Page last updated: 2024-08-24

imirestat and tolrestat

imirestat has been researched along with tolrestat in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's6 (50.00)18.2507
2000's3 (25.00)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DuPriest, MT; Griffin, BW; Kuzmich, D; McNatt, LG1
Carper, DA; Hohman, TC; Kitchen, D; Malamas, MS; Nilakantan, R; Singh, SB1
Matsuura, Y; Nishimura, C; Tanimoto, T; Yamaoka, T; Yamashita, K1
Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR1
Bannai, C; Itakura, M; Oda, A; Yamaoka, T; Yamashita, K1
Lou, MF; Xu, GT; York, B; Zigler, S1
Carper, D; Sato, S; Sugiyama, K1
Kador, PF; Lee, YS; Sato, S; Sugiyama, K1
Chen, Z; Kador, PF; Lee, YS; Sugiyama, K1
Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF1
Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA1
Kador, PF; Zhang, P; Zhang, Z1

Other Studies

12 other study(ies) available for imirestat and tolrestat

ArticleYear
Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:11

    Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Enzyme Inhibitors; Rats; Spiro Compounds; Structure-Activity Relationship; Thiazoles

1991
Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.
    Journal of medicinal chemistry, 2000, Mar-23, Volume: 43, Issue:6

    Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phthalazines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles

2000
Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase.
    Biochemical and biophysical research communications, 1992, Feb-28, Volume: 183, Issue:1

    Topics: Aldehyde Reductase; Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Fluorenes; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Naphthalenes; Structure-Activity Relationship

1992
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
    Diabetes, 1989, Volume: 38, Issue:10

    Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance

1989
The effect of non-enzymatic glycation on recombinant human aldose reductase.
    Diabetes research and clinical practice, 1995, Volume: 27, Issue:3

    Topics: Aldehyde Reductase; Enzyme Inhibitors; Fluorenes; Glucose; Glycosylation; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Naphthalenes; Phthalazines; Recombinant Proteins; Substrate Specificity; Transfection

1995
Inhibition of naphthalene cataract in rats by aldose reductase inhibitors.
    Current eye research, 1996, Volume: 15, Issue:4

    Topics: Aldehyde Reductase; Animals; Cataract; Culture Techniques; Disease Models, Animal; Enzyme Inhibitors; Fluorenes; Galactose; Hydantoins; Imidazoles; Imidazolidines; Male; Naphthalenes; Rats; Spiro Compounds

1996
Aldose reductase as dihydrodiol dehydrogenase. Naphthoquinone formation by rat lens aldose reductase.
    Advances in experimental medicine and biology, 1997, Volume: 414

    Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Eye Proteins; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthoquinones; Oxidoreductases; Phthalazines; Rats

1997
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
    Experimental eye research, 1999, Volume: 68, Issue:5

    Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inhibitors; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthols; Naphthoquinones; Phthalazines; Rats; Spectrophotometry

1999
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex.
    Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4

    Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Fluorenes; Humans; Hydantoins; Lens, Crystalline; Models, Molecular; Muscles; NADP; Naphthalenes; Phthalazines; Rats

2000
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:2

    Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence

2000
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
    Journal of periodontology, 2011, Volume: 82, Issue:6

    Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Glycolysis; Hydantoins; Lipopolysaccharides; Male; Naphthalenes; Periodontitis; Quercetin; Rats; Rats, Sprague-Dawley; Sorbitol

2011
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2014, Volume: 30, Issue:1

    Topics: Aldehyde Reductase; Animals; Capillaries; Cell Line; Endothelial Cells; Fluorenes; Galactitol; Galactose; Glucose; Hydantoins; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Naphthalenes; Pericytes; Rats; Rats, Transgenic; Retinal Vessels; Sorbitol

2014