imetit and clobenpropit

imetit has been researched along with clobenpropit in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (15.38)18.2507
2000's18 (69.23)29.6817
2010's3 (11.54)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Christiaans, JA; Gynther, J; Kotisaari, S; Kovalainen, JT; Laitinen, JT; Männistö, PT; Tuomisto, L1
Chang, H; Erlander, MG; Lovenberg, TW; Pyati, J; Wilson, SJ1
Arrang, JM; Gbahou, F; Héron, A; Ligneau, X; Morisset, S; Sasse, A; Schwartz, JC; Tardivel-Lacombe, J1
Blevitt, J; Carruthers, N; Chai, W; Hofstra, CL; Jiang, X; Li, X; Liu, C; Lovenberg, TW; Ma, X; Pyati, J; Wilson, SJ1
Anthes, JC; Bayne, M; Behan, J; Gonsiorek, W; Greene, J; Greenfeder, SA; Gustafson, EL; Hedrick, JA; Hipkin, RW; Laz, TM; Monsma, FJ; Morse, KL; Qiao, X; Shin, N; Umland, S; Wan, Y; Wang, S; West, RE1
Audinot, V; Beauverger, P; Boutin, JA; Cogé, F; Galizzi, JP; Guénin, SP; Macia, C; Nagel, N; Ouvry, C; Renouard-Try, A; Rique, H1
Kuei, C; Liu, C; Lovenberg, TW; Wilson, SJ1
Bongers, G; Hashimoto, T; Leurs, R; Lovenberg, TW; Menge, WM; Timmerman, H; Wieland, K; Yamamoto, Y; Yamatodani, A1
Hastrup, S; Rimvall, K; Wulff, BS1
Chen, J; Liu, C; Lovenberg, TW1
Bakker, RA; Leurs, R; Lim, HD; Ling, P; Thurmond, RL; van Rijn, RM1
Falus, A; Jelinek, I; Keseru, GM; Kiss, B; Kiss, R; Könczöl, A; László, V; Noszál, B; Szalai, F1
Bakker, RA; de Esch, IJ; Gobbi, S; Haaksma, EE; Istyastono, EP; Jongejan, A; Lahaye, R; Leurs, R; Lim, HD; Menge, WM; Romeo, G; Schepers, M; Smits, RA; van de Stolpe, A; Zuiderveld, OP1
Ito, S; Mitobe, Y; Mizutani, T; Nagase, T; Sato, N; Tokita, S1
Handzlik, J; Kieć-Kononowicz, K; Kottke, T; Ligneau, X; Schunack, W; Seifert, R; Stark, H; Więcek, M1
de Esch, IJ; de Graaf, C; Istyastono, EP; Kooistra, AJ; Leurs, R; Lim, HD; Nijmeijer, S; Roumen, L; van de Stolpe, A; Vischer, HF1
Grätz, L; Humphrys, LJ; Işbilir, A; Lohse, MJ; Möller, J; Nagl, M; Pockes, S; Rosier, N; Schihada, H; Seibel, U1
Buczko, W; Godlewski, G; Malinowska, B; Schlicker, E1
Schlicker, E; Werthwein, S; Zentner, J1
Bacciottini, L; Bartolini, L; Blandina, P; Giovannini, MG; Greco, L1
Blanco, I; Gomez-Ramirez, J; Ortiz, J1
Brzozowski, T; Konturek, SJ; Obuchowicz, R; Pawlik, MW; Pawlik, WW1
Biernat, J; Brzozowski, T; Konturek, SJ; Obuchowicz, R; Pawlik, MW; Pawlik, WW; Sendur, R1
Blanks, AM; Lee, K; Renaud, LP; Spanswick, D; Whyment, AD1
Barrett, P; Ebling, FJ; Enright, RA; Jethwa, PH; Murphy, M; Turnbull, Y; Warner, A1
An, S; Chen, LY; Guo, XX; Hao, Q; Liu, Y; Ma, L; Pediani, JD; Tang, M; Ward, RJ; Wu, N; Xu, TR; Yang, Y; Zeng, H1

Other Studies

26 other study(ies) available for imetit and clobenpropit

ArticleYear
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.
    Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7

    Topics: Animals; Autoradiography; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Histamine Agonists; Histamine Antagonists; Imidazoles; In Vitro Techniques; Ligands; Male; Propylamines; Rats; Rats, Wistar; Receptors, Histamine H3; Stereoisomerism; Structure-Activity Relationship

1999
Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cloning, Molecular; Dose-Response Relationship, Drug; Humans; Methylhistamines; Molecular Sequence Data; Rats; Receptors, Histamine H3; Recombinant Proteins; RNA, Messenger

2000
The rat H3 receptor: gene organization and multiple isoforms.
    Biochemical and biophysical research communications, 2001, Jan-12, Volume: 280, Issue:1

    Topics: Animals; Autoradiography; Brain; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Frameshift Mutation; Genetic Variation; In Situ Hybridization; Introns; Iodine Radioisotopes; Organ Specificity; Protein Isoforms; Radioligand Assay; Rats; Receptors, Histamine H3; Recombinant Proteins; Sequence Deletion; Transcription, Genetic; Transfection

2001
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
    Molecular pharmacology, 2001, Volume: 59, Issue:3

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Bone Marrow; Cloning, Molecular; Histamine; Humans; Methylhistamines; Molecular Sequence Data; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; RNA, Messenger; Sequence Homology, Amino Acid; Tissue Distribution; Tritium

2001
Cloning and characterization of a novel human histamine receptor.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Amino Acid Sequence; Cells, Cultured; Cloning, Molecular; Histamine; Histamine Agonists; Humans; Imidazoles; Molecular Sequence Data; Radioligand Assay; Receptors, Histamine; Receptors, Histamine H3; RNA, Messenger; Sequence Homology, Amino Acid; Thiourea; Tissue Distribution; Transfection

2001
Genomic organization and characterization of splice variants of the human histamine H3 receptor.
    The Biochemical journal, 2001, Apr-15, Volume: 355, Issue:Pt 2

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Calcium; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Microscopy, Fluorescence; Molecular Sequence Data; Protein Binding; Receptors, Histamine H3; Sequence Homology, Amino Acid; Sulfur Radioisotopes

2001
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1

    Topics: Amino Acid Sequence; Animals; Calcium; Cell Line; Cloning, Molecular; COS Cells; Cyclic AMP; DNA Fragmentation; Guinea Pigs; Humans; Mice; Molecular Sequence Data; Radioligand Assay; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Transfection

2001
Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:3

    Topics: Animals; Burimamide; Cyclic AMP; Histamine Antagonists; Humans; Imidazoles; Male; Rats; Rats, Wistar; Receptors, Histamine H3; Recombinant Proteins; Thiourea; Tumor Cells, Cultured

2001
Characteristics of recombinantly expressed rat and human histamine H3 receptors.
    European journal of pharmacology, 2002, Oct-18, Volume: 453, Issue:1

    Topics: Animals; Cell Line; Cloning, Molecular; Histamine Agonists; Histamine Antagonists; Humans; Rats; Receptors, Histamine; Receptors, Histamine H3; Recombination, Genetic

2002
Molecular and pharmacological characterization of the mouse histamine H3 receptor.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Brain; Calcium; Cells, Cultured; Chlorocebus aethiops; Cloning, Molecular; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Humans; Imidazoles; Mice; Molecular Sequence Data; Rats; Receptors, Histamine H3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology; Thiourea

2003
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3

    Topics: Cell Line; Histamine Agonists; Humans; Imidazoles; Indoles; Isothiuronium; Ligands; Methylhistamines; Piperazines; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, Histamine H4

2005
Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening.
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Binding, Competitive; Cell Line, Tumor; Databases, Factual; Histamine Antagonists; Humans; Ligands; Models, Molecular; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Structure-Activity Relationship

2008
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
    Bioorganic & medicinal chemistry, 2009, Jun-01, Volume: 17, Issue:11

    Topics: Histamine H3 Antagonists; Humans; Imidazoles; Ligands; Male; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Thiourea

2009
Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.
    Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Chemistry, Pharmaceutical; Drug Design; Humans; Kinetics; Ligands; Mice; Models, Chemical; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine H3; Structure-Activity Relationship

2009
N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.
    Bioorganic & medicinal chemistry, 2011, May-01, Volume: 19, Issue:9

    Topics: Carbamates; Histamine Antagonists; Humans; Ligands; Phthalimides; Protein Isoforms; Receptors, Histamine H3

2011
Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
    Journal of medicinal chemistry, 2011, Dec-08, Volume: 54, Issue:23

    Topics: Cell Line, Tumor; Histamine Antagonists; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Quantitative Structure-Activity Relationship; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Stereoisomerism; Thiourea

2011
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H
    Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15

    Topics: Binding Sites; Bioluminescence Resonance Energy Transfer Techniques; Dose-Response Relationship, Drug; Fluorescent Dyes; HEK293 Cells; Histamine H3 Antagonists; Humans; Ligands; Molecular Structure; Receptors, Histamine H3; Single Molecule Imaging; Structure-Activity Relationship

2021
Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:2

    Topics: Adrenergic Fibers; Animals; Blood Pressure; Decerebrate State; Electric Stimulation; Histamine; Histamine Agonists; Histamine Antagonists; Hypertension; Imidazoles; Male; Methylhistamines; Piperidines; Pyrimethamine; Rats; Rats, Wistar; Receptors, Histamine H3; Thiourea; Vagotomy; Vascular Resistance

1997
Histamine H3 receptor-mediated inhibition of noradrenaline release in the human brain.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Dimethindene; Electric Stimulation; Hippocampus; Histamine; Histamine Agonists; Histamine Antagonists; Humans; Imidazoles; Male; Mice; Mice, Inbred Strains; Norepinephrine; Piperidines; Ranitidine; Receptors, Histamine H3; Thiourea; Tritium

1999
Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia.
    Behavioural brain research, 1999, Volume: 104, Issue:1-2

    Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cognition; Histamine Agonists; Histamine Antagonists; Imidazoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methylhistamines; Pattern Recognition, Visual; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H3; Scopolamine; Thiourea

1999
Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway.
    Molecular pharmacology, 2002, Volume: 61, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Bucladesine; Colforsin; Cyclic AMP; Drug Interactions; Histamine; Imidazoles; In Vitro Techniques; Male; Piperidines; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Thionucleotides; Thiourea

2002
Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Animals; Blood Pressure; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Imidazoles; Injections, Intra-Arterial; Injections, Intraventricular; Intestinal Mucosa; Intestines; Male; Microcirculation; Muscle, Smooth, Vascular; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Histamine H3; Splanchnic Circulation; Tachycardia; Thiourea; Time Factors; Vasoconstriction

2004
Histamine H3 receptors modulate reactive hyperemia in rat gut.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:3

    Topics: Animals; Blood Pressure; Female; Histamine Agonists; Histamine Antagonists; Hyperemia; Imidazoles; Infusions, Intra-Arterial; Intestinal Mucosa; Intestines; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Rats; Rats, Wistar; Receptors, Histamine H3; Regional Blood Flow; Thiourea

2004
Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors.
    Journal of neurophysiology, 2006, Volume: 95, Issue:4

    Topics: Action Potentials; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Barium; Dimaprit; Female; Ganglia, Sympathetic; Histamine; Histamine Agonists; Histamine H1 Antagonists; Imidazoles; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium; Rats; Rats, Inbred WKY; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiourea; Triprolidine

2006
The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.
    Behavioural pharmacology, 2009, Volume: 20, Issue:2

    Topics: Animals; Body Temperature; Cell Line, Transformed; Cricetinae; Disease Models, Animal; Eating; Histamine; Imidazoles; Injections, Intraventricular; Motor Activity; Obesity; Phodopus; Photoperiod; Piperidines; Receptors, Histamine H3; Seasons; Thiourea; Transfection

2009
Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology.
    The FEBS journal, 2018, Volume: 285, Issue:12

    Topics: Bacterial Proteins; Biosensing Techniques; Cyclic AMP; Fluorescence Resonance Energy Transfer; Gene Expression; Green Fluorescent Proteins; HEK293 Cells; Histamine; Histamine Agonists; Histamine H3 Antagonists; Humans; Imidazoles; Kinetics; Luminescent Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Plasmids; Receptors, Histamine H3; Thiourea; Transfection; Tritium

2018