imipramine has been researched along with clonidine in 151 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (35.76) | 18.7374 |
| 1990's | 21 (13.91) | 18.2507 |
| 2000's | 28 (18.54) | 29.6817 |
| 2010's | 46 (30.46) | 24.3611 |
| 2020's | 2 (1.32) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, TH; Ganellin, CR; Griffiths, R; Jones, M; Mitchell, RC; Rana, KK; Saunders, D; Smith, IR; Sore, NE; Young, RC | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Akamatsu, M | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM | 1 |
| Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM | 1 |
| Andrisano, V; Bartolini, M; Clos, MV; Di Pietro, O; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Ramón, R; Viayna, E; Vicente-García, E | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Juárez-Jiménez, J; Lavilla, R; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sabaté, R | 1 |
| Clos, MV; Di Pietro, O; Espargaró, A; Galdeano, C; Guillou, C; Lamuela-Raventós, RM; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Ragusa, IM; Sabaté, R; Vallverdú-Queralt, A; Viayna, E | 1 |
| Artigas, A; Clos, MV; Gbedema, SY; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Sola, I; Taylor, MC; Wright, CW | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Berenguer, D; Clos, MV; Di Pietro, O; Fisa, R; Kelly, JM; Lanzoni, A; Lavilla, R; Muñoz-Torrero, D; Pérez, B; Riera, C; Sayago, H; Sola, I; Taylor, MC; Viayna, E; Vicente-García, E | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Alencar, N; Di Pietro, O; Esteban, G; Juárez-Jiménez, J; Luque, FJ; Muñoz-Torrero, D; Pérez, B; Sola, I; Solé, M; Szałaj, N; Unzeta, M; Vázquez, J; Viayna, E | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Artigas, A; Clos, MV; Kelly, JM; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Sola, I; Taylor, MC; Viayna, E; Wright, CW | 1 |
| Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Huang, Q; Jiang, N; Li, Q; Liang, N; Liu, J; Xie, SS | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Andrisano, V; Barniol-Xicota, M; Bartolini, M; De Simone, A; Espargaró, A; Muñoz-Torrero, D; Pérez, B; Pérez-Areales, FJ; Pivetta, D; Pont, C; Sabate, R; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Bhalla, M; Kumar, R; Malhotra, V; Mehta, S; Nath, R; Pathak, SR; Shanker, K; Sinha, JN; Vats, M | 1 |
| Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S | 1 |
| Bhattacharya, BK; Dadkar, NK; Dohadwalla, AN | 1 |
| Lisciani, R; Silvestrini, B | 1 |
| Klimek, V; Maj, J; Mogilnicka, E | 1 |
| Gold, MS; Kleber, HD; Pottash, AL; Redmond, DE; Sweeney, DR | 1 |
| Ozawa, H; Uematsu, T | 1 |
| Poignant, JC; Rismondo, N | 1 |
| Grewal, RS; Kaul, CL | 1 |
| Hayakawa, H; Shimizu, M; Yamawaki, S | 1 |
| Mustafa, AA | 1 |
| Cassinadri, M; Ferrari, F; Tampieri, A; Tartoni, PL | 1 |
| Hayakawa, H; Shimizu, M; Sugihara, J; Yamawaki, S | 1 |
| Cai, B; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H | 1 |
| Ferrari, RA; Hamel, LT; Haubrich, DR; Perrone, MH | 1 |
| Ferraino, R; Fritz, PM; Hamel, LT; Haubrich, DR; Luttinger, D; Perrone, MH | 1 |
| Gilaberte, I; Iruela, LM; Oliveros, SC; Rojo, VI | 1 |
| Leeman, CP | 1 |
| Fellhauer, M | 1 |
| Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC | 1 |
| Gelenberg, AJ; Lydiard, RB; Wolfe, N | 1 |
| Harada, T; Otsuki, S; Takeda, T | 1 |
| Borbe, HO; Brune, K; Nickel, B; Szelenyi, I | 1 |
| Ballejo, G; Calixto, JB; Strobel, GH | 1 |
| Kinzie, JD; Leung, P | 1 |
| File, SE; Pellow, S | 1 |
| Carstens, ME; Engelbrecht, AH; Russell, VA; Taljaard, JJ; van Zyl, AM | 1 |
| Müller, WE; Rick-Brand, S | 1 |
| Asakura, M; Tsukamoto, T | 1 |
| Fujita, M; Horikomi, K | 1 |
| Harris, JC; Newman, JD | 1 |
| Keith, RA; Salama, AI | 1 |
| Braquet, P; Brunello, N; Clostre, F; Drieu, K; Racagni, G | 1 |
| Davies, SL; Hale, AS; Horton, RW; Katona, CL; Kelly, JS; Paykel, ES; Theodorou, AE; Tunnicliffe, C; Yamaguchi, Y | 1 |
| Arbilla, S; Bartholini, G; Claustre, Y; Dedek, J; Dennis, T; Langer, SZ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Armour, M; Friedhoff, AJ; Georgotas, A; McCue, RE; Schweitzer, J | 1 |
| Bamford, CR; Sandyk, R | 1 |
| Garattini, S; Mennini, T; Mocaer, E | 1 |
| Cohen, BS; Dillon, D; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR | 1 |
| Okpanyi, SN; Weischer, ML | 1 |
| Hashizume, H; Ito, C; Niho, T; Shibutani, Y; Yamaguchi, K | 1 |
| Quenzer, LF; Yurko, KA | 1 |
| Hoefke, W; Warnke-Sachs, E | 1 |
| van Spanning, HW; van Zwieten, PA | 1 |
| Lackner, F | 1 |
| Cameron, OG; Curtis, GC; Hollingsworth, PJ; Nesse, RM; Smith, CB | 1 |
| Liebowitz, MR | 1 |
| Lane, EA; Potter, WZ; Rudorfer, MV | 1 |
| Svensson, TH | 1 |
| Cohen, RM; Murphy, DL; Siever, LJ | 1 |
| García-Sevilla, JA; Greden, JF; Hollingsworth, PJ; Smith, CB; Zis, AP | 1 |
| Pilc, A; Vetulani, J | 1 |
| Cameron, OG; Garcia-Sevilla, JA; Smith, CB; Zelnik, TC | 1 |
| Scuvée-Moreau, JJ; Svensson, TH | 1 |
| de Carolis, AS; Passarelli, F | 1 |
| Cloutier, G; Cubeddu, LX; Grippo, R; Gross, K; Harden, TK; Knowlton, G; Lerea, L; Shakarjian, M; Stat, M; Tanner, L | 1 |
| Sternberg, DE | 1 |
| Gillin, JC; Insel, TR; Mueller, EA; Murphy, DL; Siever, LJ | 1 |
| Passarelli, F; Scotti de Carolis, A | 1 |
| Anderson, S; Appleby, IL; Davies, SO; Dillon, D; Fyer, AJ; Gorman, JM; Levitt, M; Levy, G; Liebowitz, MR; Palij, M | 1 |
| Hui, KK | 1 |
| Elsworth, JD; Ko, GN; Leigh, H; Redmond, DE; Rifkin, BG; Roth, RH | 1 |
| Broekkamp, CL; Garrigou, D; LLoyd, KG | 1 |
| Mogilnicka, E | 1 |
| Górka, Z; Zacny, E | 1 |
| Campbell, M; Cueva, JE | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S | 1 |
| Abel, EL | 1 |
| Amabeoku, G; Chandomba, R | 1 |
| Black, BC; Cannon, RO; Geraci, MF; Gracely, RH; Mincemoyer, R; Quyyumi, AA; Smith, WB; Stine, AM; Uhde, TW; Waclawiw, MA | 1 |
| Amabeoku, GJ | 1 |
| Arora, RC; Crayton, J; Gulati, A | 1 |
| Barrett, JE; Sasaki, JE; Tatham, TA | 1 |
| Honda, N; Iwasaka, H; Oyama, T; Taniguchi, K; Yoshitake, S | 1 |
| Artigas, F; Bel, N | 1 |
| Halaris, A; Piletz, JE; Zhu, H | 1 |
| Dlaboga, D; Dziedzicka-Wasylewska, M; Góralska, M; Margas, W; Rogóz, Z | 1 |
| Sahebgharani, M; Zarrindast, MR | 1 |
| Ghiasvand, M; Homayoun, H; Khavandgar, S; Rostami, P; Shafaghi, B; Zarrindast, MR | 1 |
| Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Rogóz, Z; Solich, J | 1 |
| France, CP; Koek, W; McMahon, LR; Sell, SL | 1 |
| Banaschewski, T; Heise, CA; Himpel, S; Rothenberger, A | 1 |
| Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE | 1 |
| Hymel, KA; Sufka, KJ | 1 |
| Holland, MG; Marraffa, JM; Ryzewski, M; Sullivan, RW | 1 |
| Hainz, N; Kovačević, B; Meier, C; Rzagalinski, I; Tschernig, T; Volmer, DA | 1 |
7 review(s) available for imipramine and clonidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Antidepressant drugs and central monoaminergic receptors].
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Antipsychotic Agents; Binding Sites; Blood Platelets; Brain; Brain Chemistry; Cats; Clonidine; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Mianserin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Yohimbine | 1985 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Monoamine Oxidase Inhibitors; Personality Disorders; Phenelzine; Propranolol; Psychotropic Drugs; Schizophrenia | 1982 |
Effect of chronic treatment with tricyclic antidepressant drugs on identified brain noradrenergic and serotonergic neurons.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Clonidine; Drug Interactions; Imipramine; Iontophoresis; Lysergic Acid Diethylamide; Male; Neurons; Norepinephrine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Serotonin; Yohimbine | 1980 |
Biologic tests in psychiatry.
Topics: Anxiety Disorders; Apomorphine; Clonidine; Dexamethasone; Dextroamphetamine; Growth Hormone; Humans; Hydrocortisone; Imipramine; Lactates; Mental Disorders; Mood Disorders; Panic; Prognosis; Schizophrenia; Serotonin; Thyrotropin-Releasing Hormone | 1984 |
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonidine; Clozapine; Depressive Disorder; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Fluoxetine; Humans; Imipramine; Lithium; Mutism; Obsessive-Compulsive Disorder; Phenobarbital; Phenytoin; Phobic Disorders; Schizophrenia; Sleep Wake Disorders; Tranquilizing Agents | 1995 |
The safety of non-stimulant agents for the treatment of attention-deficit hyperactivity disorder.
Topics: Adrenergic alpha-Agonists; Adult; Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; Clonidine; Desipramine; Guanfacine; Humans; Imipramine; Nortriptyline; Propylamines | 2005 |
6 trial(s) available for imipramine and clonidine
| Article | Year |
|---|---|
Alpha 2-adrenergic receptor sensitivity in depressed patients: relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension.
Topics: Adult; Blood Platelets; Blood Pressure; Cell Membrane; Clinical Trials as Topic; Clonidine; Depressive Disorder; Double-Blind Method; Female; Humans; Hypotension; Imipramine; Male; Middle Aged; Receptors, Adrenergic; Tyrosine; Yohimbine | 1989 |
Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients.
Topics: Blood Platelets; Carrier Proteins; Clonidine; Depressive Disorder; Double-Blind Method; Humans; Imidazoline Receptors; Imipramine; Kinetics; Middle Aged; Nortriptyline; Phenelzine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Neurotransmitter | 1987 |
Bupropion does not antagonize cardiovascular actions of clonidine in normal subjects and spontaneously hypertensive rats.
Topics: Adult; Animals; Blood Platelets; Blood Pressure; Bupropion; Clonidine; Desipramine; Heart Rate; Humans; Imipramine; In Vitro Techniques; Male; Propiophenones; Rats; Rats, Inbred Strains; Tritium; Yohimbine | 1984 |
Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine.
Topics: Adult; Anxiety Disorders; Clonidine; Double-Blind Method; Fear; Female; Glycols; Humans; Imipramine; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Panic; Personality Inventory; Phobic Disorders; Syndrome | 1983 |
Imipramine in patients with chest pain despite normal coronary angiograms.
Topics: Adult; Aged; Chest Pain; Chronic Disease; Clonidine; Coronary Angiography; Coronary Disease; Double-Blind Method; Electrocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Imipramine; Male; Middle Aged | 1994 |
The effects of imipramine, amitriptyline and clonidine administered by iontophoresis on the pain threshold.
Topics: Adrenergic alpha-Agonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clonidine; Humans; Imipramine; Iontophoresis; Pain; Sensory Thresholds | 1995 |
138 other study(ies) available for imipramine and clonidine
| Article | Year |
|---|---|
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists.
Topics: Algorithms; Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry, Physical; Clonidine; Guinea Pigs; Histamine H2 Antagonists; Imipramine; Pyrilamine; Structure-Activity Relationship | 1988 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine | 2011 |
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding | 2012 |
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Topics: Acetylcholinesterase; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Membranes, Artificial; Models, Biological; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Naphthyridines; Permeability; Protein Binding | 2014 |
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Structure-Activity Relationship; Tacrine; tau Proteins; Tauopathies | 2014 |
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Topics: Acetylcholinesterase; Aminoquinolines; Amyloid beta-Peptides; Antioxidants; Catechols; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; tau Proteins | 2014 |
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Topics: Antimalarials; Antiprotozoal Agents; Humans; Molecular Structure; Structure-Activity Relationship | 2014 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Topics: Acetylcholinesterase; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Leishmania infantum; Molecular Structure; Parasitic Sensitivity Tests; Quinolines; Rats; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma cruzi | 2015 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Structure-Activity Relationship | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Topics: Aminoquinolines; Brain; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2016 |
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).
Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Aggregates; Range of Motion, Articular; Structure-Activity Relationship; Thiocarbamates | 2018 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tacrine | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents.
Topics: Animals; Antihypertensive Agents; Central Nervous System Agents; Depression; Female; Hypertension; Imidazolines; Male; Pain; Rats | 2020 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate | 2022 |
Role of peripheral vascular resistance and reactivity in the interaction between clonidine and imipramine in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Hypertension; Imipramine; Male; Rats; Vascular Resistance | 1978 |
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, Inbred Strains; Nicotine; Oxotremorine; Parkinson Disease, Secondary; Phenoxybenzamine; Piloerection; Pyrilamine; Rabbits; Salivation; Sympathetic Nervous System; Trazodone; Tremor | 1976 |
The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonists.
Topics: Amitriptyline; Animals; Antidepressive Agents; Clonidine; Dextroamphetamine; Imipramine; Male; Mianserin; Motor Activity; Rats | 1979 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Methadone; Narcotics; Panic; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
[Mode of action of clonidine, a central hypotensive agent, analyzed by the interaction with various sympathomimetic agents].
Topics: Animals; Blood Pressure; Central Nervous System; Chlorpromazine; Clonidine; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; Ephedrine; Guanethidine; Guinea Pigs; Haloperidol; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Male; Methamphetamine; Norepinephrine; Rats; Sympathomimetics; Tyramine; Vas Deferens | 1975 |
[Influence of the administration of psychopharmacological compounds on the take up time of an alimentary material in the hamster and a study of the associated behaviour (author's transl)].
Topics: Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clonidine; Cricetinae; Dextroamphetamine; Diazepam; Feeding Behavior; Fenfluramine; Humans; Imipramine; Male; Meprobamate; Mesocricetus; Morphine; Motor Activity; Phenobarbital; Piribedil; Psychotropic Drugs; Stereotyped Behavior; Sulpiride; Time Factors | 1975 |
Antagonism of antihypertensive effect of clonidine by imipramine & desmethylimipramine in renal hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Desipramine; Hypertension, Renal; Imipramine; Rats | 1975 |
The effects of electroconvulsive shock or imipramine on subtypes of alpha 1-adrenoceptors in the frontal cortex of the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Clonidine; Dioxanes; Electroshock; Hippocampus; Imipramine; In Vitro Techniques; Kinetics; Male; Prazosin; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1992 |
Rapid desensitization of central beta-adrenoceptors in rat after subacute treatment with imipramine and calcium entry blockers.
Topics: 1-Propanol; Animals; Calcium Channel Blockers; Clonidine; Diltiazem; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drinking Behavior; Fenclonine; Imipramine; Isoproterenol; Ketanserin; Nicardipine; Nifedipine; Oxidopamine; Rats; Receptors, Adrenergic, beta; Verapamil | 1991 |
Effects of B-HT 920 in the tail-suspension test.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Azepines; Clonidine; Depressive Disorder; Dopamine Agents; Imipramine; Male; Mice; Motor Activity; Yohimbine | 1991 |
Effects of repeated treatment with electro-convulsive shock and imipramine on serotonin2 receptor functions.
Topics: Animals; Arousal; Behavior, Animal; Clonidine; Electroshock; Frontal Lobe; Imipramine; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1991 |
Desipramine enhances isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; Clonidine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Activity; Phentolamine; Prazosin; Social Isolation; Yohimbine | 1991 |
Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Brain; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Prazosin; Rats; Receptors, Adrenergic, alpha; Synaptosomes; Vas Deferens | 1990 |
In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor.
Topics: Adrenergic alpha-Antagonists; Animals; Blepharoptosis; Brain; Clonidine; Conditioning, Operant; Desipramine; Drug Interactions; Imidazoles; Imipramine; Male; Mice; Norepinephrine; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Serotonin; Tetrabenazine | 1990 |
Clonidine-imipramine therapy.
Topics: Adult; Anxiety Disorders; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Imipramine; Panic | 1991 |
Pathophysiology of tricyclic-induced sweating.
Topics: Adult; Clonidine; Female; Humans; Hyperhidrosis; Imipramine; Receptors, Adrenergic; Sweating | 1990 |
[Drug treatment of nicotine dependence].
Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndrome | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors | 1988 |
Platelet 3H-clonidine and 3H-imipramine binding and plasma cortisol level in depression.
Topics: Adult; Aged; Blood Platelets; Carrier Proteins; Clonidine; Depressive Disorder; Dexamethasone; Female; Humans; Imidazoline Receptors; Imipramine; Male; Middle Aged; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Neurotransmitter | 1989 |
Mode of antinociceptive action of flupirtine in the rat.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Aminopyridines; Analgesics; Animals; Brain Chemistry; Clonidine; Imipramine; Male; Methyltyrosines; Neurotoxins; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Neurotransmitter; Reserpine; Serotonin Antagonists | 1989 |
Decreased gamma-aminobutyric acid (GABA) modulatory effect on rat vas deferens neurotransmission after chronic administration of imipramine.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Imipramine; Isoproterenol; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptic Transmission; Vas Deferens | 1989 |
Clonidine in Cambodian patients with posttraumatic stress disorder.
Topics: Adult; Cambodia; Clonidine; Depressive Disorder; Drug Combinations; Female; Humans; Imipramine; Male; Middle Aged; Mood Disorders; Pilot Projects; Prospective Studies; Refugees; Stress Disorders, Post-Traumatic | 1989 |
Can anti-panic drugs antagonise the anxiety produced in the rat by drugs acting at the GABA-benzodiazepine receptor complex?
Topics: Animals; Anxiety; Carbolines; Clonidine; Fear; Imipramine; Male; Panic; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Social Behavior | 1987 |
Biological markers in juvenile depression.
Topics: Adolescent; Blood Platelets; Carrier Proteins; Child; Clonidine; Depressive Disorder; Dihydroalprenolol; Humans; Imipramine; Lymphocytes; Receptors, Adrenergic; Receptors, Drug; Receptors, Neurotransmitter | 1988 |
Direct and indirect effects of alprazolam and imipramine on alpha 1- and alpha 2-adrenoceptors in mouse forebrain.
Topics: Alprazolam; Animals; Binding, Competitive; Brain Chemistry; Clonidine; Imipramine; Male; Mice; Prazosin; Receptors, Adrenergic, alpha | 1988 |
[Comparative study of the pharmacological properties of sultopride sulpiride and other antipsychotic drugs: influence of sultopride, sulpiride and other antipsychotic drugs on spontaneous locomotor activity and changes in locomotor activity induced by apo
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Chlorpromazine; Clonidine; Drug Interactions; Haloperidol; Imipramine; Male; Mice; Motor Activity; Pimozide; Sulpiride; Yohimbine | 1986 |
Mediation of separation distress by alpha 2-adrenergic mechanisms in a non-human primate.
Topics: Adrenergic alpha-Agonists; Animals; Anxiety, Separation; Clonidine; Imipramine; Male; Prazosin; Receptors, Adrenergic, alpha; Saimiri; Vocalization, Animal; Yohimbine | 1987 |
Inhibition of presynaptic alpha-2-adrenoceptor and opioid receptor agonist responses in the rat vas deferens by chronic imipramine treatment.
Topics: Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Imipramine; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Parasympathomimetics; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Vas Deferens | 1987 |
Effects of an extract of Ginkgo biloba on noradrenergic systems of rat cerebral cortex.
Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Imipramine; Kinetics; Male; Norepinephrine; Normetanephrine; Plant Extracts; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1985 |
Platelet radioligand binding and neuroendocrine challenge tests in depression.
Topics: Adult; Binding Sites; Blood Platelets; Blood Pressure; Clonidine; Depression; Female; Growth Hormone; Heart Rate; Humans; Imipramine; Male; Middle Aged; Radioligand Assay; Receptors, Adrenergic, alpha; Serotonin; Yohimbine | 1986 |
Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat.
Topics: Animals; Antidepressive Agents; Brain; Chlorophenols; Clonidine; Dihydroalprenolol; gamma-Aminobutyric Acid; Imipramine; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin; Spiperone; Synaptic Transmission | 1987 |
Beneficial effects of imipramine on Tourette's syndrome.
Topics: Child; Clonidine; Female; Haloperidol; Humans; Imipramine; Tourette Syndrome | 1988 |
Tianeptine, a selective enhancer of serotonin uptake in rat brain.
Topics: Animals; Brain; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dopamine; Hippocampus; Imipramine; In Vitro Techniques; Male; Mesencephalon; Norepinephrine; Rats; Serotonin; Spiperone; Synaptosomes; Thiazepines | 1987 |
Antipanic drug effects during lactate infusion in lactate-refractory panic patients.
Topics: Adult; Agoraphobia; Alprazolam; Clonidine; Desipramine; Fear; Female; Fluoxetine; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic; Phobic Disorders; Psychological Tests; Psychotropic Drugs | 1987 |
[Animal experiments on the psychotropic action of a Hypericum extract].
Topics: Aggression; Animals; Clonidine; Imipramine; Male; Mice; Plant Extracts; Psychotropic Drugs; Reserpine; Sleep; Temperature | 1987 |
[Pharmacological properties of MO-8282, a novel antidepressant].
Topics: Aggression; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Amines; Brain; Clonidine; Guinea Pigs; Imipramine; Male; Mianserin; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Reserpine; Tremorine | 1986 |
Stimulation of 3H-norepinephrine release by trifluoperazine from rat pineal glands.
Topics: Animals; Calcium; Clonidine; Dose-Response Relationship, Drug; Imipramine; In Vitro Techniques; Male; Norepinephrine; Pineal Gland; Potassium; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trifluoperazine; Yohimbine | 1986 |
Influence of desmethylimipramine on the hypotensive effect of clonidine.
Topics: Animals; Blood Pressure; Clonidine; Drug Interactions; Female; Imipramine; Injections, Intravenous; Male; Rabbits | 1974 |
The interference of tricyclic antidepressants with the central hypotensive effect of clonidine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Cats; Clonidine; Desipramine; Imipramine; Time Factors | 1973 |
[Experiences with clonidine with simultaneous psychopharmacologic medication].
Topics: Blood Pressure; Clonidine; Drug Interactions; Humans; Imipramine; Pilocarpine | 1974 |
Platelet alpha 2-adrenergic receptor binding and plasma catecholamines. Before and during imipramine treatment in patients with panic anxiety.
Topics: Adolescent; Adult; Anxiety Disorders; Blood Platelets; Catecholamines; Clonidine; Dopamine; Epinephrine; Fear; Female; Humans; Imipramine; Male; Norepinephrine; Panic; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Active metabolites of antidepressants: pharmacodynamics and relevant pharmacokinetics.
Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Asian People; Biotransformation; Clonidine; Desipramine; Female; Humans; Hydroxyindoleacetic Acid; Imipramine; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Serotonin; Structure-Activity Relationship; White People | 1984 |
Antidepressants and alpha 2-adrenergic autoreceptor desensitization.
Topics: Blood Pressure; Clonidine; Clorgyline; Drug Interactions; Female; Humans; Imipramine; Middle Aged; Propylamines; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment.
Topics: Adolescent; Adult; Aged; Amitriptyline; Blood Platelets; Clonidine; Depressive Disorder; Female; Humans; Hydrocortisone; Imipramine; Male; Middle Aged; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tritium | 1981 |
Attenuation by chronic imipramine treatment of [3H]clonidine binding to cortical membranes and of clonidine-induced hypothermia: the influence of central chemosympathectomy.
Topics: Animals; Body Temperature Regulation; Cerebral Cortex; Clonidine; Hydroxydopamines; Imipramine; Male; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic | 1982 |
Clinical response to clonidine and imipramine, and platelet alpha 2-adrenoreceptors in a case of agoraphobia with panic attacks.
Topics: Adult; Agoraphobia; Blood Platelets; Clonidine; Drug Therapy, Combination; Fear; Humans; Imipramine; Kinetics; Male; Panic; Phobic Disorders; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1982 |
Sensitivity in vivo of central alpha 2- and opiate receptors after chronic treatment with various antidepressants.
Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpromazine; Clomipramine; Clonidine; Desipramine; Evoked Potentials; Imipramine; Iprindole; Locus Coeruleus; Male; Mianserin; Morphine; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Zimeldine | 1982 |
Effects of chronic treatment with imipramine on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Clonidine; Cortical Synchronization; Electroencephalography; Imipramine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1982 |
Biological markers in obsessive-compulsive and affective disorders.
Topics: Blood Platelets; Clomipramine; Clonidine; Depressive Disorder; Dexamethasone; Electroencephalography; Growth Hormone; Humans; Hydrocortisone; Imipramine; Obsessive-Compulsive Disorder; Sleep | 1984 |
Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Depression; Disease Models, Animal; Electroencephalography; Electroshock; Humans; Imipramine; Male; Piperazines; Rats; Rats, Inbred Strains; Trazodone | 1983 |
Lactate provocation of panic attacks. I. Clinical and behavioral findings.
Topics: Adult; Agoraphobia; Anxiety Disorders; Clonidine; Desipramine; Fear; Female; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic | 1984 |
Hypertensive crisis induced by interaction of clonidine with imipramine.
Topics: Aged; Clonidine; Drug Interactions; Emergencies; Female; Humans; Hypertension; Imipramine; Time Factors | 1983 |
Serotonin-mimetic and antidepressant drugs on passive avoidance learning by olfactory bulbectomised rats.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Clonidine; Ergolines; Fenfluramine; Fluoxetine; Imipramine; Male; Metergoline; Mianserin; Olfactory Bulb; Quipazine; Rats; Serotonin; Serotonin Antagonists | 1980 |
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.
Topics: Albuterol; Animals; Clonidine; Desipramine; Drug Interactions; Exploratory Behavior; Fluoxetine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Yohimbine | 1982 |
The effect of single and chronic administration of imipramine on clonidine-induced hypothermia in the rat.
Topics: Animals; Body Temperature; Clonidine; Imipramine; Male; Rats; Time Factors | 1981 |
Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Bromouracil; Clonidine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Generalization, Stimulus; Imipramine; Male; Rats; Rats, Wistar | 1994 |
Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats.
Topics: Animals; Arousal; Brain; Citalopram; Clonidine; Dose-Response Relationship, Drug; Imipramine; Male; Norepinephrine; Nortriptyline; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, GABA; Reserpine; Serotonin; Yohimbine | 1994 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine | 1994 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Droxidopa; Drug Synergism; Idazoxan; Imipramine; Male; Methyltyrosines; Mice; Norepinephrine; Pargyline; Phentolamine; Physostigmine; Prazosin; Reserpine; Seizures; Serotonin | 1993 |
Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin.
Topics: Animals; Binding, Competitive; Blood Pressure; Brain Chemistry; Brain Stem; Cell Membrane; Cerebral Cortex; Clonidine; Heart Rate; Hypertension; Imipramine; Neurons; Paroxetine; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Serotonin; Serotonin | 1993 |
The discriminative stimulus effects of methamphetamine in pigeons.
Topics: Animals; Behavior, Animal; Clonidine; Cocaine; Columbidae; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dose-Response Relationship, Drug; Imipramine; Injections, Intramuscular; Male; Methamphetamine; Neurotransmitter Agents | 1995 |
In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
Topics: Adrenergic Uptake Inhibitors; Animals; Carrier Proteins; Cerebral Cortex; Citalopram; Clonidine; Desipramine; Fluoxetine; Fluvoxamine; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Raphe Nuclei; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters | 1996 |
Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem.
Topics: Affinity Labels; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Brain Stem; Clonidine; Down-Regulation; Imidazoline Receptors; Imipramine; Iodine Radioisotopes; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug | 1997 |
Some behavioural effects of antidepressant drugs are time-dependent.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Antidepressive Agents; Cell Membrane; Cerebral Cortex; Citalopram; Clonidine; Drug Administration Schedule; Exploratory Behavior; Imipramine; Male; Motor Activity; Propanolamines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-2; Receptors, Dopamine D2; Receptors, Dopamine D3; Synapses; Tetrahydronaphthalenes; Time Factors; Tritium | 2001 |
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Imipramine; Injections, Intraventricular; Male; Nociceptors; Pain; Pain Measurement; Prazosin; Rats; Rats, Wistar; Yohimbine | 2002 |
Adrenoceptor mechanisms underlying imipramine-induced memory deficits in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Imipramine; Male; Memory; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Yohimbine | 2003 |
Effects of imipramine on the expression and development of morphine dependence in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Dose-Response Relationship, Drug; Imipramine; Injections, Subcutaneous; Male; Mice; Morphine; Morphine Dependence; Motor Activity; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Yohimbine | 2003 |
The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Agonists; Aggression; Amantadine; Amphetamine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Clonidine; Drug Interactions; Drug Therapy, Combination; Exploratory Behavior; Hyperkinesis; Imipramine; Male; Motor Activity; Phenylephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 2004 |
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Imipramine; Macaca mulatta; Male; Methadyl Acetate; Muscle Rigidity; Naltrexone; Narcotic Antagonists; Respiratory Mechanics; Salivation; Substance Withdrawal Syndrome | 2005 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiazepoxide; Clonidine; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Imipramine; Interleukin-6; Maprotiline; Social Isolation; Stress, Psychological | 2009 |
Pharmacological reversal of cognitive bias in the chick anxiety-depression model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Bias; Chickens; Clonidine; Cognition Disorders; Cues; Depression; Disease Models, Animal; Imipramine; Stress, Psychological; Vocalization, Animal | 2012 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined Modality Therapy; Consciousness Disorders; Cyclohexanecarboxylic Acids; Diaper Rash; Drug Combinations; Drug Compounding; Drug Overdose; Emergencies; Gabapentin; gamma-Aminobutyric Acid; Humans; Imipramine; Infant; Intensive Care Units, Pediatric; Intubation, Intratracheal; Ketamine; Lidocaine; Male; Mefenamic Acid; Ointments; Reflex, Abnormal; Respiration Disorders; Skin Absorption | 2013 |
Toward Higher Sensitivity in Quantitative MALDI Imaging Mass Spectrometry of CNS Drugs Using a Nonpolar Matrix.
Topics: Animals; Brain Chemistry; Calibration; Central Nervous System Agents; Clonidine; Clozapine; Hydrophobic and Hydrophilic Interactions; Imipramine; Ketamine; Limit of Detection; Mice, Inbred C57BL; Nitriles; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xylazine | 2018 |