imipramine has been researched along with 2-hydroxyimipramine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (39.29) | 18.7374 |
| 1990's | 14 (50.00) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Perel, JM; Pollock, BG | 1 |
| Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR | 1 |
| Foglia, JP; Perel, JM; Sorisio, D | 1 |
| Brøsen, K; Meyer, UA; Zeugin, T | 1 |
| Cooper, T; Dell, RB; Hein, K; Puig-Antich, J; Ramakrishnan, R | 1 |
| Chiba, M; Fujita, S; Suzuki, T | 1 |
| Barnhill, JG; Ciraulo, AM; Ciraulo, DA; Jaffe, JH; Tarmey, MF | 1 |
| Bupp, SJ; Preskorn, SH; Weller, EB; Weller, RA | 1 |
| Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV | 1 |
| Fraser, AD; Isner, AF; Susnik, E | 1 |
| Bech, P; Brøsen, K; Gram, LF; Klysner, R | 1 |
| Brøsen, K; Gram, LF; Otton, SV | 1 |
| DeVane, CL; Jusko, WJ; Sutfin, TA | 1 |
| DeVane, CL; Stout, SA | 1 |
| DeVane, CL; Simpkins, JW; Stout, SA | 1 |
| Barkai, AI; Cooper, TB; Suckow, RF | 1 |
| Bjerre, M; Gram, LF; Kragh-Sørensen, P; Kvinesdal, B; Molin, J; Pedersen, OL; Reisby, N | 1 |
| Calil, HM; Goodwin, FK; Jusko, WJ; Potter, WZ; Rapoport, J; Sutfin, TA; Zavadil, AP | 1 |
| Brøsen, K; Madsen, H; Nielsen, KK | 1 |
| Chiba, K; Hayashi, M; Ishizaki, T; Koyama, E; Saitoh, A; Tani, M | 1 |
| Baker, GB; Coutts, RT; Daneshtalab, M; Su, P | 2 |
| Sequeira, DJ; Strobel, HW | 1 |
| Chan, K; Chen, AG; Chen, CN; Chiu, H; Lee, S; Wing, YK | 1 |
| Chiba, K; Ishizaki, T; Kawakatsu, S; Koyama, E; Kubota, T; Morinobu, S; Tanaka, T; Totsuka, S | 1 |
| Linnet, K | 1 |
3 trial(s) available for imipramine and 2-hydroxyimipramine
| Article | Year |
|---|---|
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil | 1992 |
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.
Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine | 1986 |
The analysis and disposition of imipramine and its active metabolites in man.
Topics: Administration, Oral; Biotransformation; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Injections, Intramuscular; Kinetics; Male | 1984 |
25 other study(ies) available for imipramine and 2-hydroxyimipramine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine.
Topics: Animals; Arrhythmias, Cardiac; Blood Proteins; Cardiac Output; Electrocardiography; Half-Life; Heart Diseases; Hemodynamics; Imipramine; Swine | 1992 |
Determination of imipramine, desipramine and their hydroxy metabolites by reversed-phase chromatography with ultraviolet and coulometric detection.
Topics: Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Humans; Imipramine; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine.
Topics: Antibodies; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; DNA; Humans; Imipramine; Isoenzymes; Kidney; Kinetics; Methotrimeprazine; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Sparteine; Transfection | 1991 |
Model for the kinetics of imipramine and its metabolites in adolescents.
Topics: Adolescent; Desipramine; Female; Humans; Imipramine; Male; Models, Biological; Models, Theoretical | 1990 |
Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Imipramine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1990 |
Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls.
Topics: Adult; Alcoholism; Electrocardiography; Humans; Imipramine; Infusions, Intravenous; Male; Middle Aged; Reference Values | 1990 |
Plasma levels of imipramine and metabolites in 68 hospitalized children.
Topics: Adolescent; Child; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Psychiatric Department, Hospital | 1989 |
Analysis of 2-hydroxyimipramine in an imipramine-related fatality.
Topics: Acetaminophen; Adult; Alcoholic Intoxication; Antidepressive Agents, Tricyclic; Desipramine; Female; Humans; Imipramine | 1987 |
Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics.
Topics: Adult; Aged; Biotransformation; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged; Phenotype; Time Factors | 1986 |
Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype.
Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Methylation; Oxidation-Reduction; Phenotype; Sparteine | 1986 |
Quantification of imipramine and its major metabolites in whole blood, brain, and other tissues of the rat by liquid chromatography.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Female; Fetus; Imipramine; Pregnancy; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat.
Topics: Animals; Brain; Desipramine; Erythrocytes; Female; Imipramine; Kinetics; Male; Pregnancy; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo.
Topics: Animals; Brain; Desipramine; Dopamine; Imipramine; Injections, Intraventricular; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution | 1984 |
Imipramine metabolites in blood of patients during therapy and after overdose.
Topics: Adult; Aged; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged | 1983 |
Active metabolites of imipramine and desipramine in man.
Topics: Adolescent; Adult; Aged; Biotransformation; Child; Desipramine; Double-Blind Method; Enuresis; Female; Humans; Imipramine; Male; Middle Aged | 1982 |
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.
Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Denmark; Desipramine; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Sparteine | 1995 |
The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Desipramine; Humans; Hydroxylation; Imipramine; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases | 1994 |
Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line.
Topics: Catalysis; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Humans; Imipramine; Isoenzymes; Methylation; Mixed Function Oxygenases; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity | 1993 |
Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability.
Topics: Acetylation; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Gas Chromatography-Mass Spectrometry; Humans; Imipramine; Isoenzymes; Mixed Function Oxygenases | 1993 |
High-performance liquid chromatographic method for the analysis of imipramine metabolism in vitro by liver and brain microsomes.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Desipramine; Hydroxylation; Imipramine; Male; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1995 |
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Sensitivity and Specificity | 1997 |
Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy.
Topics: Adult; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Depressive Disorder, Major; DNA Mutational Analysis; Dose-Response Relationship, Drug; Exons; Female; Genetic Carrier Screening; Genotype; Humans; Imipramine; Male; Middle Aged; Mixed Function Oxygenases; Polymorphism, Genetic; Treatment Outcome | 1997 |
In vitro microsomal metabolism of imipramine under conditions mimicking the in vivo steady-state situation.
Topics: Cytochrome P-450 Enzyme System; Desipramine; Hydroxylation; Imipramine; Microsomes, Liver; Models, Biological | 2004 |