Page last updated: 2024-09-04

imiloxan and clonidine

imiloxan has been researched along with clonidine in 6 studies

Compound Research Comparison

Studies
(imiloxan)
Trials
(imiloxan)
Recent Studies (post-2010)
(imiloxan)
Studies
(clonidine)
Trials
(clonidine)
Recent Studies (post-2010) (clonidine)
4502113,6922,0441,394

Protein Interaction Comparison

ProteinTaxonomyimiloxan (IC50)clonidine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.101
Alpha-2B adrenergic receptorHomo sapiens (human)0.0353
Alpha-2C adrenergic receptorHomo sapiens (human)0.0115
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)5.365
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0173
Alpha-1D adrenergic receptorHomo sapiens (human)1.21
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)5.365
Alpha-2A adrenergic receptorBos taurus (cattle)0.002
NischarinRattus norvegicus (Norway rat)0.3662

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Butler, RC; Chapleo, CB; Doxey, JC; Myers, PL; Roach, AG; Smith, CF1
Takano, M; Takano, Y; Yaksh, TL1
Chou, B; Green, PG; Khasar, SG; Levine, JD1
Albarrán-Juárez, JA; Centurión, D; Görnemann, T; Lozano-Cuenca, J; Pertz, HH; Villalón, CM1
Dukat, M; Scheinin, M; Vainio, M; Young, S1
Endo, S; Kozawa, M; Murakami, H; Muto, M; Tadano, T; Tan-No, K; Tsuchiya, M; Yaoita, F1

Other Studies

6 other study(ies) available for imiloxan and clonidine

ArticleYear
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:6

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Dioxins; Dose-Response Relationship, Drug; Idazoxan; Male; Mice; Phenylephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synapses; Vas Deferens

1983
The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord.
    European journal of pharmacology, 1992, Sep-04, Volume: 219, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; Injections, Spinal; Male; Medetomidine; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord

1992
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
    Neuroscience, 1995, Volume: 66, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcimycin; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Pain Measurement; Peripheral Nervous System; Quinoxalines; Rats; Rats, Sprague-Dawley; Yohimbine

1995
Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.
    British journal of pharmacology, 2008, Volume: 154, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Imidazoles; In Vitro Techniques; Isoindoles; Male; Neurons, Afferent; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine

2008
Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Clonidine; Drug Synergism; Guanidines; Imidazoles; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Receptors, Adrenergic, alpha; Tail; Yohimbine

2010
Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep.
    Physiology & behavior, 2018, 03-15, Volume: 186

    Topics: Acetic Acid; Acridines; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; Imidazoles; Irritable Bowel Syndrome; Isoindoles; Male; Mice; Piperazines; Receptors, Adrenergic; Sleep Deprivation; Sleep, REM; Visceral Pain

2018