imipramine has been researched along with desipramine in 1184 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 814 (68.75) | 18.7374 |
| 1990's | 194 (16.39) | 18.2507 |
| 2000's | 103 (8.70) | 29.6817 |
| 2010's | 63 (5.32) | 24.3611 |
| 2020's | 10 (0.84) | 2.80 |
| Authors | Studies |
|---|---|
| Crichlow, CA; Geyer, HM; Klioze, SS; Kruse, H; Martin, LL; Worm, M | 1 |
| Bauer, VJ; Geyer, HM; Klioze, SS | 1 |
| Andree, T; Bicksler, J; Butch, J; Fletcher, H; Husbands, GE; James, MN; Moyer, JA; Muth, EA; Stack, G; Yardley, JP | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Costanzo, MJ; Gardocki, JF; Maryanoff, BE; McComsey, DF; Nortey, SO; Schneider, CR; Setler, PE; Shank, RP | 1 |
| Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM | 1 |
| Bonnaud, B; Briley, M; Cousse, H; Couzinier, JP; Fauran, F; Mouzin, G; Stenger, A | 1 |
| Marx, M; Wallach, MB; Weinhardt, K | 1 |
| Ross, BS; Wiley, RA | 1 |
| Chiang, GH; Unger, SH | 1 |
| Högberg, T; Renyi, AL; Ross, SB; Ulff, B | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Medina-Hernández, MJ; Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X | 1 |
| Glennon, RA; Roth, BL; Runyon, SP; Savage, JE; Taroua, M; Westkaemper, RB | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Erez, M; Keinan, E; Levy, O; Varon, D | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Keserü, GM | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Ikeda, K; Kobayashi, T; Washiyama, K | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Adkins, S; Duval, RA; Foster, JD; Hauck-Newman, A; Kulkarni, SS; Lever, JR; Parnas, ML; Sakrikar, DS; Vaughan, RA | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Goetz, RM; Karpowich, NK; Law, CJ; Reith, ME; Wang, DN; Zhen, J; Zhou, Z | 1 |
| Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Buck, LB; Petrascheck, M; Ye, X | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Kenny, PW; Toulmin, A; Wood, JM | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Bleich, S; Kornhuber, J; Rupprecht, R; Terfloth, L; Wiltfang, J | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Huang, K; Juniku, R; White, JD; Wong, DT; Yang, J | 1 |
| Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Sen, S; Sinha, N | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM | 1 |
| Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Bright, SA; Brinkø, A; Jensen, HH; Larsen, MT; Sinning, S; Williams, DC | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Choi, K; Moon, B; Park, JE; Roh, EJ; Sim, T; Song, C | 1 |
| Alix, K; Dukat, M; Khatri, S; Schulte, MK; Worsham, J | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E | 1 |
| Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW | 1 |
| Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW | 1 |
| Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S | 1 |
| Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW | 1 |
| Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Bibak, N; Blaess, M; Bonaterra, GA; Claus, RA; Deigner, HP; Kinscherf, R; Kohl, M; Laufer, S | 1 |
| Dolezal, R; Hepnarova, V; Hrabinova, M; Jost, P; Jun, D; Kaping, D; Kerhartova, M; Korabecny, J; Kuca, K; Kucera, T; Matouskova, L; Mezeiova, E; Muckova, L; Nepovimova, E; Pham, NL; Soukup, O; Spilovska, K; Staud, F; Vykoukalova, N | 1 |
| Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME | 1 |
| Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Cardoso, FC; Duggan, PJ; Kuiper, MJ; Lewis, RJ; Schmit, M; Tuck, KL | 1 |
| Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Modestin, J; Petrin, A | 1 |
| Nagy, A | 2 |
| Mason, MF | 1 |
| Adolphe, AB; Dorsey, ER; Napoliello, MJ | 1 |
| Maas, JW | 2 |
| Hollister, LE | 3 |
| Richelson, E | 1 |
| Løvstad, RA | 1 |
| Cohen, D; Weinstock, M | 1 |
| Fromm, GH; Glass, JD | 1 |
| Huh, K; Iwata, H; Yamamoto, I | 1 |
| Levine, RM; Maickel, RP; Spaulding, JH; Zabik, JE | 1 |
| Baba, A; Iwata, H; Matsuda, T; Terashita, Z | 1 |
| Hollander, CS; Tai, HH | 1 |
| Carlsson, I; Lagerström, PO; Persson, BA | 1 |
| Borsy, J; Király, I; Korányi, L; Lissák, K; Tamásy, V | 1 |
| Franz, DN; Sangdee, C | 1 |
| Bickel, MH | 6 |
| Millichap, JG | 1 |
| Lippmann, W; Puglsey, TA | 1 |
| Ueki, S; Yamamoto, T | 1 |
| Borg, S; d'Elia, G; Forshell, GP; Lundin, G; Raotma, H; Román, G; Siwers, B | 1 |
| Davidson, JR; Kurland, AA; McLeod, MN; White, HL | 1 |
| Dorrity, F; Jobson, K; Linnoila, M | 1 |
| Grünes, JU; Knorr, W; Kühne, GE; Perina, L; Richter, H; Rommel, U; Sorger, R; Stöck, H; Waldow, N | 1 |
| Claeys, MM; Goodwin, FK; Markey, SP; Muscettola, G; Potter, WZ | 1 |
| Kopin, IJ; Lake, CR; Mikkelsen, EJ; Rapoport, JL; Zavadil, AP | 1 |
| Bech, P; Christiansen, J; Dencker, SJ; Gram, LF; Ibsen, I; Jacobsen, O; Krautwald, O; Nagy, A; Ortmann, J; Petersen, GO; Reisby, N; Sondergaard, I | 1 |
| Korf, J; Meisch, JJ; van Wijk, M | 1 |
| Lehmann, WD; Schulten, HR | 1 |
| Orsulak, PJ; Sovner, R | 1 |
| Eiden, LE; Grunewald, GL; Reitz, TJ; Ruth, JA; Rutledge, CO; Vollmer, S | 1 |
| Briley, M; Langer, SZ; Raisman, R | 1 |
| Amsterdam, JD; Brunswick, DJ; Mendels, J; Stern, SL | 1 |
| Kelder, D; Ross, SB | 2 |
| Brunswick, D; Garbutt, J; Jolliff, L; Jonnalagadda, MR; Malekpour, B; Podolak, R; Prange, A; Wilson, I | 1 |
| Jusko, WJ; Sutfin, TA | 1 |
| Gualtieri, CT; Jobson, K; Linnoila, M; Staye, J | 1 |
| Alkalay, D; Carlsen, S; Volk, J | 1 |
| Calil, HM; Goodwin, FK; Manian, AA; Potter, WZ; Zavadil, AP | 1 |
| Bigger, JT; Giardina, EG; Glassman, AH; Kantor, SJ; Perel, JM | 1 |
| Bradley, PB; Neal, H | 1 |
| Barrow, CG; Reece, PA; Zacest, R | 1 |
| Chambers, WJ; Lupatkin, W; Perel, JM; Puig-Antich, J; Shea, C; Stiller, RL; Tabrizi, MA | 1 |
| Orsulak, PJ; Schildkraut, JJ | 1 |
| Appelbaum, PS; Orsulak, PJ; Schildkraut, JJ; Vasile, RG | 1 |
| Biggs, JT; Petit, JM; Spiker, DG; Ziegler, VE | 1 |
| Hansen, T; Nagy, A | 1 |
| Huey, LY; Janowsky, DS; Risch, SC | 1 |
| Braestrup, C; Nielsen, M | 1 |
| Bhanji, S; Lader, M | 1 |
| Howarth, AT | 1 |
| Adams, RF; Schmidt, GJ; Vandemark, FL | 1 |
| Brunswick, DJ; Mendels, J; Needelman, B | 1 |
| Davis, CM; Fenimore, DC; Meyer, CJ | 1 |
| Biggs, JT; Meyer, DA; Preskorn, SH; Rosen, SH; Ziegler, VE | 1 |
| Mikkelsen, EJ; Rapoport, JL; Zavadil, AP | 1 |
| Bailey, DN; Jatlow, PI; Langou, RA; Van Dyke, C | 1 |
| Lohmann, HJ; Miles, DG; Proelss, HF | 1 |
| McKim, HR; Reed, K | 1 |
| Bonora, A; Borea, PA | 1 |
| Gram, LF | 2 |
| Glassman, AH; Perel, JM; Stiller, RL | 1 |
| Davis, JM; Javaid, JI; Perel, JM | 1 |
| Bech, P; Christiansen, J; Dencker, SJ; Gram, LF; Ibsen, I; Nagy, A; Petersen, GO; Reisby, N | 1 |
| Blosfeld, G; Fabiano, B; Knorr, W; Kühne, GE; Perina, L; Richter, H; Rommel, B; Sorger, R; Stöck, H; Waldow, N | 1 |
| Biggs, JT; Petit, JM | 1 |
| Fleiss, JL; Glassman, AH; Kantor, SJ; Perel, JM; Shostak, M | 1 |
| Aghamanian, GK; Davis, M; Gallager, DW | 1 |
| Buckley, JP; Jandhyala, BS; Manian, AA; Perel, JM; Steenberg, ML | 1 |
| Cooper, TB; Friedman, MJ; Green, R; Ives, JO; Nies, A; Ravaris, CL; Robinson, DS | 1 |
| Olsson, SO; Petersen, EN; Squires, RF | 1 |
| Claeys, M; Maenhaut, W; Markey, SP | 1 |
| Ghosh, PK; Hrdina, PD | 1 |
| Curran, NM; Lovering, EG; McErlane, KM | 1 |
| Oliver, JS; Smith, H | 1 |
| Davis, CM; Fenimore, DC; Hsu, F; Meyer, CJ; Zlatkis, A | 1 |
| Brookman, S; Kourounakis, P | 2 |
| Lagerström, PO; Persson, BA | 1 |
| Campbell, IC | 1 |
| Olling, M; Rauws, AG | 1 |
| Almeida, M; Gershon, S; Sathananthan, GL; Spector, N; Spector, S | 1 |
| Breyer, U; Villumsen, K | 1 |
| Lippman, W; Pugsley, TA | 1 |
| Bailey, DN; Jatlow, PI | 1 |
| Kling, MA; Orsulak, PJ; Reigle, TG; Roffman, M; Schatzberg, AF; Schildkraut, JJ | 1 |
| Andrée, G; Meiser, H; Schmitt, W | 1 |
| Claeys, M; Markey, SP; Muscettola, G | 1 |
| Detaevernier, MR; Dryon, L; Massart, DL | 1 |
| Glassman, AH; Kantor, SJ; Mendlewicz, J; Perel, JM; Shostak, M | 1 |
| Klimek, V; Maj, J; Rawlów, A; Sarnek, J | 1 |
| Eplov, L; Nielsen, M; Scheel-Krüger, J | 1 |
| Johansson, R; Nagy, A | 1 |
| Hurwic, MJ; Kanzler, MB; Perel, JM | 1 |
| Henry, BW; Overall, JE; Woodward, JA | 1 |
| Hargreaves, T; Piper, RF | 1 |
| Mack, G; Mandel, P; Treska-Ciesielski, J; Zwiller, J | 1 |
| Bevan, P; Bradshaw, CM; Szabadi, E | 1 |
| Christiansen, J; Gram, LF | 2 |
| Bossa, R; Dubini, F; Galatulas, I; Tofanetti, O | 1 |
| van Spanning, HW; van Zwieten, PA | 2 |
| Biamino, G; Fenner, H; Lohmann, RW; Neye, J; Ramdohr, B; Schüren, KP | 1 |
| Huang, CL; Liu, SJ; Waters, IW | 1 |
| Boissier, J; Buschsenschultz, E; Oliver-Marti n, R; Pichot, P | 1 |
| Keup, W; Roubein, IF | 1 |
| Schildkraut, JJ | 1 |
| Belvedere, G; Burti, L; Frigerio, A; Pantarotto, C | 1 |
| Davila, D; Davila, T | 1 |
| Krupp, P; Wesp, M | 1 |
| Renyi, AL; Ross, SB | 4 |
| Oksenkrug, GF | 1 |
| Nomura, Y; segawa, T; Tanaka, Y | 1 |
| Grewal, RS; Kaul, CL | 1 |
| Carvalho Lemos, JM; López, M; Silva, OA | 1 |
| Allen, D; Cooper, TB; Simpson, GM | 1 |
| Bobkiewicz, T; Chodera, A; Drutel, B; Szpunar, K | 1 |
| Biamino, G; Neye, G; Neye, J; Nöring, J | 1 |
| Bridges, JW; Dent, JG; Johnson, P | 1 |
| McIlwain, H; Pull, I | 1 |
| Dencker, H; Dencker, SJ; Green, A; Nagy, A | 1 |
| Kunihara, M; Nakano, M; Ohyama, M | 1 |
| Briley, M; Moret, C | 1 |
| Daniel, W; Melzacka, M | 2 |
| Avenoso, A; Campo, GM; Caputi, AP; Pollicino, MA; Spina, E | 1 |
| Beck-Nielsen, H; Brøsen, K; Gram, LF; Grodum, E; Sindrup, SH; Skjold, T; Tuxen, C | 1 |
| Holt, KG | 1 |
| Domínguez-Gil, A; Fernández de Gatta, MM; García, MJ; Tamayo, M | 2 |
| Bech, P; Clemmesen, L; Klysner, R; Lauritzen, L; Loldrup, D; Lunde, M; Schaumburg, E; Waarst, S | 1 |
| Bergstrom, RF; Lemberger, L; Peyton, AL | 1 |
| Molina, VA; Murua, VS | 1 |
| Balant, LP; Balant-Gorgia, AE; Gay, M; Gex-Fabry, M | 1 |
| Fast, GA; Preskorn, SH | 1 |
| Field, SL; Murray, M | 1 |
| Baker, GB; Greenshaw, AJ; Martin, IL; McKenna, KF; McManus, DJ | 1 |
| Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR | 1 |
| Overstreet, DH; Pucilowski, O; Schiller, GD; Wienicke, C | 1 |
| Chessler, RK; Elias, S; Patel, YJ; Scherl, ND; Zingler, BM | 1 |
| Greenshaw, AJ; McManus, DJ; Mousseau, DD; Paetsch, PR; Wishart, TB | 1 |
| Melzacka, M; Nocon, H | 1 |
| Danek, L; Daniel, W; Janczar, L; Melzacka, M; Nocon, H | 1 |
| Kiryon, C; Miki, A; Nakayama, T; Ohsawa, K; Tanabe, K | 1 |
| Boczkowski, JA; Levine, EG | 1 |
| Kapur, S; Mann, JJ | 1 |
| Naruse, R; Nomura, S; Okada, H; Yamaoka, K | 1 |
| Ambrogi, F; Cassano, GB; Marazziti, D; Rotondo, A | 1 |
| Holle, L; Lemmer, B | 1 |
| Barden, N; Peiffer, A; Veilleux, S | 1 |
| Czuczwar, SJ; Gustaw, J; Kleinrok, Z | 1 |
| Foglia, JP; Perel, JM; Sorisio, D | 1 |
| Bures, P; Fuksová, K; Krulík, R; Sikora, J | 1 |
| Bures, P; Havránek, M; Krulík, R; Simůnková, D | 1 |
| Goromaru, T; Hashimoto, K | 1 |
| Healy, DT; Horton, RW; Johnson, AL; Lawrence, K; Paykel, ES; Theodorou, AE; White, W; Whitehouse, AM; Wilton-Cox, H | 1 |
| Kestenbaum, T; Sieg, K; Stevenson, EK; Warnock, JK; Willsie, D | 1 |
| Imamura, Y; Otagiri, M; Uchiyama, S | 1 |
| DeRubeis, RJ; Evans, MD; Garvey, M; Hollon, SD; Tuason, VB | 1 |
| Carrón, R; Delpón, E; Pérez-Vizcaino, F; Tamargo, J | 1 |
| Graf, U; van Schaik, N | 1 |
| Cai, B; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H | 1 |
| Dewan, M; Masand, P | 1 |
| Adebodun, F; Chung, J; Le, HB; Montez, B; Oldfield, E; Park, KD; Phillips, B | 1 |
| Tingelstad, JB | 1 |
| Ferraino, R; Fritz, PM; Hamel, LT; Haubrich, DR; Luttinger, D; Perrone, MH | 1 |
| Fujimoto, K; Ookuma, K; Sakata, T | 1 |
| Brøsen, K; Gram, LF; Hallas, J; Skjelbo, E | 1 |
| Bartels, MG; Mitchell, J; Stamm, SJ; Varley, CK | 1 |
| Borsini, F; D'Aranno, V; Lecci, A; Mancinelli, A; Meli, A; Stasi, MA | 1 |
| Brøsen, K; Gram, LF; Kragh-Sørensen, P | 1 |
| Moeller, FG; Rausch, JL | 1 |
| Breese, GR; Duncan, GE; Fassberg, JB; Paul, IA; Powell, KR; Stumpf, WE | 1 |
| Hegenscheid, B; Presber, HW | 1 |
| Bradshaw, CM; Shah, K; Szabadi, E | 1 |
| Ackerman, SH; Banay-Schwartz, M; Russ, MJ; Shindledecker, RD; Smith, GP | 1 |
| Brøsen, K; Eshøj, O; Gram, LF; Mogensen, EF; Sindrup, SH | 1 |
| Pollock, BG; Sallee, FR | 1 |
| Joffe, RT; Singer, W | 1 |
| Baraldo, M; Benetello, P; Furlanut, M; Zara, G | 1 |
| Daniel, W; Netter, KJ | 1 |
| Babb, SV; Dunlop, SR; Hoffmann, MA | 1 |
| Brown, CS; Cold, JA; Froemming, JH; Jabbour, JT; Self, TH; Wells, BG | 1 |
| Domínguez-Gil, A; Fernández de Gatta, MM; Galindo, P; García, MJ; Gutierrez, J; Rey, F; Tamayo, M | 1 |
| Lothman, EW; Stringer, JL | 1 |
| Chatelain, F; Martin, P; Massol, J; Puech, AJ | 1 |
| Higashi, Y; Murakami, T; Nishiura, A; Toyoda, T; Yata, N | 1 |
| Abalan, F; Brachet-Liermain, A; Hecquet, D; Rigal, F; Schweiger, K; Sousselier, M | 1 |
| Brøsen, K; Gram, LF; Sindrup, SH | 1 |
| Cooper, T; Dell, RB; Hein, K; Puig-Antich, J; Ramakrishnan, R | 1 |
| Jarrett, DB; Kupfer, DJ; Miewald, JM | 1 |
| Chiba, M; Fujita, S; Suzuki, T | 2 |
| Braun, W; Grandt, R; Hitzenberger, G; Schmid, R | 1 |
| Baba, S; Sasaki, Y; Shinohara, Y | 1 |
| Beck-Nielsen, H; Frøland, A; Gram, LF; Sindrup, SH; Skjold, T | 1 |
| Kitteringham, NR; Park, BK; Riley, RJ; Roberts, P | 1 |
| Boix, F; Escorihuela, RM; Fernández-Teruel, A; Tobeña, A | 1 |
| Lavoie, PA; Tiberi, M | 1 |
| Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI | 1 |
| Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
| Kobayashi, A; Nakazawa, K; Sugita, S; Suzuki, S; Yoshida, T | 3 |
| Borsini, F; Giuliani, S; Gragnani, L; Lecci, A; Maggi, CA; Meli, A; Meli, P | 1 |
| Hrdina, PD | 3 |
| Belon, JP; Martin, P; Massol, J; Puech, AJ; Soubrié, P | 1 |
| De Souza, EB; Grigoriadis, DE; Pearsall, D | 1 |
| Arora, RC; Meltzer, HY | 1 |
| Lloyd, KG; Martin, P; Massol, J; Pichat, P; Puech, AJ; Soubrié, P | 1 |
| Boix, F; Corda, MG; Escorihuela, RM; Fernández Teruel, A; Tobeña, A | 1 |
| Barkai, AI; Murthy, LR | 1 |
| Amador, D; Domínguez-Gil Hurlé, A; Fernández de Gatta, MM; García, MJ; Gutiérrez, JR; Rey, F; Tamayo, M | 1 |
| Perel, JM; Somogyi, GT | 1 |
| Garland, J; Tribble, J; Weinhouse, E; Wendelberger, K | 1 |
| Eckert, ED; Hatsukami, D; Mitchell, JE; Pomeroy, C; Pyle, RL; Zimmerman, R | 1 |
| Albin, H; Demotes-Mainard, F; Fança, X; Rigal, J; Vinçon, G | 1 |
| Richens, A; Tedstone, JE; Tsanaclis, LM; Williams, J; Wilson, JF | 1 |
| Domínguez-Gil, A; Fernandez de Gatta, MM; Garcia, MJ; Montojo, C; Ramón Gutierrez, J; Rey, F; Tamayo, M | 1 |
| Bupp, SJ; Preskorn, SH; Weller, EB; Weller, RA | 1 |
| Kahn, D; Opler, LA; Silver, JM | 1 |
| Danti, S; Fermanian, J; Frances, H | 1 |
| Anderson, P; George, DT; Linnoila, M; Nutt, DJ | 1 |
| Bonadies, J; Hardin, NJ; Morrow, PL | 1 |
| Brøsen, K; Gram, LF | 2 |
| Brumback, RA; Carlson, KM; Gascon, GG; Konewko, PJ; Patterson, BD; Staton, RD; Wilson, H | 1 |
| Barbaccia, ML; Costa, E; Szekely, AM | 1 |
| Ohi, K; Shimoda, K; Takahashi, K; Takahashi, S; Tsujimoto, T; Yamada, N | 1 |
| Cooper, MM; Day, JS; Sethy, VH | 1 |
| Chiu, A; Li, PP; Sibony, D; Warsh, JJ | 1 |
| Chatelain, F; Martin, P; Massol, J; Puech, AJ; Soubrié, P | 1 |
| Anami, K; Setoguchi, M; Yamamoto, Y | 1 |
| Ballenger, JC; Gold, PW; Post, RM; Rubinow, DR | 1 |
| Hanano, M; Iga, T; Lin, TH; Sawada, Y; Sugiyama, Y | 2 |
| Asakura, M; Tsukamoto, T | 1 |
| Cardamone, J; Cook, PE; Dermer, SW | 1 |
| Cash, R; Danti, S; Frances, H; Raisman, R; Renwart, N; Simon, P | 1 |
| Feet, PO; Holm, V; Larsen, S; Liden, A; Lillevold, PE; Robak, OH | 1 |
| Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K | 1 |
| Balkovetz, DF; Ganapathy, V; Leibach, FH; Mahesh, VB; Tiruppathi, C | 1 |
| Kim, SS; Reith, ME | 1 |
| Balon, R; Berchou, R; Pohl, R; Yeragani, VK | 1 |
| Bäckström, IT; Marcusson, J; Ross, SB | 1 |
| Dhawan, KN; Gulati, A; Gupta, GP; Nath, C | 1 |
| Abel, MS; Clody, DE; Meyerson, LR; Wennogle, LP | 1 |
| Brunswick, DJ; Conway, PG | 1 |
| Langer, SZ; Schoemaker, H; Segonzac, A; Tateishi, T | 1 |
| Czyrak, A; Klimek, V; Mogilnicka, E; Nowak, G | 1 |
| Biegon, A | 2 |
| Cooper, T; Friedman, E; Yocca, F | 1 |
| Anderson, B; Severson, JA | 1 |
| Baran, L; Przegaliñski, E; Rokosz-Pelc, A; Vetulani, J | 1 |
| Dorey, RC; Preskorn, SH; Widener, PK | 1 |
| Feet, PO; Larsen, S; Lillevold, PE; Robak, OH | 1 |
| Balon, R; Berchou, R; Ortiz, A; Pohl, R; Rainey, JM; Yeragani, VK | 1 |
| Fukuda, S; Lee, TJ; Su, C | 1 |
| Bovier, P; Gaillard, JM; Tissot, R; Widmer, J | 1 |
| Anwyl, R; Rowan, MJ | 2 |
| Bowden, CL; Brunswick, D; Carl, J; Frazer, A; Hanin, I; Kocsis, JH; Koslow, SH; Robins, E | 1 |
| Czartorysky, B; Harding, J | 1 |
| Clary, C; Dever, A; Schweizer, E | 1 |
| Joffe, RT; Regan, JJ | 1 |
| Farská, I; Krulík, R; Slíva, D | 2 |
| Baba, S; Horie, M; Sasaki, Y | 1 |
| Bonea, M; Da Rold, A; Maffei Faccioli, A; Manfè, AZ; Terranova, O | 1 |
| Marcusson, J; Tiger, G | 1 |
| Bäckström, IT; Marcusson, JO | 1 |
| Adan, F; Casey, E; Cooper, TB; Lee, A; Mandeli, J; Siris, SG | 1 |
| Balon, R; Lycaki, H; Pohl, R; Yeragani, VK | 1 |
| Jusko, WJ; Molnar, G; Perini, GI; Sutfin, TA | 1 |
| Barnhill, JG; Ciraulo, DA; Jaffe, JH | 1 |
| Baumann, P; Cuendet, C; Eap, CB | 1 |
| Baba, S; Sasaki, Y | 1 |
| Franklin, M; Middleton, H; Nutt, D | 1 |
| Friedman, H; Greenblatt, DJ; Harmatz, JS; Kennedy, JS; Scavone, JM; Shader, RI | 1 |
| Belon, JP; Gaudel, G; Martin, P; Massol, J; Soubrié, P | 1 |
| Fujii, T; Taguchi, H | 1 |
| Cohen, BS; Dillon, D; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR | 1 |
| Collins, C; Hu, M; Izutsu, A; Jaklitsch, A; Pankey, S; Pirio, M; Singh, P | 1 |
| Weller, EB; Weller, RA | 1 |
| Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV | 1 |
| Broch, OJ | 1 |
| Fraser, AD; Isner, AF; Susnik, E | 1 |
| Kriechman, AM | 1 |
| Bolte, K; Hughes, CW; Preskorn, SH; Weller, EB; Weller, RA | 1 |
| Arena, A; Pisani, F; Spina, E | 1 |
| Albin, HC; D'Aulnay, JM; Demotes-Mainard, FM; Duchier, AR; Fenelon, JH; Rigal, JG; Vincon, GA | 1 |
| Brochet, DM; Martin, P; Simon, P; Soubrié, P | 1 |
| Adan, F; Allen, D; Coccaro, EF; Cooper, TB | 1 |
| Severson, JA; Wilcox, RE; Woodward, JJ | 1 |
| Bech, P; Brøsen, K; Gram, LF; Klysner, R | 1 |
| Koike, Y; Spina, E | 1 |
| Ambrosini, P; Cooper, T; Davies, M; Fried, J; King, J; Puig-Antich, J; Rabinovich, H; Ryan, ND; Torres, D | 1 |
| Perel, J; Rancurello, M; Sallee, F; Stiller, R | 1 |
| Rosenbaum, JF; Tesar, GE | 1 |
| el Mestikawy, S; Hamon, M; Martin, P; Simon, P; Soubrie, P; Thiebot, MH | 1 |
| Grunhaus, L; Meador-Woodruff, JH | 1 |
| Mahapatra, D; Mahapatra, RK; Paul, SK; Winter, S | 1 |
| Brøsen, K; Gram, LF; Otton, SV | 1 |
| Fischer, W; Heydenreich, F; Rabending, G; Streubel, FR | 1 |
| Haskins, JT; Husbands, GE; Moyer, JA; Muth, EA; Nielsen, ST; Sigg, EB | 1 |
| Greden, JF; Grunhaus, L; Tandon, R | 1 |
| Clark, H; McCurdy, F; Ryan, R; Stigelman, WH; Wians, FH | 1 |
| Hicks, PE; Langer, SZ; Raisman, R; Schoemaker, H; Segonzac, A; Tateishi, T | 1 |
| Chuang, DM; Costa, E; Nakaki, T; Roth, BL | 1 |
| Prange, AJ | 1 |
| Chamberlain, K; Curtis, G; Falcon, S; Ryan, C | 1 |
| Lydiard, RB | 1 |
| Quitkin, FM | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Aihara, H; Araki, H; Kawashima, K; Uchiyama, Y | 1 |
| Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF | 1 |
| Cowen, PJ; Elliott, JM; Geaney, DP; Green, AR; Schächter, M | 1 |
| Albouz, S; Baumann, N; Hauw, JJ; Le Saux, F; Wenger, D | 1 |
| Narasimhachari, N | 1 |
| Roy, EJ; Wilson, MA | 2 |
| Abernethy, DR; Greenblatt, DJ; Shader, RI | 1 |
| Borenstein, M; Brenner, R; Cooper, TB; Kane, JM; Lieberman, JA; Steinberg, H; Suckow, RF | 1 |
| Baldessarini, RJ; Cohen, BM | 1 |
| Davis, JM; Javaid, JI; Maiorano, M | 1 |
| Kameyama, T; Nagasaka, M; Yamada, K | 1 |
| Elley, J; Krautwald, O; Larsen, OB; Møller, SE; Ortmann, J; Reisby, N | 1 |
| Lafaille, F; Nair, NP; Quirion, R; Schwartz, G; Suranyi-Cadotte, BE | 1 |
| Borst, C; de Groot, G; de Wildt, D; Sangster, B | 1 |
| Barnhill, J; Boxenbaum, H; Ciraulo, DA | 1 |
| Bedair, M; el-Yazbi, FA; Korany, MA | 1 |
| Frisk-Holmberg, M; van der Kleijn, E | 1 |
| al-Sarraj, S; Beckett, AH | 1 |
| Davis, RS; McNeill, JH | 1 |
| Nagy, A; Treiber, L | 1 |
| Tuomisto, J | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Schmutz, J | 1 |
| Squires, RF | 1 |
| McNair, DM | 1 |
| Illing, HP; Kunke, S; Netter, KJ | 1 |
| Bickel, MH; Gigon, PL | 1 |
| Sastry, BS; Sinclair, JG | 1 |
| Coffer, AI; McDowall, RD; Robinson, AE | 1 |
| Hishikawa, Y; Ida, H; Kaneko, Z; Nakai, K | 1 |
| Crammer, JL; Scott, B | 1 |
| Mandell, AJ; Spooner, CE; Wallach, MB; Winters, WD | 2 |
| Barthel, W | 1 |
| Baltzer, V; Bein, HJ | 1 |
| Mulder, GJ | 1 |
| Bolan, JC; Glenn, CH; Hardison, MD; Mason, RG; Mohammad, SF; Morton, BD | 1 |
| Loew, D; Taeschler, M | 2 |
| Bhargava, KP; Saxena, PR; Seth, PK; Tangri, KK | 1 |
| Carlsson, A | 2 |
| Koch-Weser, J; Powell, WJ; Williams, RA | 1 |
| Glasser, H; Krieglstein, J | 1 |
| Askari, A; Rao, SN | 1 |
| Chichmanian, RM; Goude, F; Lanza, M | 1 |
| Bickel, MH; Minder, R; Schnetzer, F | 1 |
| Fujisawa, T; Segawa, T | 1 |
| Medzihradsky, F; Nandhasri, PS | 1 |
| Caratsch, CG; Waser, PG | 1 |
| Krieglstein, J; Rieger, H; Stock, R | 1 |
| Dubinsky, B; Goldberg, ME; Karpowicz, JK | 1 |
| Rauws, AG | 1 |
| Bickel, MH; Börner, H | 1 |
| Creech, BJ; Smith, KR | 1 |
| Zingales, I | 1 |
| Blattner, R; Ziegler, E | 1 |
| Nelson, SR; Walaszek, EJ | 1 |
| Hartmann, E | 1 |
| Zung, WW | 2 |
| Abraham, AD; Holan, TS; Pora, EA; Uray, Z | 1 |
| Andén, NE; Fuxe, K; Meek, J | 1 |
| Brown, P; Khazan, N | 1 |
| Eksborg, S; Persson, BA | 1 |
| Clineschmidt, BV; Pierce, JE; Sjoerdsma, A | 1 |
| Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S | 1 |
| Kaniike, K; Kurogochi, Y | 1 |
| Brezinova, V; Dunleavy, DL; Maclean, AW; Oswald, I; Tinker, M | 1 |
| Chang, CC; Chuang, ST | 1 |
| Carskadon, M; Dement, WC; Guilleminault, C | 1 |
| Berndt, S; Schwabe, U | 1 |
| Baba, A; Ishii, K; Iwata, H; Matsuda, T; Terashita, Z | 1 |
| Mlejnkova, M; Rysánek, K; Spánkova, H; Synek, P | 1 |
| Cater, BR; Chapman, D; Hawes, SM; Saville, J | 1 |
| Bellward, GD; Moldowan, M | 1 |
| Gyermek, L; Hill, RT; Sigg, EB | 1 |
| Fassina, G; Santi, R | 1 |
| Bernardi, D; Garattini, S; Jori, A; Morselli, P; Valzelli, L | 1 |
| Mennear, JH; Rudzik, AD | 1 |
| Green, AL | 1 |
| Garattini, S; Jori, A; Paglialunga, S | 1 |
| Breese, GR; Kopin, IJ; Schanberg, SM; Schildkraut, JJ | 2 |
| Berstein, BM; Latimer, CN | 1 |
| Brown, RM; Lal, H | 1 |
| Kuruma, I; Segawa, T; Takagi, H; Takatsuka, K | 1 |
| Bickel, MH; Weder, HJ | 2 |
| Bernardi, D; Jori, A | 1 |
| Randrup, A; Scheel-Krüger, J | 1 |
| Blum, JJ | 1 |
| Otten, U; Zetler, G | 1 |
| Bouttier, D; Julou, L; Sigwald, J; Thomas, J | 1 |
| Tait, AC; Todrick, A | 1 |
| Carlsson, A; Jonason, J; Lindqvist, M | 1 |
| Chandra, O; Dhawan, KN; Gupta, GP; Saxena, RC | 1 |
| Sofia, RD | 2 |
| Colson, SH; Tolson, WW; Umberger, EJ | 1 |
| Nybäck, H; Schubert, J; Sedvall, G | 1 |
| Lippmann, W | 5 |
| Sturman, G | 1 |
| Ahtee, L; Saarnivaara, L | 1 |
| Iversen, LL; Johnston, GA | 2 |
| Campbell, IC; Todrick, A | 1 |
| Fuxe, K; Jonsson, G; Lidbrink, P | 1 |
| Iversen, LL; Iversen, SD; Lew, C | 1 |
| Clark, B; Thompson, JW; Widdrington, G | 1 |
| Schrold, J | 2 |
| Lapin, IP; Oxenkrug, GF | 1 |
| Karobath, M | 1 |
| Gillis, CN; Roth, JA | 2 |
| König, J; Mlejnková, M; Rysánek, K; Spánková, H | 1 |
| Koe, BK; Sarges, R; Schaefer, JP; Weissman, A | 1 |
| Ballinger, BR; Presly, A; Reid, AH; Stevenson, IH | 1 |
| Imai, S; Ogura, C; Okuma, T; Uchida, Y; Yogi, H | 1 |
| Belvedere, G; Frigerio, A; Pantarott, C | 1 |
| Markham, CH | 1 |
| Komissarov, IV; Talalaenko, AN; Zin'kovskaia, LIa | 1 |
| Benesová, O; Rysánek, K; Spánková, H | 1 |
| Bradshaw, CM; Roberts, MH; Szabadi, E | 3 |
| Ceraso, OL; Fernández Pardal, J; Fernández Pardal, MM; López, C; Mateos, MD | 1 |
| Krieglstein, J; Rieger, H | 1 |
| Christiansen, J; Gram, LF; Overo, KF | 1 |
| Blank, HR; Greenberg, HR | 1 |
| Lin, RL; Narasimhachari, N | 1 |
| Cataldi, S; Coscia, L; Marmo, E | 1 |
| Davila, D; Palaić, D; Rabadija, M; Supek, Z | 1 |
| Neuhoff, V; Osborne, NN | 1 |
| Gripenberg, J | 1 |
| Dekirmenjian, H; Fawcett, JA; Maas, JW | 2 |
| Crammer, JL; Elkes, A; Watt, DC | 1 |
| Glassman, AH; Perel, JM | 1 |
| Tolosa, E | 1 |
| Tanimukai, H | 1 |
| Biel, JH; Bopp, B | 1 |
| Bonaccorsi, A; Garattini, S; Jori, A; Samanin, R | 1 |
| Berner, P; Kryspin-Exner, K; Poeldinger, W | 1 |
| Frohman, LA | 1 |
| Fung, HL; Ow, YH | 1 |
| Cano, JP; Gola, C; Gouezo, F; Viala, A | 2 |
| Feldman, S; Gibaldi, M | 1 |
| Garattini, S; Ghezzi, D; Samanin, R | 1 |
| Baumgarten, HG | 1 |
| Binini, R; Bonaccorsi, A; Garattini, S; Morselli, PL; Muscettola, G | 1 |
| O'Malley, K; Sawyer, PR; Stevenson, IH | 1 |
| König, J; Mlejnková, M; Rysánek, K; Spánková, H; Synek, P | 1 |
| Jonsson, G; Sachs, C | 1 |
| Gaut, ZN | 1 |
| Mann, WA; Ridley, PT | 1 |
| Dubnick, B; Rucki, EW; Salama, AI | 1 |
| Roberts, CD; Roberts, EN | 1 |
| Berry, DJ; Grove, J | 1 |
| Bickel, MH; Di Francesco, C; Minder, R | 1 |
| Gaffney, T; Gard, H; Hanenson, I; Knapp, D; Walle, T | 1 |
| Hespe, W; van der Zee, P | 1 |
| Connor, JD; Crawford, IL; Pardridge, WM | 1 |
| Bernasconi, S; Garattini, S; Gerna, M; Ghezzi, D; Samanin, R; Tognoni, G | 1 |
| Boulu, R; Dupeyron, JP; Rossignol, P | 1 |
| Browning, M; O'Malley, K; Stevenson, I; Turnbull, MJ | 1 |
| Dandiya, PC; Kulkarni, SK | 1 |
| Kahan, E; Siwers, B; Tuck, JR | 1 |
| Baumann, FW; Hinman, F | 1 |
| Lassen, JB | 1 |
| Mattila, MJ; Saarnivaara, L | 1 |
| Bellward, GD; Black, NB; Dayton, PG; O'Brien, L; Perel, JM | 1 |
| Hurwic, MJ; Klutch, A; Perel, JM; Winsberg, BG | 1 |
| Baumann, PA; Maitre, L; Staehelin, M; Waldmeier, PC | 1 |
| Falk, MA | 1 |
| Furlong, FW; Luby, ED | 1 |
| Rose, JT; Westhead, TT | 2 |
| Suchenwirth, R | 1 |
| Hills, NF; Milner, G | 1 |
| Maxwell, C; Rose, JT | 1 |
| Deza, PC; Marjerrison, G; Silzer, JC | 1 |
| Vescovini, L | 1 |
| Baker, WW; Kratky, M | 1 |
| Hollister, LE; Overall, JE | 2 |
| Mainard, F; Stephan, Y; Welin, L | 1 |
| Dayton, PG; Malitz, S; Perel, JM; Wharton, RN | 1 |
| Kowa, Y; Nose, T | 1 |
| Constantine, JW; Koe, BK | 1 |
| Scheel-Krüger, J | 2 |
| Borg, KO; Lagerström, PO; Westerlund, D | 1 |
| Maickel, RP; Sokol, GH | 1 |
| Cranston, WI; Hellon, RF; Luff, RH; Rawlins, MD | 3 |
| Andreeva, NI | 1 |
| Aghajanian, GK; Sheard, MH; Zolovick, A | 1 |
| Fawcett, J; Maas, JW | 1 |
| Attree, T; Sawyer, P; Turnbull, MJ | 1 |
| Wand, H | 1 |
| Webb, WL | 1 |
| Brand, U; Menge, HG | 1 |
| Garriott, JC; Stolman, A | 1 |
| Brown, TC; Dwyer, ME; Stocks, JG | 1 |
| Orrenius, S; Sjöqvist, F; von Bahr, C | 1 |
| Begent, NA; Born, GV | 1 |
| Bernardi, D; Garattini, S; Jori, A; Muscettola, G | 1 |
| Oates, JA; Shand, DG | 1 |
| Appel, P; Eckel, K; Harrer, G | 1 |
| Bein, HJ; Maître, L; Staehelin, M | 1 |
| De Carolis, AS; Del Basso, P; Longo, VG; Ziegler, H | 1 |
| Luthe, R; Schmitt, W | 1 |
| Bhargava, KP; Chandra, O; Dixit, KS; Sinha, JA; Srimal, RC | 1 |
| Jaju, BP; Sinha, JN; Srimal, RC | 1 |
| Blackburn, KJ; French, PC; Merrills, RJ | 1 |
| Kulkarni, AS | 1 |
| Hitomi, M; Kumada, S; Kumadaki, N | 1 |
| Bhargava, KP; Dixit, KS; Sinha, JN; Srimal, RC | 1 |
| Lapin, IP; Osipova, SV; Stabrovski, EM; Uskova, NV | 2 |
| Carlsson, A; Fuxe, K; Jonason, J; Lindqvist, M | 1 |
| Edwards, G | 1 |
| Bodi, T; Dykyj, R; Mapp, Y; Nodine, JH; Siegler, PE | 1 |
| Dick, P; Shepherd, M | 1 |
| Gyermek, L | 1 |
| Hargreaves, MA; Maxwell, C | 1 |
| Azarnoff, DL; Borgå, O; Forshell, GP; Sjöqvist, F | 1 |
| Crammer, JL; Rolfe, B; Scott, B | 1 |
| Rohte, O | 3 |
| Dodge, GA; Logue, MA; Schildkraut, JJ | 1 |
| Gola, C; Gouezo, F; Viala, A | 1 |
| Schneider, G | 2 |
| Bickel, MH; Schneider, G | 1 |
| Alpers, HS; Himwich, HE | 1 |
| Hanahoe, TH; Ireson, JD; Large, BJ | 1 |
| Scanlon, FJ | 1 |
| Gröningsson, K; Schill, G | 1 |
| Gross, R; Linker, H; Reuter, H | 1 |
| Aeppli, L | 1 |
| Fischbach, R | 3 |
| Greeff, K; Wagner, J | 2 |
| Opitz, K; Schniedermann, W | 1 |
| Eckhardt, SB; Hite, G; Maxwell, RA | 1 |
| Núnek, K | 1 |
| Bass, AD; Rosenbloom, PM | 1 |
| Ose, E | 1 |
| Foxwell, MH; Funderburk, WH; Hakala, MW | 1 |
| Vohra, MM | 1 |
| Lindström, LH | 1 |
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| Bose, D; Capella-Peiró, ME; Carda-Broch, S; Durgbanshi, A; Esteve-Romero, J; Gil-Agustí, M; Martinavarro-Domínguez, A | 1 |
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| Funae, Y; Hanioka, N; Hichiya, H; Isobe, T; Narimatsu, S; Satoh, T; Shinoda, S; Yamamoto, S; Yamano, S | 1 |
| Ameno, K; Hishida, S; Kinoshita, H; Kubota, A; Minami, T; Motomura, H; Nagasaki, Y; Nishiguchi, M; Ouchi, H; Taniguchi, T; Utsumi, T | 1 |
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| Chen, MF; Chen, PY; Evans, MS; Hoffer, BJ; Lee, TJ; Long, C; Sarwinski, SJ; Si, M | 1 |
| Cantú, MD; Carrilho, E; Lacerda, CA; Lanças, FM; Queiroz, ME; Toso, DR | 1 |
| Chojnacka-Wójcik, E; Nikiforuk, A; Tatarczyńska, E; Wesołowska, A | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Kuśmider, M | 1 |
| Burke, WJ; Bylund, DB; Deupree, JD; Kozisek, ME | 1 |
| Stenken, JA; Sun, L | 1 |
| Bruijn, JA; Lindemans, J; Mathot, RA; Schenk, PW; van Fessem, MA; van Gelder, T; van Schaik, RH; van Vliet, M; Verploegh-Van Rij, S; Vulto, AG | 2 |
| Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M | 1 |
| Bylund, DB; Deupree, JD; Montgomery, MD | 1 |
| Alves, C; Fernandes, C; Lanças, FM; Rodrigues, JC; Santos-Neto, AJ | 1 |
| Nałecz-Jawecki, G | 1 |
| Birk, G; Eichner, J; Fröhlich, H; Hoenselaar, A; Rosenbrock, H; Zell, A | 1 |
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| Belzung, C; Surget, A; Yalcin, I | 1 |
| Alvarez-Gonzalez, I; Baez, R; Madrigal-Bujaidar, E; Madrigal-Santillán, EO; Marquez, P | 1 |
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| Bantsiele, GB; Bentué-Ferrer, D; Bourin, M; Laviolle, B; Reymann, JM; Saïkali, S | 1 |
| Aburakawa, Y; Aizawa, H; Hasebe, N; Kwak, S; Sawada, J; Yamashita, T | 1 |
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| Fast, DM; Groeber, EA; Pabbisetty, D; Song, W; Steenwyk, RC | 1 |
| Alvarez-González, I; Cárdenas García, Y; Madrigal-Bujaidar, E | 1 |
| Allen, KE; Babu, KN; Hanson, KL; Kunze, KL; Nelson, WL; VandenBrink, BM | 1 |
| Balci, F; Campbell, U; Hanania, T; Olivier, BE; Paterson, NE | 1 |
| Hara, H; Hayashi, E; Kinoshita, M; Kuratani, K; Shimamura, M | 1 |
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| Fulda, S; Himmerich, H; Plümäkers, B; Rink, L; Sheldrick, AJ | 1 |
| Frazer, A; Furmaga, H; Shah, A | 1 |
| Jaworska, A; Kościelniak, P; Malek, K; Wietecha-Posłuszny, R; Woźniakiewicz, M | 1 |
| Clarke, G; Cryan, JF; Dinan, TG; Fitzgerald, P; Griffin, BT; O'Brien, FE | 1 |
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| Bohner, LO; Costa, AP; De Lima, TC; Lino-de-Oliveira, C; Santos, EC; Silva, CF; Vieira, C | 1 |
| Cadeddu, R; Carboni, E; Ibba, M; Sadile, A | 1 |
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| Chun, KH; Lee, J; Shin, Y; Yoon, HR; Zhao, J | 1 |
| dos Santos, MF; Leyton, V; Muñoz, DR; Pasqualucci, CA; Seulin, SC; Yamada, A; Yonamine, M | 1 |
| Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X | 1 |
| Callegari, E; Nguyen, HQ; Obach, RS | 1 |
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| Aree, T | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Kusmider, M; Pabian, P; Solich, J | 1 |
| Chmielarz, P; Chorązka, K; Kowalska, M; Kuśmierczyk, J; Nalepa, I; Rafa-Zabłocka, K; Satała, G | 1 |
| Iyama, Y; Onoue, S; Sato, H; Seto, Y; Tonami, R | 1 |
| Giles, R; Girard, MFC; Hopfgartner, G; Knight, P | 1 |
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| Farajzadeh, MA; Hamishehkar, H; Manafi Khoshmanesh, S; Pirmohamadlou, A; Sattari Dabbagh, M | 1 |
58 review(s) available for imipramine and desipramine
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Fluphenazine; Humans; Imipramine; Nortriptyline; Perazine; Phenelzine; Thioridazine | 1976 |
Drug impairment reviews: opiates, minor tranquilizers.
Topics: Amitriptyline; Anti-Anxiety Agents; Automobile Driving; Behavior; Desipramine; Dextropropoxyphene; Diazepam; Ethanol; Humans; Imipramine; Lithium; Methadone; Motor Skills; Narcotics; Task Performance and Analysis | 1977 |
Clinical and biochemical heterogeneity of depressive disorders.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Depression; Desipramine; Dextroamphetamine; Emotions; Humans; Imipramine; Metanephrine; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Norepinephrine; Normetanephrine; Vanilmandelic Acid | 1978 |
Tricyclic antidepressants (first of two parts).
Topics: Aged; Amines; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical Phenomena; Chemistry; Child; Depression; Desipramine; Doxepin; Humans; Imipramine; Kinetics; Neurotransmitter Agents; Nortriptyline; Protriptyline | 1978 |
Poisoning by tricyclic antidepressant drugs: general and pharmacokinetic considerations.
Topics: Accidents, Home; Adolescent; Adult; Aged; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain Chemistry; Child; Child, Preschool; Desipramine; Dibenzazepines; Drug Interactions; Female; Humans; Imipramine; Infant; Intestinal Absorption; Kinetics; Liver; Lung; Male; Mice; Middle Aged; Nortriptyline; Opipramol; Poisoning; Protein Binding; Rats; Suicide | 1975 |
Quantitative mass spectrometry in biochemistry and medicine.
Topics: Animals; Body Fluids; Chemistry, Clinical; Clinical Laboratory Techniques; Computers; Cyclophosphamide; Desipramine; Dextropropoxyphene; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Isotopes; Kinetics; Mass Spectrometry; Pharmaceutical Preparations; Radioisotope Dilution Technique | 1978 |
The emergence of suicidal ideation and behavior during antidepressant pharmacotherapy.
Topics: Antidepressive Agents; Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Fluvoxamine; Humans; Imipramine; Mianserin; Suicide | 1991 |
Clinical pharmacokinetics of imipramine and desipramine.
Topics: Biological Availability; Desipramine; Humans; Imipramine; Intestinal Absorption; Tissue Distribution | 1990 |
[Antidepressant drugs and central monoaminergic receptors].
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Antipsychotic Agents; Binding Sites; Blood Platelets; Brain; Brain Chemistry; Cats; Clonidine; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Mianserin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Yohimbine | 1985 |
Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.
Topics: Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Clinical Trials as Topic; Depressive Disorder; Desipramine; Hospitalization; Humans; Imipramine; Laboratories; Nortriptyline; Outcome and Process Assessment, Health Care; Research Design | 1985 |
Psychotropic drugs and the thyroid axis: a review of interactions.
Topics: Animals; Body Temperature; Brain; Chlorpromazine; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hyperthyroidism; Imipramine; Male; Mice; Psychotropic Drugs; Schizophrenia; Thyroid Gland; Thyroid Hormones; Triiodothyronine | 1985 |
Tricyclic-resistant depression: treatment resistance or inadequate treatment?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Intestinal Absorption; Kinetics; Nortriptyline; Patient Compliance | 1985 |
The importance of dosage in prescribing antidepressants.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Monoamine Oxidase Inhibitors; Phenelzine | 1985 |
[Intention and incident in drug research, demonstrated on the example of tricyclic psychopharmacologic agents].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Azepines; Chemical Phenomena; Chemistry; Chlorpromazine; Desipramine; Humans; Imipramine; Mental Disorders; Research; Structure-Activity Relationship; Tranquilizing Agents | 1973 |
Self-evaluations of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine | 1974 |
Pharmacology of the central nervous system.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Adrenocorticotropic Hormone; Amphetamine; Anger; Angiotensin II; Animals; Avoidance Learning; Behavior, Animal; Cats; Central Nervous System; Central Nervous System Diseases; Chick Embryo; Desipramine; Dogs; Guanethidine; Guinea Pigs; Humans; Hypnotics and Sedatives; Imipramine; Memory; Mice; Norepinephrine; Parkinson Disease; Phenacetin; Phenothiazines; Phenoxybenzamine; Rabbits; Rats; Reserpine; Serotonin; Sleep; Sleep, REM; Synapses; Synaptic Transmission; Tetrodotoxin; Theophylline | 1968 |
Pharmacological studies of sleep and dreaming: chemical and clinical relationships.
Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Atropine; Chloralose; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Diazepam; Diphenhydramine; Dreams; Glutethimide; Humans; Hypnotics and Sedatives; Imipramine; Lysergic Acid Diethylamide; Meprobamate; Methaqualone; Morphine; Nialamide; Pentobarbital; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tranylcypromine; Triiodothyronine; Tryptophan | 1969 |
Antidepressant drugs and sleep.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents; Arousal; Brain; Cats; Depression; Desipramine; Electroencephalography; Electromyography; Electrooculography; Female; Humans; Imipramine; Male; Monoamine Oxidase Inhibitors; Sleep; Sleep, REM | 1969 |
The pharmacology of disordered sleep: a laboratory approach.
Topics: Amitriptyline; Anxiety; Arousal; Barbiturates; Brain; Cerebral Cortex; Depression; Desipramine; Humans; Hypothalamus; Imipramine; Limbic System; Meprobamate; Phenothiazines; Reticular Formation; Schizophrenia; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Thalamus | 1970 |
The clinical pharmacology of imipramine. Implications for therapeutics.
Topics: Administration, Oral; Barbiturates; Cell Membrane Permeability; Depression; Desipramine; Drug Interactions; Enzyme Induction; Humans; Hydroxylation; Imipramine; Mental Disorders; Methylphenidate; Protein Binding | 1973 |
Parkinson's disease; modern treatment.
Topics: Amantadine; Amphetamine; Antidepressive Agents; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase Inhibitors; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Drug Incompatibility; Drug Synergism; Humans; Imipramine; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease | 1973 |
[Appraisal of pharmacotherapy of affective disorders].
Topics: Adolescent; Depression; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Monoamine Oxidase Inhibitors | 1973 |
Antidepressant drugs.
Topics: Amitriptyline; Antidepressive Agents; Carbazoles; Chlorpromazine; Desipramine; Imipramine; Molecular Conformation; Opipramol; Structure-Activity Relationship; Tripelennamine | 1974 |
MHPG excretion by patients with affective disorders.
Topics: Affective Symptoms; Bipolar Disorder; Brain; Catecholamines; Creatinine; Depression; Desipramine; Dextroamphetamine; Female; Glycols; Humans; Imipramine; Intellectual Disability; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Normetanephrine; Physical Exertion; Vanilmandelic Acid | 1974 |
[Monoamines and the pharmacological effects of tricyclic antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Central Nervous System; Chemical Phenomena; Chemistry; Desipramine; Humans; Hydroxyindoleacetic Acid; Imipramine; Methyltransferases; Monoamine Oxidase; Norepinephrine; Nortriptyline; Receptors, Drug; Serotonin | 1972 |
Clinical neuropharmacology of hypothalamic releasing factors.
Topics: Amphetamine; Animals; Brain; Corticotropin-Releasing Hormone; Desipramine; Dopamine; Follicle Stimulating Hormone; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Imipramine; Luteinizing Hormone; Neurons; Neurosecretion; Norepinephrine; Phenothiazines; Pituitary Hormone-Releasing Hormones; Prolactin; Reserpine; Serotonin; Thyrotropin-Releasing Hormone | 1972 |
[Studies on the biochemistry and pharmacology of thymoleptics].
Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Catecholamines; Cats; Depression; Desipramine; Humans; Imipramine; Mice; Monoamine Oxidase Inhibitors; Rabbits; Rats; Reserpine; Sympathomimetics | 1968 |
Indications for tricyclic antidepressant drugs.
Topics: Antidepressive Agents; Chlorpromazine; Depression; Desipramine; Drug Interactions; Humans; Imipramine; Phenothiazines; Time Factors | 1971 |
The pharmacology of imipramine and related antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Catecholamines; Chemical Phenomena; Chemistry; Desipramine; Electroencephalography; Humans; Imipramine; Parasympatholytics; Reserpine; Serotonin | 1966 |
Noradrenergic function and depression, too much or too little?
Topics: Amphetamine; Bipolar Disorder; Brain; Brain Chemistry; Desipramine; Electroconvulsive Therapy; Humans; Imipramine; Iprindole; Methoxyhydroxyphenylglycol; Norepinephrine; S-Adenosylmethionine; Tyrosine 3-Monooxygenase | 1980 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Monoamine Oxidase Inhibitors; Personality Disorders; Phenelzine; Propranolol; Psychotropic Drugs; Schizophrenia | 1982 |
Central 5-HT neurons as targets for antidepressant drug action: differential modulation of 5-HT receptor populations in the central nervous system of the rat.
Topics: Animals; Antidepressive Agents; Autoradiography; Avoidance Learning; Binding Sites; Central Nervous System; Desipramine; Histocytochemistry; Imipramine; Immunochemistry; Methoxydimethyltryptamines; Movement; Rats; Receptors, Serotonin; Spiperone; Zimeldine | 1984 |
Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Brain; Carrier Proteins; Depressive Disorder; Desipramine; Humans; Imipramine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Tritium | 1983 |
Pharmacodynamics of nomifensine: a review of studies in healthy subjects.
Topics: Administration, Oral; Adult; Arousal; Biological Availability; Cognition; Desipramine; Dose-Response Relationship, Drug; Electroencephalography; Emotions; Humans; Imipramine; Injections, Intravenous; Isoquinolines; Nomifensine; Prolactin; Psychomotor Performance; Sleep; Wakefulness | 1984 |
3H-imipramine and 3H-desipramine binding sites in depression.
Topics: Animals; Antidepressive Agents; Binding Sites; Biogenic Amines; Biological Transport; Blood Platelets; Brain; Depressive Disorder; Desipramine; Humans; Imipramine; Longitudinal Studies; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin | 1984 |
Antidepressant binding sites in brain.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Binding Sites; Blood Platelets; Brain; Depressive Disorder; Desipramine; Humans; Imipramine; Rats; Serotonin; Tritium | 1984 |
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepines; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Gastric Mucosa; Glomerular Filtration Rate; Humans; Imipramine; Kinetics; Middle Aged; Nordazepam; Nortriptyline | 1984 |
The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Doxepin; Heart; Humans; Imipramine; Nortriptyline; Protriptyline | 1980 |
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; Child; Depression; Desipramine; Doxepin; Electrocardiography; Hemodynamics; Humans; Hypotension; Imipramine; Kinetics; Middle Aged; Myocardium; Norepinephrine; Parasympatholytics; Protriptyline | 1982 |
Current concepts in psychiatry. Panic attacks and phobias.
Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents; Anxiety Disorders; Behavior Therapy; Clinical Trials as Topic; Desipramine; Diagnosis, Differential; Fear; Female; Humans; Imipramine; Male; Panic; Phenelzine; Phobic Disorders; Prognosis; Psychotherapy; Tranquilizing Agents | 1982 |
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Contraindications; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Imipramine; Long QT Syndrome; Nortriptyline; Practice Guidelines as Topic | 1995 |
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; ROC Curve; Sensitivity and Specificity | 1994 |
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.
Topics: Clomipramine; Cytochromes; Dealkylation; Depressive Disorder; Desipramine; Dextromethorphan; Drug Interactions; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Nortriptyline; Phenotype; Polymorphism, Genetic | 1994 |
[Tricyclic antidepressants (imipramine, desipramine, amitriptyline, nortriptyline)].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Drug Monitoring; Humans; Imipramine | 1995 |
Death of two subjects due to imipramine and desipramine metabolite accumulation during chronic therapy: a review of the literature and possible mechanisms.
Topics: Adult; Antidepressive Agents, Tricyclic; Child; Death, Sudden; Desipramine; Female; Humans; Imipramine; Male; Time Factors | 1997 |
Cardiovascular effects of tricyclic antidepressants in childhood asthma: a case series and review.
Topics: Adolescent; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Asthma; Blood Pressure; Bronchodilator Agents; Cardiovascular System; Child; Depressive Disorder; Desipramine; Electrocardiography; Female; Heart Rate; Humans; Imipramine; Male; Nortriptyline; Treatment Outcome | 1997 |
Clinical pharmacokinetics of acamprosate.
Topics: Acamprosate; Age Factors; Alcohol Deterrents; Animals; Desipramine; Diazepam; Disulfiram; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Food-Drug Interactions; Humans; Imipramine; Psychotropic Drugs; Sex Characteristics; Taurine | 1998 |
Treatment of attention-deficit/hyperactivity disorder.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child Behavior; Combined Modality Therapy; Desipramine; Dextroamphetamine; Evidence-Based Medicine; Follow-Up Studies; Humans; Imipramine; Methylphenidate; Nicotine; Nicotinic Agonists; Pemoline; Phenylalanine; Placebos; Randomized Controlled Trials as Topic; Safety; Treatment Outcome | 1999 |
CURRENT STATUS OF DRUG TREATMENT IN THE DEPRESSIVE STATE.
Topics: Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Aspartic Acid; Benactyzine; Classification; Deanol; Depression; Desipramine; Humans; Imipramine; Isocarboxazid; Methylphenidate; Monoamine Oxidase Inhibitors; Nialamide; Pargyline; Pharmacology; Phenelzine; Phenmetrazine; Piperidines; Sympathomimetics; Toxicology; Tranylcypromine | 1964 |
THE PHARMACOTHERAPY OF THE DEPRESSIVE SYNDROME.
Topics: Amitriptyline; Antidepressive Agents; Convulsive Therapy; Depression; Depressive Disorder; Desipramine; Drug Therapy; Electroconvulsive Therapy; Imipramine; Mental Disorders; Monoamine Oxidase Inhibitors; Psychopharmacology; Psychotherapy; Toxicology; Tranquilizing Agents | 1965 |
THE ANTIDEPRESSANT DRUGS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Depression; Depressive Disorder; Desipramine; Drug Therapy; Epidemiology; Humans; Imipramine; Mental Disorders; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Psychopharmacology | 1965 |
The safety of non-stimulant agents for the treatment of attention-deficit hyperactivity disorder.
Topics: Adrenergic alpha-Agonists; Adult; Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; Clonidine; Desipramine; Guanfacine; Humans; Imipramine; Nortriptyline; Propylamines | 2005 |
Nocturnal enuresis.
Topics: Acupuncture Therapy; Age Factors; Antidepressive Agents, Tricyclic; Desipramine; Genetic Linkage; Humans; Imipramine; Nocturnal Enuresis; Pedigree; Prospective Studies; Time Factors | 2007 |
Clinical psychopharmacology and medical malpractice: the four Ds.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder; Desipramine; Fatal Outcome; Female; Fluvoxamine; Forensic Psychiatry; Humans; Imipramine; Male; Malpractice; Mental Disorders; Psychopharmacology; Schizophrenia; Thioridazine | 2014 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride | 2016 |
71 trial(s) available for imipramine and desipramine
| Article | Year |
|---|---|
Comparative clinical evaluation of lofepramine and imipramine. Pharmacological aspects.
Topics: Adult; Chromatography, Gas; Clinical Trials as Topic; Depression; Desipramine; Drug Evaluation; Female; Humans; Imipramine; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales | 1977 |
Antidepressant drug therapy in psychotic depression.
Topics: Adult; Affective Disorders, Psychotic; Clinical Trials as Topic; Delusions; Desipramine; Double-Blind Method; Drug Evaluation; Female; Humans; Imipramine; Male; Middle Aged; Monoamine Oxidase; Phenelzine; Psychotic Disorders | 1977 |
Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Biopharmaceutics; Clinical Trials as Topic; Depression; Desipramine; Doxepin; Erythrocytes; Humans; Imipramine; Middle Aged; Nortriptyline | 1978 |
[Differential indications for desipramine--results of a controlled multiclinical study].
Topics: Clinical Trials as Topic; Depression; Desipramine; Double-Blind Method; Humans; Imipramine | 1978 |
Imipramine and desipramine in plasma and spinal fluid: relationship to clinical response and serotonin metabolism.
Topics: Adult; Bipolar Disorder; Brain; Clinical Trials as Topic; Depression; Desipramine; Double-Blind Method; Female; Humans; Hydroxyindoleacetic Acid; Imipramine; Male; Middle Aged; Serotonin | 1978 |
Effect of imipramine on norepinephrine and blood pressure in enuretic boys.
Topics: Blood Pressure; Child; Clinical Trials as Topic; Desipramine; Double-Blind Method; Enuresis; Heart Rate; Humans; Imipramine; Male; Norepinephrine; Posture; Scopolamine Derivatives | 1979 |
Plasma levels and antidepressive effect of imipramine.
Topics: Adult; Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Placebos; Psychiatric Status Rating Scales | 1976 |
[Experiences with Petylyl (desipramine) in antidepressive therapy. Double blind test with Pryleugan (imipramine)].
Topics: Clinical Trials as Topic; Depression; Desipramine; Drug Evaluation; Humans; Imipramine | 1976 |
Plasma levels of imipramine and desipramine in man after different routes of administration.
Topics: Administration, Oral; Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Desipramine; Drug Administration Schedule; Female; Half-Life; Humans; Imipramine; Injections, Intramuscular; Injections, Intravenous; Kinetics; Male | 1975 |
Pharmacodynamics of imipramine in depressed patients.
Topics: Clinical Trials as Topic; Depression; Desipramine; Half-Life; Humans; Imipramine; Phenylbutazone | 1975 |
Lack of effect of mianserin on the symptoms of diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Desipramine; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Imipramine; Male; Mianserin; Middle Aged | 1992 |
Combined treatment with imipramine and mianserin. A controlled pilot study.
Topics: Adult; Aged; Aged, 80 and over; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Mianserin; Middle Aged; Pilot Projects; Psychiatric Status Rating Scales | 1992 |
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil | 1992 |
Pediatric cardiovascular effects of imipramine and desipramine.
Topics: Adolescent; Anxiety Disorders; Child; Depressive Disorder; Desipramine; Double-Blind Method; Electrocardiography; Female; Heart Block; Humans; Imipramine; Male; Pilot Projects | 1991 |
Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects.
Topics: Adolescent; Adult; Amino Acids; Blood-Brain Barrier; Depressive Disorder; Desipramine; Double-Blind Method; Eating; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Tryptophan | 1990 |
The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms.
Topics: Depression; Desipramine; Diabetic Neuropathies; Humans; Imipramine; Nervous System; Osmolar Concentration; Paroxetine; Piperidines; Serotonin Antagonists; Time Factors | 1990 |
A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants.
Topics: Adult; Depressive Disorder; Desipramine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Thyroid Function Tests; Thyroxine; Triiodothyronine | 1990 |
Possible influence of carbamazepine on plasma imipramine concentrations in children with attention deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Child, Preschool; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Retrospective Studies | 1990 |
Response to alternative antidepressants in imipramine nonresponders with bulimia nervosa.
Topics: Adolescent; Adult; Antidepressive Agents; Bulimia; Clinical Trials as Topic; Desipramine; Feeding Behavior; Female; Fluoxetine; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nortriptyline; Random Allocation | 1989 |
The influence of the route of administration of imipramine on imipramine and desipramine blood levels.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Imipramine; Injections, Intramuscular; Male; Middle Aged | 1989 |
A pilot controlled study of the use of imipramine to reduce myotonia.
Topics: Adult; Desipramine; Double-Blind Method; Drug Evaluation; Female; Humans; Imipramine; Male; Middle Aged; Myotonic Dystrophy; Pilot Projects; Random Allocation | 1989 |
Comparison of the serum levels in primary non-agitated depressed out-patients treated with imipramine in combination with placebo, diazepam or dixyrazine.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Phenothiazines; Random Allocation | 1987 |
Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients.
Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Double-Blind Method; Drug Therapy, Combination; Humans; Imipramine; Random Allocation; Substance Withdrawal Syndrome | 1988 |
Sodium lactate infusions after treatment with tricyclic antidepressants: behavioral and physiological findings.
Topics: Antidepressive Agents, Tricyclic; Arousal; Clinical Trials as Topic; Desipramine; Double-Blind Method; Doxepin; Fear; Humans; Imipramine; Isoproterenol; Lactates; Lactic Acid; Nortriptyline; Panic; Psychological Tests | 1988 |
Tricyclic antidepressants in prepubertal depressed children: review of the literature.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Humans; Imipramine | 1986 |
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine | 1986 |
Depression in prepubertal children: dexamethasone nonsuppression predicts differential response to imipramine vs. placebo.
Topics: Child; Depressive Disorder; Desipramine; Dexamethasone; Humans; Imipramine; Placebos | 1987 |
[Quantitative EEG analysis of a single dose of psychotropic drugs in healthy probands].
Topics: Adult; Arousal; Brain; Carbamazepine; Clomipramine; Desipramine; Diazepam; Electroencephalography; Evoked Potentials; Female; Haloperidol; Humans; Imipramine; Male; Psychotropic Drugs | 1986 |
Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry.
Topics: Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Clinical Trials as Topic; Depressive Disorder; Desipramine; Hospitalization; Humans; Imipramine; Laboratories; Nortriptyline; Outcome and Process Assessment, Health Care; Research Design | 1985 |
Tricyclics: possible treatment for posttraumatic stress disorder.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Combat Disorders; Desipramine; Doxepin; Humans; Imipramine; Male; Manuals as Topic; Middle Aged; Psychiatric Status Rating Scales; Retrospective Studies; Stress Disorders, Post-Traumatic | 1985 |
Self-evaluations of antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine | 1974 |
Changes during weeks in effects of tricyclic drugs on the human sleeping brain.
Topics: Adult; Antidepressive Agents; Brain Chemistry; Desipramine; Dibenzazepines; Dibenzoxepins; Electroencephalography; Humans; Imipramine; Iprindole; Male; Motor Activity; Placebos; Sleep; Sleep, REM; Time Factors | 1972 |
Catecholamine metabolism, depressive illness, and drug response.
Topics: Adult; Aged; Brain; Brain Chemistry; Catechols; Clinical Trials as Topic; Depression; Desipramine; Evaluation Studies as Topic; Female; Glycols; Humans; Imipramine; Male; Middle Aged; Norepinephrine; Normetanephrine; Psychiatric Status Rating Scales; Vanilmandelic Acid | 1972 |
Metabolism, anticholinergic effects, and therapeutic outcome of desmethylimipramine in depressive illness.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Depression; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Middle Aged; Parasympatholytics; Placebos; Salivation; Xerostomia | 1972 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipramine; Drug Resistance; Drug Therapy, Combination; Electroconvulsive Therapy; Humans; Imipramine; Nortriptyline; Remission, Spontaneous; Time Factors; Tranquilizing Agents | 1974 |
Lithium in the control of mania.
Topics: Adult; Amitriptyline; Bipolar Disorder; Chlorpromazine; Clinical Trials as Topic; Desipramine; Female; Humans; Imipramine; Lithium; Male; Middle Aged; Nortriptyline; Thioridazine; Tranylcypromine; Trifluoperazine | 1967 |
Treatment of depression. A comparative trial of imipramine and desipramine.
Topics: Adult; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Male | 1967 |
A double-blind assessment of antidepressants in the treatment of 212 enuretic patients.
Topics: Clinical Trials as Topic; Desipramine; Enuresis; Epilepsy; Female; Humans; Humidity; Imipramine; Male; Mental Disorders; Nortriptyline; Sex Factors; Temperature | 1968 |
Depression: prognosis and drug treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Obsessive-Compulsive Disorder; Prognosis; Psychiatric Status Rating Scales; Thioridazine; Time Factors | 1969 |
Verbal behaviour changes with depression treatment.
Topics: Adolescent; Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Interpersonal Relations; Interview, Psychological; Male; Middle Aged; Nortriptyline; Placebos; Psychiatric Status Rating Scales; Self Concept; Verbal Behavior | 1969 |
[Clinical research on a new antidepressive drug (desipramine) and its comparison with imipramine].
Topics: Adult; Aged; Clinical Trials as Topic; Desipramine; Female; Humans; Imipramine; Middle Aged; Psychopharmacology; Psychotic Disorders | 1969 |
Depression and MHPG excretion. Response to dextroamphetamine and tricyclic antidepressants.
Topics: Adult; Affect; Antidepressive Agents; Brain Chemistry; Catechols; Depression; Desipramine; Dextroamphetamine; Evaluation Studies as Topic; Female; Glycols; Humans; Imipramine; Male; Middle Aged; Norepinephrine; Placebos; Prognosis; Psychological Tests; Sulfates | 1972 |
Comparison of the effect of imipramine and desipramine on some symptoms of depressive illness.
Topics: Adult; Anorexia Nervosa; Anxiety; Clinical Trials as Topic; Depression; Desipramine; Humans; Imipramine; Middle Aged; Psychopharmacology; Sleep Initiation and Maintenance Disorders | 1965 |
A variable dose phase 3, human bioassay of nortriptyline.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1965 |
A study of the interaction between desmethylimipramine and tetrabenazine in normal man.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Desipramine; Humans; Imipramine; Injections, Intramuscular; Placebos; Psychological Tests; Pulse; Pupil; Reaction Time; Reserpine; Tetrabenazine | 1965 |
The speed of action of desipramine: a controlled trial.
Topics: Adolescent; Adult; Clinical Trials as Topic; Depression; Desipramine; Female; Humans; Imipramine; Middle Aged | 1967 |
A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression.
Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Psychometrics; Trazodone | 1983 |
Duration of antidepressant drug treatment. What is an adequate trial?
Topics: Actuarial Analysis; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Desipramine; Humans; Imipramine; Mianserin; Outcome and Process Assessment, Health Care; Phenelzine; Placebos; Psychiatric Status Rating Scales; Time Factors | 1984 |
Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Correlations with the neurobiologic actions of tricyclic antidepressant drugs and lithium ion on the serotonin system.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doxepin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Lithium; Lithium Carbonate; Male; Middle Aged; Neurons; Psychiatric Status Rating Scales; Serotonin; Trimipramine | 1983 |
Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats.
Topics: Adult; Animals; Blood Platelets; Blood Pressure; Bupropion; Clonidine; Desipramine; Heart Rate; Humans; Imipramine; In Vitro Techniques; Male; Propiophenones; Rats; Rats, Inbred Strains; Tritium; Yohimbine | 1984 |
The analysis and disposition of imipramine and its active metabolites in man.
Topics: Administration, Oral; Biotransformation; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Injections, Intramuscular; Kinetics; Male | 1984 |
The relationship of plasma imipramine and N-desmethylimipramine to improvement in agoraphobia.
Topics: Adult; Agoraphobia; Desipramine; Female; Humans; Imipramine; Male; Phobic Disorders | 1984 |
Desmethylimipramine and imipramine on left ventricular function and the ECG: a randomized crossover design.
Topics: Adult; Aged; Blood Pressure; Depressive Disorder; Desipramine; Double-Blind Method; Echocardiography; Electrocardiography; Female; Heart; Heart Ventricles; Humans; Imipramine; Male; Middle Aged; Random Allocation; Systole | 1983 |
Enuresis: psychopathology, sleep stage, and drug response.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Behavior Therapy; Child; Child Behavior Disorders; Clinical Trials as Topic; Desipramine; Double-Blind Method; Enuresis; Humans; Imipramine; Male; Parasympatholytics; Scopolamine Derivatives; Sleep Stages | 1980 |
Childhood enuresis. II. Psychopathology, tricyclic concentration in plasma, and antienuretic effect.
Topics: Child; Clinical Trials as Topic; Desipramine; Double-Blind Method; Enuresis; Humans; Imipramine; Male; Mental Disorders; N-Methylscopolamine; Placebos; Scopolamine Derivatives | 1980 |
Relationship between plasma antidepressant levels and clinical outcome for inpatients receiving imipramine.
Topics: Adult; Aged; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales; Pyrrolidines; Random Allocation | 1982 |
Current concepts in psychiatry. Panic attacks and phobias.
Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents; Anxiety Disorders; Behavior Therapy; Clinical Trials as Topic; Desipramine; Diagnosis, Differential; Fear; Female; Humans; Imipramine; Male; Panic; Phenelzine; Phobic Disorders; Prognosis; Psychotherapy; Tranquilizing Agents | 1982 |
Single-dose kinetics predict steady-state concentrations on imipramine and desipramine.
Topics: Adolescent; Adult; Affective Symptoms; Aged; Chromatography, Gas; Desipramine; Female; Humans; Imipramine; Kinetics; Male; Mass Spectrometry; Middle Aged; Time Factors | 1980 |
Post-stroke depression: combined treatment with imipramine or desipramine and mianserin. A controlled clinical study.
Topics: Aged; Cerebrovascular Disorders; Depressive Disorder; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Mianserin; Psychiatric Status Rating Scales | 1994 |
Cost-effectiveness comparisons using "real world" randomized trials: the case of new antidepressant drugs.
Topics: Antidepressive Agents; Cost-Benefit Analysis; Desipramine; Drug Costs; Fluoxetine; Humans; Imipramine; Patient Compliance; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; United States | 1995 |
Plasma levels and efficacy of imipramine treatment for enuresis.
Topics: Adolescent; Ambulatory Care; Child; Desipramine; Dose-Response Relationship, Drug; Enuresis; Female; Humans; Imipramine; Male; Single-Blind Method; Treatment Outcome | 1994 |
Changes in the frequency distribution pattern of body weight in patients with major depression.
Topics: Adult; Antidepressive Agents, Tricyclic; Body Weight; Clomipramine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hospitalization; Humans; Imipramine; Male; Middle Aged; Personality Inventory; Sex Factors; Weight Gain; Weight Loss | 1993 |
A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Lithium Carbonate; Male; Placebos; Psychiatric Status Rating Scales; Triiodothyronine | 1993 |
Initial antidepressant choice in primary care. Effectiveness and cost of fluoxetine vs tricyclic antidepressants.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Desipramine; Drug Costs; Drug Utilization; Drug Utilization Review; Family Practice; Female; Fluoxetine; Health Maintenance Organizations; Humans; Imipramine; Male; Middle Aged; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Quality of Life; Washington | 1996 |
The relationship of plasma imipramine and N-desmethylimipramine to response in panic disorder.
Topics: Adult; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Panic Disorder | 1996 |
Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects.
Topics: Administration, Oral; Adult; Antidepressive Agents, Tricyclic; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Desipramine; Drug Interactions; Humans; Imipramine; Ketoconazole; Kinetics; Male; Middle Aged; Mixed Function Oxygenases | 1997 |
The effect of sertraline on the pharmacokinetics of desipramine and imipramine.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Desipramine; Half-Life; Humans; Imipramine; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Do depressed subjects who have failed both fluoxetine and a tricyclic antidepressant respond to the combination?
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Humans; Imipramine; Middle Aged; Personality Inventory; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1999 |
Effect of venlafaxine on imipramine metabolism.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6; Desipramine; Drug Interactions; Humans; Imipramine; Male; Middle Aged; Phenotype; Venlafaxine Hydrochloride | 2000 |
Relative bioavailability of imipramine (Tofranil) coated tablets in healthy volunteers.
Topics: Administration, Oral; Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Cross-Over Studies; Desipramine; Half-Life; Humans; Imipramine; Male; Tablets | 2001 |
TDM-based imipramine treatment in neuropathic pain.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Desipramine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Imipramine; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Prospective Studies; Treatment Outcome | 2004 |
1058 other study(ies) available for imipramine and desipramine
| Article | Year |
|---|---|
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 5. Conformationally mobile analogues derived by furan ring opening.
Topics: Animals; Antidepressive Agents; Benzofurans; Brain; In Vitro Techniques; Mice; Norepinephrine; Piperidines; Rats; Spiro Compounds; Structure-Activity Relationship; Synaptosomes; Tetrabenazine | 1979 |
Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen.
Topics: Animals; Antidepressive Agents; Benzofurans; Blepharoptosis; Methods; Mice; Piperidines; Structure-Activity Relationship; Tetrabenazine | 1977 |
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Binding, Competitive; Biological Assay; Biological Transport; Brain; Chemical Phenomena; Chemistry, Physical; Crystallography; Hypothermia; Imipramine; In Vitro Techniques; Models, Molecular; Neurotransmitter Agents; Norepinephrine; Phenethylamines; Rats; Receptors, Adrenergic, beta; Receptors, Serotonin; Reserpine; Serotonin; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Catecholamines; Chemical Phenomena; Chemistry; Dopamine; Isoquinolines; Male; Molecular Conformation; Motor Activity; Norepinephrine; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Synaptosomes; Tetrabenazine | 1987 |
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles | 1988 |
1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants.
Topics: Amino Acids; Animals; Antidepressive Agents; Behavior, Animal; Blepharoptosis; Cyclopropanes; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Spectrophotometry, Infrared; Structure-Activity Relationship; Yohimbine | 1987 |
Synthesis and antidepressant profiles of phenyl-substituted 2-amino- and 2-[(alkoxycarbonyl)amino]-1,4,5,6-tetrahydropyrimidines.
Topics: Amines; Animals; Antidepressive Agents; Dopamine; Mice; Norepinephrine; Pyrimidines; Structure-Activity Relationship | 1985 |
Tetracyclic pyridazines as potential psychopharmacological agents.
Topics: Animals; Biological Assay; Cerebral Cortex; Chemical Phenomena; Chemistry; Chlorprothixene; Isomerism; Magnetic Resonance Spectroscopy; Mice; Norepinephrine; Psychotropic Drugs; Pyridazines; Rats; Serotonin; Structure-Activity Relationship | 1985 |
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship | 1981 |
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.
Topics: Animals; Biogenic Amines; Brain; Brompheniramine; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Mice; Molecular Conformation; Neurons; Norepinephrine; Pyridines; Serotonin; Structure-Activity Relationship; Zimeldine | 1981 |
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Enzyme Inhibitors; Histamine H1 Antagonists; Micelles; Models, Biological; Norepinephrine; Rats; Receptors, Adrenergic, alpha-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Structure-Activity Relationship | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis | 2000 |
Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.
Topics: Animals; Anthracenes; Cell Line; Ligands; Molecular Conformation; Molecular Structure; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists | 2001 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
A new class of antiarrhythmic-defibrillatory agents.
Topics: Animals; Anti-Arrhythmia Agents; Cats; Dibenzazepines; Structure-Activity Relationship; Ventricular Fibrillation | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Electrophysiology; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Heart; Humans; Myocardium; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Xenopus laevis | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.
Topics: Animals; Azides; Cocaine; Cyanogen Bromide; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Epitopes; Humans; Iodine Radioisotopes; Methionine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Rats; Trypsin | 2007 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Topics: Amino Acid Sequence; Animals; Antidepressive Agents, Tricyclic; Bacterial Proteins; Binding Sites; Caenorhabditis elegans Proteins; Cell Line; Conserved Sequence; Crystallography, X-Ray; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Drosophila Proteins; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Plasma Membrane Neurotransmitter Transport Proteins; Protein Binding; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Sequence Homology, Amino Acid; Serotonin | 2007 |
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Toward prediction of alkane/water partition coefficients.
Topics: Alkanes; Central Nervous System; Molecular Structure; Static Electricity; Surface Properties; Water | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors.
Topics: Binding Sites; Computer Simulation; Databases, Factual; Models, Chemical; Models, Molecular; Molecular Structure; Molecular Weight; Psychotropic Drugs; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.
Topics: Animals; Cyclopropanes; Dopamine Plasma Membrane Transport Proteins; Duloxetine Hydrochloride; Humans; Norepinephrine Plasma Membrane Transport Proteins; Plasma Membrane Neurotransmitter Transport Proteins; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine | 2011 |
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.
Topics: Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Imipramine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Lactams; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Pyrrolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins | 2013 |
2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character.
Topics: Amination; Animals; Antidepressive Agents; Anura; Halogenation; Hindlimb Suspension; Mice; Quinazolines; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding | 2014 |
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies | 2014 |
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins | 2014 |
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship | 2014 |
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2015 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2016 |
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries | 2017 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation.
Topics: Apoptosis; Cell Line; Cells, Cultured; Ceramides; Enzyme Inhibitors; Humans; Inflammation; Lipopolysaccharides; Lysosomes; Macrophages; Signal Transduction; Sphingomyelin Phosphodiesterase | 2018 |
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Cricetulus; Dose-Response Relationship, Drug; Humans; Molecular Structure; Quinolines; Structure-Activity Relationship; Tacrine | 2018 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors | 2018 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine | 2019 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
Topics: | 2022 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate | 2022 |
Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats.
Topics: Administration, Oral; Animals; Clomipramine; Desipramine; Dibenzazepines; Imipramine; Injections, Intramuscular; Male; Rats; Time Factors | 1977 |
The neuropharmacology of depression.
Topics: Amitriptyline; Brain; Brain Chemistry; Depression; Desipramine; Dopamine; Humans; Imipramine; Models, Neurological; Neurotransmitter Agents; Norepinephrine; Serotonin; Synaptic Transmission | 1977 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic | 1979 |
Effect of centrally active drugs on dopamine oxidation by rat brain catecholamine oxidase.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Desipramine; Dopamine; Dopamine beta-Hydroxylase; Female; Haloperidol; Imipramine; Kinetics; Promazine; Rats; Thioridazine; Trifluoperazine; Trifluperidol | 1979 |
Tricyclic antidepressant drugs as antagonists of muscarinic receptors in sympathetic ganglia.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Antidepressive Agents, Tricyclic; Cats; Clomipramine; Desipramine; Dimethylphenylpiperazinium Iodide; Ganglia, Autonomic; Ganglia, Spinal; Imipramine; Iprindole; Nictitating Membrane; Norepinephrine; Receptors, Cholinergic; Receptors, Muscarinic; Serotonin; Viloxazine | 1976 |
The effect of tricyclic antidepressants on corticofugal inhibition of the spinal trigeminal nucleus.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brompheniramine; Cats; Cerebral Cortex; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Drug Combinations; Imipramine; Neural Inhibition; Procyclidine; Spinal Cord; Trigeminal Nerve | 1977 |
[Hepatic allopurinol oxidizing enzyme in mice].
Topics: Aldehyde Oxidoreductases; Allopurinol; Animals; Chlorpromazine; Desipramine; Dexamethasone; Dialysis; Diphenhydramine; Hot Temperature; Imipramine; Ions; Liver; Male; Mice; Niacinamide; Oxypurinol; Testosterone; Time Factors; Vitamin K; Xanthine Oxidase | 1975 |
Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking Behavior; Fenclonine; Imipramine; Male; Methyltyrosines; Nortriptyline; Protriptyline; Rats; Water Deprivation | 1977 |
Properties of thiamine di- and triphosphatases in rat brain microsomes: effects of chlorpromazine.
Topics: Acetone; Animals; Brain; Calcium; Chlorpromazine; Deoxycholic Acid; Desipramine; Imipramine; Kinetics; Magnesium; Male; Microsomes; Organophosphorus Compounds; Phosphoric Diester Hydrolases; Pyrophosphatases; Rats; Thiamine; Thiamine Pyrophosphatase | 1975 |
Regulation of prostaglandin metabolism: activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugs.
Topics: Alcohol Oxidoreductases; Amitriptyline; Animals; Chlorpromazine; Desipramine; Dibenzocycloheptenes; Enzyme Activation; Hydroxyprostaglandin Dehydrogenases; Imipramine; Kidney; Kinetics; NAD; Protriptyline; Swine | 1976 |
Determination of chloroimipramine and its demethyl metabolite in plasma by ion-pair partition chromatography.
Topics: Alkanes; Butanols; Chromatography, Ion Exchange; Clomipramine; Desipramine; Dibenzazepines; Humans; Imipramine; Mesylates; Methyl Chloride | 1976 |
Effect of thyrotropin-releasing hormone (TRH) and antidepressant agents on brain stem and hypothalamic multiple unit activity in the cat.
Topics: Animals; Antidepressive Agents, Tricyclic; Cats; Desipramine; Electrophysiology; Female; Hypothalamus; Hypothalamus, Anterior; Hypothalamus, Posterior; Imipramine; Male; Reticular Formation; Sleep, REM; Thyrotropin-Releasing Hormone | 1976 |
Enhancement of central norepinephrine and 5-hydroxytryptamine transmission by tricyclic antidepressants. A comparison.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cats; Clomipramine; Desipramine; Electric Stimulation; Female; Imipramine; Male; Norepinephrine; Serotonin; Stimulation, Chemical; Sympathetic Nervous System; Synaptic Transmission; Time Factors | 1979 |
Growth of hyperkinetic children taking methylphenidate, dextroamphetamine, or imipramine/desipramine.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Desipramine; Dextroamphetamine; Growth; Humans; Imipramine; Male; Methylphenidate | 1978 |
Effects of 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds, potential antidepressants, on biogenic amine uptake mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Biogenic Amines; Brain Chemistry; Carbazoles; Desipramine; Dopamine; Imipramine; In Vitro Techniques; Mice; Myocardium; Neurons; Norepinephrine; Phenethylamines; Serotonin; Structure-Activity Relationship | 1977 |
Effects of drugs on hyperactivity and aggression induced by raphe lesions in rats.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Atropine; Brain Stem; Clomipramine; Desipramine; Humans; Imipramine; Male; Methyltyrosines; Motor Activity; Raphe Nuclei; Rats | 1978 |
Steady-state kinetics of imipramine in patients.
Topics: Adult; Desipramine; Female; Humans; Imipramine; Kinetics; Male; Middle Aged | 1977 |
Metabolism of 5-hydroxytryptamine and levels of tricyclic antidepressant drugs in rat brain after acute and chronic treatment.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Desipramine; Drug Administration Schedule; Imipramine; Male; Probenecid; Protriptyline; Rats; Serotonin | 1977 |
Excretion of imipramine and desipramine in human breast milk.
Topics: Adult; Breast Feeding; Desipramine; Female; Humans; Imipramine; Milk, Human | 1979 |
Inhibition of neuronal uptake of 3H-biogenic amines into rat cerebral cortex by partially and fully saturated derivatives of imipramine and desipramine. The importance of the aromatic ring in adrenergic amines--part 3.
Topics: Animals; Biogenic Amines; Cerebral Cortex; Desipramine; Dopamine; Imipramine; In Vitro Techniques; Kinetics; Male; Molecular Conformation; Neurons; Norepinephrine; Rats; Serotonin; Structure-Activity Relationship | 1979 |
High-affinity 3H-imipramine binding in rat cerebral cortex.
Topics: Amitriptyline; Animals; Binding Sites; Cerebral Cortex; Clomipramine; Desipramine; Imipramine; In Vitro Techniques; Male; Rats | 1979 |
Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data.
Topics: Depression; Desipramine; Drug Administration Schedule; Female; Humans; Imipramine; Kinetics; Male; Models, Biological | 1979 |
Release of 3H-noradrenaline from the rat vas deferens under various in vitro conditions.
Topics: Aminobenzoates; Amphetamine; Anesthetics, Local; Animals; Calcium; Choline; Desipramine; Dose-Response Relationship, Drug; Imipramine; Male; Morphine; Norepinephrine; Potassium; Rats; Reserpine; Sodium; Vas Deferens; Veratridine | 1979 |
Effects of triiodothyronine on drug levels and cardiac function in depressed patients treated with imipramine.
Topics: Adult; Depression; Desipramine; Female; Heart Conduction System; Heart Rate; Humans; Imipramine; Middle Aged; Ovum; Triiodothyronine | 1979 |
High-performance liquid chromatographic assay for imipramine, desipramine, and their 2-hydroxylated metabolites.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Humans; Hydroxylation; Imipramine; Mass Spectrometry; Methods | 1979 |
Characteristics of the therapeutic response to imipramine in hyperactive children.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Desipramine; Drug Tolerance; Erythrocytes; Humans; Hyperkinesis; Imipramine | 1979 |
A sensitive method for the simultaneous determination in biological fluids of imipramine and desipramine or clomipramine and N-desmethylclomipramine by gas chromatography mass spectrometry.
Topics: Chromatography, Gas; Clomipramine; Dealkylation; Desipramine; Humans; Imipramine; Mass Spectrometry; Methods | 1979 |
Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity.
Topics: Animals; Antidepressive Agents, Tricyclic; Biotransformation; Cerebral Cortex; Clomipramine; Desipramine; Hydroxylation; Imipramine; Male; Motor Activity; Norepinephrine; Rats; Reserpine; Serotonin; Synaptosomes; Tissue Distribution | 1979 |
The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bundle-Branch Block; Depression; Desipramine; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Imipramine; Male; Middle Aged | 1979 |
Electrocortical changes in the encéphale isolé cat following chronic treatment with antidepressant drugs.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Antidepressive Agents; Cats; Decerebrate State; Desipramine; Electroencephalography; Female; Imipramine; Male; Viloxazine | 1979 |
Quantification of imipramine and desipramine in plasma by high-performance liquid chromatography and fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine | 1979 |
Plasma levels of imipramine (IMI) and desmethylimipramine (DMI) and clinical response in prepubertal major depressive disorder: a preliminary report.
Topics: Child; Depression; Desipramine; Female; Humans; Imipramine; Male | 1979 |
Guidelines for therapeutic monitoring of tricyclic antidepressant plasma levels.
Topics: Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Drug Interactions; Humans; Imipramine; Monitoring, Physiologic | 1979 |
Clinical utility of tricyclic antidepressant blood levels: a case report.
Topics: Aged; Aging; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Phenothiazines | 1979 |
Tricyclic antidepressant overdose: incidence of symptoms.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Electrocardiography; Heart; Humans; Imipramine; Nortriptyline | 1977 |
The kinetics of imipramine-N-oxide in man.
Topics: Administration, Oral; Adult; Biological Availability; Depression; Desipramine; Drug Evaluation; Female; Half-Life; Humans; Imipramine; Injections, Intramuscular; Injections, Intravenous; Male; Species Specificity; Time Factors | 1978 |
Plasma levels of tricyclic antidepressants and clinical efficacy: review of the literature -- part II.
Topics: Antidepressive Agents, Tricyclic; Biotransformation; Clomipramine; Depression; Desipramine; Dibenzocycloheptenes; Dose-Response Relationship, Drug; Doxepin; Drug Interactions; Humans; Imipramine; Maprotiline; Protriptyline | 1979 |
Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amitriptyline; Animals; Brain Chemistry; Catechols; Depression, Chemical; Desipramine; Dopamine; Ethylene Glycols; Glycols; Homovanillic Acid; Imipramine; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Time Factors; Tyrosine | 1977 |
The electroencephalographic and psychological effects of imipramine in depressed inpatients.
Topics: Adult; Depression; Desipramine; Electroencephalography; Female; Humans; Imipramine; Male; Middle Aged; Motor Skills; Psychiatric Status Rating Scales; Reaction Time; Time Factors | 1977 |
A simple method for the determination of therapeutic levels of clomipramine, imipramine and desipramine.
Topics: Chromatography, Thin Layer; Clomipramine; Desipramine; Dibenzazepines; Humans; Imipramine | 1977 |
Liquid-chromatographic procedure for tricyclic drugs and their metabolites in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Humans; Imipramine; Nortriptyline | 1978 |
Radioimmunoassay of imipramine and desmethylimipramine.
Topics: Antibody Specificity; Desipramine; Humans; Imipramine; Radioimmunoassay | 1978 |
Determination of drugs in plasma by high-performance thin-layer chromatography.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Desipramine; Humans; Imipramine; Nortriptyline; Phenobarbital; Phenytoin; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1978 |
Imipramine and desipramine plasma levels: relationship to dosage schedule and sampling time.
Topics: Adult; Blood Specimen Collection; Depression; Desipramine; Drug Administration Schedule; Female; Half-Life; Humans; Imipramine; Male; Middle Aged | 1978 |
Plasma imipramine and desmethylimipramine concentration and clinical response in childhood enuresis.
Topics: Child; Desipramine; Enuresis; Humans; Imipramine; Male; Placebos; Scopolamine Derivatives | 1978 |
Tricyclic antidepressants: plasma levels and clinical findings in overdose.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Electrocardiography; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1978 |
High-performance liquid-chromatographic simultaneous determination of commonly used tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline | 1978 |
ECG changes in pure impramine overdose as function of plasma level.
Topics: Adult; Desipramine; Electrocardiography; Female; Heart; Heart Arrest; Heart Conduction System; Humans; Imipramine; Seizures; Time Factors | 1978 |
Separation and quantitative determination of imipramine and desipramine from rat biological samples by high pressure liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Desipramine; Imipramine; Male; Rats; Tissue Distribution | 1978 |
Plasma level monitoring of tricyclic antidepressants: methodological and pharmacokinetic considerations.
Topics: Antidepressive Agents, Tricyclic; Blood Proteins; Dealkylation; Desipramine; Humans; Hydroxylation; Imipramine; Kinetics; Methods; Protein Binding; Time Factors | 1978 |
Studies on plasma level/effect relationships in imipramine therapy.
Topics: Depression; Desipramine; Humans; Imipramine; Kinetics; Methods | 1978 |
Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain.
Topics: Animals; Biogenic Amines; Brain; Desipramine; Dopamine; Imipramine; In Vitro Techniques; Kinetics; Male; Motor Activity; Norepinephrine; Rats; Serotonin; Synaptosomes | 1979 |
Tricyclic antidepressant overdoses in adolescent patients.
Topics: Adolescent; Affective Symptoms; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Imipramine; Male; Substance-Related Disorders; Suicide, Attempted | 1977 |
Clinical implications of imipramine plasma levels for depressive illness.
Topics: Bipolar Disorder; Delusions; Depression; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Individuality; Male; Middle Aged; Sex Factors | 1977 |
Tricyclic antidepressant drugs: attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents, Tricyclic; Brain Chemistry; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Imipramine; Lysergic Acid Diethylamide; Male; Methyltyrosines; Rats; Reflex, Startle; Time Factors | 1977 |
Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogs.
Topics: Animals; Antidepressive Agents, Tricyclic; Cardiac Output; Clomipramine; Desipramine; Dogs; Heart Rate; Hemodynamics; Imipramine; In Vitro Techniques; Myocardial Contraction; Time Factors | 1977 |
Relationship between age and tricyclic antidepressant plasma levels.
Topics: Administration, Oral; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Depression; Desipramine; Female; Half-Life; Heart; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1977 |
Effects of 5HT uptake inhibitors on the pressor response to 5HT in the pithed rat. The significance of the 5HT blocking property.
Topics: Animals; Anisoles; Blood Pressure; Chlorpheniramine; Desipramine; Drug Synergism; Imipramine; Male; Muscle Contraction; Piperidines; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes | 1977 |
Variance analysis of error in selected ion monitoring assays using various internal standards. A practical study case.
Topics: Analysis of Variance; Chromatography, Gas; Desipramine; Imipramine; Maprotiline; Mass Spectrometry; Methods; Promazine; Regression Analysis; Time Factors | 1977 |
Effects of tricyclic antidepressants on the content and metabolism of dopamine in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Benztropine; Corpus Striatum; Desipramine; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Imipramine; Male; Rats; Time Factors | 1977 |
Impurities in drugs I: Imipramine, desipramine, and their formulations.
Topics: Capsules; Chemistry, Pharmaceutical; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Drug Contamination; Imipramine; Tablets | 1977 |
A case of fatal imipramine poisoning in an infant.
Topics: Desipramine; Humans; Imipramine; Infant; Liver | 1977 |
High-performance thin-layer chromatographic determination of psychopharmacologic agents in blood serum.
Topics: Amitriptyline; Chlorpromazine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Desipramine; Humans; Imipramine; Methods; Nortriptyline; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1977 |
Alterations induced in distribution and in vivo metabolism of imipramine by pregnenolone-16alpha-carbonitrile.
Topics: Animals; Blood Proteins; Brain Chemistry; Chromatography, Gas; Desipramine; Drug Interactions; Female; Imipramine; Pregnenolone Carbonitrile; Protein Binding; Rats; Time Factors | 1977 |
Ion-pair partition chromatography in the analysis of drugs and biogenic substances in plasma and urine.
Topics: Absorption; Biogenic Amines; Chromatography, Ion Exchange; Chromatography, Liquid; Desipramine; Humans; Hydroxylation; Imipramine; Indoleacetic Acids; Metanephrine; Normetanephrine; Quinidine; Spectrophotometry, Ultraviolet | 1976 |
Effects of 4-methyl-alpha-ethyl-tyramine, 4, alpha-dimethyl-tyramine and tetrabenazine on the release and uptake of 5-hydroxytryptamine by human blood platelets in vitro.
Topics: Blood Platelets; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; In Vitro Techniques; Serotonin; Temperature; Tetrabenazine; Time Factors; Tyramine | 1976 |
Treatment of experimental imipramine and desipramine poisoning in the rat.
Topics: Adsorption; Animals; Antidotes; Bile; Charcoal; Desipramine; Digestive System; Enterohepatic Circulation; Female; Imipramine; Injections, Intraperitoneal; Kinetics; Rats | 1976 |
Active transport of 3H-bretylium in the rat vas deferens in vitro.
Topics: Aminobenzoates; Amphetamine; Anesthetics, Local; Animals; Biological Transport, Active; Bretylium Compounds; Chlorides; Cocaine; Desipramine; Hydroxybenzoate Ethers; Hydroxydopamines; Imipramine; Lidocaine; Male; meta-Aminobenzoates; Ouabain; Rats; Reserpine; Sodium; Sympathetic Nervous System; Temperature; Vas Deferens | 1976 |
Correlation between plasma and cerebrospinal levels of imipramine.
Topics: Depression; Desipramine; Humans; Imipramine | 1976 |
Measurement of plasma levels of tricylic psychoactive drugs and their metabolites by UV reflectance photometry of thin layer chromatograms.
Topics: Amitriptyline; Chromatography, Thin Layer; Clozapine; Desipramine; Humans; Imipramine; Methods; Nortriptyline; Perazine; Psychotropic Drugs; Spectrophotometry, Ultraviolet | 1976 |
Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities.
Topics: Amitriptyline; Animals; Apomorphine; Biogenic Amines; Brain; Desipramine; Drug Synergism; Gastric Juice; Imipramine; In Vitro Techniques; Levodopa; Mice; Morpholines; Myocardium; Norepinephrine; Oxotremorine; Pupil; Rats; Reflex; Reserpine; Serotonin; Tyramine; Viloxazine | 1976 |
Gas-chromatographic analysis for therapeutic concentration of imipramine and disipramine in plasma, with use of a nitrogen detector.
Topics: Chromatography, Gas; Desipramine; Evaluation Studies as Topic; Humans; Imipramine; Indicators and Reagents; Microchemistry; Nitrogen | 1976 |
Effects of short-and long-term administration of tricyclic antidepressants and lithium on norepinephrine turnover in brain.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Desipramine; Humans; Imipramine; Lithium; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Time Factors | 1976 |
[Psychotropic drugs and glaucoma (author's transl)].
Topics: Adult; Aged; Clomipramine; Depression; Desipramine; Dibenzocycloheptenes; Female; Fluphenazine; Glaucoma; Humans; Imipramine; Intraocular Pressure; Male; Middle Aged; Opipramol; Perazine; Psychotropic Drugs; Thiothixene; Tonometry, Ocular | 1976 |
Simultaneous measurement of imipramine and desipramine by selected ion recording with deuterated internal standards.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Desipramine; Deuterium; Humans; Imipramine; Mass Spectrometry; Methods | 1976 |
The separation of some tricyclic antidepressants by high-performance liquid chromatography.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Imipramine; Microchemistry; Nortriptyline; Protriptyline; Trimipramine | 1976 |
Plasma levels of imipramine in depression. Environmental and genetic factors.
Topics: Adult; Binding Sites; Biological Availability; Depression; Desipramine; Humans; Hydroxylation; Imipramine; Microsomes, Liver; Molecular Biology; Oxygenases; Schizophrenia; Smoking | 1976 |
On the anticataleptic action of cyproheptadine.
Topics: Animals; Atropine; Catalepsy; Clomipramine; Cyproheptadine; Desipramine; Female; Fluphenazine; Humans; Imipramine; Male; Methyltyrosines; Pilocarpine; Pimozide; Promethazine; Rats; Reserpine; Spiperone | 1976 |
The effect of amitriptyline, desipramine and imipramine on the vivo brain synthesis of 3H-noradrenaline from 3H-L-dopa in the rat.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Benserazide; Brain; Chromatography, Thin Layer; Desipramine; Dopamine; Imipramine; Levodopa; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Normetanephrine; Rats; Tryptamines | 1975 |
Patterns of symptom change in anxious depressed outpatients treated with different drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipramine; Diazepam; Drug Combinations; Fluphenazine; Humans; Imipramine; Mental Disorders; Nortriptyline; Perphenazine; Thioridazine; Thiothixene; Tranquilizing Agents; Trifluoperazine | 1975 |
Further studies on the effect of imipramine and desipramine on uridine diphosphate.
Topics: Amidinotransferases; Animals; Bilirubin; Desipramine; Dose-Response Relationship, Drug; Enzyme Activation; Imipramine; In Vitro Techniques; Microsomes, Liver; Rats | 1975 |
Uptake of noradrenaline by an adrenergic clone of neuroblastoma cells.
Topics: Amphetamine; Clone Cells; Desipramine; Imipramine; Kinetics; Neuroblastoma; Norepinephrine; Ouabain | 1975 |
The effect of tricyclic antidepressants on cholinergic responses of single cortical neurones.
Topics: Acetylcholine; Action Potentials; Animals; Antidepressive Agents; Atropine; Carbachol; Cats; Cerebral Cortex; Desipramine; Female; Imipramine; In Vitro Techniques; Male; Neurons; Norepinephrine; Parasympathetic Nervous System; Serotonin | 1975 |
First-pass metabolism of imipramine in man.
Topics: Administration, Oral; Adult; Biological Availability; Desipramine; Female; Glucuronates; Half-Life; Humans; Imipramine; Injections, Intravenous; Liver Circulation; Male; Methylation; Middle Aged; Time Factors | 1975 |
[Antimitotic activity of some derivatives of imipramine].
Topics: Cells, Cultured; Clomipramine; Desipramine; Dibenzazepines; Humans; Imipramine; Lectins; Lymphocytes; Mitosis | 1975 |
The interaction between alpha-methyl-dopa and tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cats; Desipramine; Drug Interactions; Female; Imipramine; Male; Methyldopa | 1975 |
Cardiovascular side effects of tricyclic antidepressants - a risk in the use of these drugs.
Topics: Acridines; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Cats; Desipramine; Heart; Hemodynamics; Imipramine; Myocardial Contraction; Norepinephrine; Papillary Muscles | 1975 |
Interactions of tricyclic antidepressants and barbiturates in barbiturate-tolerant and nontolerant rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Barbiturates; Brain Chemistry; Desipramine; Drug Interactions; Drug Tolerance; Imipramine; Male; Microsomes, Liver; Nortriptyline; Pentobarbital; Rats; Sleep; Time Factors | 1975 |
[Plasma levels of imipramine and desmethylimipramine and antidepressant effect during controlled therapy(author's transl)].
Topics: Adjustment Disorders; Aged; Desipramine; Drug Interactions; Drug Synergism; Humans; Imipramine; Methotrimeprazine; Middle Aged; Time Factors | 1975 |
On the origin of desmethyl imipramine in rat brain.
Topics: Animals; Brain; Desipramine; Imipramine; In Vitro Techniques; Liver; Male; Rats | 1975 |
Norepinephrine metabolism after short- and long-term administration of tricyclic antidepressant drugs and electroconvulsive shock.
Topics: Animals; Antidepressive Agents, Tricyclic; Depression, Chemical; Desipramine; Electroshock; Imipramine; Norepinephrine; Protriptyline; Rats; Time Factors | 1975 |
Gas chromatographic-mass fragmentographic determation of "steady-state" plasma levels of imipramine and desipramine in chronically treated patients.
Topics: Chromatography, Gas; Depression; Desipramine; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Middle Aged; Promazine | 1975 |
Uptake and release of 3H-metaraminol by rat lung. The influence of various drugs.
Topics: Animals; Cocaine; Desipramine; Female; Imipramine; In Vitro Techniques; Lung; Metaraminol; Ouabain; Rats; Reserpine; Time Factors; Tyramine | 1975 |
Inhibition of prostaglandin synthetase by psychotropic drugs.
Topics: Amitriptyline; Animals; Anthracenes; Antidepressive Agents; Arachidonic Acids; Cattle; Chlorpromazine; Clomipramine; Desipramine; Enzyme Inhibitors; Haloperidol; Imipramine; Male; Mixed Function Oxygenases; Prostaglandins; Psychotropic Drugs; Seminal Vesicles | 1975 |
Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depression, Chemical; Desipramine; Humans; Hypothalamus; Imipramine; Male; Mesencephalon; Norepinephrine; Serotonin; Synaptosomes; Time Factors | 1975 |
Tricyclic antidepressant agents. II. Effect of oral administration on the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices of the midbrain-hypothalamus region of the rat.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biotransformation; Desipramine; Hypothalamus; Imipramine; Male; Mesencephalon; Norepinephrine; Proadifen; Rats; Serotonin; Time Factors | 1975 |
[Effect of prothixen and related compounds on serotonin absorption by human thrombocytes].
Topics: Absorption; Amitriptyline; Biological Transport; Blood Platelets; Cell Membrane Permeability; Chlorpromazine; Clomipramine; Depression, Chemical; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Serotonin; Structure-Activity Relationship; Thioxanthenes; Triazines | 1975 |
Development of the influences of sodium, catecholamine and tricyclic antidepressent drug on the uptake of [3H]5-hydroxytryptamine by rat brain synaptosomes.
Topics: Age Factors; Animals; Antidepressive Agents, Tricyclic; Biological Transport, Active; Brain; Catecholamines; Depression, Chemical; Desipramine; Dopamine; Female; Imipramine; Male; Norepinephrine; Ouabain; Rats; Serotonin; Sodium; Synaptosomes; Temperature | 1975 |
Biogenic amines and depression. Biochemical and pharmacological separation of two types of depression.
Topics: Amitriptyline; Biogenic Amines; Depression; Desipramine; Dextroamphetamine; Humans; Hydroxyindoleacetic Acid; Imipramine; Metanephrine; Methoxyhydroxyphenylglycol; Normetanephrine; Nortriptyline; Vanilmandelic Acid | 1975 |
Antagonism of antihypertensive effect of clonidine by imipramine & desmethylimipramine in renal hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Desipramine; Hypertension, Renal; Imipramine; Rats | 1975 |
[Electrocardiographic changes in acute poisoning by tricyclic drugs].
Topics: Accidents, Home; Adolescent; Arrhythmias, Cardiac; Child, Preschool; Desipramine; Electrocardiography; Female; Heart Conduction System; Humans; Imipramine; Male; Suicide, Attempted | 1975 |
Effects of perphenazine on imipramine metabolism in man.
Topics: Adult; Desipramine; Drug Interactions; Female; Glucuronates; Humans; Imipramine; Male; Middle Aged; Perphenazine; Schizophrenia; Time Factors | 1975 |
A sensitive GLC method for the determination of imipramine and desmethylimipramine using a nitrogen detector.
Topics: Chromatography, Gas; Desipramine; Humans; Hydroxylation; Imipramine; Methods; Nitrogen; Time Factors | 1975 |
[Postsynaptic attack of tricyclic antidepressive agents in the circulatory system].
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Female; Heart; Hemodynamics; Imipramine; Male; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Rats; Receptors, Drug | 1975 |
[Proceedings: Effect of tricyclic antidepressive agents and of Nomifensin (Hoe984) on the contractile properties of the isolated papillary muscle and on the tonus of the smooth vascular muscles].
Topics: Acridines; Animals; Anthracenes; Antidepressive Agents, Tricyclic; Cats; Desipramine; Imipramine; Isoquinolines; Maprotiline; Muscle Contraction; Muscle, Smooth; Papillary Muscles; Rats | 1975 |
The effects of some pharmacologically active amines on the rate of gastric emptying in rats.
Topics: Animals; Depression, Chemical; Desipramine; Dextroamphetamine; Imipramine; Male; Nortriptyline; Parasympatholytics; Rats; Rats, Inbred Strains; Stomach; Structure-Activity Relationship | 1976 |
Centrally-acting drugs and related compounds examined for action on output of adenine derivatives from superfused tissues of the brain.
Topics: Adenine; Adenine Nucleotides; Amobarbital; Animals; Brain; Chlorpromazine; Desipramine; Guinea Pigs; Imipramine; In Vitro Techniques; Lactates; Phenytoin; Psychotropic Drugs | 1976 |
Intestinal absorption, demethylation, and enterohepatic circulation of imipramine.
Topics: Dealkylation; Desipramine; Enterohepatic Circulation; Female; Humans; Imipramine; Intestinal Absorption; Liver; Male; Middle Aged; Time Factors | 1976 |
Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Brain; Clomipramine; Desipramine; Fenclonine; Imipramine; Male; Mice; Mice, Inbred ICR; Morphine; Norepinephrine; Phenoxybenzamine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Reserpine; Serotonin | 1992 |
Effect of antidepressant drugs on monoamine synthesis in brain in vivo.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Citalopram; Clorgyline; Cyclopropanes; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Haloperidol; Hydrazines; Imipramine; Male; Milnacipran; Norepinephrine; Organ Specificity; Parietal Lobe; Rats; Rats, Wistar; Serotonin; Tyrosine 3-Monooxygenase | 1992 |
A comparative study on desipramine pharmacokinetics in the rat brain after administration of desipramine or imipramine.
Topics: Administration, Oral; Animals; Brain; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Models, Biological; Rats; Rats, Wistar; Spectrometry, Fluorescence | 1992 |
Interaction between fluvoxamine and imipramine/desipramine in four patients.
Topics: Depressive Disorder; Desipramine; Drug Interactions; Female; Fluvoxamine; Humans; Imipramine; Male; Middle Aged | 1992 |
Growth deficits and desipramine.
Topics: Appetite; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Depressive Disorder; Desipramine; Humans; Imipramine | 1992 |
Population pharmacokinetics of imipramine in children.
Topics: Adolescent; Algorithms; Child; Demography; Desipramine; Female; Hospitals, University; Humans; Imipramine; Male; Models, Biological; Spain | 1992 |
Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction.
Topics: Adult; Desipramine; Drug Evaluation; Drug Interactions; Fluoxetine; Humans; Imipramine; Male; Middle Aged | 1992 |
Dosage optimization methods applied to imipramine and desipramine in enuresis treatment.
Topics: Adolescent; Algorithms; Child; Child, Preschool; Desipramine; Drug Administration Schedule; Enuresis; Female; Humans; Imipramine; Male | 1992 |
Effects of chronic variable stress and antidepressant drugs on behavioral inactivity during an uncontrollable stress: interaction between both treatments.
Topics: Animals; Antidepressive Agents; Arousal; Clomipramine; Desipramine; Escape Reaction; Helplessness, Learned; Imipramine; Motor Activity; Phenelzine; Rats; Stress, Psychological | 1992 |
Persistent impairment of clomipramine demethylation in recently detoxified alcoholic patients.
Topics: Adult; Alcoholism; Clomipramine; Dealkylation; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged; Models, Biological | 1992 |
Tricyclic antidepressant-induced seizures and plasma drug concentration.
Topics: Adult; Ambulatory Care; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Monitoring; Epilepsy, Tonic-Clonic; Female; Hospitalization; Humans; Imipramine; Incidence; Male; Middle Aged; Panic Disorder | 1992 |
Inhibition and metabolite complexation of rat hepatic microsomal cytochrome P450 by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Hydroxylation; Imipramine; Male; Microsomes, Liver; Nortriptyline; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Testosterone | 1992 |
Effects of the antidepressant/antipanic drug phenelzine on GABA concentrations and GABA-transaminase activity in rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Antidepressive Agents; Brain; Desipramine; Dose-Response Relationship, Drug; Frontal Lobe; gamma-Aminobutyric Acid; Imipramine; Male; Panic; Phenelzine; Rats; Rats, Inbred Strains; Tranylcypromine | 1992 |
Immobility-reducing effects of antidepressants in a genetic animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Depression, Chemical; Desipramine; Disease Models, Animal; Imipramine; Isoflurophate; Motor Activity; Rats; Rats, Inbred Strains; Swimming | 1992 |
Ischemic colitis associated with psychotropic drugs.
Topics: Adult; Chlorpromazine; Colitis; Colon; Desipramine; Female; Humans; Imipramine; Ischemia | 1992 |
Beta-adrenoceptors and antidepressants: possible 2-phenylethylamine mediation of chronic phenelzine effects.
Topics: Albuterol; Animals; Antidepressive Agents; Arousal; Brain; Desipramine; Dose-Response Relationship, Drug; Imipramine; Liver; Male; Monoamine Oxidase; Motor Activity; Norepinephrine; Phenelzine; Phenethylamines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Tranylcypromine | 1991 |
Effect of some cationic amphiphilic drugs on phospholipid methylation in the central nervous system of rats.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Citalopram; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Methylation; Methyltransferases; Phospholipids; Rats; Rats, Inbred Strains; Synaptic Membranes | 1991 |
Regional distribution of imipramine, desipramine and specific [3H]desipramine binding sites in the rat brain after acute and chronic treatment with imipramine.
Topics: Animals; Binding Sites; Brain; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Chromatography, High Pressure Liquid; Desipramine; Drug Resistance; Erythrocytes; Female; Imipramine; Malaria; Mice; Mice, Inbred ICR; Plasmodium chabaudi; Trifluoperazine | 1992 |
Pseudodepression in hyponatremia.
Topics: Aged; Depressive Disorder; Desipramine; Humans; Hyponatremia; Imipramine; Male | 1991 |
The tail suspension test for screening antidepressant drugs: comparison of movement in ICR and NMRI mice.
Topics: Animals; Antidepressive Agents; Arousal; Desipramine; Drug Evaluation, Preclinical; Imipramine; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Motivation; Motor Activity; Species Specificity | 1991 |
Analgesia by nefopam: does it act through serotonin?
Topics: Analgesia; Blood Platelets; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Morphine; Nefopam; Orphenadrine; Serotonin Antagonists | 1991 |
Chronopharmacokinetics of imipramine and desipramine in rat forebrain and plasma after single and chronic treatment with imipramine.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Desipramine; Dose-Response Relationship, Drug; Imipramine; Light; Male; Prosencephalon; Rats; Rats, Inbred Strains | 1991 |
Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain.
Topics: Amygdala; Animals; Antidepressive Agents; Blotting, Northern; Brain; Brain Chemistry; Desipramine; Female; Hippocampus; Hypothalamo-Hypophyseal System; Hypothalamus; Imipramine; Ketanserin; Lithium; Male; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; RNA, Messenger; Sex Characteristics; Up-Regulation | 1991 |
Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice.
Topics: Amitriptyline; Animals; Desipramine; Dose-Response Relationship, Drug; Electroshock; Imipramine; Male; Mice; Seizures; Valproic Acid | 1991 |
Determination of imipramine, desipramine and their hydroxy metabolites by reversed-phase chromatography with ultraviolet and coulometric detection.
Topics: Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Humans; Imipramine; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Methylated and demethylated tricyclic antidepressants and their binding to cell membranes.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Cattle; Cell Membrane; Dealkylation; Desipramine; Erythrocyte Membrane; Imipramine; In Vitro Techniques; Lymphocytes; Methylation; Phosphatidylserines; Phospholipids; Synaptic Membranes | 1991 |
Changes of ligand binding after membrane phosphorylation.
Topics: Animals; Antidepressive Agents, Tricyclic; Cattle; Dealkylation; Desipramine; Dibenzazepines; Humans; Imipramine; In Vitro Techniques; Kinetics; Ligands; Phosphorylation; Synaptic Membranes | 1991 |
High-affinity [3H]6-nitroquipazine binding to the 5-hydroxytryptamine transport system in rat lung.
Topics: Animals; Biological Transport; Desipramine; Imipramine; Kinetics; Lung; Male; Maprotiline; Membranes; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Temperature; Tritium; Zimeldine | 1991 |
Platelet [3H]imipramine and alpha 2-adrenoceptor binding in normal subjects during desipramine administration and withdrawal.
Topics: Adult; Blood Platelets; Desipramine; Female; Humans; Imipramine; Kinetics; Male; Radioligand Assay; Receptors, Adrenergic, alpha; Reference Values; Time Factors | 1991 |
Drug-related alopecia in patients treated with tricyclic antidepressants.
Topics: Adult; Alopecia; Antidepressive Agents, Tricyclic; Anxiety Disorders; Child; Child Behavior Disorders; Desipramine; Female; Humans; Imipramine | 1991 |
Opposite effects of metoclopramide and propantheline on intestinal absorption of imipramine in rats.
Topics: Animals; Desipramine; Gastric Emptying; Imipramine; In Vitro Techniques; Intestinal Absorption; Liver; Male; Metoclopramide; Propantheline; Rats; Rats, Inbred Strains | 1991 |
Response of depression to very high plasma levels of imipramine plus desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Imipramine; Male; Psychiatric Status Rating Scales; Psychometrics | 1991 |
Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres.
Topics: Action Potentials; Animals; Antidepressive Agents; Calcium; Desipramine; Female; Guinea Pigs; Heart; Heart Atria; Heart Ventricles; Imipramine; In Vitro Techniques; Isoproterenol; Lofepramine; Male; Myocardial Contraction; Naphthalenes; Papillary Muscles; Refractory Period, Electrophysiological | 1991 |
Genotoxicity evaluation of five tricyclic antidepressants in the wing somatic mutation and recombination test in Drosophila melanogaster.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; DNA; Dose-Response Relationship, Drug; Drosophila melanogaster; Imipramine; Mutagenicity Tests; Nortriptyline; Protriptyline; Recombination, Genetic | 1991 |
Desipramine enhances isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; Clonidine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Activity; Phentolamine; Prazosin; Social Isolation; Yohimbine | 1991 |
Association of fluoxetine with suicidal ideation.
Topics: Depressive Disorder; Desipramine; Drug Therapy, Combination; Fluoxetine; Humans; Imipramine; Suicide | 1991 |
Carbon-13 nuclear magnetic resonance spectroscopy of lipids: differential line broadening due to cross-correlation effects as a probe of membrane structure.
Topics: Carbon Isotopes; Desipramine; Imipramine; Magnetic Resonance Spectroscopy; Membrane Lipids; Molecular Probes; Water | 1991 |
The cardiotoxicity of the tricyclics.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivity; Child; Death, Sudden; Depressive Disorder; Desipramine; Electrocardiography; Humans; Imipramine; Male | 1991 |
In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor.
Topics: Adrenergic alpha-Antagonists; Animals; Blepharoptosis; Brain; Clonidine; Conditioning, Operant; Desipramine; Drug Interactions; Imidazoles; Imipramine; Male; Mice; Norepinephrine; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Serotonin; Tetrabenazine | 1990 |
Evidence for feeding elicited through antihistaminergic effects of tricyclic antidepressants in the rat hypothalamus.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking; Eating; Histamine H1 Antagonists; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Methylhistidines; Microinjections; Rats; Rats, Inbred Strains; Zimeldine | 1990 |
The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.
Topics: Adult; Cytochrome P-450 Enzyme System; Desipramine; Female; Humans; Imipramine; Isoenzymes; Male; Mephenytoin; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1991 |
Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.
Topics: Animals; Behavior, Animal; Brain; Desipramine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Stereoisomerism; Swimming | 1991 |
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin.
Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine | 1991 |
Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: a comparison with imipramine.
Topics: Blood Platelets; Depressive Disorder; Desipramine; Humans; Imipramine; Psychiatric Status Rating Scales; Receptors, Serotonin; Serotonin | 1991 |
Autoradiographic analysis of the in vivo distribution of 3H-imipramine and 3H-desipramine in brain: comparison to in vitro binding patterns.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Stem; Desipramine; Diencephalon; Imipramine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Telencephalon; Tritium | 1991 |
[Antiprotozoal effects of benzodiazepine derivatives].
Topics: Animals; Benzodiazepines; Chlorpromazine; Clomipramine; Crithidia; Desipramine; Eukaryota; Imipramine; Leishmania mexicana; Metronidazole; Trichomonas vaginalis; Trypanosoma cruzi | 1990 |
Interaction between antidepressants and d-amphetamine on variable-interval performance.
Topics: Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Fluvoxamine; Imipramine; Oximes; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule; Serotonin Antagonists; Trazodone | 1990 |
Imipramine pharmacokinetics in depressed geriatric patients.
Topics: Adult; Age Factors; Aged; Chromatography, High Pressure Liquid; Depression; Desipramine; Female; Humans; Imipramine; Injections, Intramuscular; Male; Middle Aged; Time Factors | 1990 |
Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats.
Topics: Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Desipramine; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Hexobarbital; Imipramine; Isoenzymes; Lithium; Liver; Male; Metyrapone; Rats; Rats, Inbred Strains | 1990 |
Protracted ventricular arrhythmias occurring after abrupt tricyclic antidepressant withdrawal.
Topics: Depressive Disorder; Desipramine; Electrocardiography; Humans; Imipramine; Male; Middle Aged; Substance Withdrawal Syndrome; Tachycardia, Paroxysmal | 1990 |
The influence of clinical and pharmacological factors on enuresis treatment with imipramine.
Topics: Adolescent; Age Factors; Body Weight; Child; Child, Preschool; Desipramine; Enuresis; Female; Humans; Imipramine; Male; Regression Analysis; Time Factors | 1990 |
Use of maximal dentate activation to study the effect of drugs on kindling and kindled responses.
Topics: Animals; Carbamazepine; Desipramine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Imipramine; Kindling, Neurologic; Male; Molecular Structure; Rats; Rats, Inbred Strains | 1990 |
Tricyclic antidepressants, thyroid function, and their relationship with the behavioral responses in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arousal; Avoidance Learning; Clomipramine; Conditioning, Classical; Desipramine; Diabetes Mellitus, Experimental; Escape Reaction; Helplessness, Learned; Imipramine; Male; Rats; Rats, Inbred Strains; Thyroid Function Tests; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse | 1990 |
Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats.
Topics: Animals; Desipramine; Hydrogen-Ion Concentration; Imipramine; Injections, Intravenous; Male; Models, Biological; Phosphatidylserines; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Effect of posture on imipramine and desipramine plasma concentrations.
Topics: Adult; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Posture; Protein Binding | 1990 |
Nonlinear kinetics of imipramine in low and medium plasma level ranges.
Topics: Adult; Aged; Desipramine; Diabetic Neuropathies; Female; Half-Life; Homeostasis; Humans; Imipramine; Kinetics; Male; Middle Aged; Sparteine | 1990 |
Model for the kinetics of imipramine and its metabolites in adolescents.
Topics: Adolescent; Desipramine; Female; Humans; Imipramine; Male; Models, Biological; Models, Theoretical | 1990 |
Recurrent depression is associated with a persistent reduction in sleep-related growth hormone secretion.
Topics: Adult; Aged; Ambulatory Care; Biomarkers; Depressive Disorder; Desipramine; Electroencephalography; Female; Growth Hormone; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales; Recurrence; Sleep | 1990 |
Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Imipramine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1990 |
Vinpocetine therapy does not change imipramine pharmacokinetics in man.
Topics: Adult; Anticonvulsants; Blood Pressure; Desipramine; Drug Interactions; Heart Rate; Humans; Imipramine; Male; Vinca Alkaloids | 1990 |
Stable isotope coadministration methodology for the estimation of the fraction of imipramine metabolized to desipramine.
Topics: Adult; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Intestinal Absorption; Male | 1990 |
Concentration-response relationship in imipramine treatment of diabetic neuropathy symptoms.
Topics: Adult; Desipramine; Diabetic Neuropathies; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Middle Aged; Recurrence | 1990 |
Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats.
Topics: Animals; Desipramine; Imipramine; In Vitro Techniques; Infusions, Intravenous; Male; Microsomes, Liver; Models, Biological; Portal Vein; Rats; Rats, Inbred Strains | 1990 |
Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Amitriptyline; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Desipramine; Dibenzoxazepines; Enzyme Induction; Humans; Imipramine; Injections, Intraperitoneal; Male; Mianserin; Mice; Mice, Inbred CBA; Microsomes, Liver; Phenobarbital; Phenytoin | 1990 |
Picrotoxin changes the effects of imipramine and desipramine in rats in the forced swimming test.
Topics: Animals; Depressive Disorder; Desipramine; Drug Synergism; Imipramine; Male; Motor Activity; Picrotoxin; Rats; Rats, Inbred Strains; Swimming | 1990 |
Inhibition of fast axonal transport in bullfrog nerves by dibenzazepine and dibenzocycloheptadiene calmodulin inhibitors.
Topics: Acetylcholinesterase; Adenosine Triphosphate; Amitriptyline; Animals; Axonal Transport; Calmodulin; Clomipramine; Desipramine; Ganglia, Spinal; Imipramine; In Vitro Techniques; Microtubules; Phosphocreatine; Rana catesbeiana; Spinal Nerves | 1986 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminobutyric Acid; Imipramine; Ion Channels; Ionophores; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Correlative changes of serotonin and catecholamines with pharmacokinetic alterations of imipramine in rat brain.
Topics: Animals; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Effect of acute or chronic administration of imipramine on spinal and supraspinal micturition reflexes in rats.
Topics: Animals; Atropine; Desipramine; Enuresis; Fenclonine; Imipramine; Male; Rats; Receptors, Serotonin; Reflex; Spinal Cord; Urinary Bladder; Urination | 1989 |
Differences between sodium-dependent and desipramine-defined [3H]imipramine binding in intact human platelets.
Topics: Adult; Blood Platelets; Carrier Proteins; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Receptors, Drug; Receptors, Neurotransmitter; Sodium | 1989 |
Helpless behavior (escape deficits) in streptozotocin-diabetic rats: resistance to antidepressant drugs.
Topics: Animals; Antidepressive Agents; Brain; Clenbuterol; Clomipramine; Conditioning, Operant; Desipramine; Diabetes Mellitus, Experimental; Electroshock; Escape Reaction; Helplessness, Learned; Imipramine; Insulin; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Triiodothyronine | 1989 |
Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Brain; Desipramine; Diazepam; Imipramine; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Receptors, Serotonin | 1989 |
3H-imipramine binding in the frontal cortex of suicides.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Binding, Competitive; Carrier Proteins; Desipramine; Female; Frontal Lobe; Humans; Imipramine; Male; Middle Aged; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Suicide; Violence | 1989 |
Decreased GABA B receptors in helpless rats: reversal by tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Arousal; Brain; Desipramine; Escape Reaction; Frontal Lobe; Helplessness, Learned; Hippocampus; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1989 |
Chronic but not acute antidepressant treatment increases pentetrazol-induced convulsions in mice.
Topics: Animals; Antidepressive Agents; Desipramine; Drug Synergism; Imipramine; Male; Mice; Mice, Inbred Strains; Myoclonus; Pentylenetetrazole; Seizures | 1989 |
Modulation of arachidonate turnover in cerebral phospholipids.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cerebral Cortex; Desipramine; Imipramine; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Norepinephrine; Phospholipids; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Prediction of imipramine serum levels in enuretic children by a Bayesian method: comparison with two other conventional dosing methods.
Topics: Adolescent; Bayes Theorem; Child; Child, Preschool; Desipramine; Enuresis; Female; Humans; Imipramine; Male; Regression Analysis | 1989 |
Antagonism by tricyclic antidepressants of the muscarinic receptors located on the adrenergic nerve endings in rabbit heart atrium.
Topics: Animals; Antidepressive Agents, Tricyclic; Atropine; Desipramine; Electric Stimulation; Heart; Imipramine; Male; Norepinephrine; Nortriptyline; Oxotremorine; Parasympatholytics; Rabbits; Receptors, Muscarinic; Sympathetic Nervous System | 1989 |
Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.
Topics: Acute Disease; Desipramine; Electrocardiography; Emergencies; Female; Gastric Lavage; Humans; Imipramine; Infant; Medical History Taking; Seizures; Tachycardia | 1989 |
External quality assurance of tricyclic antidepressant measurements in serum: eight years of progress?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Nortriptyline; Quality Control | 1989 |
Predictive techniques applied to imipramine therapeutic drug monitoring.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Desipramine; False Positive Reactions; Female; Humans; Imipramine; Male; Middle Aged; Monitoring, Physiologic; Predictive Value of Tests | 1989 |
Plasma levels of imipramine and metabolites in 68 hospitalized children.
Topics: Adolescent; Child; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Psychiatric Department, Hospital | 1989 |
The safety of switching rapidly from tricyclic antidepressants to monoamine oxidase inhibitors.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Monoamine Oxidase Inhibitors; Phenelzine; Risk Factors; Tranylcypromine | 1989 |
Effect of tricyclic antidepressant drugs in the isolation-induced social behavioural deficit test.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Activity; Reference Values; Social Behavior; Social Isolation | 1989 |
Aggressive thoughts and behavior: another symptom of panic disorder?
Topics: Adult; Aggression; Combined Modality Therapy; Desipramine; Fear; Female; Humans; Imipramine; Male; Panic; Psychoanalytic Therapy; Suicide; Thinking; Violence | 1989 |
Hypersensitivity myocarditis and hepatitis associated with imipramine and its metabolite, desipramine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Desipramine; Drug Hypersensitivity; Female; Humans; Imipramine; Male; Middle Aged; Myocarditis | 1989 |
Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine.
Topics: Adult; Dealkylation; Desipramine; Drug Interactions; Female; Half-Life; Humans; Hydroxylation; Imipramine; Male; Phenotype; Quinidine; Sparteine | 1989 |
Effect of a protracted antidepressant treatment on signal transduction and [3H](-)-baclofen binding at GABAB receptors.
Topics: Adenylyl Cyclases; Animals; Anthracenes; Baclofen; Cerebral Cortex; Colforsin; Desipramine; Drug Administration Schedule; Imipramine; Injections, Intraperitoneal; Kinetics; Male; Maprotiline; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Chronic administration of tricyclic antidepressants suppresses hypothalamo-pituitary-adrenocortical activity in male rats.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Corticosterone; Desipramine; Dexamethasone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Imipramine; Male; Pituitary-Adrenal System; Rats; Rats, Inbred Strains | 1988 |
Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Cyclopentanes; Desipramine; Dose-Response Relationship, Drug; Female; Imipramine; Infusions, Intravenous; Iprindole; Kinetics; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Reference Values; Zimeldine | 1988 |
Assessment of rat brain alpha 1-adrenoceptor binding and activation of inositol phospholipid turnover following chronic imipramine treatment.
Topics: Animals; Cerebral Cortex; Desipramine; Imipramine; In Vitro Techniques; Inositol Phosphates; Iodocyanopindolol; Norepinephrine; Pindolol; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Sugar Phosphates | 1988 |
Impaired response of experimental diabetic mice to tricyclics: a possible beta-adrenergic mechanism.
Topics: Animals; Clenbuterol; Clomipramine; Desipramine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hypothermia, Induced; Imipramine; Male; Mice; Motor Activity; Receptors, Adrenergic, beta; Thyroxine; Triiodothyronine | 1988 |
[Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice].
Topics: Amnesia; Animals; Avoidance Learning; Carbon Dioxide; Central Nervous System Stimulants; Desipramine; Electroshock; Humans; Imipramine; Mice; Morpholines; Scopolamine | 1985 |
CSF somatostatin in affective illness and normal volunteers.
Topics: Bipolar Disorder; Carbamazepine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Lithium Carbonate; Somatostatin; Zimeldine | 1985 |
Effect of phenobarbitone on the distribution and elimination of imipramine in rats.
Topics: Animals; Desipramine; Half-Life; Imipramine; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Imipramine-flupenthixol decanoate interaction.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Desipramine; Drug Interactions; Flupenthixol; Humans; Imipramine; Male; Schizophrenia, Paranoid; Thioxanthenes; Trazodone | 1986 |
The effect of neuroleptics on imipramine demethylation in rat liver microsomes and imipramine and desipramine level in the rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Cytochrome P-450 Enzyme System; Dealkylation; Desipramine; Imipramine; Kinetics; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1986 |
Beta-adrenergic agonists reduce spontaneous motor activity through either beta 1 or beta 2 receptors.
Topics: Adrenergic beta-Agonists; Animals; Brain; Clenbuterol; Desipramine; Imipramine; Isoproterenol; Male; Mice; Motor Activity; Receptors, Adrenergic, beta | 1987 |
Drug interactions between imipramine and benzodiazepines in rats.
Topics: Animals; Anti-Anxiety Agents; Blood Proteins; Brain; Chromatography, High Pressure Liquid; Desipramine; Diazepam; Drug Interactions; Hypothermia; Imipramine; Liver; Male; Oxazepam; Protein Binding; Rats; Rats, Inbred Strains; Stress, Physiological | 1988 |
Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes.
Topics: Carrier Proteins; Cations, Monovalent; Desipramine; Female; Humans; Hydralazine; Imipramine; Kinetics; Microvilli; Placenta; Potassium Chloride; Pregnancy; Reserpine; Serotonin; Sodium Chloride | 1989 |
Effect of serotonin on the dissociation of high-affinity binding of [3H]imipramine in mouse cerebral cortex.
Topics: Animals; Blood Platelets; Cerebral Cortex; Desipramine; Drug Interactions; Imipramine; Male; Mice; Mice, Inbred BALB C; Serotonin; Zimeldine | 1986 |
Allergy to tartrazine in antidepressants.
Topics: Adult; Antidepressive Agents, Tricyclic; Azo Compounds; Desipramine; Drug Eruptions; Female; Humans; Imipramine; Mental Disorders; Pharmaceutic Aids; Tartrazine | 1987 |
Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment.
Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Zimeldine | 1988 |
Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice.
Topics: Animals; Atropine; Central Nervous System; Cimetidine; Depression; Desipramine; Disease Models, Animal; Histamine; Imidazoles; Imipramine; Impromidine; Male; Mice; Motor Activity; Pyrilamine; Receptors, Histamine H2 | 1988 |
Effect of chronic desmethylimipramine or electroconvulsive shock on selected brain and platelet neurotransmitter recognition sites.
Topics: Animals; Blood Platelets; Brain Chemistry; Carrier Proteins; Desipramine; Dihydroalprenolol; Electroshock; Imipramine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Drug; Receptors, Neurotransmitter | 1985 |
High- and low-affinity binding components for [3H]imipramine in rat cerebral cortex.
Topics: Animals; Binding Sites; Carrier Proteins; Cell Membrane; Cerebral Cortex; Desipramine; Imipramine; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, Neurotransmitter | 1985 |
5-Methoxytryptoline, a competitive endocoid acting at [3H]imipramine recognition sites in human platelets.
Topics: Binding, Competitive; Blood Platelets; Carbolines; Carrier Proteins; Desipramine; Humans; Imipramine; Indoles; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Tryptamines | 1985 |
Adaptive and differential changes on beta- and alpha 2-adrenoreceptors mediated hyperthermia after chronic treatment with antidepressant drugs in the rat kept at high ambient temperature.
Topics: Amitriptyline; Animals; Body Temperature; Brain; Desipramine; Environment; Hot Temperature; Hyperthermia, Induced; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1985 |
Effect of chronic desipramine treatment on dihydroalprenolol, imipramine, and desipramine binding sites: a quantitative autoradiographic study in the rat brain.
Topics: Alprenolol; Animals; Autoradiography; Binding Sites; Brain; Desipramine; Dihydroalprenolol; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Time Factors; Tissue Distribution | 1986 |
The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats.
Topics: Aging; Animals; Brain; Desipramine; Dihydroalprenolol; Imipramine; Indoles; Male; Pineal Gland; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Receptors, Serotonin | 1986 |
Chronic antidepressant treatment and mouse brain 3H-imipramine binding.
Topics: Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Desipramine; Haloperidol; Imipramine; Male; Mice; Mice, Inbred C57BL; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Dopamine D2; Selegiline | 1986 |
Repeated treatment with antidepressant drugs does not affect the benzodiazepine receptors in preincubated membrane preparations from mouse and rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Desipramine; Flunitrazepam; Imipramine; Male; Mice; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Results compared for tricyclic antidepressants as assayed by liquid chromatography and enzyme immunoassay.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Immunoenzyme Techniques; Nortriptyline | 1988 |
Mechanisms of extraneuronal serotonin uptake in the rat aorta.
Topics: Animals; Aorta; Cocaine; Cold Temperature; Corticosterone; Desipramine; Hydroxydopamines; Imipramine; Kinetics; Male; Neurons; Norepinephrine; Oxidopamine; Pargyline; Rats; Rats, Inbred Strains; Serotonin | 1986 |
Evolution of red blood cell membrane transport and plasma level of L-tyrosine and L-tryptophan in depressed treated patients according to clinical improvement.
Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Erythrocyte Membrane; Female; Fluvoxamine; Humans; Imipramine; Male; Middle Aged; Oximes; Psychological Tests; Tryptophan; Tyrosine | 1988 |
The effect of prolonged treatment with tricyclic antidepressants on the actions of 5-hydroxytryptamine in the hippocampal slice of the rat.
Topics: Animals; Cyproheptadine; Desipramine; Evoked Potentials; Hippocampus; Imipramine; In Vitro Techniques; Ketanserin; Male; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Cerebrospinal fluid levels of amitriptyline, nortriptyline, imipramine and desmethylimipramine. Relationship to plasma levels and treatment outcome.
Topics: Amitriptyline; Bipolar Disorder; Depressive Disorder; Desipramine; Double-Blind Method; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Male; Nortriptyline; Psychiatric Status Rating Scales | 1985 |
QRS interval in tricyclic antidepressant overdose.
Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Desipramine; Electrocardiography; Heart; Humans; Imipramine; Male; Psychotic Disorders | 1988 |
Suicide upon recovery from depression. A clinical note.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans; Imipramine; Recurrence; Suicide; Suicide, Attempted | 1988 |
Personality and depression.
Topics: Adult; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Manuals as Topic; Personality Disorders; Personality Inventory; Psychometrics | 1988 |
Receptors for tricyclic antidepressants in different species.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Carps; Chickens; Cyprinidae; Desipramine; Imipramine; Receptors, Drug; Reptiles; Synaptic Membranes | 1988 |
Measurement of the fractional ratio of demethylation of imipramine in rat by using a co-administration technique.
Topics: Animals; Dealkylation; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains | 1988 |
[A case of dynamic ileus caused by tricyclic antidepressive agents].
Topics: Antidepressive Agents, Tricyclic; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Ileal Diseases; Imipramine; Intestinal Obstruction; Lorazepam; Middle Aged | 1988 |
[3H]imipramine binding of protein nature in human platelets: inhibition by 5-hydroxytryptamine and 5-hydroxytryptamine uptake inhibitors.
Topics: Binding Sites; Binding, Competitive; Blood Platelets; Cell Membrane; Desipramine; Humans; Imipramine; Peptide Hydrolases; Serotonin; Serotonin Antagonists | 1988 |
5-Hydroxytryptamine-sensitive [3H]imipramine binding of protein nature in the human brain. I. Characteristics.
Topics: Adult; Aged; Binding, Competitive; Brain; Desipramine; Endopeptidases; Female; Humans; Imipramine; Male; Middle Aged; Nerve Tissue Proteins; Serotonin; Sodium; Tissue Distribution; Tritium | 1987 |
Patterns of plasma imipramine-desipramine concentrations in patients receiving concomitant fluphenazine decanoate.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Fluphenazine; Humans; Hydroxylation; Imipramine; Male; Middle Aged; Psychotic Disorders; Schizophrenia | 1988 |
The jitteriness syndrome in panic disorder patients treated with antidepressants.
Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Doxepin; Fear; Female; Humans; Imipramine; Male; Panic; Patient Dropouts; Retrospective Studies; Sex Factors; Sleep Initiation and Maintenance Disorders | 1988 |
Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients.
Topics: Adult; Aged; Depressive Disorder; Desipramine; Female; Glucuronates; Humans; Imipramine; Male; Middle Aged; Smoking | 1988 |
First-pass metabolism of imipramine and desipramine: impact of the sparteine oxidation phenotype.
Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Injections, Intravenous; Male; Metabolic Clearance Rate; Phenotype; Sparteine | 1988 |
Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alcoholism; Blood Proteins; Desipramine; Humans; Imipramine; Infusions, Intravenous; Male; Metabolic Clearance Rate; Protein Binding | 1988 |
Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
Topics: Amitriptyline; Clomipramine; Desipramine; Hydrogen-Ion Concentration; Imipramine; Maprotiline; Methadone; Orosomucoid; Psychotropic Drugs; Thioridazine; Trimipramine | 1988 |
Simultaneous determination of imipramine, desipramine and their deuterium-labelled analogues in biological fluids by capillary gas chromatography-mass spectrometry.
Topics: Animals; Chromatography, Gas; Desipramine; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Indicators and Reagents; Male; Rats; Rats, Inbred Strains | 1988 |
Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Cerebral Cortex; Desipramine; Dihydroalprenolol; Imipramine; Kinetics; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Stress, Psychological | 1988 |
High-performance liquid chromatographic determination of imipramine and its metabolites in rat brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains | 1987 |
The neuroendocrine effects of oral imipramine.
Topics: Administration, Oral; Adolescent; Adult; Desipramine; Growth Hormone; Humans; Hydrocortisone; Imipramine; Male; Prolactin | 1987 |
Effect of blood collection tubes on antidepressant concentrations.
Topics: Antidepressive Agents; Blood Specimen Collection; Chromatography, Gas; Desipramine; Humans; Imipramine | 1987 |
Thyroid function and reversal by antidepressant drugs of depressive-like behavior (escape deficits) in rats.
Topics: Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Escape Reaction; Hypothyroidism; Imipramine; Male; Nialamide; Propylthiouracil; Rats; Rats, Inbred Strains; Thyroid Gland; Triiodothyronine | 1987 |
Imipramine administered during an infantile period modifies sex difference in L-5-hydroxytryptophan-induced head shakes in rats.
Topics: 5-Hydroxytryptophan; Age Factors; Animals; Behavior, Animal; Carbidopa; Desipramine; Drug Interactions; Female; Imipramine; Male; Rats; Rats, Inbred Strains; Sex Factors | 1987 |
Antipanic drug effects during lactate infusion in lactate-refractory panic patients.
Topics: Adult; Agoraphobia; Alprazolam; Clonidine; Desipramine; Fear; Female; Fluoxetine; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic; Phobic Disorders; Psychological Tests; Psychotropic Drugs | 1987 |
Quantitative homogeneous enzyme immunoassays for amitriptyline, nortriptyline, imipramine, and desipramine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Cross Reactions; Desipramine; Humans; Imipramine; Immunoenzyme Techniques; Methods; Nortriptyline | 1986 |
Acute effects of nomifensine on in vivo uptake and metabolism of dopamine, noradrenaline and serotonin in the rat brain.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Dopamine; Imipramine; Injections, Intraventricular; Male; Nomifensine; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Analysis of 2-hydroxyimipramine in an imipramine-related fatality.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Desipramine; Female; Humans; Imipramine | 1987 |
Desipramine and imipramine overdose in a psychotic adolescent.
Topics: Adolescent; Desipramine; Humans; Imipramine; Male; Psychotic Disorders; Suicide, Attempted | 1987 |
Effects of albumin and alpha 1-acid glycoprotein on the transport of imipramine and desipramine through the blood-brain barrier in rats.
Topics: Animals; Blood-Brain Barrier; Desipramine; Imipramine; Male; Orosomucoid; Protein Binding; Rats; Serum Albumin | 1987 |
Urinary desipramine hydroxylation index and steady-state plasma concentrations of imipramine and desipramine.
Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged | 1987 |
Imipramine blood levels and clinical outcome.
Topics: Adult; Aged; Aging; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales | 1987 |
Triiodothyronine potentiation of antidepressant-induced reversal of learned helplessness in rats.
Topics: Animals; Avoidance Learning; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Escape Reaction; Helplessness, Learned; Imipramine; Male; Nomifensine; Rats; Rats, Inbred Strains; Triiodothyronine | 1987 |
Plasma-serum differences in the assessment of tricyclic antidepressant blood levels.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Humans; Imipramine; Nortriptyline; Plasma | 1987 |
Subdivision of mouse brain [3H]imipramine binding based on ion dependence and serotonin sensitivity.
Topics: Animals; Binding Sites; Brain; Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Imipramine; Kinetics; Mice; Potassium Chloride; Serotonin; Sodium Chloride; Synaptosomes; Tissue Distribution | 1986 |
Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics.
Topics: Adult; Aged; Biotransformation; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged; Phenotype; Time Factors | 1986 |
Differential effects of cimetidine and ranitidine on imipramine demethylation and desmethylimipramine hydroxylation by human liver microsomes.
Topics: Cimetidine; Dealkylation; Desipramine; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Microsomes, Liver; Ranitidine | 1986 |
Imipramine in adolescent major depression: plasma level and clinical response.
Topics: Adolescent; Age Factors; Anxiety, Separation; Child; Depressive Disorder; Desipramine; Electrocardiography; Female; Gonadal Steroid Hormones; Humans; Imipramine; Male | 1986 |
Targeting imipramine dose in children with depression.
Topics: Absorption; Administration, Oral; Child; Depression; Desipramine; Female; Half-Life; Humans; Imipramine; Kinetics; Male | 1986 |
Successful use of clonazepam in patients with treatment-resistant panic disorder.
Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; Desipramine; Fear; Female; Humans; Imipramine; Male; Middle Aged; Panic; Phenelzine; Propranolol; Psychiatric Status Rating Scales | 1986 |
The lesion of serotonergic neurons does not prevent antidepressant-induced reversal of escape failures produced by inescapable shocks in rats.
Topics: Animals; Antidepressive Agents; Clomipramine; Desipramine; Helplessness, Learned; Imipramine; Male; Nialamide; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1986 |
Profound behavioral toxicity due to tricyclic antidepressants.
Topics: Acute Disease; Adult; Age Factors; Depression; Desipramine; Female; Hospitalization; Humans; Imipramine; Psychoses, Substance-Induced | 1986 |
Cardiovascular effects of polycyclic antidepressants.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression; Desipramine; Doxepin; Female; Heart; Humans; Imipramine; Male; Middle Aged | 1986 |
Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype.
Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Methylation; Oxidation-Reduction; Phenotype; Sparteine | 1986 |
Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.
Topics: Animals; Antidepressive Agents, Tricyclic; Biological Assay; Brain; Cyclohexanols; Desipramine; Dopamine; Guinea Pigs; Imipramine; Monoamine Oxidase Inhibitors; Muscle Contraction; Norepinephrine; Rats; Serotonin; Synaptosomes; Venlafaxine Hydrochloride | 1986 |
Imipramine and tinnitus.
Topics: Adult; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Retrospective Studies; Tinnitus | 1987 |
Imipramine poisoning in a child: lack of efficacy of resin hemoperfusion.
Topics: Child, Preschool; Desipramine; Half-Life; Hemoperfusion; Humans; Imipramine; Male; Physostigmine; Resins, Plant | 1985 |
Tryptamine, a substrate for the serotonin transporter in human platelets, modifies the dissociation kinetics of [3H]imipramine binding: possible allosteric interaction.
Topics: Allosteric Regulation; Antidepressive Agents, Tricyclic; Blood Platelets; Carrier Proteins; Desipramine; Fluoxetine; Humans; Imipramine; Serotonin; Serotonin Antagonists; Tryptamines | 1985 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid Cells; Imipramine; Iprindole; Kinetics; Mianserin; Neuroblastoma; Opipramol; Rats; Serotonin | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
Involvement of amygdaloid catecholaminergic mechanism in suppressive effects of desipramine and imipramine on duration of immobility in rats forced to swim.
Topics: 5,7-Dihydroxytryptamine; Amygdala; Animals; Biogenic Amines; Brain Chemistry; Catecholamines; Desipramine; Hydroxydopamines; Imipramine; Male; Motor Activity; Oxidopamine; Rats; Rats, Inbred Strains; Serotonin; Swimming | 1985 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hippocampus; Imipramine; Maprotiline; Propiophenones; Rats; Trazodone | 1985 |
Desipramine treatment in normal subjects. Effects on neuroendocrine responses to tryptophan and on platelet serotonin (5-HT)-related receptors.
Topics: Adult; Binding Sites; Blood Platelets; Desipramine; Growth Hormone; Humans; Imipramine; Lysergic Acid Diethylamide; Male; Prolactin; Receptors, Serotonin; Serotonin; Tritium; Tryptophan | 1986 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Relationship, Drug; Fibroblasts; Glioma; Humans; Imipramine; Kinetics; Lysosomes; Niemann-Pick Diseases; Phenothiazines; Phosphatidylcholines; Rats; Sphingomyelin Phosphodiesterase; Sphingomyelins | 1986 |
Tricyclic antidepressants in vivo methylation: response to Lydiard and co-workers.
Topics: Amoxapine; Animals; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Kinetics; Loxapine; Methylation; Rabbits | 1986 |
Pharmacokinetics of imipramine are affected by age and sex in rats.
Topics: Aging; Animals; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Male; Preoptic Area; Rats; Sex Factors | 1986 |
Imipramine and desipramine disposition in the elderly.
Topics: Administration, Oral; Adult; Age Factors; Aged; Desipramine; Female; Humans; Imipramine; Injections, Intravenous; Intestinal Absorption; Kinetics; Male; Middle Aged; Sex Factors | 1985 |
Tricyclic antidepressant and metabolite levels in chronic renal failure.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chromatography, Liquid; Depression; Desipramine; Female; Half-Life; Humans; Imipramine; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Nortriptyline; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1985 |
Tolerance to therapeutic effects of antidepressants.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Imipramine; Middle Aged; Recurrence | 1985 |
Uptake and/or binding of tricyclic antidepressants in human red cells.
Topics: Buffers; Cations, Monovalent; Desipramine; Erythrocyte Membrane; Erythrocytes; Haloperidol; Humans; Hydrogen-Ion Concentration; Imipramine; In Vitro Techniques; Kinetics; Orosomucoid; Osmolar Concentration; Plasma; Protein Binding; Serum Albumin; Trifluoperazine | 1985 |
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhydramine; Disease Models, Animal; Electroshock; Ethanol; Humans; Imipramine; Male; Maprotiline; Mianserin; Mice; Motor Activity; Nialamide; Pargyline; Tranylcypromine | 1985 |
Biochemical and diagnostic classification and serum drug levels: relation to antidepressive effect of imipramine.
Topics: Adjustment Disorders; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Retrospective Studies; Tryptophan; Tyrosine | 1985 |
Unchanged platelet 3H-imipramine binding in normal subjects after imipramine administration.
Topics: Adult; Binding Sites; Blood Platelets; Desipramine; Female; Humans; Imipramine; Male | 1985 |
Frequency-dependent block of field potentials in the rat hippocampal slice caused by tricyclic antidepressants.
Topics: Action Potentials; Animals; Antidepressive Agents, Tricyclic; Desipramine; Evoked Potentials; Hippocampus; Imipramine; In Vitro Techniques; Male; Microelectrodes; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Dopamine and isoproterenol in imipramine intoxication in the dog.
Topics: Animals; Desipramine; Dogs; Dopamine; Female; Hemodynamics; Imipramine; Isoproterenol; Male | 1985 |
Pharmacokinetic interaction of disulfiram and antidepressants.
Topics: Adult; Alcoholism; Desipramine; Disulfiram; Drug Interactions; Half-Life; Humans; Hydroxylation; Imipramine; Kinetics; Male; Middle Aged | 1985 |
A sensitive colorimetric method for the determination of imipramine hydrochloride and desipramine hydrochloride.
Topics: Colorimetry; Desipramine; Humans; Imipramine; Spectrophotometry, Ultraviolet; Tablets | 1985 |
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1972 |
Metabolism of amitriptyline, nortriptyline, imipramine and desipramine to yield hydroxylamines.
Topics: Amitriptyline; Animals; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Guinea Pigs; Hydroxylamines; Imipramine; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Mitochondria, Liver; Nortriptyline; Rabbits | 1973 |
The cardiac effects of cocaine and certain antihistamines and antidepressants.
Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpheniramine; Cocaine; Desipramine; Guinea Pigs; Heart; Histamine H1 Antagonists; Imipramine; Nerve Endings; Norepinephrine; Tripelennamine; Triprolidine; Tyramine | 1973 |
Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms.
Topics: Chromatography, Thin Layer; Densitometry; Desipramine; Humans; Imipramine; Methods; Nitrogen Oxides | 1973 |
Imipramine and its metabolites in human brain.
Topics: Adult; Amygdala; Brain Chemistry; Cerebral Cortex; Chromatography, Thin Layer; Corpus Striatum; Desipramine; Frontal Lobe; Humans; Imipramine; Male; Medulla Oblongata; Mesencephalon; Myocardium; Pons; Suicide; Thalamus | 1973 |
A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors.
Topics: Amitriptyline; Animals; Blood Platelets; Carbon Radioisotopes; Chlorpromazine; Desipramine; Dibenzazepines; Doxepin; Imipramine; In Vitro Techniques; Kinetics; Models, Biological; Nortriptyline; Promazine; Rabbits; Serotonin; Synaptosomes; Temperature; Trifluoperazine; Triflupromazine | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Effects of noradrenaline pump blockers on its uptake by synaptosomes from several brain regions; additional evidence for dopamine terminals in the frontal cortex.
Topics: Amitriptyline; Animals; Benztropine; Biological Transport, Active; Carbon Radioisotopes; Cerebral Cortex; Desipramine; Dibenzazepines; Dopamine; Frontal Lobe; Imipramine; Mice; Norepinephrine; Synaptosomes; Tritium | 1974 |
On the spectral intermediate at 440 nm formed during mixed function substrate oxidation.
Topics: Acetanilides; Aniline Compounds; Animals; Barbiturates; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pentobarbital; Proadifen; Protein Binding; Rats; Spectrophotometry, Ultraviolet | 1974 |
Metabolic interconversions and binding of imipramine, imipramine-N-oxide, and desmethylimipramine in rat liver slices.
Topics: Animals; Cytosol; Dealkylation; Desipramine; Female; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Sex Factors; Temperature; Time Factors | 1971 |
The blockade of bulbospinal inhibition by imipramine, desipramine and pargyline.
Topics: Animals; Cats; Caudate Nucleus; Decerebrate State; Desipramine; Electric Stimulation; Electrodes, Implanted; Female; Fenclonine; Imipramine; Laminectomy; Male; Medulla Oblongata; Methyltyrosines; Methysergide; Neural Inhibition; Pargyline; Reflex, Monosynaptic; Spinal Cord; Spinal Nerve Roots; Stereotaxic Techniques; Time Factors; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1974 |
Toxicology of some autopsy cases involving tricyclic antidepressant drugs.
Topics: Adult; Amitriptyline; Antidepressive Agents; Autopsy; Brain Chemistry; Desipramine; Dibenzazepines; Ethanol; Female; Humans; Imipramine; Kidney; Liver; Lung; Male; Middle Aged; Nortriptyline; Protein Binding; Spleen; Stomach | 1974 |
The effect of imipramine, desmethylimipramine and chlorpromazine on the sleep-wakefulness cycle of the cat.
Topics: Animals; Cats; Cerebral Cortex; Chlorpromazine; Circadian Rhythm; Desipramine; Electroencephalography; Electromyography; Eye Movements; Imipramine; Sleep | 1965 |
New metabolites of imipramine.
Topics: Chromatography, Thin Layer; Desipramine; Fluorescence; Humans; Imipramine; Staining and Labeling | 1966 |
A correlation of EEG, reticular multiple unit activity and gross behavior following various antidepressant agents in the cat. IV.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Cats; Chlorpromazine; Desipramine; Electroencephalography; Electromyography; Evoked Potentials; Female; Imipramine; Male; Mesencephalon; Methamphetamine; Pargyline; Perphenazine; Reticular Formation; Seizures; Sleep; Wakefulness | 1969 |
Effects of antidepressant drugs on wakefulness and sleep in the cat.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Chlorpromazine; Circadian Rhythm; Desipramine; Electromyography; Evoked Potentials; Female; Imipramine; Male; Mesencephalon; Methamphetamine; Pargyline; Perphenazine; Reticular Formation; Sleep; Sleep Stages; Time Factors; Wakefulness | 1969 |
[The effect of drugs on the amine storage function of blood platelets].
Topics: Anesthetics, Local; Animals; Biological Transport; Blood Platelets; Catecholamines; Cell Membrane Permeability; Chlorpromazine; Cocaine; Desipramine; Histamine H1 Antagonists; Imipramine; Phenothiazines; Rabbits; Reserpine; Serotonin; Sympathomimetics; Tryptamines | 1969 |
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Dogs; Haplorhini; Hemodynamics; Humans; Imipramine; Mice; Motor Neurons; Muscle Contraction; Rabbits; Rats; Reflex; Respiration; Seizures | 1973 |
On non-specific inhibition of rat liver microsomal UDP glucuronyltransferase by some drugs.
Topics: Alkaloids; Animals; Bilirubin; Desipramine; Enzyme Activation; Glucuronates; Glucuronosyltransferase; Hexosyltransferases; Hydrazines; Imipramine; In Vitro Techniques; Indoles; Iproniazid; Male; Membranes; Microsomes, Liver; Monoamine Oxidase Inhibitors; Nitrophenols; Proteins; Pyridines; Rats; Surface-Active Agents | 1974 |
Adhesion of human blood platelets to glass and polymer surfaces. I. Studies with platelets in plasma.
Topics: Adult; Age Factors; Amitriptyline; Aspirin; Blood Coagulation Disorders; Chloromercuribenzoates; Chlorpromazine; Citrates; Desipramine; Edetic Acid; Glass; Glucosamine; Heparin; Humans; Imipramine; Middle Aged; Platelet Adhesiveness; Polyethylenes; Polymers; Polytetrafluoroethylene; Polyvinyl Chloride; Promethazine; Sulfinpyrazone | 1974 |
[The effect of tricyclic antidepressants on rabbit 5-hydroxytryptophan hyperthermia].
Topics: Animals; Antidepressive Agents; Desipramine; Fever; Imipramine; Nortriptyline; Rabbits; Serotonin; Tryptophan | 1966 |
Anti-inflammatory activity of imipramine and congeners.
Topics: Adenosine Triphosphatases; Alanine Transaminase; Amitriptyline; Animals; Arthritis; Aspartate Aminotransferases; Brain; Bronchial Spasm; Desipramine; Formaldehyde; Histamine; Hydrocortisone; Imipramine; Liver; Lysergic Acid Diethylamide; Phenylbutazone; Rats; Serotonin | 1966 |
Recent studies on the mode of action of antidepressive drugs.
Topics: Animals; Antidepressive Agents; Catecholamines; Central Nervous System; Desipramine; Dihydroxyphenylalanine; Imipramine; Metaraminol; Mice; Neurons; Norepinephrine; Rats; Sympathetic Nervous System; Tritium | 1967 |
Lethal hepatic necrosis after therapy with imipramine and desipramine.
Topics: Aged; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Desipramine; Drug Hypersensitivity; Eosinophilia; Female; Hepatitis; Humans; Imipramine; Necrosis | 1968 |
[Protein binding of some psychoactive drugs with a tricyclic ring system, as a function of their chemical constitution].
Topics: Acepromazine; Alcohols; Amitriptyline; Chemical Phenomena; Chemistry, Physical; Chlorpromazine; Chromatography, Gel; Desipramine; Dialysis; Dibenzazepines; Dibenzocycloheptenes; Imipramine; Phenothiazines; Promazine; Protein Binding; Serum Albumin, Bovine; Thiazines; Triflupromazine | 1970 |
Drugs affecting sodium transport in human erythrocyte ghosts.
Topics: Acetates; Adenosine Triphosphatases; Anesthetics, Local; Biological Transport, Active; Cell Membrane; Chlorpromazine; Desipramine; Dipyridamole; Erythrocytes; Ethacrynic Acid; Furosemide; Humans; Imipramine; Iodine; Lactates; Oligomycins; Ouabain; Potassium; Pyruvates; Sodium | 1970 |
[Action of various tricyclic antidepressive agents on the estrous cycle of the female rat].
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dibenzazepines; Estrus; Female; Imipramine; Keratins; Opipramol; Pregnancy; Rats; Vaginal Diseases | 1970 |
Hepatic and extrahepatic metabolism of the psychotropic drugs, chlorpromazine, imipramine, and imipramine-N-oxide.
Topics: Adipose Tissue; Animals; Bile; Brain; Cecum; Chlorpromazine; Cyclic N-Oxides; Desipramine; Hepatectomy; Imipramine; Intestine, Small; Kidney; Liver; Lung; Male; Muscles; Myocardium; Rats; Rats, Inbred Strains; Skin; Spleen | 1971 |
Influences of intraventricularly administered 5-hydroxytryptamine on normal and amine-depleted rabbit: subcellular distribution of 5-hydroxytryptamine in the brain stem, and animal behaviour.
Topics: Animals; Behavior, Animal; Brain Stem; Cerebral Ventricles; Cytoplasm; Desipramine; Female; Fenclonine; Heart Ventricles; Hydroxyindoleacetic Acid; Imipramine; Injections; Male; Microscopy, Electron; Microsomes; Mitochondria; Rabbits; Reserpine; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Stereotaxic Techniques; Synaptic Vesicles | 1972 |
Effects of some analgesics and antidepressants on the (Na + + K + )-adenosine triphosphatase from cortices of brain and kidney.
Topics: Adenosine Triphosphatases; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cattle; Cerebral Cortex; Chlorpromazine; Cyclazocine; Desipramine; Dose-Response Relationship, Drug; Hydralazine; Imipramine; In Vitro Techniques; Kidney; Kidney Cortex; Pentazocine; Phenazocine; Phenelzine; Potassium; Sodium; Tranylcypromine | 1972 |
Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution.
Topics: Adenosine Triphosphatases; Animals; Antidepressive Agents; Brain; Carbon Isotopes; Cholinesterase Inhibitors; Desipramine; Dibenzazepines; Guinea Pigs; Imipramine; In Vitro Techniques; Microscopy, Electron; Nerve Endings; Opipramol; Potassium; Proteins; Sodium; Subcellular Fractions; Synaptic Vesicles; Synaptosomes; Ultrafiltration | 1973 |
Influence of therapeutic and toxic doses of neuroleptics and antidepressants on energy metabolism of the isolated perfused rat brain.
Topics: Acetone; Ammonia; Animals; Antidepressive Agents; Brain; Creatine; Desipramine; Dose-Response Relationship, Drug; Electroencephalography; Energy Metabolism; Fructosephosphates; Glucose; Glucosephosphates; Glycolysis; Imipramine; Ketoglutaric Acids; Lactates; Male; Organophosphorus Compounds; Perfusion; Phosphocreatine; Promazine; Pyruvates; Rats; Ribonucleotides; Tranquilizing Agents; Trioses | 1973 |
Effect of tricyclic antidepessants on attack elicited by hypothalamic stimulation: relation to brain biogenic amines.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Amines; Brain; Cats; Desipramine; Dibenzazepines; Electric Stimulation; Electrodes, Implanted; Fenclonine; Hydroxydopamines; Hypothalamus; Imipramine; Neurons; Norepinephrine; Serotonin; Time Factors | 1973 |
Proceedings: Treatment of experimental imipramine intoxication by interrupting enteral cycles with activated charcoal.
Topics: Animals; Charcoal; Desipramine; Duodenum; Gastric Mucosa; Imipramine; Kinetics; Liver; Lung; Myocardium; Rats | 1974 |
Uptake, subcellular distribution, and transfer processes of imipramine and its metabolites formed in rat liver perfusion systems.
Topics: Animals; Bile; Carbon Radioisotopes; Cyclic N-Oxides; Cytosol; Desipramine; Endoplasmic Reticulum; Glucuronates; Hydroxylation; Imipramine; Kinetics; Liver; Microsomes, Liver; Perfusion; Rats | 1974 |
Effects of pharmacological agents on the physiological responses of hair discs.
Topics: Acetylcholine; Action Potentials; Alkaloids; Amitriptyline; Animals; Anticonvulsants; Calcium; Catecholamines; Desipramine; Electric Stimulation; Hair; Imipramine; Lobeline; Magnesium; Monoamine Oxidase Inhibitors; Nicotine; Parasympathomimetics; Plants, Medicinal; Plants, Toxic; Potassium; Rats; Reserpine; Sensory Receptor Cells; Serotonin; Skin Physiological Phenomena; Synaptic Transmission; Touch; Veratrum | 1967 |
Systematic identification of psychotropic drugs by thin layer chromatography. II.
Topics: Amitriptyline; Chlorpromazine; Chlorprothixene; Chromatography, Thin Layer; Desipramine; Female; Humans; Imipramine; Male; Meprobamate; Nortriptyline; Phenothiazines; Schizophrenia; Silicon Dioxide; Thioridazine; Tranquilizing Agents | 1968 |
[Effect of imipramine and desipramine on noradrenaline-liberation in sympathetic neurons under calcium-efficiency conditions].
Topics: Animals; Calcium; Desipramine; Ear; Female; Imipramine; In Vitro Techniques; Male; Neurons; Norepinephrine; Rabbits; Sensory Receptor Cells; Sympathetic Nervous System; Synapses; Synaptic Transmission | 1967 |
Correlation between the radioprotective effect of some substances with neurotropic action and inhibition of the respiratory enzymes.
Topics: Chlorpromazine; Desipramine; Dibenzocycloheptenes; Electron Transport Complex IV; Imipramine; Mitochondria, Liver; Radiation-Protective Agents | 1970 |
Effects of antidepressant drugs of the imipramine type on central 5-hydroxytryptamine neurotransmission.
Topics: Amines; Animals; Antidepressive Agents; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Drug Synergism; Fluorescence; Hindlimb; Histocytochemistry; Imipramine; Male; Neurons; Nialamide; Rats; Reflex; Reserpine; Serotonin; Synaptic Transmission; Tryptophan | 1970 |
Differential effects of three tricyclic antidepressants on sleep and REM sleep in the rat.
Topics: Animals; Desipramine; Dibenzazepines; Electroencephalography; Electromyography; Female; Imipramine; Injections, Intraperitoneal; Neck; Rats; Reserpine; Sleep; Sleep, REM | 1970 |
Extraction of amines as complexes with inorganic anions. 6. Extraction of imipramine and desipramine ion pairs with alkyl chloride solvents.
Topics: Alkanes; Bromides; Chlorides; Chloroform; Desipramine; Imipramine; Perchlorates; Sulfonic Acids | 1970 |
Interactions of tricyclic antidepressants and 5-hydroxyindolealkylamine precursors on spinal monosynaptic reflex transmission.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Amitriptyline; Animals; Antidepressive Agents; Cats; Desipramine; Drug Interactions; Drug Synergism; Imipramine; Reflex, Monosynaptic; Serotonin; Spinal Nerves; Synaptic Transmission; Time Factors | 1971 |
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices.
Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine | 1971 |
[Effect of psychotropic drugs on the K + -dependent phosphatase activity in guinea pig brain microsomes].
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Guinea Pigs; Histamine; Hydroxyzine; Imipramine; Meprobamate; Microsomes; Morphine; Nialamide; Phenelzine; Phenobarbital; Phenoxybenzamine; Phosphoric Monoester Hydrolases; Pilocarpine; Potassium; Procaine; Reserpine; Tranquilizing Agents | 1972 |
Effects of desipramine and imipramine on the nerve, muscle and synaptic transmission of rat diaphragms.
Topics: Acetylcholine; Action Potentials; Animals; Axons; Chlorpromazine; Desipramine; Diaphragm; Electric Stimulation; Imipramine; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Neuromuscular Junction; Neurons; Phrenic Nerve; Procaine; Rats; Stimulation, Chemical; Synaptic Transmission | 1972 |
On the treatment of rapid eye movement narcolepsy.
Topics: Adult; Amphetamine; Antidepressive Agents; Cataplexy; Depression; Desipramine; Electroencephalography; Female; Hallucinations; Humans; Hypertension; Imipramine; Male; Methylphenidate; Middle Aged; Narcolepsy; Sleep, REM | 1974 |
Effect of psychotropic drugs on phosphodiesterase and cyclic AMP level in rat brain in vivo.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlorpromazine; Chlorprothixene; Cyclic AMP; Desipramine; Haloperidol; Imipramine; Male; Phosphoric Diester Hydrolases; Rats; Theophylline; Tranquilizing Agents; Triflupromazine; Tritium | 1973 |
Proceedings: Thiamine metabolism in the central nervous system. 2. Effects of psychotropic drugs on rat brain thiamine di- and tri-phosphatase.
Topics: Animals; Brain; Chlorpromazine; Desipramine; Imipramine; Phosphoric Monoester Hydrolases; Rats; Thiamine | 1974 |
Effect of drugs on the activity of thrombocytes 3,5-cyclic AMP phosphodiesterase.
Topics: 1-Propanol; Adenosine Diphosphate; Adenosine Monophosphate; Aminophylline; Blood Platelets; Caffeine; Chlorpromazine; Cyclic AMP; Desipramine; Dibenzothiepins; Epinephrine; Imipramine; Nortriptyline; Phosphoric Diester Hydrolases; Piperazines; Platelet Adhesiveness | 1974 |
Lipid phase transitions and drug interactions.
Topics: Amitriptyline; Binding Sites; Calorimetry; Desipramine; Electron Spin Resonance Spectroscopy; Imipramine; Kinetics; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Biological; Molecular Conformation; Morphinans; Morphine; Nortriptyline; Palmitic Acids; Phosphatidylcholines; Structure-Activity Relationship; Temperature; Thermodynamics | 1974 |
Studies on 14C-imipramine metabolism in the isolated perfused rat liver.
Topics: Animals; Bile; Bucladesine; Carbon Radioisotopes; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Drug Stability; Ethanol; Female; Half-Life; Hydroxylation; Imipramine; In Vitro Techniques; Liver; Oxides; Perfusion; Rats; Spectrophotometry; Time Factors | 1974 |
Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Cyproheptadine; Desipramine; Diphenhydramine; Hallucinogens; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Mice; Promazine; Psychopharmacology; Reserpine; Serotonin | 1965 |
Anorexigenic drugs and lipid mobilisation.
Topics: Amitriptyline; Animals; Appetite Depressants; Chlorphentermine; Desipramine; Dextroamphetamine; Fatty Acids; Imipramine; Lipid Metabolism; Methylphenidate; Piperidines; Rats | 1965 |
Further effects of imipramine and its desmethyl derivative on the hypothermia induced by reserpine.
Topics: Animals; Brain; Brain Chemistry; Catecholamines; Desipramine; Female; Hypothermia, Induced; Imipramine; Injections; Injections, Intraperitoneal; Rats; Reserpine | 1966 |
In vivo inhibition of 3H-noradrenaline uptake by mouse brain slices in vitro.
Topics: Amitriptyline; Amphetamine; Animals; Brain; Chlordiazepoxide; Chlorpromazine; Cocaine; Desipramine; Imipramine; In Vitro Techniques; Mice; Norepinephrine; Tritium | 1966 |
Potentiation of the anticonvulsant action of acetazolamide.
Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism; Electric Stimulation; Electroshock; Ephedrine; Histamine H1 Antagonists; Imipramine; Isoproterenol; Male; Metaraminol; Mice; Morphine; Phenethylamines; Quaternary Ammonium Compounds; Seizures; Stress, Physiological; Tranylcypromine; Tyramine | 1966 |
Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds.
Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chlorpromazine; Desipramine; Hydrogen-Ion Concentration; Imipramine; Perphenazine; Phenothiazines; Prochlorperazine; Promethazine; Solubility; Thioridazine; Tranquilizing Agents; Trifluoperazine; Water | 1967 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine | 1967 |
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; Chlorpromazine; Cocaine; Depression; Desipramine; Emotions; Humans; Imipramine; Lithium; Monoamine Oxidase Inhibitors; Norepinephrine; Normetanephrine; Rats; Reserpine; Tranquilizing Agents; Tritium | 1967 |
Behavioral facilitation: the interaction of imipramine and desipra- mine with amphetamine, alpha-pipradrol, methylphenidate, and thozalinone.
Topics: Amphetamine; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Desipramine; Drug Synergism; Imipramine; Male; Methylphenidate; Oxazoles; Piperidines; Rats; Stimulation, Chemical | 1968 |
Enhanced toxicity of imipramine and desipramine in aggregated mice.
Topics: Animals; Crowding; Desipramine; Drug Synergism; Imipramine; Male; Mice | 1968 |
The influences of drugs on the uptake of 5-hydroxytryptamine by synaptic vesicles of rabbit brain stem.
Topics: Animals; Brain Stem; Cocaine; Desipramine; Imipramine; Male; Nerve Endings; Rabbits; Reserpine; Serotonin | 1968 |
Buccal absorption and other properties of pharmacokinetic importance of imipramine and its metabolites.
Topics: Absorption; Adolescent; Adult; Blood-Brain Barrier; Cheek; Chemical Phenomena; Chemistry, Physical; Desipramine; Female; Humans; Hydrogen-Ion Concentration; Imipramine; Male; Mouth Mucosa; Solvents | 1969 |
Brain desipramine level in relation to the anti-reserpine acitivity of imipramine.
Topics: Animals; Body Temperature; Cats; Desipramine; Female; Imipramine; Proadifen; Reserpine; Tetrabenazine | 1968 |
Evidence for a cholinergic mechanism in brain involved in the tetrabenazine reversal by thymoleptic drugs.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Imipramine; Male; Motor Activity; Nortriptyline; Parasympathetic Nervous System; Rats; Reserpine; Tetrabenazine | 1969 |
Growth inhibition of Crithidia fasciculata by serotoninergic and adrenergic drugs.
Topics: Aminophylline; Amphetamine; Animals; Cyproheptadine; Desipramine; Eukaryota; Hydrazines; Imipramine; Iproniazid; Isoproterenol; Lysergic Acid Diethylamide; Phenoxybenzamine; Prenylamine; Reserpine; Tetrahymena; Tranylcypromine | 1969 |
[Aggressiveness of the rat following combined treatment with monomaime oxidase inhibitors and other psychotropic drugs, especially thymoleptics].
Topics: Aggression; Alkaloids; Amitriptyline; Amphetamine; Animals; Anthracenes; Body Temperature; Central Nervous System; Desipramine; Dibenzazepines; Dihydroxyphenylalanine; Humans; Hydrazines; Imipramine; Indoles; Iproniazid; Isocarboxazid; Male; Nortriptyline; Opipramol; Pargyline; Phenelzine; Rats; Stimulation, Chemical; Tranylcypromine | 1969 |
[Therapy of hypersomnia].
Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Chlorphentermine; Desipramine; Electroencephalography; Ephedrine; Glycolates; Humans; Hydroxybutyrates; Imipramine; Mice; Narcolepsy; Pemoline; Phentermine; Piperidines; Rabbits; Rats; Sleep Wake Disorders; Strychnine; Sympathomimetics | 1967 |
The inhibition of human platelet 5-hydroxytryptamine uptake by tricyclic antidepressive drugs. The relation between structure and potency.
Topics: Amitriptyline; Blood Platelets; Desipramine; Dibenzazepines; Humans; Imipramine; In Vitro Techniques; Serotonin; Serotonin Antagonists | 1969 |
On the mechanism of 5-hydroxytryptamine release by thymoleptics.
Topics: Amitriptyline; Animals; Body Temperature Regulation; Cerebral Cortex; Desipramine; Dibenzazepines; Female; Glucose; Imipramine; Nialamide; Oxygen Consumption; Rabbits; Serotonin; Stimulation, Chemical | 1969 |
Assessment of anti-reserpine and anti-apomorphine activities of some psychic energizers in pigeons.
Topics: Amitriptyline; Animals; Antidepressive Agents; Apomorphine; Columbidae; Deanol; Desipramine; Female; Hydrazines; Imipramine; Male; Opipramol; Orphenadrine; Reserpine; Vomiting | 1969 |
Structural relationship and potency of agents which selectively block mouse killing (muricide) behavior in rats.
Topics: Aggression; Animals; Antidepressive Agents; Behavior, Animal; Central Nervous System Stimulants; Chlorpheniramine; Desipramine; Dextroamphetamine; Histamine H1 Antagonists; Humans; Imipramine; Methamphetamine; Mice; Pargyline; Rats; Tranylcypromine | 1969 |
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.
Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase | 1969 |
Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Carbon Isotopes; Desipramine; Dopamine; Imipramine; Male; Mice; Norepinephrine; Nortriptyline; Serotonin; Tritium; Tryptophan; Tyrosine | 1970 |
Reduction of gastric acid secretion and ulcer formation by 3,3-dimethyl-1-(3-methylaminopropyl)-1-phenylphthalan (Lu 3-010); an inhibitor of noradrenaline uptake.
Topics: Animals; Benzofurans; Depression, Chemical; Desipramine; Gastric Juice; Heart; Imipramine; Male; Mice; Myocardium; Norepinephrine; Peptides; Rats; Stomach; Stomach Ulcer; Tritium | 1970 |
Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slices.
Topics: Animals; Antidepressive Agents; Biological Transport, Active; Brain; Carbon Isotopes; Depression, Chemical; Desipramine; Dibenzazepines; Female; Imipramine; In Vitro Techniques; Injections, Intraperitoneal; Mice; Neurons; Nialamide; Reserpine; Serotonin; Temperature | 1970 |
Modification by a tricyclic series of compounds of the noradrenaline effect on the cat nictitating membrane.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Desipramine; Dibenzazepines; Drug Synergism; Imipramine; Nictitating Membrane; Norepinephrine; Nortriptyline | 1971 |
The effect of drugs upon the uptake of 5-hydroxytryptamine and metaraminol by human platelets.
Topics: Antidepressive Agents; Biological Transport, Active; Blood Platelets; Depression, Chemical; Desipramine; Humans; Imipramine; In Vitro Techniques; Metaraminol; Phenoxybenzamine; Serotonin | 1971 |
Glycine uptake in rat central nervous system slices and homogenates: evidence for different uptake systems in spinal cord and cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport, Active; Carbon Isotopes; Cerebellum; Cerebral Cortex; Chlorpromazine; Chromatography, Paper; Desipramine; Ethylmaleimide; Glycine; Hydrazines; Imipramine; Medulla Oblongata; Mesencephalon; Neurotransmitter Agents; Pons; Rats; Spinal Cord; Synaptic Vesicles; Tritium | 1971 |
Plasma protein binding of tricyclic antidepressive drugs.
Topics: Antidepressive Agents; Blood Platelets; Blood Proteins; Depression, Chemical; Desipramine; Dibenzazepines; Humans; Imipramine; Protein Binding; Serotonin | 1970 |
The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Brompheniramine; Chlorpheniramine; Desipramine; Dibenzazepines; Dihydroxyphenylalanine; Histamine H1 Antagonists; Imipramine; Male; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; Neurons; Nialamide; Norepinephrine; Rats; Reflex; Reserpine; Serotonin | 1971 |
Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.
Topics: Amitriptyline; Animals; Carbon Isotopes; Carbon Monoxide; Chlorpromazine; Cyclic N-Oxides; Cytochromes; Dealkylation; Desipramine; Horses; Imipramine; Kinetics; Liver; Male; NADP; Organ Specificity; Oxidation-Reduction; Proadifen; Rats; Species Specificity; Subcellular Fractions; Swine; Tetrazolium Salts | 1972 |
Effects of imipramine, desipramine and monoamine oxidase inhibitors on the metabolism and psychomotor stimulant actions of d-amphetamine in mice.
Topics: Animals; Brain; Depression, Chemical; Desipramine; Dextroamphetamine; Drug Synergism; Hydrazines; Imipramine; Iproniazid; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Pargyline; Species Specificity; Stimulation, Chemical; Sulfuric Acids; Time Factors; Tritium | 1971 |
Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man.
Topics: Amphetamine; Animals; Chlorpromazine; Desipramine; Drug Interactions; Histamine; Hydrazines; Hydrocortisone; Imipramine; Iproniazid; Male; Meperidine; Methylation; Microsomes, Liver; Monoamine Oxidase Inhibitors; Nialamide; Opipramol; Phenothiazines; Phenylhydrazines; Prednisolone; Proadifen; Promazine; Rats; Transferases | 1972 |
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine | 1972 |
Effect of dimethyl and monomethyl tricyclic antidepressants on central 5-hydroxytryptamine processes in the frog.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anura; Brain; Desipramine; Dibenzazepines; Imipramine; Male; Muscle Contraction; Nortriptyline; Rana temporaria; Serotonin | 1971 |
[Tricyclic anti-depressant drugs and dopamine sensitive adenylcyclase from rat caudate nuclei].
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amitriptyline; Animals; Antidepressive Agents; Basal Metabolism; Caudate Nucleus; Chlorpromazine; Desipramine; Dopamine; Imipramine; Nortriptyline; Rats; Stimulation, Chemical | 1974 |
Deamination of beta-phenylethylamine by monoamine oxidase--inhibition by imipramine.
Topics: Animals; Brain; Carbon Radioisotopes; Deamination; Desipramine; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Iproniazid; Kinetics; Lung; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Phenethylamines; Phenylacetates; Protein Binding; Rabbits; Serotonin; Tyramine | 1974 |
Effect of prothiadene on the function and metabolism of human thrombocytes.
Topics: Absorption; Adenosine Diphosphate; Blood Platelets; Depression, Chemical; Desipramine; Dibenzothiepins; Dothiepin; Drug Antagonism; Epinephrine; Humans; Imipramine; In Vitro Techniques; Platelet Adhesiveness; Platelet Aggregation; Serotonin | 1974 |
Blockade of heart 3H-norepinephrine up-take by 4-phenyl-1-aminotetralines: implications for the active conformation of imipramine-like drugs.
Topics: Amines; Animals; Body Temperature; Crystallography; Depression, Chemical; Desipramine; Dose-Response Relationship, Drug; Imipramine; Male; Mice; Molecular Conformation; Myocardium; Naphthalenes; Norepinephrine; Rats; Reserpine; Stereoisomerism; Structure-Activity Relationship; Time Factors; Tritium | 1974 |
The effects of hypnotics on imipramine treatment.
Topics: Adult; Amobarbital; Depression; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Imipramine; Male; Middle Aged; Nitrazepam; Psychiatric Status Rating Scales; Sleep; Spectrometry, Fluorescence | 1974 |
Combined thyroid (triiodothyronine)-tricyclic antidepressant treatment in depressive states.
Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents; Anxiety; Bipolar Disorder; Blood Pressure; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Motor Activity; Nortriptyline; Pulse; Time Factors; Triiodothyronine; Verbal Behavior | 1974 |
Quantitative determination of imipramine and desmethylimipramine in human plasma by mass fragmentography.
Topics: Chromatography, Gas; Depression; Desipramine; Humans; Imipramine; Mass Spectrometry | 1974 |
The "on-off" side effect of L-DOPA.
Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Catechol O-Methyltransferase Inhibitors; Chlordiazepoxide; Chorea; Desipramine; Diazepam; Dietary Proteins; Enzyme Inhibitors; Female; Humans; Imipramine; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Physical Exertion; Picolinic Acids; Prochlorperazine; Sex Factors; Stress, Psychological | 1974 |
[Analysis of the monoaminergic mechanisms of the dorsal hippocampus actualizing conditioned avoidance reactions in rats].
Topics: Animals; Avoidance Learning; Chlorpromazine; Conditioning, Classical; Depression, Chemical; Desipramine; Dihydroergotamine; Dopamine; Drug Interactions; Haloperidol; Hippocampus; Imipramine; Male; Motor Activity; Muscle Tonus; Norepinephrine; Perphenazine; Phentolamine; Rats; Reaction Time; Serotonin | 1974 |
Comparison of the effects of tetracyclic and tricyclic antidepressants on the serotonin uptake by human thrombocytes in vitro.
Topics: Antidepressive Agents; Blood Platelets; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Serotonin | 1974 |
True and apparent non-penetration of the blood brain barrier by psychotropic drugs.
Topics: Animals; Biotransformation; Blood-Brain Barrier; Desipramine; Imipramine; Rats | 1974 |
Effects of imipramine and desipramine on responses of single cortical neurones to noradrenaline and 5-hydroxytryptamine.
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Desipramine; Drug Interactions; Female; Glutamates; Imipramine; Male; Neurons; Norepinephrine; Serotonin; Serotonin Antagonists | 1974 |
[Agrypnia anesthesia with imipramine and/or desipramine].
Topics: Adult; Chemical Phenomena; Chemistry; Desipramine; Drug Evaluation; Humans; Imipramine; Male; Middle Aged; Neuroleptanalgesia; Pain | 1974 |
Quantitative analysis of the EEG effects produced by imipramine, desipramine promazine, and monodesmethyl promazine in the isolated perfused rat brain.
Topics: Analysis of Variance; Animals; Brain; Desipramine; Electroencephalography; Imipramine; In Vitro Techniques; Male; Perfusion; Promazine; Rats | 1974 |
Pharmacokinetic interaction between neuroleptics and tricyclic antidepressants in the rat.
Topics: Animals; Brain; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Erythrocytes; Feces; Glucuronates; Heart; Imipramine; Injections, Intraperitoneal; Male; Nortriptyline; Perphenazine; Rats | 1974 |
Serious side effects from routine doses of non-Mao inhibitor antidepressants. How "well" is well tolerated?
Topics: Adult; Amitriptyline; Antidepressive Agents; Desipramine; Drug Tolerance; Female; Humans; Imipramine; Male; Middle Aged | 1973 |
A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Hallucinogens; Humans; Imipramine; In Vitro Techniques; Indoles; Lung; Mass Spectrometry; Methylation; Methyltransferases; N,N-Dimethyltryptamine; Rabbits; S-Adenosylmethionine; Schizophrenia; Serotonin; Solvents; Tetrahydrofolates; Time Factors; Tryptamines | 1974 |
Cardiac effects of antidepressants.
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidepressive Agents; Coronary Circulation; Depression, Chemical; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Dimethylamines; Electrocardiography; Female; Guinea Pigs; Heart; Heart Conduction System; Imipramine; In Vitro Techniques; Male; Oximes; Rats; Vasopressins | 1972 |
Drug-induced changes of 5-hydroxyindoles in central nervous system in the rats.
Topics: 5-Hydroxytryptophan; Animals; Brain; Chlorpromazine; Desipramine; Female; Hydroxyindoleacetic Acid; Imipramine; Indoles; Iproniazid; Male; Rats; Reserpine; Serotonin | 1973 |
In vitro experiments on the metabolism, accumulation and release of 5-HT in the nervous system of the snail Helix pomatia.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Biological Transport, Active; Calcium; Carbon Radioisotopes; Chromatography, Thin Layer; Desipramine; Electric Stimulation; Ganglia; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Isotope Labeling; Magnesium; Nerve Tissue; Ouabain; Phenylalanine; Serotonin; Snails; Sorbitol; Structure-Activity Relationship; Temperature; Time Factors; Tritium; Tryptophan | 1974 |
Incorporation of imipramine into isolated rat peritoneal mast cells in vitro.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Binding Sites; Calcium; Cell Membrane Permeability; Chlorpromazine; Cocaine; Depression, Chemical; Desipramine; Dibenzazepines; Female; Guanethidine; Hydrogen-Ion Concentration; Imipramine; Leukocytes; Male; Mast Cells; Nortriptyline; Rats; Receptors, Drug; Reserpine; Serotonin; Temperature | 1974 |
Functional group contribution in ion-pair extraction of tricyclic amines.
Topics: Amitriptyline; Bromides; Chemical Phenomena; Chemistry; Chlorates; Chlorides; Desipramine; Imipramine; Iodides; Ions; Mathematics; Naphthalenes; Nitrates; Nortriptyline; Spectrophotometry, Ultraviolet; Tosyl Compounds | 1972 |
[Method for the detection of imipraminic antidepressants in urine by gas chromatography and thin layer chromatography].
Topics: Antidepressive Agents; Chromatography, Gas; Chromatography, Thin Layer; Desipramine; Dibenzazepines; Imipramine; Methods | 1972 |
Route of administration and drug metabolism.
Topics: Administration, Oral; Animals; Brain Chemistry; Computers; Desipramine; Imipramine; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Kidney; Kinetics; Liver; Mathematics; Models, Biological; Pharmaceutical Preparations; Rats; Time Factors | 1972 |
Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats.
Topics: Animals; Desipramine; Electric Stimulation; Female; Hydroxyindoleacetic Acid; Imipramine; Mesencephalon; Rats; Serotonin | 1972 |
[Innervation of efferent seminal ducts in man: site of action and effects of psychotropic drugs].
Topics: Affective Symptoms; Amitriptyline; Desipramine; Humans; Imipramine; Infertility, Male; Male; Norepinephrine; Serotonin; Vas Deferens | 1972 |
Uptake of desipramine by the rat vas deferens.
Topics: Animals; Cocaine; Denervation; Desipramine; Dinitrophenols; Dose-Response Relationship, Drug; Drug Synergism; Imipramine; In Vitro Techniques; Iodoacetates; Kinetics; Male; Norepinephrine; Ouabain; Rats; Temperature; Time Factors; Vas Deferens | 1972 |
Proceedings: Effect of tricyclic antidepressants on drug metabolism.
Topics: Adult; Amitriptyline; Animals; Antidepressive Agents; Antipyrine; Desipramine; Dibenzazepines; Female; Half-Life; Hexobarbital; Humans; Imipramine; Liver; Male; Nortriptyline; Rats | 1972 |
Relationship between substances strengthening of the thrombocyte cell membrane on the aggregation of thrombocytes and on the uptake and release of serotonin.
Topics: Adenosine Diphosphate; Amitriptyline; Benzothiepins; Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Colorimetry; Desipramine; Epinephrine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phentolamine; Piperazines; Platelet Adhesiveness; Propranolol; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Tranquilizing Agents | 1972 |
Noradrenaline uptake mechanisms in human atrium.
Topics: Adolescent; Adult; Animals; Binding Sites; Cell Membrane; Chlorpromazine; Desipramine; Dibenzazepines; Drug Interactions; Humans; Hydroxydopamines; Imipramine; Metaraminol; Middle Aged; Myocardium; Nialamide; Norepinephrine; Rats; Receptors, Adrenergic; Receptors, Drug; Reserpine; Sorbitol; Tritium | 1972 |
Binding of cyproheptadine-(N-methyl- 14 C) by human blood platelets: inhibition by phenothiazines and tricyclic antidepressants.
Topics: Amitriptyline; Blood Platelets; Carbon Isotopes; Centrifugation; Chlorpromazine; Cyproheptadine; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phenothiazines; Platelet Adhesiveness; Promethazine | 1973 |
Central antisecretory action of desmethylimipramine in the rat.
Topics: Animals; Central Nervous System; Chlorpromazine; Desipramine; Gastric Juice; Gastric Mucosa; Imipramine; Injections, Intravenous; Male; Morphine; Rats; Stomach | 1973 |
A comparison of 1-p-acetyldeoxyephedrine and 4-methyl- -ethyl-m-tyramine as to lowering of brain serotonin, and their antagonism by antidepressants.
Topics: Acetates; Animals; Antidepressive Agents; Brain Chemistry; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Ephedrine; Female; Fluorometry; Imipramine; In Vitro Techniques; Methamphetamine; Methyltyrosines; Mice; Monoamine Oxidase Inhibitors; Serotonin; Time Factors; Tritium | 1973 |
An explanatory statistical model for plasma levels of imipramine and desmethylimipramine during long-term therapy.
Topics: Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Mental Disorders; Models, Theoretical; Statistics as Topic | 1973 |
Emergency toxicological screening for drugs commonly taken in overdose.
Topics: Acetaminophen; Antidepressive Agents; Barbiturates; Benzazepines; Chloral Hydrate; Chromatography, Thin Layer; Colorimetry; Desipramine; Emergencies; Hallucinogens; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Narcotics; Pharmaceutical Preparations; Phenothiazines; Poisoning; Psychoses, Substance-Induced; Salicylates; Solvents | 1973 |
Formation of N-glucuronide of desmethylimipramine in the dog.
Topics: Animals; Bile; Desipramine; Dogs; Female; Glucuronates; Imipramine | 1973 |
Comparison of the effects of imipramine and desipramine on single cortical neurones.
Topics: Animals; Cats; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Electrophoresis; Imipramine; Neurons; Norepinephrine; Serotonin Antagonists | 1973 |
Studies on the disposition of amitriptyline and other tricyclic antidepressant drugs in man as it relates to the management of the overdosed patient.
Topics: Adult; Amitriptyline; Antidepressive Agents; Charcoal; Chromatography, Gas; Desipramine; Female; Gastric Juice; Humans; Imipramine; Male; Mass Spectrometry; Nortriptyline; Poisoning | 1973 |
Influence of orphenadrine HC1 and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices.
Topics: Animals; Brain; Carbon Radioisotopes; Desipramine; Germ-Free Life; Imipramine; In Vitro Techniques; Kinetics; Male; Norepinephrine; Orphenadrine; Rats; Serotonin | 1973 |
Permeability changes in the blood-brain barrier induced by nortriptyline and chlorpromazine.
Topics: Amitriptyline; Animals; Autoradiography; Blood-Brain Barrier; Brain; Capillaries; Carbon Radioisotopes; Cell Membrane Permeability; Cerebral Cortex; Chlorpromazine; Desipramine; Diphenhydramine; Dopamine; Imipramine; In Vitro Techniques; Inulin; Male; Mannitol; Molecular Weight; Nortriptyline; Rats; Tritium | 1973 |
Effect of thymoleptics on fenfluramine-induced depletion of brain serotonin in rats.
Topics: Animals; Antidepressive Agents; Appetite; Brain; Brain Stem; Depression, Chemical; Desipramine; Dibenzazepines; Diencephalon; Female; Fenfluramine; Imipramine; Propylamines; Rats; Serotonin; Telencephalon; Time Factors; Tranquilizing Agents | 1973 |
The interference of tricyclic antidepressants with the central hypotensive effect of clonidine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Cats; Clonidine; Desipramine; Imipramine; Time Factors | 1973 |
[Evaluation of central antireserpine effect by the use of light blink reflex (author's transl)].
Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Chlorpromazine; Chlorprothixene; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Diethylamines; Dimethylamines; Ethylenediamines; Glycolates; Imipramine; Light; Nortriptyline; Propylamines; Rabbits; Reflex; Reserpine | 1973 |
Stimulation of drug metabolism in man by tricyclic antidepressants.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Amitriptyline; Amobarbital; Analysis of Variance; Antidepressive Agents; Antipyrine; Desipramine; Dibenzazepines; Female; Half-Life; Humans; Hydrocortisone; Hydroxycorticosteroids; Imipramine; Male; Nortriptyline; Stimulation, Chemical; Time Factors | 1973 |
Effects of antidepressant agents on open field behaviour in rats.
Topics: Animals; Behavior, Animal; Desipramine; Humans; Imipramine; Male; Nortriptyline; Pargyline; Rats; Stereotyped Behavior; Time Factors; Tranylcypromine | 1973 |
Biological and pharmacokinetic evidence for generic equivalence of three imipramine preparations: comparison with a new imipramine analogue.
Topics: Animals; Depression; Desipramine; Humans; Imipramine; Iris; Norepinephrine; Solubility; Tablets; Therapeutic Equivalency; Tritium | 1973 |
Treatment of incontinent boys with non-obstructive disease.
Topics: Anti-Infective Agents, Urinary; Behavior Therapy; Child; Desipramine; Encopresis; Enema; Enuresis; Humans; Hypnosis; Imipramine; Intestinal Obstruction; Male; Parent-Child Relations; Reward; Suggestion; Urinary Incontinence; Urinary Tract Infections | 1974 |
The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction.
Topics: Amitriptyline; Amphetamine; Animals; Biogenic Amines; Catecholamines; Chlorine; Chlorpheniramine; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Female; Haloperidol; Imipramine; Methyltyrosines; Motor Activity; Rats; Receptors, Cholinergic; Serotonin Antagonists; Spiro Compounds; Time Factors | 1974 |
Inhibition of lung, liver and brain monoamine oxidase by imipramine and desipramine.
Topics: Animals; Biogenic Amines; Brain; Carbon Radioisotopes; Desipramine; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Liver; Lung; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Rabbits; Serotonin; Serotonin Antagonists | 1974 |
Comparison of tricyclic antidepressants in rabbits: antinociception and potentiation of the noradrenaline pressor responses.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Aorta; Blood Pressure; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Imipramine; In Vitro Techniques; Iprindole; Lithium; Morphine; Norepinephrine; Nortriptyline; Opipramol; Rabbits; Succinimides; Time Factors | 1974 |
Imipramine and chlorpromazine in hepatic microsomal systems.
Topics: Animals; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Microsomes, Liver; Phenobarbital; Proadifen; Proteins; Spectrophotometry, Ultraviolet | 1974 |
Imipramine protein binding and pharmacokinetics in children.
Topics: Age Factors; Blood Proteins; Carbon Radioisotopes; Child Behavior Disorders; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Protein Binding; Psychiatric Status Rating Scales; Time Factors | 1974 |
Effect of maprotiline, a new antidepressant drug, on serotonin uptake.
Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Blood Platelets; Brain Chemistry; Bridged-Ring Compounds; Depression, Chemical; Desipramine; Diencephalon; Female; Fluorometry; Humans; Imipramine; Mesencephalon; Norepinephrine; Phenethylamines; Propylamines; Rats; Serotonin; Synaptosomes; Time Factors; Tritium | 1974 |
Treatment of the depressed outpatient.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Child; Chlordiazepoxide; Depression; Desipramine; Diazepam; Humans; Hydroxyzine; Imipramine; Lithium; Methylphenidate; Outpatient Clinics, Hospital; Suicide; Tranylcypromine | 1974 |
[Effect of thymoleptica in the drawing test].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Female; Humans; Imipramine; Middle Aged; Personality Disorders; Projective Techniques; Psychological Tests | 1967 |
Suppression of hippocampal DFP discharges by chlorpromazine, imipramine and desipramine.
Topics: Animals; Cats; Chlorpromazine; Depression, Chemical; Desipramine; Drug Antagonism; Hippocampus; Imipramine; Isoflurophate; Male; Membrane Potentials; Stereotaxic Techniques | 1971 |
[Binding to human serum proteins of drugs belonging to phenothiazine series, iminodibenzyle, thioxanthene and thiophenylpyridylamine].
Topics: Antidepressive Agents; Blood Proteins; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Chromatography, Gel; Desipramine; Dibenzazepines; Humans; Imipramine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Protein Binding; Spectrophotometry; Thiazines; Trimeprazine | 1971 |
A potential clinical use for methylphenidate with tricyclic antidepressants.
Topics: Adult; Aged; Animals; Chloral Hydrate; Chromatography, Thin Layer; Depression; Desipramine; Dextroamphetamine; Drug Synergism; Electroconvulsive Therapy; Female; Haplorhini; Humans; Imipramine; Liver; Male; Methylphenidate; Mice; Middle Aged; Psychotherapy; Rats | 1971 |
Pharmacological studies of 5-methyl-8-ethyl-sulfonyl-10-(2-dimethylaminoethyl)-5H-dibenzo (B,E) (1,4) diazepine-11 (10)-one (SM-307), an antidepressive substance.
Topics: Amitriptyline; Animals; Antidepressive Agents; Barbiturates; Behavior, Animal; Body Temperature; Cats; Desipramine; Dibenzazepines; Dopamine; Epinephrine; Haplorhini; Ileum; Imipramine; In Vitro Techniques; Male; Mice; Monoamine Oxidase; Muscle, Smooth; Norepinephrine; Rats; Reserpine; Respiration | 1971 |
Blocking H 3 -Norepinephrine uptake and some guanethidine-induced effects with tricyclic psychotherapeutic drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Autonomic Fibers, Postganglionic; Benzofurans; Blood Pressure; Cats; Chlorpromazine; Desipramine; Dibenzoxepins; Electric Stimulation; Guanethidine; Heart; Imipramine; Male; Methylamines; Myocardium; Nictitating Membrane; Norepinephrine; Rats; Rats, Inbred Strains; Thioridazine; Tranquilizing Agents; Tritium | 1972 |
Studies on the accumulation of O-methylated dopamine and noradrenaline in the rat brain following various neuroleptics, thymoleptics and aceperone.
Topics: Acetamides; Animals; Antidepressive Agents; Benzimidazoles; Brain; Brain Chemistry; Butyrophenones; Chlorpromazine; Chlorprothixene; Desipramine; Dopamine; Imipramine; Ketones; Male; Methylation; Norepinephrine; Normetanephrine; Pargyline; Piperidines; Rats; Stimulation, Chemical; Tranquilizing Agents; Tyramine | 1972 |
Fluorimetric determinations by ion pair extraction. 3. Extraction constants of ion pairs between anthracene-2-sulphonate and mono- and divalent amines.
Topics: Amines; Amitriptyline; Anthracenes; Desipramine; Dibenzazepines; Emetine; Hydrocarbons, Halogenated; Imipramine; Ions; Nortriptyline; Prenylamine; Spectrometry, Fluorescence; Sulfonic Acids | 1972 |
Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs.
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Benztropine; Brain; Brain Chemistry; Cocaine; Desipramine; Dopamine; Imipramine; Iproniazid; Male; Motor Activity; Nialamide; Norepinephrine; Normetanephrine; Parasympatholytics; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tropanes; Tyramine | 1972 |
Toxic interactions of d-amphetamine and tricyclic antidepressants in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Drug Antagonism; Drug Interactions; Drug Synergism; Imipramine; Injections, Intraperitoneal; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nortriptyline; Promazine; Time Factors | 1972 |
Hypothalamic endogenous noradrenaline and thermoregulation in the cat and rabbit.
Topics: Animals; Body Temperature Regulation; Cats; Cerebral Ventricles; Desipramine; Hypothalamus; Imipramine; Injections; Mandelic Acids; Methyltyrosines; Norepinephrine; Normetanephrine; Rabbits; Serotonin; Time Factors | 1972 |
[Effect of the tricyclic antidepressants--imizin, desipramine, amitryptyline and azaphen on gastric secretion in rats].
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Gastric Juice; Gastric Mucosa; Imipramine; Male; Oxazines; Piperazines; Pyrimidines; Rats; Stomach | 1972 |
Rophe neurons: effect of tricyclic antidepressant drugs.
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dibenzazepines; Imipramine; Male; Mesencephalon; Nerve Endings; Phenylalanine; Rats; Serotonin | 1972 |
Interaction between digoxin and tricyclic antidepressants in the rat.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Heart; Heart Arrest; Imipramine; Male; Nortriptyline; Rats; Reserpine; Stress, Physiological | 1972 |
[Effect of thymoleptic agents on the motor function of the bladder (animal experiments and clinical studies)].
Topics: Adult; Aged; Animals; Cats; Desipramine; Enuresis; Female; Humans; Imipramine; Male; Manometry; Middle Aged; Muscle Contraction; Urinary Bladder | 1972 |
The use of psychopharmacological drugs in the aged.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Anxiety; Barbiturates; Butyrophenones; Dementia; Desipramine; Dextroamphetamine; Diazepam; Humans; Imipramine; Isocarboxazid; Mental Disorders; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Phenothiazines; Phytotherapy; Piperazines; Plants, Medicinal; Rauwolfia; Thiothixene; Tranquilizing Agents; Tranylcypromine; Xanthenes | 1971 |
[Stereotypy following amphetamine and apomorphine and its influencing by drugs].
Topics: Amitriptyline; Amphetamine; Animals; Apomorphine; Behavior, Animal; Desipramine; Drug Synergism; Female; Imipramine; Mastication; Mice; Rats; Tranquilizing Agents | 1971 |
Detection of some psychotherapeutic drugs and their metabolites in urine.
Topics: Amitriptyline; Amphetamine; Analgesics; Antidepressive Agents; Chlordiazepoxide; Chlorpromazine; Chromatography, Thin Layer; Desipramine; Diazepam; Fluphenazine; Haloperidol; Humans; Imipramine; Indicators and Reagents; Methadone; Perphenazine; Solvents; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1971 |
[Identification of tricyclic antidepressants derived from imipramine by gas chromatography].
Topics: Antidepressive Agents; Chromatography, Gas; Desipramine; Dibenzazepines; Imipramine; Methods | 1971 |
Antidepressant overdosage in children--a new menace.
Topics: Accidents, Home; Adolescent; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child; Child, Preschool; Desipramine; Drug Compounding; Drug Packaging; Humans; Imipramine; Infant; Seizures | 1971 |
GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors.
Topics: Aminobutyrates; Animals; Caproates; Carnitine; Centrifugation, Density Gradient; Cerebellum; Cerebral Cortex; Chlorpromazine; Cysteamine; Desipramine; Dithiothreitol; Ethylmaleimide; Haloperidol; Hippocampus; Imipramine; Ornithine; Pimelic Acids; Propionates; Rats; Spinal Cord; Sulfanilamides; Synaptic Vesicles; Taurine; Tritium; Valerates | 1971 |
Aspects of the gastric acid antisecretory activity of 3,3-dimethyl-1-(3-methylaminopropyl)-1-phenylphthalan: a blocker of norepinephrine uptake.
Topics: Animals; Antacids; Benzofurans; Bridged-Ring Compounds; Depression, Chemical; Desipramine; Drug Antagonism; Female; Gastric Juice; Histamine; Imipramine; Methyltyrosines; Norepinephrine; Peptides; Rats; Reserpine; Stomach Ulcer; Structure-Activity Relationship; Succinates; Tranquilizing Agents | 1971 |
Interaction of imipramine, desmethylimipramine, nortriptyline and 1-naphthol with microsomal preparations.
Topics: Animals; Desipramine; Drug Interactions; Hydroxylation; Imipramine; Microsomes, Liver; Naphthalenes; Naphthols; Nortriptyline; Rats | 1971 |
Noradrenergic mechanism in the central control of body temperature.
Topics: Animals; Body Temperature Regulation; Cats; Desipramine; Female; Hypothalamus; Imipramine; Male; Norepinephrine; Rabbits | 1971 |
Comparison of the effects of drugs on the aggregation of hamster platelets in vivo and in vitro.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aspirin; Blood Volume; Carbon Isotopes; Cheek; Cricetinae; Desipramine; Imipramine; In Vitro Techniques; Iontophoresis; Microcirculation; Platelet Adhesiveness; Sodium Salicylate; Tritium | 1971 |
Brain levels of imipramine and desipramine after combined treatment with these drugs in rats.
Topics: Analysis of Variance; Animals; Brain Chemistry; Desipramine; Female; Imipramine; Rats; Rats, Inbred Strains; Time Factors | 1971 |
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine | 1971 |
[Changes in tonus of the bladder and its sphincter under thymoleptic treatment. Cystomanometric measurements in man].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Carbachol; Desipramine; Dibenzazepines; Enuresis; Humans; Imipramine; Manometry; Middle Aged; Muscle Tonus; Nortriptyline; Pressure; Urinary Bladder; Water-Electrolyte Balance | 1971 |
Blockade of noradrenaline uptake by 34276-Ba, a new antidepressant drug.
Topics: Amines; Animals; Anthracenes; Antidepressive Agents; Brain; Cats; Chick Embryo; Desipramine; Dose-Response Relationship, Drug; Guanethidine; Imipramine; In Vitro Techniques; Male; Metaraminol; Myocardium; Neurons; Norepinephrine; Propylamines; Rats; Salivary Glands; Spleen; Time Factors; Tritium; Vas Deferens | 1971 |
Central effects of 6-hydroxydopamine.
Topics: Amantadine; Amitriptyline; Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Desipramine; Dopamine; Electroencephalography; Female; Humans; Hydroxydopamines; Imipramine; Male; Mice; Motor Activity; Norepinephrine; Rats; Seizures; Species Specificity; Stereotyped Behavior | 1971 |
[Differential therapeutic experiments with antidepressive efficacious psychopharmacotics].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Humans; Imipramine; Psychopharmacology; Thioridazine | 1967 |
Central muscle relaxant activity of imipramine, amitriptyline and desmethylimipramine.
Topics: Amitriptyline; Animals; Cats; Central Nervous System; Desipramine; Female; Imipramine; Male; Muscles | 1966 |
Further evidence of central muscle relaxant activity of imipramine, desmethylimipramine and amitriptyline.
Topics: Amitriptyline; Animals; Behavior, Animal; Blood Pressure; Cats; Desipramine; Female; Imipramine; Male; Mephenesin; Muscle Contraction; Muscles; Rabbits; Reflex | 1966 |
5-hydroxytryptamine uptake by rat brain in vitro.
Topics: 5-Hydroxytryptophan; Adenosine Triphosphate; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cocaine; Desipramine; Dinitrophenols; Dopamine; Glucose; Imipramine; In Vitro Techniques; Iodoacetates; Iproniazid; Male; Norepinephrine; Ouabain; Rats; Reserpine; Serotonin; Serotonin Antagonists; Tryptamines | 1967 |
Muricidal block produced by 5-hydroxytryptophan and various drugs.
Topics: 5-Hydroxytryptophan; Aggression; Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Desipramine; Humans; Imipramine; Injections, Intraperitoneal; Male; Mice; Rats | 1968 |
Effect of psychotherapeutic drugs on hyperemotionality of rats in which the olfactory bulb was removed.
Topics: Amitriptyline; Animals; Benperidol; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Desipramine; Emotions; Imipramine; Limbic System; Male; Meprobamate; Phenobarbital; Rats; Reserpine; Tranquilizing Agents | 1967 |
Central muscle relaxant activity of a dozen CNS active agents and a correlation with their psychotropic activity.
Topics: Amphetamine; Animals; Antidepressive Agents; Blood Pressure; Cats; Central Nervous System; Chlorpromazine; Desipramine; Dibenzothiazepines; Ephedrine; Female; Imipramine; Iproniazid; Male; Mephenesin; Monoamine Oxidase Inhibitors; Muscles; Orphenadrine; Phenelzine; Reflex; Thioridazine; Tranquilizing Agents | 1968 |
Synergism of imipramine and desmethylimipramine with reserpine in the frog. Interaction with 5-hydroxytryptophan and 2-bromolysergid diethylamide (BOL-148).
Topics: 5-Hydroxytryptophan; Animals; Anura; Brain Chemistry; Chlorpromazine; Desipramine; Drug Synergism; Epinephrine; Imipramine; Lysergic Acid Diethylamide; Norepinephrine; Rats; Reserpine | 1968 |
Demonstration of extraneuronal 5-hydroxytryptamine accumulation in brain following membrane-pump blockade by chlorimipramine.
Topics: 5-Hydroxytryptophan; Animals; Brain; Desipramine; Dibenzazepines; Dopamine; Dopamine Antagonists; Drug Synergism; Histocytochemistry; Imipramine; Mice; Microscopy, Fluorescence; Motor Activity; Nialamide; Rats; Reserpine; Serotonin; Time Factors | 1969 |
Plasma protein binding of tricyclic anti-depressants in man.
Topics: Amitriptyline; Antidepressive Agents; Blood Proteins; Carbon Isotopes; Desipramine; Humans; Imipramine; Nortriptyline; Phenytoin; Protein Binding; Temperature; Tritium | 1969 |
Pharmacological effects of imipramine and desmethylimipramine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Blepharoptosis; Brain Chemistry; Chlorpromazine; Desipramine; Diarrhea; Female; Hypnotics and Sedatives; Hypothermia, Induced; Imipramine; Male; Motor Activity; Norepinephrine; Quinolizines; Rats; Reserpine | 1969 |
Metabolism of 14C-imipramine. II. Urinary metabolites in man.
Topics: Autoradiography; Carbon Isotopes; Chromatography, Thin Layer; Desipramine; Feces; Female; Fluorescence; Glucuronates; Humans; Hydrogen-Ion Concentration; Imipramine; Male; Methods; Sex Factors | 1969 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Female; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Psychopharmacology | 1969 |
Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antimetabolites; Brain; Cocaine; Desipramine; Imipramine; In Vitro Techniques; Mice; Nortriptyline; Reserpine; Serotonin; Tritium; Tryptamines | 1969 |
Effects of tricyclic antidepressants on the uptake and mabolism of intracisternally administered norepinephrine-H3 in rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cell Membrane; Cerebral Ventricles; Desipramine; Imipramine; Injections; Injections, Intraperitoneal; Male; Mitochondria; Norepinephrine; Normetanephrine; Nortriptyline; Rats; Tritium | 1969 |
[Separation and identification by thin-layer chromatography of 5 thymoanaleptic drugs derived from dibenzoazepine].
Topics: Antidepressive Agents; Chromatography, Thin Layer; Desipramine; Dibenzazepines; Imipramine; Opipramol | 1969 |
[On the absorption and metabolism of imipramine by the rat brain after single and repeated doses].
Topics: Animals; Brain; Brain Chemistry; Chromatography, Paper; Desipramine; Imipramine; Male; Methods; Rats | 1969 |
[Appearance of desmethylimipramine in rat brain following administration of imipramine as a function of the injection technic].
Topics: Animals; Brain; Desipramine; Imipramine; Injections, Intraperitoneal; Rats | 1969 |
An in vitro study of the effects of tricyclic antidepressant drugs on the accumulation of C14-serotonin by rabbit brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain Stem; Carbon Isotopes; Desipramine; Imipramine; In Vitro Techniques; Rabbits; Serotonin; Serotonin Antagonists | 1969 |
Interactions between guanethidine and inhibitors of noradrenaline uptake.
Topics: Animals; Desipramine; Drug Antagonism; Electric Stimulation; Guanethidine; Guinea Pigs; Imipramine; Male; Norepinephrine; Phenoxybenzamine; Vas Deferens | 1969 |
Use of antidepressant drugs during the first trimester.
Topics: Amitriptyline; Desipramine; Embryo, Mammalian; Female; Gestational Age; Humans; Imipramine; Nortriptyline; Pregnancy | 1969 |
Thin-layer chromatography of ion pairs on impregnated layers.
Topics: Alkaloids; Amitriptyline; Atropine; Chromatography, Thin Layer; Desipramine; Imipramine; Ions; Scopolamine | 1969 |
[A possible mechanism of disaggregation of ADP-induced aggregates by imipramin and structurally related compouds].
Topics: Adenine Nucleotides; Amitriptyline; Blood Platelets; Chlorpromazine; Desipramine; Diphenhydramine; Humans; Imipramine; Nortriptyline; Optical Rotatory Dispersion; Platelet Adhesiveness; Promazine; Promethazine | 1969 |
[Teratologic studies with imipramine in rats and rabbits. Planning and interpretation of teratologic studies under consideration of the biochemistry and toxicology of test substance].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Desipramine; Drug Tolerance; Embryo, Mammalian; Female; Fetal Death; Fetal Diseases; Hydrocephalus; Imipramine; Injections, Subcutaneous; Limb Deformities, Congenital; Pregnancy; Rabbits; Rats; Thalidomide | 1969 |
[Effect of thymoleptics on acid production of the stomach. Preliminary report].
Topics: Amitriptyline; Chlorpromazine; Depression; Depression, Chemical; Desipramine; Dibenzazepines; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Humans; Imipramine; Methotrimeprazine; Stomach; Tranquilizing Agents | 1969 |
[Cardiodepressive and local anesthetic effect of thymoleptics. Comparative studies with imipramine, desipramine, amitriptyline, nortriptyline and melitracene].
Topics: Amitriptyline; Anesthetics, Local; Animals; Anthracenes; Cornea; Depression, Chemical; Desipramine; Drug Synergism; Guinea Pigs; Heart Rate; Imipramine; In Vitro Techniques; Norepinephrine; Nortriptyline; Rabbits; Time Factors; Tyramine | 1969 |
[Thymoleptics and lipolysis].
Topics: Adipose Tissue; Amitriptyline; Animals; Antidepressive Agents; Cocaine; Depression, Chemical; Desipramine; Dibenzazepines; Fatty Acids, Nonesterified; Imipramine; In Vitro Techniques; Lipid Metabolism; Male; Norepinephrine; Nortriptyline; Photometry; Rats; Stimulation, Chemical; Tranquilizing Agents | 1969 |
Blockade of norepinephrine uptake by N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride in rodents.
Topics: Adipose Tissue; Adrenal Glands; Amines; Animals; Benzyl Compounds; Biological Transport; Brain; Brain Chemistry; Catecholamines; Catechols; Cell Membrane Permeability; Cyclohexanes; Desipramine; Epididymis; Fatty Acids, Nonesterified; Heart; Imipramine; Liver; Male; Metaraminol; Methylamines; Methyltransferases; Mice; Monoamine Oxidase; Myocardium; Naphthalenes; Neurons; Norepinephrine; Rats; Reserpine; Time Factors; Tritium; Tyrosine | 1969 |
Blockade of norepinephrine uptake and other activities of 5-(3'-dimethylaminopropyl)-dibenzo(a,d) (1,4)cycloheptadiene hydrochloride (AY-8794) and structurally related compounds.
Topics: Adipose Tissue; Amitriptyline; Animals; Anti-Inflammatory Agents; Biological Transport; Carrageenan; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Edema; Epididymis; Fatty Acids, Nonesterified; Female; Gastric Juice; Heart; Hindlimb; Imipramine; Injections, Intraperitoneal; Lipid Mobilization; Male; Mathematics; Mice; Myocardium; Norepinephrine; Rats; Time Factors; Tritium | 1969 |
Kinetic and thermodynamic considerations regarding the inhibition by tricyclic antidepressants of the uptake of tritiated norepinephrine by the adrenergic nerves in rabbit aortic strips.
Topics: Animals; Antidepressive Agents; Aorta; Desipramine; Energy Transfer; Female; Imipramine; Kinetics; Male; Muscle Contraction; Muscles; Neurons; Norepinephrine; Nortriptyline; Protein Binding; Rabbits; Sympathetic Nervous System; Tritium; Tyramine | 1970 |
[Current problems of endogenous depression].
Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Convulsive Therapy; Depression; Desipramine; Fluphenazine; Humans; Imipramine; Methotrimeprazine; Nortriptyline; Perphenazine; Thioridazine | 1970 |
A lung perfusion preparation for the study of drug metabolism.
Topics: Aminoisobutyric Acids; Animals; Centrifugation; Desipramine; Histamine; Hydrocortisone; Imipramine; Lung; Methods; Norepinephrine; Perfusion; Pharmaceutical Preparations; Pharmacology; Rabbits; Serotonin; Sulfanilamides; Vasoconstrictor Agents | 1970 |
[Clinical antidepressant drug therapy].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; Nortriptyline; Prognosis | 1970 |
Effects of psychotherapeutic drugs on hypothalamic- induced hissing in cats.
Topics: Amitriptyline; Animals; Cats; Chlordiazepoxide; Chlorpromazine; Desipramine; Electric Stimulation; Female; Hypothalamus; Imipramine; Injections, Intraperitoneal; Male; Pentobarbital; Perphenazine; Tranquilizing Agents; Trifluoperazine; Vocalization, Animal | 1970 |
Factors affecting the contractile responses of the rat vas deferens to cocaine and tetracaine.
Topics: Animals; Cocaine; Desipramine; Electric Stimulation; Glucose; Guanethidine; Hydrogen-Ion Concentration; Imipramine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxygen; Rats; Reserpine; Temperature; Tetracaine; Tyramine; Vas Deferens | 1970 |
The effect of pilocarpine in combination with monoamine oxidase inhibitors, imipramine or desmethylimipramine on oestrous behaviour in female rats.
Topics: Amines; Animals; Body Temperature; Castration; Central Nervous System; Desipramine; Drug Synergism; Estradiol; Estrus; Female; Hypothermia, Induced; Imipramine; Lordosis; Male; Motor Activity; Nialamide; Pargyline; Pilocarpine; Pregnancy; Progesterone; Rats; Sexual Behavior, Animal | 1970 |
Aggressive behaviour in chicks induced by tricyclic antidepressants.
Topics: Aggression; Animals; Behavior, Animal; Chickens; Desipramine; Dibenzazepines; Dibenzocycloheptenes; Female; Humans; Imipramine; Male; Motor Activity; Nortriptyline | 1970 |
[Therapy of imipramine poisoning in the child].
Topics: Child; Chloral Hydrate; Desipramine; Diuresis; Exchange Transfusion, Whole Blood; Humans; Imipramine; Male; Paraldehyde; Poisoning | 1970 |
A method for the measurement of plasma imipramine and desmethylimipramine concentrations.
Topics: Acetates; Animals; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry; Desipramine; Dogs; Imipramine; Methods; Methylation; Tritium | 1970 |
Inhibition of renal tubular transport of catecholamines by cocaine: an organic base mechanism.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Catecholamines; Chickens; Cocaine; Desipramine; Dibenzocycloheptenes; Dopamine; Epinephrine; Imipramine; Kidney Tubules; Models, Biological; Norepinephrine; Phenethylamines; Phenylacetates; Quaternary Ammonium Compounds; Renal Artery; Tyramine | 1970 |
Interactions of drugs with proteins. II. Experimental methods, treatment of experimental data, and thermodynamics of binding reactions of thymoleptic drugs and model dyes.
Topics: Antidepressive Agents; Binding Sites; Coloring Agents; Desipramine; Dialysis; Hydrogen-Ion Concentration; Imipramine; Mathematics; Methods; Models, Biological; Protein Binding; Serum Albumin, Bovine; Spectrophotometry; Ultracentrifugation; Ultraviolet Rays | 1970 |
Antianxiety and anti-depressant drugs.
Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Depression; Desipramine; Dibenzoxepins; Humans; Imipramine; Nortriptyline; Tranquilizing Agents | 1970 |
Antihemolytic actions of tricyclic tranquilizers. Structural correlations.
Topics: Animals; Cattle; Cell Membrane; Chemical Phenomena; Chemistry; Cholesterol; Desipramine; Dogs; Erythrocytes; Hemolysis; Imipramine; Male; Osmotic Fragility; Phenothiazines; Phosphatidylcholines; Protein Binding; Serum Albumin, Bovine; Sulfoxides; Tranquilizing Agents | 1970 |
Strain differences in the metabolism of imipramine by rat.
Topics: Amines; Aminopyrine; Aniline Compounds; Animals; Anisoles; Antipyrine; Body Temperature; Brain Chemistry; Desipramine; Dinitrophenols; Drug Antagonism; Female; Imipramine; Liver; Microsomes, Liver; Nitrophenols; Norepinephrine; Phenols; Rats; Reserpine; Species Specificity | 1970 |
Studies on the demethylation, hydroxylation and N-oxidation of imipramine in rat liver.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Chlorides; Chromatography, Paper; Dealkylation; Desipramine; Ethylamines; Imipramine; Liver; Magnesium; Male; Metabolism; Methylation; Oxidation-Reduction; Oxides; Phenobarbital; Proadifen; Rats; Valerates | 1970 |
Blockade of norepinephrine uptake and related activities of cis- and trans-N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride.
Topics: Adipose Tissue; Amines; Animals; Atropine; Chlorpromazine; Cyclohexanes; Desipramine; Drug Antagonism; Epididymis; Eyelids; Female; Hypnotics and Sedatives; Imipramine; Lacrimal Apparatus; Lipid Mobilization; Male; Mathematics; Metaraminol; Methyltyrosines; Mice; Motor Activity; Muscles; Myocardium; Naphthalenes; Norepinephrine; Rats; Species Specificity; Stereoisomerism; Tetrabenazine; Time Factors; Tremor; Tremorine; Tritium | 1970 |
Observation of the grooming behaviour of reserpinized white mice as a method for investigating reserpine antagonism and synergism.
Topics: Administration, Oral; Animals; Antidepressive Agents; Blepharoptosis; Charcoal; Desipramine; Dextroamphetamine; Dibenzazepines; Drug Synergism; Female; Grooming; Imipramine; Injections, Intravenous; Iproniazid; Methods; Mice; Nortriptyline; Propylamines; Reserpine | 1970 |
[Psychosensory phenomena during treatment with tricyclic thymoanaleptics (presentation of 2 cases)].
Topics: Depression; Desipramine; Female; Hallucinations; Humans; Imipramine; Male; Middle Aged; Tranquilizing Agents | 1970 |
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. I. Experiments in vivo and with isolated perfused livers.
Topics: Alcohols; Animals; Benzyl Compounds; Bile; Bile Acids and Salts; Biliary Fistula; Chromatography, Thin Layer; Desipramine; Glucuronates; Imines; Imipramine; Injections, Intravenous; Intestine, Small; Kinetics; Laparotomy; Liver; Male; Perfusion; Phenobarbital; Proadifen; Rats; Time Factors | 1970 |
Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. II. Uptake into bile micelles.
Topics: Alcohols; Animals; Bile; Bile Acids and Salts; Chemical Phenomena; Chemistry; Cholesterol; Colloids; Desipramine; Dialysis; Glucuronates; Imipramine; Macromolecular Substances; Male; Models, Biological; Molecular Weight; Phosphatidylcholines; Rats; Time Factors; Ultracentrifugation | 1970 |
Metabolism of 14 C-imipramine. 3. Conversions by rat tissues.
Topics: Animals; Autoradiography; Brain; Carbon Isotopes; Chromatography, Thin Layer; Desipramine; Female; Imines; Imipramine; In Vitro Techniques; Intestinal Mucosa; Kidney; Liver; Lung; Male; Myocardium; Rats; Toluene | 1970 |
Interactions of drugs with proteins. I. Binding of tricyclic thymoleptics to human and bovine plasma proteins.
Topics: Animals; Blood Proteins; Carbon Isotopes; Cattle; Desipramine; Dialysis; Humans; Imipramine; Kinetics; Mathematics; Models, Biological; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Tranquilizing Agents | 1970 |
[Intragastric telemetric pH measuring during thymoleptic therapy].
Topics: Amitriptyline; Depression; Depression, Chemical; Desipramine; Dibenzazepines; Female; Gastric Acidity Determination; Humans; Hydrogen-Ion Concentration; Imipramine; Male; Neurasthenia; Stimulation, Chemical; Telemetry; Tranquilizing Agents | 1970 |
Influence of iminodibencylic derivatives on the evoked potentials in the dorsal hippocampus of the rat.
Topics: Animals; Chlorpromazine; Depression, Chemical; Desipramine; Evoked Potentials; Hippocampus; Imipramine; Male; Rats; Stimulation, Chemical | 1970 |
Evidence concerning the effects of endogenous noradrenaline upon body temperature in cats and rabbits.
Topics: Animals; Body Temperature Regulation; Cats; Desipramine; Imipramine; Methyltyrosines; Norepinephrine; Rabbits | 1971 |
[Animal experiments to study the cardiotoxic effect of thymoleptics].
Topics: Amitriptyline; Animals; Blood Pressure; Cats; Desipramine; Drug Synergism; Epinephrine; Heart; Heart Failure; Humans; Imipramine; Nortriptyline; Tranquilizing Agents | 1971 |
The effect of various antidepressant drugs upon the tetrabenazine-suppressed conditioned avoidance response in rats.
Topics: Amphetamine; Animals; Antidepressive Agents; Avoidance Learning; Desipramine; Escape Reaction; Imipramine; Iproniazid; Male; Methylphenidate; Pargyline; Rats; Tetrabenazine | 1971 |
Inhibitory mechanism of imipramine on barbiturate metabolism in rat liver.
Topics: Animals; Barbiturates; Depression, Chemical; Desipramine; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Rats; Secobarbital; Thiopental | 1971 |
Concentrations of desipramine in the vas deferens and potentiation of noradrenaline response.
Topics: Animals; Cocaine; Denervation; Desipramine; Drug Synergism; Imipramine; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Ouabain; Rats; Temperature; Tritium; Vas Deferens | 1971 |
Effect of tricyclic antidepressants on monoamine responses of single cortical neurones.
Topics: Acetylcholine; Amines; Animals; Cats; Cerebral Cortex; Desipramine; Imipramine; Neurons; Norepinephrine; Serotonin; Serotonin Antagonists | 1971 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug Synergism; Female; Fever; Humans; Hypertension; Hypotension; Imipramine; Isocarboxazid; Male; Middle Aged; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Seizures | 1971 |
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.
Topics: Amphetamine; Animals; Animals, Newborn; Brain Chemistry; Chlorpromazine; Desipramine; Dopamine; Imipramine; Male; Metaraminol; Mixed Function Oxygenases; Neurons; Norepinephrine; Pargyline; Phenethylamines; Rats; Reserpine; Sodium Chloride; Tritium; Tyrosine | 1971 |
[Comparative clinical-experimental studies on imipramine and desipramine].
Topics: Blood Circulation; Blood Pressure; Depression; Desipramine; Drug Synergism; Heart; Humans; Imipramine; Norepinephrine; Pulse | 1967 |
Comparative study of imipramine, amitriptyline and their desmethyl analogues in the hypothyroid rat.
Topics: Amitriptyline; Animals; Blepharoptosis; Desipramine; Exploratory Behavior; Female; Hypothyroidism; Imipramine; Motor Activity; Nortriptyline; Posture; Propylthiouracil; Psychopharmacology; Rats; Sympathomimetics; Tetrabenazine | 1967 |
Mechanism of inhibition of experimental inflammation by antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Carrageenan; Catecholamines; Desipramine; Dextrans; Drug Synergism; Edema; Female; Formaldehyde; Imipramine; Nortriptyline; Rats | 1967 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |
[Treatment of Parkinsonian syndromes with two derivates of iminodibenzil: imipramine (tofranil) and desipramine (pertrofana)].
Topics: Aged; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Parkinson Disease | 1967 |
Effect of some antidepressive drugs on the blood pressure responses to the sympathomimetic amines.
Topics: Amphetamine; Animals; Blood Pressure; Blood Pressure Determination; Chlorides; Desipramine; Drug Synergism; Imipramine; Injections, Intraperitoneal; Male; Methods; Norepinephrine; Rats; Sulfates; Time Factors; Tyramine | 1967 |
[Nortriptyline poisoning].
Topics: Adult; Amitriptyline; Desipramine; Female; Humans; Imipramine; Nortriptyline | 1967 |
[Kinetics, intracellular localization and inducibility of monoamine oxidase].
Topics: Animals; Benzopyrenes; Desipramine; Enzyme Induction; Imipramine; Kinetics; Liver; Microsomes; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenobarbital; Polarography; Rabbits; Rats | 1967 |
Simple pharmacological procedures to differentiate antidepressants and cholinolytics in mice and rats.
Topics: Aggression; Animals; Antidepressive Agents; Atropine; Benactyzine; Desipramine; Exploratory Behavior; Female; Humans; Imipramine; Male; Methods; Mice; Motor Activity; Parasympatholytics; Rats; Reserpine | 1967 |
Pharmacological effects of a new antidepressant drug.
Topics: Animals; Antidepressive Agents; Cats; Desipramine; Dibenzocycloheptenes; Dogs; Guinea Pigs; Imipramine; Mice; Rats | 1967 |
[Comparative clinical experiences with dibenzazepine and dibenzodiazepine derivatives].
Topics: Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; Middle Aged; Schizophrenia | 1967 |
The relative effects of d-amphetamine, imipramine and harmaline on tetrabenazine suppression of schedule-controlled behavior in the rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Columbidae; Conditioning, Operant; Desipramine; Dextroamphetamine; Imipramine; Indoles; Male; Monoamine Oxidase Inhibitors; Picolines; Rats; Reaction Time; Reserpine; Tetrabenazine; Tranquilizing Agents | 1968 |
Inhibition by drugs of the accumulation in vitro of 5-hydroxytryptamine in guinea-pig vas deferens.
Topics: Amitriptyline; Animals; Antidepressive Agents; Carbon Isotopes; Chlorpromazine; Cocaine; Desipramine; Guinea Pigs; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Male; Serotonin; Vas Deferens | 1968 |
Tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Dibenzazepines; Enuresis; Humans; Imipramine; Nortriptyline; Opipramol | 1968 |
Inhibition of the metabolism of H3-melatonin by phenothiazines.
Topics: Amphetamine; Animals; Antimetabolites; Body Temperature; Brain; Chlorpromazine; Depression, Chemical; Desipramine; Female; Imipramine; Liver; Melatonin; Phenobarbital; Phenothiazines; Promazine; Promethazine; Rats; Tritium | 1968 |
The effect of various drug pretreatments on amine-induced phosphorylase activation and amine uptake.
Topics: Amitriptyline; Animals; Carbon Isotopes; Depression, Chemical; Desipramine; Diphenhydramine; Drug Synergism; Female; Glucosyltransferases; Heart; Imipramine; Isoproterenol; Methylphenidate; Myocardium; Norepinephrine; Promethazine; Propranolol; Rats; Stimulation, Chemical; Tranylcypromine; Triprolidine; Tritium; Tyramine | 1968 |
A new type of drug enhancement: increased maximum response to cumulative noradrenaline in the isolated rat vas deferens.
Topics: Amitriptyline; Animals; Cocaine; Desipramine; Drug Synergism; Imipramine; Male; Muscle Contraction; Norepinephrine; Phentolamine; Rats; Vas Deferens | 1968 |
[The effect of desmethylimipramine and other "anti-tremorine" drugs on the metabolism of tremorine and oxotremorine in rats and mice].
Topics: Animals; Body Temperature; Brain; Desipramine; Drug Synergism; Imipramine; Liver; Male; Malonates; Mice; Models, Biological; Proadifen; Pyrrolidines; Rats; Receptors, Drug; Species Specificity; Thermography; Tremor; Tremorine; Tritium | 1968 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Sodium Chloride; Solvents; Tranquilizing Agents | 1968 |
Placental transfer of desmethylimipramine.
Topics: Animals; Desipramine; Female; Fetus; Fluorometry; Imipramine; Injections, Intramuscular; Maternal-Fetal Exchange; Pregnancy; Rats; Spectrophotometry | 1968 |
[On the analgesic affect of thymoleptics].
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Codeine; Desipramine; Dibenzazepines; Humans; Imipramine; Male; Mice; Nortriptyline; Phosphates; Quinones; Tranquilizing Agents | 1968 |
[Investigation of gastric ulcer inhibiting and secreto-inhibitory actions of thymoleptics in rats].
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Gastric Juice; Imipramine; Nortriptyline; Rats; Stomach Ulcer | 1968 |
Enhancement of H3-norepinephrine accumulation in rat vas deferens by cocaine, imipramine, and desmethylimipramine.
Topics: Animals; Cocaine; Desipramine; Guanethidine; Imipramine; Male; Metaraminol; Myocardium; Norepinephrine; Rats; Reserpine; Stimulation, Chemical; Tritium; Vas Deferens | 1968 |
[On the characterization of the diffusion behavior of drugs with the "buccal absorption test"].
Topics: Absorption; Amines; Cheek; Desipramine; Diffusion; Humans; Hydrogen-Ion Concentration; Imipramine; Methods; Spectrophotometry; Toluene | 1968 |
On the metabolism of imipramine (Tofanil) in rat brain after single or repeated injections.
Topics: Animals; Brain; Desipramine; Imipramine; Injections, Intraperitoneal; Rats | 1968 |
Study on dosage variations of individual capsules and tablets of desipramine and imipramine hydrochloride.
Topics: Autoanalysis; Capsules; Desipramine; Imipramine; Spectrophotometry; Tablets; Ultraviolet Rays | 1968 |
[Response to psychotropic drugs in depressive syndromes. Clinico-statistical contribution].
Topics: Antidepressive Agents; Depression; Desipramine; Humans; Imipramine; Monoamine Oxidase Inhibitors | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine; Diazepam; Dibenzazepines; Drug Synergism; Ethanol; Humans; Imipramine; Methylphenidate; Mice; Nortriptyline; Phenelzine; Phenobarbital; Reflex; Substance-Related Disorders; Thioridazine; Tranquilizing Agents; Trifluoperazine | 1968 |
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compounds; Humans; Hypothermia; Imipramine; Male; Mice; Nicotine; Nicotinic Acids; Nitrophenols; Parasympatholytics; Parasympathomimetics; Phosphoric Acids; Pilocarpine; Pralidoxime Compounds; Scopolamine; Tremorine | 1968 |
Hypothermia following intraventricular injection of hemicholinium-3 in rats.
Topics: Acetylcholine; Amphetamine; Animals; Biphenyl Compounds; Body Temperature; Cerebral Ventricles; Choline; Desipramine; Hexamethonium Compounds; Imipramine; Male; Parasympatholytics; Phentolamine; Rats; Scopolamine | 1969 |
Clinical significance of anticholinergic effects of imipramine-like drugs.
Topics: Amitriptyline; Animals; Atropine; Columbidae; Depression; Desipramine; Diphenhydramine; Humans; Imipramine; Parasympatholytics; Scopolamine | 1969 |
Aryl-substituted triazines with antidepressant activity.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Drug Synergism; Electroshock; Hexobarbital; Imipramine; Mice; Reserpine; Sleep; Triazines | 1969 |
Cardiac abnormalities in poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography; Female; Heart; Humans; Imipramine; Nortriptyline | 1969 |
The effect of imipramine and desipramine on UDP-glucuronyltransferase.
Topics: Animals; Bilirubin; Desipramine; Glucosyltransferases; Guinea Pigs; Imipramine; In Vitro Techniques; Liver; Rats | 1969 |
The accumulation of C14-serotonin in the guinea-pig vas deferens.
Topics: Animals; Biological Transport, Active; Carbon Isotopes; Cocaine; Desipramine; Dopamine; Guinea Pigs; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Kinetics; Male; Microsomes; Mitochondria, Muscle; Norepinephrine; Ouabain; Reserpine; Serotonin; Temperature; Time Factors; Tryptamines; Tyramine; Vas Deferens | 1969 |
Effects of psychoactive drugs on the metabolism of intracisternally administered serotonin in rat brain.
Topics: Animals; Brain; Brain Chemistry; Carbon Isotopes; Cerebellum; Chlorpromazine; Desipramine; Ethers; Hypothalamus; Imipramine; Lysergic Acid Diethylamide; Medulla Oblongata; Mesencephalon; Norepinephrine; Pargyline; Pentobarbital; Pons; Rats; Reserpine; Serotonin; Tritium | 1969 |
Effects of centrally active drugs on four models of experimentally-induced aggregession in rodents.
Topics: Acridines; Aggression; Animals; Antidepressive Agents; Azepines; Chlordiazepoxide; Desipramine; Diazepam; Electrocoagulation; Electroshock; Ethers, Cyclic; Humans; Imipramine; Mice; Models, Biological; Rats; Rotation; Social Isolation; Thioridazine; Tranquilizing Agents | 1969 |
Desipramine and imipramine in an outpatient setting: a comparative study.
Topics: Adolescent; Adult; Depression; Desipramine; Humans; Imipramine; Middle Aged | 1965 |
Serotonin level in human and animal thrombocytes after imipramine and propazepine administration.
Topics: Absorption; Animals; Blood Platelets; Desipramine; Humans; Imipramine; Rabbits; Serotonin | 1965 |
A new antidepressant: desipramine hydrochloride (Norpramin, Pertofrane).
Topics: Adolescent; Aged; Animals; Child; Desipramine; Female; Humans; Imipramine; Pregnancy | 1965 |
Acute brain syndrome with florid psychosis from combined desipramine-imipramine therapy.
Topics: Brain Diseases; Desipramine; Humans; Imipramine; Psychoses, Substance-Induced | 1966 |
A method for recording the effect of drugs on the activity of small mammals over long periods of time.
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Desipramine; Hexobarbital; Hypnotics and Sedatives; Imipramine; Iproniazid; Meprobamate; Mice; Reserpine | 1966 |
The antagonism of oxotremorine effects in the mouse by thymoleptics.
Topics: Amphetamine; Animals; Desipramine; Drug Antagonism; Imipramine; Male; Mice; Proadifen; Tremorine; Trihexyphenidyl | 1966 |
Effect of amitriptyline and related drugs on neuromuscular transmission.
Topics: Amitriptyline; Animals; Anura; Cats; Desipramine; Diaphragm; Imipramine; In Vitro Techniques; Neostigmine; Neuromuscular Junction; Phrenic Nerve; Rats; Sciatic Nerve | 1966 |
[Amnesic action of some anti-depressive drugs and their effect on cerebral acetylcholine in the rat].
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Desipramine; Imipramine; Memory; Rats; Scopolamine | 1966 |
A neuropharmacological study of the antidepressant action of imipramine.
Topics: Animals; Blood Pressure; Cats; Cerebral Cortex; Desipramine; Dogs; Electric Stimulation; Electroencephalography; Imipramine; Reflex; Reticular Formation | 1966 |
Influence of various agonists and antagonists on the release of free fatty acids from adipose tissue in vitro.
Topics: Adipose Tissue; Animals; Chlorpromazine; Desipramine; Dextroamphetamine; Dopamine; Epididymis; Epinephrine; Fatty Acids; Imipramine; Isoproterenol; Male; Norepinephrine; Rats; Tyramine | 1966 |
The metabolism of imipramine and its metabolites by rat liver microsomes.
Topics: Alkylation; Animals; Buffers; Chromatography, Paper; Chromatography, Thin Layer; Desipramine; Formaldehyde; Glucosephosphate Dehydrogenase; Imipramine; Liver; Magnesium; Male; Microsomes; Oxidation-Reduction; Rats | 1966 |
Swimming performance of mice as affected by antidepressant drugs and baseline levels.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Deanol; Desipramine; Dextroamphetamine; Fatigue; Imipramine; Injections, Intraperitoneal; Iproniazid; Male; Mice; Phenelzine; Physical Exertion; Placebos; Swimming | 1966 |
[Psychopathological complications in antidepressant medication].
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Delirium; Depression; Desipramine; Dogs; Guinea Pigs; Humans; Imipramine; Mice; Movement; Rats; Tetrabenazine | 1966 |
[Amplification of the norepinephrine effect in man by psychopharmaca].
Topics: Amitriptyline; Blood Pressure; Desipramine; Electrocardiography; Electroencephalography; Humans; Imipramine; Isocarboxazid; Monoamine Oxidase Inhibitors; Norepinephrine; Thioridazine | 1966 |
[Therapeutic experiences in 5 clinics with a dibenzoxepine derivative in depressive states].
Topics: Amitriptyline; Depression; Desipramine; Dibenzothiepins; Dibenzoxepins; Humans; Imipramine; Monoamine Oxidase Inhibitors; Opipramol; Switzerland; Trimeprazine | 1966 |
[Comparative clinical experiences with Protriptyline in depressive conditions of various origins].
Topics: Amitriptyline; Antidepressive Agents; Depression; Desipramine; Dibenzazepines; Humans; Imipramine; Nortriptyline; Opipramol | 1966 |
Maze learning after the administration of antidepressant drugs.
Topics: Amphetamine; Animals; Antidepressive Agents; Ataxia; Behavior, Animal; Body Temperature Regulation; Deanol; Desipramine; Imipramine; Iproniazid; Learning; Male; Mice; Phenelzine; Swimming | 1967 |
Electron-microscopic localization of tritiated norepinephrine in rat brain: effect of drugs.
Topics: Animals; Autoradiography; Brain; Brain Chemistry; Caudate Nucleus; Desipramine; Dihydroxyphenylalanine; Hypothalamus; Imipramine; Injections, Intravenous; Microscopy, Electron; Norepinephrine; Rats; Reserpine; Tritium | 1967 |
The effects of psychoactive drugs on norepinephrine-3-H metabolism in brain.
Topics: Animals; Brain; Brain Chemistry; Chlorpromazine; Desipramine; Imipramine; Lithium; Norepinephrine; Normetanephrine; Rats | 1967 |
Interaction of imipramine and desmethylimipramine with tremorine and oxotremorine in mice.
Topics: Animals; Body Temperature; Desipramine; Dextroamphetamine; Imipramine; Lacrimal Apparatus; Male; Mice; Salivation; Scopolamine; Sweating; Tremorine | 1967 |
[Restraining action of antidepressive agents of the imipramine group on the cardiovascular centers].
Topics: Action Potentials; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Blood Pressure; Carotid Arteries; Cats; Desipramine; Hypertension; Hypothalamus; Imipramine; Medulla Oblongata; Mesencephalon; Nictitating Membrane; Nortriptyline; Rats; Sciatic Nerve; Splanchnic Nerves | 1967 |
Plasma levels of imipramine and desmethylimipramine during therapy.
Topics: Adult; Aged; Chromatography; Chromatography, Thin Layer; Desipramine; Female; Humans; Imipramine; Male; Mental Disorders; Middle Aged | 1967 |
Central anticholinergic activity of imipramine and allied drugs.
Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Female; Imipramine; Male; Mice; Parasympatholytics; Seizures | 1967 |
Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds.
Topics: Adult; Amitriptyline; Desipramine; Female; Humans; Imipramine; Male; Nortriptyline | 1967 |
[Clinical studies of a new antidepressive agent, nortriptyline].
Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Desipramine; Humans; Imipramine; Middle Aged; Neurotic Disorders; Nortriptyline | 1967 |
Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
Topics: Aging; Animals; Carrier Proteins; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Preoptic Area; Rats; Receptors, Drug; Receptors, Neurotransmitter | 1984 |
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine | 1980 |
Dexamethasone suppression test identifies subtypes of depression which respond to different antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depression; Depression, Chemical; Desipramine; Dexamethasone; Diagnosis, Differential; Female; Humans; Imipramine; Male; Pituitary-Adrenal System | 1980 |
Affinity of butriptyline and other tricyclic antidepressants for alpha-adrenoceptor binding sites in rat brain.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Binding, Competitive; Brain; Desipramine; Dibenzocycloheptenes; Imipramine; In Vitro Techniques; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Depression in childhood: a biopsychosocial perspective.
Topics: Adult; Child; Depressive Disorder; Desipramine; Diagnosis, Differential; Humans; Imipramine; Neurotransmitter Agents; Psychotherapy; Social Environment | 1981 |
Suppression of histamine-induced adrenocorticotropic hormone release by antihistamines and antidepressants.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents; Desipramine; Diazepam; Doxepin; Histamine; Histamine H1 Antagonists; Imipramine; Iprindole; Male; Mianserin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Histamine; Stimulation, Chemical | 1982 |
The route of administration of imipramine as a factor affecting formation of its metabolite desipramine.
Topics: Administration, Oral; Animals; Desipramine; Imipramine; Injections, Intraperitoneal; Kinetics; Male; Rats; Rats, Inbred Strains | 1982 |
Drug-specific EEG frequency spectra and their time courses produced in the cat by antidepressants and a benzodiazepine.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cats; Desipramine; Diazepam; Dose-Response Relationship, Drug; Doxepin; Electroencephalography; Female; Imipramine | 1981 |
Active metabolites of antidepressants: pharmacodynamics and relevant pharmacokinetics.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Asian People; Biotransformation; Clonidine; Desipramine; Female; Humans; Hydroxyindoleacetic Acid; Imipramine; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Serotonin; Structure-Activity Relationship; White People | 1984 |
Characterization of typical and atypical antidepressant recognition sites in rat brain.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Brain; Carrier Proteins; Desipramine; Fenclonine; Imipramine; Mianserin; Neurons; Rats; Receptors, Drug; Serotonin | 1982 |
Attenuation of the post-decapitation convulsions after repeated treatment of rats with desipramine, imipramine and maprotiline.
Topics: Alanine; Animals; Anticonvulsants; Antidepressive Agents; Desipramine; Imipramine; Male; Maprotiline; Rats; Rats, Inbred Strains; Time Factors; Zimeldine | 1984 |
Interactions of tricyclic antidepressants with a synaptic ion channel.
Topics: Acetylcholine; Amitriptyline; Amphibian Venoms; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Desipramine; Electric Organ; Fishes; Imipramine; Ion Channels; Nortriptyline; Phencyclidine; Receptors, Nicotinic | 1981 |
Brain serotonin receptors and neuropsychiatric disorders.
Topics: Animals; Brain; Desipramine; Fluoxetine; Humans; Imipramine; Kinetics; Lysergic Acid Diethylamide; Mental Disorders; Organ Specificity; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Serotonin; Schizophrenia; Serotonin | 1981 |
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
Topics: Animals; Cells, Cultured; Desipramine; Fibroblasts; Humans; Imipramine; Mice; Neuroblastoma; Phosphoric Diester Hydrolases; Skin; Sphingomyelin Phosphodiesterase | 1981 |
Sensitivity in vivo of central alpha 2- and opiate receptors after chronic treatment with various antidepressants.
Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpromazine; Clomipramine; Clonidine; Desipramine; Evoked Potentials; Imipramine; Iprindole; Locus Coeruleus; Male; Mianserin; Morphine; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Zimeldine | 1982 |
Evidence for stabilization of cortical 5HT neurotransmission by chronic treatment with antidepressant drugs: induction of a high and low affinity component in 3H-5HT binding sites.
Topics: Animals; Antidepressive Agents; Binding Sites; Brompheniramine; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Tritium; Zimeldine | 1982 |
Chronic treatment with imipramine: further functional evidence for the enhanced noradrenergic transmission in flexor reflex activity.
Topics: Animals; Desipramine; Hindlimb; Imipramine; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex; Spinal Cord; Synaptic Transmission | 1983 |
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Culture Techniques; Desipramine; Dose-Response Relationship, Drug; Enzymes; Glioma; Imipramine; Neoplasms, Experimental; Phosphoric Diester Hydrolases; Rats; Sphingolipids; Sphingomyelin Phosphodiesterase | 1983 |
The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats.
Topics: Animals; Desipramine; Escape Reaction; Helplessness, Learned; Humans; Imipramine; Isoquinolines; Male; Nomifensine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Adrenergic; Receptors, Dopamine | 1983 |
beta-Adrenergic receptor regulation and antidepressants: the influence of adrenocorticotropin.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Cerebral Cortex; Cyclic AMP; Desipramine; Dihydroalprenolol; Hydroxydopamines; Imipramine; Male; Mianserin; Oxidopamine; Pargyline; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1983 |
Antidepressant binding: implications for the mode of action and the biology of depression.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cerebral Cortex; Depressive Disorder; Desipramine; Hippocampus; Humans; Imipramine; Kinetics; Norepinephrine; Rats; Receptors, Drug; Receptors, Neurotransmitter; Serotonin; Synaptosomes | 1983 |
Criteria for receptor sites in binding studies.
Topics: Animals; Astemizole; Benzimidazoles; Binding Sites; Cell Membrane; Desipramine; Humans; Imipramine; Radioligand Assay; Receptors, Cell Surface; Receptors, Drug; Serotonin; Synaptic Transmission | 1984 |
Pharmacological studies on the antagonism by antidepressants of the hypothermia induced by apomorphine.
Topics: Animals; Antidepressive Agents; Apomorphine; Body Temperature; Catecholamines; Desipramine; Drug Tolerance; Imipramine; Male; Mice; Quipazine; Receptors, Adrenergic; Receptors, Catecholamine | 1984 |
Electrophysiological effects of cocaine in the rat hippocampus in vitro.
Topics: Animals; Cocaine; Culture Techniques; Desipramine; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Imipramine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission | 1984 |
Comparison of pharmacological treatment response between situational and non-situational depressions.
Topics: Amitriptyline; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Life Change Events; Lithium; Lithium Carbonate; Male; Time Factors | 1984 |
Quantification of imipramine and its major metabolites in whole blood, brain, and other tissues of the rat by liquid chromatography.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Female; Fetus; Imipramine; Pregnancy; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat.
Topics: Animals; Brain; Desipramine; Erythrocytes; Female; Imipramine; Kinetics; Male; Pregnancy; Rats; Rats, Inbred Strains; Time Factors | 1984 |
The effect of imipramine and desipramine on mixed function oxidase in rats.
Topics: Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Desipramine; Imipramine; In Vitro Techniques; Liver; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Rats; Rats, Inbred Strains | 1984 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Fluvoxamine; Imipramine; Male; Maprotiline; Mianserin; Oximes; Rats; Rats, Inbred Strains; Seizures; Viloxazine | 1984 |
Role of imipramine & desipramine in counteracting diazepam induced changes of adenosinetriphosphatase & cholinesterase of human fetal brain.
Topics: Adenosine Triphosphatases; Brain; Cholinesterases; Desipramine; Diazepam; Female; Fetus; Gestational Age; Humans; Imipramine; Pregnancy | 1981 |
Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Desipramine; Dogs; Drug Interactions; Epinephrine; Female; Halothane; Heart Rate; Imipramine; Norepinephrine; Phenylephrine | 1984 |
Effect of tricyclic antidepressant drugs on lymphocyte membrane structure.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Membrane; Cells, Cultured; Desipramine; Dose-Response Relationship, Drug; Fluorescent Dyes; Imipramine; Lymphocytes; Male; Mice; Nortriptyline; Protriptyline; Spleen; Temperature; Time Factors | 1984 |
The complex binding of tricyclic antidepressants to rat brain: the case of nortriptyline.
Topics: Animals; Autoradiography; Binding Sites; Brain; Desipramine; Imipramine; Nortriptyline; Rats | 1984 |
Serum imipramine concentrations lower than plasma values.
Topics: Adult; Aged; Blood Specimen Collection; Chromatography, High Pressure Liquid; Depressive Disorder; Desipramine; Humans; Imipramine; Male; Middle Aged; Plasma | 1984 |
Efficacy and feasibility of high dose tricyclic antidepressant treatment in elderly delusional depressives.
Topics: Aged; Antidepressive Agents, Tricyclic; Delusions; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged | 1984 |
Monitoring of serum levels of imipramine and desipramine and individualization of dose in enuretic children.
Topics: Adolescent; Child; Child, Preschool; Desipramine; Drug Administration Schedule; Enuresis; Female; Humans; Imipramine; Kinetics; Male; Patient Compliance | 1984 |
Blood collection tubes for tricyclic antidepressant drugs: a reevaluation.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Preservation; Blood Proteins; Blood Specimen Collection; Desipramine; Humans; Imipramine; Nortriptyline; Plasma | 1984 |
Monitoring compliance through analysis of drug and metabolite levels.
Topics: Anti-Inflammatory Agents; Antidepressive Agents; Biotransformation; Desipramine; Humans; Imipramine; Patient Compliance; Pharmaceutical Preparations; Pilocarpine | 1984 |
Concentrations of imipramine and its metabolites during enuresis therapy.
Topics: Adolescent; Child; Desipramine; Enuresis; Female; Humans; Imipramine; Male | 1984 |
High-performance liquid chromatographic determination of imipramine and desipramine in human serum.
Topics: Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Humans; Imipramine | 1984 |
Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomipramine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline | 1984 |
Facial EMG activity levels predict treatment outcome in depression.
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Electromyography; Facial Expression; Facial Muscles; Female; Humans; Imipramine; Maprotiline; Middle Aged; Muscle Contraction; Prognosis; Psychiatric Status Rating Scales | 1984 |
Pharmacokinetics of imipramine after single and multiple intravenous administration in rats.
Topics: Animals; Brain Chemistry; Desipramine; Imipramine; Injections, Intravenous; Kinetics; Male; Rats; Rats, Inbred Strains | 1983 |
Plasma levels of imipramine and adverse effects in children.
Topics: Blood Pressure; Child; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Imipramine; Male | 1983 |
Anorgasmia associated with imipramine but not desipramine: case report.
Topics: Desipramine; Female; Humans; Imipramine; Middle Aged; Orgasm; Serotonin; Sexual Dysfunctions, Psychological | 1983 |
Changes in visual evoked potentials induced by imipramine in patients with endogenous depression.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Evoked Potentials, Visual; Female; Humans; Imipramine; Male; Middle Aged | 1983 |
Panic disorder.
Topics: Adolescent; Adult; Anxiety Disorders; Desipramine; Diagnosis, Differential; Family Practice; Fear; Female; Humans; Imipramine; Life Change Events; Male; Panic | 1983 |
Phenytoin: similarity to tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlordiazepoxide; Conditioning, Operant; Cues; Desipramine; Discrimination Learning; Imipramine; Male; Pentobarbital; Phenytoin; Rats; Rats, Inbred Strains | 1983 |
Liquid chromatographic separation of antidepressant drugs: I. Tricyclics.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Promazine; Protriptyline | 1983 |
Thin-layer chromatographic determination of imipramine and desipramine in human plasma and urine at single-dose levels.
Topics: Adult; Chromatography, Thin Layer; Desipramine; Half-Life; Humans; Imipramine; Kinetics; Male; Models, Biological | 1983 |
The production in high yield of N'-(4-[11C]methyl)-imipramine.
Topics: Carbon Radioisotopes; Chromatography, High Pressure Liquid; Desipramine; Dimethyl Sulfoxide; Hydrocarbons, Iodinated; Imipramine; Isotope Labeling; Quality Control | 1983 |
Discriminative stimulus control with imipramine: transfer to other anti-depressants.
Topics: Amitriptyline; Animals; Behavior, Animal; Desipramine; Discrimination Learning; Imipramine; Male; Rats; Rats, Inbred Strains | 1983 |
Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine.
Topics: Animals; Chemical Phenomena; Chemistry; Desipramine; Gas Chromatography-Mass Spectrometry; Imipramine; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Rabbits | 1983 |
Effects of a new antidepressant drug on active avoidance behavior in rats. Comparative study with tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Avoidance Learning; Desipramine; Extinction, Psychological; Female; Imipramine; Male; Piperazines; Rats | 1983 |
Drug therapy of anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Depressive Disorder; Desipramine; Female; Humans; Imipramine | 1983 |
Influence of the antidepressant binodaline on biogenic amine uptake and brain levels in the rat.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Brain Chemistry; Desipramine; Dopamine; Imipramine; Indoles; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1983 |
Cimetidine interaction with imipramine and nortriptyline.
Topics: Adult; Biological Availability; Cimetidine; Desipramine; Drug Interactions; Humans; Imipramine; Kinetics; Male; Nortriptyline | 1984 |
Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Desipramine; Electrocardiography; Electrophysiology; Female; Follow-Up Studies; Heart Conduction System; Heart Ventricles; Humans; Imipramine; Male; Middle Aged; Tachycardia | 1984 |
Seminal emission induced by tricyclic antidepressant.
Topics: Anxiety Disorders; Defecation; Depressive Disorder; Desipramine; Double-Blind Method; Ejaculation; Humans; Imipramine; Male; Middle Aged; Placebos | 1984 |
Urinary 3-methoxy-4-hydroxyphenylglycol and major affective disorders. A replication and new findings.
Topics: Adult; Bipolar Disorder; Circadian Rhythm; Depressive Disorder; Desipramine; Female; Glycols; Humans; Imipramine; Male; Methoxyhydroxyphenylglycol; Middle Aged; Sex Factors | 1984 |
The relationship of plasma imipramine and N-desmethylimipramine to improvement in agoraphobia.
Topics: Agoraphobia; Desipramine; Humans; Imipramine; Phobic Disorders | 1984 |
Boy with seriously ill mother manifests somatic complaints, withdrawal, disabling fears.
Topics: Adjustment Disorders; Child; Child Reactive Disorders; Combined Modality Therapy; Desipramine; Family Therapy; Humans; Imipramine; Male; Maternal Deprivation; Patient Care Planning; Phobic Disorders; Somatoform Disorders | 1984 |
Effects of desipramine, trifluoperazine and other inhibitors of calmodulin on the secretion of catecholamines from the adrenal medulla and postganglionic sympathetic nerves of the salivary gland.
Topics: Acetylcholine; Adrenal Medulla; Animals; Calcium; Calmodulin; Catecholamines; Desipramine; Electric Stimulation; Imipramine; In Vitro Techniques; Male; Norepinephrine; Perfusion; Rats; Salivary Glands; Splanchnic Nerves; Trifluoperazine | 1984 |
Elevated plasma tricyclic levels with therapeutic doses of imipramine.
Topics: Adult; Depressive Disorder; Desipramine; Electrocardiography; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged; Sex Factors; Xerostomia | 1984 |
Lactate provocation of panic attacks. I. Clinical and behavioral findings.
Topics: Adult; Agoraphobia; Anxiety Disorders; Clonidine; Desipramine; Fear; Female; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic | 1984 |
3H-imipramine and 3H-cyano-imipramine binding in rat brain tissue: effect of long-term antidepressant administration.
Topics: Animals; Binding Sites; Brain; Desipramine; Female; Imipramine; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo.
Topics: Animals; Brain; Desipramine; Dopamine; Imipramine; Injections, Intraventricular; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution | 1984 |
Norepinephrine uptake inhibitors as biochemically and behaviorally selective antagonists of the locomotor stimulation induced by indirectly acting sympathomimetic aminetic amines in mice.
Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; Dextroamphetamine; Humans; Imipramine; Male; Mice; Motor Activity; Norepinephrine; Stereotyped Behavior; Sympathomimetics | 1980 |
Comparison of single-dose pharmacokinetics of imipramine and maprotiline in the elderly.
Topics: Aged; Anthracenes; Biological Availability; Desipramine; Female; Half-Life; Hemodynamics; Humans; Imipramine; Kinetics; Maprotiline | 1980 |
Endogenous depression and imipramine levels in the blood.
Topics: Adult; Aged; Depression; Desipramine; Female; Humans; Imipramine; Kinetics; Male; Middle Aged; Psychiatric Status Rating Scales | 1980 |
Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester.
Topics: Desipramine; Drug Stability; Humans; Imipramine; In Vitro Techniques; Male; Phorbol Esters; Phorbols; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Serotonin; Thromboxane B2 | 1981 |
A comparison of plasma and serum levels of two tricyclic antidepressants: imipramine and desipramine.
Topics: Blood Chemical Analysis; Desipramine; Humans; Imipramine; Plasma | 1981 |
Therapeutic use of the tricyclic-induced switch in bipolar manic-depression.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Desipramine; Drug Therapy, Combination; Humans; Imipramine; Lithium; Lithium Carbonate; Male | 1982 |
DSP4-induced two-way active avoidance impairment in rats: involvement of central and not peripheral noradrenaline depletion.
Topics: Amines; Animals; Avoidance Learning; Benzylamines; Brain; Cerebellum; Cerebral Cortex; Desipramine; Escape Reaction; Hippocampus; Imipramine; Limbic System; Male; Motor Activity; Neurons; Neurotoxins; Norepinephrine; Peripheral Nerves; Rats; Rats, Inbred Strains | 1982 |
The dexamethasone suppression test in depressive illness: clinical correlates.
Topics: Depressive Disorder; Desipramine; Dexamethasone; Diagnosis, Differential; Double-Blind Method; Doxepin; Electroconvulsive Therapy; Female; Humans; Hydrocortisone; Imipramine; Male; Mianserin; Middle Aged; Nortriptyline; Phenelzine; Psychiatric Status Rating Scales; Selegiline | 1982 |
Column deactivation in analysis for underivatized tricyclic antidepressants by gas chromatography with use of a nitrogen detector.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Humans; Imipramine; Nitrogen; Nortriptyline | 1983 |
Imipramine metabolites in blood of patients during therapy and after overdose.
Topics: Adult; Aged; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged | 1983 |
Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers.
Topics: Amitriptyline; Animals; Binding, Competitive; Cerebral Cortex; Clomipramine; Desipramine; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists | 1983 |
Cimetidine-imipramine interaction: a case report.
Topics: Adult; Cimetidine; Depressive Disorder; Desipramine; Drug Interactions; Female; Guanidines; Half-Life; Humans; Imipramine; Metabolic Clearance Rate | 1983 |
alpha 1-acid glycoprotein involvement in high affinity binding of tricyclic antidepressants to human plasma.
Topics: Antidepressive Agents, Tricyclic; Binding Sites; Desipramine; Humans; Imipramine; Orosomucoid; Protein Binding; Serum Albumin | 1983 |
The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Desipramine; Emotions; Humans; Imipramine; Methylphenidate; Middle Aged; Norepinephrine; Nortriptyline | 1983 |
Age as a predictor of treatment response in endogenous depression.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans; Imipramine; Male; Middle Aged | 1983 |
Antiarrhythmic plasma-concentration range of imipramine against ventricular premature depolarizations.
Topics: Adult; Aged; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Half-Life; Heart Ventricles; Humans; Imipramine; Male; Middle Aged; Time Factors | 1983 |
Role of serotonin in the blockade of muricidal behavior by tricyclic antidepressants.
Topics: Aggression; Amitriptyline; Amphetamines; Animals; Desipramine; Diet; Humans; Imipramine; Male; Mice; p-Chloroamphetamine; Rats; Serotonin; Tryptophan | 1982 |
Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats.
Topics: Animals; Bile; Biotransformation; Chromatography, Thin Layer; Desipramine; Female; Imipramine; Oxidation-Reduction; Pregnenolone Carbonitrile; Rats | 1982 |
Failure of physostigmine in intoxications with tricyclic antidepressants in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Atropine; Clomipramine; Desipramine; Drug Interactions; Female; Heart Rate; Imipramine; Lethal Dose 50; Physostigmine; Rats; Rats, Inbred Strains; Respiration; Time Factors | 1982 |
On the kinetics of imipramine and related antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Desipramine; Half-Life; Humans; Imipramine; Kinetics; Rats | 1980 |
Pituitary-adrenal disinhibition in depression: marker of a subtype with characteristic clinical features and response to treatment?
Topics: Adult; Amitriptyline; Clomipramine; Depressive Disorder; Desipramine; Dexamethasone; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Pituitary-Adrenal System; Recurrence | 1981 |
Tricyclic antidepressants do not alter thyroid hormone levels in patients suffering from a major affective disorder.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Thyroid Hormones; Thyroxine; Triiodothyronine | 1981 |
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.
Topics: Albuterol; Animals; Clonidine; Desipramine; Drug Interactions; Exploratory Behavior; Fluoxetine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Yohimbine | 1982 |
The uptake of 14C-chloroquine by mouse pancreatic islets in vitro.
Topics: Absorption; Animals; Chloroquine; Chlorpromazine; Desipramine; Glucose; Hydrogen-Ion Concentration; Imipramine; Islets of Langerhans; Lidocaine; Mice; Nicotine; Nitrogen; Ouabain; Quinacrine; Temperature | 1980 |
Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales; Thyroxine; Triiodothyronine | 1982 |
Plasma concentrations of tricyclic antidepressants in clinical practice.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Nortriptyline | 1982 |
Active metabolites of imipramine and desipramine in man.
Topics: Adolescent; Adult; Aged; Biotransformation; Child; Desipramine; Double-Blind Method; Enuresis; Female; Humans; Imipramine; Male; Middle Aged | 1982 |
High-affinity binding of [3H]desipramine to rat brain: a presynaptic marker for noradrenergic uptake sites.
Topics: Animals; Binding Sites; Binding, Competitive; Biological Transport; Brain; Cell Membrane; Desipramine; Hydroxydopamines; Imipramine; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Tissue Distribution | 1982 |
Steady-state plasma imipramine levels in prepubertal depressed children.
Topics: Age Factors; Body Height; Body Weight; Child; Depressive Disorder; Desipramine; Humans; Imipramine; Male | 1982 |
Tricyclic antidepressants and cardiac patients with pacemakers.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Heart Rate; Humans; Imipramine; Male; Nortriptyline; Pacemaker, Artificial; Sick Sinus Syndrome | 1982 |
Sex differences in the uptake and retention of imipramine and desmethylimipramine in the rat lung.
Topics: Animals; Desipramine; Female; Imipramine; Lung; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred Strains; Sex Factors | 1982 |
Tricyclic antidepressant plasma levels: the state of the art and clinical prospects.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Bipolar Disorder; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Imipramine; Nortriptyline | 1982 |
Imipramine kinetics in the single pass rat liver perfusion model.
Topics: Animals; Desipramine; Female; Imipramine; Kinetics; Liver; Models, Biological; Perfusion; Rats; Rats, Inbred Strains | 1982 |
TCA-induced mania: differences between switchers and nonswitchers.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Protriptyline | 1982 |
[3H]Desipramine and [3H]imipramine binding are not associated with noradrenaline and serotonin uptake in the brain.
Topics: Animals; Brain; Desipramine; Imipramine; In Vitro Techniques; Nerve Tissue Proteins; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Subcellular Fractions | 1982 |
Simultaneous analysis of imipramine and its metabolite desipramine in biological fluids.
Topics: Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Reference Values | 1982 |
GLC method for iminodibenzyl and desipramine impurities in imipramine hydrochloride and its formulated products.
Topics: Amines; Benzylamines; Chromatography, Gas; Desipramine; Drug Contamination; Drug Stability; Imipramine; Solutions; Tablets | 1982 |
Inhibition of foot intake in the rat.
Topics: Animals; Antidepressive Agents; Appetite Depressants; Desipramine; Diazepam; Eating; Haloperidol; Imipramine; Male; Nomifensine; Rats; Rats, Inbred Strains | 1982 |
Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Desipramine; Imipramine; Kinetics; Neurons; Norepinephrine; Potassium; Rats; Tissue Distribution | 1982 |
Study of the metabolic conversion of imipramine and desipramine to N-nitrosodesipramine by bacteria using a nitrogen-selective GC analysis.
Topics: Aerobiosis; Anaerobiosis; Animals; Bacteria; Biotransformation; Chromatography, Gas; Desipramine; Imipramine; In Vitro Techniques; Intestines; Male; Rats; Rats, Inbred Strains | 1982 |
Different pharmacokinetic and pharmacological effects following acute and chronic treatment with imipramine.
Topics: Animals; Brain Chemistry; Desipramine; Fenfluramine; Fever; Imipramine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1982 |
Autoradiographic demonstration of binding sites for [3H]desipramine in rat brain.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Desipramine; Female; Imipramine; Rats; Rats, Inbred Strains; Receptors, Drug | 1982 |
Bonded-phase extraction of plasma tricyclic antidepressant drugs for gas chromatographic analysis.
Topics: Acetates; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Desipramine; Humans; Imipramine; Methods; Nortriptyline | 1982 |
The electrocardiographic and anticholinergic effects of trazodone and imipramine in man.
Topics: Adult; Desipramine; Electrocardiography; Humans; Imipramine; Male; Parasympatholytics; Piperazines; Salivation; Time Factors; Trazodone | 1982 |
[Comparative studies of the nitrosation behavior of drugs by constant pH value and under simulated stomach conditions].
Topics: Aminopyrine; Ampicillin; Biotransformation; Clomipramine; Desipramine; Dipyrone; Ethambutol; Gastric Acidity Determination; Gastric Mucosa; Humans; Imipramine; Neoplasms; Nitrites; Nitroso Compounds; Oxacillin; Penicillins; Piperazines | 1982 |
Depression in children: relationship between plasma imipramine levels and response.
Topics: Age Factors; Child; Depressive Disorder; Desipramine; Female; Hospitalization; Humans; Imipramine; Male; Psychiatric Status Rating Scales | 1982 |
The relationship of therapeutic response to antidepressant plasma levels: an update.
Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Biological Availability; Depressive Disorder; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Patient Compliance; Protriptyline | 1982 |
Evidence for in vivo methylation of the secondary amino antidepressant desipramine to imipramine in humans.
Topics: Amitriptyline; Biotransformation; Depressive Disorder; Desipramine; Humans; Imipramine; Methylation; Nortriptyline | 1982 |
[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA].
Topics: Animals; Antidepressive Agents; Brain; Carbazoles; Carbolines; Clomipramine; Depression, Chemical; Desipramine; gamma-Aminobutyric Acid; Imipramine; In Vitro Techniques; Oxazines; Piperazines; Rats; Serotonin; Synaptosomes; Trazodone | 1981 |
Excessive plasma concentration of tricyclic antidepressants resulting from usual doses: a report of six cases.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Liver Cirrhosis, Alcoholic; Male; Middle Aged | 1981 |
Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline | 1981 |
An enhanced sensitivity of muscarinic cholinergic receptor associated with dopaminergic receptor subsensitivity after chronic antidepressant treatment.
Topics: Animals; Corpus Striatum; Desipramine; Imipramine; Kinetics; Male; Quinuclidinyl Benzilate; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Muscarinic; Spiperone; Tritium | 1981 |
The dexamethasone suppression test in the identification subtypes of depression differentially responsive to antidepressants [proceedings].
Topics: Adult; Age Factors; Aged; Amitriptyline; Clomipramine; Depressive Disorder; Desipramine; Dexamethasone; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Radioimmunoassay; Statistics as Topic | 1981 |
Blockade by imipramine or desipramine of panic induced by sodium lactate.
Topics: Anxiety Disorders; Desipramine; Fear; Humans; Imipramine; Lactates; Panic | 1981 |
Liquid-chromatographic analysis for common tricyclic antidepressant drugs and their metabolites in serum or plasma with the technicon "FAST-LC" system.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline; Protriptyline | 1981 |
'High affinity' binding of [3H]desipramine to rat cerebral cortex: relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake.
Topics: Animals; Binding Sites; Biological Transport; Cerebral Cortex; Desipramine; Imipramine; Norepinephrine; Rats; Serotonin; Structure-Activity Relationship; Synaptic Membranes | 1981 |
The clinical characteristics and treatment of atypical depression.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Desipramine; Fatigue; Female; Humans; Imipramine; Male; Middle Aged | 1981 |
Simultaneous determination of imipramine, desipramine, and their 2-hydroxy metabolites in plasma by ion-pair reversed-phase high-performance liquid chromatography with amperometric detection.
Topics: Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Humans; Hydroxylation; Imipramine | 1981 |
Influence of a chronic new potential antidepressant, 1-[3-(dimethylamino)propyl]-5-methyl-3-phenyl-1H-indazole(FS32) and its N-desmethylated compound(FS97): treatment on monoaminergic receptor sensitivity in the rat brain.
Topics: Animals; Binding Sites; Brain; Desipramine; Imipramine; Indazoles; Male; Pyrazoles; Rats; Receptors, Dopamine; Receptors, Serotonin | 1981 |
The depression-pain syndrome and its response to antidepressants.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Middle Aged; Pain; Syndrome | 1981 |
Plasma concentration monitoring of hydroxylated metabolites of imipramine and desipramine.
Topics: Adolescent; Adult; Aged; Biotransformation; Brain; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged; Monitoring, Physiologic | 1981 |
[Correlation between antidepressant membrane affinity and their effects on neuromediator reuptake].
Topics: Affinity Labels; Antidepressive Agents; Carbazoles; Clomipramine; Desipramine; Imipramine; Liposomes; Membrane Lipids; Phospholipids; Piperazines | 1981 |
Reversed-phase liquid chromatography and gas chromatography/mass fragmentography compared for determination of tricyclic antidepressant drugs.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Nortriptyline | 1981 |
Tricyclic antidepressant blood levels: eight practical questions.
Topics: Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Intestinal Absorption; Nortriptyline | 1981 |
Quantitative mapping of metabolites of imipramine and desipramine in plasma samples by gas chromatographic-mass spectrometry.
Topics: Biotransformation; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine | 1981 |
Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Synaptosomes; Viloxazine | 1981 |
Cerebral pharmacokinetics of imipramine in rats after single and multiple dosages.
Topics: Animals; Biotransformation; Brain; Desipramine; Drug Administration Schedule; Imipramine; Kinetics; Male; Rats; Rats, Inbred Strains | 1981 |
The diagnosis and treatment of hidden depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Desipramine; Diagnosis, Differential; Female; Humans; Imipramine; Male; Psychotherapy; Social Isolation | 1981 |
Pharmacological characterization of [3H] desipramine binding in rat cerebral cortex.
Topics: Animals; Binding Sites; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Tritium | 1981 |
Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats.
Topics: Animals; Blepharoptosis; Desipramine; Hypothermia; Imipramine; Male; Motor Activity; Proadifen; Rats; Rats, Inbred Strains; Reserpine | 1981 |
Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding.
Topics: Animals; Antidepressive Agents, Tricyclic; Binding Sites; Brain; Desipramine; Drug Interactions; Imipramine; Kinetics; Male; Rats; Tissue Distribution | 1980 |
N-oxidation of imipramine by isolated perfused rat and rabbit lung.
Topics: Animals; Cytosol; Desipramine; Imipramine; Lung; Male; Microsomes; Mitochondria; Oxidation-Reduction; Perfusion; Proadifen; Rabbits; Rats; Species Specificity; Subcellular Fractions | 1980 |
Quantitative analysis for tricyclic antidepressant drugs in plasma or serum by gas chromatography-chemical-ionization mass spectrometry.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Desipramine; Female; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Male; Middle Aged; Nortriptyline | 1980 |
An external quality-control scheme for tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Desipramine; Humans; Imipramine; Laboratories; Nortriptyline; Quality Control; United Kingdom | 1980 |
The effects of tricyclic antidepressants on performance under a differential-reinforcement-of-low-rates schedule in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Conditioning, Operant; Desipramine; Dose-Response Relationship, Drug; Imipramine; Male; Rats; Reinforcement Schedule; Scopolamine | 1980 |
Unsuspected impurities in imipramine and desipramine standards and pharmaceutical formulations.
Topics: Chemistry, Pharmaceutical; Desipramine; Gas Chromatography-Mass Spectrometry; Imipramine; Reference Standards | 1981 |
Inhibition of neuronal nicotinic acetylcholine receptors by imipramine and desipramine.
Topics: Desipramine; Dimethylphenylpiperazinium Iodide; Electrophysiology; Humans; Imipramine; Ion Channels; Membrane Potentials; Nervous System Neoplasms; Neuroblastoma; Neurons; Nicotinic Antagonists; Tumor Cells, Cultured | 1993 |
[Ca(2+)-channel blockers and binding of tricyclic antidepressive agents].
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Platelets; Calcium Channel Blockers; Cattle; Cell Membrane; Desipramine; Gallopamil; Humans; Imipramine; In Vitro Techniques; Lymphocytes; Phosphatidylserines; Synaptic Membranes; Verapamil | 1995 |
Rapid microsample analysis of imipramine and desipramine by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Antidepressive Agents, Tricyclic; Artifacts; Chromatography, High Pressure Liquid; Desipramine; Female; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Orosomucoid; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1995 |
Chronic antidepressant treatment down-regulates the induction of c-fos mRNA in response to acute stress in rat frontal cortex.
Topics: 1-Naphthylamine; Amino Acid Isomerases; Animals; Antidepressive Agents; Carrier Proteins; Desipramine; Down-Regulation; Frontal Lobe; Imipramine; Male; Peptidylprolyl Isomerase; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Restraint, Physical; RNA, Messenger; Sertraline; Stress, Psychological; Time Factors; Tranylcypromine | 1995 |
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.
Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Denmark; Desipramine; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Sparteine | 1995 |
Electrophysiological effects of the combination of imipramine and desipramine in guinea pig papillary muscles.
Topics: Action Potentials; Animals; Desipramine; Drug Interactions; Electrophysiology; Female; Guinea Pigs; Imipramine; In Vitro Techniques; Male; Membrane Potentials; Papillary Muscles | 1993 |
Triiodothyronine increases desipramine with changing the concentrations of monoamines, in the brain of rat given imipramine.
Topics: Animals; Biogenic Monoamines; Biotransformation; Brain; Desipramine; Half-Life; Hydroxyindoleacetic Acid; Imipramine; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Wistar; Serotonin; Triiodothyronine | 1993 |
Effects of benzylpiperazine derivatives on the acute effects of 3,4-methylenedioxymethamphetamine in rat brain.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Desipramine; Hydroxyindoleacetic Acid; Imipramine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptosomes | 1993 |
Inhibition by antidepressants of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antihypertensive Agents; Benzopyrans; Desipramine; Female; Glyburide; Imipramine; In Vitro Techniques; Oocytes; Potassium Channel Blockers; Potassium Channels; Xenopus laevis | 1994 |
Design of a desipramine dosing regimen for the rapid induction and maintenance of maximal cortical beta-adrenoceptor downregulation.
Topics: Animals; Brain; Cerebral Cortex; Desipramine; Down-Regulation; Imipramine; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1994 |
Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk.
Topics: Adolescent; Adult; Anemia; Carbamazepine; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Hospitalization; Humans; Imipramine; Leukopenia; Male; Middle Aged; Pharmacoepidemiology; Prevalence; Severity of Illness Index; Thrombocytopenia; Valproic Acid | 1995 |
Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine.
Topics: Adult; Biomarkers; Blood Platelets; Cell Membrane; Citalopram; Depressive Disorder; Desipramine; Female; Humans; Imipramine; In Vitro Techniques; Male; Middle Aged; Paroxetine; Receptors, Serotonin; Sodium | 1993 |
Immunoassay reagents for psychoactive drugs. Part 5. Quantitative determination of imipramine and desipramine by fluorescence polarization immunoassay.
Topics: Chromatography, High Pressure Liquid; Desipramine; Drug Interactions; Fluorescence Polarization Immunoassay; Humans; Imipramine; Psychotropic Drugs | 1994 |
REM sleep deprivation potentiates the effects of imipramine and desipramine but not that of clomipramine in the forced swimming test.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Brain; Clomipramine; Desipramine; Imipramine; Male; Mice; Receptors, Adrenergic, alpha; Sleep Deprivation; Sleep, REM; Swimming; Yohimbine | 1993 |
The pharmacodynamics of desipramine and desmethyldesipramine in rats.
Topics: Adrenergic beta-Antagonists; Animals; Binding Sites; Desipramine; Dose-Response Relationship, Drug; Down-Regulation; Imipramine; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1994 |
Severe imipramine-induced myoclonus in a patient with psychotic bipolar depression, catatonia, and schizencephaly.
Topics: Adult; Bipolar Disorder; Catatonia; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Imipramine; Lithium Carbonate; Myoclonus; Neurocognitive Disorders; Parietal Lobe | 1994 |
Decreased plasma concentrations of imipramine and desipramine following cholestyramine intake in depressed patients.
Topics: Adult; Cholestyramine Resin; Depression; Desipramine; Drug Interactions; Female; Humans; Imipramine; Male; Middle Aged | 1994 |
Platelet 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age.
Topics: Adult; Age Factors; Binding Sites; Blood Platelets; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Infant; Male; Paroxetine; Serotonin | 1994 |
Behavioral and neurochemical mechanisms of opioid-antidepressant interactions.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Columbidae; Conditioning, Operant; Desipramine; Dose-Response Relationship, Drug; Endorphins; Female; Imipramine; Methadone; Norepinephrine; Reinforcement Schedule | 1994 |
Surface ionization organic mass spectrometry of imipramine, desipramine, clomipramine, and lidocaine.
Topics: Clomipramine; Desipramine; Humans; Imipramine; Lidocaine; Mass Spectrometry; Sensitivity and Specificity; Surface Properties | 1994 |
Measurement and pharmacokinetic analysis of imipramine and its metabolite by brain microdialysis.
Topics: Aminopyrine; Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Half-Life; Imipramine; Male; Microdialysis; Proadifen; Rats; Rats, Wistar | 1994 |
Augmentation strategies with tricyclic or fluoxetine treatment in seven partially responsive panic disorder patients.
Topics: Adult; Alprazolam; Antidepressive Agents, Tricyclic; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Imipramine; Lorazepam; Male; Panic Disorder; Retrospective Studies; Treatment Outcome | 1994 |
The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Desipramine; Humans; Hydroxylation; Imipramine; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases | 1994 |
Fluvoxamine-induced alterations in plasma concentrations of imipramine and desipramine in depressed patients.
Topics: Adult; Depressive Disorder; Desipramine; Drug Interactions; Female; Fluvoxamine; Humans; Imipramine; Male; Middle Aged | 1993 |
Concurrent liquid chromatographic measurement of fluoxetine, amitriptyline, imipramine, and their active metabolites norfluoxetine, nortriptyline, and desipramine in plasma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Fluoxetine; Humans; Imipramine; Indicators and Reagents; Nortriptyline; Spectrophotometry, Ultraviolet | 1993 |
Regional differences in the levels of biogenic amines and their metabolites in rat brain after tricyclic antidepressant treatments.
Topics: Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Brain; Desipramine; Imipramine; Male; Rats; Rats, Sprague-Dawley | 1993 |
The study of tricyclic antidepressants in formalin-fixed human liver and formalin solutions.
Topics: Amitriptyline; Cryopreservation; Desipramine; Drug Overdose; Drug Stability; Embalming; Evaluation Studies as Topic; Forensic Medicine; Formaldehyde; Humans; Imipramine; Liver; Methylation; Nortriptyline; Poisoning; Temperature; Time Factors | 1993 |
Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line.
Topics: Catalysis; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Humans; Imipramine; Isoenzymes; Methylation; Mixed Function Oxygenases; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity | 1993 |
Interactions between sertraline and tricyclic antidepressants.
Topics: 1-Naphthylamine; Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Interactions; Humans; Imipramine; Male; Selective Serotonin Reuptake Inhibitors; Sertraline | 1993 |
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti
Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electrochemistry; Glucuronidase; Humans; Hydroxylation; Imipramine; Male; Oxidation-Reduction; Phenotype; Psychotropic Drugs; Sensitivity and Specificity; Sparteine; Time Factors; Tranquilizing Agents | 1993 |
Effect of fluvoxamine on the pharmacokinetics of imipramine and desipramine in healthy subjects.
Topics: Adult; Desipramine; Drug Interactions; Fluvoxamine; Humans; Imipramine; Male | 1993 |
Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability.
Topics: Acetylation; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Isoenzymes; Mixed Function Oxygenases | 1993 |
Immunoassay reagents for psychoactive drugs. II. The method for the development of antibodies specific to imipramine and desipramine.
Topics: Animals; Antibody Formation; Antibody Specificity; Antidepressive Agents, Tricyclic; Cross Reactions; Desipramine; Dose-Response Relationship, Immunologic; Fluorescence Polarization Immunoassay; Imipramine; Immune Sera; Rabbits; Sensitivity and Specificity; Vaccines, Synthetic | 1993 |
p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Desipramine; Fenclonine; Fluoxetine; Guanidines; Hippocampus; Imipramine; Kinetics; Male; Proteins; Rats; Rats, Wistar; Receptors, sigma; Serotonin | 1993 |
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin | 1993 |
Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ store by antidepressant drugs in cultured neurons of rat frontal cortex.
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Calcium; Cells, Cultured; Desipramine; Dose-Response Relationship, Drug; Embryo, Mammalian; Frontal Lobe; Imipramine; Inositol 1,4,5-Trisphosphate; Kinetics; Mianserin; Neomycin; Neurons; Rats; Rats, Wistar | 1993 |
Effects of antidepressant drug treatment on levels of NPY or prepro-NPY-mRNA in the rat brain.
Topics: Animals; Antidepressive Agents, Tricyclic; Blotting, Northern; Brain; Clomipramine; Desipramine; Frontal Lobe; Hippocampus; Imipramine; Male; Neuropeptide Y; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine.
Topics: Arylsulfatases; Chromatography, High Pressure Liquid; Desipramine; Glucuronidase; Humans; Imipramine; Reference Standards | 1993 |
The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study.
Topics: Adolescent; Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic; Sparteine | 1993 |
Juvenile desipramine reduces adult sensitivity to imipramine in two behavioral tests.
Topics: Animals; Behavior, Animal; Defecation; Depression; Desipramine; Female; Imipramine; Motor Activity; Rats; Swimming | 1993 |
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
Topics: 1-Naphthylamine; Animals; Antidepressive Agents; Base Sequence; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Desipramine; Electric Stimulation; Fluoxetine; Hippocampus; Imipramine; In Situ Hybridization; Male; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Nerve Growth Factor; RNA, Messenger; Rolipram; Sertraline; Time Factors; Tranylcypromine | 1996 |
High-performance liquid chromatographic method for the analysis of imipramine metabolism in vitro by liver and brain microsomes.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Hydroxylation; Imipramine; Male; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1995 |
Characteristics of the inhibitory effect of tricyclic antidepressants on histamine release from rat peritoneal mast cells.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Buffers; Calcium; Clomipramine; Desipramine; Histamine Release; Imipramine; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Structure-Activity Relationship | 1996 |
ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine.
Topics: Adolescent; Alberta; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivity; Child; Death, Sudden, Cardiac; Depressive Disorder; Desipramine; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Imipramine; Long QT Syndrome; Male; Risk Factors | 1996 |
Spectroscopic analysis of charge transfer complex formation and peroxidase inhibition with tricyclic antidepressant drugs: potential anti-thyroid action.
Topics: Antidepressive Agents, Tricyclic; Antithyroid Agents; Clomipramine; Desipramine; Horseradish Peroxidase; Imipramine; Iodine; Kinetics; Methimazole; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1996 |
Fluoxetine-imipramine interaction.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluoxetine; Humans; Imipramine; Lithium; Suicide Prevention | 1996 |
In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cerebral Cortex; Citalopram; Clonidine; Desipramine; Fluoxetine; Fluvoxamine; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1996 |
Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Desipramine; Fluoxetine; Imipramine; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Selective Serotonin Reuptake Inhibitors; Stereoisomerism | 1996 |
Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Japan; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Pharmacogenetics; Phenotype | 1996 |
Study addresses question of preferred initial therapy for depression.
Topics: Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Depression; Desipramine; Drug Costs; Fluoxetine; Humans; Imipramine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors | 1996 |
SSRI or tricyclics for depression?
Topics: Adult; Depression; Depressive Disorder; Desipramine; Family Practice; Fluoxetine; Humans; Imipramine; Randomized Controlled Trials as Topic; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1996 |
Steady-state kinetics of imipramine in transgenic mice with elevated serum AAG levels.
Topics: Animals; Antidepressive Agents; Biological Transport; Blood Proteins; Brain; Desipramine; Female; Imipramine; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Orosomucoid; Protein Binding | 1996 |
Imipramine distribution among red blood cells, plasma and brain tissue.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cytosol; Desipramine; Erythrocyte Membrane; Erythrocytes; Imipramine; Membranes; Radioimmunoassay; Rats; Rats, Wistar; Tissue Distribution; Tritium | 1996 |
Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine N-demethylation.
Topics: Animals; Base Sequence; Blotting, Southern; Brain; Chromatography, High Pressure Liquid; COS Cells; Cytochrome P-450 Enzyme System; Desipramine; DNA, Complementary; Imipramine; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Rats; Single-Strand Specific DNA and RNA Endonucleases | 1996 |
Paroxetine shifts imipramine metabolism.
Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 Enzyme System; Depressive Disorder; Desipramine; Drug Synergism; Humans; Imipramine; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors | 1996 |
Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.
Topics: Amoxapine; Amygdala; Animals; Antidepressive Agents; Clomipramine; Corpus Striatum; Desipramine; Imipramine; Male; Mianserin; Radioimmunoassay; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Substance P; Substantia Nigra; Time Factors | 1996 |
The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Benzopyrans; Cromakalim; Desipramine; Drug Interactions; Imipramine; Locomotion; Male; Mianserin; Mice; Minoxidil; Paroxetine; Physical Exertion; Potassium Channels; Pyrroles; Swimming | 1996 |
Potential antidepressant effects of lemon odor in rats.
Topics: Animals; Antidepressive Agents; Citrus; Depression; Desipramine; Imipramine; Male; Motor Activity; Odorants; Rats; Rats, Sprague-Dawley | 1995 |
Case study: two additional sudden deaths with tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Child; Death, Sudden; Desipramine; Humans; Imipramine; Male; Thioridazine | 1997 |
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
Topics: Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Desipramine; Drug Interactions; Fluoxetine; Fluvoxamine; Imipramine; Ketanserin; Male; Maprotiline; Mice; Ondansetron; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 1997 |
Sensitive microanalysis of imipramine and desipramine in single rat thyroids by gas chromatography-mass spectrometry.
Topics: Animals; Antidepressive Agents, Tricyclic; Desipramine; Gas Chromatography-Mass Spectrometry; Imipramine; Male; Rats; Rats, Wistar; Reproducibility of Results; Thyroid Gland | 1997 |
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Sensitivity and Specificity | 1997 |
[A study of the effects of antidepressants on the GABAA receptor and its complex based on the drug actions on the power-spectral changes of rat hippocampal EEG induced by GABA antagonists and inverse agonists].
Topics: Animals; Antidepressive Agents; Carbolines; Depression, Chemical; Desipramine; Electroencephalography; Fluoxetine; GABA Antagonists; Hippocampus; Imipramine; Male; Norepinephrine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Trazodone | 1997 |
Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2.
Topics: 1-Naphthylamine; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cyclohexanols; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Fluoxetine; Fluvoxamine; Frozen Sections; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Lethal Dose 50; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Venlafaxine Hydrochloride | 1997 |
A computer model and program for xenobiotic disposition during pregnancy.
Topics: Animals; Computer Simulation; Desipramine; Female; Humans; Imipramine; Maternal-Fetal Exchange; Mercury; Methylmercury Compounds; Models, Biological; Pregnancy; Rats; Software; Xenobiotics | 1997 |
Acute lung failure induced by tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Imipramine; Lung; Maprotiline; Mianserin; Microscopy, Electron; Nortriptyline; Organ Size; Perfusion; Pulmonary Edema; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley | 1997 |
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle.
Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley | 1997 |
Interaction mechanisms of imipramine and desipramine with enkephalin-degrading aminopeptidases in vitro.
Topics: Aminopeptidases; Animals; Antidepressive Agents, Tricyclic; Desipramine; Drug Interactions; Enkephalins; Hydrolysis; Imipramine; Kinetics; Male; Rats; Rats, Sprague-Dawley | 1997 |
Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Cattle; Cells, Cultured; Chromaffin Cells; Desipramine; Imipramine; Membrane Potentials; Nicotine; Nicotinic Antagonists; Potassium; Receptors, Nicotinic | 1997 |
Influence of imipramine on the hypothalamic/pituitary/thyroid axis of the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain Chemistry; Cells, Cultured; Desipramine; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Imipramine; Injections, Intraperitoneal; Liver; Male; Myocardium; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1997 |
Simultaneous determination of imipramine and its metabolite desipramine in human plasma by capillary gas chromatography with mass-selective detection.
Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Circadian Rhythm; Desipramine; Drug Stability; Humans; Imipramine; Osmolar Concentration; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 1997 |
Individual differences in response to imipramine in the mouse tail suspension test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Imipramine; Individuality; Male; Mice; Mice, Inbred Strains; Motor Activity; Paroxetine; Restraint, Physical | 1997 |
[3H] imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Binding Sites; Brain; Cause of Death; Depressive Disorder; Desipramine; Female; Frontal Lobe; Humans; Imipramine; Male; Middle Aged; Putamen; Radioligand Assay; Serotonin; Substantia Nigra; Suicide; Tritium | 1998 |
Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Desipramine; Electric Stimulation; Electromyography; Enzyme Inhibitors; Imipramine; Jaw; Locomotion; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Nortriptyline; Rats; Rats, Sprague-Dawley; Reflex | 1998 |
The 5-HT3 receptor agonist attenuates the action of antidepressants in the forced swim test in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biguanides; Desipramine; Imipramine; Indoles; Male; Mianserin; Motor Activity; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Tropisetron; Volition | 1998 |
Distinct effects of imipramine on 5-hydroxytryptamine uptake mediated by the recombinant rat serotonin transporter SERT1.
Topics: Allosteric Site; Animals; Antidepressive Agents, Tricyclic; Biological Transport; Carrier Proteins; Cell Line; Citalopram; Clomipramine; Desipramine; Humans; Imipramine; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sodium | 1998 |
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Drug Monitoring; Humans; Imipramine; Linear Models; Nortriptyline; Promazine; Sensitivity and Specificity | 1998 |
Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Brain Stem; Carrier Proteins; Clomipramine; Cloning, Molecular; Desipramine; DNA, Complementary; Fluoxetine; Guinea Pigs; HeLa Cells; Humans; Imipramine; Intestinal Mucosa; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peristalsis; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transcription, Genetic; Zimeldine | 1998 |
Prevalence variations in psychotropic treatment of children.
Topics: Adult; Antidepressive Agents, Tricyclic; Child; Desipramine; Dopamine Uptake Inhibitors; Drug Utilization; Female; Humans; Imipramine; Male; Medicaid; Methylphenidate; Middle Aged; Psychotropic Drugs; United States | 1998 |
Thyroid accumulation and adverse effects of imipramine and desipramine in rats after long-term administration.
Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Desipramine; Imipramine; Male; Rats; Rats, Wistar; Thyroid Gland; Thyroid Hormones | 1998 |
Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Hypoxia; Imipramine; Inositol 1,4,5-Trisphosphate; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Norepinephrine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ventricular Fibrillation | 1998 |
Distribution of paroxetine in three postmortem cases.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Drug Interactions; Drug Overdose; Fatal Outcome; Female; Humans; Imipramine; Male; Middle Aged; Paroxetine; Suicide; Tissue Distribution | 1998 |
In vitro effect of central nervous system active drugs on the ATPase-ADPase activity and acetylcholinesterase activity from cerebral cortex of adult rats.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Amitriptyline; Animals; Apyrase; Central Nervous System Agents; Cerebral Cortex; Desipramine; Diazepam; Hydrolases; Imipramine; In Vitro Techniques; Lithium; Rats; Synaptosomes | 1998 |
Isolation of partially purified P450 2D18 and characterization of activity toward the tricyclic antidepressants imipramine and desipramine.
Topics: Aryl Hydrocarbon Hydroxylases; Baculoviridae; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Enzyme Activation; Enzyme Inhibitors; Humans; Imipramine; Isoenzymes; Ketoconazole; Piperazines; Recombinant Proteins | 1998 |
Stability of tricyclic antidepressants in formalin solutions.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Drug Stability; Forensic Medicine; Formaldehyde; Imipramine; Nortriptyline; Substance Abuse Detection; Time Factors | 1998 |
The effect of chronic administration of antidepressants on the circadian pattern of corticosterone in the rat.
Topics: Animals; Antidepressive Agents; Circadian Rhythm; Clomipramine; Corticosterone; Desipramine; Hypothalamo-Hypophyseal System; Imipramine; Male; Phenelzine; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley | 1998 |
Inhibition of imipramine N-demethylation by fluvoxamine in Chinese young men.
Topics: Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Desipramine; Drug Interactions; Fluvoxamine; Humans; Imipramine; Male; Selective Serotonin Reuptake Inhibitors | 1996 |
Enhancement of serotonin 2C receptor mRNA expression by antidepressants possessing the receptor-blocking activity in the rat brain.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Dopamine Uptake Inhibitors; Gene Expression Regulation; Imipramine; In Situ Hybridization; Male; Mianserin; Nomifensine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists | 1998 |
Effect of psychotropic drugs on taste responses in young and elderly persons.
Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; Male; Psychotropic Drugs; Taste; Trifluoperazine | 1998 |
Nonaqueous capillary electrophoretic separation and thermo-optical absorbance detection of five tricyclic antidepressants and metabolism of amitriptyline by Cunninghamella elegans.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Cunninghamella; Desipramine; Electrophoresis, Capillary; Imipramine; Molecular Structure; Nortriptyline | 1998 |
On-line nonaqueous capillary electrophoresis and electrospray mass spectrometry of tricyclic antidepressants and metabolic profiling of amitriptyline by Cunninghamella elegans.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Calibration; Clomipramine; Cunninghamella; Desipramine; Electrophoresis, Capillary; Imipramine; Mass Spectrometry; Molecular Structure | 1998 |
Non-aqueous capillary electrophoresis of drugs: properties and application of selected solvents.
Topics: 4-Aminobenzoic Acid; Acetonitriles; Aminobenzoates; Carbonates; Desipramine; Dimethyl Sulfoxide; Dimethylformamide; Electrophoresis, Capillary; Formamides; Hydrogen-Ion Concentration; Ibuprofen; Imipramine; Methanol; Models, Statistical; Organic Chemicals; ortho-Aminobenzoates; Propane; Solvents; Temperature; Time Factors; Viscosity; Water | 1999 |
An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug; Imipramine; Lofepramine; Male; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Swimming | 1999 |
Molecular cloning, expression and characterization of a bovine serotonin transporter.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection | 1999 |
Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Coculture Techniques; Desipramine; Electric Impedance; Endothelium, Vascular; Fluorescent Antibody Technique, Indirect; Formazans; Humans; Imipramine; Muscle, Smooth, Vascular; Nortriptyline; Spectrometry, Fluorescence; Tetrazolium Salts; Tight Junctions; Umbilical Cord | 1999 |
Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dibenzocycloheptenes; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Escape Reaction; Haloperidol; Helplessness, Learned; Imipramine; Male; Motor Activity; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar | 1999 |
Spectrophotometry assay of imipramine and desipramine using ammonium metavanadate and its application to pharmaceutical preparations.
Topics: Antidepressive Agents, Tricyclic; Desipramine; Imipramine; Indicators and Reagents; Iodates; Iron; Oxidants; Pharmaceutical Solutions; Potassium Dichromate; Spectrophotometry, Ultraviolet; Tablets; Temperature; Vanadates | 2000 |
The analysis of basic and acidic compounds using non-aqueous CE and non-aqueous CE-MS.
Topics: Antidepressive Agents, Tricyclic; Catecholamines; Desipramine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Imipramine; Mass Spectrometry; Pharmaceutical Preparations | 2000 |
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments.
Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Dopamine; Dynorphins; Electroshock; Fluoxetine; Gene Expression; Imipramine; Islands of Calleja; Limbic System; Male; Monoamine Oxidase Inhibitors; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Substance P; Tranylcypromine | 2000 |
TCAs or SSRIs as initial therapy for depression?
Topics: Adult; Antidepressive Agents, Tricyclic; Costs and Cost Analysis; Depression; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Imipramine; Male; Randomized Controlled Trials as Topic; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 1999 |
Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain Chemistry; Desipramine; Fluoxetine; Imipramine; Male; Mesencephalon; Neurosecretory Systems; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, beta; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Species Specificity | 2000 |
Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes.
Topics: Animals; Antidepressive Agents; Desipramine; Electroencephalography; Fluoxetine; Fourier Analysis; GABA Antagonists; Hippocampus; Imipramine; Male; Nortriptyline; Pentylenetetrazole; Rats; Rats, Wistar; Trazodone | 2000 |
Therapeutic effects of imipramine are counteracted by its metabolite, desipramine, in patients with generalized anxiety disorder.
Topics: Adrenergic Uptake Inhibitors; Adult; Anxiety Disorders; Arrhythmia, Sinus; Blood Pressure; Desipramine; Drug Interactions; Female; Heart Rate; Humans; Imipramine; Linear Models; Male; Middle Aged; Psychiatric Status Rating Scales | 2000 |
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.
Topics: Animals; Antidepressive Agents; Brain; Cell Division; Cells, Cultured; Cerebellum; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Nervous System; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Thymidine | 2001 |
Localization and characterization of a short isoform of the corticotropin-releasing factor receptor type 2alpha (CRF(2)alpha-tr) in the rat brain.
Topics: Amino Acid Sequence; Amygdala; Animals; Antidepressive Agents, Tricyclic; Base Sequence; Binding Sites; Brain; Corticotropin-Releasing Hormone; Desipramine; Humans; Imipramine; In Situ Hybridization; Molecular Sequence Data; Protein Isoforms; Rats; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Sequence Deletion | 2001 |
New reagents for detection of faecal occult blood.
Topics: Alkanes; Desipramine; Edetic Acid; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Metals; Occult Blood; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Chip-based quantitative capillary electrophoresis/mass spectrometry determination of drugs in human plasma.
Topics: Acetylcarnitine; Carnitine; Desipramine; Electrophoresis, Capillary; Feasibility Studies; Humans; Imipramine; Mass Spectrometry; Molecular Structure | 2001 |
Structural analysis of chloroquine resistance reversal by imipramine analogs.
Topics: Animals; Antimalarials; Chloroquine; Desipramine; Drug Interactions; Drug Resistance; Humans; Imipramine; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum | 2001 |
St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Astrocytoma; Cerebral Cortex; Desipramine; Hypericum; Imipramine; Norepinephrine; Organ Culture Techniques; Plant Extracts; Rats; Receptors, Adrenergic, beta; Serotonin; Tumor Cells, Cultured | 2001 |
Effects of Hypericum perforatum (St. John's wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Desipramine; Hypericum; Imipramine; Male; Muscarinic Antagonists; Norepinephrine; Paroxetine; Plant Extracts; Rats; Rats, Sprague-Dawley; Scopolamine; Serotonin | 2001 |
Effect of ACTH on the imipramine- and desipramine-induced decrease in duration of immobility time as measured in a rat forced swimming test.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Exercise Test; Imipramine; Immobilization; Male; Motor Activity; Rats; Rats, Wistar; Swimming; Time Factors | 2001 |
Sample preparation with fiber-in-tube solid-phase microextraction for capillary electrophoretic separation of tricyclic antidepressant drugs in human urine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Imipramine; Nortriptyline; Specimen Handling | 2001 |
Antidepressants do not modulate estrogen receptor alpha-mediated gene expression.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cell Line; Desipramine; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Gene Expression Regulation; Genes, Reporter; Haplorhini; Humans; Imipramine; Rats; Receptors, Estrogen; Tumor Cells, Cultured | 2001 |
Clomipramine and related structures as inhibitors of the skeletal sarcoplasmic reticulum Ca2+ pump.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Calcium; Calcium-Transporting ATPases; Clomipramine; Desipramine; Enzyme Inhibitors; Imipramine; Magnesium; Muscle, Skeletal; Phosphorylation; Rabbits; Sarcoplasmic Reticulum; Trimipramine | 2000 |
Falsely elevated imipramine levels in a patient taking quetiapine.
Topics: Child; Child Behavior Disorders; Chromatography, High Pressure Liquid; Desipramine; Dibenzothiazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; False Positive Reactions; Humans; Imipramine; Male; Quetiapine Fumarate | 2002 |
Imipramine hydrochloride and desipramine hydrochloride as new reagents for detection of microamounts of blood in urine.
Topics: Acetates; Benzidines; Desipramine; Diet; Hematuria; Humans; Hydrogen Peroxide; Imipramine; Indicators and Reagents; Reproducibility of Results | 2002 |
Sister chromatid exchanges produced by imipramine and desipramine in mouse bone marrow cells treated in vivo.
Topics: Animals; Antidepressive Agents, Tricyclic; Bone Marrow; Cyclophosphamide; Desipramine; Imipramine; Injections, Intraperitoneal; Male; Mice; Mutagens; Regression Analysis; Sister Chromatid Exchange | 2002 |
Inhibition of SK3 channels in the TE671 human medulloblastoma cell line by desipramine and imipramine.
Topics: Desipramine; Dose-Response Relationship, Drug; Humans; Imipramine; Medulloblastoma; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Small-Conductance Calcium-Activated Potassium Channels; Tumor Cells, Cultured | 2002 |
An electrospray ionization source for integration with microfluidics.
Topics: Cytochrome c Group; Desipramine; Imipramine; Nanotechnology; Spectrometry, Mass, Electrospray Ionization | 2002 |
Cortical alpha-adrenoceptor downregulation by tricyclic antidepressants in the rat brain.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Cerebral Cortex; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Down-Regulation; Hippocampus; Imipramine; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Time Factors | 2003 |
Antidepressant-like effects in various mice strains in the tail suspension test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Citalopram; Depression; Desipramine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hindlimb Suspension; Imipramine; Male; Mice; Mice, Inbred Strains; Paroxetine; Selective Serotonin Reuptake Inhibitors; Species Specificity | 2003 |
Clinical trial with desmethylimipramine (G-35020), a new antidepressive compound.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Imipramine | 1962 |
Preliminary pharmacological and clinical results with desmethylimipramine (DMI) G 35020, a metabolite of imipramine.
Topics: Desipramine; Humans; Imipramine | 1961 |
Desmethylimipramine, a new type of antidepressant drug.
Topics: Antidepressive Agents; Desipramine; Humans; Imipramine | 1961 |
Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil).
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Imipramine; Neurochemistry; Rats | 1961 |
The effect of imipramine and desmethylimipramine on lipid bio-synthesis in brain and liver.
Topics: Antidepressive Agents; Brain; Desipramine; Imipramine; Lipid Metabolism; Lipids; Liver | 1963 |
Aspects of the clinical chemistry of desmethylimipramine in man.
Topics: Chemistry, Clinical; Desipramine; Imipramine | 1963 |
THE USE OF "PERTOFRAN" IN DEPRESSION: A SHORT COMMUNICATION.
Topics: Communication; Depression; Depressive Disorder; Desipramine; Humans; Imipramine | 1963 |
COMPARISON BETWEEN IMIPRAMINE AND DESIPRAMINE IN NORMAL SUBJECTS AND THEIR ACTION IN DEPRESSIVE PATIENTS.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine | 1963 |
COMBINED ADMINISTRATION OF DESIPRAMINE AND RESERPINE OR TETRABENAZINE IN DEPRESSIVE PATIENTS.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Reserpine; Tetrabenazine | 1963 |
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE, A METABOLITE OF IMIPRAMINE.
Topics: Adolescent; Antidepressive Agents; Brain Diseases; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Geriatrics; Humans; Imipramine; Mental Disorders; Neurotic Disorders; Psychotic Disorders | 1963 |
INFLUENCE OF IMIPRAMINE AND RELATED PSYCHOACTIVE AGENTS ON THE EFFECT OF 5-HYDROXYTRYPTAMINE AND CATECHOLAMINES ON THE CAT NICTITATING MEMBRANE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Catecholamines; Cats; Chlorpromazine; Chlorprothixene; Desipramine; Epinephrine; Imipramine; Nictitating Membrane; Norepinephrine; Pharmacology; Promazine; Psychotropic Drugs; Research; Serotonin; Tranquilizing Agents | 1963 |
[ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)].
Topics: Aging; Antidepressive Agents; Bipolar Disorder; Body Constitution; Desipramine; Humans; Imipramine; Mental Disorders; Psychotic Disorders; Research | 1963 |
[DRUGS ACTING ON THE NERVOUS SYSTEM. (2). WITH SPECIAL REFERENCE TO TRANQUILIZERS AND ANTIDEPRESSIVE AGENTS].
Topics: Amides; Amitriptyline; Antidepressive Agents; Benactyzine; Chemical Phenomena; Chemistry; Chlordiazepoxide; Desipramine; Diazepam; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Imipramine; Isocarboxazid; Meprobamate; Methylphenidate; Monoamine Oxidase Inhibitors; Nervous System; Nialamide; Pharmacology; Phenelzine; Piperidines; Tranquilizing Agents; Tranylcypromine; Tryptamines | 1963 |
[RESULTS OF THE USE OF DESMETHYL-IMIPRAMINE (G-35020, PERTOFRAN) IN THE DEPRESSIVE SYNDROME].
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Imipramine; Mental Disorders; Psychotic Disorders | 1963 |
SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).
Topics: Animals; Antidepressive Agents; Biomedical Research; Desipramine; Imipramine; Metabolism; Mice; Rabbits; Rats; Research; Species Specificity | 1964 |
[DESMETHYLIMIPRAMINE (PERTOFRAN) IN THE TREATMENT OF DEPRESSIONS. A CLINICAL AND PSYCHODYNAMIC APPRAISAL].
Topics: Antidepressive Agents; Biomedical Research; Bipolar Disorder; Chlorpromazine; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Humans; Imipramine; Psychotic Disorders; Schizophrenia | 1963 |
[PRELIMINARY OBSERVATIONS ON THE CLINICAL USE OF A METABOLITE OF IMIPRAMINE: DESMETHYLIMIPRAMINE (G 35020)].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Mental Disorders; Neurotic Disorders; Obsessive-Compulsive Disorder | 1963 |
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Chlorides; Desipramine; Electrocardiography; Guanethidine; Imipramine; Pharmacology; Quinidine; Rats; Research; Reserpine; Tachycardia; Ventricular Fibrillation | 1964 |
[LONG-TERM DRUG TREATMENT OF CRIMINALS. PRELIMINARY EXPERIENCES].
Topics: Antidepressive Agents; Chlordiazepoxide; Criminals; Criminology; Denmark; Desipramine; Humans; Imipramine; Mental Disorders; Opipramol; Perphenazine | 1964 |
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine | 1964 |
PSYCHOPHARMACOLOGY OF IMIPRAMINE AND DESIPRAMINE: A COMPARATIVE STUDY OF THEIR EFFECTS IN NORMAL MALES.
Topics: Antidepressive Agents; Anxiety; Biomedical Research; Blood Pressure Determination; Cognition; Desipramine; Imipramine; Motor Skills; Placebos; Psychological Tests; Psychopharmacology; Toxicology | 1964 |
INFLUENCE OF DESMETHYLIMIPRAMINE ON THE PRESSOR RESPONSES TO ANGIOTENSIN.
Topics: Angiotensins; Blood Pressure; Blood Pressure Determination; Desipramine; Dogs; Imipramine; Pharmacology; Research; Reserpine; Vasoconstrictor Agents | 1964 |
[DESIPRAMINE (PERTOFRAN) IN THE TREATMENT OF DEPRESSIONS WITH A PSYCHODYNAMIC ANALYSIS OF ITS THERAPEUTIC EFFECTS].
Topics: Antidepressive Agents; Biomedical Research; Bipolar Disorder; Depression; Depressive Disorder; Desipramine; Imipramine; Pharmacology; Psychoanalysis; Psychotic Disorders; Toxicology | 1964 |
THE EFFECT OF DESMETHYLIMIPRAMINE ON RESERPINE AND INSULIN-INDUCED RELEASE OF GASTRIC HISTAMINE AND ADRENAL CATECHOLAMINES.
Topics: Adrenal Glands; Catecholamines; Desipramine; Gastric Juice; Histamine; Histamine Release; Imipramine; Insulin; Pharmacology; Rats; Research; Reserpine; Stomach | 1964 |
[ACTION OF DESMETHYL-IMIPRAMINE (PERTOFRAN) IN DEPRESSIVE SYNDROMES].
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Imipramine; Neurotic Disorders; Obsessive-Compulsive Disorder; Psychotic Disorders | 1964 |
[COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS WITH TOFRANIL, PERTOFRAN AND INSIDON].
Topics: Acetylcholine; Amphetamine; Amphetamines; Anesthetics; Animals; Antidepressive Agents; Catatonia; Cats; Chlorpromazine; Cricetinae; Desipramine; Dextroamphetamine; Epinephrine; Ethanol; Guinea Pigs; Hexobarbital; Histamine; Imipramine; Mice; Neuromuscular Junction; Norepinephrine; Opipramol; Orientation; Pharmacology; Rats; Research; Reserpine; Serotonin; Tetrabenazine; Tremor; Tyramine | 1964 |
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS.
Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dogs; Dopamine; Electric Stimulation; Electrophysiology; Guanethidine; Imipramine; Metaraminol; Methylphenidate; Mice; Myocardium; Nictitating Membrane; Norepinephrine; Pharmacology; Piperidines; Promazine; Research; Reserpine; Tripelennamine; Tyrosine | 1964 |
EFFECT OF CENTRALLY-ACTING DRUGS ON MOBILIZATION OF FREE FATTY ACIDS.
Topics: Central Nervous System Agents; Chlorpromazine; Desipramine; Fatty Acids; Fatty Acids, Nonesterified; Hallucinogens; Imipramine; Indoles; Lipid Metabolism; Lipids; Lysergic Acid Diethylamide; Mescaline; Pharmacology; Psilocybin; Reserpine; Thioridazine; Tranquilizing Agents | 1964 |
IMIPRAMINE-DESMETHYLIMIPRAMINE. A PHARMACOLOGICAL STUDY ON HUMAN BEINGS.
Topics: Blood Pressure; Blood Pressure Determination; Desipramine; Fatigue; Heart Rate; Humans; Imipramine; Motor Skills; Placebos; Psychological Tests; Pulse; Reaction Time | 1964 |
ACUTE AND CHRONIC EFFECTS OF IMIPRAMINE AND DESIPRAMINE IN NORMAL RATS AND IN RATS WITH LESIONED AMYGDALAE.
Topics: Amphetamine; Amphetamines; Amygdala; Animals; Behavior, Animal; Brain; Desipramine; Imipramine; Nervous System Physiological Phenomena; Pharmacology; Rats; Research | 1964 |
COMPARATIVE ACTIVITIES OF A SUBSTITUTED DIBENZOTHIAZEPINE, OF IMIPRAMINE AND OF DESIPRAMINE.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Body Temperature; Cats; Desipramine; Dibenzothiazepines; Electroencephalography; Heart; Imipramine; Mice; Movement; Muscle, Smooth; Pharmacology; Rats; Research; Reserpine; Self Stimulation; Vomiting | 1964 |
EFFECT OF IMIPRAMINE AND SOME ANALOGUES ON THE UPTAKE OF 5-HYDROXYTRYPTAMINE BY HUMAN BLOOD PLATELETS IN VITRO.
Topics: Amitriptyline; Antidepressive Agents; Blood Platelets; Chlorpromazine; Desipramine; Humans; Imipramine; In Vitro Techniques; Metabolism; Orphenadrine; Pharmacology; Research; Serotonin | 1964 |
[THIN LAYER CHROMATOGRAPHIC SEPARATION OF PSYCHOPHARMACOLOGICAL AGENTS WITH ANTIDEPRESSIVE ACTION].
Topics: Amitriptyline; Antidepressive Agents; Chromatography; Chromatography, Thin Layer; Desipramine; Hydrazines; Imipramine; Iproniazid; Isocarboxazid; Isoniazid; Nialamide; Phenelzine; Research; Tranylcypromine | 1963 |
SOURCES OF VARIATION IN REPEATED MEASUREMENT OF PLASMA FREE FATTY ACIDS IN RESTED FASTING SUBJECTS.
Topics: Desipramine; Dietary Fats; Epinephrine; Fasting; Fatty Acids; Fatty Acids, Nonesterified; Imipramine; Lipids; Lysergic Acid Diethylamide; Mescaline; Pharmacology; Psilocybin; Reserpine; Tranquilizing Agents | 1964 |
COMPARISON OF DESIPRAMINE AND IMIPRAMINE IN DEPRESSION.
Topics: Biomedical Research; Depression; Depressive Disorder; Desipramine; Drug Therapy; Imipramine; Toxicology | 1964 |
[ON THE MECHANISM OF ACTION OF THE ANTIDEPRESSIVE AGENT IMIPRAMINE].
Topics: Antidepressive Agents; Desipramine; Humans; Imipramine; Pharmacology | 1964 |
[RESEARCH ON THE AMINE POTENTIATING EFFECT OF ANTIDEPRESSIVE AGENTS IN RABBITS].
Topics: Amines; Amitriptyline; Angiotensins; Antidepressive Agents; Desipramine; Epinephrine; Imipramine; Lysergic Acid Diethylamide; Norepinephrine; Pharmacology; Rabbits; Research; Serotonin; Thioridazine | 1964 |
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE.
Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervous System; Bradycardia; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Desipramine; Dogs; Epinephrine; Imipramine; Mice; Norepinephrine; Pharmacology; Promazine; Rats; Research; Reserpine; Sleep; Toxicology; Tranquilizing Agents; Vasomotor System; Yohimbine | 1964 |
[RESEARCH ON ANTICHOLINERGIC EFFECTS OF ANTIDEPRESSIVE SUBSTANCES IN THE RABBIT].
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Bradycardia; Cholinergic Antagonists; Desipramine; Imipramine; Parasympatholytics; Pharmacology; Rabbits; Research; Salivation; Sialorrhea | 1964 |
[PROGRESS OF DEPRESSIVE DISEASES UNDER DRUG THERAPY].
Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Drug Therapy; Humans; Imipramine; Nialamide; Prognosis; Psychopharmacology; Thioridazine | 1964 |
[ON PHARMACOLOGICAL STUDY OF ANTIDEPRESSIVES WITH REFERENCE TO A DIBENZODIAZEPINE].
Topics: Animals; Antidepressive Agents; Blood Pressure; Catalepsy; Desipramine; Electroencephalography; Epinephrine; Imipramine; Mice; Nictitating Membrane; Norepinephrine; Psychopharmacology; Rats; Research; Tetrabenazine | 1964 |
[THE ACTION OF 2 ANTIDEPRESSORS, IMIPRAMINE AND DESMETHYLIMIPRAMINE, ON THE HYPOTHALAMIC AND BULBAR VASOMOTOR CENTERS].
Topics: Cats; Desipramine; Electrophysiology; Hypothalamus; Imipramine; Medulla Oblongata; Pharmacology; Research; Splanchnic Nerves; Vasomotor System | 1964 |
EFFECT OF ALTERED THYROID STATUS ON DESMETHYLIMIPRAMINE MORTALITY IN MICE.
Topics: Desipramine; Hyperthyroidism; Imipramine; Mice; Propylthiouracil; Research; Toxicology | 1964 |
INHIBITION OF NORADRENALINE UPTAKE BY DRUGS.
Topics: Bretylium Compounds; Carbon Isotopes; Chlorpromazine; Cocaine; Desipramine; Guanethidine; Heart; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Pharmacology; Rats; Research; Reserpine; Sympatholytics | 1965 |
THE DIAGNOSIS AND MANAGEMENT OF DEPRESSION.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Classification; Depression; Depressive Disorder; Desipramine; Diagnosis; Drug Therapy; Humans; Imipramine; Monoamine Oxidase Inhibitors; Nortriptyline; Tyramine | 1965 |
POTENTIATION OF NOREPINEPHRINE IN THE ISOLATED VAS DEFERENS OF THE RAT BY SOME CNS STIMULANTS AND ANTIDEPRESSANTS.
Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Chlorpromazine; Chlorprothixene; Cocaine; Desipramine; Humans; Imipramine; Male; Methylphenidate; Norepinephrine; Pharmacology; Phenmetrazine; Piperidines; Rats; Research; Tranquilizing Agents; Vas Deferens | 1965 |
THE MANAGEMENT OF DEPRESSION IN HOSPITAL. A COMPARATIVE TRIAL OF DESIPRAMINE AND IMIPRAMINE.
Topics: Biomedical Research; Depression; Depressive Disorder; Desipramine; Drug Therapy; Humans; Imipramine; Pharmacology; Toxicology | 1965 |
CORRELATIONS BETWEEN EXPERIMENTAL AND CLINICAL RESULTS WITH ANTIDEPRESSANT DRUGS.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Dihydroxyphenylalanine; Imipramine; Pharmacology; Rabbits; Rats; Research; Reserpine; Tetrabenazine | 1965 |
ATTEMPT TO DIFFERENTIATE THYMOLEPTICS AND NEUROLEPTICS BY MEANS OF THEIR INFLUENCE ON THE EFFECTS OF RESERPINE.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Body Temperature; Chlorpromazine; Chlorprothixene; Desipramine; Eyelids; Imipramine; Mice; Nortriptyline; Peptic Ulcer; Pharmacology; Rats; Research; Reserpine; Toxicology; Tranquilizing Agents | 1964 |
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Induced; Imipramine; Injections, Intraperitoneal; Mice; Nortriptyline; Pentylenetetrazole; Peptic Ulcer; Rats; Research; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Strychnine; Toxicology; Tranquilizing Agents | 1965 |
A COMPARISON OF THE EFFECTS OF DESIPRAMINE AND IMIPRAMINE ON TWO SCHEDULES OF REINFORCEMENT.
Topics: Animals; Behavior, Animal; Desipramine; Equipment and Supplies; Imipramine; Pharmacology; Rats; Reinforcement, Psychology; Research | 1965 |
Desmethylimipramine (G-35020) in the treatment of depression, pilot study in a general hospital and outpatient setting.
Topics: Depression; Depressive Disorder; Desipramine; Hospitals, General; Imipramine; Outpatients; Pilot Projects | 1962 |
Preliminary investigation of desmethylimipramine (G 35020).
Topics: Depression; Depressive Disorder; Desipramine; Imipramine | 1962 |
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo.
Topics: Action Potentials; Adrenergic Uptake Inhibitors; Amygdala; Animals; Antidepressive Agents, Tricyclic; Binding, Competitive; Desipramine; Electrochemistry; Excitatory Amino Acid Antagonists; Fluoxetine; Humans; Imipramine; In Vitro Techniques; Locus Coeruleus; Male; Microelectrodes; Norepinephrine Plasma Membrane Transport Proteins; Pyridines; Radioligand Assay; Rats; Receptors, Kainic Acid; Symporters; Time Factors | 2003 |
In vitro microsomal metabolism of imipramine under conditions mimicking the in vivo steady-state situation.
Topics: Cytochrome P-450 Enzyme System; Desipramine; Hydroxylation; Imipramine; Microsomes, Liver; Models, Biological | 2004 |
Effects of antidepressants on the conformation of phospholipid headgroups studied by solid-state NMR.
Topics: Antidepressive Agents, Tricyclic; Benzylamines; Desipramine; Imipramine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Phospholipids | 2004 |
Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Depression; Desipramine; Imipramine; Male; Moclobemide; Monoamine Oxidase Inhibitors; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Swimming | 2004 |
Excess fatality from desipramine and dosage recommendations.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Databases, Factual; Desipramine; Drug Overdose; Humans; Imipramine; Nortriptyline; United Kingdom; United States | 2004 |
Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain.
Topics: Adult; Aged; Animals; Antidepressive Agents; Arrestins; beta-Arrestin 1; beta-Arrestins; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Depressive Disorder; Desipramine; Down-Regulation; Female; Fluvoxamine; Hippocampus; Humans; Imipramine; Leukocytes, Mononuclear; Male; Middle Aged; Psychiatric Status Rating Scales; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Severity of Illness Index | 2004 |
Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection.
Topics: Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Electrochemistry; Humans; Hydrogen-Ion Concentration; Imipramine; Micelles; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Different effects of desipramine on bufuralol 1''-hydroxylation by rat and human CYP2D enzymes.
Topics: Adult; Animals; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Desipramine; Ethanolamines; Humans; Hydroxylation; Imipramine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Middle Aged; Rats; Rats, Wistar; Species Specificity | 2005 |
An autopsy case of imipramine poisoning.
Topics: Antidepressive Agents, Tricyclic; Autopsy; Cause of Death; Chromatography, High Pressure Liquid; Desipramine; Drug Overdose; Female; Forensic Medicine; Forensic Pathology; Humans; Imipramine; Japan; Kidney Tubules; Middle Aged | 2005 |
Excess fatality from desipramine in children and adolescents.
Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; Nortriptyline; Prevalence; Substance-Related Disorders | 2006 |
Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Colonic Neoplasms; Desipramine; DNA Fragmentation; HT29 Cells; Humans; Imipramine; Membrane Potentials; Mitochondrial Membranes; Time Factors | 2006 |
Effect of antidepressant drugs on 6-OHDA-treated mice in the FST.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Cerebral Cortex; Citalopram; Depression; Desipramine; Dopamine Uptake Inhibitors; Hippocampus; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Mice; Neostriatum; Oxidopamine; Paroxetine; Swimming | 2007 |
Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents, Tricyclic; Basilar Artery; Biogenic Monoamines; Cells, Cultured; Cerebrovascular Circulation; Desipramine; Dose-Response Relationship, Drug; Female; Imipramine; Male; Metabolic Clearance Rate; Neurons; Nitric Oxide; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Superior Cervical Ganglion; Swine; Vasodilation; Xenopus laevis | 2006 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liquid; Desipramine; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Imipramine; Lamotrigine; Nortriptyline; Phenobarbital; Phenylethylmalonamide; Polyurethanes; Primidone; Reproducibility of Results; Sensitivity and Specificity; Silanes; Time Factors; Triazines | 2006 |
Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Citalopram; Desipramine; Drug Interactions; Imipramine; Male; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Phenols; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulfonamides; Swimming | 2007 |
Delayed effects of antidepressant drugs in rats.
Topics: Adrenergic beta-Agonists; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Citalopram; Desipramine; Imipramine; Male; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Selective Serotonin Reuptake Inhibitors; Swimming | 2006 |
Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies.
Topics: Age Factors; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Imipramine; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Swimming; Time Factors | 2007 |
The effect of beta-cyclodextrin on liquid chromatography/electrospray-mass spectrometry analysis of hydrophobic drug molecules.
Topics: Antidepressive Agents, Tricyclic; beta-Cyclodextrins; Chromatography, High Pressure Liquid; Desipramine; Imipramine; Reference Standards; Spectrometry, Mass, Electrospray Ionization | 2007 |
Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients.
Topics: Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Genotype; Humans; Imipramine; Polymorphism, Single Nucleotide; Predictive Value of Tests; Retrospective Studies | 2008 |
Fast urinary screening for imipramine and desipramine using on-line solid-phase extraction and selective derivatization.
Topics: Antidepressive Agents, Tricyclic; Desipramine; Humans; Hydrogen-Ion Concentration; Imipramine; Online Systems; Solid Phase Extraction | 2007 |
Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram.
Topics: Animals; Antidepressive Agents; Citalopram; Desipramine; Imipramine; Male; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin Plasma Membrane Transport Proteins | 2007 |
Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Chromatography, Liquid; Clomipramine; Desipramine; Humans; Imipramine; Nortriptyline; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization | 2007 |
In vitro biotransformation of amitriptyline and imipramine with rat hepatic S9 fraction: evaluation of the toxicity with Spirotox and Thamnotoxkit F Tests.
Topics: Amitriptyline; Animals; Anostraca; Biotransformation; Ciliophora; Desipramine; Imipramine; Lethal Dose 50; Liver; Male; Nortriptyline; Rats; Rats, Sprague-Dawley; Toxicity Tests; Water Pollutants, Chemical | 2008 |
Automated classification of the behavior of rats in the forced swimming test with support vector machines.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Electronic Data Processing; Imipramine; Male; Motor Activity; Neural Networks, Computer; Rats; Rats, Wistar; Reproducibility of Results; Spectrum Analysis; Swimming | 2008 |
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Topics: Adolescent; Age Factors; Animals; Antidepressive Agents; Child; Citalopram; Depressive Disorder; Desipramine; Disease Models, Animal; Escape Reaction; Fluoxetine; Helplessness, Learned; Humans; Imipramine; Injections, Intraperitoneal; Male; Motivation; Rats; Rats, Sprague-Dawley; Swimming; Tranylcypromine | 2008 |
Efficacy of imipramine in psychotic versus nonpsychotic depression.
Topics: Adult; Affective Disorders, Psychotic; Aged; Antidepressive Agents; Data Interpretation, Statistical; Depressive Disorder; Desipramine; Diagnostic and Statistical Manual of Mental Disorders; Drug Administration Schedule; Drug Therapy, Combination; Female; Haloperidol; Humans; Imipramine; Logistic Models; Lorazepam; Male; Middle Aged; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome | 2008 |
Pharmacokinetic and pharmacodynamic studies of drug interaction following oral administration of imipramine and sodium alginate in rats.
Topics: Administration, Oral; Alginates; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Depression; Desipramine; Dietary Fiber; Disease Models, Animal; Drug Interactions; Glucuronic Acid; Hexuronic Acids; Imipramine; Intestinal Absorption; Male; Rats; Rats, Wistar; Swimming | 2008 |
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Chronic Disease; Depression; Desipramine; Fluoxetine; Grooming; Imipramine; Injections, Intraperitoneal; Male; Maprotiline; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Selective Serotonin Reuptake Inhibitors; Species Specificity; Stress, Psychological; Time Factors | 2008 |
Micronuclei induced by imipramine and desipramine in mice: a subchronic study.
Topics: Animals; Antidepressive Agents, Tricyclic; Bone Marrow Cells; Desipramine; Imipramine; Male; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitosis | 2008 |
Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Citalopram; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fatigue Syndrome, Chronic; Imipramine; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Oxidative Stress; Swimming | 2009 |
Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain Ischemia; Cyclopropanes; Depressive Disorder; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fluvoxamine; Hippocampus; Imipramine; Immobility Response, Tonic; Male; Milnacipran; Motor Activity; Rats; Rats, Wistar | 2009 |
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; Cyclopropanes; Desipramine; Fluoxetine; Fluvoxamine; Glutamine; HeLa Cells; Humans; Imipramine; Milnacipran; Morpholines; Paroxetine; Reboxetine; Receptors, AMPA; RNA Editing; RNA-Binding Proteins; RNA, Messenger | 2009 |
Comparison of fused-core and conventional particle size columns by LC-MS/MS and UV: application to pharmacokinetic study.
Topics: Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Chromatography, Liquid; Desipramine; Imipramine; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors | 2009 |
The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Depression; Desipramine; Genotype; Humans; Imipramine; Middle Aged; Multivariate Analysis | 2010 |
Chromosomal aberrations induced by imipramine and desipramine in mouse.
Topics: Animals; Antidepressive Agents, Tricyclic; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Desipramine; Dose-Response Relationship, Drug; Imipramine; Male; Mice | 2010 |
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase | 2010 |
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition.
Topics: Animals; Antidepressive Agents; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Desipramine; Diazepam; Dopamine Uptake Inhibitors; Fluvoxamine; Haloperidol; Imipramine; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 2011 |
Automated experimental system capturing three behavioral components during murine forced swim test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Animal; Bupropion; Desipramine; Equipment Design; Fluvoxamine; Image Interpretation, Computer-Assisted; Imipramine; Male; Mice; Mice, Inbred Strains; Pattern Recognition, Automated; Psychomotor Performance; Swimming; Video Recording | 2011 |
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride | 2010 |
Antidepressants elevate GDNF expression and release from C₆ glioma cells in a β-arrestin1-dependent, CREB interactive pathway.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Arrestins; beta-Arrestins; Brain Neoplasms; Cell Line, Tumor; Citalopram; Cyclic AMP Response Element-Binding Protein; Desipramine; Dose-Response Relationship, Drug; Glial Cell Line-Derived Neurotrophic Factor; Glioblastoma; Haloperidol; Imipramine; Neurotransmitter Uptake Inhibitors; Phosphorylation; Rats; RNA Interference; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Transcription, Genetic; Transfection; Up-Regulation; Valproic Acid | 2011 |
IFN-gamma reduction by tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytokines; Depressive Disorder; Desipramine; Desvenlafaxine Succinate; Female; Humans; Imipramine; In Vitro Techniques; Interferon-gamma; Male; Nortriptyline; Venlafaxine Hydrochloride | 2010 |
Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Anxiety; Autoradiography; Brain; Desipramine; Disease Models, Animal; Drug Delivery Systems; Exploratory Behavior; Feeding Behavior; Imipramine; Immobility Response, Tonic; Male; Neural Pathways; Norepinephrine; Oxidopamine; Protein Binding; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Antagonists; Sertraline; Swimming; Time Factors; Tritium; Vagus Nerve Stimulation | 2011 |
Evaluation of the potential of surface enhancement Raman spectroscopy for detection of tricyclic psychotropic drugs. Case studies on imipramine and its metabolite.
Topics: Antidepressive Agents, Tricyclic; Desipramine; Humans; Imipramine; Spectrum Analysis, Raman; Surface Properties | 2011 |
Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.
Topics: Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blood-Brain Barrier; Cyclosporine; Desipramine; Drug Interactions; Extracellular Fluid; Half-Life; Imipramine; Injections, Intravenous; Male; Metabolic Clearance Rate; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2012 |
Simultaneous generation of binary and normal data with specified marginal and association structures.
Topics: Algorithms; Computer Simulation; Data Interpretation, Statistical; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Longitudinal Studies; Male; Models, Statistical; Treatment Outcome | 2012 |
Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode.
Topics: Adsorption; Antidepressive Agents, Tricyclic; Carbon; Desipramine; Electrochemical Techniques; Electrodes; Humans; Imipramine; Limit of Detection; Nanoparticles; Pharmaceutical Preparations; Reproducibility of Results; Resins, Synthetic; Titanium; Trimipramine | 2013 |
A proposal for refining the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramine; Disease Models, Animal; Fluoxetine; Imipramine; Immobility Response, Tonic; Male; Mice; Principal Component Analysis; Swimming; Time Factors | 2013 |
Antidepressants share the ability to increase catecholamine output in the bed nucleus of stria terminalis: a possible role in antidepressant therapy?
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bupropion; Citalopram; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Male; Morpholines; Norepinephrine; Rats, Sprague-Dawley; Reboxetine; Septal Nuclei; Time Factors | 2014 |
Tricyclic antidepressants exhibit variable pharmacological profiles at the α(2A) adrenergic receptor.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrestins; Desipramine; Endocytosis; HEK293 Cells; Humans; Imipramine; Mice; Receptors, Adrenergic, alpha-2 | 2014 |
Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS).
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Nortriptyline; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.
Topics: Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Imipramine; Limit of Detection; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Reproducibility of Results | 2016 |
Liquid-Phase Microextraction and Gas Chromatographic-Mass Spectrometric Analysis of Antidepressants in Vitreous Humor: Study of Matrix Effect of Human and Bovine Vitreous and Saline Solution.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cattle; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Liquid Phase Microextraction; Sodium Chloride; Vitreous Body | 2016 |
The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Topics: Antidepressive Agents, Tricyclic; Area Under Curve; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Desipramine; Hepatocytes; Humans; Imipramine; In Vitro Techniques; Microsomes, Liver; Models, Biological; Tandem Mass Spectrometry | 2016 |
Effect of Cytochrome P450 (CYP) 2D6 Genetic Polymorphism on the Inhibitory Action of Antidepressants on CYP2D6-Mediated Dopamine Formation from p-Tyramine.
Topics: Antidepressive Agents; Brain; Cytochrome P-450 CYP2D6; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluvoxamine; Humans; Imipramine; Polymorphism, Genetic; Structure-Activity Relationship; Tyramine | 2018 |
Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis.
Topics: Antidepressive Agents; Cell Line, Tumor; Desipramine; Fluoxetine; Humans; Imipramine; Lysosomes; Phospholipids; Sphingomyelin Phosphodiesterase | 2018 |
β-Cyclodextrin Inclusion Complexation With Tricyclic Antidepressants Desipramine and Imipramine: A Structural Chemistry Perspective.
Topics: Antidepressive Agents, Tricyclic; beta-Cyclodextrins; Desipramine; Imipramine; Nortriptyline | 2020 |
Time-course of changes in key catecholaminergic receptors and trophic systems in rat brain after antidepressant administration.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Citalopram; Desipramine; Imipramine; Male; Membrane Proteins; Rats; Receptor, trkB; Receptors, Adrenergic; Receptors, Catecholamine; Receptors, Dopamine | 2020 |
Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Desipramine; Fluoxetine; Gene Expression Regulation; Humans; Imipramine; Mianserin; Mice; PC12 Cells; Rats; Reboxetine; Receptors, Adrenergic, alpha-1; Signal Transduction | 2021 |
An approach to evaluate metabolite-related phototoxicity with combined use of photochemical properties and skin deposition.
Topics: Administration, Oral; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Desipramine; Imipramine; Oxidants, Photochemical; Reactive Oxygen Species; Ultraviolet Rays | 2021 |
Effects of the LC mobile phase in vacuum differential mobility spectrometry-mass spectrometry for the selective analysis of antidepressant drugs in human plasma.
Topics: Acetonitriles; Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Maprotiline; Mass Spectrometry; Methanol; Nortriptyline; Reproducibility of Results; Spectrum Analysis; Vacuum; Venlafaxine Hydrochloride | 2022 |
On-Chip Electromembrane Surrounded Solid Phase Microextraction for Determination of Tricyclic Antidepressants from Biological Fluids Using Poly(3,4-ethylenedioxythiophene)-Graphene Oxide Nanocomposite as a Fiber Coating.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Humans; Imipramine; Limit of Detection; Maprotiline; Nanocomposites; Nortriptyline; Reproducibility of Results; Sertraline; Solid Phase Microextraction | 2023 |
Polycarbonate-coated magnetic nanoparticles for the extraction of imipramine and its primary metabolite from urine.
Topics: Chromatography, High Pressure Liquid; Desipramine; Imipramine; Magnetic Phenomena; Magnetite Nanoparticles; Solid Phase Extraction | 2023 |