imipramine has been researched along with propranolol in 204 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 100 (49.02) | 18.7374 |
| 1990's | 33 (16.18) | 18.2507 |
| 2000's | 29 (14.22) | 29.6817 |
| 2010's | 35 (17.16) | 24.3611 |
| 2020's | 7 (3.43) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Caflisch, A; Dong, J; Kolb, P; Lafleur, K; Liebl, J; Nevado, C; Unzue, A; Zahler, S; Zhao, H; Zhou, T | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Alam, MA; Drewes, LR; Gurrapu, S; Jonnalagadda, SK; Lueth, EA; Mereddy, VR; Nelson, GL; Ronayne, CT; Solano, LN | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Handzlik, J; Jankowska, A; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Kurczab, R; Nitek, W; Partyka, A; Satała, G; Siwek, A; Wesołowska, A; Żesławska, E | 1 |
| Abouf, M; Abutaleb, NS; Chen, L; Elsebaei, MM; Ghiaty, A; Hegazy, YA; Malwal, SR; Mayhoub, AS; Mohammad, H; Oldfield, E; Seleem, MN; Zhang, J | 1 |
| Bucki, A; Chrzanowska, A; Czopek, A; Drop, M; Głuch-Lutwin, M; Kołaczkowski, M; Partyka, A; Pawłowski, M; Pękala, E; Siwek, A; Struga, M; Wesołowska, A; Zagórska, A | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Abutaleb, NS; Alhashimi, M; Kassab, AE; Mayhoub, AS; Mohamed, KO; Seleem, MN; Shahin, IG; Taher, AT | 1 |
| Abadi, AH; Abdel-Halim, M; Engel, M; Fathalla, RK; Hammam, MA; Hartmann, RW; Hefnawy, A; Keeton, AB; Maher, A; Maxuitenko, Y; Piazza, GA; Racheed, NAS; Sigler, S | 1 |
| Bach, A; Brambilla, R; Carmona, RMC; Desu, HL; Gajhede, M; Garcia, AD; Høj, LJ; Johansen, TN; Marseglia, G; Munafò, F; Narayanan, D; Pallesen, JS; Popowicz, GM; Sattler, M; Solbak, SMØ; Sørensen, LME; Tran, KT | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Consoli, V; D'Agata, V; D'Amico, AG; Fallica, AN; Floresta, G; Intagliata, S; Pittalà, V; Rescifina, A; Romeo, G; Salerno, L; Sorrenti, V; Vanella, L | 1 |
| Jyujo, T; Sato, T | 2 |
| Elvidge, JA; Jones, JR; Saljoughian, M | 1 |
| Delini-Stula, A; Radeke, E; Vassout, A | 1 |
| Gershon, S; Hine, B; Wallach, MB | 1 |
| Bhattacharya, SK; Das, PK; Mukhopadhyay, SN; Reddy, PK | 1 |
| Caine, M; Raz, S | 1 |
| Gonick, P; Heber, D; Khanna, OP | 1 |
| Drew, R; Gram, TE; Siddik, ZH | 1 |
| Chiba, S; Furukawa, Y; Kobayashi, M | 2 |
| Courtney, KR; Jensen, RA; Malik, R | 2 |
| Francès, H; Lecrubier, Y; Puech, AJ; Simon, P; Souto, M | 1 |
| Strumeliev, S | 1 |
| Bhaskar, EA; Bhaskar, PA; Jagannathan, K | 1 |
| Banaszkiewicz, W; Grzymislawska, I; Mrozikiewicz, A | 1 |
| Fukushima, N | 1 |
| Coulson, GE; Keehn, JD; Klieb, J | 1 |
| Daniell, HB; Pierre, AJ; Webb, JG | 1 |
| Bianchetti, A; Gonalons, N; Guitard, J; Keane, PE; Langlois, X; Le Fur, G; Martin, P; Simiand, J; Soubrié, P | 1 |
| Chiba, S; Furukawa, Y; Saegusa, K; Takeda, M | 1 |
| Howell, RE; Lanken, PN | 1 |
| Alhaider, AA; Mustafa, AA | 2 |
| Chiba, S; Furukawa, Y; Karasawa, Y; Murakami, M; Narita, M; Ren, LM; Takei, M | 2 |
| Borsini, F; D'Aranno, V; Lecci, A; Mancinelli, A; Meli, A; Stasi, MA | 1 |
| Mück-Seler, D; Pericić, D | 1 |
| Higashi, Y; Murakami, T; Nishiura, A; Toyoda, T; Yata, N | 1 |
| Abel, EL; Bilitzke, P | 1 |
| Karagianis, JL; Nagpurkar, R | 1 |
| Akahane, K; Chiba, S; Karasawa, Y; Ren, LM | 1 |
| Beavis, AD | 1 |
| Enyeart, JJ; Hinkle, PM; Phillips, WJ | 1 |
| Albelda, SM; Fishman, AP; Hansen-Flaschen, JH; Haselton, FR; Howell, RE; Lanken, PN | 1 |
| Junien, JL; Pascaud, X; Roman, F; Vauché, D | 1 |
| Kellner, R | 1 |
| Henneberry, RC; Jahangeer, S; Lysko, PG | 1 |
| Anderson, W; Dickinson, KE; Hirschowitz, BI; Matsumoto, H; Pruitt, RE; Uemura, N | 1 |
| Butt, MM | 1 |
| Chakravarti, S; Kulkarni, SK; Parale, MP | 1 |
| Wood, M | 1 |
| Durand, P; Zachowski, A | 1 |
| Coudert, B; Dwyer, TM; Joshi, UM; Kodavanti, PR; Mehendale, HM | 1 |
| Hanano, M; Iga, T; Kurihara, A; Sawada, Y; Sugiyama, Y; Suzuki, H | 1 |
| Akahane, K; Chiba, S; Furukawa, Y; Haniuda, M; Ogiwara, Y; Takeda, M | 1 |
| Andrews, P; Harder, A; Thomas, H | 1 |
| Chiba, S; Furukawa, Y; Ogiwara, Y; Saegusa, K; Takeda, M | 1 |
| Henneberry, RC; Lysko, PG; Novelli, A | 1 |
| Ginsberg, HN | 1 |
| Rosenbaum, JF; Tesar, GE | 1 |
| Ledewyn, S; Morin, D; Tillement, JP; Zini, R | 1 |
| Debuch, H; Harder, A | 1 |
| Muskin, PR | 1 |
| Dybing, E | 1 |
| Bell, S; Jhamandas, K; Sutak, M | 1 |
| Kadzielawa, K; Widy-Tyszkiewicz, E | 1 |
| Dunleavy, DL; MacLean, AW; Oswald, I | 1 |
| Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S | 1 |
| Dhalla, NS | 1 |
| Garattini, S; Jori, A; Paglialunga, S | 1 |
| Matsuo, S | 1 |
| Kośmider, S; Smolarz, W | 1 |
| Ankier, SI | 1 |
| Bhargava, KP; Dhasmana, KM; Dixit, KS; Sinha, JN | 2 |
| Contreras, E; Quijada, L; Tamayo, L | 1 |
| Bottaccini, MR; Gleason, DM; Reilly, RJ | 1 |
| Bhargava, KP; Gupta, MB; Tangri, KK | 1 |
| König, J; Mlejnková, M; Rysánek, K; Spánková, H; Synek, P | 1 |
| Schott, CE; Sesso, AM; Snyder, RC | 1 |
| Gillis, CN; Iwasawa, Y | 1 |
| Boyarsky, S; Labay, P | 2 |
| Akers, TK; Hammond, RE | 1 |
| Côté, M; Elias, G | 1 |
| Cheng, HC; Long, JP | 1 |
| Aihara, H; Miyauchi, T; Ozawa, H; Sasajima, M; Sugawara, K | 1 |
| Baum, T; Eckfeld, DK; Rowles, G; Shropshire, AT; Varner, LL | 1 |
| Oates, JA; Shand, DG | 1 |
| Bartelheimer, HK; Bauditz, W | 2 |
| Sjöstrand, SE | 1 |
| Roth, S; Seeman, P | 1 |
| Kadzielawa, K; Widy, E | 1 |
| Brody, TM; McNeill, JH | 1 |
| Marshall, AS; Weinstock, M | 1 |
| Grewal, RS; Kaul, CL | 1 |
| McLean, JR; Potoczak, D | 1 |
| Applebaum, SM | 1 |
| Liebowitz, MR | 1 |
| Svensson, TH | 1 |
| Hietala, OA; Laitinen, PH; Laitinen, SI; Lapinjoki, SP; Pajunen, AE | 1 |
| Chiba, S; Kobayashi, M; Watanabe, H | 1 |
| Mehendale, HM; Morita, T | 1 |
| Stickler, GB; Van Winter, JT | 1 |
| Hara, C; Ueki, S; Watanabe, S | 1 |
| Edwards, MC; Evans, FJ; Taylor, SE; Williamson, EM | 1 |
| Hostetler, KY; Pappu, A | 1 |
| Chiba, S; Kobayashi, M; Shimotori, M | 1 |
| Greden, JF; Kronfol, Z; Zis, AP | 1 |
| Müller, WE; Stillbauer, AE | 1 |
| Mogilnicka, E | 1 |
| Pentel, P; Peterson, CD | 1 |
| Katerndahl, DA | 1 |
| Dock, DS; McNeil, GN; Shaw, PK | 1 |
| Barber, HE; Kitteringham, NR; Petrie, JC | 1 |
| Hostetler, KY; Matsuzawa, Y | 1 |
| Bencuya, R; Nelson, PJ; Rudnick, G; Zito, RA | 1 |
| Ahtee, L; Briley, M; Langer, SZ; Lebrec, D; Raisman, R | 1 |
| Kornhauser, DM; Shand, DG; Vestal, RE | 1 |
| Cosbey, SH; Craig, I; Gill, R | 1 |
| Ito, Y; Kato, H; Nagata, O; Terasaki, T; Tsuji, A; Yamazaki, M; Yoshioka, K | 1 |
| Nadai, T; Sakane, T; Taki, Y; Yamashita, S; Yoshida, M | 1 |
| Gillette, DW; Tannery, LP | 1 |
| Abel, EL | 1 |
| Amabeoku, G; Chandomba, R | 1 |
| Friedman, M | 1 |
| Abel, EL; Hannigan, JH | 1 |
| Kanakubo, Y; Kitada, M; Kiuchi, M; Ohmori, S; Rikihisa, T; Takeda, S | 1 |
| Hashimoto, S; Kasahara, K; Nagatani, T; Takao, K | 1 |
| Fujio, N; Funae, Y; Horie, T; Imaoka, S; Masubuchi, Y; Narimatsu, S; Suzuki, T; Takahashii, C | 1 |
| Breese, GR; Duncan, GE; Johnson, KB; Knapp, DJ | 1 |
| Fujii, A; Nakata, Y; Nishio, H | 1 |
| Duman, RS; Morinobu, S; Strausbaugh, H; Terwilliger, R | 1 |
| Amabeoku, GJ; Syce, JA | 1 |
| Obach, RS | 1 |
| Boukef, MF; Duché, JC; Jolliet-Riant, P; Simon, N; Tillement, JP | 1 |
| Lu, W; McCarley, TD; Shamsi, SA; Warner, IM | 1 |
| Jira, T; Karbaum, A | 1 |
| Chiba, S; Furukawa, Y; Hirose, M; Kurogouchi, F; Nakajima, K; Tsuboi, M; Zhao, D | 1 |
| Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I | 1 |
| Butterweck, V; Prinz, S; Schwaninger, M | 1 |
| Akahori, F; Fujita, S; Ishizuka, M; Kazusaka, A; Lee, JJ; Masuda, M | 1 |
| Hallifax, D; Houston, JB | 2 |
| Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y | 1 |
| Guillaume, P; Lacroix, P; Provost, D | 1 |
| Chen, SQ; Hu, HH; Jiang, HD; Kong, LM; Qian, MR; Xu, SY; Yu, LS; Zeng, S | 1 |
| Beeram, S; Bi, C; Hage, DS; Zheng, X | 1 |
| Bi, C; Clarke, W; Hage, DS; Isingizwe, Z; Matsuda, R; Zhang, C | 1 |
| Barbui, C; Bighelli, I; Breilmann, J; Castellazzi, M; Cipriani, A; Davies, SJ; Furukawa, TA; Girlanda, F; Guaiana, G; Koesters, M | 1 |
| Pardridge, WM | 1 |
9 review(s) available for imipramine and propranolol
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.
Topics: Animals; Computer Simulation; Drug Design; Humans; Isoquinolines; Neoplasms; Protein Kinase Inhibitors; Quinoxalines; Receptor, EphB2; Structure-Activity Relationship; Xanthine | 2016 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Some clinical implications of adrenergic receptors in the urinary tract.
Topics: Adrenergic Agonists; Adrenergic alpha-Antagonists; Autonomic Agents; Estrogens; Female; Humans; Imipramine; Male; Medroxyprogesterone; Phenoxybenzamine; Phentolamine; Progesterone; Propranolol; Prostate; Prostatitis; Receptors, Adrenergic; Thioridazine; Ureter; Urethra; Urinary Bladder; Urinary Incontinence, Stress; Urinary Tract; Urologic Diseases | 1975 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors | 1986 |
Pharmacologic agents in micturitional disorders.
Topics: Baclofen; Bethanechol Compounds; Dantrolene; Dicyclomine; Ephedrine; Flavoxate; Guanethidine; Humans; Imipramine; Mandelic Acids; Methyldopa; Neostigmine; Phenoxybenzamine; Phentolamine; Phenylephrine; Phenylpropanolamine; Propantheline; Propranolol; Quaternary Ammonium Compounds; Urinary Bladder; Urination Disorders | 1980 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Monoamine Oxidase Inhibitors; Personality Disorders; Phenelzine; Propranolol; Psychotropic Drugs; Schizophrenia | 1982 |
Effect of chronic treatment with tricyclic antidepressant drugs on identified brain noradrenergic and serotonergic neurons.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Clonidine; Drug Interactions; Imipramine; Iontophoresis; Lysergic Acid Diethylamide; Male; Neurons; Norepinephrine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Serotonin; Yohimbine | 1980 |
Benzodiazepines versus placebo for panic disorder in adults.
Topics: Adult; Aged; Agoraphobia; Benzodiazepines; Buspirone; Humans; Imipramine; Middle Aged; Numbers Needed To Treat; Panic Disorder; Paroxetine; Patient Dropouts; Placebos; Propranolol; Randomized Controlled Trials as Topic; Remission Induction; Young Adult | 2019 |
1 trial(s) available for imipramine and propranolol
| Article | Year |
|---|---|
Debrisoquine, guanethidine, propranolol and human sleep.
Topics: Adult; Amidines; Antihypertensive Agents; Blood Pressure; Cerebral Cortex; Dextroamphetamine; Electroencephalography; Electromyography; Electrooculography; Female; Guanethidine; Humans; Imipramine; Isoquinolines; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Placebos; Propranolol; Sleep; Sleep Stages; Sleep, REM; Time Factors | 1971 |
194 other study(ies) available for imipramine and propranolol
| Article | Year |
|---|---|
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Monocarboxylic Acid Transporters; Structure-Activity Relationship; Symporters | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT
Topics: Animals; Antidepressive Agents; Behavior, Animal; Computer-Aided Design; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Hydantoins; Male; Mice; Models, Molecular; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2018 |
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
Topics: Alkynes; Animals; Anti-Bacterial Agents; Half-Life; Methicillin-Resistant Staphylococcus aureus; Mice; Microsomes, Liver; Staphylococcal Infections; Thiazoles | 2018 |
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; Structure-Activity Relationship | 2019 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Molecular Structure; Staphylococcal Infections; Structure-Activity Relationship; Thiazoles | 2020 |
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Topics: Animals; Blood Proteins; Celecoxib; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Design; Female; Half-Life; Humans; Isoenzymes; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phosphodiesterase 5 Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2021 |
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
Topics: Binding Sites; Crystallography, X-Ray; Drug Stability; Humans; Kelch-Like ECH-Associated Protein 1; Ligands; Magnetic Resonance Spectroscopy; Microsomes; Molecular Dynamics Simulation; NF-E2-Related Factor 2; Protein Binding; Protein Interaction Maps; Small Molecule Libraries; Structure-Activity Relationship; Surface Plasmon Resonance | 2021 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent
Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Male; Molecular Docking Simulation; Molecular Structure; Protein Binding; Rats, Sprague-Dawley; Structure-Activity Relationship | 2021 |
Failure of neurotransmitter blockers to alter PGE2-induced LH release.
Topics: Animals; Castration; Cyclic AMP; Ditiocarb; Estradiol; Female; Hypothalamus; Imipramine; Injections, Intravenous; Luteinizing Hormone; Methyltyrosines; Neurotransmitter Agents; Phenoxybenzamine; Pituitary Gland; Propranolol; Prostaglandins E; Rats | 1976 |
Catalytic tritiation of drugs and analysis of the tritium distribution by 3H n.m.r. spectroscopy.
Topics: Amphetamine; Catalysis; Dextropropoxyphene; Imipramine; Isotope Labeling; Magnetic Resonance Spectroscopy; Phenobarbital; Phenytoin; Propranolol; Tritium | 1979 |
Some aspects of the psychopharmacological activity of maprotiline (Ludiomil): effects of single and repeated treatments.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Anthracenes; Behavior, Animal; Body Temperature; Clomipramine; Depression, Chemical; Escape Reaction; Haplorhini; Head; Imipramine; Maprotiline; Mice; Muscle Contraction; Phenobarbital; Propranolol; Rats; Reserpine; Shrews | 1978 |
Involvement of biogenic amines in drug-induced aggressive pecking in chicks.
Topics: Aggression; Animals; Animals, Newborn; Antidepressive Agents; Biogenic Amines; Chickens; Dextroamphetamine; Dopamine; Female; Fenclonine; Haloperidol; Humans; Imipramine; Iprindole; Levodopa; Male; Methysergide; Pargyline; Phentolamine; Propranolol; Serotonin | 1975 |
Role of brain monoamines in the anticonvulsant effect of imipramine in albino rats.
Topics: Animals; Anticonvulsants; Apomorphine; Catecholamines; Ditiocarb; Dopamine; Drug Interactions; Electroshock; Female; Fenclonine; Haloperidol; Hydroxydopamines; Imipramine; Male; Methyldopa; Methyltyrosines; Methysergide; Norepinephrine; Phenoxybenzamine; Propranolol; Rats; Reserpine; Seizures; Serotonin | 1976 |
Failure of neurotransmitter blockers to alter PGE2-induced LH release.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Cyclic AMP; Ditiocarb; Female; Hypothalamus; Imipramine; Luteinizing Hormone; Methyltyrosines; Phenoxybenzamine; Pituitary Gland, Anterior; Propranolol; Prostaglandins E; Rats; Thiocarbamates | 1977 |
Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Evaluation of function with pharmacodynamics.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bethanechol Compounds; Dogs; Enuresis; Ephedrine; Female; Humans; Imipramine; Male; Parasympatholytics; Phenoxybenzamine; Propranolol; Receptors, Adrenergic; Receptors, Cholinergic; Sensory Receptor Cells; Urethra; Urinary Bladder, Neurogenic; Urinary Incontinence | 1975 |
Uptake and efflux of 14C-paraquat by rat lung slices: the effect of imipramine and other drugs.
Topics: Animals; Biogenic Amines; Central Nervous System Agents; Diphenhydramine; Dose-Response Relationship, Drug; Imipramine; In Vitro Techniques; Lung; Male; Paraquat; Propranolol; Rats | 1979 |
Effects of ethanol and acetaldehyde on the isolated, blood-perfused canine atrium.
Topics: Acetaldehyde; Animals; Atropine; Dogs; Ethanol; Female; Heart; Heart Rate; Imipramine; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Propranolol; Tetrodotoxin | 1979 |
Imipramine affects autonomic control of sinoatrial rate in isolated right atrial preparations.
Topics: Acetylcholine; Animals; Atrial Function; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart; Heart Atria; Heart Rate; Imipramine; Norepinephrine; Propranolol | 1979 |
Antagonism by d,1-propranolol of imipramine effects in mice.
Topics: Albuterol; Animals; Apomorphine; Body Temperature; Dextroamphetamine; Drug Interactions; Imipramine; Male; Mice; Oxotremorine; Propranolol; Reserpine; Yohimbine | 1979 |
Effects of imipramine on spontaneous rate and chronotropic responses to transmural stimulation in isolated right atrial preparations.
Topics: Animals; Atropine; Electric Stimulation; Female; Guinea Pigs; Heart Rate; Imipramine; In Vitro Techniques; Male; Propranolol; Sinoatrial Node | 1978 |
[Metabolism, secretion and liberation of hormones and mediators in the lungs].
Topics: Acetylcholine; Animals; Biotransformation; Bradykinin; Cats; Dogs; Hormones; Humans; Imipramine; Lung; Lysergic Acid Diethylamide; Norepinephrine; Propranolol; Prostaglandins; Rabbits; Serotonin; Sulfonamides | 1977 |
Augmenting procedures during L-dopa therapy for Parkinsonism.
Topics: Antacids; Dextroamphetamine; Drug Synergism; Female; Humans; Imipramine; Levodopa; Male; Middle Aged; Parkinson Disease; Propranolol | 1975 |
Influence of some antidepressant drugs on the circulatory system. I. Imipramine.
Topics: Animals; Atropine; Blood Pressure; Dihydroergotamine; Electrocardiography; Female; Hemodynamics; Imipramine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Quaternary Ammonium Compounds; Rabbits; Respiration | 1975 |
[Role of brain biogenic amines in the central thermoregulatory mechanism of the rat (author's transl)].
Topics: Adaptation, Physiological; Animals; Biogenic Amines; Blood Glucose; Body Temperature Regulation; Cerebral Ventricles; Dopamine; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Haloperidol; Hydroxydopamines; Hypothermia; Imipramine; Isoproterenol; Levodopa; Male; Norepinephrine; Oxygen Consumption; Phenoxybenzamine; Phenylephrine; Propranolol; Rats; Rectum; Serotonin; Skin Temperature | 1975 |
Effects of haloperidol on schedule-induced polydipsia.
Topics: Administration, Oral; Angiotensin II; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Haloperidol; Imipramine; Male; Propranolol; Rats; Reinforcement Schedule; Renin | 1976 |
A positive inotropic effect of propranolol on the canine myocardium: a presynaptic effect.
Topics: Animals; Dogs; Female; Heart; Hexamethonium Compounds; Imipramine; Male; Myocardial Contraction; Norepinephrine; Propranolol; Reserpine; Stimulation, Chemical; Tyramine | 1976 |
Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Alprenolol; Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Clenbuterol; Humans; Imipramine; In Vitro Techniques; Male; Mice; Motor Activity; Propranolol; Receptors, Adrenergic, beta; Tetrahydronaphthalenes | 1992 |
Tyraminelike action of succinylcholine in the isolated, blood-perfused canine atrium.
Topics: Animals; Atrial Function; Blood; Dogs; Heart Atria; Heart Rate; Hexamethonium; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Myocardial Contraction; Perfusion; Propranolol; Succinylcholine; Tetrodotoxin; Tyramine | 1992 |
Pulmonary accumulation of propranolol in vivo: sites and physiochemical mechanism.
Topics: Animals; Bronchoalveolar Lavage Fluid; Imipramine; Injections, Intravenous; Lidocaine; Lung; Lymph; Male; Propranolol; Sheep | 1992 |
Enhancement of imipramine-induced rat brain beta-adrenoreceptor desensitization by subacute co-administration of trazodone, zimelidine, quipazine or 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Drinking Behavior; Female; Fenclonine; Imipramine; Isoproterenol; Ketanserin; Methysergide; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists; Trazodone; Zimeldine | 1991 |
Effects of tetrodotoxin and imipramine on the cardiac responses to nicotine in isolated, blood-perfused canine heart preparations.
Topics: Animals; Coronary Circulation; Dogs; Electrocardiography; Electrodes; Heart; Heart Atria; Heart Rate; Heart Ventricles; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Myocardial Contraction; Nicotine; Propranolol; Tetrodotoxin | 1991 |
Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.
Topics: Animals; Behavior, Animal; Brain; Desipramine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Stereoisomerism; Swimming | 1991 |
Do imipramine and dihydroergosine possess two components--one stimulating 5-HT1 and the other inhibiting 5-HT2 receptors?
Topics: Animals; Brain; Ergotamines; Imipramine; Male; Mice; Mice, Inbred CBA; Motor Activity; Piperidines; Propranolol; Radioligand Assay; Rats; Rats, Inbred Strains; Ritanserin; Serotonin Antagonists; Syndrome | 1990 |
Cardiac responses to VIP and VIP-ergic-cholinergic interaction in isolated dog heart preparations.
Topics: Animals; Dogs; Electric Stimulation; Electrocardiography; Heart; Heart Rate; Imipramine; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Parasympathetic Nervous System; Propranolol; Swine; Tetrodotoxin; Vasoactive Intestinal Peptide | 1990 |
Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats.
Topics: Animals; Desipramine; Hydrogen-Ion Concentration; Imipramine; Injections, Intravenous; Male; Models, Biological; Phosphatidylserines; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Paternal alcohol exposure: paradoxical effect in mice and rats.
Topics: Animals; Behavior, Animal; Corticosterone; Ethanol; Female; Imipramine; Male; Metergoline; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Propranolol; Rats; Sex Factors; Social Isolation; Species Specificity; Swimming; Yohimbine | 1990 |
A case of Tourette syndrome developing during haloperidol treatment.
Topics: Aggression; Child; Child Behavior Disorders; Dose-Response Relationship, Drug; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Male; Propranolol; Tourette Syndrome | 1990 |
Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Cross Circulation; Dogs; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Imipramine; Male; Myocardial Contraction; Parasympatholytics; Propranolol; Pyrrolidinones; Tyramine | 1990 |
On the inhibition of the mitochondrial inner membrane anion uniporter by cationic amphiphiles and other drugs.
Topics: Algorithms; Amiodarone; Amitriptyline; Animals; Anion Transport Proteins; Benzodiazepinones; Calcimycin; Carrier Proteins; Hydrogen-Ion Concentration; Imipramine; Intracellular Membranes; Mitochondria; Propranolol; Quinine | 1989 |
Acceleration of rat brain beta-adrenoceptor subsensitivity following the coadministration of histamine receptor antagonists with imipramine.
Topics: Animals; Brain; Chlorpheniramine; Cimetidine; Drinking Behavior; Drug Interactions; Female; Guinea Pigs; Heart; Histamine Antagonists; Imipramine; In Vitro Techniques; Isoproterenol; Propranolol; Ranitidine; Rats; Receptors, Adrenergic, beta | 1989 |
Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses.
Topics: Anesthetics, Local; Animals; Benzocaine; Chlordiazepoxide; Chlorpromazine; Dibucaine; Hydrogen-Ion Concentration; Imipramine; Lidocaine; Pituitary Gland; Procaine; Prolactin; Propranolol; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Tetracaine; Thyrotropin-Releasing Hormone; Trifluoperazine; Verapamil | 1989 |
Pulmonary extraction of propranolol in normal and oxygen-toxic sheep.
Topics: Animals; Imipramine; Lung; Male; Oxygen; Propranolol; Reference Values; Sheep; Tritium | 1989 |
Evidence for a non-opioid sigma binding site in the guinea-pig myenteric plexus.
Topics: Animals; Binding, Competitive; Cell Membrane; Chlorpromazine; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Haloperidol; Imipramine; Male; Myenteric Plexus; Phenazocine; Propranolol; Receptors, Opioid; Receptors, sigma | 1988 |
Functional somatic symptoms and hypochondriasis. A survey of empirical studies.
Topics: Anti-Anxiety Agents; Attitude to Health; Benzodiazepines; Conditioning, Psychological; Culture; Diagnosis, Differential; Electroconvulsive Therapy; Humans; Hypochondriasis; Imipramine; Models, Psychological; Pain; Personality Disorders; Personality Inventory; Phenelzine; Prognosis; Propranolol; Psychotherapy; Sensory Thresholds; Social Class; Somatoform Disorders | 1985 |
Transport of beta-adrenergic antagonists in the absence of beta-adrenergic receptors in rat pituitary tumor cells.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Biological Transport; Cell Line; Colforsin; Cyclic AMP; Dihydroalprenolol; Epinephrine; Hydrogen-Ion Concentration; Imipramine; Kinetics; Monensin; Norepinephrine; Nucleotides; Oligomycins; Ouabain; Pituitary Neoplasms; Propanolamines; Propranolol; Rats; Receptors, Adrenergic, beta; Reserpine; Serotonin; Temperature | 1986 |
Muscarinic cholinergic receptor subtype on frog esophageal peptic cells: binding and secretion studies.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Esophagus; Imipramine; Kinetics; N-Methylscopolamine; Oxotremorine; Pepsinogens; Pirenzepine; Propranolol; Radioligand Assay; Rana catesbeiana; Receptors, Muscarinic; Scopolamine Derivatives | 1988 |
Managing antidepressant-induced sweating.
Topics: Depressive Disorder; Female; Humans; Imipramine; Propranolol; Sweating | 1989 |
Evidence of beta-adrenergic involvement in forced swimming-induced behavioural despair of mice.
Topics: Animals; Atenolol; Behavior, Animal; Female; Imipramine; Immobilization; Isoproterenol; Male; Metoprolol; Mice; Physical Exertion; Propranolol; Receptors, Adrenergic, beta; Reserpine; Stress, Psychological; Swimming | 1987 |
Biphasic nature of the binding of cationic amphipaths with artificial and biological membranes.
Topics: Buffers; Cations; Chlorpromazine; Erythrocyte Membrane; Humans; Hydrogen-Ion Concentration; Imipramine; Lipid Bilayers; Liposomes; Phosphatidylcholines; Phospholipids; Propranolol; Temperature | 1988 |
Types of interaction of amphiphilic drugs with phospholipid vesicles.
Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazine; Diphenylhexatriene; Imipramine; Lipidoses; Lung Diseases; Membrane Lipids; Phospholipids; Promethazine; Propranolol; Surface-Active Agents; Trimipramine | 1988 |
Uptake of propranolol by microvessels isolated from bovine brain.
Topics: 2,4-Dinitrophenol; Adsorption; Animals; Brain; Capillaries; Cattle; Dinitrophenols; Glutamine; Hypothermia; Imipramine; In Vitro Techniques; Microcirculation; Ouabain; Potassium Cyanide; Propranolol; Quinidine | 1987 |
Pharmacological analysis of chrono- and inotropic responses to diazepam in the isolated, blood-perfused canine atrium.
Topics: Acetylcholine; Adenosine; Animals; Atropine; Diazepam; Dogs; Drug Interactions; Heart Rate; Imipramine; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Perfusion; Propranolol; Tyramine | 1987 |
Chlorpromazine, other amphiphilic cationic drugs and praziquantel: effects on carbohydrate metabolism of Schistosoma mansoni.
Topics: Amitriptyline; Animals; Carbohydrate Metabolism; Chlorpromazine; Fluoxetine; Glucose; Imipramine; Lactates; Praziquantel; Propranolol; Schistosoma mansoni | 1987 |
Pharmacologic basis of responses to midazolam in the isolated, cross-perfused, canine right atrium.
Topics: Animals; Atropine; Benzodiazepinones; Blood Donors; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Atria; Heart Rate; Imipramine; In Vitro Techniques; Midazolam; Myocardial Contraction; Propranolol; Sympathetic Nervous System; Tetrodotoxin | 1987 |
Uptake of imipramine in neurons cultured from rat cerebellum.
Topics: Animals; Cells, Cultured; Cerebellum; Dicyclohexylcarbodiimide; Hydrogen-Ion Concentration; Imipramine; Kinetics; Monensin; Neurons; Propranolol; Rats; Subcellular Fractions; Temperature | 1987 |
Propranolol in the treatment of restless legs syndrome induced by imipramine withdrawal.
Topics: Depressive Disorder; Female; Humans; Imipramine; Middle Aged; Propranolol; Restless Legs Syndrome; Substance Withdrawal Syndrome | 1986 |
Successful use of clonazepam in patients with treatment-resistant panic disorder.
Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; Desipramine; Fear; Female; Humans; Imipramine; Male; Middle Aged; Panic; Phenelzine; Propranolol; Psychiatric Status Rating Scales | 1986 |
Inhibition of binedaline binding to human alpha 1-acid glycoprotein and other serum proteins by chlorpromazine, imipramine, and propranolol.
Topics: Adult; Antidepressive Agents; Binding, Competitive; Blood Proteins; Chlorpromazine; Dialysis; Female; Humans; Imipramine; Indoles; Male; Orosomucoid; Propranolol; Protein Binding | 1986 |
Changes of transition temperatures of phosphatidylcholine and phosphatidylglycerol in presence of amphiphilic drugs.
Topics: Amitriptyline; Chlorpromazine; Imipramine; Models, Biological; Phosphatidylcholines; Phosphatidylglycerols; Propranolol; Structure-Activity Relationship; Thermodynamics | 1986 |
Panics, prolapse, and PVCs.
Topics: Adult; Anxiety Disorders; Arrhythmias, Cardiac; Diagnosis, Differential; Fear; Female; Humans; Imipramine; Lorazepam; Male; Middle Aged; Mitral Valve Prolapse; Panic; Propranolol | 1985 |
Effects of membrane stabilizers on glucuronidation and amino acid transport in cultures of rat hepatoma cells.
Topics: Alanine; Aminoisobutyric Acids; Animals; Antipsychotic Agents; Biological Transport; Carcinoma, Hepatocellular; Cell Membrane; Cells, Cultured; Depression, Chemical; Glucuronates; Imipramine; Liver Neoplasms; Promazine; Propranolol; Protein Binding; Rats; Thioridazine | 1973 |
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug Synergism; Humans; Imipramine; Mecamylamine; Morphine; Morphine Dependence; Naloxone; Neurotransmitter Agents; Physostigmine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Substance Withdrawal Syndrome; Synaptic Transmission; Tolazoline | 1973 |
The influence of various pharmacological agents on the desynchronization produced by DOPA in the cerveau isolé preparation.
Topics: Animals; Cats; Chlorpromazine; Decerebrate State; Dihydroxyphenylalanine; Disulfiram; Electroencephalography; Heart Rate; Hydrazines; Imipramine; Phenoxybenzamine; Phentolamine; Propranolol; Reserpine | 1970 |
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices.
Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine | 1971 |
Mechanisms of sympathomimetic effects of dichloroisoproterenol: comparison with tyramine, nicotine and norepinephrine.
Topics: Animals; Atropine; Cocaine; Diaphragm; Drug Antagonism; Ganglionic Blockers; Guanidines; Heart; Heart Atria; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Iproniazid; Isoproterenol; Morphine; Nicotine; Norepinephrine; Pentolinium Tartrate; Phenoxybenzamine; Propranolol; Rats; Sympatholytics; Tranylcypromine; Tyramine | 1967 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine | 1967 |
Comparative effects of imipramine and propranolol on the transmembrane potentials of the isolated rabbit atria.
Topics: Animals; Catecholamines; Ethanolamines; Female; Heart; Heart Atria; Imipramine; In Vitro Techniques; Membrane Potentials; Propranolol; Rabbits; Stimulation, Chemical | 1967 |
[The effect of imipramine on the cardiac glycoside-induced arrhythmias in animal experiments].
Topics: Animals; Arrhythmias, Cardiac; Citrates; Digoxin; Dogs; Electrocardiography; Female; Heart Conduction System; Histamine H1 Antagonists; Imipramine; Injections, Intravenous; Male; Propranolol; Sodium | 1968 |
A calorigenic effect of imipramine in the mouse?
Topics: Adrenergic beta-Antagonists; Anilides; Animals; Body Temperature Regulation; Dinitrophenols; Hypothermia, Induced; Imipramine; Isoproterenol; Male; Mice; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Pyrrolidines; Sulfonic Acids; Thyroxine | 1969 |
Role of catecholamines in fatal hyperpyrexia induced by imipramine in MAOI treated rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Chlorisondamine; Chlorpromazine; Drug Antagonism; Female; Fever; Hypothalamus; Imipramine; Male; Nialamide; Phenoxybenzamine; Propranolol; Rabbits; Reserpine | 1970 |
Supersensitivity to alpha and beta effects of adrenaline induced by cocaine.
Topics: Animals; Cocaine; Dibenzylchlorethamine; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; Imipramine; In Vitro Techniques; Male; Muscle Contraction; Propranolol; Rats; Receptors, Adrenergic; Stomach; Tolazoline; Vas Deferens | 1974 |
Active and passive incontinence: differential diagnosis.
Topics: Adolescent; Adult; Aged; Atropine; Child; Cystoscopy; Diagnosis, Differential; Female; Humans; Hydroxyzine; Imipramine; Male; Methods; Middle Aged; Neurologic Examination; Pressure; Propranolol; Ureterocele; Urethra; Urinary Catheterization; Urinary Incontinence; Urinary Incontinence, Stress | 1974 |
Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.
Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Cordotomy; Dose-Response Relationship, Drug; Female; Hydrazines; Imipramine; Indomethacin; Lysergic Acid Diethylamide; Monoamine Oxidase Inhibitors; Oxyphenbutazone; Phenoxybenzamine; Phentolamine; Pregnancy; Propranolol; Rats; Stomach Ulcer | 1973 |
Relationship between substances strengthening of the thrombocyte cell membrane on the aggregation of thrombocytes and on the uptake and release of serotonin.
Topics: Adenosine Diphosphate; Amitriptyline; Benzothiepins; Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Colorimetry; Desipramine; Epinephrine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phentolamine; Piperazines; Platelet Adhesiveness; Propranolol; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Tranquilizing Agents | 1972 |
Propranolol in imipramine poisoning.
Topics: Electric Countershock; Female; Gastric Lavage; Humans; Imipramine; Poisoning; Propranolol; Respiration, Artificial; Ventricular Fibrillation | 1973 |
Pharmacological analysis of norepinephrine and 5-hydroxytryptamine removal from the pulmonary circulation: differentiation of uptake sites for each amine.
Topics: Aminophylline; Animals; Binding Sites; Binding, Competitive; Cocaine; Hydroxydopamines; Imipramine; Lung; Norepinephrine; Normetanephrine; Pargyline; Perfusion; Phenoxybenzamine; Phentolamine; Propranolol; Rabbits; Serotonin; Vasoconstrictor Agents | 1974 |
Urinary bladder contractility: action of imipramine.
Topics: Acetylcholine; Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Humans; Imipramine; In Vitro Techniques; Isoproterenol; Methods; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phenoxybenzamine; Propranolol; Rabbits; Receptors, Adrenergic; Receptors, Cholinergic; Urinary Bladder | 1974 |
Effect of adrenergic drugs on pulmonary responses to high-pressure oxygen.
Topics: Animals; Atmospheric Pressure; Catecholamines; Cocaine; Drug Combinations; Hemodynamics; Imipramine; Lung; Male; Oxygen; Phentolamine; Propranolol; Pulmonary Edema; Rats; Reserpine; Tyramine | 1974 |
[Propranolol in cardiac arrhythmia due to imipramine poisoning (tofranil) in children].
Topics: Cyanosis; Electrocardiography; Female; Gastric Lavage; Humans; Imipramine; Infant; Injections, Intravenous; Propranolol; Tachycardia | 1974 |
Dopaminergic nature of apomorphine-induced pecking in pigeons.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Chlorpromazine; Columbidae; Dihydroxyphenylalanine; Dioxoles; Dopamine; Haloperidol; Imipramine; Methyltyrosines; Nicotine; Oxotremorine; Phentolamine; Physostigmine; Pilocarpine; Propranolol; Receptors, Drug; Reserpine; Serotonin; Time Factors | 1974 |
[Pharmacological studies of lithium salts. 3. General pharmacological action of LiCl on the cardiovascular system and smooth muscles].
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Cardiovascular System; Cats; Chlorpromazine; Diphenhydramine; Dogs; Electrocardiography; Female; Guinea Pigs; Heart; Hexamethonium Compounds; Histamine; Imipramine; In Vitro Techniques; Intestine, Small; Lithium; Mice; Muscle, Smooth; Nictitating Membrane; Oxytocin; Phentolamine; Propranolol; Rats; Reserpine; Respiration; Serotonin; Stomach; Uterus | 1974 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Benzazepines; Bretylium Compounds; Chlorpheniramine; Diazepam; Disease Models, Animal; Dogs; Drug Antagonism; Guinea Pigs; Imipramine; Ketones; Lidocaine; Male; Meperidine; Mephentermine; Ouabain; Phentolamine; Phenytoin; Procainamide; Promazine; Promethazine; Propranolol; Quinidine | 1971 |
Action of imipramine on the detrusor muscle.
Topics: Acetylcholine; Animals; Cats; Dogs; Imipramine; Isoproterenol; Methods; Muscle Contraction; Muscles; Norepinephrine; Phenoxybenzamine; Propranolol; Rabbits; Reserpine; Sympathetic Nervous System; Urinary Bladder | 1971 |
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine | 1971 |
[Hemodialysis treatment of a 3 1-4-year-old child with imipramine poisoning].
Topics: Arrhythmias, Cardiac; Charcoal; Child, Preschool; Chloral Hydrate; Electrocardiography; Electroencephalography; Gastric Lavage; Humans; Hypotension; Imipramine; Magnesium Sulfate; Male; Norepinephrine; Oxygen; Paraldehyde; Procainamide; Propranolol; Renal Dialysis; Respiratory Insufficiency; Seizures; Ventilators, Mechanical | 1970 |
Pharmacological properties of dehydroascorbic acid and ascorbic acid. Effects on the central and peripheral nervous systems in experimental animals.
Topics: Acetylcholine; Adrenal Glands; Adrenalectomy; Animals; Ascorbic Acid; Blood Pressure; Brain; Bretylium Compounds; Carbon Isotopes; Cats; Central Nervous System; Chromatography; Cocaine; Cordotomy; Dopamine; Epinephrine; Ergotamine; Female; Guanethidine; Hexamethonium Compounds; Imipramine; Male; Mice; Motor Activity; Myocardium; Neuromuscular Junction; Nictitating Membrane; Norepinephrine; Peripheral Nerves; Phenoxybenzamine; Propranolol; Rabbits; Reserpine; Salivation; Tetraethylammonium Compounds | 1970 |
All lipid-soluble anaesthetics protect red cells.
Topics: Alcohols; Anesthetics; Anesthetics, Local; Barbiturates; Detergents; Erythrocytes; Fatty Acids; Hemolysis; Humans; Imipramine; In Vitro Techniques; Methods; Parasympathomimetics; Promethazine; Propranolol; Solubility; Steroids; Sympathomimetics; Tranquilizing Agents | 1971 |
Antagonism of imipramine induced fatal hyperpyrexia in MAO inhibitor treated rabbits.
Topics: Amino Alcohols; Animals; Body Temperature; Drug Antagonism; Female; Fever; Imipramine; Male; Monoamine Oxidase Inhibitors; Phenethylamines; Phenoxybenzamine; Propranolol; Rabbits; Sympatholytics; Time Factors | 1969 |
The influence of imipramine on the central effects of dihydroxyphenylalanine.
Topics: Animals; Blood Pressure; Brain; Cats; Chlorpromazine; Dihydroxyphenylalanine; Disulfiram; Electrodes; Electroencephalography; Gallamine Triethiodide; Heart Rate; Imipramine; Phenoxybenzamine; Phentolamine; Propranolol; Pupil; Rabbits; Reserpine | 1970 |
[Treatment of imipramine poisoning at childhood].
Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypotension; Imipramine; Magnesium Sulfate; Male; Norepinephrine; Oxygen Inhalation Therapy; Paraldehyde; Procaine; Propranolol; Renal Dialysis; Respiration, Artificial; Respiratory Insufficiency; Seizures | 1970 |
The effect of various drug pretreatments on amine-induced phosphorylase activation and amine uptake.
Topics: Amitriptyline; Animals; Carbon Isotopes; Depression, Chemical; Desipramine; Diphenhydramine; Drug Synergism; Female; Glucosyltransferases; Heart; Imipramine; Isoproterenol; Methylphenidate; Myocardium; Norepinephrine; Promethazine; Propranolol; Rats; Stimulation, Chemical; Tranylcypromine; Triprolidine; Tritium; Tyramine | 1968 |
The influence of the sympathetic nervous system on the action of drugs on the lens.
Topics: Animals; Blepharoptosis; Body Temperature; Cataract; Chlorpromazine; Female; Guanethidine; Imipramine; Methadone; Mice; Phenoxybenzamine; Phentolamine; Propranolol; Reserpine; Sympathectomy; Sympathetic Nervous System | 1969 |
Adrenaline reversal by CIBA 1002-Go.
Topics: Acetylcholine; Animals; Blood Pressure; Cats; Cocaine; Depression, Chemical; Dogs; Drug Synergism; Epinephrine; Female; Heart Rate; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Piperidines; Propranolol; Pyrazoles; Rabbits; Rats; Receptors, Drug; Stimulation, Chemical; Uterus | 1969 |
The effects of sodium and potassium on norepinephrine uptake by rabbit platelets and the inhibition of this process by drugs.
Topics: Animals; Blood Platelets; Carbon Isotopes; Chlorpromazine; Female; Hydrogen-Ion Concentration; Imipramine; Norepinephrine; Ouabain; Phenoxybenzamine; Potassium; Propranolol; Rabbits; Sodium; Stimulation, Chemical; Tryptamines | 1969 |
The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine. Dependence of ornithine decarboxylase induction on beta-adrenoceptors.
Topics: Adenosylmethionine Decarboxylase; Animals; Brain; Carboxy-Lyases; Chlorpromazine; Enzyme Induction; Imipramine; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phentolamine; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1983 |
Chronotropic and inotropic effects of captopril on the dog heart.
Topics: Animals; Captopril; Catecholamines; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imipramine; Myocardial Contraction; Proline; Propranolol; Stimulation, Chemical; Tyramine | 1983 |
Drug-specificity in the perturbation of pulmonary disposition of serotonin in rabbit in vivo.
Topics: Animals; Chlorpromazine; Clomipramine; Imipramine; Lung; Male; Propranolol; Rabbits; Radioisotope Dilution Technique; Serotonin | 1983 |
Panic attack syndrome.
Topics: Alprazolam; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Child; Fear; Humans; Hyperventilation; Imipramine; Male; Monoamine Oxidase Inhibitors; Panic; Phenelzine; Phobic Disorders; Propranolol; Syndrome | 1984 |
Anti-muricide mechanisms of chlorpromazine and imipramine in OB rats: adrenoceptors and hypothalamic functions.
Topics: Aggression; Animals; Catalepsy; Chlorpromazine; Electroencephalography; Humans; Hypothalamus; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic | 1984 |
New phorbol and deoxyphorbol esters: isolation and relative potencies in inducing platelet aggregation and erythema of skin.
Topics: Animals; Chemical Phenomena; Chemistry; Erythema; Female; Humans; Imipramine; Male; Mice; Phorbol Esters; Phorbols; Plants; Platelet Aggregation; Promethazine; Propranolol; Rabbits; Trifluoperazine | 1983 |
Effect of cationic amphiphilic drugs on the hydrolysis of acidic and neutral phospholipids by liver lysosomal phospholipase A.
Topics: Animals; Chlorpromazine; Chromatography, Agarose; Hydrolysis; Imipramine; Liver; Lysosomes; Male; Phospholipases; Phospholipases A; Phospholipids; Propranolol; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
Direct effects of catecholamines and tyramine on sinoatrial conduction in isolated and blood-perfused dog atria.
Topics: Animals; Atrioventricular Node; Catecholamines; Coronary Circulation; Dogs; Dopamine; Dose-Response Relationship, Drug; Epinephrine; Heart Atria; Heart Conduction System; Imipramine; In Vitro Techniques; Isoproterenol; Muscle Contraction; Norepinephrine; Propranolol; Time Factors; Tyramine | 1984 |
Imipramine-induced tremor: effects of a beta-adrenergic blocking agent.
Topics: Depressive Disorder; Humans; Imipramine; Male; Middle Aged; Propranolol; Tremor | 1983 |
Characterization of a common binding site for basic drugs on human alpha 1-acid glycoprotein (orosomucoid).
Topics: Binding Sites; Chlorpromazine; Drug Interactions; Humans; Imipramine; Ligands; Orosomucoid; Propranolol; Regression Analysis | 1983 |
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.
Topics: Albuterol; Animals; Clonidine; Desipramine; Drug Interactions; Exploratory Behavior; Fluoxetine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Yohimbine | 1982 |
Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bradycardia; Electrocardiography; Heart Arrest; Humans; Imipramine; Male; Parasympatholytics; Physostigmine; Propranolol | 1980 |
Panic.
Topics: Adult; Anxiety Disorders; Cardiovascular Diseases; Endocrine System Diseases; Fear; Female; Humans; Imipramine; Mental Disorders; Panic; Phenelzine; Propranolol; Sex Factors; Sleep Wake Disorders; Substance Withdrawal Syndrome | 1982 |
Substitution of atenolol for propranolol in a case of propranolol-related depression.
Topics: Angina Pectoris; Atenolol; Depressive Disorder; Female; Humans; Hypertension; Imipramine; Middle Aged; Myocardial Infarction; Propanolamines; Propranolol | 1982 |
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.
Topics: Animals; Biotransformation; Chlorpromazine; Imipramine; Kinetics; Liver; Male; Metyrapone; Proadifen; Propranolol; Rats; Rats, Inbred Strains; Spinal Cord | 1982 |
Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C.
Topics: Amantadine; Aniline Compounds; Animals; Chlorphentermine; Chlorpromazine; Heptanes; Imipramine; Lipidoses; Liver; Lysosomes; Male; Pharmacology; Phospholipases; Phospholipases A; Propranolol; Rats; Tripelennamine; Type C Phospholipases | 1981 |
Inhibition of platelet serotonin transport by propranolol.
Topics: Animals; Binding Sites; Biological Transport, Active; Blood Platelets; Cell Membrane; Cytoplasmic Granules; Humans; Imipramine; In Vitro Techniques; Propranolol; Serotonin; Swine | 1981 |
Reduced uptake of serotonin but unchanged 3H-imipramine binding in the platelets from cirrhotic patients.
Topics: Blood Platelets; Humans; Imipramine; In Vitro Techniques; Kinetics; Liver Cirrhosis, Alcoholic; Propranolol; Serotonin | 1981 |
Uptake of propranolol by the lung and its displacement by other drugs: involvement of the alveolar macrophage.
Topics: Animals; Chlorpromazine; Dogs; Drug Interactions; Hemodynamics; Imipramine; Lung; Macrophages; Perfusion; Propranolol; Pulmonary Alveoli; Rabbits; Tissue Distribution | 1980 |
A pharmacologic analysis of chronotropic and inotropic responses to direct electrical stimulation of the isolated, blood-perfused canine atrium.
Topics: Animals; Atrial Function; Atropine; Dogs; Electric Stimulation; Heart; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Myocardial Contraction; Physostigmine; Propranolol; Sinoatrial Node; Tetrodotoxin | 1980 |
Novel solid-phase extraction strategy for the isolation of basic drugs from whole blood. Preliminary study using commercially available extraction cartridges.
Topics: Adsorption; Animals; Blood Chemical Analysis; Cation Exchange Resins; Chromatography; Gas Chromatography-Mass Spectrometry; Imipramine; Nortriptyline; Pharmaceutical Preparations; Propranolol; Quinine; Sheep; Solubility | 1995 |
Carrier-mediated transport of H1-antagonist at the blood-brain barrier: a common transport system of H1-antagonists and lipophilic basic drugs.
Topics: Animals; Blood-Brain Barrier; Carrier Proteins; Cattle; Cells, Cultured; Endothelium, Vascular; Histamine H1 Antagonists; Imipramine; Lidocaine; Propranolol; Pyrilamine; Solubility | 1994 |
Kinetic analysis of the drug permeation process across the intestinal epithelium.
Topics: Animals; Antipyrine; Imipramine; Intestinal Mucosa; Male; Mannitol; Permeability; Pharmacokinetics; Propranolol; Rats; Rats, Wistar; Water | 1994 |
Beta blocker inhibits tricyclic metabolism.
Topics: Adrenergic beta-Antagonists; Aggression; Anger; Antidepressive Agents, Tricyclic; Child; Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Imipramine; Male; Metabolic Clearance Rate; Propranolol; Stress Disorders, Post-Traumatic | 1994 |
Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats.
Topics: Animals; Arousal; Brain; Citalopram; Clonidine; Dose-Response Relationship, Drug; Imipramine; Male; Norepinephrine; Nortriptyline; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, GABA; Reserpine; Serotonin; Yohimbine | 1994 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine | 1994 |
Iatrogenic alopecia.
Topics: Aged; Alopecia; Female; Humans; Iatrogenic Disease; Imipramine; Propranolol | 1994 |
The immobility response in the forced swim test: paradoxical effect of imipramine.
Topics: Alprazolam; Animals; Behavior, Animal; Imipramine; Male; Motor Activity; Propranolol; Rats; Rats, Inbred F344 | 1994 |
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin | 1993 |
Role of 5-HT1A receptors in the forced swimming wheel test in reserpine-treated mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Interactions; Imipramine; Male; Mice; Mice, Inbred ICR; Motor Activity; Propranolol; Receptors, Serotonin; Reserpine; Swimming | 1993 |
Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ferricyanides; Imipramine; Immunoblotting; Isoenzymes; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Propranolol; Rats; Rats, Wistar; Testosterone | 1995 |
Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.
Topics: Animals; Antidepressive Agents; Brain; Deoxyglucose; Imipramine; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stress, Physiological; Swimming | 1996 |
Re-examination for pharmacological properties of serotonin-induced tachycardia in isolated guinea-pig atrium.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Excitatory Amino Acid Antagonists; Guinea Pigs; Heart; Heart Atria; Heart Rate; Imipramine; In Vitro Techniques; Male; Memantine; Myocardial Contraction; Propranolol; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists | 1996 |
Regulation of c-Fos and NGF1-A by antidepressant treatments.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Blotting, Western; Dizocilpine Maleate; DNA-Binding Proteins; Dopamine Antagonists; Early Growth Response Protein 1; Electroshock; Excitatory Amino Acid Antagonists; Frontal Lobe; Genes, fos; Genes, Immediate-Early; Haloperidol; Imipramine; Immediate-Early Proteins; Ketanserin; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Transcription Factors; Transcription, Genetic; Tranylcypromine | 1997 |
Propranolol-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Disulfiram; Droxidopa; Drug Synergism; Female; Imipramine; Isoproterenol; Male; Mice; Norepinephrine; Pargyline; Propranolol; Reserpine; Seizures | 1997 |
Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
Topics: Animals; Blood Proteins; Cell Line; Dogs; Enzyme Activation; Haplorhini; Humans; Imipramine; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Propranolol; Protein Binding; Rats; Spodoptera; Warfarin | 1997 |
The genetic variant A of human alpha 1-acid glycoprotein limits the blood to brain transfer of drugs it binds.
Topics: Animals; Blood-Brain Barrier; Chlorpromazine; Disopyramide; Genetic Variation; Humans; Imipramine; Male; Methadone; Mifepristone; Orosomucoid; Pharmacokinetics; Propranolol; Protein Binding; Rats; Rats, Wistar | 1998 |
On-line capillary electrophoresis-electrospray ionization mass spectrometry using a polymerized anionic surfactant.
Topics: Adrenergic beta-Antagonists; Alprenolol; Amitriptyline; Anions; Antidepressive Agents, Tricyclic; Cations; Doxepin; Electrophoresis, Capillary; Imipramine; Mass Spectrometry; Polymers; Propranolol; Sulfates; Surface-Active Agents; Undecylenic Acids | 1998 |
Nonaqueous capillary electrophoresis: application possibilities and suitability of various solvents for the separation of basic analytes.
Topics: Carteolol; Electrophoresis, Capillary; Imipramine; Propranolol; Solvents | 1999 |
A Na+/Ca2+ exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations.
Topics: Animals; Atropine; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hexamethonium; Imipramine; Isoproterenol; Myocardial Contraction; Ouabain; Perfusion; Propranolol; Sodium-Calcium Exchanger; Tetrodotoxin; Thiourea; Verapamil | 2000 |
Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester.
Topics: Animals; Brain Neoplasms; Cell Compartmentation; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glioma; Imipramine; Indoles; Isoenzymes; Maleimides; Neoplasm Proteins; Phospholipase D; Propranolol; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice.
Topics: Adrenal Glands; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Diazepam; Emotions; GABA Modulators; Hyperthermia, Induced; Hypothalamus; Imipramine; Interleukin-6; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Pituitary Gland; Propranolol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen; Stress, Psychological | 2003 |
CYP2D-related metabolism in animals of the Canoidea superfamily - species differences.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Canidae; Cytochrome P-450 Enzyme System; Dogs; Foxes; Hydroxylation; Imipramine; Isoenzymes; Liver; Male; Microsomes, Liver; Mink; Propanolamines; Propranolol; Rats; Reactive Nitrogen Species; Stereoisomerism; Ursidae | 2006 |
Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
Topics: Amines; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Hepatocytes; Imipramine; In Vitro Techniques; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley | 2006 |
Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.
Topics: Algorithms; Amines; Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dextromethorphan; Fluoxetine; Fluvoxamine; Hepatocytes; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Imipramine; In Vitro Techniques; Kinetics; Male; Models, Biological; Propranolol; Quinine; Rats; Rats, Sprague-Dawley | 2007 |
Pharmacophore modeling for hERG channel facilitation.
Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis | 2012 |
Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
Topics: Animal Husbandry; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Protocols; Digoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Imipramine; Male; Propranolol | 2009 |
Comparison of catalytical activity and stereoselectivity between the recombinant human cytochrome P450 2D6.1 and 2D6.10.
Topics: Adrenergic beta-Antagonists; Algorithms; Alleles; Antidepressive Agents, Tricyclic; Baculoviridae; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Data Interpretation, Statistical; Humans; Hydroxylation; Imipramine; Isoenzymes; Kinetics; NADP; Propranolol; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Substrate Specificity | 2012 |
Chromatographic studies of drug interactions with alpha
Topics: Chlorpromazine; Chromatography, Affinity; Humans; Imipramine; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Verapamil | 2017 |
Studies of drug interactions with alpha
Topics: Antibodies; Chlorpromazine; Chromatography, Affinity; Disopyramide; Drug Interactions; Humans; Imipramine; Orosomucoid; Pharmaceutical Preparations; Propranolol; Protein Binding; Warfarin | 2017 |
Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs.
Topics: Albumins; Blood Proteins; Brain; Imipramine; Pharmaceutical Preparations; Propranolol; Protein Binding | 2023 |