imipramine and flecainide

imipramine has been researched along with flecainide in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (22.22)	18.7374
1990's	2 (7.41)	18.2507
2000's	10 (37.04)	29.6817
2010's	9 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Sen, S; Sinha, N	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Dalvie, D; Loi, CM; Smith, DA	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Barker, AH; Capone, RJ; Echt, DS; Greene, HL; Hallstrom, AP; McBride, R; Richardson, DW; Roden, DM	1
Anderson, JL; Barker, AH; Fowles, RE; Griffith, LS; Hallstrom, AP; Ledingham, RB; Reiffel, JA; Young, JB; Yusuf, S	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Dougherty, AH; Naccarelli, GV; Wiggins, S; Wolbrette, D	1

Reviews

3 review(s) available for imipramine and flecainide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances. Cardiology clinics, 1984, Volume: 2, Issue:1 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide	1984

Trials

4 trial(s) available for imipramine and flecainide

Article	Year
Recruitment and baseline description of patients in the Cardiac Arrhythmia Pilot Study. The Cardiac Arrhythmia Pilot Study (CAPS) investigators. The American journal of cardiology, 1988, Apr-01, Volume: 61, Issue:10 Topics: Anilides; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Electrocardiography; Encainide; Feasibility Studies; Female; Flecainide; Humans; Imipramine; Male; Middle Aged; Moricizine; Myocardial Infarction; Phenothiazines; Pilot Projects; Random Allocation; Stroke Volume; United States	1988
Congestive heart failure after acute myocardial infarction in patients receiving antiarrhythmic agents for ventricular premature complexes (Cardiac Arrhythmia Pilot Study). The American journal of cardiology, 1989, Feb-15, Volume: 63, Issue:7 Topics: Anilides; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Double-Blind Method; Encainide; Female; Flecainide; Heart Failure; Humans; Imipramine; Male; Middle Aged; Moricizine; Myocardial Infarction; Phenothiazines; Random Allocation; Stroke Volume	1989
Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction. Circulation, 1989, Volume: 79, Issue:3 Topics: Anilides; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Encainide; Flecainide; Humans; Imipramine; Moricizine; Multicenter Studies as Topic; Myocardial Infarction; Phenothiazines; Pilot Projects; Random Allocation; Statistics as Topic; Stroke Volume	1989
Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS. The American journal of cardiology, 1988, Mar-01, Volume: 61, Issue:8 Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Encainide; Female; Flecainide; Heart Failure; Humans; Imipramine; Male; Middle Aged; Moricizine; Myocardial Infarction; Phenothiazines; Random Allocation; Stroke Volume	1988

Other Studies

20 other study(ies) available for imipramine and flecainide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
A critical appraisal of the cardiac arrhythmia suppression trial (CAST). Applied cardiopulmonary pathophysiology : ACP, 1991, Volume: 4, Issue:1 Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Encainide; Flecainide; Humans; Imipramine; Moricizine; Multicenter Studies as Topic; Pilot Projects; Randomized Controlled Trials as Topic; Risk Factors	1991