imipramine has been researched along with warfarin in 45 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (15.56) | 18.7374 |
1990's | 4 (8.89) | 18.2507 |
2000's | 17 (37.78) | 29.6817 |
2010's | 15 (33.33) | 24.3611 |
2020's | 2 (4.44) | 2.80 |
Authors | Studies |
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Gubernator, K; Kansy, M; Senner, F | 1 |
Duffy, EM; Jorgensen, WL | 1 |
Topliss, JG; Yoshida, F | 1 |
Faller, B; Wohnsland, F | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Caron, G; Ermondi, G | 1 |
Carrupt, PA; Martel, S; Ottaviani, G | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Gozalbes, R; Pineda-Lucena, A | 1 |
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
Abadi, AH; Abdel-Halim, M; Engel, M; Fathalla, RK; Hammam, MA; Hartmann, RW; Hefnawy, A; Keeton, AB; Maher, A; Maxuitenko, Y; Piazza, GA; Racheed, NAS; Sigler, S | 1 |
d'Athis, P; Lecomte, M; Tillement, JP; Zini, R | 1 |
Bree, F; Durand, G; Gardier, A; Rouzeau, JD; Tillement, JP | 1 |
Fiedler, VB; Göbel, H; Kettenbach, B; Nitz, RE | 1 |
Decker, WJ; Thompson, HL | 1 |
Fossati, C | 1 |
Bickel, MH; Steele, JW | 1 |
Durno, D; Howie, JG; Petrie, JC | 1 |
Duche, JC; Gomas, E; Herve, F; Tillement, JP | 1 |
Obach, RS | 1 |
Gelboin, HV; Gonzalez, FJ; Krausz, KW; Sai, Y; Yang, TJ | 1 |
Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M | 1 |
Flarakos, J; Morand, KL; Vouros, P | 1 |
Arai, S; Kato, M; Kinoshita, H; Nabuchi, Y; Saito, K; Tachibana, T; Uchimura, T | 1 |
Hage, DS; Smith, QR; Yoo, MJ | 1 |
Huang, SD; Jiang, HD; Li, J; Sun, DL; Wu, PS; Ye, YJ | 1 |
Briscoe, CJ; Hage, DS; Mallik, R; Yoo, MJ | 1 |
Bi, C; Clarke, W; Hage, DS; Isingizwe, Z; Matsuda, R; Zhang, C | 1 |
2 review(s) available for imipramine and warfarin
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Halothane; Humans; Imipramine; Liver; Methotrexate; Methyldopa; Nicotinic Acids; Oxacillin; Phenylbutazone; Testosterone; Tetracycline | 1974 |
43 other study(ies) available for imipramine and warfarin
Article | Year |
---|---|
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Topics: Animals; Blood Proteins; Celecoxib; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Female; Half-Life; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2021 |
Phenytoin binding to human albumin.
Topics: Anilino Naphthalenesulfonates; Fatty Acids, Nonesterified; Humans; Imipramine; Palmitic Acids; Phenylbutazone; Phenytoin; Protein Binding; Serum Albumin; Warfarin | 1979 |
Comparison of drug binding capacities of three AAG glycan variants of human origin.
Topics: Dialysis; Estrenes; Humans; Imipramine; Immunodiffusion; Mifepristone; Orosomucoid; Pharmaceutical Preparations; Polysaccharides; Warfarin | 1989 |
Treatment of haemodynamic and electrocardiographic side-effects resulting from imipramine toxicity in rats and dogs.
Topics: Animals; Arrhythmias, Cardiac; Chromonar; Coumarins; Dipyridamole; Dogs; Electrocardiography; Female; Heart Failure; Hemodynamics; Imipramine; Male; Rats | 1985 |
Analysis of blood. A simplified gas chromatographic approach for toxicologic purposes.
Topics: Amitriptyline; Amphetamine; Analgesics; Barbiturates; Chlorothiazide; Chromatography, Gas; Ephedrine; Glutethimide; Histamine H1 Antagonists; Humans; Imipramine; Pharmaceutical Preparations; Phenylpropanolamine; Tranquilizing Agents; Warfarin | 1968 |
Binding of basic and acidic drugs to rat tissue subcellular fractions.
Topics: Animals; Binding Sites; Brain; Cell Nucleus; Chlorpromazine; Imipramine; Kidney; Kinetics; Liver; Lung; Male; Methadone; Microsomes; Mitochondria; Muscles; Organ Specificity; Phenylbutazone; Protein Binding; Rats; Receptors, Drug; Salicylates; Sulfadimethoxine; Warfarin | 1974 |
Awareness and experience of general practitioners of selected drug interactions.
Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Cognition; Dibenzazepines; Drug Interactions; Family Practice; Humans; Hypnotics and Sedatives; Imipramine; Insulin; Monoamine Oxidase Inhibitors; Physicians; Public Opinion; Scotland; Sulfonamides; Surveys and Questionnaires; Tolbutamide; Warfarin | 1974 |
Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycoprotein.
Topics: Genetic Variation; Humans; Imipramine; In Vitro Techniques; Mifepristone; Orosomucoid; Protein Binding; Warfarin | 1993 |
Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
Topics: Animals; Blood Proteins; Cell Line; Dogs; Enzyme Activation; Haplorhini; Humans; Imipramine; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Propranolol; Protein Binding; Rats; Spodoptera; Warfarin | 1997 |
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
Topics: Antibodies, Monoclonal; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Humans; Imipramine; Microsomes, Liver | 1999 |
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes | 2003 |
High-throughput solution-based medicinal library screening against human serum albumin.
Topics: Acecainide; beta-Lactams; Chromatography, Gel; Chromatography, Liquid; Combinatorial Chemistry Techniques; Dansyl Compounds; Humans; Imipramine; Indomethacin; Pharmaceutical Preparations; Protein Binding; Quinidine; Reproducibility of Results; Sarcosine; Serum Albumin; Tandem Mass Spectrometry; Tryptophan; Warfarin | 2005 |
New method for the simultaneous estimation of intrinsic hepatic clearance and protein binding by matrix inhibition.
Topics: Adsorption; Algorithms; Animals; Dialysis; Diazepam; Imipramine; Liver; Metabolic Clearance Rate; Microsomes, Liver; Protein Binding; Proteins; Rats; Serum; Tritium; Warfarin | 2008 |
Studies of imipramine binding to human serum albumin by high-performance affinity chromatography.
Topics: Anticoagulants; Antidepressive Agents, Tricyclic; Binding, Competitive; Chromatography, Affinity; Chromatography, High Pressure Liquid; Humans; Imipramine; Indicators and Reagents; Protein Binding; Receptors, GABA-A; Serum Albumin; Tryptophan; Warfarin | 2009 |
Stereoselective protein binding of tetrahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma.
Topics: Animals; Berberine Alkaloids; Binding, Competitive; Drug Interactions; Humans; Ibuprofen; Imipramine; Male; Mifepristone; Orosomucoid; Plasma; Protein Binding; Rats; Rats, Sprague-Dawley; Serum Albumin; Stereoisomerism; Substrate Specificity; Warfarin | 2010 |
Analysis of drug-protein binding by ultrafast affinity chromatography using immobilized human serum albumin.
Topics: Chromatography, Affinity; Humans; Ibuprofen; Imipramine; Immobilized Proteins; Kinetics; Protein Binding; Serum Albumin; Warfarin | 2010 |
Studies of drug interactions with alpha
Topics: Antibodies; Chlorpromazine; Chromatography, Affinity; Disopyramide; Drug Interactions; Humans; Imipramine; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Warfarin | 2017 |