Compounds > imipramine

imipramine and 2-hydroxydesipramine

imipramine has been researched along with 2-hydroxydesipramine in 18 studies

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (55.56)	18.7374
1990's	8 (44.44)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR	1
Foglia, JP; Perel, JM; Sorisio, D	1
Brøsen, K; Gram, LF; Kragh-Sørensen, P	1
Cooper, T; Dell, RB; Hein, K; Puig-Antich, J; Ramakrishnan, R	1
Chiba, M; Fujita, S; Suzuki, T	1
Bupp, SJ; Preskorn, SH; Weller, EB; Weller, RA	1
Brøsen, K; Gram, LF	1
Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV	1
Arena, A; Pisani, F; Spina, E	1
Bech, P; Brøsen, K; Gram, LF; Klysner, R	1
Brøsen, K; Gram, LF; Otton, SV	1
DeVane, CL; Jusko, WJ; Sutfin, TA	1
Barkai, AI; Cooper, TB; Suckow, RF	1
Bjerre, M; Gram, LF; Kragh-Sørensen, P; Kvinesdal, B; Molin, J; Pedersen, OL; Reisby, N	1
Calil, HM; Goodwin, FK; Jusko, WJ; Potter, WZ; Rapoport, J; Sutfin, TA; Zavadil, AP	1
Brøsen, K; Madsen, H; Nielsen, KK	1
Baker, GB; Coutts, RT; Daneshtalab, M; Su, P	1
Chan, K; Chen, AG; Chen, CN; Chiu, H; Lee, S; Wing, YK	1

Trials

3 trial(s) available for imipramine and 2-hydroxydesipramine

Article	Year
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine. Journal of clinical pharmacology, 1992, Volume: 32, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil	1992
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. European journal of clinical pharmacology, 1986, Volume: 30, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine	1986
The analysis and disposition of imipramine and its active metabolites in man. Psychopharmacology, 1984, Volume: 82, Issue:4 Topics: Administration, Oral; Biotransformation; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Injections, Intramuscular; Kinetics; Male	1984

Other Studies

15 other study(ies) available for imipramine and 2-hydroxydesipramine

Article	Year
Determination of imipramine, desipramine and their hydroxy metabolites by reversed-phase chromatography with ultraviolet and coulometric detection. Journal of chromatography, 1991, Dec-06, Volume: 572, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Humans; Imipramine; Reproducibility of Results; Spectrophotometry, Ultraviolet	1991
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin. Therapeutic drug monitoring, 1991, Volume: 13, Issue:2 Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine	1991
Model for the kinetics of imipramine and its metabolites in adolescents. Therapeutic drug monitoring, 1990, Volume: 12, Issue:5 Topics: Adolescent; Desipramine; Female; Humans; Imipramine; Male; Models, Biological; Models, Theoretical	1990
Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes. Biochemical pharmacology, 1990, Jan-15, Volume: 39, Issue:2 Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Imipramine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains	1990
Plasma levels of imipramine and metabolites in 68 hospitalized children. Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:3 Topics: Adolescent; Child; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Psychiatric Department, Hospital	1989
Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine. European journal of clinical pharmacology, 1989, Volume: 37, Issue:2 Topics: Adult; Dealkylation; Desipramine; Drug Interactions; Female; Half-Life; Humans; Hydroxylation; Imipramine; Male; Phenotype; Quinidine; Sparteine	1989
Urinary desipramine hydroxylation index and steady-state plasma concentrations of imipramine and desipramine. Therapeutic drug monitoring, 1987, Volume: 9, Issue:2 Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged	1987
Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics. European journal of clinical pharmacology, 1986, Volume: 30, Issue:1 Topics: Adult; Aged; Biotransformation; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged; Phenotype; Time Factors	1986
Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:5 Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Methylation; Oxidation-Reduction; Phenotype; Sparteine	1986
Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:2 Topics: Animals; Brain; Desipramine; Dopamine; Imipramine; Injections, Intraventricular; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution	1984
Imipramine metabolites in blood of patients during therapy and after overdose. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:3 Topics: Adult; Aged; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged	1983
Active metabolites of imipramine and desipramine in man. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Adolescent; Adult; Aged; Biotransformation; Child; Desipramine; Double-Blind Method; Enuresis; Female; Humans; Imipramine; Male; Middle Aged	1982
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study. British journal of clinical pharmacology, 1995, Volume: 39, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Denmark; Desipramine; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Sparteine	1995
Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:11 Topics: Catalysis; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Humans; Imipramine; Isoenzymes; Methylation; Mixed Function Oxygenases; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity	1993
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1997, May-23, Volume: 693, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Sensitivity and Specificity	1997