imidazolone and 1-2-4-triazine

imidazolone has been researched along with 1-2-4-triazine* in 1 studies

Other Studies

1 other study(ies) available for imidazolone and 1-2-4-triazine

Article	Year
Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the influence of the substitution pattern in position 3 and 6 of the heterocycle on antisecretory activity, lipophilicity, and pK(a) value. Potent inhibitors of the gastric acid pump were identified. Topics: Drug Evaluation, Preclinical; Gastric Acid; Gastrointestinal Agents; Imidazoles; Isoquinolines; Molecular Structure; Proton Pump Inhibitors; Proton Pumps; Stomach; Structure-Activity Relationship; Triazines	2007

Article

Year

Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion.

Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the influence of the substitution pattern in position 3 and 6 of the heterocycle on antisecretory activity, lipophilicity, and pK(a) value. Potent inhibitors of the gastric acid pump were identified.

Topics: Drug Evaluation, Preclinical; Gastric Acid; Gastrointestinal Agents; Imidazoles; Isoquinolines; Molecular Structure; Proton Pump Inhibitors; Proton Pumps; Stomach; Structure-Activity Relationship; Triazines

2007