Page last updated: 2024-08-24

imirestat and hydantoins

imirestat has been researched along with hydantoins in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (23.81)	18.7374
1990's	36 (57.14)	18.2507
2000's	8 (12.70)	29.6817
2010's	4 (6.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Diemel, LT; Stevens, EJ; Tomlinson, DR; Willars, GB	1
Barker, R; Barratt, D; Brazzell, K; DuPriest, M; Griffin, B; Mayer, P; Park, YH; York, B	1
Sato, S	1
Gilbert, PJ; Hartley, TE; Troke, JA; Turcan, RG; Vose, CW; Watson, KV	1
Banfield, CR; Brazzell, RK; Chien, JY; Mayer, PR; Slattery, JT	1
Lou, MF; Xu, GT; Zigler, JS	2
Matsuura, Y; Nishimura, C; Tanimoto, T; Yamaoka, T; Yamashita, K	1
Desouky, MA; Geller, AM; Jernigan, HM	1
Gilbert, PJ; Hoyle, VR; Nicholson, JK; Troke, JA; Vose, CW	1
Calcutt, NA; Carrington, AL; Ettlinger, CB; Tomlinson, DR	1
Holleschau, AM; Rathbun, WB; Tao, RV	1
Brazzell, RK; Dobbs, R; Mayer, PR; McNamara, PJ; Slattery, JT; Teng, RL	1
Giblin, FJ; Kador, PF; Kinoshita, JH; Lin, LR; Reddy, VN	1
Boltralik, JJ; Brazzell, RK; McCue, BA; Park, YH	1
Eaton, JW; Hunt, JV; Jiang, ZY; Koppenol, WH; Wolff, SP; Zhou, QL	1
Barker, RC; Brazzell, RK; Hudson, JE; Park, YH; York, BM	1
Brazzell, RK; Hackett, RB; McCue, BA; Wooldridge, CB	1
Kador, PF; Sato, S	1
Bera, RK; Brazzell, RK; Jay, M; Mayer, PR; Vaidyanathan, G	1
Chang, K; Eades, DM; Kilo, C; Province, MA; Pugliese, G; Sherman, WR; Tilton, RG; Williamson, JR	1
Hockwin, O; Krolczyk, J; Mayer, PR; McCue, BA; Müller, P	1
Brazzell, RK; Chandler, ML; Dickerson, JE; Lou, MF; York, BM	1
Hu, TS; Li, WY; Qin, M; Tang, L; Zhou, Q	1
Janis, LJ; Miller, TD; Pinkerton, TC	1
Garner, MH; Spector, A; Wang, GM	1
Garner, MH; Spector, A	1
Chandler, ML; Griffin, BW; McNatt, LG; York, BM	1
Brazzell, RK; Mattern, J; Park, YH; Stoltz, ML; Wooldridge, CB	1
Dickerson, JE; Garadi, R; Lou, MF; York, BM	1
Broderick, CL; Fuller, RW; Hemrick-Luecke, SK; Perry, KW; Yen, TT	1
Hockwin, O; Schmidt, J; Schmitt, C; Wegener, A	1
Averbuch, M; Brazzell, RK; Dobbs, RE; Liao, JC; Weintraub, M	1
Blouin, RA; Brazzell, RK; McNamara, PJ	2
Bannai, C; Itakura, M; Oda, A; Yamaoka, T; Yamashita, K	1
Caspers-Velu, LE; Kador, PF; Rapoport, SI; Wadhwani, KC	2
Sanders, RA; Sastry, SG; Veltman, JC; Watkins, JB	1
Lou, MF; Xu, GT; York, B; Zigler, S	1
Nourooz-Zadeh, J; Ou, P; Tritschler, HJ; Wolff, S	1
Dunlop, ME; Keogh, RJ; Larkins, RG	1
Carper, D; Sato, S; Sugiyama, K	1
Crider, JY; Griffin, BW; Sharif, NA; Yorio, T	1
Chung, SS; Lee, AY	1
Glover, JP; Hosotani, H; Jacot, JL; Lois, N; Robison, WG	1
Blessing, K; Greentree, W; Inoue, J; Kador, PF; Lackner, PA; Lizak, MJ; Mori, K; Rodriguez, L; Sato, S; Secchi, EF	1
Akagi, Y; Kador, PF; Kubo, E; Lee, JW; Lizak, MJ; Sato, S; Secchi, EF	1
Kador, PF; Lee, YS; Sato, S; Sugiyama, K	1
Eisenhofer, G; Fujisawa, S; Kador, PF; Kawamura, M; Kopin, IJ; Lee, YS; Lizak, MJ; Sato, S; Sinz, A; Tsai, JY	1
Chen, Z; Kador, PF; Lee, YS; Sugiyama, K	1
Rauscher, F; Sanders, R; Thomas, T; Veltman, J; Watkins, JB	1
Fan, W; Hu, Y; Li, G; Yan, M	1
Blessing, K; Fujisawa, S; Kador, PF; Lee, JW; Lou, MF	1
Alam, S; Kador, PF; Murata, M; Ohta, N; Sakurai, S; Sato, S; Tsai, J	1
Kador, PF; Lizak, MJ; Mori, K	1
Jusko, WJ; Mager, DE	1
Barski, OA; Finegold, MJ; Ivanova, MM; Papusha, VZ; Rudman, DM	1
Gianni, L; Menna, P; Minotti, G; Salvatorelli, E	1
Blessing, K; Hamada, T; Kador, PF; Reinhardt, RA	1
Blessing, K; Kador, PF; Marx, DB; O'Meara, JD; Reinhardt, RA	1
Blessing, K; Kador, PF; Makita, J; Randazzo, J; Zhang, P	1
Kador, PF; Zhang, P; Zhang, Z	1

Trials

2 trial(s) available for imirestat and hydantoins

Article	Year
Metabolism of the aldose reductase inhibitor ALO1567 in man. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adult; Aldehyde Reductase; Biotransformation; Double-Blind Method; Fluorenes; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydantoins; Male; Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet	1991
Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients. Journal of clinical pharmacology, 1988, Volume: 28, Issue:8 Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Double-Blind Method; Erythrocytes; Female; Fluorenes; Humans; Hydantoins; Hypoglycemic Agents; Male; Middle Aged; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases	1988

Article

Year

Metabolism of the aldose reductase inhibitor ALO1567 in man.

British journal of clinical pharmacology, 1991, Volume: 32, Issue:2

Topics: Adult; Aldehyde Reductase; Biotransformation; Double-Blind Method; Fluorenes; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydantoins; Male; Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet

1991

Red blood cell sorbitol lowering effects and tolerance of single doses of AL 1576 (HOE 843) in diabetic patients.

Journal of clinical pharmacology, 1988, Volume: 28, Issue:8

Topics: Adolescent; Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Double-Blind Method; Erythrocytes; Female; Fluorenes; Humans; Hydantoins; Hypoglycemic Agents; Male; Middle Aged; Random Allocation; Sorbitol; Sugar Alcohol Dehydrogenases

1988

Other Studies

61 other study(ies) available for imirestat and hydantoins

Article	Year
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition. Neuroscience letters, 1992, Mar-30, Volume: 137, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Fluorenes; Fructose; Glucose; Hydantoins; Inositol; Insulin; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Substance P	1992
Pharmacokinetics and efficacy of structurally related spirohydantoin and spirosuccinimide aldose reductase inhibitors. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:5 Topics: Administration, Oral; Aldehyde Reductase; Animals; Crystallins; Diabetes Mellitus, Experimental; Female; Fluorenes; Hydantoins; Injections, Intravenous; Ketamine; Macaca fascicularis; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Spiro Compounds; Structure-Activity Relationship; Succinimides	1992
Rat kidney aldose reductase and aldehyde reductase and polyol production in rat kidney. The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 2 Topics: Aldehyde Reductase; Animals; Chromatography, Gas; Diet; Female; Fluorenes; Galactitol; Galactose; Hydantoins; Kidney; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol	1992
Application of 19F-n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:7 Topics: Aldehyde Reductase; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Fluorenes; Fluorine; Glucuronates; Hydantoins; Hydrolysis; Magnetic Resonance Spectroscopy; Male	1992
Saturable tissue binding and imirestat pharmacokinetics in rats. Pharmaceutical research, 1992, Volume: 9, Issue:4 Topics: Aldehyde Reductase; Animals; Fluorenes; Hydantoins; Male; Phthalazines; Rats; Rats, Inbred Strains; Tissue Distribution	1992
The possible mechanism of naphthalene cataract in rat and its prevention by an aldose reductase inhibitor (ALO1576). Experimental eye research, 1992, Volume: 54, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Fluorenes; Glutathione; Hydantoins; Lens, Crystalline; Male; Naphthalenes; Rats; Rats, Inbred Strains	1992
Establishment of a naphthalene cataract model in vitro. Experimental eye research, 1992, Volume: 54, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Culture Techniques; Fluorenes; Hydantoins; Lens, Crystalline; Male; Models, Biological; Naphthalenes; Rats; Rats, Inbred Strains	1992
Site-directed mutagenesis of His-42, His-188 and Lys-263 of human aldose reductase. Biochemical and biophysical research communications, 1992, Feb-28, Volume: 183, Issue:1 Topics: Aldehyde Reductase; Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Fluorenes; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Naphthalenes; Structure-Activity Relationship	1992
Effect of osmotic stress on phosphorylcholine efflux and turnover in rat lenses. Experimental eye research, 1992, Volume: 54, Issue:2 Topics: Animals; Choline; Fluorenes; Galactose; Glucose; Hydantoins; Lens, Crystalline; Organ Culture Techniques; Osmotic Pressure; Phospholipids; Phosphorylcholine; Rats; Rats, Inbred Strains; Xylose	1992
Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid excretion by high resolution 1H and 13C NMR spectroscopy. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Aldehyde Reductase; Animals; Carbohydrate Dehydrogenases; Enzyme Induction; Female; Fluorenes; Glucaric Acid; Glucuronates; Glucuronic Acid; Hydantoins; Liver; Magnetic Resonance Spectroscopy; Phenobarbital; Rats; Rats, Inbred Strains	1992
Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia, 1991, Volume: 34, Issue:6 Topics: Action Potentials; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electric Conductivity; Electrophysiology; Fluorenes; Fructose; Glucose; Hydantoins; Hypoxia; Insulin; Male; Neural Conduction; Ouabain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin	1991
Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes. Ophthalmic research, 1991, Volume: 23, Issue:5 Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Disease Models, Animal; Female; Fluorenes; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hydantoins; Lens, Crystalline; Naphthalenes; Organ Size; Quinazolines; Random Allocation; Rats; Rats, Inbred BN	1991
Dose-dependent pharmacokinetics of the aldose reductase inhibitor imirestat in man. Pharmaceutical research, 1991, Volume: 8, Issue:1 Topics: Adult; Aldehyde Reductase; Fluorenes; Half-Life; Humans; Hydantoins; Male; Middle Aged; Models, Biological; Regression Analysis; Tissue Distribution	1991
Polyol accumulation in cultured human lens epithelial cells. Experimental eye research, 1991, Volume: 52, Issue:1 Topics: Aldehyde Reductase; Cells, Cultured; Epithelial Cells; Epithelium; Fluorenes; Galactitol; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron; Microscopy, Phase-Contrast; Polymers; Reference Values; Stereoisomerism; Vacuoles	1991
Capillary gas chromatographic-electron-capture assay for the aldose reductase inhibitor imirestat in lens and plasma. Journal of chromatography, 1991, Apr-19, Volume: 565, Issue:1-2 Topics: Administration, Topical; Aldehyde Reductase; Animals; Chromatography, Gas; Fluorenes; Humans; Hydantoins; Lens, Crystalline; Plasma; Rabbits	1991
Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6 Topics: Aldehyde Reductase; Antioxidants; Ascorbic Acid; Copper; Diabetes Mellitus; Dose-Response Relationship, Drug; Fluorenes; Humans; Hydantoins; Imidazoles; Imidazolidines; Iron; Oxidation-Reduction; Structure-Activity Relationship	1991
Pharmacokinetics of the aldose reductase inhibitor imirestat following topical ocular administration. Pharmaceutical research, 1990, Volume: 7, Issue:2 Topics: Administration, Topical; Aldehyde Reductase; Animals; Biological Availability; Dogs; Eye; Fluorenes; Hydantoins; Hydrogen-Ion Concentration; Rabbits; Sugar Alcohol Dehydrogenases; Tissue Distribution	1990
Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochemical pharmacology, 1990, Sep-01, Volume: 40, Issue:5 Topics: Alcohol Dehydrogenase; Aldehyde Reductase; Animals; Cells, Cultured; Fluorenes; Hydantoins; Isoquinolines; Kidney; Kinetics; Lens, Crystalline; Phthalazines; Pyridazines; Rats; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases	1990
Scintigraphic evaluation of the ocular disposition of 18F-imirestat in rabbits. Pharmaceutical research, 1990, Volume: 7, Issue:11 Topics: Aldehyde Reductase; Animals; Diazonium Compounds; Eye; Fluorenes; Fluorine Radioisotopes; Hydantoins; Rabbits	1990
Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes, 1989, Volume: 38, Issue:10 Topics: Albuminuria; Aldehyde Reductase; Animals; Cardiac Output; Diabetes Mellitus, Experimental; Fluorenes; Glomerular Filtration Rate; Hemodynamics; Hydantoins; Imidazoles; Imidazolidines; Iodine Radioisotopes; Male; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Strontium; Sugar Alcohol Dehydrogenases; Vascular Resistance	1989
Determination of AL01576 concentration in rat lenses and plasma by bioassay for aldose reductase activity measurements. Ophthalmic research, 1989, Volume: 21, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, Gas; Female; Fluorenes; Hydantoins; Lens, Crystalline; Naphthalenes; Rats; Sugar Alcohol Dehydrogenases; Swine	1989
The prevention of biochemical changes in lens, retina, and nerve of galactosemic dogs by the aldose reductase inhibitor AL01576. Journal of ocular pharmacology, 1989,Fall, Volume: 5, Issue:3 Topics: Administration, Oral; Aldehyde Reductase; Analysis of Variance; Animals; Dogs; Fluorenes; Galactitol; Galactose; Galactosemias; Glutathione; Hydantoins; Inositol; Lens, Crystalline; Male; Retina; Sciatic Nerve; Sugar Alcohol Dehydrogenases	1989
Attenuation of phosphoinositidase activity and phosphatidylinositol bisphosphate level of bovine retinal capillary pericytes in high glucose. Experimental eye research, 1989, Volume: 48, Issue:1 Topics: 1-Phosphatidylinositol 4-Kinase; Aldehyde Reductase; Animals; Capillaries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Fluorenes; Glucose; Hydantoins; Inositol; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Retinal Vessels; Sorbitol	1989
Effect of protein binding on the high-performance liquid chromatography of phenytoin and imirestat in human serum by direct injection onto internal surface reversed-phase columns. Analytical chemistry, 1989, May-15, Volume: 61, Issue:10 Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Fluorenes; Humans; Hydantoins; Phenytoin; Protein Binding; Spectrophotometry, Ultraviolet	1989
Stimulation of glucosylated lens epithelial Na,K-ATPase by an aldose reductase inhibitor. Experimental eye research, 1987, Volume: 45, Issue:2 Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cattle; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; Fluorenes; Glucose; Hydantoins; Lens, Crystalline; Potassium; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases	1987
Direct stimulation of Na+-K+-ATPase and its glucosylated derivative by aldose reductase inhibitor. Diabetes, 1987, Volume: 36, Issue:6 Topics: Aldehyde Reductase; Animals; Cattle; Dose-Response Relationship, Drug; Fluorenes; Fluorescein-5-isothiocyanate; Fluoresceins; Glycosylation; Hydantoins; Imidazoles; Imidazolidines; Kidney Medulla; Sodium-Potassium-Exchanging ATPase; Sugar Alcohol Dehydrogenases; Thiocyanates	1987
Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats. Metabolism: clinical and experimental, 1987, Volume: 36, Issue:5 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Humans; Hydantoins; In Vitro Techniques; Kinetics; Lens, Crystalline; Male; Placenta; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases	1987
Disposition of the aldose reductase inhibitor AL01576 in rats. Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:2 Topics: Aldehyde Reductase; Animals; Fluorenes; Hydantoins; Male; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases; Tissue Distribution	1988
Glutathione depletion in the lens of galactosemic and diabetic rats. Experimental eye research, 1988, Volume: 46, Issue:4 Topics: Aldehyde Reductase; Aminoisobutyric Acids; Animals; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Fluorenes; Galactitol; Galactosemias; Glutathione; Glutathione Reductase; Hydantoins; Lens, Crystalline; Male; NAD; NADP; Rats; Rats, Inbred Strains; Sorbitol	1988
AL-1576, an aldose reductase inhibitor (ARI), did not prevent the decrease of norepinephrine turnover in diabetic rats. Research communications in chemical pathology and pharmacology, 1988, Volume: 61, Issue:2 Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Female; Fluorenes; Hydantoins; Lens, Crystalline; Norepinephrine; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases	1988
Effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray cataract. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1988, Volume: 226, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Female; Fluorenes; Hydantoins; Lens, Crystalline; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Sugar Alcohol Dehydrogenases; Ultraviolet Rays	1988
The protein binding of phenytoin, propranolol, diazepam, and AL01576 (an aldose reductase inhibitor) in human and rat diabetic serum. Pharmaceutical research, 1988, Volume: 5, Issue:5 Topics: Adult; Aldehyde Reductase; Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diazepam; Fluorenes; Humans; Hydantoins; Male; Phenytoin; Propranolol; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Sugar Alcohol Dehydrogenases	1988
Serum protein binding of AL01576, a new aldose reductase inhibitor. Pharmaceutical research, 1988, Volume: 5, Issue:5 Topics: Aldehyde Reductase; Blood Proteins; Dialysis; Fluorenes; Humans; Hydantoins; Hydrogen-Ion Concentration; Male; Protein Binding; Sugar Alcohol Dehydrogenases; Ultrafiltration	1988
The effect of non-enzymatic glycation on recombinant human aldose reductase. Diabetes research and clinical practice, 1995, Volume: 27, Issue:3 Topics: Aldehyde Reductase; Enzyme Inhibitors; Fluorenes; Glucose; Glycosylation; Humans; Hydantoins; Imidazoles; Imidazolidines; Kinetics; Naphthalenes; Phthalazines; Recombinant Proteins; Substrate Specificity; Transfection	1995
Permeability of the blood-retinal and blood-aqueous barriers in galactose-fed rats. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3 Topics: Aldehyde Reductase; Animals; Autoradiography; Blood-Aqueous Barrier; Blood-Retinal Barrier; Capillary Permeability; Ciliary Body; Coloring Agents; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Female; Fluorenes; Galactose; Hydantoins; Iris; Microscopy, Fluorescence; Peroxidases; Rats; Rats, Sprague-Dawley; Retinal Vessels; Sucrose	1995
Minimal effects of two aldose reductase inhibitors, AL-1576 and AL-4114, after subacute topical-ocular dosing on xenobiotic biotransformation in rabbits. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10 Topics: Administration, Topical; Aldehyde Reductase; Animals; Biotransformation; Enzyme Inhibitors; Eye; Fluorenes; Hydantoins; Kidney; Liver; Rabbits; Spiro Compounds; Xenobiotics	1995
Inhibition of naphthalene cataract in rats by aldose reductase inhibitors. Current eye research, 1996, Volume: 15, Issue:4 Topics: Aldehyde Reductase; Animals; Cataract; Culture Techniques; Disease Models, Animal; Enzyme Inhibitors; Fluorenes; Galactose; Hydantoins; Imidazoles; Imidazolidines; Male; Naphthalenes; Rats; Spiro Compounds	1996
Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid. Free radical research, 1996, Volume: 25, Issue:4 Topics: 1-Octanol; Aldehyde Reductase; Animals; Ascorbic Acid; Chelating Agents; Copper; Enzyme Activation; Enzyme Inhibitors; Erythrocytes; Fluorenes; Glucose; Humans; Hydantoins; Hydrogen Peroxide; Hyperglycemia; Imidazoles; Imidazolidines; In Vitro Techniques; Ions; Lens, Crystalline; Lipid Peroxidation; NADP; Octanols; Oxidation-Reduction; Phenanthrolines; Rats; Thioctic Acid	1996
Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:1 Topics: Aldehyde Reductase; Animals; Arachidonic Acids; Cell Membrane; Diabetes Mellitus, Experimental; Diglycerides; Enzyme Activation; Fluorenes; Glucose; Hydantoins; Hyperglycemia; In Vitro Techniques; Kidney Glomerulus; Male; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sorbitol; Streptozocin; Time Factors	1997
Aldose reductase as dihydrodiol dehydrogenase. Naphthoquinone formation by rat lens aldose reductase. Advances in experimental medicine and biology, 1997, Volume: 414 Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Eye Proteins; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthoquinones; Oxidoreductases; Phthalazines; Rats	1997
The effects of elevated glucose on Na+/K(+)-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1997, Volume: 13, Issue:4 Topics: Aldehyde Reductase; Animals; Biological Transport; Bumetanide; Cattle; Cells, Cultured; Enzyme Inhibitors; Fluorenes; Glucose; Hydantoins; Hyperglycemia; Ouabain; Pigment Epithelium of Eye; Potassium; Rubidium; Sodium-Potassium-Exchanging ATPase; Strophanthidin	1997
Involvement of aldose reductase in naphthalene cataract. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:1 Topics: Aldehyde Reductase; Animals; Cataract; Culture Media; Disease Progression; Enzyme Inhibitors; Fluorenes; Hydantoins; Lens, Crystalline; Mice; Mice, Transgenic; Naphthols; Organ Culture Techniques	1998
Diabetic-like corneal sensitivity loss in galactose-fed rats ameliorated with aldose reductase inhibitors. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1998, Volume: 14, Issue:2 Topics: Aldehyde Reductase; Animals; Blinking; Cataract; Cornea; Diabetes Mellitus, Experimental; Diet; Enzyme Inhibitors; Fluorenes; Galactose; Galactosemias; Hydantoins; Male; Physical Stimulation; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones	1998
Effect of sorbitol dehydrogenase inhibition on sugar cataract formation in galactose-fed and diabetic rats. Experimental eye research, 1998, Volume: 67, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Galactose; Hydantoins; L-Iditol 2-Dehydrogenase; Phthalazines; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley	1998
3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:13 Topics: Aldehyde Reductase; Animals; Deoxyglucose; Dogs; Enzyme Inhibitors; Epithelial Cells; Fluorenes; Fluorine; Fructose; Gluconates; Hydantoins; Immunoenzyme Techniques; Lens, Crystalline; Magnetic Resonance Spectroscopy; Polymers; Sorbitol	1998
Iris vasculopathy in galactose-fed rats. Experimental eye research, 1999, Volume: 68, Issue:2 Topics: Aldehyde Reductase; Animals; Blood Vessels; Blood-Aqueous Barrier; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Inhibitors; Evans Blue; Female; Fluorenes; Galactose; Horseradish Peroxidase; Hydantoins; Iris; Microscopy, Electron; Permeability; Rats; Rats, Sprague-Dawley	1999
Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Experimental eye research, 1999, Volume: 68, Issue:5 Topics: Aldehyde Reductase; Animals; Cataract; Chromatography, High Pressure Liquid; Crystallins; Enzyme Inhibitors; Fluorenes; Hydantoins; Imidazoles; Imidazolidines; Lens, Crystalline; Naphthalenes; Naphthols; Naphthoquinones; Phthalazines; Rats; Spectrophotometry	1999
Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats. Biochemical pharmacology, 1999, Aug-01, Volume: 58, Issue:3 Topics: Aldehyde Reductase; Animals; Deamination; Enzyme Inhibitors; Fluorenes; Hydantoins; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Sprague-Dawley; Sorbitol; Superior Cervical Ganglion	1999
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4 Topics: Aldehyde Reductase; Animals; Enzyme Inhibitors; Fluorenes; Humans; Hydantoins; Lens, Crystalline; Models, Molecular; Muscles; NADP; Naphthalenes; Phthalazines; Rats	2000
Effects of aldose reductase inhibitors on antioxidant defense in rat and rabbit liver. Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 53, Issue:1 Topics: Aldehyde Reductase; Animals; Antioxidants; Catalase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorenes; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Hydantoins; Lipid Peroxidation; Liver; Male; Oxidative Stress; Oxidoreductases; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Spiro Compounds; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2000
[The role of lens epithelium in cataract formation in diabetic rats]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1998, Volume: 29, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Epithelium; Female; Fluorenes; Hydantoins; Lens, Crystalline; Male; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase	1998
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:2 Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorenes; Glutathione; Glycation End Products, Advanced; Glycosylation; Hydantoins; Lens, Crystalline; Naphthalenes; Phthalazines; Rats; Rats, Sprague-Dawley; Sorbitol; Spectrometry, Fluorescence	2000
The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chemico-biological interactions, 2001, Jan-30, Volume: 130-132, Issue:1-3 Topics: Aldehyde Reductase; Animals; Apoptosis; Base Sequence; Cataract; Cells, Cultured; DNA Primers; Dogs; Enzyme Inhibitors; Epithelial Cells; Fluorenes; Galactitol; Galactose; Hydantoins; Lens, Crystalline; Sugar Alcohols	2001
Determination of aldose reductase activity in the eye by localized magnetic resonance spectroscopy. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2001, Volume: 17, Issue:5 Topics: Aldehyde Reductase; Animals; Deoxyglucose; Enzyme Inhibitors; Fluorenes; Hydantoins; Lens, Crystalline; Magnetic Resonance Spectroscopy; Rabbits; Sorbitol	2001
General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Journal of pharmacokinetics and pharmacodynamics, 2001, Volume: 28, Issue:6 Topics: Bosentan; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Fluorenes; Humans; Hydantoins; Interferon-beta; Male; Models, Chemical; Nonlinear Dynamics; Pharmacokinetics; Sulfonamides	2001
Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. American journal of physiology. Renal physiology, 2005, Volume: 289, Issue:1 Topics: Aldehyde Reductase; Animals; Base Sequence; Cells, Cultured; Fluorenes; Gene Expression Regulation, Developmental; Humans; Hydantoins; Intestinal Mucosa; Kidney Tubules, Proximal; Liver; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Tissue Distribution	2005
Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-taxane chemotherapies. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:2 Topics: Aged; Antineoplastic Agents; Cytosol; Docetaxel; Doxorubicin; Epirubicin; Female; Fluorenes; Heart; Humans; Hydantoins; Hydrogen Peroxide; Male; Middle Aged; Myocardium; Paclitaxel; Reactive Oxygen Species; Taxoids	2007
Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. Postgraduate medicine, 2010, Volume: 122, Issue:3 Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Fluorenes; Hydantoins; Lipopolysaccharides; Male; Maxillary Diseases; Periodontitis; Rats; Rats, Sprague-Dawley; Streptozocin	2010
Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats. Journal of periodontology, 2011, Volume: 82, Issue:6 Topics: Aldehyde Reductase; Alveolar Bone Loss; Animals; Antioxidants; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fluorenes; Glycolysis; Hydantoins; Lipopolysaccharides; Male; Naphthalenes; Periodontitis; Quercetin; Rats; Rats, Sprague-Dawley; Sorbitol	2011
Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats. PloS one, 2011, Apr-26, Volume: 6, Issue:4 Topics: Administration, Oral; Animals; Antioxidants; Body Weight; Cataract; Diabetes Mellitus, Type 1; Disease Progression; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fluorenes; Gamma Rays; Heat-Shock Proteins; Humans; Hydantoins; Hyperglycemia; Lens Capsule, Crystalline; Pigmentation; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Streptozocin; Stress, Physiological	2011
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2014, Volume: 30, Issue:1 Topics: Aldehyde Reductase; Animals; Capillaries; Cell Line; Endothelial Cells; Fluorenes; Galactitol; Galactose; Glucose; Hydantoins; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Naphthalenes; Pericytes; Rats; Rats, Transgenic; Retinal Vessels; Sorbitol	2014