imipramine has been researched along with isomethyleugenol in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (59.46) | 18.7374 |
| 1990's | 10 (27.03) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gescher, A; Li Wan Po, A | 1 |
| Johansson, R; Nagy, A | 1 |
| Christiansen, J; Gram, LF | 1 |
| Randall, PK; Taylor, KM | 1 |
| Melzacka, M; Nocon, H | 2 |
| Bures, P; Fuksová, K; Krulík, R; Sikora, J | 1 |
| Brøsen, K; Gram, LF; Hallas, J; Skjelbo, E | 1 |
| Hölzl, G; Krüger, R; Kuss, HJ; Schefold, L | 1 |
| Brøsen, K; Gram, LF; Otton, SV | 1 |
| Narasimhachari, N | 1 |
| Hackenberg, H; Krieglstein, J | 1 |
| Clark, B; Thompson, JW; Widdrington, G | 1 |
| Angelo, LS; Junod, AF; Nicholas, TE; Strum, JM | 1 |
| Horn, AS; Trace, RC | 1 |
| Lin, RL; Narasimhachari, N | 1 |
| Scheel-Krüger, J | 1 |
| Efron, DH; Gaudette, LE; Harris, SR; Manian, AA | 1 |
| Nakazawa, K | 1 |
| Ahtee, L; Paasonen, MK | 1 |
| Bickel, MH; Weder, HJ | 1 |
| Suchanek-Fröhlich, H | 1 |
| Daniel, W; Friebertshäuser, J; Steffen, C | 1 |
| Ettigi, P; Friedel, RO; Joseph, A; Narasimhachari, N; Saady, JJ | 1 |
| Wahba, WW; Winek, CL; Zaveri, NR | 1 |
| Baker, GB; Coutts, RT; Daneshtalab, M; Su, P | 1 |
| Janczar, L; Melzacka, M; Nocon, H | 1 |
| Brøsen, K; Madsen, H; Rasmussen, BB | 1 |
| Huang, SL; Wang, JS; Wang, W; Xie, HG; Zhou, HH | 1 |
| Brzezinski, MR; Chen, H; Fantel, AG; Juchau, MR | 1 |
| Daniel, WA; Haduch, A; Syrek, M; Wójcikowski, J | 1 |
| PSCHEIDT, GR | 1 |
| AXELROD, J; SNYDER, SH | 1 |
| Berton, O; Kumar, A; Nestler, EJ; Neve, RL; Renthal, W; Tsankova, NM | 1 |
| Bobadilla Lugo, RA; Pérez-Alvarez, V; Sánchez-Ortiz, R | 1 |
| Kodadek, TJ; Kumar, A; LaPlant, Q; Nestler, EJ; Renthal, W; Sikder, D; Wilkinson, MB; Xiao, G | 1 |
| Sakurai, E; Ueda, Y; Yaginuma, T | 1 |
1 trial(s) available for imipramine and isomethyleugenol
| Article | Year |
|---|---|
Effect of troleandomycin on the pharmacokinetics of imipramine in Chinese: the role of CYP3A.
Topics: Adult; Anti-Bacterial Agents; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Imipramine; Male; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Reference Values; Troleandomycin | 1997 |
36 other study(ies) available for imipramine and isomethyleugenol
| Article | Year |
|---|---|
Correlation of physicochemical properties with absorption and metabolism of some tricyclic drugs.
Topics: Absorption; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Doxepin; Imipramine; In Vitro Techniques; Male; Methylation; Phenothiazines; Promazine; Promethazine; Rats; Surface Tension | 1978 |
The demethylation of imipramine and clomipramine as apparent from their plasma kinetics.
Topics: Administration, Oral; Adult; Biotransformation; Clomipramine; Dibenzazepines; Female; Half-Life; Humans; Imipramine; Injections, Intramuscular; Kinetics; Male; Methylation | 1977 |
First-pass metabolism of imipramine in man.
Topics: Administration, Oral; Adult; Biological Availability; Desipramine; Female; Glucuronates; Half-Life; Humans; Imipramine; Injections, Intravenous; Liver Circulation; Male; Methylation; Middle Aged; Time Factors | 1975 |
Depletion of S-adenosyl-L-methionine in mouse brain by antidepressive drugs.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain Chemistry; Cycloleucine; Depression, Chemical; Histamine N-Methyltransferase; Imipramine; Male; Methylation; Mice; Norepinephrine; S-Adenosylmethionine | 1975 |
Effect of some cationic amphiphilic drugs on phospholipid methylation in the central nervous system of rats.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Citalopram; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Methylation; Methyltransferases; Phospholipids; Rats; Rats, Inbred Strains; Synaptic Membranes | 1991 |
Effect of imipramine on the membrane anisotropy and on the phospholipid methylation in the central nervous system of the rat.
Topics: Animals; Anisotropy; Brain; Cell Membrane; Imipramine; Injections, Intraperitoneal; Male; Methylation; Phospholipids; Rats; Rats, Inbred Strains | 1991 |
Methylated and demethylated tricyclic antidepressants and their binding to cell membranes.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Cattle; Cell Membrane; Dealkylation; Desipramine; Erythrocyte Membrane; Imipramine; In Vitro Techniques; Lymphocytes; Methylation; Phosphatidylserines; Phospholipids; Synaptic Membranes | 1991 |
The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.
Topics: Adult; Cytochrome P-450 Enzyme System; Desipramine; Female; Humans; Imipramine; Isoenzymes; Male; Mephenytoin; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1991 |
Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes.
Topics: Amitriptyline; Animals; Chemical Phenomena; Chemistry; Clomipramine; Female; Hydroxylation; Imipramine; In Vitro Techniques; Methylation; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1986 |
Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype.
Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Methylation; Oxidation-Reduction; Phenotype; Sparteine | 1986 |
Tricyclic antidepressants in vivo methylation: response to Lydiard and co-workers.
Topics: Amoxapine; Animals; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Kinetics; Loxapine; Methylation; Rabbits | 1986 |
Comparative study on the inhibition of Na + , K + -activated ATPase activity by chlorpromazine, promazine, imipramine, and their monodesmethyl metabolites.
Topics: Adenosine Triphosphatases; Animals; Brain; Chlorpromazine; Enzyme Activation; Female; Imipramine; Methylation; Microsomes; Potassium; Promazine; Protein Binding; Rats; Receptors, Drug; Sodium | 1972 |
Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man.
Topics: Amphetamine; Animals; Chlorpromazine; Desipramine; Drug Interactions; Histamine; Hydrazines; Hydrocortisone; Imipramine; Iproniazid; Male; Meperidine; Methylation; Microsomes, Liver; Monoamine Oxidase Inhibitors; Nialamide; Opipramol; Phenothiazines; Phenylhydrazines; Prednisolone; Proadifen; Promazine; Rats; Transferases | 1972 |
Site and mechanism of uptake of 3H--norepinephrine by isolated perfused rat lungs.
Topics: Animals; Autoradiography; Cocaine; Deamination; Endothelium; Imipramine; Lung; Metaraminol; Methylation; Microscopy, Electron; Muscle, Smooth; Neurons; Norepinephrine; Normetanephrine; Ouabain; Potassium; Rats; Serotonin; Sodium; Temperature; Tritium | 1974 |
Structure-activity relations for the inhibition of 5-hydroxytryptamine uptake by tricyclic antidepressants into synaptosomes from serotoninergic neurones in rat brain homogenates.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Chlorpromazine; Hypothalamus; Imipramine; In Vitro Techniques; Iprindole; Methylation; Neurons; Nortriptyline; Promazine; Rats; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Synaptosomes | 1974 |
A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Hallucinogens; Humans; Imipramine; In Vitro Techniques; Indoles; Lung; Mass Spectrometry; Methylation; Methyltransferases; N,N-Dimethyltryptamine; Rabbits; S-Adenosylmethionine; Schizophrenia; Serotonin; Solvents; Tetrahydrofolates; Time Factors; Tryptamines | 1974 |
Studies on the accumulation of O-methylated dopamine and noradrenaline in the rat brain following various neuroleptics, thymoleptics and aceperone.
Topics: Acetamides; Animals; Antidepressive Agents; Benzimidazoles; Brain; Brain Chemistry; Butyrophenones; Chlorpromazine; Chlorprothixene; Desipramine; Dopamine; Imipramine; Ketones; Male; Methylation; Norepinephrine; Normetanephrine; Pargyline; Piperidines; Rats; Stimulation, Chemical; Tranquilizing Agents; Tyramine | 1972 |
A method for the measurement of plasma imipramine and desmethylimipramine concentrations.
Topics: Acetates; Animals; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry; Desipramine; Dogs; Imipramine; Methods; Methylation; Tritium | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Potentiation of 5-hydroxytryptamine release from platelets by desmethylation of chlorpromazine and related agents.
Topics: Amitriptyline; Animals; Blood Platelets; Chlorpromazine; Drug Synergism; Imipramine; Methylation; Nortriptyline; Rabbits; Serotonin | 1968 |
Demethylation of imipramine in the rat as influenced by SKF 525-A and by different routes of administration.
Topics: Animals; Brain Chemistry; Female; Imipramine; In Vitro Techniques; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Male; Methylation; Proadifen; Rats | 1968 |
[The therapy of depressions with Trimeprimine, a methylated imipramine].
Topics: Adult; Aged; Animals; Depression; Female; Humans; Imipramine; Male; Methylation; Middle Aged | 1967 |
The effect of imipramine and desipramine on mixed function oxidase in rats.
Topics: Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Liver; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Rats; Rats, Inbred Strains | 1984 |
Evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans.
Topics: Amitriptyline; Biotransformation; Depressive Disorder; Desipramine; Humans; Imipramine; Methylation; Nortriptyline | 1982 |
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation Studies as Topic; Forensic Medicine; Formaldehyde; Humans; Imipramine; Liver; Methylation; Nortriptyline; Poisoning; Temperature; Time Factors | 1993 |
Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line.
Topics: Catalysis; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Humans; Imipramine; Isoenzymes; Methylation; Mixed Function Oxygenases; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity | 1993 |
The effects of imipramine on the methylation of phosphatidylethanolamine (PE) in the cortical membranes of Wistar rats.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Imipramine; Male; Membranes; Methylation; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Wistar; Time Factors | 1993 |
Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4.
Topics: Adult; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Imipramine; Male; Methylation; Mixed Function Oxygenases; Phenotype; Regression Analysis | 1997 |
Catalysis of drug oxidation during embryogenesis in human hepatic tissues using imipramine as a model substrate.
Topics: Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Embryonic and Fetal Development; Humans; Imipramine; Isoenzymes; Liver; Methylation; Oxidation-Reduction | 1999 |
Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Brain; Cytochrome P-450 Enzyme System; Drug Interactions; Imipramine; Male; Methylation; Microsomes, Liver; Oxidation-Reduction; Perazine; Rats; Rats, Wistar; Time Factors | 2000 |
Demethylation of imipramine in male and female rats.
Topics: Animals; Female; Imipramine; Male; Methylation; Rats | 1962 |
INHIBITION OF HISTAMINE METHYLATION IN VIVO BY DRUGS.
Topics: Carbon Isotopes; Chlorpromazine; Chromatography; Guanidines; Hallucinogens; Histamine; Histamine Release; Hydrazines; Imipramine; Indoles; Metabolism; Methylation; Mice; Pharmacology; Research; Reserpine; Serotonin; Tripelennamine | 1964 |
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action.
Topics: Acetylation; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chromatin; Depression; Disease Models, Animal; Hippocampus; Histones; Imipramine; Male; Methylation; Mice; Mice, Inbred C57BL; Stress, Psychological | 2006 |
Vasoactive properties of antidepressant N-alkyl derivatives.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Fluoxetine; Imipramine; Male; Methylation; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship | 2007 |
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatin; Chromatin Immunoprecipitation; CREB-Binding Protein; Depression; Disease Models, Animal; Dominance-Subordination; Gene Expression; Genome-Wide Association Study; Histones; Imipramine; Male; Methylation; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Social Isolation | 2009 |
N-demethylation and N-oxidation of imipramine in rat thoracic aortic endothelial cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Endothelial Cells; Imipramine; Male; Methylation; Oxidation-Reduction; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase; Thoracic Arteries | 2014 |