imipramine has been researched along with imipramine n-oxide in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (45.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Kitamura, S; Mishima, HK; Nikaido, H; Shimada, S; Tatsumi, K | 1 |
| Kitamura, S; Mishima, H; Shimada, S; Tatsumi, K | 1 |
| Norén, MB; Pedersen, F; Rapp, W | 1 |
| Kitamura, S; Tatsumi, K | 2 |
| Bjerre, M; Gram, LF; Kragh-Sørensen, P; Kvinesdal, B; Molin, J; Pedersen, OL; Reisby, N | 1 |
| Nagy, A | 1 |
| Mehendale, HM; Ohmiya, Y | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Kikuchi, Y; Koyama, E | 1 |
| Bhagwat, SV; Bhamre, S; Boyd, MR; Ravindranath, V | 1 |
| Inoue, N; Kamio, H; Kitamura, S; Ohta, S; Tatsumi, K; Terada, A | 1 |
| Kitamura, S; Sugihara, K; Tatsumi, K | 1 |
| Hansen, SH; Tjørnelund, J | 1 |
| Horie, T; Kato, R; Koitabashi, T; Masubuchi, Y; Narimatsu, S; Suzuki, T; Yamamoto, S | 1 |
| Kitamura, S; Ohta, S; Sugihara, K; Takekawa, K | 1 |
| FAURBYE, A; JACOBSEN, O; KRISTJANSEN, P; MUNKVAD, I | 1 |
| LARSEN, V | 1 |
| Chandan, P; Hernandez, D; Janmohamed, A; Omar, BA; Phillips, IR; Shephard, EA | 1 |
| Sakurai, E; Ueda, Y; Yaginuma, T | 1 |
1 trial(s) available for imipramine and imipramine n-oxide
| Article | Year |
|---|---|
Comparative trial of imipramine N-oxide and imipramine in the treatment of out-patients with depressive syndromes.
Topics: Adult; Clinical Trials as Topic; Depression; Evaluation Studies as Topic; Female; Humans; Imipramine; Liver Function Tests; Male; Middle Aged; Nitrogen Oxides; Outpatient Clinics, Hospital; Sweating; Vertigo; Xerostomia | 1973 |
19 other study(ies) available for imipramine and imipramine n-oxide
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Metabolism of drugs in the eye. Menadione-dependent reduction of tertiary amine N-oxide by preparations from bovine ocular tissues.
Topics: Animals; Cattle; Ciliary Body; Cytosol; Eye; Imipramine; Microsomes; NADP; Oxidation-Reduction; Oxidoreductases; Quinone Reductases; Vitamin K | 1989 |
Metabolism of drugs in the eye. Drug-reducing activity of preparations from bovine ciliary body.
Topics: Aldehyde Oxidoreductases; Animals; Cattle; Ciliary Body; Cytosol; Eye; Imipramine; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes; NADH, NADPH Oxidoreductases; Oxidoreductases; Vitamin K | 1988 |
Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Amines; Amitriptyline; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Cytosol; Dibenzocycloheptenes; Imipramine; Liver; Mice; Microsomes, Liver; Oxidation-Reduction; Rabbits; Rats; Species Specificity; Substrate Specificity; Swine | 1984 |
Imipramine metabolites in blood of patients during therapy and after overdose.
Topics: Adult; Aged; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged | 1983 |
On the kinetics of imipramine and related antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Desipramine; Half-Life; Humans; Imipramine; Kinetics; Rats | 1980 |
N-oxidation of imipramine by isolated perfused rat and rabbit lung.
Topics: Animals; Cytosol; Desipramine; Imipramine; Lung; Male; Microsomes; Mitochondria; Oxidation-Reduction; Perfusion; Proadifen; Rabbits; Rats; Species Specificity; Subcellular Fractions | 1980 |
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti
Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electrochemistry; Glucuronidase; Humans; Hydroxylation; Imipramine; Male; Oxidation-Reduction; Phenotype; Psychotropic Drugs; Sensitivity and Specificity; Sparteine; Time Factors; Tranquilizing Agents | 1993 |
Further characterization of rat brain flavin-containing monooxygenase. Metabolism of imipramine to its N-oxide.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Detergents; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Imipramine; Kinetics; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygenases; Rabbits; Rats; Rats, Wistar; Sodium Dodecyl Sulfate; Temperature | 1996 |
Menadione-dependent reduction of tertiary amine N-oxide by rat liver cytosol.
Topics: Animals; Arsenites; Carbon Monoxide; Catalase; Cytosol; Dicumarol; Hemin; Hemoglobins; Imipramine; Liver; Male; Myoglobin; NAD; NADP; Oxidation-Reduction; Potassium Cyanide; Rats; Rats, Wistar; Sodium Compounds; Vitamin K | 1997 |
Quinone-dependent tertiary amine N-oxide reduction in rat blood.
Topics: Animals; Antidepressive Agents, Tricyclic; Heme; Imipramine; In Vitro Techniques; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Rats; Rats, Wistar; Time Factors | 1998 |
A unique tertiary amine N-oxide reduction system composed of quinone reductase and heme in rat liver preparations.
Topics: Animals; Cricetinae; Cytosol; Guinea Pigs; Heme; Imipramine; Liver; Male; Mesocricetus; Mice; Microsomes, Liver; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Rabbits; Rats; Rats, Wistar | 1999 |
Non-aqueous capillary electrophoresis of drugs: properties and application of selected solvents.
Topics: 4-Aminobenzoic Acid; Acetonitriles; Aminobenzoates; Carbonates; Desipramine; Dimethyl Sulfoxide; Dimethylformamide; Electrophoresis, Capillary; Formamides; Hydrogen-Ion Concentration; Ibuprofen; Imipramine; Methanol; Models, Statistical; Organic Chemicals; ortho-Aminobenzoates; Propane; Solvents; Temperature; Time Factors; Viscosity; Water | 1999 |
Biphasic kinetics of imipramine N-oxidation in rat brain microsomes.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Female; Imipramine; Kinetics; Male; Microsomes; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Tranquilizing Agents | 1999 |
Non-enzymatic reduction of aliphatic tertiary amine N-oxides mediated by the haem moiety of cytochrome P450.
Topics: Amines; Animals; Catalysis; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Flavins; Heme; Imipramine; In Vitro Techniques; Male; Microsomes, Liver; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Rats; Rats, Sprague-Dawley; Strychnine | 2001 |
Imipramine-N-oxide: preliminary investigation of a new antidepressive drug.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Imipramine | 1963 |
THE TERATOGENIC EFFECTS OF THALIDOMIDE, IMIPRAMINE HC1 AND IMIPRAMINE-N-OXIDE HC1 ON WHITE DANISH RABBITS.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetal Diseases; Humans; Imipramine; Lagomorpha; Pharmacology; Pregnancy; Rabbits; Research; Teratogenesis; Thalidomide; Toxicology | 1963 |
Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cells, Cultured; Chromosomes; Embryonic Stem Cells; Female; Gene Deletion; Heterozygote; Homozygote; Imipramine; Integrases; Male; Mice; Oxygenases; Spasm; Transfection; Tremor | 2009 |
N-demethylation and N-oxidation of imipramine in rat thoracic aortic endothelial cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Endothelial Cells; Imipramine; Male; Methylation; Oxidation-Reduction; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase; Thoracic Arteries | 2014 |