imipramine and lidocaine

imipramine has been researched along with lidocaine in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (46.34)	18.7374
1990's	6 (7.32)	18.2507
2000's	22 (26.83)	29.6817
2010's	16 (19.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Caron, G; Ermondi, G	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Gozalbes, R; Pineda-Lucena, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Sen, S; Sinha, N	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Benveniste, J; Cazenave, JP; Mustard, JF	1
Hammarström, L; Smith, E; Waterfield, JD	1
Hollander, CS; Tai, HH	1
Hammarström, LL; Smith, CI; Waterfield, JD	1
Gustafsson, JA; Skett, P	1
Donovan, JJ; Latorre, R	1
Dolara, P; Franconi, F	1
Kelder, D; Ross, SB	1
Persson, G; Siwers, B	1
Danielson, MG; Fowler, GW; Julien, RM	1
Howell, RE; Lanken, PN	1
Fujita, S	1
Enyeart, JJ; Hinkle, PM; Phillips, WJ	1
Ahlemeyer, B; Krieglstein, J	1
Luly, P; Pacini, L; Spinedi, A	1
Bianchine, JR; Gerber, MC; Gerber, N; Tejwani, GA	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Wood, M	1
Dill, PL; Duarte, TE; Nagourney, RA; Su, YZ; Weisenthal, LM	1
Abernethy, DR; Greenblatt, DJ; Morse, DS	1
Paterson, P; Skett, P	1
Guerrero, S; Molgó, J	1
Kadzielawa, K	1
Clausen, T; Dahl-Hansen, AB; Harving, H	1
Cazenave, JP; Guccione, MA; Mustard, JF; Packham, MA	1
Chau-Wong, M; Chen, SS; Seeman, P; Staiman, A	1
Galloway, WH; Young, JA	1
Baum, T; Eckfeld, DK; Rowles, G; Shropshire, AT; Varner, LL	1
Elliott, KA; Gottesfeld, Z	1
Johansen, WG; Langslet, A; Oye, I; Ryg, M; Skomedal, T	1
Nott, MW	1
Skett, P; Young, C	1
Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR	1
Eandi, M; Ricci Gamalero, S	1
Eastwood, AB; Suarez-Kurtz, G	1
Andersson, A; Olsson, S; Tjälve, H	1
Gustafsson, JA; Mode, A; Skett, P	1
Gustafsson, JA; Mode, A; Rafter, J; Sahlin, L; Skett, P	1
Ito, Y; Kato, H; Nagata, O; Terasaki, T; Tsuji, A; Yamazaki, M; Yoshioka, K	1
Arimoto, H; Fujii, T; Kurihara, Y; Mitsutsuka, Y	1
Fujio, N; Funae, Y; Horie, T; Imaoka, S; Masubuchi, Y; Narimatsu, S; Suzuki, T; Takahashii, C	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Andreatini, R; Dombrowski, PA	1
Li, W; You, Q	1
Huang, CS; Kuo, CC; Yang, YC	1
Holland, MG; Marraffa, JM; Ryzewski, M; Sullivan, RW	1
Perry, MS; Turner, AL	1

Reviews

8 review(s) available for imipramine and lidocaine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Hypothalamo-pituitary regulation of liver function. Medical biology, 1979, Volume: 57, Issue:6 Topics: Animals; Histidine; Hypothalamo-Hypophyseal System; Imipramine; Lidocaine; Liver; Liver Function Tests; Pituitary Hormone-Releasing Hormones; Prolactin; Rats; Sex Factors	1979
[Aging and drug metabolism: alteration of liver drug metabolizing ability in male rats. Is it functional deterioration or feminization of the liver?]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:11 Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Electron Transport; Female; Feminization; Humans; Imipramine; Inactivation, Metabolic; Lidocaine; Liver; Male; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Rats; Sex Characteristics; Testosterone	1991
Drug interactions with cimetidine: an update. Pharmacology & therapeutics, 1985, Volume: 27, Issue:3 Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Aspirin; Aziridines; Benzodiazepines; Benzoquinones; Cimetidine; Drug Interactions; Humans; Ibuprofen; Imipramine; Kinetics; Lidocaine; Liver Circulation; Pituitary Gland; Procaine; Xanthines	1985
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Plasma drug binding: implications for anesthesiologists. Anesthesia and analgesia, 1986, Volume: 65, Issue:7 Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Cardiac Surgical Procedures; Chlorpromazine; Dipyridamole; Disopyramide; Etidocaine; Female; Fentanyl; Half-Life; Humans; Imipramine; Kidney Diseases; Lidocaine; Liver; Mathematics; Meperidine; Methadone; Myocardial Infarction; Orosomucoid; Prazosin; Pregnancy; Propranolol; Protein Binding; Quinidine; Serum Albumin; Sex Factors	1986
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances. Cardiology clinics, 1984, Volume: 2, Issue:1 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide	1984
Outside the box: Medications worth considering when traditional antiepileptic drugs have failed. Seizure, 2017, Volume: 50 Topics: Amantadine; Anticonvulsants; Bumetanide; Central Nervous System Stimulants; Epilepsy; Humans; Imipramine; Lidocaine; Treatment Failure; Verapamil	2017

Other Studies

74 other study(ies) available for imipramine and lidocaine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs. Laboratory investigation; a journal of technical methods and pathology, 1979, Volume: 41, Issue:3 Topics: Animals; Arachidonic Acids; Blood Platelets; Cell Membrane; Chlorpromazine; Edetic Acid; Egtazic Acid; Fibrinogen; Humans; Imipramine; Lidocaine; Methylprednisolone; Platelet Aggregation; Prostaglandins; Quinacrine; Rabbits; Reserpine; Serotonin	1979
The effect of membrane stabilizing agents on induction of the immune response. I. Effect of lymphocyte activation in mixed lymphocyte reactions. The Journal of experimental medicine, 1976, Aug-01, Volume: 144, Issue:2 Topics: Animals; Cell Division; Cell Membrane; Chlorpromazine; Imipramine; Immunity, Cellular; Lidocaine; Lymphocyte Culture Test, Mixed; Lymphocytes; Mice; Spleen	1976
Kinetic evidence of a distinct regulatory site on 15-hydroxyprostaglandin dehydrogenase. Advances in prostaglandin and thromboxane research, 1976, Volume: 1 Topics: Alcohol Oxidoreductases; Allosteric Regulation; Allosteric Site; Animals; Enzyme Activation; Ethacrynic Acid; Furosemide; Hydroxyprostaglandin Dehydrogenases; Imipramine; Kidney; Kinetics; Lidocaine; NAD; Prostaglandins E; Swine	1976
Effect of membrane stabilizing agents on induction of the immune response. II. Inhibitory effects on lymphocyte activation by B-cell mitogens parallel toxicity. Scandinavian journal of immunology, 1978, Volume: 7, Issue:2 Topics: Animals; B-Lymphocytes; Cell Membrane; Cell Survival; Cells, Cultured; Chlorpromazine; DNA; Imipramine; Lidocaine; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred Strains	1978
Inactivation of the alamethicin-induced conductance caused by quaternary ammonium ions and local anesthetics. The Journal of general physiology, 1979, Volume: 73, Issue:4 Topics: Alamethicin; Anesthetics, Local; Anti-Bacterial Agents; Cell Membrane Permeability; Imipramine; Lidocaine; Membrane Lipids; Membrane Potentials; Membranes, Artificial; Pancuronium; Quaternary Ammonium Compounds; Tetracaine	1979
Hypertonic sodium chloride and lidocaine in a case of imipramine intoxication. Clinical toxicology, 1977, Volume: 10, Issue:4 Topics: Acidosis; Child, Preschool; Electrocardiography; Humans; Hypertonic Solutions; Imipramine; Lidocaine; Male; Sodium Chloride	1977
Active transport of 3H-bretylium in the rat vas deferens in vitro. Acta physiologica Scandinavica, 1976, Volume: 97, Issue:2 Topics: Aminobenzoates; Amphetamine; Anesthetics, Local; Animals; Biological Transport, Active; Bretylium Compounds; Chlorides; Cocaine; Desipramine; Hydroxybenzoate Ethers; Hydroxydopamines; Imipramine; Lidocaine; Male; meta-Aminobenzoates; Ouabain; Rats; Reserpine; Sodium; Sympathetic Nervous System; Temperature; Vas Deferens	1976
The risk of potentiating effect of local anaesthesia with adrenalin in patients treated with tricyclic antidepressants. Svensk tandlakare tidskrift. Swedish dental journal, 1975, Volume: 68, Issue:1 Topics: Adult; Aged; Amitriptyline; Anesthesia, Local; Blood Pressure; Drug Interactions; Epinephrine; Female; Humans; Imipramine; Lidocaine; Male; Membranes; Middle Aged; Nortriptyline; Pulse; Time Factors	1975
The effects of antiepileptic drugs on estrogen-induced electrographic spike-wave discharge. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 193, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Clonazepam; Clorazepate Dipotassium; Diazepam; Electroencephalography; Estrogens; Ethosuximide; Female; Imipramine; Lidocaine; Male; Motor Cortex; Phenytoin; Stereotaxic Techniques; Trimethadione	1975
Pulmonary accumulation of propranolol in vivo: sites and physiochemical mechanism. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:1 Topics: Animals; Bronchoalveolar Lavage Fluid; Imipramine; Injections, Intravenous; Lidocaine; Lung; Lymph; Male; Propranolol; Sheep	1992
Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses. Molecular endocrinology (Baltimore, Md.), 1989, Volume: 3, Issue:9 Topics: Anesthetics, Local; Animals; Benzocaine; Chlordiazepoxide; Chlorpromazine; Dibucaine; Hydrogen-Ion Concentration; Imipramine; Lidocaine; Pituitary Gland; Procaine; Prolactin; Propranolol; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Tetracaine; Thyrotropin-Releasing Hormone; Trifluoperazine; Verapamil	1989
Testing drug effects against hypoxic damage of cultured neurons during long-term recovery. Life sciences, 1989, Volume: 45, Issue:9 Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Ischemia; Cell Count; Cell Survival; Cells, Cultured; Chick Embryo; Clonazepam; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Flunarizine; Haloperidol; Imipramine; Ketamine; Lidocaine; Nafronyl; Neurons; Pyrithioxin; Telencephalon	1989
A study of the mechanism by which some amphiphilic drugs affect human erythrocyte acetylcholinesterase activity. The Biochemical journal, 1989, Jul-15, Volume: 261, Issue:2 Topics: Acetylcholinesterase; Anesthetics, Local; Cholinesterase Inhibitors; Erythrocyte Membrane; Erythrocytes; Humans; Imipramine; Kinetics; Lidocaine; Membrane Fluidity; Procaine; Tetracaine	1989
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C. Cancer treatment reports, 1987, Volume: 71, Issue:12 Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lidocaine; Protein Kinase C; Tamoxifen; Tumor Cells, Cultured; Verapamil	1987
Methodologic factors influencing plasma binding of alpha-1-acid glycoprotein-bound and albumin-bound drugs. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:10 Topics: Dialysis; Diazepam; Drug Stability; Freezing; Humans; Imipramine; Immunodiffusion; Lidocaine; Male; Orosomucoid; Phenytoin; Protein Binding; Serum Albumin	1985
Sex differences in the effects of microsomal enzyme inducers on hepatic phase I drug metabolism in the rat. Biochemical pharmacology, 1985, Oct-01, Volume: 34, Issue:19 Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Ethanol; Female; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Sex Characteristics	1985
Effects of imipramine upon frog nerve excitability and conduction. Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 209, Issue:1 Topics: Action Potentials; Animals; Anura; Axons; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes; Hydrogen-Ion Concentration; Imipramine; In Vitro Techniques; Lidocaine; Mepivacaine; Myelin Sheath; Neural Conduction; Neurons; Refractory Period, Electrophysiological; Sciatic Nerve; Time Factors	1974
The EEG effects of dopa in the rabbit depending upon the level of brain-stem section. Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 207, Issue:2 Topics: Animals; Brain Stem; Cerebral Cortex; Cerebral Decortication; Chlorpromazine; Decerebrate State; Dihydroxyphenylalanine; Electrocardiography; Electrodes, Implanted; Electroencephalography; Gallamine Triethiodide; Haloperidol; Imipramine; Injections, Intra-Arterial; Lidocaine; Limbic System; Phenoxybenzamine; Rabbits; Stereotaxic Techniques	1974
The relationship between the transport of glucose and cations across cell membranes in isolated tissues. 8. The effect of membrane stabilizers on the transport of K + , Na + and glucose in muscle, adipocytes and erythrocytes. Biochimica et biophysica acta, 1973, Mar-16, Volume: 298, Issue:2 Topics: Adipose Tissue; Animals; Biological Transport; Blood Glucose; Carbon Isotopes; Cell Membrane; Chlorpromazine; Erythrocytes; Glucose; Imipramine; Insulin; Lidocaine; Male; Muscles; Ouabain; Potassium; Potassium Isotopes; Rats; Sodium; Sodium Isotopes; Tetracaine; Thiopental; Time Factors	1973
Inhibition of platelet adherence to a collagen-coated surface by nonsteroidal anti-inflammatory drugs, pyrimido-pyrimidine and tricyclic compounds, and lidocaine. The Journal of laboratory and clinical medicine, 1974, Volume: 83, Issue:5 Topics: Antidepressive Agents; Aspirin; Carbon Radioisotopes; Chromium Radioisotopes; Collagen; Imipramine; Lidocaine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Pyrimidines; Serotonin	1974
Calcium reversal of nerve blockade by alcohols, anesthetics, tranquilizers, and barbiturates. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Action Potentials; Alcohols; Anesthetics; Animals; Barbiturates; Benzyl Compounds; Buffers; Calcium; Carbon Radioisotopes; Chlorpromazine; Imipramine; In Vitro Techniques; Lidocaine; Membranes; Nerve Block; Neural Conduction; Pentobarbital; Phrenic Nerve; Procaine; Promethazine; Rats; Sulfur Radioisotopes; Tetrodotoxin; Thymol; Time Factors; Tranquilizing Agents	1974
Treatment of severe imipramine poisoning. Archives of disease in childhood, 1971, Volume: 46, Issue:247 Topics: Anti-Arrhythmia Agents; Anticonvulsants; Child, Preschool; Diazepam; Gastric Lavage; Humans; Imipramine; Infant; Lidocaine; Male; Poisoning	1971
Observations on models used for the evaluation of antiarrhythmic drugs. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 193, Issue:1 Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Benzazepines; Bretylium Compounds; Chlorpheniramine; Diazepam; Disease Models, Animal; Dogs; Drug Antagonism; Guinea Pigs; Imipramine; Ketones; Lidocaine; Male; Meperidine; Mephentermine; Ouabain; Phentolamine; Phenytoin; Procainamide; Promazine; Promethazine; Propranolol; Quinidine	1971
Factors that affect the binding and uptake of gaba by brain tissue. Journal of neurochemistry, 1971, Volume: 18, Issue:5 Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Bromides; Cerebral Cortex; Cevanes; Chloral Hydrate; Chlorides; Chlorpromazine; Dopamine; Glutamates; Imipramine; Iodides; Lidocaine; Neostigmine; Norepinephrine; Ouabain; Phosphates; Picrotoxin; Procaine; Rats; Sodium Chloride; Tetrodotoxin	1971
Effects of dibenzepine and imipramine on the isolated rat heart. European journal of pharmacology, 1971, Volume: 14, Issue:4 Topics: Animals; Biological Transport; Cold Temperature; Coronary Vessels; Depression, Chemical; Dibenzazepines; Drug Synergism; Electric Stimulation; Electrocardiography; Erythrocytes; Heart; Heart Conduction System; Heart Rate; Hemolysis; Hypotonic Solutions; Imipramine; In Vitro Techniques; Lidocaine; Male; Membranes; Muscle Contraction; Myocardium; Neural Conduction; Osmotic Fragility; Perfusion; Potassium; Rats; Regional Blood Flow; Stimulation, Chemical	1971
Potentiation of morphine analgesia by cocaine in mice. European journal of pharmacology, 1968, Volume: 5, Issue:1 Topics: Amphetamine; Analgesia; Animals; Cocaine; Dibucaine; Drug Synergism; Female; Imipramine; Lidocaine; Male; Mice; Morphine; Norepinephrine; Phentolamine; Procaine; Rats; Reserpine	1968
The effects of pituitary hormones on hepatic drug metabolism in the rat. Acta endocrinologica, 1982, Volume: 100, Issue:3 Topics: Animals; Diazepam; Female; Follicle Stimulating Hormone; Growth Hormone; Hypophysectomy; Imipramine; Lidocaine; Male; Microsomes, Liver; Pituitary Hormones; Prolactin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Sex Factors; Thyrotropin	1982
[Evaluation in vitro of the local anesthetic effect by means of the dose/stabilization effect curve]. Bollettino della Societa italiana di biologia sperimentale, 1980, Jan-15, Volume: 56, Issue:1 Topics: Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Imipramine; In Vitro Techniques; Lidocaine; Nerve Block; Procaine; Promazine; Rana pipiens; Sciatic Nerve	1980
Release of creatine kinase and lactate dehydrogenase from frog skeletal muscles treated with imipramine. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:2 Topics: Animals; Anura; Chlorides; Creatine Kinase; Hypertonic Solutions; Imipramine; In Vitro Techniques; L-Lactate Dehydrogenase; Lidocaine; Muscles; Procaine; Rana pipiens	1982
The uptake of 14C-chloroquine by mouse pancreatic islets in vitro. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:1 Topics: Absorption; Animals; Chloroquine; Chlorpromazine; Desipramine; Glucose; Hydrogen-Ion Concentration; Imipramine; Islets of Langerhans; Lidocaine; Mice; Nicotine; Nitrogen; Ouabain; Quinacrine; Temperature	1980
Are steroid and drug metabolic routes in the liver under similar hormonal control? [proceedings]. Biochemical Society transactions, 1980, Volume: 8, Issue:3 Topics: Animals; Castration; Female; Hypophysectomy; Imipramine; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Rats; Sex Factors	1980
The effects of gonadectomy and hypophysectomy on the metabolism of imipramine and lidocaine by the liver of male and female rats. Biochemical pharmacology, 1980, Oct-15, Volume: 29, Issue:20 Topics: Animals; Castration; Female; Hypophysectomy; Imipramine; Lidocaine; Liver; Male; Microsomes, Liver; Rats; Sex Factors	1980
Carrier-mediated transport of H1-antagonist at the blood-brain barrier: a common transport system of H1-antagonists and lipophilic basic drugs. Pharmaceutical research, 1994, Volume: 11, Issue:11 Topics: Animals; Blood-Brain Barrier; Carrier Proteins; Cattle; Cells, Cultured; Endothelium, Vascular; Histamine H1 Antagonists; Imipramine; Lidocaine; Propranolol; Pyrilamine; Solubility	1994
Surface ionization organic mass spectrometry of imipramine, desipramine, clomipramine, and lidocaine. Analytical chemistry, 1994, Jun-01, Volume: 66, Issue:11 Topics: Clomipramine; Desipramine; Humans; Imipramine; Lidocaine; Mass Spectrometry; Sensitivity and Specificity; Surface Properties	1994
Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:9 Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ferricyanides; Imipramine; Immunoblotting; Isoenzymes; Lidocaine; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Propranolol; Rats; Rats, Wistar; Testosterone	1995
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
Reversible inactivation of the dorsal raphe nucleus blocked the antipanic-like effect of chronic imipramine in the elevated T-maze. Neuroscience letters, 2006, Oct-16, Volume: 407, Issue:1 Topics: Analysis of Variance; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Drug Administration Routes; Drug Interactions; Imipramine; Lidocaine; Male; Maze Learning; Raphe Nuclei; Rats; Rats, Wistar; Reaction Time; Time Factors	2006
Synthesis and local anesthetic activity of fluoro-substituted imipramine and its analogues. Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13 Topics: Anesthetics, Local; Animals; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Electrophysiology; Fluorine; Hydrogen-Ion Concentration; Imipramine; Kinetics; Lidocaine; Models, Chemical; Nerve Block; Neurons; Ranidae; Sciatic Nerve	2007
Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels. Anesthesiology, 2010, Volume: 113, Issue:1 Topics: Anesthetics, Local; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Binding Sites; Brain; Carbamazepine; Drug Synergism; Imipramine; Lidocaine; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channels	2010
Compounded ointment results in severe toxicity in a pediatric patient. Pediatric emergency care, 2013, Volume: 29, Issue:11 Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined Modality Therapy; Consciousness Disorders; Cyclohexanecarboxylic Acids; Diaper Rash; Drug Combinations; Drug Compounding; Drug Overdose; Emergencies; Gabapentin; gamma-Aminobutyric Acid; Humans; Imipramine; Infant; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Lidocaine; Male; Mefenamic Acid; Ointments; Reflex, Abnormal; Respiration Disorders; Skin Absorption	2013