imidocarb-dipropionate has been researched along with diminazene-aceturate* in 6 studies
6 other study(ies) available for imidocarb-dipropionate and diminazene-aceturate
Article | Year |
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Diminazene aceturate and imidocarb dipropionate-based combination therapy for babesiosis - A new paradigm.
Topics: Animals; Babesia; Babesiosis; Imidocarb; Mice; Theileria | 2023 |
Compounds from the Medicines for Malaria Venture Box Inhibit In Vitro Growth of
Babesiosis is an infectious disease with an empty drug pipeline. A search inside chemical libraries for novel potent antibabesial candidates may help fill such an empty drug pipeline. A total of 400 compounds (200 drug-like and 200 probe-like) from the Malaria Box were evaluated in the current study against the in vitro growth of Topics: Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Blood-Borne Pathogens; Diminazene; Humans; Imidocarb; Malaria; Plants, Medicinal | 2021 |
Administration of diminazene aceturate or imidocarb dipropionate for treatment of cytauxzoonosis in cats.
Bobcats (Lynx rufus) are the reservoir hosts for Cytauxzoon felis, the causative agent of cytauxzoonosis. Cytauxzoonosis is a highly fatal tickborne blood protozoal disease of domestic and exotic cats. Treatment of clinically affected cats has generally been unrewarding. In our report, 6 of 7 cats had signs of illness and laboratory findings indicative of cytauxzoonosis and were successfully treated with 2 i.m. injections of diminazene aceturate or imidocarb dipropionate (2 mg/kg [0.9 mg/lb] of body weight, each). One cat died after the first injection of diminazene. Additional treatment with isotonic fluids i.v. and heparin s.c. were used as supportive care for dehydration and disseminated intravascular coagulation that were detected by laboratory testing between diminazene or imidocarb treatments. Atropine was effective in recovery and preventing adverse reactions associated with imidocarb treatment of 1 cat. Topics: Animals; Antiprotozoal Agents; Blood; Blood Transfusion; Body Temperature; Cat Diseases; Cats; Diminazene; Erythrocyte Count; Hematocrit; Hematologic Diseases; Heparin; Imidocarb; Injections, Intramuscular; Isotonic Solutions; Leukocyte Count; Male; Piroplasmida; Protozoan Infections; Protozoan Infections, Animal; Urinalysis | 1999 |
Studies on the comprehensive control of babesiasis in cattle and buffaloes.
To obtain a highly effective method for controlling babesiosis in cattle and buffalo, an epidemiological survey was carried out at Zuiyun village in Hubai Province. On the grounds of the epidemiological data, control measures which included preventive drugs and killing the vectors were devised. After two years of control no clinical cases of bovine babesiosis were found. The average number of ticks on cattle or buffalo decreased from 9-282 to 0-11.3. Good results were obtained in another epidemic area using this control method. These results indicated that this technique of controlling babesiosis is highly effective. Topics: Animals; Antiprotozoal Agents; Arachnid Vectors; Babesiosis; Buffaloes; Cattle; Cattle Diseases; China; Diazinon; Diminazene; Imidocarb; Incidence; Insecticides; Prevalence; Seasons; Tick Control; Tick Infestations; Ticks | 1997 |
Chemotherapy of Babesia divergens in the gerbil, Meriones unguiculatus.
It was found that surprisingly low doses of four babesicides were effective against Babesia divergens in gerbils and it was concluded that this was due to the involvement of host resistance, which may be of a non-specific nature. The efficacy of the drugs relative to each other was the same in gerbils as in cattle and this host-parasite system is evidently more suitable for the screening of babesicides than are other rodent babesia systems. The prophylactic dose of imidocarb dipropionate required to provide a similar degree of protection in gerbils as in cattle was found to be much higher and was very close to toxic levels. Challenge infections resulted in sterile immunity. Acute babesiosis in gerbils could be cured with all four drugs if parasitaemias were below approximately 45 per cent and packed cell volumes above 18 per cent at treatment. Topics: Animals; Antiprotozoal Agents; Babesiosis; Carbanilides; Diminazene; Disease Models, Animal; Female; Gerbillinae; Imidocarb; Male; Quinolinium Compounds; Urea | 1983 |
Imidocarb: a chemoprophylactic experiment with Babesia canis.
Eight dogs, given imidocarb dipropionate subcutaneously at a dose of 6 mg/kg, were challenged with a sporozoite stabilate of a French strain of Babesia canis, prepared from infected Dermacentor reticulatus ticks, 2, 3, 4 or 5 weeks after treatment. Three control dogs were similarly infected but not preventively treated. One of the controls and one of the dogs treated 5 weeks prior to challenge died of babesiosis. Prepatent and incubation periods were similar in treated and control dogs, and all dogs showed important reductions in the packed cell volume. Relapses were commonly seen after recovery from the initial reaction. Although further work is needed before a final conclusion can be drawn to whether imidocarb is suitable as a chemoprophylactic against B. canis infection, it can be used as a curative drug. Topics: Amidines; Animals; Antiprotozoal Agents; Babesiosis; Carbanilides; Diminazene; Dog Diseases; Dogs; Female; Hematocrit; Imidocarb; Injections, Intramuscular; Injections, Subcutaneous; Male | 1981 |