imidaprilat has been researched along with imidazolidines in 28 studies
| Studies (imidaprilat) | Trials (imidaprilat) | Recent Studies (post-2010) (imidaprilat) | Studies (imidazolidines) | Trials (imidazolidines) | Recent Studies (post-2010) (imidazolidines) |
|---|---|---|---|---|---|
| 30 | 5 | 2 | 1,666 | 186 | 358 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (53.57) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeo, T; Kaburaki, M; Kikkawa, K; Kurosawa, H; Murata, S; Narita, H; Yabana, H; Yamaguchi, I | 1 |
| Iga, T; Ito, K; Kamei, J; Misawa, M; Sawada, Y | 1 |
| Mizobe, M; Noda, K; Tagawa, K | 1 |
| Ishida, R; Ogiku, N; Sumikawa, H | 1 |
| Banno, K; Ishibashi, K; Ito, M; Mizobe, M; Morikawa, S; Murata, K; Sato, T; Suzuki, T; Takai, T; Yamanaka, K | 1 |
| Banno, K; Murata, K; Sato, T; Takehara, N; Yamanaka, K | 2 |
| Hoogkamer, JF; Kirch, W; Kleinbloesem, CH; Lankhaar, G; Nokhodian, A; Ouwerkerk, MJ; Ungethüm, W | 2 |
| Harder, S; Thürmann, PA | 1 |
| Obata, T; Yamanaka, Y | 2 |
| Asanuma, H; Hori, M; Kitakaze, M; Kosaka, H; Kuzuya, T; Minamino, T; Node, K; Ueda, Y | 1 |
| Obata, T | 3 |
| Fukuyama, T; Kano, Y; Kondo, T; Mabuchi, M | 1 |
| Giddings, JC; Noguchi, T; Sasaki, Y; Seki, J; Yamamoto, J | 1 |
| Fujimura, A; Sakamoto, K; Sugimoto, K | 1 |
| Doi, H; Narita, H | 1 |
| Russell, ST; Sanders, PM; Tisdale, MJ | 1 |
| Kawakami, A; Kojima, C; Nitta, K; Takei, T; Yoshida, M | 1 |
| Chen, JZ; Guo, XG; Lee, JD; Mizuguchi, T; Ueda, T; Uzui, H | 1 |
| Katoh, M; Nakajima, M; Saitoh, T; Takahashi, S; Yokoi, T | 1 |
| Ichihara, A; Itoh, H; Kinouchi, K; Kurauchi-Mito, A; Murohashi-Bokuda, K; Narita, T; Nishiyama, A; Sakoda, M; Saleem, MA; Suzuki, F | 1 |
| Ino, J; Ishii, H; Kojima, C; Nitta, K; Yoshida, M | 1 |
| Akashi, H; Aoki, H; Aoyagi, S; Furusho, A; Hiromatsu, S; Imaizumi, T; Nishihara, M; Ohno, S; Shintani, Y | 1 |
| Jin, D; Li, ZL; Miyazaki, M; Otsuki, Y; Takai, S; Yamamoto, D | 1 |
5 trial(s) available for imidaprilat and imidazolidines
| Article | Year |
|---|---|
A saturable tissue-angiotensin I converting enzyme (ACE) binding model for the pharmacokinetic analysis of imidapril, a new ACE inhibitor, and its active metabolite in human.
Topics: Angiotensin-Converting Enzyme Inhibitors; Biological Availability; Half-Life; Humans; Imidazoles; Imidazolidines; Male; Peptidyl-Dipeptidase A; Regression Analysis | 1995 |
Radioimmunoassay for imidapril, a new angiotensin-converting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antibody Specificity; Chromatography, High Pressure Liquid; Cross Reactions; Humans; Imidazoles; Imidazolidines; Immunoconjugates; Indicators and Reagents; Male; Radioimmunoassay; Radioligand Assay | 1996 |
Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with impaired liver function.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Area Under Curve; Biotransformation; Half-Life; Humans; Imidazoles; Imidazolidines; Liver Diseases; Liver Function Tests | 1997 |
Pharmacokinetic and pharmacodynamic interaction trial after repeated oral doses of imidapril and digoxin in healthy volunteers.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Area Under Curve; Cross-Over Studies; Digoxin; Double-Blind Method; Drug Interactions; Half-Life; Humans; Imidazoles; Imidazolidines; Radioimmunoassay | 1997 |
Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with chronic renal failure.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Dose-Response Relationship, Drug; Humans; Imidazoles; Imidazolidines; Kidney Failure, Chronic; Middle Aged; Prodrugs | 1998 |
23 other study(ies) available for imidaprilat and imidazolidines
| Article | Year |
|---|---|
Acute hemodynamic effects of the active metabolite of imidapril, (4S)-3-((2S)-2-[N-((1S)-1-carboxy-3-phenyl-propyl)amino]propionyl)-1- methyl-2-oxoimidazolidine-4-carboxylic acid, and enalaprilat in anesthetized dogs.
Topics: Anesthesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Dogs; Enalaprilat; Female; Heart; Hemodynamics; Imidazoles; Imidazolidines; Male; Myocardium; Oxygen Consumption; Regional Blood Flow; Vascular Resistance | 1992 |
Toxicodynamic analysis of cough and inflammatory reactions by angiotensin-converting enzyme inhibitors in guinea pig.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cough; Cyclooxygenase Inhibitors; Enalaprilat; Female; Guinea Pigs; Imidazoles; Imidazolidines; Indomethacin; Inflammation; Lisinopril | 1995 |
No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Chromatography, High Pressure Liquid; Decerebrate State; Electric Stimulation; Enalapril; Enalaprilat; Epinephrine; Hypertension; Imidazoles; Imidazolidines; Male; Norepinephrine; Rats; Rats, Inbred SHR; Spinal Cord; Sympathetic Nervous System; Vasopressins | 1993 |
Steady-state pharmacokinetics and pharmacodynamics of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Heart; Imidazoles; Imidazolidines; Male; Organ Size; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR | 1996 |
Pharmacokinetic and pharmacodynamic study of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor, in spontaneously hypertensive rats.
Topics: Administration, Oral; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Hypertension; Imidazoles; Imidazolidines; Infusions, Parenteral; Male; Radioimmunoassay; Rats; Rats, Inbred SHR | 1997 |
Effect of .OH scavenging action by non-SH-containing angiotensin converting enzyme inhibitor imidaprilat using microdialysis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Enalaprilat; Free Radical Scavengers; Hydroxyl Radical; Imidazoles; Imidazolidines; Male; Microdialysis; Molecular Structure; Rats; Rats, Wistar | 1998 |
Inhibition of angiotensin-converting enzyme increases the nitric oxide levels in canine ischemic myocardium.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Cilazapril; Coronary Circulation; Dogs; Imidazoles; Imidazolidines; Myocardial Ischemia; Nitric Oxide; Peptidyl-Dipeptidase A | 1998 |
Protective effect of imidaprilat, a new angiotensin-converting enzyme inhibitor against 1-methyl-4-phenylpyridinium ion-induced *OH generation in rat striatum.
Topics: 1-Methyl-4-phenylpyridinium; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Dopamine Agents; Hydroxyl Radical; Imidazoles; Imidazolidines; Male; Protective Agents; Rats; Rats, Wistar | 1999 |
Protective effect of imidaprilat, an angiotensin-converting enzyme inhibitor on *OH generation in rat myocardium.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrochemistry; Enalaprilat; Hydroxyl Radical; Imidazoles; Imidazolidines; Male; Myocardium; Rats; Rats, Wistar | 1999 |
Determination of imidapril and imidaprilat in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Angiotensin-Converting Enzyme Inhibitors; Chromatography, High Pressure Liquid; Humans; Imidazoles; Imidazolidines; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Protective effects of imidapril on He-Ne laser-induced thrombosis in cerebral blood vessels of stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arterioles; Cerebral Arteries; Drug Evaluation, Preclinical; Female; Genetic Predisposition to Disease; Hemorheology; Hypertension; Imidazoles; Imidazolidines; Intracranial Thrombosis; Lasers; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2000 |
Different inhibition of enalaprilat and imidaprilat on bradykinin metabolizing enzymes.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Dose-Response Relationship, Drug; Enalaprilat; Enzyme Inhibitors; Imidazoles; Imidazolidines; Lysine Carboxypeptidase; Male; Mice; Mice, Inbred ICR; Neprilysin | 2000 |
Comparison of the effect of imidaprilat and ramiprilat on broncho-constriction and hypotension induced by bradykinin in guinea pigs.
Topics: Angiotensin I; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Biphenyl Compounds; Blood Pressure; Bradykinin; Bronchoconstriction; Guinea Pigs; Imidazoles; Imidazolidines; Male; NG-Nitroarginine Methyl Ester; Piperidines; Ramipril | 2000 |
Imidaprilat suppresses nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum.
Topics: 1-Methyl-4-phenylpyridinium; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; Hydroxyl Radical; Imidazolidines; Male; Microdialysis; Phenols; Rats; Rats, Wistar | 2006 |
Angiotensin II directly inhibits protein synthesis in murine myotubes.
Topics: Angiotensin II; Animals; Drug Combinations; Imidazolidines; Insulin-Like Growth Factor I; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein Biosynthesis; Vasoconstrictor Agents | 2006 |
Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Benzhydryl Compounds; Corpus Striatum; Dopamine; Drug Interactions; Extracellular Space; Hydroxyl Radical; Imidazolidines; Male; Neuroprotective Agents; Phenols; Rats; Rats, Wistar; Time Factors | 2006 |
Angiotensin-converting enzyme inhibitor attenuates monocyte adhesion to vascular endothelium through modulation of intracellular zinc.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cell Adhesion; Cell Line; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Humans; Imidazolidines; Immunoblotting; Monocytes; Peptidyl-Dipeptidase A | 2007 |
Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1beta via NO-dependent pathway.
Topics: Analysis of Variance; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Imidazolidines; Interleukin-1beta; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Myocytes, Cardiac; Nitric Oxide; Probability; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA; Sensitivity and Specificity; Signal Transduction | 2008 |
Different inhibitory effects in rat and human carboxylesterases.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Camptothecin; Carboxylic Ester Hydrolases; Cytosol; Enzyme Inhibitors; Humans; Imidazolidines; In Vitro Techniques; Irinotecan; Jejunum; Liver; Microsomes, Liver; Pharmaceutical Preparations; Rats; Rats, Wistar; Species Specificity | 2009 |
Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes.
Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fumarates; Humans; Imidazolidines; Phosphorylation; Podocytes; Prorenin Receptor; Receptors, Cell Surface; Renin; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Tetrazoles | 2010 |
MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cell Line; Enzyme Activation; Foam Cells; Humans; Imidazolidines; Lipoproteins, LDL; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Monocytes; RNA, Small Interfering; Scavenger Receptors, Class A; Scavenger Receptors, Class E | 2010 |
Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Cytokines; Endothelial Cells; Hepatocyte Growth Factor; Humans; Imidazolidines; Indoles; Interleukin-10; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2011 |
Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Gene Knockout Techniques; Imidazolidines; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Receptor, Angiotensin, Type 1; Ultrasonography | 2013 |