imidaprilat has been researched along with imidapril in 12 studies
| Studies (imidaprilat) | Trials (imidaprilat) | Recent Studies (post-2010) (imidaprilat) | Studies (imidapril) | Trials (imidapril) | Recent Studies (post-2010) (imidapril) |
|---|---|---|---|---|---|
| 30 | 5 | 2 | 238 | 62 | 38 |
| Protein | Taxonomy | imidaprilat (IC50) | imidapril (IC50) |
|---|---|---|---|
| Angiotensin-converting enzyme | Homo sapiens (human) | 9.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, K; Ishida, R; Kato, J; Kubo, M; Nunami, K; Ochiai, T; Yoneda, N | 1 |
| Ikeo, T; Kaburaki, M; Kikkawa, K; Kurosawa, H; Murata, S; Narita, H; Yabana, H; Yamaguchi, I | 1 |
| Mizobe, M; Noda, K; Tagawa, K | 1 |
| Ishida, R; Ogiku, N; Sumikawa, H | 1 |
| Banno, K; Ishibashi, K; Ito, M; Mizobe, M; Morikawa, S; Murata, K; Sato, T; Suzuki, T; Takai, T; Yamanaka, K | 1 |
| Hoogkamer, JF; Kirch, W; Kleinbloesem, CH; Lankhaar, G; Nokhodian, A; Ouwerkerk, MJ; Ungethüm, W | 2 |
| Harder, S; Thürmann, PA | 1 |
| Banno, K; Murata, K; Sato, T; Takehara, N; Yamanaka, K | 1 |
| Fukuyama, T; Kano, Y; Kondo, T; Mabuchi, M | 1 |
| Giddings, JC; Noguchi, T; Sasaki, Y; Seki, J; Yamamoto, J | 1 |
| Jin, D; Li, ZL; Miyazaki, M; Otsuki, Y; Takai, S; Yamamoto, D | 1 |
5 trial(s) available for imidaprilat and imidapril
| Article | Year |
|---|---|
A saturable tissue-angiotensin I converting enzyme (ACE) binding model for the pharmacokinetic analysis of imidapril, a new ACE inhibitor, and its active metabolite in human.
Topics: Angiotensin-Converting Enzyme Inhibitors; Biological Availability; Half-Life; Humans; Imidazoles; Imidazolidines; Male; Peptidyl-Dipeptidase A; Regression Analysis | 1995 |
Radioimmunoassay for imidapril, a new angiotensin-converting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antibody Specificity; Chromatography, High Pressure Liquid; Cross Reactions; Humans; Imidazoles; Imidazolidines; Immunoconjugates; Indicators and Reagents; Male; Radioimmunoassay; Radioligand Assay | 1996 |
Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with impaired liver function.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Area Under Curve; Biotransformation; Half-Life; Humans; Imidazoles; Imidazolidines; Liver Diseases; Liver Function Tests | 1997 |
Pharmacokinetic and pharmacodynamic interaction trial after repeated oral doses of imidapril and digoxin in healthy volunteers.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Area Under Curve; Cross-Over Studies; Digoxin; Double-Blind Method; Drug Interactions; Half-Life; Humans; Imidazoles; Imidazolidines; Radioimmunoassay | 1997 |
Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with chronic renal failure.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Dose-Response Relationship, Drug; Humans; Imidazoles; Imidazolidines; Kidney Failure, Chronic; Middle Aged; Prodrugs | 1998 |
7 other study(ies) available for imidaprilat and imidapril
| Article | Year |
|---|---|
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Carboxylic Acids; Imidazoles; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Acute hemodynamic effects of the active metabolite of imidapril, (4S)-3-((2S)-2-[N-((1S)-1-carboxy-3-phenyl-propyl)amino]propionyl)-1- methyl-2-oxoimidazolidine-4-carboxylic acid, and enalaprilat in anesthetized dogs.
Topics: Anesthesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Dogs; Enalaprilat; Female; Heart; Hemodynamics; Imidazoles; Imidazolidines; Male; Myocardium; Oxygen Consumption; Regional Blood Flow; Vascular Resistance | 1992 |
No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Chromatography, High Pressure Liquid; Decerebrate State; Electric Stimulation; Enalapril; Enalaprilat; Epinephrine; Hypertension; Imidazoles; Imidazolidines; Male; Norepinephrine; Rats; Rats, Inbred SHR; Spinal Cord; Sympathetic Nervous System; Vasopressins | 1993 |
Pharmacokinetic and pharmacodynamic study of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor, in spontaneously hypertensive rats.
Topics: Administration, Oral; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Body Weight; Hypertension; Imidazoles; Imidazolidines; Infusions, Parenteral; Male; Radioimmunoassay; Rats; Rats, Inbred SHR | 1997 |
Determination of imidapril and imidaprilat in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Angiotensin-Converting Enzyme Inhibitors; Chromatography, High Pressure Liquid; Humans; Imidazoles; Imidazolidines; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Protective effects of imidapril on He-Ne laser-induced thrombosis in cerebral blood vessels of stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arterioles; Cerebral Arteries; Drug Evaluation, Preclinical; Female; Genetic Predisposition to Disease; Hemorheology; Hypertension; Imidazoles; Imidazolidines; Intracranial Thrombosis; Lasers; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2000 |
Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Gene Knockout Techniques; Imidazolidines; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Receptor, Angiotensin, Type 1; Ultrasonography | 2013 |