incednine has been researched along with 3-aminobutyric-acid* in 1 studies
1 other study(ies) available for incednine and 3-aminobutyric-acid
| Article | Year |
|---|---|
A unique pathway for the 3-aminobutyrate starter unit from L-glutamate through β-glutamate during biosynthesis of the 24-membered macrolactam antibiotic, incednine.
Incednine is a 24-membered macrolactam antibiotic produced by Streptomyces sp. ML694-90F3. A previous study demonstrated that its unique nitrogen-containing starter unit was derived from L-glutamate. To elucidate the missing link between L-glutamate and the starter unit, deuterium labeled amino acid feeding experiments were conducted. These experiments revealed that 3-[3-(2)H]aminobutyrate and β-[2,2,4,4-(2)H(4)]glutamate were incorporated into the starter moiety. The results indicate that a novel decarboxylation of β-glutamate to give 3-aminobutyrate is involved in incednine biosynthesis. Topics: Aminobutyrates; Disaccharides; Glutamic Acid; Lactams; Molecular Structure; Stereoisomerism; Streptomyces | 2012 |