iloprost and nileprost

Topics: Animals; Dexamethasone; Dinoprost; Dinoprostone; Epoprostenol; Female; Graft Survival; Granulocytes; Humans; Iloprost; Mice; Mice, Inbred C57BL; Prostaglandins; Skin Transplantation; Thromboxane B2; Thromboxanes

Prostaglandins and Prostaglandin-analogues were investigated for their ability to protect mice from platelet-activating factor (PAF) induced shock. 75% mortality in female NMRI mice was induced by i.v. injection of 75 micrograms/kg PAF. Nileprost and PGE1, the most potent substances, produced a dose dependent protection against PAF. Iloprost and PGI2 were less effective. PGE2, nalador, flunoprost and U 46619 were neither protective nor deleterious. The strong difference in the effectiveness between the two prostaglandins of the E-series and the poor effect of PGI2 and the PGI2 analogue is remarkable. Flunoprost and U 46619 that increased the TXB2 synthesis or release in two experimental models did not enhance the PAF mortality; TXA2 seems to be only a secondary mediator of the acute PAF-induced death.

Topics: Animals; Cell Survival; Epoprostenol; Female; Iloprost; Mice; Platelet Activating Factor; Prostaglandins; Prostaglandins, Synthetic; Shock

The preventive effects of nocloprost, nileprost, iloprost and (15S)-15-Methyl-prostaglandin E2 were studied in the rat gastric mucosal damage induced by restraint-cold stress, indomethacin and ethanol. Nocloprost was found to be the most potent orally active compound against rat mucosal damage induced by all noxious stimuli used in this study. Both nocloprost and iloprost were more effective on stress-induced ulcers than on those induced by indomethacin and ethanol. Nocloprost and 15-methyl prostaglandin E2 were also more active on ethanol-induced mucosal damage than on induced by indomethacin. No significant differences were obtained with iloprost and nileprost on indomethacin and ethanol-induced mucosal injury. These results indicate a more potent oral antiulcer activity of nocloprost.

Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Ethanol; Female; Gastric Mucosa; Iloprost; Indomethacin; Male; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Rats; Stress, Physiological

Iloprost (2 X 330 micrograms/kg sc./d) better than nalador (2 X 500 micrograms/kg sc./d) prolonged the average time until the complete rejection of murine tail skin allografts in inbred mice. Nileprost (2 X 500 micrograms/kg sc./d) showed a similar trend. The TXB2 content in the ambient skin at the transplantation site was significantly diminished by all three PG-analogues, but by nileprost more than by iloprost or nalador.

Topics: Animals; Cardiovascular Agents; Dinoprostone; Epoprostenol; Female; Graft Rejection; Iloprost; Mice; Mice, Inbred C57BL; Prostaglandins E, Synthetic; Reference Values; Skin; Skin Transplantation; Thromboxane B2; Transplantation, Homologous