iminoquinone and methoxyamine

iminoquinone has been researched along with methoxyamine* in 1 studies

Other Studies

1 other study(ies) available for iminoquinone and methoxyamine

Article	Year
Investigation of Fenebrutinib Metabolism and Bioactivation Using MS Molecules (Basel, Switzerland), 2023, May-22, Volume: 28, Issue:10 Fenebrutinib is an orally available Bruton tyrosine kinase inhibitor. It is currently in multiple phase III clinical trials for the management of B-cell tumors and autoimmune disorders. Elementary in-silico studies were first performed to predict susceptible sites of metabolism and structural alerts for toxicities by StarDrop WhichP450™ module and DEREK software; respectively. Fenebrutinib metabolites and adducts were characterized in-vitro in rat liver microsomes (RLM) using MS3 method in Ion Trap LC-MS/MS. Formation of reactive and unstable intermediates was explored using potassium cyanide (KCN), glutathione (GSH) and methoxylamine as trapping nucleophiles to capture the transient and unstable iminium, 6-iminopyridin-3( Topics: Aldehydes; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyanides; Glutathione; Microsomes, Liver; Piperazines; Pyridones; Rats; Tandem Mass Spectrometry	2023

Article

Year

Investigation of Fenebrutinib Metabolism and Bioactivation Using MS

Molecules (Basel, Switzerland), 2023, May-22, Volume: 28, Issue:10

Fenebrutinib is an orally available Bruton tyrosine kinase inhibitor. It is currently in multiple phase III clinical trials for the management of B-cell tumors and autoimmune disorders. Elementary in-silico studies were first performed to predict susceptible sites of metabolism and structural alerts for toxicities by StarDrop WhichP450™ module and DEREK software; respectively. Fenebrutinib metabolites and adducts were characterized in-vitro in rat liver microsomes (RLM) using MS3 method in Ion Trap LC-MS/MS. Formation of reactive and unstable intermediates was explored using potassium cyanide (KCN), glutathione (GSH) and methoxylamine as trapping nucleophiles to capture the transient and unstable iminium, 6-iminopyridin-3(

Topics: Aldehydes; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyanides; Glutathione; Microsomes, Liver; Piperazines; Pyridones; Rats; Tandem Mass Spectrometry

2023