8.96)	2.80

Authors

Authors	Studies
Cheng, CY; Grima, J; Silvestrini, B	1
Cheng, CY; Grima, J; Johansson, E; Leone, MG; Mo , MY; Mruk, D; Palmery, M; Saso, L; Silvestrini, B; Zhu , LJ	1
Cheng, CY; Grima, J; Mo, My; Mruk, D; Saso, L; Silvestrini, B; Tita, B	1
Cheng, CY; Lee, WM; Lui, WY	1
Lau, AS; Mruk, DD	2
Chen, YM; Cheng, CY; Lee, NP; Lee, WM; Mruk, DD	1
Cheng, CY; Lee, NP	1
Cheng, CY; Lee, NP; Mruk, DD; Wong, CH	1
Cheng, CY; Xia, W	1
Bonanomi, M; Cheng, CY; Lee, NP; Lui, WY; Mo, MY; Mruk, D; Silvestrini, B; Siu, MK; Wong, CH	1
Mruk, DD; Sarkar, O; Xia, W	1
Cheng, CY; Mruk, DD; Silvestrini, B; Wong, CH	1
Cheng, CY; Lee, WM; Lie, PP; Mruk, DD; Wang, CQ; Wong, CH; Xia, W; Yan, HH	1
Cheng, CY; Lee, NP; Mruk, DD; Xia, W	1
Cheng, CY; Lee, WM; Mruk, DD; Xia, W	1
Attardi, B; Chakrasali, R; Georg, GI; Hild, SA; Jakkaraj, SR; Tash, JS	1
Mruk, DD	1
Mathur, PP; Sarkar, O	1
Cheng, CY; Lee, WM; Mruk, DD; Wong, EW	1
Cheng, CY; Lee, WM; Lie, PP; Mruk, DD	1
Bilinska, B; Cheng, CY; Kopera, IA; Mruk, DD; Su, L	1
Cheng, CY; Lee, WM; Li, MW; Sun, S; Wong, EW	1
Cheng, CY; Mruk, DD; Su, L	2
Chen, XX; Mao, YD; Sha, JH; Wang, H; Wang, LR; Zhou, ZM	1
Cheng, CY; Lee, WM; Mruk, DD; Xiao, X	1
Cheng, CY; Lie, PP; Lui, WY; Mok, KW; Mruk, DD	1
Cheng, CY; Lee, WM; Mok, KW; Mruk, DD	2
Cheng, CY; Lee, WM; Lui, WY; Mruk, DD; Su, L	1
Cheng, CY; Mok, KW; Mruk, DD; Silvestrini, B	1
Amory, JK; Nya-Ngatchou, JJ	1
Cheng, CY; Liu, T; Mruk, DD; Shao, J; Silvestrini, B; Wang, B; Xia, W; Xie, QR; Ying, W; Yu, H; Zhang, T	1
Chen, WY; Cheng, CY; Ge, RS; He, Y; Li, K; Lu, JX; Ni, Y; Shi, QX	1
Cheng, CY; Liu, T; Liu, Y; Mruk, DD; Shao, J; Silvestrini, B; Wang, B; Xia, W; Xie, QR; Yang, J; Zhang, T	1
Bonanomi, M; Cheng, CY; Cheng, YH; Jenardhanan, P; Mathur, PP; Mok, KW; Mruk, DD; Silvestrini, B; Su, L	1
Cheng, CY; Lie, PPY; Mannu, J; Mathur, PP; Mok, KW; Mruk, DD; Silvestrini, B	1
Cheng, CY; Mruk, DD; Qian, X; Wong, EW	1
Cheng, CY; Lie, PP; Mruk, DD; Qian, X; Wong, EW	1
Cheng, CY; Mruk, DD; Qian, X	1
Liu, T; Shen, H; Xia, W; Yu, H; Zhang, T	1
Celik-Ozenci, C; Cheng, CY; Gungor-Ordueri, NE	1
Cheng, CY; Cheng, YH; Jenardhanan, P; Mathur, PP; Qian, X; Silvestrini, B; Xia, W	1
Cheng, CY; Gao, WQ; Quan, Y; Shao, J; Xia, L; Xia, W; Yin, S	1
Cheng, CY; Cheng, YH; Geng, K; Liu, T; Quan, Y; Shao, J; Silvestrini, B; Wong, EW; Xia, W; Xie, QR; Yang, X; Zhang, T	1
Cheng, CY; Han, D; Lee, WM; Li, MW; Li, N; Mok, KW; Mruk, DD; Silvestrini, B; Wong, CK	1
Bonanomi, M; Chen, H; Cheng, CY; Mruk, DD; Silvestrini, B; Xia, W	1
Cheng, CY; Lee, WM; Tang, EI	1
Geng, K; Xia, W	1
Chen, H; Cheng, CY; Ge, R; Li, L; Lian, Q; Silvestrini, B; Tang, EI	1
Fu, N; Geng, K; Liu, T; Shao, J; Xia, W; Yan, A; Yang, X; Zhang, T	1
Qi, Y; Qiao, Q; Qin, X; Song, Q; Wu, T; Yang, C; Zhang, Z	1
Geng, Z; Jing, Y; Liu, YL; Tian, HL; Xia, WL; Xu, ZM; Yang, DX; Yang, GY; Yuan, F	1
Fu, N; Geng, K; Xia, W; Yang, X	1
Chen, H; Cheng, CY; Mruk, D; Silvestrini, B; Wong, CKC	1
Chen, Z; Li, Z; Wang, X; Xia, W; Yang, X; Zeng, Q	1
Cheng, CY; Ge, R; Li, H; Li, L; Li, SYT; Lian, Q; Mao, B; Mruk, D; Silvestrini, B; Yan, M	1
Gao, X; Tan, S; Wang, L; Wang, Q; Wu, G; Wu, J; Zou, C	1
Cheng, CY; Ge, R; Li, C; Li, L; Lian, Q; Mao, B; Silvestrini, B; Wong, CKC; Yan, M	1
Cheng, CY; Ge, R; Li, L; Lian, Q; Mao, B; Wong, CKC; Wu, S; Yan, M	1
Cheng, CY; Ge, R; Li, H; Silvestrini, B; Sun, F; Wang, L; Wong, CKC; Wu, S; Yan, M	1
Buabeid, M; Dhanasekaran, M; Dwyer, D; Fabbrini, M; Fujihashi, A; Govindarajulu, M; Lynd, T; Mohanakumar, KP; Moore, T; Neel, L; Ramesh, S; Shah, K; Smith, F	1
Cheng, CY; Li, L; Perrotta, A; Silvestrini, B; Sun, F; Wang, L; Wong, CKC; Wu, X	1
Chen, H; Cheng, CY; Jiang, Y; Mruk, DD	1
Cheng, CY; Li, L; Sun, F; Wong, CKC; Wu, S; Wu, X	1
Jeong, KH; Kim, WJ; Park, S; Zhu, J	1

Reviews

12 review(s) available for indazoles and 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide

Article	Year
Indazole carboxylic acids in male contraception. Contraception, 2002, Volume: 65, Issue:4 Topics: Animals; Antispermatogenic Agents; Benzyl Compounds; Contraceptive Agents, Male; Humans; Hydrazines; Indazoles; Intercellular Junctions; Male; Sertoli Cells; Spermatogenesis; Spermatozoa	2002
AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data. Contraception, 2005, Volume: 72, Issue:4 Topics: Animals; Biological Availability; Cell Adhesion; Contraceptive Agents, Male; Fertility; Hydrazines; Indazoles; Male; Rats; Rats, Sprague-Dawley; Sertoli Cells; Spermatozoa; Tissue Distribution	2005
New perspectives in non-hormonal male contraception. Trends in endocrinology and metabolism: TEM, 2008, Volume: 19, Issue:2 Topics: 1-Deoxynojirimycin; Animals; Calcium Channel Blockers; Contraception; Contraception, Immunologic; Contraceptive Agents, Male; Dimethyl Sulfoxide; Drug Design; Humans; Hydrazines; Indazoles; Indenes; Male; Maleates; Models, Biological; Nifedipine; Polyesters; Polystyrenes; Pyridines; Styrenes	2008
Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes. Reproduction (Cambridge, England), 2011, Volume: 141, Issue:5 Topics: Animals; Cell Adhesion; Contraceptive Agents, Male; Humans; Hydrazines; Indazoles; Indenes; Male; Piperidines; Seminiferous Epithelium; Sertoli Cells; Spermatogenesis; Spermatozoa	2011
New approaches to male non-hormonal contraception. Contraception, 2013, Volume: 87, Issue:3 Topics: Animals; Contraception; Contraceptive Agents, Male; Diamines; Humans; Hydrazines; Indazoles; Male; Retinoids; Tretinoin	2013
Interaction of oligomeric breast cancer resistant protein (BCRP) with adjudin: a male contraceptive with anti-cancer activity. Current molecular pharmacology, 2014, Volume: 7, Issue:2 Topics: Animals; Antineoplastic Agents; Antispermatogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Binding Sites; Biological Availability; Humans; Hydrazines; Indazoles; Ligands; Male; Models, Molecular; Neoplasm Proteins; Protein Binding; Protein Conformation; Spermatogenesis; Testis	2014
Adjudin--A Male Contraceptive with Other Biological Activities. Recent patents on endocrine, metabolic & immune drug discovery, 2015, Volume: 9, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Contraceptive Agents, Male; Hair Cells, Auditory; Humans; Hydrazines; Indazoles; Male	2015
Effective Delivery of Male Contraceptives Behind the Blood-Testis Barrier (BTB) - Lesson from Adjudin. Current medicinal chemistry, 2016, Volume: 23, Issue:7 Topics: Animals; Blood-Testis Barrier; Contraceptive Agents, Male; Drug Delivery Systems; Humans; Hydrazines; Indazoles; Male; Nanotechnology	2016
A sirtuin activator and an anti-inflammatory molecule-multifaceted roles of adjudin and its potential applications for aging-related diseases. Seminars in cell & developmental biology, 2016, Volume: 59 Topics: Aging; Animals; Anti-Inflammatory Agents; Disease; Humans; Hydrazines; Indazoles; Sirtuins; Spermatogenesis	2016
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease. Neurochemistry international, 2021, Volume: 144 Topics: Aging; Alzheimer Disease; Animals; Biphenyl Compounds; Dietary Supplements; Drug Delivery Systems; Enzyme Inhibitors; Glucosides; Humans; Hydrazines; Indazoles; Lignans; Neuroprotection; Phenols; Sirtuin 3	2021
mTORC1/rpS6 and p-FAK-Y407 signaling regulate spermatogenesis: Insights from studies of the adjudin pharmaceutical/toxicant model. Seminars in cell & developmental biology, 2022, Volume: 121 Topics: Animals; Humans; Hydrazines; Indazoles; Male; Mechanistic Target of Rapamycin Complex 1; Signal Transduction; Spermatogenesis	2022
Spermiation: Insights from Studies on the Adjudin Model. Advances in experimental medicine and biology, 2021, Volume: 1288 Topics: Animals; Hydrazines; Indazoles; Male; Rats; Seminiferous Epithelium; Spermatids; Spermatogenesis; Spermatogonia	2021

Other Studies

55 other study(ies) available for indazoles and 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide

Article	Year
Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide. Biology of reproduction, 2001, Volume: 64, Issue:5 Topics: Animals; Antispermatogenic Agents; Body Weight; Brain; Contraceptive Agents, Male; Epididymis; Female; Fertility; Follicle Stimulating Hormone; Hydrazines; Indazoles; Kidney; Litter Size; Liver; Luteinizing Hormone; Male; Organ Size; Prostate; Rats; Rats, Sprague-Dawley; Spermatogenesis; Testis; Testosterone	2001
Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biology of reproduction, 2001, Volume: 65, Issue:2 Topics: Animals; Benzyl Compounds; Cell Adhesion; Cell Count; Contraceptive Agents, Male; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Gene Expression; Hydrazines; Immunohistochemistry; Indazoles; Kidney; Liver; Luteinizing Hormone; Male; Organ Size; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seminiferous Epithelium; Spermatids; Spermatozoa; Testis; Testosterone	2001
Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway. Biology of reproduction, 2003, Volume: 68, Issue:6 Topics: Adherens Junctions; Algorithms; Amides; Animals; Brain; Cells, Cultured; Coculture Techniques; Germ Cells; GTP Phosphohydrolases; Hydrazines; Immunoblotting; Immunohistochemistry; Indazoles; Intracellular Signaling Peptides and Proteins; Kidney; Male; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoB GTP-Binding Protein; RNA, Messenger; Seminiferous Epithelium; Sertoli Cells; Signal Transduction; Testis	2003
Rab8B GTPase and junction dynamics in the testis. Endocrinology, 2003, Volume: 144, Issue:4 Topics: Adherens Junctions; Age Factors; Animals; Astrocytes; Cells, Cultured; Culture Media, Conditioned; Gene Expression; Gonadal Steroid Hormones; Hydrazines; In Vitro Techniques; Indazoles; Male; rab GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Spermatozoa; Testis; Testosterone	2003
Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biology of reproduction, 2003, Volume: 69, Issue:2 Topics: Adherens Junctions; Amino Acid Sequence; Animals; beta Catenin; Cadherins; Cells, Cultured; Coculture Techniques; Cytoskeletal Proteins; DNA Primers; Germ Cells; Hydrazines; Indazoles; Male; Molecular Sequence Data; Peptides; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seminiferous Tubules; Sertoli Cells; Spermatogenesis; Testis; Trans-Activators	2003
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. Journal of cellular physiology, 2005, Volume: 202, Issue:2 Topics: Adherens Junctions; Animals; beta Catenin; Cadherins; Casein Kinase II; Cell Adhesion; Cell Cycle; Cells, Cultured; Coculture Techniques; CSK Tyrosine-Protein Kinase; Cytoskeletal Proteins; Hydrazines; Indazoles; Male; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Spermatozoa; src-Family Kinases; Testis; Tissue Distribution; Trans-Activators	2005
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Biology of reproduction, 2005, Volume: 73, Issue:3 Topics: Adherens Junctions; Animals; beta Catenin; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeletal Proteins; Gene Expression Regulation; Hydrazines; Indazoles; Indoles; Male; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Signal Transduction; Spermatozoa; Trans-Activators	2005
TGF-beta3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras/ERK signaling pathway: An in vivo study. Developmental biology, 2005, Apr-15, Volume: 280, Issue:2 Topics: Animals; beta Catenin; Butadienes; Cadherins; Cytoskeletal Proteins; DNA-Binding Proteins; ets-Domain Protein Elk-1; Extracellular Matrix; Gene Expression Regulation, Developmental; Hydrazines; Image Processing, Computer-Assisted; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Indazoles; Kinetics; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; Occludin; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; ras Proteins; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Signal Transduction; Testis; Tight Junctions; Time Factors; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta3; Up-Regulation	2005
Adjudin-mediated junction restructuring in the seminiferous epithelium leads to displacement of soluble guanylate cyclase from adherens junctions. Journal of cellular physiology, 2006, Volume: 208, Issue:1 Topics: Adherens Junctions; Animals; Cadherins; Cell Adhesion; Cells, Cultured; Fluorescent Antibody Technique; Guanylate Cyclase; Hydrazines; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Indazoles; Intercellular Junctions; Male; Membrane Proteins; Microscopy, Immunoelectron; Occludin; Phosphoproteins; Protein Interaction Mapping; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Spermatogenesis; Spermatozoa; Testis; Zonula Occludens-1 Protein	2006
A male contraceptive targeting germ cell adhesion. Nature medicine, 2006, Volume: 12, Issue:11 Topics: Animals; Cell Adhesion; Contraceptive Agents, Male; Follicle Stimulating Hormone; Germ Cells; Hydrazines; Indazoles; Male; Rats; Rats, Sprague-Dawley; Testis	2006
Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes. The Journal of endocrinology, 2006, Volume: 191, Issue:3 Topics: Adherens Junctions; Animals; beta Catenin; Blood-Testis Barrier; Cadherins; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Dynamin II; Hydrazines; Immunohistochemistry; Indazoles; Male; Membrane Proteins; Microscopy, Fluorescence; Nectins; Occludin; Phosphoproteins; Rats; Rats, Sprague-Dawley; Spermatozoa; Testis; Zonula Occludens-1 Protein	2006
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes. The Journal of endocrinology, 2007, Volume: 192, Issue:1 Topics: Acrosome; Adherens Junctions; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Base Sequence; Cell Membrane; Cells, Cultured; DNA, Complementary; Hydrazines; In Situ Hybridization; Indazoles; Male; Microscopy, Fluorescence; Microscopy, Immunoelectron; Molecular Sequence Data; Open Reading Frames; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seminiferous Epithelium; Sequence Homology, Amino Acid; Sertoli Cells; Spermatids; Spermatogenesis; Transferases (Other Substituted Phosphate Groups)	2007
Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model. The Journal of endocrinology, 2007, Volume: 192, Issue:3 Topics: Animals; Base Sequence; Contraceptive Agents, Male; Cytokines; Gene Expression; Gene Expression Profiling; Germ Cells; Hydrazines; Indazoles; Intercellular Junctions; Male; Models, Animal; Models, Genetic; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, Cytokine; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Spermatogenesis; Testis	2007
A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose. Biology of reproduction, 2008, Volume: 78, Issue:6 Topics: Administration, Oral; Animals; Body Weight; Female; Fertility; Follicle Stimulating Hormone; Genitalia, Male; Hydrazines; Indazoles; Inhibins; Male; Organ Size; Pregnancy; Rats; Rats, Long-Evans; Spermatogenesis; Spermatogenesis-Blocking Agents; Testis; Time Factors	2008
Adjudin-mediated germ cell depletion alters the anti-oxidant status of adult rat testis. Molecular reproduction and development, 2009, Volume: 76, Issue:1 Topics: Aging; Androgen-Binding Protein; Animals; Antioxidants; Cell Survival; Germ Cells; Hydrazines; Indazoles; Male; Organ Size; Rats; Rats, Wistar; Testis	2009
Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-15, Volume: 105, Issue:28 Topics: Adaptor Proteins, Signal Transducing; Animals; Blood-Testis Barrier; Carrier Proteins; Cell Movement; Cell Polarity; Hydrazines; Indazoles; Male; Nerve Tissue Proteins; Rats; Spermatids; Spermatogenesis; Testis	2008
RAB13 participates in ectoplasmic specialization dynamics in the rat testis. Biology of reproduction, 2009, Volume: 80, Issue:3 Topics: Animals; Cells, Cultured; Cytoskeleton; DNA, Complementary; GTP Phosphohydrolases; Hydrazines; Indazoles; Intercellular Junctions; Male; Microfilament Proteins; Molecular Sequence Data; rab GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Spermatocytes; Testis; Vinculin	2009
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:8 Topics: Actins; Adaptor Proteins, Signal Transducing; Adherens Junctions; Animals; Base Sequence; Blood-Testis Barrier; Cell Adhesion; Cells, Cultured; DNA Primers; Hydrazines; Indazoles; Male; Proteins; Rats; Rats, Sprague-Dawley; RNA Interference; Seminiferous Epithelium; Sertoli Cells; Spermatids; Spermatogenesis	2009
An in vivo study on adjudin and blood-testis barrier dynamics. Endocrinology, 2009, Volume: 150, Issue:10 Topics: Actins; Adaptor Proteins, Vesicular Transport; Animals; Blood-Testis Barrier; Hydrazines; Indazoles; Male; Organ Size; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Tight Junctions	2009
14-3-3 Protein regulates cell adhesion in the seminiferous epithelium of rat testes. Endocrinology, 2009, Volume: 150, Issue:10 Topics: 14-3-3 Proteins; Actins; Adaptor Proteins, Signal Transducing; Animals; Blood-Testis Barrier; Carrier Proteins; Cell Adhesion; Endocytosis; Gene Knockdown Techniques; Hydrazines; Indazoles; Male; Rats; Seminiferous Epithelium; Sertoli Cells; Spermatids; Tight Junctions	2009
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier. The international journal of biochemistry & cell biology, 2009, Volume: 41, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Testis Barrier; Cell Adhesion; Hydrazines; Indazoles; Male; Multidrug Resistance-Associated Proteins; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Sodium-Glucose Transporter 1; Spermatogenesis; Spermatogonia; Testis; Tight Junctions	2009
AF-2364 is a prospective spermicide candidate. Asian journal of andrology, 2010, Volume: 12, Issue:3 Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Survival; Cyclosporine; Drug Therapy, Combination; Humans; Hydrazines; Indazoles; Male; Mice; Mitochondria; Permeability; Seminal Plasma Proteins; Sperm Motility; Spermatocidal Agents; Spermatozoa; Tetrazolium Salts; Thiazoles	2010
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo. The international journal of biochemistry & cell biology, 2010, Volume: 42, Issue:11 Topics: Animals; Blood-Testis Barrier; Cell Proliferation; Cells, Cultured; Hydrazines; Indazoles; Male; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Tight Junctions	2010
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:4 Topics: Actin Cytoskeleton; Adherens Junctions; Animals; Blood-Testis Barrier; Cell Adhesion; Clathrin; Endocytosis; Gene Expression Regulation, Developmental; Hydrazines; Indazoles; Indoles; Male; Proto-Oncogene Proteins c-yes; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Spermatids; Spermatogenesis; Sulfonamides; Transforming Growth Factor beta3	2011
Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility. International journal of andrology, 2012, Volume: 35, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Hydrazines; Indazoles; Male; Rats; Spermatogenesis; Spermatogonia; Stem Cells	2012
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Blood-Testis Barrier; Endocytosis; Focal Adhesion Protein-Tyrosine Kinases; Hydrazines; Immunoblotting; Indazoles; Kinetics; Male; Membrane Proteins; Microscopy, Confocal; Occludin; Phosphoproteins; Primary Cell Culture; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; RNA Interference; Sertoli Cells; Zonula Occludens-1 Protein	2011
rpS6 Regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment. Endocrinology, 2012, Volume: 153, Issue:10 Topics: Actins; Animals; Blood-Testis Barrier; Hydrazines; Indazoles; Male; Permeability; Protein Transport; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Sertoli Cells; Signal Transduction; Spermatogenesis; Tight Junctions	2012
Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation. Journal of neuroimmunology, 2013, Jan-15, Volume: 254, Issue:1-2 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Brain Edema; Brain Infarction; CD11b Antigen; Cell Line, Transformed; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hydrazines; Indazoles; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Microglia; Nervous System Diseases; NF-kappa B; Psychomotor Performance; Signal Transduction; Time Factors	2013
Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans. Human reproduction (Oxford, England), 2013, Volume: 28, Issue:1 Topics: Acrosome Reaction; Adenylyl Cyclase Inhibitors; Adult; Animals; Chloride Channels; Chlorides; Contraceptive Agents, Male; Cricetinae; Cyclic AMP; Egg Proteins; Enzyme Inhibitors; Female; Fertilization; Humans; Hydrazines; Indazoles; Male; Membrane Glycoproteins; Membrane Transport Modulators; Phosphodiesterase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Receptors, Cell Surface; Recombinant Proteins; Sperm Capacitation; Spermatozoa; Zona Pellucida Glycoproteins	2013
Male contraceptive Adjudin is a potential anti-cancer drug. Biochemical pharmacology, 2013, Feb-01, Volume: 85, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Contraceptive Agents, Male; Humans; Hydrazines; Indazoles; Male; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental	2013
Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:3 Topics: Actins; Animals; Blood-Testis Barrier; Carrier Proteins; Cell Communication; Down-Regulation; Gap Junctions; Gene Knockdown Techniques; Hydrazines; Indazoles; Male; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Rapamycin-Insensitive Companion of mTOR Protein; Rats; Rats, Sprague-Dawley; Seminiferous Epithelium; Sertoli Cells; Stress Fibers; TOR Serine-Threonine Kinases; Zonula Occludens-1 Protein	2013
Role of P-glycoprotein at the blood-testis barrier on adjudin distribution in the testis: a revisit of recent data. Advances in experimental medicine and biology, 2012, Volume: 763 Topics: Adherens Junctions; Amino Acid Motifs; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Testis Barrier; Contraceptive Agents, Male; Humans; Hydrazines; Indazoles; Male; Metabolic Clearance Rate; Molecular Docking Simulation; Molecular Sequence Data; Multiprotein Complexes; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Spermatids; Testis	2012
The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception. Advances in experimental medicine and biology, 2012, Volume: 763 Topics: Adherens Junctions; Amino Acid Sequence; Animals; Blood-Testis Barrier; Catalytic Domain; Contraception; Contraceptive Agents, Male; Humans; Hydrazines; Hydrogen Bonding; Indazoles; Integrin alpha6beta1; Male; Molecular Docking Simulation; Molecular Sequence Data; Occludin; Seminiferous Epithelium; Sequence Alignment; Sertoli Cells; Spermatogenesis	2012
Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. American journal of physiology. Endocrinology and metabolism, 2013, Apr-01, Volume: 304, Issue:7 Topics: Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Testis Barrier; Contraceptive Agents, Male; Endothelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Hydrazines; Indazoles; Male; Microvessels; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seminiferous Epithelium; Sertoli Cells; Spermatids; Spermatogenesis; Spermatozoa	2013
Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes. Endocrinology, 2013, Volume: 154, Issue:5 Topics: Actin Cytoskeleton; Age Factors; Animals; Blood-Testis Barrier; Cell Differentiation; Cells, Cultured; Cytoskeletal Proteins; Hydrazines; Indazoles; Male; Phosphoproteins; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Sertoli Cells; Testis; Tight Junctions	2013
Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis. PloS one, 2013, Volume: 8, Issue:4* Topics: Actins; Animals; Cytoskeletal Proteins; Hydrazines; Immunoblotting; Immunoprecipitation; Indazoles; Male; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sertoli Cells; Spermatogenesis; Testis; Tight Junctions; Transcription Factors	2013
Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption. Journal of neuroinflammation, 2014, Jun-14, Volume: 11 Topics: Animals; Blood-Brain Barrier; Brain; Brain Infarction; CD11b Antigen; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hydrazines; Indazoles; Matrix Metalloproteinase 9; Mice; Microglia; Neurologic Examination; Neuroprotective Agents; Nitric Oxide Synthase Type II; Occludin; Reperfusion Injury; Zonula Occludens-1 Protein	2014
Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis. American journal of physiology. Endocrinology and metabolism, 2014, Nov-01, Volume: 307, Issue:9 Topics: Actin Cytoskeleton; Adaptor Proteins, Signal Transducing; Animals; Blood-Testis Barrier; Cell Polarity; Cells, Cultured; Contraceptive Agents, Male; Cytoplasm; Gene Expression Regulation, Developmental; Gene Silencing; Hydrazines; Indazoles; Male; Microfilament Proteins; Phosphoprotein Phosphatases; Protein Transport; Rats, Sprague-Dawley; RNA, Small Interfering; Sertoli Cells; Spermatids; Spermatogenesis; Testis; Tight Junctions	2014
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway. Scientific reports, 2015, Feb-02, Volume: 5 Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Cochlea; Disease Models, Animal; Epithelium; Gentamicins; Hair Cells, Auditory; Hearing Loss; Hydrazines; Immunohistochemistry; Indazoles; Mice; Mice, Inbred C57BL; Organ of Corti; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirtuin 3; Up-Regulation	2015
Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:4 Topics: Animals; Blood-Testis Barrier; Connexin 43; Gene Expression; Hydrazines; Immunoblotting; Indazoles; Male; Meiosis; Mice, Knockout; Microscopy, Fluorescence; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sertoli Cells; Spermatids; Spermatogenesis; Spermatogonia; Testis	2016
Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis. Endocrinology, 2016, Volume: 157, Issue:4 Topics: Actins; Animals; Cytoskeleton; Focal Adhesion Protein-Tyrosine Kinases; Hydrazines; Immunohistochemistry; Indazoles; Male; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; Phagosomes; Rats, Sprague-Dawley; Seminiferous Epithelium; Spermatids; Spermatogenesis; Testis; Tubulin	2016
Sperm Release at Spermiation Is Regulated by Changes in the Organization of Actin- and Microtubule-Based Cytoskeletons at the Apical Ectoplasmic Specialization-A Study Using the Adjudin Model. Endocrinology, 2017, 12-01, Volume: 158, Issue:12 Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Cytoskeleton; Fetal Proteins; Formins; Hydrazines; Indazoles; Male; Microfilament Proteins; Microscopy, Fluorescence; Microtubules; Nuclear Proteins; Rats, Sprague-Dawley; Seminiferous Epithelium; Spermatids; Spermatogenesis; Spermatozoa; Time Factors	2017
Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice. Stem cell research & therapy, 2017, Nov-07, Volume: 8, Issue:1 Topics: Animals; Brain Ischemia; Hydrazines; Indazoles; Mice; Neural Stem Cells; Neuroprotection; Reperfusion Injury; Survival Analysis	2017
Micelle System Based on Molecular Economy Principle for Overcoming Multidrug Resistance and Inhibiting Metastasis. Molecular pharmaceutics, 2018, 03-05, Volume: 15, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Delayed-Action Preparations; Doxorubicin; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Hydrazines; Indazoles; Lung; Lung Neoplasms; MCF-7 Cells; Mice; Mice, Inbred BALB C; Micelles; Nanomedicine; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tissue Distribution; Treatment Outcome; Vitamin E; Xenograft Model Antitumor Assays	2018
Adjudin Attenuates Cerebral Edema and Improves Neurological Function in Mice with Experimental Traumatic Brain Injury. Journal of neurotrauma, 2018, 12-01, Volume: 35, Issue:23 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Hydrazines; Indazoles; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function	2018
Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production. International journal of molecular medicine, 2018, Volume: 42, Issue:6 Topics: Animals; Cellular Senescence; Embryo, Mammalian; Fibroblasts; Hydrazines; Hydroxyurea; Indazoles; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Sirtuin 3; Up-Regulation	2018
F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin. Contraception, 2019, Volume: 99, Issue:6 Topics: Animals; Blood-Testis Barrier; Female; Hydrazines; Indazoles; Laminin; Male; Microtubules; Peptide Fragments; Proof of Concept Study; Rats; Rats, Sprague-Dawley; Sertoli Cells; Spermatogenesis; Transfection	2019
Adjudin synergizes with paclitaxel and inhibits cell growth and metastasis by regulating the sirtuin 3-Forkhead box O3a axis in human small-cell lung cancer. Thoracic cancer, 2019, Volume: 10, Issue:4 Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Synergism; Female; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Humans; Hydrazines; Indazoles; Lung Neoplasms; Male; Mice; Paclitaxel; Sirtuin 3; Small Cell Lung Carcinoma; Xenograft Model Antitumor Assays	2019
mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model. American journal of physiology. Endocrinology and metabolism, 2019, 07-01, Volume: 317, Issue:1 Topics: Animals; Blood-Testis Barrier; Contraceptive Agents, Male; Hydrazines; Indazoles; Male; Mechanistic Target of Rapamycin Complex 1; Mutagenesis, Site-Directed; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Seminiferous Epithelium; Sertoli Cells; Signal Transduction; Spermatocytes; Spermatogenesis	2019
Doxorubicin and adjudin co-loaded pH-sensitive nanoparticles for the treatment of drug-resistant cancer. Acta biomaterialia, 2019, Volume: 94 Topics: Animals; Delayed-Action Preparations; Doxorubicin; Drug Resistance, Neoplasm; Humans; Hydrazines; Hydrogen-Ion Concentration; Indazoles; MCF-7 Cells; Mice; Nanoparticles; Neoplasms, Experimental; Xenograft Model Antitumor Assays	2019
F5-Peptide and mTORC1/rpS6 Effectively Enhance BTB Transport Function in the Testis-Lesson From the Adjudin Model. Endocrinology, 2019, 08-01, Volume: 160, Issue:8 Topics: Actins; Animals; Biological Transport; Blood-Testis Barrier; Cytoskeleton; Hydrazines; Indazoles; Laminin; Male; Mechanistic Target of Rapamycin Complex 1; Peptide Fragments; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Signal Transduction; Spermatogenesis; Testis; Tight Junction Proteins	2019
mTORC1/rpS6 and spermatogenic function in the testis-insights from the adjudin model. Reproductive toxicology (Elmsford, N.Y.), 2019, Volume: 89 Topics: Animals; Blood-Testis Barrier; Contraceptive Agents, Male; Dose-Response Relationship, Drug; Hydrazines; Indazoles; Male; Mechanistic Target of Rapamycin Complex 1; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Sertoli Cells; Spermatogenesis; Transfection	2019
The Non-hormonal Male Contraceptive Adjudin Exerts its Effects via MAPs and Signaling Proteins mTORC1/rpS6 and FAK-Y407. Endocrinology, 2021, 01-01, Volume: 162, Issue:1 Topics: Animals; Cadmium Chloride; Focal Adhesion Kinase 1; Gene Expression Regulation; Hydrazines; Indazoles; Male; Mechanistic Target of Rapamycin Complex 1; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6; Signal Transduction	2021
AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10 Topics: A Kinase Anchor Proteins; Actin Cytoskeleton; Animals; Cell Nucleus; Cytoskeletal Proteins; Hydrazines; Indazoles; Male; Microtubules; Models, Animal; Rats; Sertoli Cells; Spermatogenesis; Testis	2021
Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus. Brain research bulletin, 2022, Volume: 182 Topics: Animals; Hydrazines; Indazoles; Male; Mammals; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Pilocarpine; Status Epilepticus; TOR Serine-Threonine Kinases	2022