imirestat has been researched along with sorbitol in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diemel, LT; Stevens, EJ; Tomlinson, DR; Willars, GB | 1 |
| Sato, S | 1 |
| Calcutt, NA; Carrington, AL; Ettlinger, CB; Tomlinson, DR | 1 |
| Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
| Hu, TS; Li, WY; Qin, M; Tang, L; Zhou, Q | 1 |
| Chandler, ML; Griffin, BW; McNatt, LG; York, BM | 1 |
| Dickerson, JE; Garadi, R; Lou, MF; York, BM | 1 |
| Broderick, CL; Fuller, RW; Hemrick-Luecke, SK; Perry, KW; Yen, TT | 1 |
| Averbuch, M; Brazzell, RK; Dobbs, RE; Liao, JC; Weintraub, M | 1 |
| Dunlop, ME; Keogh, RJ; Larkins, RG | 1 |
| Akagi, Y; Kador, PF; Kubo, E; Lee, JW; Lizak, MJ; Sato, S; Secchi, EF | 1 |
| Eisenhofer, G; Fujisawa, S; Kador, PF; Kawamura, M; Kopin, IJ; Lee, YS; Lizak, MJ; Sato, S; Sinz, A; Tsai, JY | 1 |
| Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF | 1 |
| Kador, PF; Lizak, MJ; Mori, K | 1 |
| Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA | 1 |
| Kador, PF; Zhang, P; Zhang, Z | 1 |
1 trial(s) available for imirestat and sorbitol
| Article | Year |
|---|---|
Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients.
Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Double-Blind Method; Erythrocytes; Female; Fluorenes; Humans; Hydantoins; Hypoglycemic Agents; Male; Middle Aged; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
15 other study(ies) available for imirestat and sorbitol
| Article | Year |
|---|---|
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Fluorenes; Fructose; Glucose; Hydantoins; Inositol; Insulin; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Substance P | 1992 |
Rat kidney aldose reductase and aldehyde reductase and polyol production in rat kidney.
Topics: Aldehyde Reductase; Animals; Chromatography, Gas; Diet; Female; Fluorenes; Galactitol; Galactose; Hydantoins; Kidney; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol | 1992 |
Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats.
Topics: Action Potentials; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electric Conductivity; Electrophysiology; Fluorenes; Fructose; Glucose; Hydantoins; Hypoxia; Insulin; Male; Neural Conduction; Ouabain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin | 1991 |
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.
Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance | 1989 |
Attenuation of phosphoinositidase activity and phosphatidylinositol bisphosphate level of bovine retinal capillary pericytes in high glucose.
Topics: 1-Phosphatidylinositol 4-Kinase; Aldehyde Reductase; Animals; Capillaries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Fluorenes; Glucose; Hydantoins; Inositol; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Retinal Vessels; Sorbitol | 1989 |
Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Humans; Hydantoins; In Vitro Techniques; Kinetics; Lens, Crystalline; Male; Placenta; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Glutathione depletion in the lens of galactosemic and diabetic rats.
Topics: Aldehyde Reductase; Aminoisobutyric Acids; Animals; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Fluorenes; Galactitol; Galactosemias; Glutathione; Glutathione Reductase; Hydantoins; Lens, Crystalline; Male; NAD; NADP; Rats; Rats, Inbred Strains; Sorbitol | 1988 |
AL-1576, an aldose reductase inhibitor (ARI), did not prevent the decrease of norepinephrine turnover in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Hydantoins; Lens, Crystalline; Norepinephrine; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation.
Topics: Aldehyde Reductase; Animals; Arachidonic Acids; Cell Membrane; Diabetes Mellitus, Experimental; Diglycerides; Enzyme Activation; Fluorenes; Glucose; Hydantoins; Hyperglycemia; In Vitro Techniques; Kidney Glomerulus; Male; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sorbitol; Streptozocin; Time Factors | 1997 |
3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy.
Topics: Aldehyde Reductase; Animals; Deoxyglucose; Dogs; Enzyme Inhibitors; Epithelial Cells; Fluorenes; Fluorine; Fructose; Gluconates; Hydantoins; Immunoenzyme Techniques; Lens, Crystalline; Magnetic Resonance Spectroscopy; Polymers; Sorbitol | 1998 |
Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats.
Topics: Aldehyde Reductase; Animals; Deamination; Enzyme Inhibitors; Fluorenes; Hydantoins; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Sprague-Dawley; Sorbitol; Superior Cervical Ganglion | 1999 |
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence | 2000 |
Determination of aldose reductase activity in the eye by localized magnetic resonance spectroscopy.
Topics: Aldehyde Reductase; Animals; Deoxyglucose; Enzyme Inhibitors; Fluorenes; Hydantoins; Lens, Crystalline; Magnetic Resonance Spectroscopy; Rabbits; Sorbitol | 2001 |
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats.
Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Glycolysis; Hydantoins; Lipopolysaccharides; Male; Naphthalenes; Periodontitis; Quercetin; Rats; Rats, Sprague-Dawley; Sorbitol | 2011 |
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells.
Topics: Aldehyde Reductase; Animals; Capillaries; Cell Line; Endothelial Cells; Fluorenes; Galactitol; Galactose; Glucose; Hydantoins; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Naphthalenes; Pericytes; Rats; Rats, Transgenic; Retinal Vessels; Sorbitol | 2014 |