imipramine and chloroquine

imipramine has been researched along with chloroquine in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (32.50)	18.7374
1990's	2 (5.00)	18.2507
2000's	11 (27.50)	29.6817
2010's	14 (35.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Elshorst, B; Fiebig, K; Griesinger, C; Grimme, S; Jacobs, DM; Vogtherr, M; Zahn, R	1
Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, M; Smilkstein, MJ; Winter, R	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Drenckhahn, D; Lüllmann-Rauch, R	1
Kiryon, C; Miki, A; Nakayama, T; Ohsawa, K; Tanabe, K	1
Coudert, B; Dwyer, TM; Joshi, UM; Kodavanti, PR; Mehendale, HM	1
Gräbner, R; Meerbach, W; Müller, U; Zimmermann, W	1
Gräbner, R	1
Moccetti, T	1
Farbiszewski, R; Niewiarowski, S; Poplawski, A	1
Hadwiger, LA	1
Oldendorf, WH	1
Clèdes, J; Favarel-Garrigues, JC; Potaux, L; Sagardiluz, J	1
Gräbner, R; Meerbach, W	1
Andersson, A; Olsson, S; Tjälve, H	1
Lüllmann-Rauch, R	1
Ogunbona, FA; Onyeji, CO; Toriola, TA	1
Bhattacharjee, AK; Kyle, DE; Vennerstrom, JL	1
BESSON, H	1
Laggner, H; Neuhofer, A; Pagler, TA; Stangl, H; Strobl, W	1
de Faria, DL; Menezes, CM; Otelo, VA; Sant'Ana, AC	1

Reviews

2 review(s) available for imipramine and chloroquine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4 Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Perhexiline; Pigment Epithelium of Eye; Rats	1981

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.

Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4

Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Perhexiline; Pigment Epithelium of Eye; Rats

1981

Trials

1 trial(s) available for imipramine and chloroquine

Article	Year
Lack of pharmacokinetic interaction between chloroquine and imipramine. Therapeutic drug monitoring, 1993, Volume: 15, Issue:1 Topics: Administration, Oral; Adult; Chloroquine; Drug Interactions; Humans; Imipramine; Male	1993

Other Studies

37 other study(ies) available for imipramine and chloroquine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. Journal of medicinal chemistry, 2003, Aug-14, Volume: 46, Issue:17 Topics: Antimalarials; Binding Sites; Chloroquine; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Peptide Fragments; Phenothiazines; Prions; Protein Structure, Secondary; Quinacrine; Recombinant Proteins; Structure-Activity Relationship	2003
Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Acridones; Animals; Antimalarials; Cell Survival; Cells, Cultured; Drug Design; Drug Interactions; Drug Resistance, Multiple; Lymphocytes; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Molecular Structure; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship	2007
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4 Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Experimental myopathy induced by amphiphilic cationic compounds including several psychotropic drugs. Neuroscience, 1979, Volume: 4, Issue:4 Topics: Amitriptyline; Animals; Chloroquine; Chlorphentermine; Chlorpromazine; Female; Imipramine; Iprindole; Male; Microscopy, Electron; Muscles; Muscular Diseases; Phentermine; Piperazines; Psychotropic Drugs; Quinacrine; Rats; Triparanol	1979
Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites. Experimental parasitology, 1992, Volume: 74, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Chromatography, High Pressure Liquid; Desipramine; Drug Resistance; Erythrocytes; Female; Imipramine; Malaria; Mice; Mice, Inbred ICR; Plasmodium chabaudi; Trifluoperazine	1992
Types of interaction of amphiphilic drugs with phospholipid vesicles. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1 Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazine; Diphenylhexatriene; Imipramine; Lipidoses; Lung Diseases; Membrane Lipids; Phospholipids; Promethazine; Propranolol; Surface-Active Agents; Trimipramine	1988
Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats. Experimental pathology, 1987, Volume: 32, Issue:4 Topics: Animals; Chloroquine; Female; Fetal Organ Maturity; Gestational Age; Imipramine; Lung; Organ Size; Phospholipids; Pregnancy; Rats	1987
Influence of cationic amphiphilic drugs on the phosphatidylcholine hydrolysis by phospholipase A2. Biochemical pharmacology, 1987, Apr-01, Volume: 36, Issue:7 Topics: 1,2-Dipalmitoylphosphatidylcholine; Bee Venoms; Chloroquine; Chlorphentermine; Hydrolysis; Imipramine; Kinetics; Liposomes; Phentermine; Phospholipases; Phospholipases A; Phospholipases A2; Thermodynamics	1987
[Cardiotoxic drugs]. Schweizerische medizinische Wochenschrift, 1973, Apr-28, Volume: 103, Issue:17 Topics: Adult; Angina Pectoris; Anti-Bacterial Agents; Antipsychotic Agents; Chloroquine; Contraceptives, Oral; Death, Sudden; Electrocardiography; Emetine; Female; Heart Diseases; Humans; Imipramine; Middle Aged; Myocardial Infarction; Phenothiazines; Phenylbutazone	1973
[Effect of various drugs on platelet aggregation and liberation of platelet factor 4 (anti-heparin factor)]. Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4 Topics: Animals; Anticoagulants; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Chloroquine; Citrates; Fibrinogen; Fibrinolysis; Heparin Antagonists; Imipramine; Ouabain; Papaverine; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Rabbits; Sodium Salicylate	1969
Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs. Biochemical and biophysical research communications, 1972, Jan-14, Volume: 46, Issue:1 Topics: Antidepressive Agents; Antitussive Agents; Antiviral Agents; Chloroquine; Deamination; Ethylamines; Fluorenes; Histamine H1 Antagonists; Imipramine; Ketones; Lectins; Leucine; Lyases; Parasympatholytics; Phenothiazines; Phenylalanine; Piperidines; Plant Lectins; Plant Proteins; Plants, Edible; Propantheline; Quinacrine; Stimulation, Chemical; Tranquilizing Agents; Trimeprazine	1972
Brain uptake of metabolites and drugs following carotid arterial injections. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats	1971
[Cardiac complications in acute poisoning]. Journal de medecine de Bordeaux et du Sud-Ouest, 1967, Volume: 144, Issue:7 Topics: Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Child; Child, Preschool; Chloroquine; Digitalis Glycosides; Electrocardiography; Heart; Humans; Imipramine; Middle Aged; Poisoning; Quinine	1967
Imipramine and chloroquine induced alterations in phospholipid content of rat lung. Experimental pathology, 1983, Volume: 24, Issue:4 Topics: Animals; Chloroquine; Imipramine; Lung; Macrophages; Male; Phospholipids; Pulmonary Alveoli; Rats; Therapeutic Irrigation	1983
The uptake of 14C-chloroquine by mouse pancreatic islets in vitro. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:1 Topics: Absorption; Animals; Chloroquine; Chlorpromazine; Desipramine; Glucose; Hydrogen-Ion Concentration; Imipramine; Islets of Langerhans; Lidocaine; Mice; Nicotine; Nitrogen; Ouabain; Quinacrine; Temperature	1980
Structural analysis of chloroquine resistance reversal by imipramine analogs. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:9 Topics: Animals; Antimalarials; Chloroquine; Desipramine; Drug Interactions; Drug Resistance; Humans; Imipramine; Models, Molecular; Parasitic Sensitivity Tests; Plasmodium falciparum	2001
[THE HEART AND POISONINGS]. Maroc medical, 1964, Volume: 43 Topics: Chloroquine; Diagnosis; Digitalis Glycosides; Heart; Heart Failure; Imipramine; Prognosis; Quinidine; Quinine; Toxicology	1964
Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired. Journal of lipid research, 2007, Volume: 48, Issue:10 Topics: Androstenes; Animals; Biological Transport; Carrier Proteins; Chloroquine; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Endocytosis; Fibroblasts; Humans; Imipramine; Intracellular Signaling Peptides and Proteins; Lipoproteins, HDL; Lysosomes; Membrane Glycoproteins; Monensin; Niemann-Pick C1 Protein; Scavenger Receptors, Class B	2007
Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ). Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 Topics: Aminoquinolines; Antimalarials; Chloroquine; Dibenzazepines; Hemin; Hydrogen-Ion Concentration; Imipramine; Molecular Dynamics Simulation; Plasmodium falciparum; Spectrophotometry, Ultraviolet	2011