imidazole has been researched along with pyrroles in 118 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.54) | 18.7374 |
| 1990's | 3 (2.54) | 18.2507 |
| 2000's | 35 (29.66) | 29.6817 |
| 2010's | 62 (52.54) | 24.3611 |
| 2020's | 15 (12.71) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Dervan, PB; Wemmer, DE | 1 |
| Hélène, C | 1 |
| Baird, EE; Dervan, PB; Szewczyk, JW; Turner, JM; White, S | 1 |
| Birke, R; Lombardi, J; Vivoni, A | 1 |
| Baird, EE; Dervan, PB; Turner, JM; Wurtz, NR | 1 |
| Dervan, PB; Gottesfeld, JM; Luger, K; Melander, C; Raviol, H; Suto, RK | 1 |
| Janssen, S; Laemmli, UK; Maeshima, K | 1 |
| Kumar, R; Lown, JW | 2 |
| Liu, J; Sayre, LM; Xu, G; Yuan, Q; Zhang, WH | 1 |
| Bando, T; Sugiyama, H; Takahashi, R | 1 |
| Dervan, PB; Edelson, BS | 1 |
| HATEM, S | 1 |
| Bennani, YL; Cowart, M; Esbenshade, TA; Hancock, AA; Pratt, JK; Stewart, AO | 1 |
| Bosch, RJ; Brodie, SJ; Corey, L; Coull, JJ; Dervan, PB; Margolis, DM; Melander, C; Rucker, VC; Sodora, DL; Ylisastigui, L | 1 |
| Bailey, SL; Buchmueller, KL; Hartley, JA; Henry, JA; Hochhauser, D; Horick, SM; Howard, CM; Kotecha, M; Le, NM; Lee, M; Nguyen, B; Wilson, WD | 1 |
| Baraldi, PG; Borgatti, M; Carrion, MD; Gambari, R; Heilmann, J; Iaconinoto, MA; Romagnoli, R; Tabrizi, MA | 1 |
| Bando, T; Narita, A; Sasaki, S; Sugiyama, H | 2 |
| Mizuta, M; Seio, K; Sekine, M; Terada, T | 1 |
| Ayame, H; Bando, T; Fukuda, N; Matsuda, H; Matsumoto, K; Mugishima, H; Saito, S; Serie, K; Sugiyama, H; Tahira, Y; Ueno, T; Zhang, W | 1 |
| Baron, O; Ila, H; Knochel, P; Wagner, AJ | 1 |
| Bando, T; Minoshima, M; Sakakibara, Y; Sasaki, S; Shinohara, K; Sugiyama, H | 1 |
| Ayame, H; Fujii, Y; Hiraoka, M; Huang, LE; Iwai, A; Kageyama, Y; Kihara, K; Kizaka-Kondoh, S; Sugiyama, H | 1 |
| Bruice, TC; Canzio, D; Correa, BJ; Kahane, AL; Reddy, PM | 1 |
| Grube, A; Köck, M | 1 |
| Bhaumik, J; Borbas, KE; Lindsey, JS; Taniguchi, M; Yao, Z | 1 |
| Baraldi, PG; Fruttarolo, F; Preti, D; Romagnoli, R; Tabrizi, MA | 1 |
| Kuehr, I; Núñez, O | 1 |
| Anizon, F; Bailly, C; Golsteyn, RM; Hickman, J; Hugon, B; Léonce, S; Pfeiffer, B; Pierré, A; Prudhomme, M | 1 |
| Bando, T; Fujimoto, J; Kashiwazaki, G; Minoshima, M; Mizumura, M; Sasaki, S; Shinohara, K; Sugiyama, H | 1 |
| Bando, T; Fujimoto, J; Kashiwazaki, G; Minoshima, M; Murakami, M; Nakazono, S; Ohtsuki, A; Sasaki, S; Shinohara, K; Sugiyama, H | 1 |
| Bickmeyer, U; Grube, A; Klings, KW; Köck, M | 1 |
| Conchon, E; Golsteyn, RM; Hénon, H; Hugon, B; Messaoudi, S; Prudhomme, M | 1 |
| Dervan, PB; Harki, DA; Phelps, ME; Satyamurthy, N; Stout, DB | 1 |
| Brown, T; Bruce, C; Davis, Z; Hartley, JA; Jones, J; Kluza, J; Lajiness, JP; Lee, M; Mackay, H; Nguyen, B; O'Hare, C; Sielaff, A; Uthe, PB; Westrate, L; Wilson, WD | 1 |
| Baran, PS; O'Malley, DP; Shenvi, RA | 1 |
| Heckel, A; Schmidt, TL | 1 |
| Dervan, PB; Jacobs, CS | 1 |
| Bando, T; Kashiwazaki, G; Minoshima, M; Nishijima, S; Shinohara, K; Sugiyama, H | 1 |
| HENZE, HR; SHOWN, JH | 1 |
| Doi, T; Fuse, S; Kawauchi, S; Minoshima, M; Sugiyama, H; Takahashi, T; Tanaka, H; Tanaka, Y; Yamaguchi, S | 1 |
| Brown, T; Franks, A; Hartley, JA; Hochhauser, D; Kiakos, K; Kluza, J; Lee, M; Mackay, H; Munde, M; Tronrud, C; Wilson, WD | 1 |
| Barba-Behrens, N; Méndez, F; Richaud, A | 1 |
| Bagshaw, CR; Burley, GA; Rant, U; Schuster, M; Su, W | 1 |
| Adkins, C; Babu, B; Bruce, CD; Chavda, S; Davis, R; Ferguson, A; Franks, A; Hartley, JA; Kiakos, K; Kluza, J; Lee, M; Lin, S; Liu, Y; Mackay, H; Rice, T; Ruprich, J; Sielaff, A; Tahir, SA; Tronrud, C; Tzou, S; Westrate, L; Wilson, WD | 1 |
| Leclercq, D; Lefebvre, JF; Lo, M; Richeter, S; van der Lee, A | 1 |
| Bai, Y; Cai, S; Liu, XW; Ma, J; Zeng, J | 1 |
| Chen, XL; Guo, CX; Jiang, SK; Sugiyama, H; Wu, YL; Zhang, HF; Zhang, W | 1 |
| Babu, B; Chavda, S; David Wilson, W; Hartley, JA; Kiakos, K; Lee, M; Lin, S; Liu, Y; Ramos, J; Satam, V; Savagian, M; Sjoholm, R; Tzou, S | 1 |
| Bando, T; Endo, M; Hidaka, K; Kashiwazaki, G; Sugiyama, H; Yoshidome, T | 1 |
| Fujita, T; Fuke, Y; Fukuda, N; Kajiwara, M; Kitai, M; Matsuda, H; Matsumoto, K; Matsumoto, Y; Ra, C; Shimokawa, T; Soma, M; Tsunemi, A; Ueno, T | 1 |
| Baudron, SA; Béziau, A; Fluck, A; Hosseini, MW; Pogozhev, D | 1 |
| Chenoweth, DM; Dervan, PB; Meier, JL | 1 |
| Dervan, PB; Korf, I; Meier, JL; Segal, DJ; Yu, AS | 1 |
| Bando, T; Hashiya, K; Pandian, GN; Sugiyama, H; Vaijayanthi, T | 1 |
| Dervan, PB; Li, BC; Marinov, GK; Nickols, NG; Said, JW; Yang, F | 1 |
| Burley, GA; Clark, AW; Cooper, JM; Ravoo, BJ; Singh, I; Wendeln, C | 1 |
| Babu, B; Bingham, JP; Bowerman, M; Gregory, M; Hartley, JA; Kiakos, K; Lee, M; Liu, Y; Olson, K; Patil, P; Ramos, J; Satam, V; Savagian, M; Tzou, S; Wilson, WD | 1 |
| Bagshaw, CR; Burley, GA; Su, W | 1 |
| Babu, B; Chai, Y; David Wilson, W; Lee, M; Satam, V; Wang, S | 1 |
| Bando, T; Han, YW; Harada, Y; Hashiya, K; Kashiwazaki, G; Matsumoto, T; Morinaga, H; Sugiyama, H | 1 |
| Mazik, M; Rosien, JR; Seichter, W | 1 |
| Dervan, PB; Hamilton, SR; Li, BC; Meier, JL; Nickols, NG; Szablowski, JO; Wang, CM; Yang, F | 1 |
| Bando, Y; Dong, B; Maeda, H; Muranaka, A; Sakurai, T; Seki, S; Takaishi, K; Uchiyama, M | 1 |
| Bando, T; Hashiya, K; Kamada, F; Kawamoto, Y; Li, Y; Maeshima, K; Sugiyama, H | 1 |
| Anandhakumar, C; Bando, T; Han, L; Junetha, S; Nagase, H; Pandian, GN; Saha, A; Sato, S; Sugiyama, H; Taniguchi, J | 1 |
| Ishizuka, T; Kameshima, W; Komiyama, M; Minoshima, M; Sugiyama, H; Xu, Y; Yamamoto, M | 1 |
| Bando, T; Hashiya, K; Kawamoto, Y; Morinaga, H; Sugiyama, H; Yamamoto, M | 1 |
| Bashkin, JK; Dupureur, CM; Harris, GD; He, G; Koeller, KJ; Vasilieva, E | 1 |
| Baran, PS; Eastgate, MD; Kawamata, Y; Pan, CM; Rodriguez, RA; Yabe, Y | 1 |
| Asamitsu, S; Bando, T; Hashiya, F; Hashiya, K; Kawamoto, Y; Kizaki, S; Sugiyama, H; Yamamoto, M | 1 |
| Bando, T; Chandran, A; Hashiya, K; Pandian, GN; Sato, S; Sugiyama, H; Syed, J; Taniguchi, J | 1 |
| Anandhakumar, C; Bando, T; Hashiya, K; Kizaki, S; Li, Y; Pandian, GN; Sugiyama, H | 1 |
| Asamitsu, S; Bando, T; Guo, C; Hashiya, K; Kawamoto, Y; Sawatani, Y; Sugiyama, H | 1 |
| Chen, D; Chen, X; Li, C; Ma, M; Ma, Y | 1 |
| Bando, T; Fujiwara, K; Fukuda, N; Igarashi, J; Inoue, T; Itoh, T; Matsuda, H; Matsumoto, Y; Nagase, H; Nakai, S; Saito, K; Soma, M; Sugiyama, H; Ueno, T; Watanabe, T | 1 |
| Janssen, BM; Merkx, M; van Ommeren, SP | 1 |
| Fujiwara, K; Fukuda, N; Hanazawa, S; Masuhiro, Y; Matsuda, H; Saito, K; Shinohara, K; Soma, M; Ueno, T | 1 |
| Fukuda, N; Fukushima, A; Inami, M; Matsumoto, Y; Moriyama, M; Soma, M; Tsunemi, A; Ueno, T; Yamada, T | 1 |
| Bashkin, JK; He, G | 1 |
| Dervan, PB; Hare, AA; Hargrove, AE; Kurmis, AA; Martinez, TF; Phillips, JW; Pienta, KJ; Sud, S | 1 |
| Burley, GA; Cullis, PM; Fallows, AJ; Mackay, SP; Pauff, SM; Su, W | 1 |
| Burley, GA; Cullis, PM; Fang, L; Pan, Z; Su, W | 1 |
| Bando, T; Chandran, A; Hashiya, K; Kashiwazaki, G; Sato, S; Sugiyama, H; Syed, J; Taylor, RD | 1 |
| Bando, T; Hirata, A; Hirata, T; Ide, S; Kawamoto, Y; Maeshima, K; Murata, Y; Nokihara, K; Sasaki, A; Shimura, M; Sugiyama, H; Yamada, K | 1 |
| Chong, J; Dervan, PB; Gotte, D; Hare, AA; Li, BC; Shin, JH; Strathern, JN; Wang, D; Wang, W; Welch, TR; Xu, L; Yang, F | 1 |
| Asamitsu, S; Bando, T; Guo, C; Kashiwazaki, G; Sato, S; Sugiyama, H | 1 |
| Bewley, CA; Liu, HB; Melander, C; Melander, RJ; Stephens, MD | 1 |
| Al Mourabit, A; Moriou, C; Sauleau, P | 1 |
| Bando, T; Hashiya, K; Kashiwazaki, G; Kawase, T; Maeda, R; Sugiyama, H | 1 |
| Bando, T; Guo, C; Hashiya, K; Sugiyama, H; Wei, Y; Yu, Z | 1 |
| Edwards, TG; Fisher, C | 1 |
| Ao, L; Chen, J; Ding, Z; Fang, L; Li, H; Liu, K; Liu, X; Pan, Z; Shao, X; Su, W; Sun, H; Tan, Y; Wang, R; Wang, W; Wu, C; Zhang, J | 1 |
| Boutorine, AS; Cardoso, GM; Escudé, C; Loll, F; Nozeret, K | 1 |
| Dervan, PB; Diaz-Perez, S; Kane, N; Kummer, NT; Kurmis, AA; Nickols, NG; Yang, F | 1 |
| Asamitsu, S; Bando, T; Hashiya, K; Hsieh, WC; Ly, DH; Sugiyama, H; Yu, Z | 1 |
| Inoue, T; Koshikawa, N; Lin, J; Nagase, H; Shinozaki, Y; Takatori, A; Watanabe, T; Yoda, H | 1 |
| Burley, GA; Fang, L; Gómez-Castañeda, E; Hayatigolkhatmi, K; Hsieh, YC; Jackson, L; Jørgensen, HG; Padroni, G; Pellicano, F; Su, W | 1 |
| Denda, T; Hara, T; Kitagawa, Y; Kitano, S; Nagase, H; Nankinzan, R; Okumura, K; Soda, H; Suzuki, T; Tsukamoto, K; Watanabe, T; Yamaguchi, T | 1 |
| Abe, M; Endo, M; Fukuda, N; Horikoshi, S; Inoue, T; Mineshige, T; Otsuki, M; Otsuki, T | 1 |
| Ding, Y; Lan, HT; Qin, HX; Xu, ZG; Yang, DL; Yi, C; Zhang, M | 1 |
| Hasegawa, K; Hidaka, T; Horie, M; Kumar, A; Malinee, M; Pandian, GN; Sugiyama, H | 1 |
| Heinrich, B; Vázquez, O | 1 |
| Fan, T; He, X; Huang, X; Liu, R; Ruan, Q; Su, W; Wang, T; Wu, C | 1 |
| Abe, K; Bando, T; Eki, H; Endo, M; Hirose, Y; Sugiyama, H; Takeda, K | 1 |
| Ang, YS; Bando, T; Sugiyama, H; Yung, LL | 1 |
| An, J; De, D; Kang, TM; Kashiwazaki, G; Kim, KK; Lee, JA; Pandian, GN; Parveen, N; Sugiyama, H; Taniguchi, J | 1 |
| Hidaka, T; Sugiyama, H | 1 |
| Ali, A; Ansari, AZ; Bhimsaria, D; Dervan, PB; Eguchi, A; Finn, PB | 1 |
| Herath, AK; Lovely, CJ | 1 |
| Kida, Y; Koshikawa, N; Nagase, H; Shinozaki, Y; Takenaga, K; Tsuji, K; Watanabe, T; Yasui, N | 1 |
| Abu-Hashem, AA; Al-Hussain, SA; Zaki, MEA | 1 |
| Cheng, B; Cheng, Y; Ding, Z; Fang, L; Li, H; Li, M; Li, Y; Lin, X; Liu, K; Lu, D; Shao, X; Shi, W; Su, W; Wu, C; Zhang, J | 1 |
| Chong, J; Dervan, PB; Jia, T; Oh, J; Wang, D; Xu, J | 1 |
| Kida, Y; Koshikawa, N; Lin, J; Nagase, H; Shinozaki, Y; Takenaga, K; Tsuji, K; Watanabe, T; Yamamoto, S | 1 |
7 review(s) available for imidazole and pyrroles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Targeting the minor groove of DNA.
Topics: DNA; Drug Design; Humans; Imidazoles; Ligands; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles; Substrate Specificity | 1997 |
Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
Topics: Base Sequence; Benzimidazoles; Binding Sites; DNA; DNA-Binding Proteins; Gene Expression Regulation; Imidazoles; Molecular Sequence Data; Nucleic Acid Conformation; Nylons; Pyrroles | 2003 |
Hybrid molecules between distamycin A and active moieties of antitumor agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Distamycins; DNA; Humans; Imidazoles; Molecular Structure; Nylons; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2007 |
Pyrrolocarbazoles as checkpoint 1 kinase inhibitors.
Topics: Carbazoles; Checkpoint Kinase 1; Cyclization; Humans; Imidazoles; Models, Biological; Models, Molecular; Protein Kinase Inhibitors; Protein Kinases; Pyrroles | 2008 |
Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole-Imidazole Polyamides.
Topics: DNA; Humans; Imidazoles; Nylons; Pyrroles; Transcription Factors | 2021 |
Pyrrole carboxamide introduction in the total synthesis of pyrrole-imidazole alkaloids.
Topics: Alkaloids; Imidazoles; Molecular Structure; Pyrroles | 2021 |
111 other study(ies) available for imidazole and pyrroles
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
DNA recognition. Reading the minor groove.
Topics: Base Composition; DNA; Humans; Imidazoles; Ligands; Nucleic Acid Conformation; Nylons; Pyrroles | 1998 |
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands.
Topics: Amino Acids; Base Composition; DNA; DNA Footprinting; Hydrogen Bonding; Imidazoles; Ligands; Molecular Conformation; Nylons; Pyrroles | 1998 |
Optimization of force constants with an Urey-Bradley force field avoiding normal mode crossings.
Topics: Adenine; Aniline Compounds; Benzene; Chemical Phenomena; Chemistry, Physical; Heterocyclic Compounds; Imidazoles; Models, Chemical; Molecular Structure; Organic Chemicals; Pyridines; Pyrimidines; Pyrroles; Software | 2001 |
Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids.
Topics: Amino Acids; Chromatography, High Pressure Liquid; DNA; Fluorenes; Imidazoles; Ligands; Models, Chemical; Peptide Biosynthesis; Peptides; Pyrroles; Resins, Plant | 2001 |
Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.
Topics: Base Sequence; Binding Sites; Deoxyribonuclease I; DNA; DNA Footprinting; DNA, Satellite; Histones; Hydroxyl Radical; Imidazoles; Models, Molecular; Molecular Probes; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosomes; Nylons; Pyrroles; Substrate Specificity; Thermodynamics | 2001 |
Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides.
Topics: Animals; Cell Line; DNA-Binding Proteins; Fluorescence; HeLa Cells; Humans; Imidazoles; Nylons; Pyrroles; Repetitive Sequences, Nucleic Acid; Spodoptera; Staining and Labeling; Telomere; Telomeric Repeat Binding Protein 1 | 2001 |
Synthesis and antitumor cytotoxicity evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine imidazole containing polyamide conjugates.
Topics: Animals; Benzodiazepines; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Imidazoles; Mice; Nylons; Pyrroles; Tumor Cells, Cultured | 2003 |
Model studies on protein side chain modification by 4-oxo-2-nonenal.
Topics: Acetylcysteine; Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Histidine; Imidazoles; Linoleic Acid; Lysine; Magnetic Resonance Spectroscopy; Oxygen; Proteins; Pyrroles; Ribonucleases; Stereoisomerism; Structure-Activity Relationship | 2003 |
Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide.
Topics: Adenine; Alkylation; Antineoplastic Agents, Alkylating; Cell Division; Cell Line, Tumor; DNA; Humans; Imidazoles; Inhibitory Concentration 50; Nucleic Acid Conformation; Nylons; Oligonucleotides; Pyrroles; Repetitive Sequences, Nucleic Acid; Telomere | 2003 |
[Imidazole-pyrrole complex in the aqueous phase and preferential fixation of 3,4-benzopyrene by the medium].
Topics: Benzo(a)pyrene; Benzopyrenes; Imidazoles; Pyrroles | 1959 |
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo [2,1][1,4] benzodiazepine-glycosylated pyrrole and imidazole polyamide conjugates.
Topics: Benzodiazepines; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening Assays, Antitumor; Glycosylation; Humans; Imidazoles; Molecular Structure; Nylons; Pyrroles | 2003 |
A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.
Topics: Amines; Animals; Benzofurans; Central Nervous System; Histamine Antagonists; Humans; Imidazoles; Molecular Structure; Piperidines; Pyrroles; Pyrrolidines; Rats; Receptors, Histamine H3; Structure-Activity Relationship | 2004 |
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Enzyme Inhibitors; Histone Deacetylases; HIV Core Protein p24; HIV Infections; HIV Long Terminal Repeat; HIV-1; Humans; Imidazoles; Nylons; Pyrroles; RNA, Viral; Virus Latency | 2004 |
Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Base Sequence; Calorimetry; Circular Dichroism; Deoxyribonuclease I; DNA; DNA Footprinting; DNA Topoisomerases, Type II; DNA-Binding Proteins; Imidazoles; Nucleic Acid Conformation; Nucleic Acid Denaturation; Nylons; Promoter Regions, Genetic; Pyrroles; Response Elements; Substrate Specificity; Surface Plasmon Resonance; Temperature; Thermodynamics; Titrimetry | 2004 |
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzofurans; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Imidazoles; Mice; Molecular Structure; Netropsin; Pyrazoles; Pyrroles; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2005 |
Specific adenine alkylation by pyrrole-imidazole CBI conjugates.
Topics: Adenine; Alkylation; Crystallography, X-Ray; Cyclopropanes; Imidazoles; Indoles; Models, Molecular; Molecular Structure; Nylons; Pyrroles | 2005 |
Use of ferrocene scaffolds as pendant groups in hairpin-type pyrrole-imidazole polyamide molecules showing sequence-selective binding to DNA duplexes.
Topics: Base Sequence; Binding Sites; DNA; Ferrous Compounds; Imidazoles; Metallocenes; Molecular Conformation; Nylons; Pyrroles | 2005 |
Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases.
Topics: Animals; Cell Culture Techniques; Gene Silencing; Imidazoles; Kidney Diseases; Mesangial Cells; Nylons; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Inbred Dahl; Rats, Wistar; RNA, Messenger; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocycles.
Topics: Antipyrine; Combinatorial Chemistry Techniques; Esters; Furans; Heterocyclic Compounds; Imidazoles; Imines; Iodides; Magnesium; Models, Chemical; Nitriles; Organometallic Compounds; Pyridines; Pyrroles; Quinolines; Thiazoles; Thiophenes; Uracil | 2006 |
Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker.
Topics: Adenine; Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Cyclopropanes; Humans; Imidazoles; Indoles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neoplasms; Nucleic Acid Conformation; Nylons; Polymerase Chain Reaction; Pyrroles; Thymine | 2006 |
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element.
Topics: Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Renal Cell; Cell Hypoxia; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Models, Biological; Molecular Sequence Data; Nylons; Protein Binding; Pyrroles; Response Elements; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2006 |
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.
Topics: Adenine; Base Pairing; Base Sequence; Bisbenzimidazole; Cytosine; DNA; Guanine; Imidazoles; Molecular Sequence Data; Nylons; Peptides; Pyrroles; Temperature; Thymine | 2006 |
Stylissadines A and B: the first tetrameric pyrrole-imidazole alkaloids.
Topics: Alkaloids; Animals; Bacteria; Caribbean Region; Fibroblasts; Fungi; Imidazoles; Mice; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Porifera; Pyrroles | 2006 |
Masked imidazolyl-dipyrromethanes in the synthesis of imidazole-substituted porphyrins.
Topics: Imidazoles; Molecular Conformation; Porphyrins; Pyrroles; Stereoisomerism | 2006 |
Molecular design of alkylating pyrrole-imidazole polyamides with indole linker.
Topics: Alkylation; Imidazoles; Indoles; Nylons; Pyrroles | 2004 |
Titanium dioxide photoinduced degradation of some pesticide/fungicide precursors.
Topics: Adsorption; Environmental Pollutants; Environmental Restoration and Remediation; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Pesticides; Pyrroles; Titanium; Triazoles; Ultraviolet Rays | 2007 |
Synthesis and biological activities of isogranulatimide analogues.
Topics: Aza Compounds; Carbazoles; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; DNA; DNA Topoisomerases, Type I; Humans; Imidazoles; Indoles; Magnetic Resonance Spectroscopy; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; src-Family Kinases; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2007 |
Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides.
Topics: Base Sequence; DNA; Fluorescence; Imidazoles; Nylons; Oligodeoxyribonucleotides; Pyrenes; Pyrroles; Sequence Analysis, DNA; Spectrometry, Fluorescence; Trinucleotide Repeats | 2007 |
Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition.
Topics: Alanine; Alkylation; Base Pairing; Base Sequence; DNA; Imidazoles; Pyrroles; Temperature | 2008 |
Ageladine A, a pyrrole-imidazole alkaloid from marine sponges, is a pH sensitive membrane permeable dye.
Topics: Agelas; Alkaloids; Animals; Cell Membrane; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Imidazoles; PC12 Cells; Permeability; Pyrroles; Rats | 2008 |
In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.
Topics: Animals; Binding Sites; Deoxyribonuclease I; DNA; DNA Footprinting; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Imidazoles; Male; Mice; Mice, Inbred C57BL; Nylons; Oximes; Positron-Emission Tomography; Pyrroles; Radiometry; Tomography, X-Ray Computed; Whole Body Imaging | 2008 |
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Topics: Base Sequence; Calorimetry; Circular Dichroism; Computer Simulation; Imidazoles; Models, Molecular; Nucleic Acid Denaturation; Nylons; Pyrroles; Surface Plasmon Resonance; Thermodynamics; Titrimetry | 2008 |
Chemoselectivity: the mother of invention in total synthesis.
Topics: Alkaloids; Biological Products; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Indole Alkaloids; Indoles; Lactones; Lignans; Neuropeptides; Pyrroles | 2009 |
Pyrrole/imidazole-polyamide anchors for DNA tertiary interactions.
Topics: Binding Sites; Biocompatible Materials; Crystallization; DNA; Imidazoles; Materials Testing; Nanostructures; Nanotechnology; Nucleic Acid Conformation; Nylons; Pyrroles; Surface Properties | 2009 |
Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.
Topics: Androgens; Base Sequence; Cell Line; Cell Proliferation; Cell Survival; DNA; Gene Expression Regulation; Imidazoles; Inhibitory Concentration 50; Nucleic Acid Denaturation; Nylons; Oximes; Pyrroles; Response Elements; Transition Temperature | 2009 |
Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Chlorambucil; DNA; Humans; Imidazoles; Lymphocytes; Molecular Structure; Neoplasms; Nylons; Pyrroles | 2010 |
Pyrrole formation during attempted hydantoin synthesis.
Topics: Anticonvulsants; Hydantoins; Imidazoles; Pyrroles | 1947 |
Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity.
Topics: DNA; DNA Cleavage; Enediynes; Imidazoles; Nylons; Photosensitizing Agents; Pyrroles; Ultraviolet Rays | 2010 |
Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.
Topics: Animals; Antigens, Neoplasm; Binding Sites; Calorimetry; Cell Line; Circular Dichroism; DNA Topoisomerases, Type II; DNA-Binding Proteins; Formamides; Imidazoles; Mice; Nylons; Promoter Regions, Genetic; Protein Denaturation; Pyrroles; Surface Plasmon Resonance; Transition Temperature | 2010 |
Chemical reactivity of the imidazole: a semblance of pyridine and pyrrole?
Topics: Amines; Aza Compounds; Imidazoles; Molecular Structure; Pyridines; Pyrroles | 2011 |
Site-specific assembly of DNA-based photonic wires by using programmable polyamides.
Topics: Carbocyanines; DNA; Fluorescence Resonance Energy Transfer; Imidazoles; Nylons; Photons; Pyrroles | 2011 |
Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.
Topics: Base Sequence; Calorimetry; Circular Dichroism; Deoxyribonuclease I; DNA; Drug Design; Fluorescent Dyes; Imidazoles; Micrococcal Nuclease; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles; Spectrometry, Fluorescence; Substrate Specificity; Surface Plasmon Resonance | 2011 |
Stepwise fusion of porphyrin β,β'-pyrrolic positions to imidazole rings.
Topics: Imidazoles; Metalloporphyrins; Molecular Structure; Nickel; Pyrroles | 2011 |
Direct synthesis of pyrroles via a silver-promoted three-component reaction involving unusual imidazole ring opening.
Topics: Aldehydes; Alkynes; Hydrolysis; Imidazoles; Isotope Labeling; Pyrroles; Silver | 2011 |
Discrimination between T/A and A/T base pairs of pyrrole-imidazole polyamides substituted with chiral β-hydroxy-γ-aminobutyric acid/β-alanine pairs.
Topics: Aminobutyrates; AT Rich Sequence; Base Pairing; Base Sequence; beta-Alanine; DNA; Hydrogen Bonding; Imidazoles; Kinetics; Nylons; Pyrroles | 2012 |
Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.
Topics: Base Sequence; Benzamides; Calorimetry; Circular Dichroism; Deoxyribonuclease I; Distamycins; DNA; Imidazoles; Nylons; Pyrroles; Surface Plasmon Resonance | 2012 |
Sequence-selective single-molecule alkylation with a pyrrole-imidazole polyamide visualized in a DNA nanoscaffold.
Topics: Alkylation; Base Sequence; DNA; Imidazoles; Microscopy, Atomic Force; Nylons; Pyrroles | 2012 |
Development of pyrrole-imidazole polyamide targeting fc receptor common gamma chain for the treatment of immune-complex related renal disease.
Topics: Animals; Cell Line; Cells, Cultured; Gene Expression Regulation; Imidazoles; Immune Complex Diseases; Kidney Diseases; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Nylons; Promoter Regions, Genetic; Pyrroles; Receptors, IgG; RNA, Messenger | 2012 |
Stepwise construction of grid-type Cu(II)-Cd(II) heterometallic MOFs based on an imidazole-appended dipyrrin ligand.
Topics: Cadmium; Copper; Imidazoles; Ligands; Molecular Structure; Organometallic Compounds; Pyrroles | 2012 |
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
Topics: Binding Sites; DNA; Imidazoles; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles; RNA | 2013 |
Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.
Topics: DNA; Gene Library; High-Throughput Nucleotide Sequencing; Imidazoles; Nylons; Pyrroles | 2012 |
Design of a new fluorescent probe: pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn.
Topics: Fluorescent Dyes; Imidazoles; Nylons; Oligodeoxyribonucleotides; Pyrenes; Pyrroles; Spectrometry, Fluorescence | 2013 |
Antitumor activity of a pyrrole-imidazole polyamide.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Imidazoles; Immunoblotting; Interleukin Receptor Common gamma Subunit; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Nylons; Prostatic Neoplasms; Proteasome Inhibitors; Protein Subunits; Pyrroles; RNA Polymerase II; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
Sequence-selective detection of double-stranded DNA sequences using pyrrole-imidazole polyamide microarrays.
Topics: Base Pairing; Base Sequence; Binding Sites; Click Chemistry; DNA; Imidazoles; Molecular Structure; Nylons; Oligonucleotide Array Sequence Analysis; Pyrroles | 2013 |
Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.
Topics: Amides; Anisoles; Base Pairing; Benzimidazoles; Circular Dichroism; DNA; Fluorescent Dyes; Imidazoles; Nucleic Acid Conformation; Pyrroles | 2013 |
Addressable and unidirectional energy transfer along a DNA three-way junction programmed by pyrrole-imidazole polyamides.
Topics: DNA; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Imidazoles; Nylons; Optics and Photonics; Pyrroles | 2013 |
Conformational modulation of DNA by polyamide binding: structural effects of f-Im-Py-Im based derivatives on 5'-ACGCGT-3'.
Topics: Amines; Base Sequence; Benzamides; DNA; Electrophoresis, Polyacrylamide Gel; Formamides; Humans; Imidazoles; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles | 2013 |
Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5'-GCGC-3'.
Topics: Base Pair Mismatch; Base Sequence; beta-Alanine; DNA; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles; Surface Plasmon Resonance | 2013 |
Trimethoxybenzene- and trimethylbenzene-based compounds bearing imidazole, indole and pyrrole groups as recognition units: synthesis and evaluation of the binding properties towards carbohydrates.
Topics: Benzene Derivatives; Binding Sites; Carbohydrates; Imidazoles; Indoles; Models, Molecular; Molecular Structure; Pyrroles | 2013 |
Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.
Topics: Animals; Antineoplastic Agents; Biological Transport; Body Weight; Dose-Response Relationship, Drug; Drug Stability; Humans; Imidazoles; Liver; Male; Mice; Microsomes, Liver; Nylons; Pyrroles; Structure-Activity Relationship; Toxicity Tests; Xenograft Model Antitumor Assays | 2013 |
Ion-based materials derived from positively and negatively charged chloride complexes of π-conjugated molecules.
Topics: Chlorides; Gels; Imidazoles; Ions; Models, Molecular; Pyrimidines; Pyrroles | 2013 |
Development of a new method for synthesis of tandem hairpin pyrrole-imidazole polyamide probes targeting human telomeres.
Topics: Animals; Cell Line; Fluorescent Dyes; HeLa Cells; Humans; Imidazoles; Mice; Molecular Structure; Nylons; Pyrroles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Staining and Labeling; Telomere | 2013 |
A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell.
Topics: Germ Cells; Humans; Hydroxamic Acids; Imidazoles; Molecular Structure; Nylons; Pluripotent Stem Cells; Pyrroles; Transcriptional Activation | 2013 |
Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA.
Topics: Amides; DNA; DNA Cleavage; Imidazoles; Peptide Nucleic Acids; Pyrroles | 2013 |
Sequence-specific DNA recognition by cyclic pyrrole-imidazole cysteine-derived polyamide dimers.
Topics: Base Sequence; Cysteine; Dimerization; DNA; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles; Surface Plasmon Resonance | 2014 |
Binding studies of a large antiviral polyamide to a natural HPV sequence.
Topics: Alanine; Antiviral Agents; Binding Sites; DNA; Human papillomavirus 16; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles | 2014 |
Palau'chlor: a practical and reactive chlorinating reagent.
Topics: Alkaloids; Guanidine; Halogenation; Hydrocarbons, Chlorinated; Imidazoles; Indicators and Reagents; Models, Molecular; Pyrroles | 2014 |
Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats.
Topics: Alkylation; Chlorambucil; DNA; Imidazoles; Nylons; Pyrroles; Structure-Activity Relationship; Transcription, Genetic; Trinucleotide Repeats | 2014 |
Targeted suppression of EVI1 oncogene expression by sequence-specific pyrrole-imidazole polyamide.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Movement; DNA-Binding Proteins; Down-Regulation; ets-Domain Protein Elk-1; Humans; Imidazoles; MDS1 and EVI1 Complex Locus Protein; Nylons; Peptides; Promoter Regions, Genetic; Proto-Oncogene Proteins c-rel; Proto-Oncogenes; Pyrroles; RNA, Messenger; Transcription Factors; Up-Regulation | 2014 |
Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of β-alanine.
Topics: Base Sequence; beta-Alanine; Binding Sites; DNA; High-Throughput Nucleotide Sequencing; Imidazoles; Nylons; Pyrroles | 2014 |
Rational design of specific binding hairpin Py-Im polyamides targeting human telomere sequences.
Topics: Base Sequence; DNA; Humans; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles; Surface Plasmon Resonance; Telomere | 2015 |
Electrochemical fabrication of polymerized imidazole-based ionic liquid bearing pyrrole moiety for sensitive determination of hexestrol in chicken meat.
Topics: Animals; Chickens; Hexestrol; Imidazoles; Ionic Liquids; Polymerization; Pyrroles | 2015 |
Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
Topics: Animals; Base Sequence; Binding Sites; Callithrix; Cicatrix, Hypertrophic; Disease Models, Animal; Gene Silencing; Gene Targeting; Humans; Imidazoles; Injections; Male; Molecular Sequence Data; Nylons; Ointments; Promoter Regions, Genetic; Pyrroles; RNA, Messenger; Transforming Growth Factor beta1 | 2015 |
Efficient Synthesis of Peptide and Protein Functionalized Pyrrole-Imidazole Polyamides Using Native Chemical Ligation.
Topics: DNA; Imidazoles; Molecular Structure; Nylons; Peptides; Pyrroles; Recombinant Proteins; Surface Plasmon Resonance | 2015 |
Modulation of the EMT/MET process by pyrrole-imidazole polyamide targeting human transforming growth factor-β1.
Topics: Blotting, Western; Cadherins; Cell Line; Cells, Cultured; Cellular Reprogramming; Epithelial-Mesenchymal Transition; Fibroblasts; Gene Expression; Humans; Imidazoles; Induced Pluripotent Stem Cells; Microscopy, Confocal; Nylons; Promoter Regions, Genetic; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor beta1 | 2015 |
Reduction of Dimethylnitrosamine-Induced Liver Fibrosis by the Novel Gene Regulator PI Polyamide Targeting Transforming Growth Factor β1 Gene.
Topics: Actins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; End Stage Liver Disease; Fibrosis; Gene Silencing; Hepatic Stellate Cells; Imidazoles; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Matrix Metalloproteinase 2; Pyrroles; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2015 |
What is the antiviral potential of pyrrole-imidazole polyamides?
Topics: Antiviral Agents; DNA, Viral; Humans; Imidazoles; Microbial Sensitivity Tests; Nylons; Pyrroles; Virus Diseases; Viruses | 2015 |
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Damage; DNA Topoisomerases; Gene Expression Regulation; Humans; Imidazoles; Male; Mice; Nylons; Oncogene Proteins, Fusion; Prostatic Neoplasms; Protein Binding; Pyrroles; Receptors, Androgen; Sequence Analysis, RNA; Transplantation, Heterologous | 2015 |
Pyrrole-Imidazole Polyamides: Manual Solid-Phase Synthesis.
Topics: Imidazoles; Polyamines; Pyrroles | 2015 |
Pyrrole-Imidazole Polyamides: Automated Solid-Phase Synthesis.
Topics: Automation; Imidazoles; Polyamines; Pyrroles | 2015 |
Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing.
Topics: Alkylating Agents; Alkylation; Base Sequence; DNA; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Imidazoles; Nylons; Promoter Regions, Genetic; Pyrroles; Receptor, ErbB-2 | 2016 |
Telomere Visualization in Tissue Sections using Pyrrole-Imidazole Polyamide Probes.
Topics: Animals; Cytological Techniques; DNA; Histocytochemistry; Humans; Imidazoles; Mice; Nylons; Optical Imaging; Pyrroles; Staining and Labeling; Telomere | 2016 |
RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.
Topics: Amino Acid Sequence; Binding Sites; DNA; Imidazoles; Models, Molecular; Nucleic Acid Conformation; Nylons; Protein Binding; Protein Domains; Pyrroles; RNA Polymerase II; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription, Genetic | 2016 |
DNA Interstrand Crosslinks by H-pin Polyamide (S)-seco-CBI Conjugates.
Topics: Alkylation; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Cell Survival; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; Indoles; Intercalating Agents; Plasmids; Pyrroles; Stereoisomerism | 2017 |
Marine sponge alkaloids as a source of anti-bacterial adjuvants.
Topics: Acinetobacter baumannii; Alkaloids; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Imidazoles; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Porifera; Pyrroles; Structure-Activity Relationship | 2016 |
Metabolomics approach to chemical diversity of the Mediterranean marine sponge Agelas oroides.
Topics: Agelas; Alkaloids; Animals; Biological Products; Imidazoles; Metabolomics; Porifera; Pyrroles | 2017 |
Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer.
Topics: Alkylation; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Humans; Imidazoles; Molecular Structure; Nylons; Pyrroles; Structure-Activity Relationship | 2018 |
Pip-HoGu: An Artificial Assembly with Cooperative DNA Recognition Capable of Mimicking Transcription Factor Pairs.
Topics: Adamantane; Cell Line, Tumor; Cyclodextrins; DNA; Humans; Imidazoles; Molecular Structure; Nylons; Pyrroles; Transcription Factors | 2018 |
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses.
Topics: Antiviral Agents; BK Virus; DNA Replication; Humans; Imidazoles; Nylons; Polyomavirus Infections; Pyrroles; Simian virus 40; Tumor Virus Infections | 2018 |
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Female; Fluorescent Dyes; HeLa Cells; Humans; Imidazoles; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Nylons; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyrroles; Xenograft Model Antitumor Assays | 2018 |
Interaction of fluorescently labeled pyrrole-imidazole polyamide probes with fixed and living murine and human cells.
Topics: Animals; Binding Sites; Cell Line; Cell Tracking; Chromatin; Fluorescent Dyes; Humans; Imidazoles; Mice; Nylons; Pyrroles; Staining and Labeling | 2018 |
Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.
Topics: Cell Line, Tumor; DNA; DNA Damage; DNA Ligase ATP; DNA Repair; Humans; Imidazoles; Nylons; Pyrroles; Radiation, Ionizing; Small Molecule Libraries; X-ray Repair Cross Complementing Protein 1 | 2018 |
Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs.
Topics: Base Sequence; Binding Sites; Circular Dichroism; Dimerization; DNA; Electrophoretic Mobility Shift Assay; Imidazoles; Nylons; Peptide Nucleic Acids; Pyrroles; Thermodynamics; Transcription Factors | 2018 |
Direct Targeting of
Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nylons; Pyrroles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells.
Topics: Antineoplastic Agents; Blast Crisis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; E2F1 Transcription Factor; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Nylons; Protein Kinase Inhibitors; Pyrroles; Structure-Activity Relationship | 2019 |
Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Cell Line, Tumor; Cell-Free Nucleic Acids; Circulating Tumor DNA; Codon; Colorectal Neoplasms; DNA, B-Form; Early Detection of Cancer; Female; Humans; Imidazoles; Male; Middle Aged; Mutation; Nylons; Proto-Oncogene Proteins p21(ras); Pyrroles | 2019 |
Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset.
Topics: Animals; Base Sequence; Cadherins; Callithrix; Cyclosporine; DNA; Fibrosis; Humans; Imidazoles; Kidney; Kidney Diseases; Nylons; Peptides; Promoter Regions, Genetic; Pyrroles; RNA, Messenger; Snail Family Transcription Factors; Transforming Growth Factor beta1; Urethral Obstruction | 2019 |
One-pot synthesis of substituted pyrrole-imidazole derivatives with anticancer activity.
Topics: Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Humans; Imidazoles; Pyrroles | 2020 |
Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide.
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Mice; Molecular Structure; Nylons; Pyrroles; RNA, Messenger; SOXB1 Transcription Factors; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
4-Methyltrityl-Protected Pyrrole and Imidazole Building Blocks for Solid Phase Synthesis of DNA-Binding Polyamides.
Topics: Binding Sites; DNA; Imidazoles; Molecular Structure; Nylons; Pyrroles; Solid-Phase Synthesis Techniques | 2020 |
Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide.
Topics: Animals; Autoimmune Diseases; Female; Gene Silencing; Imidazoles; Imiquimod; Interleukin-23 Subunit p19; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Nylons; Psoriasis; Pyrroles; Uveitis | 2020 |
X-ray Crystal Structure of a Cyclic-PIP-DNA Complex in the Reverse-Binding Orientation.
Topics: Binding Sites; Crystallography, X-Ray; DNA; Imidazoles; Models, Molecular; Molecular Structure; Nylons; Pyrroles | 2020 |
Dynamic Stabilization of DNA Assembly by Using Pyrrole-Imidazole Polyamide.
Topics: DNA; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles | 2020 |
Targeted epigenetic modulation using a DNA-based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells.
Topics: Animals; Biomarkers; Cell Differentiation; DNA; Embryoid Bodies; Endoderm; Epigenesis, Genetic; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Imidazoles; Mesoderm; Mice; Models, Biological; Mouse Embryonic Stem Cells; Myocytes, Cardiac; Nucleotide Motifs; Nylons; Organogenesis; Pyrroles; RNA, Messenger; Transcription, Genetic | 2021 |
Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome.
Topics: DNA-Binding Proteins; Genome, Human; Humans; Imidazoles; Nucleic Acid Conformation; Nylons; Pyrroles | 2020 |
A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.
Topics: Cell Survival; DNA, Mitochondrial; HeLa Cells; Humans; Imidazoles; Mitochondria; Mitophagy; Mutation; Neoplasms; Nylons; Pyrroles; Reactive Oxygen Species; Sulfonium Compounds; Surface Plasmon Resonance | 2021 |
Design, Synthesis and Anticancer Activity of New Polycyclic: Imidazole, Thiazine, Oxathiine, Pyrrolo-Quinoxaline and Thienotriazolopyrimidine Derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Pyrimidines; Pyrroles; Quinoxalines; Structure-Activity Relationship; Thiazines | 2021 |
A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase A; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Nylons; Protein Kinase Inhibitors; Pyrroles; Tumor Cells, Cultured | 2021 |
RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Topics: Base Sequence; DNA; Imidazoles; Models, Molecular; Nucleic Acid Conformation; Pyrroles; RNA Polymerase II; Transcription, Genetic; Transcriptional Elongation Factors | 2022 |
Suppression of non-small-cell lung cancer A549 tumor growth by an mtDNA mutation-targeting pyrrole-imidazole polyamide-triphenylphosphonium and a senolytic drug.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA, Mitochondrial; Humans; Imidazoles; Lung Neoplasms; Mutation; Nylons; Pyrroles; Senotherapeutics | 2022 |