imipramine and trazodone

imipramine has been researched along with trazodone in 109 studies

Research

Studies (109)

Timeframe	Studies, this research(%)	All Research%
pre-1990	69 (63.30)	18.7374
1990's	16 (14.68)	18.2507
2000's	15 (13.76)	29.6817
2010's	9 (8.26)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Abdelkader, MA; Alhaider, AA; Lien, EJ	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Gozalbes, R; Pineda-Lucena, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Lisciani, R; Silvestrini, B	1
Campana, A; Lisciani, R; Scorza Barcellona, P	1
Enjalbert, M; Hamet, P; Larochelle, P	1
Kellams, JJ; Klapper, MH; Small, JG	1
Maj, J; Palider, W	1
Byrne, JE; Deitchman, D; Gomoll, AW	1
Baldini, A; Ciottoli, GB; Lisciani, R	1
Byrne, JE; Gomoll, AW	2
Muronová, J; Topiar, A; Vinar, O	1
Baldini, A; Barcellona, PS; Benedetti, D; Campana, A; Lisciani, R	1
Dalton, J; Karniol, IG; Lader, M	1
Fujita, T; Takahashi, T; Yamato, C	1
Brignone, A; Genco, S; Puca, FM; Serlenga, L; Specchio, LM	1
Belousov, IuB; Brusov, OS; Faktor, MI; Katasonov, AB; Krivonkin, KIu; Zlobina, GP	1
Alhaider, AA	4
Bobkova, NV; Gurevich, EV; Katkov, YA; Nesterova, IV; Otmakhova, NA	2
Patten, SB	1
Alhaider, AA; Mustafa, AA	1
Kafka, MP	1
Bradshaw, CM; Shah, K; Szabadi, E	1
Beljaew, BS; Brusow, OS; Faktor, MI; Katasonow, AB; Larionowa, TB; Lidemann, RR; Slobina, GP; Trunte, K	1
Dall'Olio, R; Gandolfi, O; Roncada, P	1
Dave, V; Mackenzie-Taylor, D; Rech, RH; Shukla, R	1
Boschmans, SA; Opie, LH; Perkin, MF; Terblanche, SE	1
Beliaev, BS; Brusov, OS; Faktor, MI; Katasonov, AB; Zlobina, GP	1
Hara, H; Ikegami, A; Ito, K; Maeda, A; Sukamoto, T; Yamashita, A	1
Cardamone, J; Cook, PE; Dermer, SW	1
Adkins, WN; Eichelman, B; O'Neil, M; Page, N	1
Agnoli, A	1
Boschmans, SA; Perkin, MF; Terblanche, SE	1
Asberg, M; Eriksson, B; Mårtensson, B; Träskman-Bendz, L; Wägner, A	1
Hrdina, PD	1
Lapierre, Y; Mehta, G; Surphlis, W; Telner, J	1
Poshivalov, VP; Valdman, AV	1
Aiken, B; Charney, DS; Goodman, WK; Heninger, GR; Kinch, M; Quadrino, LM; Rifkin, B; Woods, SW	1
Cohen, BM; Lipinski, JF; Zubenko, GS	1
Feighner, JP	3
Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF	1
Schachter, D; Schibuk, M	1
Kalin, NH; Wamboldt, MZ; Weiler, SJ	1
Haggerty, JJ; Jackson, R	1
Karelson, EI; Tarve, US; Tiakhepyl'd, LIa	1
Silvestrini, B; Valeri, P	1
Bush, D; Georgotas, A; Gershon, S; Newton, R	1
Al-Yassiri, MM; Ankier, SI; Bridges, PK	1
Fabre, LF; Feighner, JP	1
Fairbanks, L; Gerner, RH; Hayes, RL; Moran, M; Waltuch, L	1
Gershon, S	1
Kane, JM; Lieberman, J	1
Gold, MS; Lydiard, RB; Pottash, AL	1
Alvarez, FJ; Carvajal, A; Dueñas, A; González, JL; Velasco Martín, A	1
Passarelli, F; Scotti de Carolis, A	1
Enna, SJ; Kendall, DA; Taylor, DP	1
Shopsin, B	1
Al-Yassiri, MM; Bridges, PK	1
Avery, GS; Brogden, RN; Heel, RC; Speight, TM	1
Wheatley, D	1
Georgotas, A; Gershon, S; Mann, JJ; Newton, R	1
Silvestrini, B	1
Cassano, GB; Conti, L; Dell'Osso, L; Massimetti, G	1
Burgess, CD; George, CF; Hames, TK	2
Avdulov, NA; Maĭsov, NI	1
Friedman, E; Georgotas, A; Gershon, S; Mann, JJ	1
Gershon, S; Newton, R	1
Estabrook, W; Gerner, R; Jarvik, L; Steuer, J	1
Estabrook, W; Gerner, R; Jarvik, L; Kakkar, P; Steuer, J; Waltuch, L	1
Klein, DF	1
Peterová, E; Pisl, I; Vencovský, E	1
Bastide, P; Coudert, P; Rubat, C; Tronche, P	1
Balon, R	1
Downing, R; Hassman, H; Rickels, K; Schweizer, E	1
Short, DD; Workman, EA	1
Hatsuda, S; Matsubara, M; Miura, K; Murakami, H; Nakazawa, K; Ohara, M; Sugita, S; Suzuki, S; Terashima, M	1
Endo, S; Nakamura, S; Suzuki, H; Yamadera, H	3
Casis, O; Sánchez-Chapula, JA	1
Hatsuda, S; Hayashi, T; Kimura, H; Matsubara, M; Miura, K; Mori, T; Murakami, H; Ohara, M; Ohta, T; Sugita, S; Suzuki, S; Terashima, M	1
Hatsuda, S; Kayukawa, Y; Matsubara, M; Ohara, M; Ozaki, N; Sugita, S; Suzuki, S	1
Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM	1
Abdel-Salam, OM; Arbid, MS; Baiuomy, AR	1
Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G	1
Ikenouchi-Sugita, A; Nakamura, J; Yoshimura, R	1

Reviews

10 review(s) available for imipramine and trazodone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The comparative efficacy of trazodone and imipramine in the treatment of depression. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1992, Apr-01, Volume: 146, Issue:7 Topics: Clinical Trials as Topic; Confidence Intervals; Depressive Disorder; Humans; Imipramine; Meta-Analysis as Topic; Research Design; Therapeutic Equivalency; Trazodone; Treatment Outcome	1992
Antidepressant drugs: imipramine, mianserin and trazodone. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1987, Volume: 86, Issue:2 Topics: Animals; Antidepressive Agents; Biotransformation; Humans; Imipramine; Mianserin; Receptors, Drug; Trazodone	1987
Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry, 1986, Volume: 47 Suppl Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imipramine; Oximes; Paroxetine; Piperidines; Propylamines; Serotonin; Serotonin Antagonists; Trazodone; Zimeldine	1986
The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Anthracenes; Clinical Trials as Topic; Depression; Dibenzoxazepines; Humans; Imipramine; Maprotiline; Piperazines; Time Factors; Trazodone	1984
Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 1981, Volume: 21, Issue:6 Topics: Aged; Animals; Anxiety Disorders; Brain; Cardiovascular System; Clinical Trials as Topic; Depressive Disorder; Humans; Imipramine; Kinetics; Middle Aged; Piperazines; Schizophrenia; Trazodone	1981
Trazodone--a new type of antidepressant: a discussion of pharmacological data and their clinical implications. Advances in biochemical psychopharmacology, 1982, Volume: 31 Topics: Animals; Brain; Depression; Humans; Imipramine; Piperazines; Receptors, Serotonin; Trazodone	1982
Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Antidepressive Agents; Benzeneacetamides; Clinical Trials as Topic; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Mianserin; Middle Aged; Nomifensine; Oxazines; Psychiatric Status Rating Scales; Trazodone	1982
Atypical antidepressants versus imipramine in the treatment of major depression: a meta-analysis. The Journal of clinical psychiatry, 1993, Volume: 54, Issue:1 Topics: Antidepressive Agents; Bupropion; Depressive Disorder; Fluoxetine; Humans; Imipramine; Trazodone	1993
[Review of pharmacological efficacies and side effects of antidepressants]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Volume: 65, Issue:9 Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Fluvoxamine; Humans; Imipramine; Maprotiline; Paroxetine; Sulpiride; Trazodone	2007

Trials

22 trial(s) available for imipramine and trazodone

Article	Year
Responses to tyramine and norepinephrine after imipramine and trazodone. Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:1 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Synergism; Humans; Imipramine; Norepinephrine; Piperazines; Placebos; Trazodone; Tyramine	1979
Trazodone, a new antidepressant: efficacy and safety in endogenous depression. The Journal of clinical psychiatry, 1979, Volume: 40, Issue:9 Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Social Behavior; Trazodone	1979
Effects of antidepressants on thinking styles in depressed inpatients. Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:2-3 Topics: Adult; Antidepressive Agents; Clinical Trials as Topic; Cognition; Female; Fluoxetine; Humans; Imipramine; Male; Mood Disorders; Personality Tests; Thinking; Trazodone	1988
Drug treatment of panic disorder: the comparative efficacy of imipramine, alprazolam, and trazodone. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:12 Topics: Agoraphobia; Alprazolam; Anxiety Disorders; Clinical Trials as Topic; Fear; Humans; Imipramine; Panic; Patient Dropouts; Psychiatric Status Rating Scales; Time Factors; Trazodone	1986
[Review of studies of trazodone at the Feighner Research Institute in ambulatory and hospitalized patients]. L'Encephale, 1986, Volume: 12 Spec No Topics: Adolescent; Adult; Aged; Ambulatory Care; Depressive Disorder; Double-Blind Method; Female; Hospitalization; Humans; Imipramine; Male; Middle Aged; Random Allocation; Trazodone	1986
Clinical evaluation of two new antidepressants. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Pyridines; Trazodone; Zimeldine	1982
A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression. Journal of affective disorders, 1983, Volume: 5, Issue:4 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Psychometrics; Trazodone	1983
Long-term therapy for depression with trazodone. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:1 Topics: Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Piperazines; Psychiatric Status Rating Scales; Random Allocation; Trazodone	1983
ECG findings in geriatric depressives given trazodone, placebo, or imipramine. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Imipramine; Male; Piperazines; Placebos; Trazodone	1983
Comparative side effect profiles of trazodone and imipramine: special reference to the geriatric population. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Humans; Imipramine; Mental Recall; Piperazines; Psychiatric Status Rating Scales; Receptors, Cholinergic; Retention, Psychology; Trazodone	1984
The efficacy of amoxapine, maprotiline, and trazodone in comparison to imipramine and amitriptyline: a review of the literature. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Anthracenes; Clinical Trials as Topic; Depression; Dibenzoxazepines; Humans; Imipramine; Maprotiline; Piperazines; Time Factors; Trazodone	1984
Speed of onset of action of the newer antidepressants. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Antidepressive Agents; Clinical Trials as Topic; Depression; Depressive Disorder; Double-Blind Method; Humans; Imipramine; Maprotiline; Time Factors; Trazodone	1984
Trazodone in major affective disorders. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Long-Term Care; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Trazodone	1984
Trazodone, a triazolopyridine derivative, in primary depressive disorder. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:7 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Placebos; Psychiatric Status Rating Scales; Trazodone	1980
Trazodone efficacy and safety in endogenous depression: a double blind comparison with imipramine. Neuropharmacology, 1980, Volume: 19, Issue:12 Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Trazodone	1980
Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 1981, Volume: 21, Issue:6 Topics: Aged; Animals; Anxiety Disorders; Brain; Cardiovascular System; Clinical Trials as Topic; Depressive Disorder; Humans; Imipramine; Kinetics; Middle Aged; Piperazines; Schizophrenia; Trazodone	1981
Trazodone in depression. International pharmacopsychiatry, 1980, Volume: 15, Issue:4 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Sleep Stages; Trazodone	1980
A controlled study of trazodone, imipramine, and placebo in outpatients with endogenous depression. Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:2 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Placebos; Psychiatric Status Rating Scales; Time Factors; Trazodone	1981
Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Antidepressive Agents; Benzeneacetamides; Clinical Trials as Topic; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Mianserin; Middle Aged; Nomifensine; Oxazines; Psychiatric Status Rating Scales; Trazodone	1982
Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:6 Topics: Aged; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Trazodone	1980
Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam. Archives of general psychiatry, 1993, Volume: 50, Issue:11 Topics: Adult; Aged; Anxiety Disorders; Diazepam; Double-Blind Method; Drug Administration Schedule; Female; Humans; Imipramine; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Trazodone; Treatment Outcome	1993
Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects. Psychiatry and clinical neurosciences, 1998, Volume: 52, Issue:4 Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Humans; Imipramine; Male; Polysomnography; Sleep; Trazodone	1998

Other Studies

80 other study(ies) available for imipramine and trazodone

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Design, synthesis, and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:10 Topics: Animals; Antidepressive Agents; Body Temperature Regulation; Chemical Phenomena; Chemistry; Lethal Dose 50; Magnetic Resonance Spectroscopy; Mice; Quinolines; Structure-Activity Relationship	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms. Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:5 Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, Inbred Strains; Nicotine; Oxotremorine; Parkinson Disease, Secondary; Phenoxybenzamine; Piloerection; Pyrilamine; Rabbits; Salivation; Sympathetic Nervous System; Trazodone; Tremor	1976
Comparative cardiovascular toxicity of trazodone and imipramine in the rat. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1978, Issue:1 Topics: Animals; Blood Pressure; Cardiovascular Diseases; Dose-Response Relationship, Drug; Electrocardiography; Female; Imipramine; Male; Piperazines; Rats; Trazodone	1978
Trazodone, a central serotonin antagonist and agonist. Journal of neural transmission, 1979, Volume: 44, Issue:3 Topics: Animals; Cyproheptadine; Dose-Response Relationship, Drug; Fenfluramine; Imipramine; Lysergic Acid Diethylamide; Male; Piperazines; Quipazine; Rats; Reflex; Serotonin; Serotonin Antagonists; Trazodone; Triazoles	1979
Hemodynamic and cardiac actions of trazodone and imipramine in the anesthetized dog. Life sciences, 1979, May-14, Volume: 24, Issue:20 Topics: Animals; Blood Pressure; Dogs; Female; Heart Rate; Imipramine; Male; Myocardial Contraction; Phentolamine; Piperazines; Regional Blood Flow; Trazodone	1979
Behavioral study on the interactions between trazodone and L-dopa. Pharmacological research communications, 1979, Volume: 11, Issue:3 Topics: Animals; Behavior, Animal; Drug Interactions; Female; Haloperidol; Imipramine; Levodopa; Male; Mice; Muscle Rigidity; Piperazines; Time Factors; Trazodone	1979
Trazodone and imipramine: comparative effects on canine cardiac conduction. European journal of pharmacology, 1979, Aug-15, Volume: 57, Issue:4 Topics: Animals; Blood Pressure; Bundle of His; Dogs; Electrocardiography; Female; Heart Conduction System; Heart Rate; Imipramine; In Vitro Techniques; Male; Piperazines; Trazodone	1979
Trazodone in depressions. Activitas nervosa superior, 1979, Volume: 21, Issue:3 Topics: Depression; Double-Blind Method; Humans; Imipramine; Piperazines; Trazodone	1979
Acute cardiovascular toxicity of trazodone, etoperidone and imipramine in rats. Toxicology, 1978, Volume: 10, Issue:2 Topics: Animals; Blood Pressure; Electrocardiography; Female; Heart Rate; Hemodynamics; Imipramine; Male; Piperazines; Rats; Trazodone	1978
Comparative psychotropic effects of trazodone, imipramine and diazepam in normal subjects. Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:3 Topics: Acoustic Stimulation; Adult; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Evoked Potentials; Female; Galvanic Skin Response; Humans; Imipramine; Male; Piperazines; Placebos; Psychotropic Drugs; Pupil; Task Performance and Analysis; Trazodone; Tremor	1976
Studies on metabolism of trazodone. IV. Intestinal absorption in rats and rabbits. Xenobiotica; the fate of foreign compounds in biological systems, 1976, Volume: 6, Issue:9 Topics: Animals; Catheterization; Duodenum; Fasting; Gastric Mucosa; Imipramine; Intestinal Absorption; Intestine, Small; Male; Organ Specificity; Piperazines; Pylorus; Rabbits; Rats; Trazodone; Veins	1976
[Modifications induced by antidepressant drugs on the vestibulo-ocular reflex in man]. Bollettino della Societa italiana di biologia sperimentale, 1975, Oct-30, Volume: 51, Issue:20 Topics: Amitriptyline; Antidepressive Agents; Eye Movements; Humans; Imipramine; Nortriptyline; Phenelzine; Reflex; Reflex, Oculocardiac; Trazodone; Vestibule, Labyrinth	1975
[Function of the serotoninergic system of blood platelets in patients with hypertension]. Kardiologiia, 1992, Volume: 32, Issue:11-12 Topics: Blood Flow Velocity; Blood Platelets; Female; Humans; Hypertension; Imipramine; Male; Middle Aged; Receptors, Serotonin; Serotonin; Trazodone	1992
New hybrids of quipazine and trazodone as selective inhibitors of uptake of 5-hydroxytryptamine. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:1 Topics: Animals; Cerebral Cortex; Cyclic AMP; Female; Imipramine; Isoproterenol; Lethal Dose 50; Male; Mice; Motor Activity; Norepinephrine; Piperazines; Pyridones; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin; Synaptosomes; Trazodone	1992
Dissociation of multiple behavioral effects between olfactory bulbectomized C57Bl/6J and DBA/2J mice. Physiology & behavior, 1992, Volume: 52, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Olfactory Bulb; Trazodone	1992
Enhancement of imipramine-induced rat brain beta-adrenoreceptor desensitization by subacute co-administration of trazodone, zimelidine, quipazine or 5-hydroxytryptophan. Psychopharmacology, 1991, Volume: 103, Issue:3 Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Drinking Behavior; Female; Fenclonine; Imipramine; Isoproterenol; Ketanserin; Methysergide; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists; Trazodone; Zimeldine	1991
Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men. The Journal of clinical psychiatry, 1991, Volume: 52, Issue:2 Topics: Adult; Antidepressive Agents; Depressive Disorder; Fluoxetine; Humans; Imipramine; Lithium; Male; Masturbation; Middle Aged; Paraphilic Disorders; Psychiatric Status Rating Scales; Sexual Behavior; Sexual Dysfunctions, Psychological; Trazodone	1991
Interaction between antidepressants and d-amphetamine on variable-interval performance. Psychopharmacology, 1990, Volume: 100, Issue:4 Topics: Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Fluvoxamine; Imipramine; Oximes; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule; Serotonin Antagonists; Trazodone	1990
[The effect of imipramine and trazodone on the re-uptake of (3H) serotonin by thrombocytes in patients with endogenous depression: changes in antidepressive therapy]. Psychiatrie, Neurologie, und medizinische Psychologie, 1989, Volume: 41, Issue:4 Topics: Adolescent; Adult; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Middle Aged; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Trazodone	1989
Effects of repeated trazodone administrations on serotonergic neurotransmission: biochemical studies. Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:6 Topics: Animals; Antidepressive Agents; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Imipramine; Kinetics; Male; Mianserin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin; Synaptic Membranes; Synaptic Transmission; Trazodone	1989
Disruption of FR-40 by 5-HT agonists. I. Effects of chronic imipramine or trazodone. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:2 Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reinforcement, Psychology; Trazodone	1989
The effects of imipramine, mianserin and trazodone on the chronotropic, inotropic and coronary vascular responses in the isolated perfused rat heart. General pharmacology, 1989, Volume: 20, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Coronary Circulation; Electrocardiography; Heart Rate; Imipramine; In Vitro Techniques; Male; Mianserin; Myocardial Contraction; Rats; Trazodone	1989
[Sensitivity of the retrograde uptake of H3-serotonin to imipramine and trazodone in patients with endogenous depression treated with antidepressive drugs]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1989, Volume: 89, Issue:2 Topics: Adolescent; Adult; Antidepressive Agents; Bipolar Disorder; Blood Platelets; Culture Media; Depressive Disorder; Drug Interactions; Female; Humans; Imipramine; In Vitro Techniques; Middle Aged; Serotonin; Serotonin Antagonists; Trazodone; Tritium	1989
[Effect of trazodone (KB-831) and its metabolites on brain monoamines in rat]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1989, Volume: 93, Issue:3 Topics: Animals; Biogenic Monoamines; Brain; Depression, Chemical; Imipramine; Male; Mianserin; Rats; Rats, Inbred Strains; Synaptosomes; Trazodone	1989
Antihistamine, anticholinergic and cardiovascular effects of 2-substituted-4-phenylquinoline derivatives. Life sciences, 1986, Feb-17, Volume: 38, Issue:7 Topics: Acetylcholine; Animals; Body Temperature; Cardiovascular System; Electrocardiography; Guinea Pigs; Heart; Heart Rate; Histamine; Histamine H1 Antagonists; Ileum; Imipramine; Muscle Contraction; Parasympatholytics; Rabbits; Reserpine; Trazodone	1986
Imipramine-flupenthixol decanoate interaction. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Desipramine; Drug Interactions; Flupenthixol; Humans; Imipramine; Male; Schizophrenia, Paranoid; Thioxanthenes; Trazodone	1986
Tryptophan-trazodone treatment of aggressive behaviour. Lancet (London, England), 1986, Oct-11, Volume: 2, Issue:8511 Topics: Adult; Aggression; De Lange Syndrome; Drug Therapy, Combination; Humans; Imipramine; Male; Trazodone; Tryptophan	1986
[History and pharmacology of trazodone]. L'Encephale, 1986, Volume: 12 Spec No Topics: Analgesics; Animals; Brain; Depressive Disorder; Drug Therapy, Combination; Humans; Imipramine; Neurotransmitter Agents; Rats; Trazodone	1986
Desensitization of beta-adrenoceptors following repeated injections of 2-substituted 4-phenylquinolines. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:9 Topics: Animals; Brain; Cyclic AMP; Imipramine; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Trazodone	1987
Inhibition of sodium-dependent [3H]imipramine binding in rat brain by serotonin and serotonin uptake inhibitors. European journal of pharmacology, 1988, Mar-29, Volume: 148, Issue:2 Topics: Animals; Cell Membrane; Cerebral Cortex; Clomipramine; Fluoxetine; Imipramine; Male; Rats; Receptors, Serotonin; Serotonin; Sodium; Trazodone	1988
Pharmaco-ethological analysis of antidepressant drug effects. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:3 Topics: Aggression; Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Fluoxetine; Imipramine; Iproniazid; Male; Mice; Motor Activity; Reserpine; Social Behavior; Trazodone	1986
Antidepressant-related akathisia. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:4 Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Female; Humans; Imipramine; Male; Middle Aged; Trazodone	1987
Acute effects of antidepressants on hippocampal seizures. Annals of neurology, 1985, Volume: 18, Issue:6 Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hippocampus; Imipramine; Maprotiline; Propiophenones; Rats; Trazodone	1985
A role for catecholamines in the pathogenesis of neuroleptic malignant syndrome. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:1 Topics: Akathisia, Drug-Induced; Brain Chemistry; Catecholamines; Chlorpromazine; Haloperidol; Humans; Imipramine; Male; Middle Aged; Neuroleptic Malignant Syndrome; Receptors, Dopamine; Trazodone	1986
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Nortriptyline; Trazodone	1985
Mania following change from trazodone to imipramine. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:6 Topics: Adult; Bipolar Disorder; Depression; Female; Humans; Imipramine; Middle Aged; Trazodone	1985
[Effect of psychotropic drugs on cerebral Ca-activated ATPase in vitro]. Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:5 Topics: Amphetamine; Animals; Benactyzine; Brain; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Chlorpromazine; Guinea Pigs; Haloperidol; Imipramine; In Vitro Techniques; Perphenazine; Psychotropic Drugs; Trazodone	1981
Trazodone, a new avenue in the treatment of depression. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Alcohol Withdrawal Delirium; Brain; Depressive Disorder; Humans; Imipramine; Neurotransmitter Agents; Piperazines; Receptors, Neurotransmitter; Synaptic Transmission; Trazodone	1984
[Comparative analysis of trazodone and imipramine against acetylcholine and electrical stimulation in the isolated guinea pig ileum]. Archivos de farmacologia y toxicologia, 1983, Volume: 9, Issue:3 Topics: Acetylcholine; Animals; Electric Stimulation; Female; Guinea Pigs; Ileum; Imipramine; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperazines; Trazodone	1983
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat. Neuropharmacology, 1983, Volume: 22, Issue:6 Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalography; Electroshock; Humans; Imipramine; Male; Piperazines; Rats; Rats, Inbred Strains; Trazodone	1983
[3H]tetrahydrotrazodone binding. Association with serotonin binding sites. Molecular pharmacology, 1983, Volume: 23, Issue:3 Topics: Animals; Brain; Cattle; Cell Membrane; Cerebral Cortex; Imipramine; Kinetics; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Substrate Specificity; Tissue Distribution; Trazodone; Tritium	1983
Second generation antidepressants. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:12 Pt 2 Topics: Antidepressive Agents, Tricyclic; Catecholamines; Depressive Disorder; Double-Blind Method; Fluoxetine; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nomifensine; Serotonin; Trazodone	1980
Hemodynamic responses of trazodone and imipramine. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:4 Topics: Adult; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Imipramine; Male; Piperazines; Stroke Volume; Systole; Trazodone	1982
The electrocardiographic and anticholinergic effects of trazodone and imipramine in man. European journal of clinical pharmacology, 1982, Volume: 23, Issue:5 Topics: Adult; Desipramine; Electrocardiography; Humans; Imipramine; Male; Parasympatholytics; Piperazines; Salivation; Time Factors; Trazodone	1982
Differential effects of trazodone and imipramine on intracardiac conduction in the anesthetized dog. Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:2 Topics: Anesthesia; Animals; Dogs; Electrocardiography; Female; Heart Conduction System; Heart Rate; Imipramine; Male; Piperazines; Trazodone	1982
[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:11 Topics: Animals; Antidepressive Agents; Brain; Carbazoles; Carbolines; Clomipramine; Depression, Chemical; Desipramine; gamma-Aminobutyric Acid; Imipramine; In Vitro Techniques; Oxazines; Piperazines; Rats; Serotonin; Synaptosomes; Trazodone	1981
The antidepressant effects of trazodone and inhibition of platelet serotonin reuptake. Communications in psychopharmacology, 1980, Volume: 4, Issue:4 Topics: Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Humans; Imipramine; In Vitro Techniques; Piperazines; Psychiatric Status Rating Scales; Serotonin; Trazodone	1980
Lack of anticholinergic side effects with a new antidepressent--trazodone. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:3 Topics: Adult; Aged; Constipation; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Receptors, Cholinergic; Trazodone; Urination Disorders; Visual Acuity; Xerostomia	1980
A placebo-controlled double-blind study of imipramine and trazodone in geriatric depression. Proceedings of the annual meeting of the American Psychopathological Association, 1980, Volume: 69 Topics: Age Factors; Aged; Depression; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Personality Inventory; Piperazines; Placebos; Psychological Tests; Sex Factors; Trazodone	1980
Clinical and biological aspects of depression in the elderly. Proceedings of the annual meeting of the American Psychopathological Association, 1980, Volume: 69 Topics: Aged; Dementia; Depression; Doxepin; Humans; Imipramine; Methylphenidate; Middle Aged; Trazodone	1980
[Comparison of antidepressant action of trazodon and imipramine (author's transl)]. Ceskoslovenska psychiatrie, 1980, Volume: 76, Issue:3 Topics: Adult; Depressive Disorder; Humans; Imipramine; Middle Aged; Piperazines; Trazodone	1980
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:2 Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine	1995
Sleep terror disorder and insomnia treated with trazodone: a case report. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1994, Volume: 6, Issue:3 Topics: Child; Female; Humans; Hydroxyzine; Imipramine; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Thioridazine; Trazodone; Treatment Outcome	1994
Anticholinergic, antihistaminic and cardiovascular effects of two new congeners of quipazine and trazodone. Arzneimittel-Forschung, 1993, Volume: 43, Issue:11 Topics: Animals; Blood Pressure; Cardiovascular Agents; Electrocardiography; Female; Guinea Pigs; Histamine H1 Antagonists; Imipramine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Parasympatholytics; Quipazine; Rabbits; Receptors, Serotonin; Trazodone	1993
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice. Physiology & behavior, 1994, Volume: 56, Issue:3 Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disease Models, Animal; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Olfactory Bulb; Smell; Species Specificity; Trazodone	1994
[A study of the effects of antidepressants on the GABAA receptor and its complex based on the drug actions on the power-spectral changes of rat hippocampal EEG induced by GABA antagonists and inverse agonists]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1997, Volume: 17, Issue:2 Topics: Animals; Antidepressive Agents; Carbolines; Depression, Chemical; Desipramine; Electroencephalography; Fluoxetine; GABA Antagonists; Hippocampus; Imipramine; Male; Norepinephrine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Trazodone	1997
Mechanism of block of cardiac transient outward K+ current (I(to)) by antidepressant drugs. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4 Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Binding Sites; Dose-Response Relationship, Drug; Drug Interactions; Heart Ventricles; Imipramine; Maprotiline; Mianserin; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Structure-Activity Relationship; Trazodone; Ventricular Function	1998
Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes. Neuropsychobiology, 2000, Volume: 42, Issue:3 Topics: Animals; Antidepressive Agents; Desipramine; Electroencephalography; Fluoxetine; Fourier Analysis; GABA Antagonists; Hippocampus; Imipramine; Male; Nortriptyline; Pentylenetetrazole; Rats; Rats, Wistar; Trazodone	2000
Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone. Neuropsychobiology, 2001, Volume: 44, Issue:2 Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Imipramine; Male; Microdialysis; Neostriatum; Potassium; Rats; Rats, Wistar; Serotonin; Trazodone	2001
[Chronobiological research on antidepressant drugs: the effect of the antidepressant drugs, trazodone and imipramine on the circadian rhythm using electroencephalography in healthy volunteers]. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2002, Volume: 69, Issue:3 Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Circadian Rhythm; Electroencephalography; Humans; Imipramine; Male; Sleep; Trazodone	2002
Effects of trazodone and imipramine on the biological rhythm: an analysis of sleep EEG and body core temperature. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2002, Volume: 69, Issue:4 Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Body Temperature; Electroencephalography; Humans; Imipramine; Male; Periodicity; Sleep; Trazodone	2002
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacological research, 2003, Volume: 48, Issue:2 Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Imipramine; Inflammation; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sertraline; Trazodone	2003
Studies on the anti-inflammatory effect of fluoxetine in the rat. Pharmacological research, 2004, Volume: 49, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Edema; Fluoxetine; Foot; Imipramine; Indomethacin; Inflammation; Lactones; Melatonin; Pyrazoles; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Time Factors; Trazodone	2004
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose? European journal of clinical pharmacology, 2004, Volume: 60, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride	2004