imipramine and doxepin

imipramine has been researched along with doxepin in 115 studies

Research

Studies (115)

Timeframe	Studies, this research(%)	All Research%
pre-1990	73 (63.48)	18.7374
1990's	15 (13.04)	18.2507
2000's	18 (15.65)	29.6817
2010's	8 (6.96)	24.3611
2020's	1 (0.87)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Beard, CC; Dvorak, C; Marx, M; Patterson, J; Roszkowski, A; Schuler, M; Unger, SH; Wagner, PJ; Wallach, MB; Weinhardt, K	1
Ciganek, E; Cohen, M; Smith, DH; Uyeda, RT	1
Medina-Hernández, MJ; Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM	1
Strassburg, CP; Tukey, RH	1
Topliss, JG; Yoshida, F	1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Gescher, A; Li Wan Po, A	1
Hollister, LE	1
Richelson, E	1
Levine, RM; Maickel, RP; Spaulding, JH; Zabik, JE	1
Goldstein, FJ; Tehrani, JB; Victor Rossi, G	1
Roth, JA	1
Cole, JO; Finnerty, RJ; Goldberg, HL; Rickels, K	1
Avery, GS; Brogden, RN; Pinder, RM; Speight, TM	1
Habermann, W	1
Amin, MM; Ban, TA; Lehmann, HE; Marcotte, E	1
Dorrity, F; Jobson, K; Linnoila, M	1
Dujovne, CA; Ueda, I; Yasuhara, H	1
Simmons, EC	1
Brown, TC; Leversha, A	1
Biggs, JT; Petit, JM; Spiker, DG; Ziegler, VE	1
Huey, LY; Janowsky, DS; Risch, SC	1
Lohmann, HJ; Miles, DG; Proelss, HF	1
Finnerty, RJ; Goldberg, HL; Rickels, K	1
Biggs, JT; Petit, JM	1
Burrows, GD; Davies, B; Hunt, D; Scoggins, BA; Sloman, JG; Vohra, J	1
Burrows, GD; Sloman, G; Vohra, J	1
Vanggaard, T	1
Fujimoto, K; Ookuma, K; Sakata, T	1
Bakish, D; Hrdina, PD; Lapierre, YD; Swenson, S	1
Deptula, D; Pomara, N	1
Delen, FM; Ehlert, FJ; Liem, HA; Yun, SH	1
Jones, GR; Pounder, DJ	1
Fellhauer, M	1
Balon, R; Berchou, R; Ortiz, A; Pohl, R; Rainey, JM; Yeragani, VK	1
Chaleby, K; el-Yazigi, A	1
Borbe, HO; Dimpfel, W; Spüler, M	1
Davis, CM; Ereshefsky, L; LeRoy, A; Tran-Johnson, T	1
Balon, R; Lycaki, H; Pohl, R; Yeragani, VK	1
Cunha, UV	1
Mahapatra, D; Mahapatra, RK; Paul, SK; Winter, S	1
Callies, AL; Popkin, MK	1
Fisch, C	1
Chamberlain, K; Curtis, G; Falcon, S; Ryan, C	1
Blake, DJ	1
Schneider, LS	1
Dysken, MW; Lyons, JS; Rosen, AJ	1
Field, FP; Simpkins, JW; Soltis, EE; Torosian, G	1
Aldrich, J; Conolly, ME; Gerner, R; Hill, M; Jarvik, LF; Joseph, J; Linde, S; Mintz, J; Neshkes, RE; Rosen, R	1
Tuomisto, J	1
McNair, DM	1
Lassen, JB	1
Mattila, MJ; Saarnivaara, L	1
Nowak, JZ; Zawilska, J	1
Reilly, MA; Sigg, EB	1
Fairchild, MD; Jenden, DJ; Mickey, MR; Yale, C	1
Jarvik, LF; Mintz, J; Neshkes, RE; Read, SL	1
Caillé, G; Cournoyer, G; de Montigny, C; Langlois, R; Morissette, R	1
Holmberg, G	1
Brotman, AW; Jenike, MA	1
Akiskal, HS; Arana, GW; Baldessarini, RJ; Barreira, PJ	1
Beierle, FA; Hubbard, RW	1
Cassone, MC; Fundarò, A; Molinengo, L	1
Asnis, GM; Endicott, J; Halbreich, U; Nathan, RS; Novacenko, H; Ostrow, L; Sachar, EJ	1
Barnes, RF; Gumbrecht, G; Halter, JB; Raskind, MA; Ritchie, JL; Veith, RC	1
Evans, BD; Marcovici, M; McLellan, AT; O'Brien, CP; Woody, GE	1
Amsterdam, J; Brunswick, D; Mendels, J	1
Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC	1
Forker, AD; Marshall, JB	1
Ban, TA; Guy, W; McEvoy, JP; Petrie, WM; Schaffer, JD; Wilson, WH	1
Lyskowksi, J; Nasrallah, HA; Schroeder, D	1
Duraković, Z; Gasparović, V; Gjurasin, M; Ivanović, D; Plavsić, F	1
Gerner, R; Jarvik, LF; Mintz, J; Steuer, J	1
Friedel, RO	1
Kabra, PM; Mar, NA; Marton, LJ	1
Bannister, SJ; Dolan, JW; Snyder, LR; van der Wal, S	1
Finnerty, RJ; Goldberg, HL	1
Lindsay, PG; Wyckoff, M	1
Klein, DF	1
Brennan, FJ	1
Andrasik, F; Bellack, AS; Capparell, HV; Hersen, M; Turner, SM	1
Albus, M; Scheibe, G; Scherer, J	2
Beneke, M; Fritze, J; Rasmus, W; Rød, IS	1
Albus, M; Scheibe, G	2
Irman-Florjanc, T; Stanovnik, L	1
Lu, W; McCarley, TD; Shamsi, SA; Warner, IM	1
Graham, BG; Sattely-Miller, EA; Schiffman, SS; Suggs, MS	1
Casarotto, MG; Craik, DJ	1
Barańczyk-Kuźma, A; Jagiełło, J; Kuźma, M; Sawicki, J	1
Arias, HR; Bouzat, C; Gumilar, F; Spitzmaul, G	1
Bateman, DN; Chick, J; Good, AM; Kelly, CA; Masterton, G	1
Barańczyk-Kuźma, A; Gutowicz, M; Kaźmierczak, B; Kuźma, M; Sawicki, J	1
Amitai, Y; Frischer, H	1
Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK	1
Nika, MK; Papadoyannis, IN; Samanidou, VF	1
Bouzat, C; Gumilar, F	1
Campmany, AC; Campos, FF; Naveros, BC; Sandig, AG; Villena, MJ	1
Baik, HJ; Chung, RK; Kim, DY; Lee, GY; Park, HJ; Woo, JH; Zuo, Z	1
Caldara, M; Marmiroli, N	1
Augusti, R; Nascentes, CC; Oliveira, FM; Scheel, GL; Tarley, CRT	1

Reviews

11 review(s) available for imipramine and doxepin

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Tricyclic antidepressants (first of two parts). The New England journal of medicine, 1978, Nov-16, Volume: 299, Issue:20 Topics: Aged; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical Phenomena; Chemistry; Child; Depression; Desipramine; Doxepin; Humans; Imipramine; Kinetics; Neurotransmitter Agents; Nortriptyline; Protriptyline	1978
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression. Drugs, 1977, Volume: 13, Issue:3 Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Interactions; Female; Humans; Imipramine; Kinetics; Menopause; Sleep Wake Disorders; Substance-Related Disorders	1977
A review of controlled studies with nomifensine, performed outside the UK. British journal of clinical pharmacology, 1977, Volume: 4Suppl 2 Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Drug Evaluation; Humans; Imipramine; Isoquinolines; Nomifensine; Placebos; Viloxazine	1977
Effects of antidepressants on human performance: a review. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:2 Topics: Age Factors; Amitriptyline; Antidepressive Agents; Depressive Disorder; Doxepin; Humans; Imipramine; Psychomotor Performance; Reference Values	1990
Steady-state kinetics of doxepin and imipramine in Saudi patients with interethnic comparison. Psychopharmacology, 1988, Volume: 95, Issue:1 Topics: Adolescent; Adult; Depressive Disorder; Doxepin; Europe; Female; Humans; Imipramine; Male; Middle Aged; Saudi Arabia; United States; White People	1988
Pharmacokinetic factors affecting antidepressant drug clearance and clinical effect: evaluation of doxepin and imipramine--new data and review. Clinical chemistry, 1988, Volume: 34, Issue:5 Topics: Aged; Algorithms; Antidepressive Agents, Tricyclic; Doxepin; Drug Interactions; Feeding Behavior; Female; Humans; Imipramine; Middle Aged; Protein Binding; Smoking; Splanchnic Circulation	1988
Self-evaluations of antidepressants. Psychopharmacologia, 1974, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine	1974
The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. The American journal of psychiatry, 1980, Volume: 137, Issue:6 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Doxepin; Heart; Humans; Imipramine; Nortriptyline; Protriptyline	1980
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications. American heart journal, 1982, Volume: 103, Issue:3 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; Child; Depression; Desipramine; Doxepin; Electrocardiography; Hemodynamics; Humans; Hypotension; Imipramine; Kinetics; Middle Aged; Myocardium; Norepinephrine; Parasympatholytics; Protriptyline	1982

Trials

20 trial(s) available for imipramine and doxepin

Article	Year
Research activity by private practive psychiatrists. Collaborative studies in private practice [proceedings]. Psychopharmacology bulletin, 1977, Volume: 13, Issue:1 Topics: Adjustment Disorders; Adult; Clinical Trials as Topic; Doxepin; Female; Humans; Imipramine; Male; Private Practice; Psychopharmacology; Research	1977
A review of controlled studies with nomifensine, performed outside the UK. British journal of clinical pharmacology, 1977, Volume: 4Suppl 2 Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Drug Evaluation; Humans; Imipramine; Isoquinolines; Nomifensine; Placebos; Viloxazine	1977
Doxepin and imipramine in the treatment of depression: a double-blind crossover clinical study with EKG recordings. Psychopharmacology bulletin, 1978, Volume: 14, Issue:1 Topics: Adjustment Disorders; Adult; Bipolar Disorder; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin; Electrocardiography; Female; Humans; Imipramine; Male; Middle Aged	1978
Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients. The American journal of psychiatry, 1978, Volume: 135, Issue:5 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Biopharmaceutics; Clinical Trials as Topic; Depression; Desipramine; Doxepin; Erythrocytes; Humans; Imipramine; Middle Aged; Nortriptyline	1978
Doxepin versus imipramine in psychoneurotic depressed patients with sleep disturbance: a double-blind study. The Journal of clinical psychiatry, 1978, Volume: 39, Issue:12 Topics: Adjustment Disorders; Adult; Aged; Anxiety; Cognition; Double-Blind Method; Doxepin; Drug Evaluation; Female; Hostility; Humans; Imipramine; Male; Middle Aged; Psychological Tests; Self-Assessment; Sleep Wake Disorders	1978
Sodium lactate infusions after treatment with tricyclic antidepressants: behavioral and physiological findings. Biological psychiatry, 1988, Volume: 24, Issue:7 Topics: Antidepressive Agents, Tricyclic; Arousal; Clinical Trials as Topic; Desipramine; Double-Blind Method; Doxepin; Fear; Humans; Imipramine; Isoproterenol; Lactates; Lactic Acid; Nortriptyline; Panic; Psychological Tests	1988
Tricyclics: possible treatment for posttraumatic stress disorder. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:9 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Combat Disorders; Desipramine; Doxepin; Humans; Imipramine; Male; Manuals as Topic; Middle Aged; Psychiatric Status Rating Scales; Retrospective Studies; Stress Disorders, Post-Traumatic	1985
Behavioral effects of tricyclic drugs in depressed inpatients. Journal of consulting and clinical psychology, 1985, Volume: 53, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Doxepin; Female; Humans; Imipramine; Male; Psychological Tests; Social Behavior	1985
Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:2 Topics: Age Factors; Aged; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Hypotension, Orthostatic; Imipramine; Male; Middle Aged	1985
Self-evaluations of antidepressants. Psychopharmacologia, 1974, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine	1974
Pretreatment orthostatic hypotension in geriatric depression: predictor of response to imipramine and doxepin. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:6 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Hypotension, Orthostatic; Imipramine; Male; Middle Aged; Prognosis	1983
Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system. Archives of general psychiatry, 1983, Volume: 40, Issue:12 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doxepin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Lithium; Lithium Carbonate; Male; Middle Aged; Neurons; Psychiatric Status Rating Scales; Serotonin; Trimipramine	1983
Critical flicker fusion (CFF) test for sedative effect of antidepressants. Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290 Topics: Adult; Amitriptyline; Antidepressive Agents; Arousal; Brompheniramine; Doxepin; Female; Flicker Fusion; Humans; Hypnotics and Sedatives; Imipramine; Male; Nomifensine; Zimeldine	1981
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. The New England journal of medicine, 1982, Apr-22, Volume: 306, Issue:16 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Doxepin; Electrocardiography; Heart Diseases; Humans; Imipramine; Male; Middle Aged; Stroke Volume	1982
A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressives. International pharmacopsychiatry, 1982, Volume: 17, Issue:1 Topics: Adolescent; Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Dizziness; Doxepin; Female; Headache; Humans; Imipramine; Male; Middle Aged; Morpholines; Nausea; Viloxazine; Xerostomia	1982
Specific responses to imipramine and doxepin in psychoneurotic depressed patients with sleep disturbance. The Journal of clinical psychiatry, 1981, Volume: 42, Issue:7 Topics: Adult; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Imipramine; Male; Random Allocation; Sleep Wake Disorders	1981
Panic disorder with or without concomitant depression 5 years after treatment: a prospective follow-up. Journal of affective disorders, 1995, May-17, Volume: 34, Issue:2 Topics: Adult; Agoraphobia; Combined Modality Therapy; Comorbidity; Depressive Disorder; Doxepin; Female; Follow-Up Studies; Humans; Imipramine; Male; Panic Disorder; Prospective Studies; Psychotherapy	1995
Outcome of panic disorder with or without concomitant depression: A 2-year prospective follow-up study. The American journal of psychiatry, 1993, Volume: 150, Issue:12 Topics: Adult; Ambulatory Care; Antidepressive Agents; Combined Modality Therapy; Comorbidity; Depressive Disorder; Doxepin; Drug Therapy, Combination; Follow-Up Studies; Humans; Imipramine; Panic Disorder; Prospective Studies; Psychiatric Status Rating Scales; Psychotherapy; Treatment Outcome	1993
Fluctuation of symptoms and social functioning in panic disorder with or without concomitant depression. A 5-year prospective follow-up. Psychopathology, 1995, Volume: 28, Issue:5 Topics: Agoraphobia; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder; Doxepin; Follow-Up Studies; Humans; Imipramine; Interpersonal Relations; Panic Disorder; Personality Assessment; Prospective Studies; Psychotherapy; Social Adjustment; Treatment Outcome	1995
Predictors of outcome in panic disorder: a 5-year prospective follow-up study. Journal of affective disorders, 1996, Nov-25, Volume: 41, Issue:2 Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Doxepin; Female; Follow-Up Studies; Humans; Imipramine; Male; Middle Aged; Panic Disorder; Personality Assessment; Prospective Studies; Psychotherapy; Treatment Outcome	1996

Other Studies

86 other study(ies) available for imipramine and doxepin

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines. Journal of medicinal chemistry, 1984, Volume: 27, Issue:5 Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Body Temperature Regulation; Central Nervous System; Central Nervous System Agents; Imidazoles; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Relaxants, Central; Myocardium; Norepinephrine; Posture; Reserpine; Structure-Activity Relationship	1984
Imine analogues of tricyclic antidepressants. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Animals; Antidepressive Agents, Tricyclic; Female; Imines; Mice; Rats; Structure-Activity Relationship	1981
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16 Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Enzyme Inhibitors; Histamine H1 Antagonists; Micelles; Models, Biological; Norepinephrine; Rats; Receptors, Adrenergic, alpha-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Structure-Activity Relationship	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations	2002
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
Correlation of physicochemical properties with absorption and metabolism of some tricyclic drugs. The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:6 Topics: Absorption; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Doxepin; Imipramine; In Vitro Techniques; Male; Methylation; Phenothiazines; Promazine; Promethazine; Rats; Surface Tension	1978
Tricyclic antidepressants and histamine H1 receptors. Mayo Clinic proceedings, 1979, Volume: 54, Issue:10 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic	1979
Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats. Neuropharmacology, 1977, Volume: 16, Issue:4 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking Behavior; Fenclonine; Imipramine; Male; Methyltyrosines; Nortriptyline; Protriptyline; Rats; Water Deprivation	1977
Doxepin and imipramine: effect on catecholamine inhibition of ganglionic transmission. Life sciences, 1975, Jul-15, Volume: 17, Issue:2 Topics: Animals; Cats; Depression, Chemical; Dopamine; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Evoked Potentials; Female; Ganglia, Spinal; Imipramine; Male; Norepinephrine; Synapses; Synaptic Transmission	1975
Inhibition of rabbit monoamine oxidase by doxepin and related drugs. Life sciences, 1975, Apr-15, Volume: 16, Issue:8 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Chlorprothixene; Deamination; Depression, Chemical; Dibenzocycloheptenes; Doxepin; Humans; Hydrogen-Ion Concentration; Imipramine; Lung; Mitochondria; Monoamine Oxidase Inhibitors; Phenethylamines; Propylamines; Protriptyline; Rabbits; Serotonin	1975
Relationship between surface activity and toxicity to Chang liver cultures of tricyclic antidepressants. Pharmacology, 1979, Volume: 18, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cells, Cultured; Clomipramine; Doxepin; Glucuronidase; Humans; Imipramine; L-Lactate Dehydrogenase; Liver; Nortriptyline; Surface Tension	1979
Family practice management of depression: how to select tricyclic antidepressants. Southern medical journal, 1979, Volume: 72, Issue:6 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Doxepin; Family Practice; Humans; Imipramine	1979
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin. Clinical toxicology, 1979, Volume: 14, Issue:3 Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiovascular System; Dogs; Doxepin; Hypotension; Imipramine; Infusions, Parenteral	1979
Tricyclic antidepressant overdose: incidence of symptoms. JAMA, 1977, Jul-11, Volume: 238, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Electrocardiography; Heart; Humans; Imipramine; Nortriptyline	1977
Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II. The Journal of clinical psychiatry, 1979, Volume: 40, Issue:2 Topics: Antidepressive Agents, Tricyclic; Biotransformation; Clomipramine; Depression; Desipramine; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Doxepin; Drug Interactions; Humans; Imipramine; Maprotiline; Protriptyline	1979
High-performance liquid-chromatographic simultaneous determination of commonly used tricyclic antidepressants. Clinical chemistry, 1978, Volume: 24, Issue:11 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline	1978
Tricyclic antidepressant overdoses in adolescent patients. Pediatrics, 1977, Volume: 59, Issue:2 Topics: Adolescent; Affective Symptoms; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Imipramine; Male; Substance-Related Disorders; Suicide, Attempted	1977
Cardiac effects of different tricyclic antidepressant drugs. The British journal of psychiatry : the journal of mental science, 1976, Volume: 129 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bundle of His; Doxepin; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Imipramine; Nortriptyline; Substance-Related Disorders	1976
Assessment of cardiovascular side effects of therapeutic doses of tricyclic anti-depressant drugs. Australian and New Zealand journal of medicine, 1975, Volume: 5, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Pressure; Depression, Chemical; Doxepin; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Physical Exertion; Stimulation, Chemical	1975
Atypical endogenous depression. Diagnostic criteria. Acta psychiatrica Scandinavica. Supplementum, 1976, Volume: 267 Topics: Adult; Amitriptyline; Depression; Doxepin; Family; Female; Humans; Imipramine; Interpersonal Relations; Male; Middle Aged	1976
Evidence for feeding elicited through antihistaminergic effects of tricyclic antidepressants in the rat hypothalamus. Psychopharmacology, 1990, Volume: 101, Issue:4 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking; Eating; Histamine H1 Antagonists; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Methylhistidines; Microinjections; Rats; Rats, Inbred Strains; Zimeldine	1990
Prediction of steady-state plasma levels of doxepin and imipramine from single dose levels in depressed outpatients. Journal of psychiatry & neuroscience : JPN, 1991, Volume: 16, Issue:1 Topics: Adolescent; Adult; Ambulatory Care; Depressive Disorder; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Probability	1991
The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:1 Topics: Adenylyl Cyclase Inhibitors; Amitriptyline; Animals; Brain; Doxepin; Heart; Imipramine; In Vitro Techniques; Male; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1990
Post-mortem drug redistribution--a toxicological nightmare. Forensic science international, 1990, Volume: 45, Issue:3 Topics: Adult; Amobarbital; Barbiturates; Clomipramine; Doxepin; Female; Flurazepam; Humans; Imipramine; Male; Middle Aged; Pentobarbital; Postmortem Changes; Secobarbital; Suicide; Tissue Distribution	1990
[Drug treatment of nicotine dependence]. Medizinische Monatsschrift fur Pharmazeuten, 1990, Volume: 13, Issue:6 Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndrome	1990
Monitoring of the effects of antidepressant drugs in the freely moving rat by radioelectroencephalography (tele-stereo-EEG). Neuropsychobiology, 1988, Volume: 19, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Arousal; Brain; Dextroamphetamine; Doxepin; Electroencephalography; Haloperidol; Imipramine; Lysergic Acid Diethylamide; Male; Microcomputers; Nomifensine; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Telemetry	1988
The jitteriness syndrome in panic disorder patients treated with antidepressants. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:3 Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Doxepin; Fear; Female; Humans; Imipramine; Male; Panic; Patient Dropouts; Retrospective Studies; Sex Factors; Sleep Initiation and Maintenance Disorders	1988
Antidepressants: their uses in nonpsychiatric disorders of aging. Geriatrics, 1986, Volume: 41, Issue:10 Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depression; Doxepin; Female; Humans; Imipramine; Male; Narcolepsy; Nomifensine; Pain; Peptic Ulcer; Protriptyline; Sleep Apnea Syndromes; Syndrome; Trimipramine; Urinary Incontinence	1986
Cardiovascular effects of polycyclic antidepressants. Angiology, 1986, Volume: 37, Issue:10 Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression; Desipramine; Doxepin; Female; Heart; Humans; Imipramine; Male; Middle Aged	1986
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. Archives of general psychiatry, 1987, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Doxepin; Drug Administration Schedule; Drug Prescriptions; Drug Utilization; Female; Hospital Records; Hospitalization; Hospitals, General; Hospitals, Teaching; Humans; Imipramine; Male; Medicine; Middle Aged; Pain; Specialization	1987
Effect of fluoxetine on the electrocardiogram. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:3 Pt 2 Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block; Doxepin; Electrocardiography; Female; Fluoxetine; Heart; Heart Conduction System; Heart Rate; Humans; Imipramine; Male; Middle Aged; Propylamines; Retrospective Studies	1985
Treatment of acute posttraumatic stress disorder with tricyclic antidepressants. Southern medical journal, 1986, Volume: 79, Issue:2 Topics: Accidents, Occupational; Accidents, Traffic; Acute Disease; Adult; Antidepressive Agents, Tricyclic; Burns; Doxepin; Female; Follow-Up Studies; Humans; Imipramine; Male; Stress Disorders, Post-Traumatic	1986
PSOP for response to imipramine and doxepin. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:1 Topics: Blood Pressure; Doxepin; Humans; Hypotension, Orthostatic; Imipramine	1985
Effects of prenatal exposure to tricyclic antidepressants on adrenergic responses in progeny. Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Doxepin; Female; Gestational Age; Heart Rate; Hemodynamics; Imipramine; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sodium Nitrite; Sympathetic Nervous System	1985
A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors. The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:2 Topics: Amitriptyline; Animals; Blood Platelets; Carbon Radioisotopes; Chlorpromazine; Desipramine; Dibenzazepines; Doxepin; Imipramine; In Vitro Techniques; Kinetics; Models, Biological; Nortriptyline; Promazine; Rabbits; Serotonin; Synaptosomes; Temperature; Trifluoperazine; Triflupromazine	1974
The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction. Psychopharmacologia, 1974, Jan-14, Volume: 34, Issue:3 Topics: Amitriptyline; Amphetamine; Animals; Biogenic Amines; Catecholamines; Chlorine; Chlorpheniramine; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Female; Haloperidol; Imipramine; Methyltyrosines; Motor Activity; Rats; Receptors, Cholinergic; Serotonin Antagonists; Spiro Compounds; Time Factors	1974
Comparison of tricyclic antidepressants in rabbits: antinociception and potentiation of the noradrenaline pressor responses. Psychopharmacologia, 1974, Feb-27, Volume: 35, Issue:3 Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Aorta; Blood Pressure; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Imipramine; In Vitro Techniques; Iprindole; Lithium; Morphine; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Succinimides; Time Factors	1974
[Effect of antidepressive drugs and histamine H1 receptor blockaders on histamine level in rat brain]. Folia medica Cracoviensia, 1984, Volume: 25, Issue:3-4 Topics: Animals; Brain Chemistry; Doxepin; Histamine; Histamine Release; Imipramine; In Vitro Techniques; Male; Promethazine; Rats; Rats, Inbred Strains; Time Factors; Tripelennamine	1984
Suppression of histamine-induced adrenocorticotropic hormone release by antihistamines and antidepressants. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3 Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents; Desipramine; Diazepam; Doxepin; Histamine; Histamine H1 Antagonists; Imipramine; Iprindole; Male; Mianserin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Histamine; Stimulation, Chemical	1982
Drug-specific EEG frequency spectra and their time courses produced in the cat by antidepressants and a benzodiazepine. Electroencephalography and clinical neurophysiology, 1981, Volume: 52, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cats; Desipramine; Diazepam; Dose-Response Relationship, Drug; Doxepin; Electroencephalography; Female; Imipramine	1981
Monosymptomatic hypochondriasis treated with tricyclic antidepressants. The American journal of psychiatry, 1984, Volume: 141, Issue:12 Topics: Adult; Delusions; Doxepin; Female; Humans; Hypochondriasis; Imipramine; Male; Somatoform Disorders	1984
A clinical report of thymoleptic-responsive atypical paranoid psychoses. The American journal of psychiatry, 1983, Volume: 140, Issue:9 Topics: Adult; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Delusions; Diagnosis, Differential; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Paranoid Disorders; Phenelzine; Psychotic Disorders	1983
Liquid chromatographic separation of antidepressant drugs: I. Tricyclics. Therapeutic drug monitoring, 1983, Volume: 5, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Promazine; Protriptyline	1983
Action of antidepressants, stimulants and depressants in the transition from a fixed ratio to a fixed interval schedule of reinforcement. Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:1 Topics: Amitriptyline; Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Operant; Diazepam; Doxepin; Imipramine; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule	1983
The dexamethasone suppression test in depressive illness: clinical correlates. Psychoneuroendocrinology, 1982, Volume: 7, Issue:4 Topics: Depressive Disorder; Desipramine; Dexamethasone; Diagnosis, Differential; Double-Blind Method; Doxepin; Electroconvulsive Therapy; Female; Humans; Hydrocortisone; Imipramine; Male; Mianserin; Middle Aged; Nortriptyline; Phenelzine; Psychiatric Status Rating Scales; Selegiline	1982
Tricyclic antidepressants and supine, standing, and exercise plasma norepinephrine levels. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:6 Topics: Adult; Amitriptyline; Blood Pressure; Depressive Disorder; Doxepin; Epinephrine; Female; Heart Rate; Humans; Imipramine; Male; Middle Aged; Norepinephrine; Physical Exertion; Posture	1983
The use of antidepressants with methadone in depressed maintenance patients. Annals of the New York Academy of Sciences, 1982, Volume: 398 Topics: Depressive Disorder; Doxepin; Female; Humans; Imipramine; Male; Methadone; Middle Aged; Opioid-Related Disorders	1982
TCA-induced mania: differences between switchers and nonswitchers. Biological psychiatry, 1982, Volume: 17, Issue:2 Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Protriptyline	1982
Resin hemoperfusion in the treatment of tricyclic antidepressant overdose. Artificial organs, 1982, Volume: 6, Issue:2 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bromazepam; Doxepin; Female; Hemoperfusion; Humans; Imipramine; Ion Exchange Resins; Polystyrenes; Polyvinyls; Renal Dialysis	1982
Treating geriatric depression: a 26-week interim analysis. Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:11 Topics: Antidepressive Agents, Tricyclic; Behavior Therapy; Cognition; Depressive Disorder; Double-Blind Method; Doxepin; Humans; Imipramine; Middle Aged; Psychotherapy, Group	1982
The relationship of therapeutic response to antidepressant plasma levels: an update. The Journal of clinical psychiatry, 1982, Volume: 43, Issue:11 Pt 2 Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Biological Availability; Depressive Disorder; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Patient Compliance; Protriptyline	1982
Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin. Clinica chimica acta; international journal of clinical chemistry, 1981, Apr-09, Volume: 111, Issue:2-3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline	1981
Liquid-chromatographic analysis for common tricyclic antidepressant drugs and their metabolites in serum or plasma with the technicon "FAST-LC" system. Clinical chemistry, 1981, Volume: 27, Issue:6 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Protriptyline	1981
The depression-pain syndrome and its response to antidepressants. Psychosomatics, 1981, Volume: 22, Issue:7 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Pain; Syndrome	1981
Clinical and biological aspects of depression in the elderly. Proceedings of the annual meeting of the American Psychopathological Association, 1980, Volume: 69 Topics: Aged; Dementia; Depression; Doxepin; Humans; Imipramine; Methylphenidate; Middle Aged; Trazodone	1980
Electrophysiologic effects of imipramine and doxepin on normal and depressed cardiac Purkinje fibers. The American journal of cardiology, 1980, Volume: 46, Issue:4 Topics: Action Potentials; Animals; Dogs; Doxepin; Electrophysiology; Heart Conduction System; Imipramine; Membrane Potentials; Purkinje Fibers	1980
Behavioral and pharmacological treatment of obsessive-compulsive disorders. The Journal of nervous and mental disease, 1980, Volume: 168, Issue:11 Topics: Adolescent; Adult; Behavior Therapy; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Imipramine; Implosive Therapy; Male; Obsessive-Compulsive Disorder	1980
Correct titration of non-drugs and some other methodological issues. Neuropsychobiology, 1994, Volume: 30, Issue:1 Topics: Administration, Oral; Amitriptyline; Anxiety Disorders; Benperidol; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Doxepin; Drug Administration Schedule; Flupenthixol; Fluspirilene; Haloperidol; Humans; Imipramine; Injections, Intramuscular; Promethazine; Psychotropic Drugs; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Schizophrenic Psychology; Single-Blind Method	1994
Tricyclic antidepressants change plasma histamine kinetics after its secretion induced by compound 48/80 in the rat. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Doxepin; Female; Histamine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats	1998
On-line capillary electrophoresis-electrospray ionization mass spectrometry using a polymerized anionic surfactant. Electrophoresis, 1998, Volume: 19, Issue:12 Topics: Adrenergic beta-Antagonists; Alprenolol; Amitriptyline; Anions; Antidepressive Agents, Tricyclic; Cations; Doxepin; Electrophoresis, Capillary; Imipramine; Mass Spectrometry; Polymers; Propranolol; Sulfates; Surface-Active Agents; Undecylenic Acids	1998
Effect of psychotropic drugs on taste responses in young and elderly persons. Annals of the New York Academy of Sciences, 1998, Nov-30, Volume: 855 Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Psychotropic Drugs; Taste; Trifluoperazine	1998
Ring flexibility within tricyclic antidepressant drugs. Journal of pharmaceutical sciences, 2001, Volume: 90, Issue:6 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Carbon Radioisotopes; Dothiepin; Doxepin; Imipramine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pliability; Temperature	2001
[Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2001, Volume: 11, Issue:66 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autopsy; Binding Sites; Brain; Clomipramine; Depressive Disorder; Doxepin; Glutathione Transferase; Humans; Imipramine	2001
Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants. Neuropharmacology, 2003, Volume: 45, Issue:7 Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cell Membrane; Doxepin; Excitatory Amino Acid Antagonists; Humans; Imipramine; In Vitro Techniques; Kidney; Kinetics; Membrane Potentials; Mice; Nicotinic Antagonists; Patch-Clamp Techniques; Phencyclidine; Receptors, Nicotinic; Torpedo	2003
Are selective serotonin re-uptake inhibitors associated with an increased risk of self-harm by antidepressant overdose? European journal of clinical pharmacology, 2004, Volume: 60, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Citalopram; Cyclohexanols; Doxepin; Drug Overdose; Drug Prescriptions; Emergency Service, Hospital; Female; Fluoxetine; Humans; Imipramine; Information Services; Male; Mianserin; Mirtazapine; Paroxetine; Patient Admission; Patient Readmission; Poison Control Centers; Retrospective Studies; Risk Assessment; Scotland; Selective Serotonin Reuptake Inhibitors; Self-Injurious Behavior; Sertraline; Trazodone; Venlafaxine Hydrochloride	2004
Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta biochimica Polonica, 2004, Volume: 51, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Doxepin; Glutathione S-Transferase pi; Humans; Imipramine; Isoenzymes; Kinetics; Oxidation-Reduction	2004
Excess fatality from desipramine in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:1 Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; Nortriptyline; Prevalence; Substance-Related Disorders	2006
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. European journal of anaesthesiology, 2007, Volume: 24, Issue:8 Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Apoptosis; Cell Count; Cell Culture Techniques; Dose-Response Relationship, Drug; Doxepin; Electric Impedance; Female; Ganglia, Spinal; Imipramine; Pain; Rats; Rats, Sprague-Dawley; Sodium Channels; Time Factors	2007
Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids. Journal of separation science, 2007, Volume: 30, Issue:15 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Clomipramine; Doxepin; Drug Monitoring; Humans; Imipramine; Models, Chemical; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry; Time Factors; Urinalysis	2007
Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states. European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1 Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cell Line; Cysteine; Dose-Response Relationship, Drug; Doxepin; Humans; Imipramine; Membrane Potentials; Mice; Mutation; Nicotinic Antagonists; Protein Conformation; Protein Structure, Tertiary; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Transfection	2008
Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation. Colloids and surfaces. B, Biointerfaces, 2013, Mar-01, Volume: 103 Topics: Administration, Cutaneous; Analgesics; Animals; Area Under Curve; Chemistry, Pharmaceutical; Doxepin; Drug Delivery Systems; Emulsions; Evaluation Studies as Topic; Humans; Hyperalgesia; Imipramine; In Vitro Techniques; Male; Nanoparticles; Oils; Permeability; Phase Transition; Rats; Rats, Sprague-Dawley; Skin Absorption; Water	2013
Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes. BMC anesthesiology, 2015, Aug-08, Volume: 15 Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Doxepin; Excitatory Amino Acid Transporter 3; Female; Fluoxetine; Glutamic Acid; Imipramine; Oocytes; Protein Kinase C; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Xenopus laevis	2015
Tricyclic antidepressants inhibit Candida albicans growth and biofilm formation. International journal of antimicrobial agents, 2018, Volume: 52, Issue:4 Topics: Amphotericin B; Antidepressive Agents, Tricyclic; Antifungal Agents; Biofilms; Candida; Candida albicans; Candida glabrata; Doxepin; Drug Repositioning; Drug Synergism; Fungal Proteins; Gene Expression Regulation, Fungal; Humans; Hyphae; Imipramine; Inactivation, Metabolic; Microsomes, Liver; Nortriptyline; Plankton	2018
Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine. Analytica chimica acta, 2020, Apr-15, Volume: 1106 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Doxepin; Humans; Imipramine; Liquid Phase Microextraction; Macromolecular Substances; Mass Spectrometry; Molecular Structure; Nortriptyline; Paper	2020