Page last updated: 2024-09-04

imiloxan and yohimbine

imiloxan has been researched along with yohimbine in 14 studies

Compound Research Comparison

Studies
(imiloxan)
Trials
(imiloxan)
Recent Studies (post-2010)
(imiloxan)
Studies
(yohimbine)
Trials
(yohimbine)
Recent Studies (post-2010) (yohimbine)
450215,893253532

Protein Interaction Comparison

ProteinTaxonomyimiloxan (IC50)yohimbine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.0353
Cytochrome P450 2D6Homo sapiens (human)1.02
D(2) dopamine receptorHomo sapiens (human)2.06
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-2B adrenergic receptorHomo sapiens (human)0.0428
Alpha-2C adrenergic receptorHomo sapiens (human)0.0466
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.126
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-1D adrenergic receptorHomo sapiens (human)1.013
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.126
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.074
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.3
5-hydroxytryptamine receptor 6Homo sapiens (human)1.689

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's1 (7.14)18.2507
2000's5 (35.71)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Butler, RC; Chapleo, CB; Doxey, JC; Myers, PL; Roach, AG; Smith, CF1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Flavahan, NA; Grant, TL; Greig, J; McGrath, JC; McKean, CE; Reid, JL1
Davidson, JM; Kwong, LL; Peroutka, SJ; Smith, ER1
Davidson, JM; Lee, RL; Schnur, SL; Smith, ER2
Chou, B; Green, PG; Khasar, SG; Levine, JD1
Arulmani, U; Centurión, D; Saxena, PR; Valdivia, LF; Villalón, CM1
Lodge, NJ; Myers, RA; Plym, MJ; Signor, LJ1
Hernádi, I; Kovács, P1
Albarrán-Juárez, JA; Centurión, D; Görnemann, T; Lozano-Cuenca, J; Pertz, HH; Villalón, CM1
de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR1
Dukat, M; Scheinin, M; Vainio, M; Young, S1
Hernádi, I; Tóth, M; Uzsoki, B1

Other Studies

14 other study(ies) available for imiloxan and yohimbine

ArticleYear
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Dioxins; Dose-Response Relationship, Drug; Idazoxan; Male; Mice; Phenylephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synapses; Vas Deferens

1983
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Attempts to uncover subtypes of alpha-adrenoceptors and associated mechanisms by using sequential administration of blocking drugs.
    Clinical science (London, England : 1979), 1985, Volume: 68 Suppl 10

    Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Propranolol; Rabbits; Rats; Receptors, Adrenergic, alpha; Synaptic Transmission; Yohimbine

1985
Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors.
    Behavioral neuroscience, 1986, Volume: 100, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Brain; Dioxanes; Ejaculation; Idazoxan; Imidazoles; Indans; Male; Methoxydimethyltryptamines; Rats; Receptors, Adrenergic, alpha; Receptors, Serotonin; Stimulation, Chemical; Tetrahydronaphthalenes; Yohimbine

1986
Alpha 2-adrenoceptor antagonists and male sexual behavior: II. Erectile and ejaculatory reflexes.
    Physiology & behavior, 1987, Volume: 41, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Ejaculation; Idazoxan; Imidazoles; Male; Penile Erection; Rats; Reflex; Sexual Behavior, Animal; Yohimbine

1987
Alpha 2-adrenoceptor antagonists and male sexual behavior: I. Mating behavior.
    Physiology & behavior, 1987, Volume: 41, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Male; Rats; Sexual Behavior, Animal; Yohimbine

1987
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
    Neuroscience, 1995, Volume: 66, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcimycin; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Pain Measurement; Peripheral Nervous System; Quinoxalines; Rats; Rats, Sprague-Dawley; Yohimbine

1995
5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:1

    Topics: Animals; Biphenyl Compounds; Blood Pressure; Carotid Artery, External; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Ergotamine; Hypotension; Imidazoles; Indoles; Injections, Intravenous; Isoindoles; Male; Piperazines; Piperidones; Prazosin; Quinolizines; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha; Regional Blood Flow; Spiro Compounds; Sympathectomy; Vagotomy; Vasoconstriction; Yohimbine

2004
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
    Neurourology and urodynamics, 2004, Volume: 23, Issue:7

    Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; ATP-Binding Cassette Transporters; Benzhydryl Compounds; Buspirone; Cresols; Cromakalim; Dose-Response Relationship, Drug; Female; Imidazoles; Indoles; Isoindoles; KATP Channels; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phenylpropanolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolterodine Tartrate; Urinary Bladder; Urodynamics; Yohimbine

2004
Yohimbine acts as a putative in vivo alpha2A/D-antagonist in the rat prefrontal cortex.
    Neuroscience letters, 2006, Jul-24, Volume: 402, Issue:3

    Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Animals; Drug Antagonism; Guanfacine; Imidazoles; Indoles; Iontophoresis; Isoindoles; Male; Prefrontal Cortex; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Yohimbine

2006
Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.
    British journal of pharmacology, 2008, Volume: 154, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Imidazoles; In Vitro Techniques; Isoindoles; Male; Neurons, Afferent; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine

2008
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine

2009
Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Clonidine; Drug Synergism; Guanidines; Imidazoles; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Receptors, Adrenergic, alpha; Tail; Yohimbine

2010
Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety.
    Neuroscience letters, 2011, Jul-25, Volume: 499, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Guanfacine; Imidazoles; Individuality; Isoindoles; Male; Maze Learning; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine

2011