imipramine has been researched along with mephenytoin in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 10 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brøsen, K; Gram, LF; Hallas, J; Skjelbo, E | 1 |
| Brøsen, K; Gram, LF; Kragh-Sørensen, P | 1 |
| Küpfer, A; Meyer, JW; Woggon, B | 1 |
| Brøsen, K; Madsen, H; Nielsen, KK | 1 |
| Kato, R; Yamazoe, Y | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Kim, YH; Koyama, E; Shin, JG; Shin, SG; Sohn, DR | 1 |
| Coutts, RT | 1 |
| Chiba, K; Hayashi, M; Ishizaki, T; Koyama, E; Saitoh, A; Tani, M | 1 |
| Brøsen, K; Gram, LF; Skjelbo, E | 1 |
| Chiba, K; Ishizaki, T; Kawakatsu, S; Koyama, E; Morinobu, S; Tanaka, T; Totsuka, S | 1 |
| Chiba, K; Ishizaki, T; Koyama, E; Tani, M | 1 |
3 review(s) available for imipramine and mephenytoin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Humans; Imipramine; Kinetics; Liver; Mephenytoin; Substrate Specificity | 1994 |
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.
Topics: Clomipramine; Cytochromes; Dealkylation; Depressive Disorder; Desipramine; Dextromethorphan; Drug Interactions; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Nortriptyline; Phenotype; Polymorphism, Genetic | 1994 |
13 other study(ies) available for imipramine and mephenytoin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.
Topics: Adult; Cytochrome P-450 Enzyme System; Desipramine; Female; Humans; Imipramine; Isoenzymes; Male; Mephenytoin; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1991 |
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin.
Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine | 1991 |
Importance of oxidative polymorphism on clinical efficacy and side-effects of imipramine--a retrospective study.
Topics: Debrisoquin; Depressive Disorder; Female; Humans; Imipramine; Male; Mephenytoin; Middle Aged; Oxidation-Reduction | 1988 |
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.
Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Denmark; Desipramine; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Sparteine | 1995 |
Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes.
Topics: Adult; Asian People; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Metoprolol; Mixed Function Oxygenases; Phenotype | 1994 |
The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Desipramine; Humans; Hydroxylation; Imipramine; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases | 1994 |
The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study.
Topics: Adolescent; Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic; Sparteine | 1993 |
Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Japan; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Pharmacogenetics; Phenotype | 1996 |
Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs.
Topics: Cytochrome P-450 Enzyme System; Female; Humans; Hydroxylation; Imipramine; Liver; Male; Mephenytoin; Microsomes; Middle Aged; Recombinant Proteins | 1997 |