imipramine has been researched along with aspirin in 53 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (45.28) | 18.7374 |
1990's | 3 (5.66) | 18.2507 |
2000's | 12 (22.64) | 29.6817 |
2010's | 14 (26.42) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Gubernator, K; Kansy, M; Senner, F | 1 |
Strassburg, CP; Tukey, RH | 1 |
Duffy, EM; Jorgensen, WL | 1 |
Topliss, JG; Yoshida, F | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
Grant, RA; Zucker, MB | 1 |
Byczkowski, JZ; Hać, EE | 1 |
de Gaetano, G; Garattini, S; Miragliotta, G; Roncaglioni, MC; Wielosz, M | 1 |
Good, MI | 1 |
Gastmeier, K; Hass, M; Kuteifan, K; Schott, H | 1 |
Bianchine, JR; Gerber, MC; Gerber, N; Tejwani, GA | 1 |
Benedict, CR; Hussain, MN | 1 |
Hart, FD; Huskisson, EC | 1 |
Bolan, JC; Glenn, CH; Hardison, MD; Mason, RG; Mohammad, SF; Morton, BD | 1 |
Evreux, JC; Faucon, G | 1 |
Oldendorf, WH | 1 |
Wilson, JG | 1 |
Spilker, BA; van Balken, H | 1 |
Cazenave, JP; Guccione, MA; Mustard, JF; Packham, MA | 1 |
Trautmann, A | 1 |
Bounameaux, Y | 1 |
Begent, NA; Born, GV | 1 |
Bhalla, TN; Bhargava, KP; Kohli, RP; Sinha, JN | 1 |
Rohte, O | 2 |
Kreppel, E | 1 |
Hall, NA | 1 |
Kvarstein, B; Stormorken, H | 1 |
Ibrahim, I; Sulman, FG; Weller, CP | 1 |
Charpentier, J | 1 |
Bergeron, JA; DiNovo, JM; Dodds, WJ | 1 |
Flores-Pérez, J; Juárez-Olguín, H; Jung-Cook, H; Lares-Asseff, I | 1 |
Chen, L; Guan, XT; Shao, F; Wang, W; Xie, X | 1 |
Borek-Dohalska, L; Fojtikova, V; Martinkova, M; Mináriková, M; Sedláček, J; Šikut, M; Stiborová, M; Vyskočilová, E | 1 |
4 review(s) available for imipramine and aspirin
Article | Year |
---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug interactions with cimetidine: an update.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anticoagulants; Anticonvulsants; Aspirin; Aziridines; Benzodiazepines; Benzoquinones; Cimetidine; Drug Interactions; Humans; Ibuprofen; Imipramine; Kinetics; Lidocaine; Liver Circulation; Pituitary Gland; Procaine; Xanthines | 1985 |
Present status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics; Antitubercular Agents; Appetite Depressants; Aspirin; Cortisone; Drug-Related Side Effects and Adverse Reactions; Embryonic and Fetal Development; Female; Fetal Diseases; Folic Acid Antagonists; Humans; Hypoglycemic Agents; Imipramine; Lysergic Acid Diethylamide; Meclizine; Pregnancy; Steroids; Sulfonamides; Thalidomide; Tranquilizing Agents | 1973 |
49 other study(ies) available for imipramine and aspirin
Article | Year |
---|---|
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Altered uptake and release of 14C-serotonin in platelets following incubation of platelet-rich plasma with EDTA.
Topics: Aspirin; Blood Platelets; Connective Tissue; Dose-Response Relationship, Drug; Edetic Acid; Humans; Imipramine; Serotonin; Time Factors | 1979 |
Relationship between inhibition of prostaglandin beta-oxidation and deenergization of mitochondrial membranes.
Topics: Animals; Aspirin; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorpromazine; Dinitrophenols; Imipramine; Indomethacin; Mitochondria, Liver; Mitochondrial Swelling; Oxidation-Reduction; Oxidative Phosphorylation; Prostaglandins E; Rats; Salicylates | 1978 |
In vitro effect of suloctidil on 14C-5-hydroxytryptamine uptake and liberation in rat platelets.
Topics: Animals; Aspirin; Blood Platelets; Clomipramine; Dextroamphetamine; Fenfluramine; Imipramine; Kinetics; L-Lactate Dehydrogenase; Male; p-Chloroamphetamine; Propanolamines; Rats; Serotonin; Temperature | 1977 |
Organic dissociative syndrome associated with antimigraine pharmacotherapy.
Topics: Adolescent; Analgesics; Aspirin; Barbiturates; Caffeine; Dissociative Disorders; Drug Combinations; Drug Therapy, Combination; Female; Humans; Imipramine; Migraine Disorders; Phenacetin; Substance-Related Disorders | 1991 |
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results].
Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Indomethacin; Meperidine; Morphine; Pain; Pain Measurement; Prospective Studies; Urologic Neoplasms | 1990 |
Radioenzymatic microassay for picogram quantities of serotonin or acetylserotonin in biological fluids and tissues.
Topics: Acetylserotonin O-Methyltransferase; Aspirin; Brain Chemistry; Erythrocytes; Humans; Imipramine; Microchemistry; Pineal Gland; Radioisotope Dilution Technique; Serotonin; Tritium | 1987 |
Pain patterns in the rheumatic disorders.
Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Depression; Giant Cell Arteritis; Gout; Humans; Hypochondriasis; Imipramine; Intervertebral Disc Displacement; Osteoarthritis; Pain; Pain Insensitivity, Congenital; Spondylitis, Ankylosing | 1972 |
Adhesion of human blood platelets to glass and polymer surfaces. I. Studies with platelets in plasma.
Topics: Adult; Age Factors; Amitriptyline; Aspirin; Blood Coagulation Disorders; Chloromercuribenzoates; Chlorpromazine; Citrates; Desipramine; Edetic Acid; Glass; Glucosamine; Heparin; Humans; Imipramine; Middle Aged; Platelet Adhesiveness; Polyethylenes; Polymers; Polytetrafluoroethylene; Polyvinyl Chloride; Promethazine; Sulfinpyrazone | 1974 |
[Experimentation in toxicology].
Topics: Animals; Aspirin; Barbiturates; Central Nervous System Stimulants; Drug Synergism; Imipramine; Poisoning; Salicylates | 1967 |
Brain uptake of metabolites and drugs following carotid arterial injections.
Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats | 1971 |
Formation and embolization of thrombi after electrical stimulation. On the method and evaluation of drugs.
Topics: Animals; Aspirin; Cats; Cranial Sinuses; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electric Stimulation; Female; Guinea Pigs; Heparin; Imipramine; Male; Mesenteric Arteries; Mesenteric Veins; Methods; Mice; Papaverine; Phenoxybenzamine; Platelet Adhesiveness; Rabbits; Rats; Streptokinase; Thromboembolism; Time Factors | 1973 |
Inhibition of platelet adherence to a collagen-coated surface by nonsteroidal anti-inflammatory drugs, pyrimido-pyrimidine and tricyclic compounds, and lidocaine.
Topics: Antidepressive Agents; Aspirin; Carbon Radioisotopes; Chromium Radioisotopes; Collagen; Imipramine; Lidocaine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Pyrimidines; Serotonin | 1974 |
[Dialysis of drugs and poisons. 2].
Topics: Acetaminophen; Aminopyrine; Amitriptyline; Aspirin; Carbamazepine; Chlordiazepoxide; Chlorpromazine; Dextropropoxyphene; Diazepam; Heroin; Humans; Imipramine; Lithium; Pargyline; Pentazocine; Phenacetin; Phenelzine; Phenytoin; Poisoning; Primidone; Promazine; Renal Dialysis; Salicylates; Tranylcypromine; Trifluoperazine | 1972 |
[Pharmacodynamic prevention of thrombosis].
Topics: Adenosine Diphosphate; Amitriptyline; Anticoagulants; Aspirin; Collagen; Dipyridamole; Guanethidine; Humans; Imipramine; Papaverine; Thrombin; Thrombosis | 1971 |
Comparison of the effects of drugs on the aggregation of hamster platelets in vivo and in vitro.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aspirin; Blood Volume; Carbon Isotopes; Cheek; Cricetinae; Desipramine; Imipramine; In Vitro Techniques; Iontophoresis; Microcirculation; Platelet Adhesiveness; Sodium Salicylate; Tritium | 1971 |
Aconitine-induced writhing: a method for assessment of analgesic activity.
Topics: Aconitum; Analgesics; Animals; Aspirin; Behavior, Animal; Chlorpromazine; Imipramine; Mephenesin; Methaqualone; Methods; Mice; Morphine; Phenoxybenzamine; Phenylbutazone; Phenytoin; Sodium Salicylate | 1969 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Female; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Psychopharmacology | 1969 |
[Principles and risks of drug treatment of pain].
Topics: Aminopyrine; Analgesics; Antidepressive Agents; Antipyrine; Aspirin; Codeine; Dibenzazepines; Humans; Imipramine; Levallorphan; Levorphanol; Methadone; Morphine; Pain; Phenacetin; Phenylbutazone; Pyrazoles; Salicylamides; Salicylates; Sulfonic Acids | 1969 |
The other edge.
Topics: Aged; Aspirin; Atropine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Imipramine; Triiodothyronine | 1970 |
Influence of acetylsalicylic acid, butazolidine, colchicine, hydrocortisone, chlorpromazine and imipramine on the phagocytosis of polystyrene latex particles by human leucocytes.
Topics: Aspirin; Chlorpromazine; Colchicine; Humans; Hydrocortisone; Imipramine; In Vitro Techniques; Latex; Leukocytes; Microspheres; Oxygen Consumption; Phagocytosis; Phenylbutazone; Polystyrenes | 1971 |
Studies of the influence of some psychotropic substances on the grooming behaviour of white mice.
Topics: Amitriptyline; Animals; Aspirin; Charcoal; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Grooming; Haloperidol; Imipramine; Iproniazid; Metronidazole; Mice; Nortriptyline; Sodium Chloride; Solvents; Tranquilizing Agents | 1968 |
Analgesic profile of tranquillizers in multiple screening tests in mice.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Chlorpromazine; Codeine; Diazepam; Diphenhydramine; Electric Stimulation; Haloperidol; Hot Temperature; Hydroxyzine; Imipramine; Isocarboxazid; Male; Meprobamate; Mice; Morphine; Perphenazine; Phenobarbital; Phenothiazines; Promazine; Promethazine; Reserpine; Tetrabenazine; Thiopental; Time Factors; Tranquilizing Agents | 1968 |
[Recent studies on the action mechanism of some central nervous system analgesics. Acetylsalicylic acid, imipramine, iminostilbene].
Topics: Amphetamine; Animals; Aspirin; Atropine; Behavior, Animal; Central Nervous System; Dibenzylchlorethamine; Drug Antagonism; Drug Synergism; Electroshock; Imipramine; Injections, Intraperitoneal; Male; Pain; Physostigmine; Rats; Stilbenes | 1966 |
A native whole blood assay for blood-materials interaction.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Physiological Phenomena; Blood Platelets; Citrates; Collagen; Imipramine; Methods; Rabbits; Science | 1981 |
Adverse effects of imipramine are increased by interaction with ASA in depressed patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Aspirin; Depressive Disorder; Drug Interactions; Female; Humans; Imipramine; Male | 2000 |
Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine.
Topics: Animals; Antidepressive Agents; Aspirin; Behavior, Animal; Corticosterone; Endocrine Glands; Fluoxetine; Imipramine; Immune System; Interleukin-6; Male; Rats; Rats, Sprague-Dawley; Swimming; Tumor Necrosis Factor-alpha | 2014 |
The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study.
Topics: Adsorption; Alpha-Amanitin; Amlodipine; Antidotes; Aspirin; Carbamazepine; Charcoal; Digoxin; Ibuprofen; Imipramine; Oxazepam; Phenobarbital; Poisoning; Promethazine; Silicates; Theophylline | 2017 |