imipramine has been researched along with proadifen in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (97.30) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Grudin, R; Moldèus, P; Orrenius, S; Vadi, H | 1 |
| Kappus, H; Remmer, H | 1 |
| Renyi, AL; Ross, SB | 1 |
| Stöcklin, K; Waldmeier, PC | 1 |
| Gawell, L; Hall, H; Ross, SB | 1 |
| Brunswick, DJ; Goodman, C; Kreider, MS; Wolfe, J | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Illing, HP; Kunke, S; Netter, KJ | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Lind, N; Parkes, MW | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 2 |
| Bernardi, D; Jori, A | 1 |
| Colson, SH; Tolson, WW; Umberger, EJ | 1 |
| Bickel, MH | 1 |
| Clark, B; Thompson, JW; Widdrington, G | 1 |
| Borg, KO; Grundin, R; Moldéus, P; Orrenius, S; Skånberg, I; von Bahr, C | 1 |
| Doi, T; Kojima, S; Tsujimoto, A | 1 |
| Castro, JA; Díaz Gómez, MI | 2 |
| Bellward, GD; Black, NB; Dayton, PG; O'Brien, L; Perel, JM | 1 |
| Michaelis, W; Stille, G | 1 |
| Osswald, W; Viana, AP | 1 |
| Nakazawa, K | 1 |
| Bickel, MH; Minder, R | 1 |
| Calhoun, FJ; Schrogie, JJ; Tolson, WW | 1 |
| Castro, JA; Cignoli, EV | 1 |
| Gillette, J; Hammer, W; Schumacher, H; Sjöqvist, F | 1 |
| Bickel, MH; Weder, HJ | 1 |
| Spencer, PS | 1 |
| Lippmann, W; Wishnick, M | 1 |
| Christ, W; Hecker, W; Junge, H; Stille, G | 1 |
| Barber, HE; Kitteringham, NR; Petrie, JC | 1 |
| Daniel, W; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 1 |
| Mehendale, HM; Ohmiya, Y | 1 |
| Ishikawa, K; Sato, Y; Shibanoki, S; Sugahara, M | 1 |
37 other study(ies) available for imipramine and proadifen
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Drug metabolism in isolated rat liver cells.
Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium | 1975 |
Irreversible protein binding of [14-C]imipramine with rat and human liver microsomes.
Topics: Animals; Carbon Monoxide; Cattle; Cytochrome P-450 Enzyme Inhibitors; Epoxide Hydrolases; Humans; Imipramine; In Vitro Techniques; Male; Microsomes, Liver; NADP; Proadifen; Protein Binding; Rats; Rifampin; Serum Albumin, Bovine; Sulfhydryl Compounds; Time Factors | 1975 |
Tricyclic antidepressant agents. II. Effect of oral administration on the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices of the midbrain-hypothalamus region of the rat.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biotransformation; Desipramine; Hypothalamus; Imipramine; Male; Mesencephalon; Norepinephrine; Proadifen; Rats; Serotonin; Time Factors | 1975 |
The reversible MAO inhibitor, brofaromine, inhibits serotonin uptake in vivo.
Topics: Animals; Brain; Imipramine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Piperidines; Proadifen; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1989 |
Stereoselective high-affinity binding of 3H-alaproclate to membranes from rat cerebral cortex.
Topics: Alanine; Animals; Antidepressive Agents; Binding, Competitive; Cell Membrane; Cerebral Cortex; Imipramine; In Vitro Techniques; Kinetics; Male; Proadifen; Rats; Rats, Inbred Strains; Stereoisomerism; Subcellular Fractions | 1987 |
Labeling in vivo of serotonin uptake sites in rat brain after administration of [3H]cyanoimipramine.
Topics: 5,7-Dihydroxytryptamine; Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Hypothalamus; Imipramine; Male; Proadifen; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Time Factors | 1987 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
On the spectral intermediate at 440 nm formed during mixed function substrate oxidation.
Topics: Acetanilides; Aniline Compounds; Animals; Barbiturates; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pentobarbital; Proadifen; Protein Binding; Rats; Spectrophotometry, Ultraviolet | 1974 |
N-demethylation and N-oxidation of imipramine by rat and pig liver microsomes.
Topics: Animals; Biotransformation; Dealkylation; Edetic Acid; Imipramine; In Vitro Techniques; Magnesium; Male; Microsomes, Liver; Niacinamide; Phenobarbital; Proadifen; Rats; Stimulation, Chemical; Swine | 1971 |
Effects of inhibition and induction of the liver microsomal enzyme system on the narcotic activity of ethanol in mice.
Topics: Amitriptyline; Animals; Chlorpromazine; Drug Synergism; Enzyme Induction; Ethanol; Female; Imipramine; Liver; Mice; Microsomes; Pentobarbital; Proadifen; Sleep | 1967 |
Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH.
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; Kinetics; Liver; Male; Microsomes; Morphine; NADP; Niacinamide; Oxidation-Reduction; Pigments, Biological; Proadifen; Rats; Sex Factors; Spectrophotometry; Transferases | 1968 |
Brain desipramine level in relation to the anti-reserpine acitivity of imipramine.
Topics: Animals; Body Temperature; Cats; Desipramine; Female; Imipramine; Proadifen; Reserpine; Tetrabenazine | 1968 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.
Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase | 1969 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.
Topics: Amitriptyline; Animals; Carbon Isotopes; Carbon Monoxide; Chlorpromazine; Cyclic N-Oxides; Cytochromes; Dealkylation; Desipramine; Horses; Imipramine; Kinetics; Liver; Male; NADP; Organ Specificity; Oxidation-Reduction; Proadifen; Rats; Species Specificity; Subcellular Fractions; Swine; Tetrazolium Salts | 1972 |
Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man.
Topics: Amphetamine; Animals; Chlorpromazine; Desipramine; Drug Interactions; Histamine; Hydrazines; Hydrocortisone; Imipramine; Iproniazid; Male; Meperidine; Methylation; Microsomes, Liver; Monoamine Oxidase Inhibitors; Nialamide; Opipramol; Phenothiazines; Phenylhydrazines; Prednisolone; Proadifen; Promazine; Rats; Transferases | 1972 |
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.
Topics: Administration, Oral; Alprenolol; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Imipramine; Injections, Intravenous; Liver; Male; Methods; Metyrapone; Microsomes, Liver; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry; Time Factors; Tritium | 1974 |
Potent inhibitory action of pilocarpine on hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Depression, Chemical; Ethylamines; Glucosephosphate Dehydrogenase; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Nicotine; Phenols; Pilocarpine; Proadifen; Rabbits; Spectrophotometry; Tritium | 1972 |
Effect of inhibitors of drug metabolism on mitochondrial swelling and on carbon tetrachloride-induced lysosomal damage.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride Poisoning; Drug Antagonism; Ethylamines; Imipramine; In Vitro Techniques; Liver; Lysosomes; Malonates; Mitochondria, Liver; Mitochondrial Swelling; Permeability; Phenethylamines; Proadifen; Proteins; Rats; Ribonucleases; Statistics as Topic; Time Factors | 1973 |
Imipramine and chlorpromazine in hepatic microsomal systems.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Microsomes, Liver; Phenobarbital; Proadifen; Proteins; Spectrophotometry, Ultraviolet | 1974 |
Studies on the interaction between inhibitors of drug metabolism and horse plasma cholinesterase.
Topics: Acetylcholinesterase; Animals; Binding Sites; Biphenyl Compounds; Cattle; Chemical Phenomena; Chemistry; Chemistry, Physical; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Ethylamines; Horses; Hydrogen-Ion Concentration; Imipramine; Kinetics; Organophosphorus Compounds; Proadifen; Vinyl Compounds | 1971 |
Imipramine demethylation and norepinephrine storage in brain.
Topics: Animals; Brain Chemistry; Cerebral Ventricles; Chromatography, Thin Layer; Female; Imipramine; Injections; Norepinephrine; Normetanephrine; Proadifen; Rats; Tritium | 1970 |
Antiarrhythmic effects of proadifen hydrochloride (SKF 525-A).
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Barbiturates; Barium; Blood Pressure; Bradycardia; Chlorides; Conjunctiva; Cornea; Depression, Chemical; Digitoxin; Dogs; Electrocardiography; Epinephrine; Heart Rate; Hydrochloric Acid; Hypotension; Imipramine; Irritants; Ouabain; Petroleum; Proadifen; Rabbits; Reflex | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. I. Experiments in vivo and with isolated perfused livers.
Topics: Alcohols; Animals; Benzyl Compounds; Bile; Bile Acids and Salts; Biliary Fistula; Chromatography, Thin Layer; Desipramine; Glucuronates; Imines; Imipramine; Injections, Intravenous; Intestine, Small; Kinetics; Laparotomy; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Time Factors | 1970 |
Effects of various drugs on the uterotropic response to mestranol and norethynodrel in the rat.
Topics: Aminosalicylic Acids; Animals; Chlorpromazine; Drug Synergism; Female; Imipramine; Mestranol; Norethynodrel; Organ Size; Phenobarbital; Phenylbutazone; Phenytoin; Proadifen; Rats; Scopolamine; Tolbutamide; Uterus | 1971 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Depression, Chemical; Drug Antagonism; Ethylamines; Imipramine; Isocitrate Dehydrogenase; Lipid Metabolism; Liver; Liver Diseases; Male; Malonates; Microsomes, Liver; Necrosis; Organ Size; Pentobarbital; Peroxidases; Peroxides; Proadifen; Rats; Sleep; Stimulation, Chemical | 1971 |
[The effect of desmethylimipramine and other "anti-tremorine" drugs on the metabolism of tremorine and oxotremorine in rats and mice].
Topics: Animals; Body Temperature; Brain; Desipramine; Drug Synergism; Imipramine; Liver; Male; Malonates; Mice; Models, Biological; Proadifen; Pyrrolidines; Rats; Receptors, Drug; Species Specificity; Thermography; Tremor; Tremorine; Tritium | 1968 |
Demethylation of imipramine in the rat as influenced by SKF 525-A and by different routes of administration.
Topics: Animals; Brain Chemistry; Female; Imipramine; In Vitro Techniques; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Methylation; Proadifen; Rats | 1968 |
The antagonism of oxotremorine effects in the mouse by thymoleptics.
Topics: Amphetamine; Animals; Desipramine; Drug Antagonism; Imipramine; Male; Mice; Proadifen; Tremorine; Trihexyphenidyl | 1966 |
Effects of methotrimeprazine, other phenothiazines and related compounds on the levels of norepinephrine in the mouse heart.
Topics: Amitriptyline; Animals; Catechols; Chlorpromazine; Hypnotics and Sedatives; Imipramine; In Vitro Techniques; Iproniazid; Male; Mice; Myocardium; Norepinephrine; Perphenazine; Phenothiazines; Proadifen; Prochlorperazine; Promazine; Trifluoperazine; Trimeprazine; Tritium | 1967 |
Phase I metabolism of imipramine by microsomes of small intestine in comparison with metabolism by liver microsomes.
Topics: Animals; Biotransformation; Guinea Pigs; Imipramine; In Vitro Techniques; Intestine, Small; Microsomes; Microsomes, Liver; Proadifen | 1983 |
The effect of chlorpromazine, metyrapone, imipramine and SKF 525-A on the hepatic first pass elimination of propranolol in the pithed rat.
Topics: Animals; Biotransformation; Chlorpromazine; Imipramine; Kinetics; Liver; Male; Metyrapone; Proadifen; Propranolol; Rats; Rats, Inbred Strains; Spinal Cord | 1982 |
Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats.
Topics: Animals; Blepharoptosis; Desipramine; Hypothermia; Imipramine; Male; Motor Activity; Proadifen; Rats; Rats, Inbred Strains; Reserpine | 1981 |
N-oxidation of imipramine by isolated perfused rat and rabbit lung.
Topics: Animals; Cytosol; Desipramine; Imipramine; Lung; Male; Microsomes; Mitochondria; Oxidation-Reduction; Perfusion; Proadifen; Rabbits; Rats; Species Specificity; Subcellular Fractions | 1980 |
Measurement and pharmacokinetic analysis of imipramine and its metabolite by brain microdialysis.
Topics: Aminopyrine; Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Half-Life; Imipramine; Male; Microdialysis; Proadifen; Rats; Rats, Wistar | 1994 |