ikp 104 and colchicine
ikp 104 has been researched along with colchicine in 5 studies
Compound Research Comparison
| Studies (ikp 104) | Trials (ikp 104) | Recent Studies (post-2010) (ikp 104) | Studies (colchicine) | Trials (colchicine) | Recent Studies (post-2010) (colchicine) |
|---|---|---|---|---|---|
| 9 | 0 | 0 | 15,472 | 404 | 2,974 |
Protein Interaction Comparison
| Protein | Taxonomy | ikp 104 (IC50) | colchicine (IC50) |
|---|---|---|---|
| Tubulin alpha-1A chain | Sus scrofa (pig) | 3.7639 | |
| Tubulin beta chain | Sus scrofa (pig) | 3.8663 | |
| Tubulin beta-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta chain | Homo sapiens (human) | 2.7244 | |
| Tubulin alpha-3C chain | Homo sapiens (human) | 2.4334 | |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | 4.3 | |
| Tubulin alpha-1B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-4B chain | Homo sapiens (human) | 2.4334 | |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | 2.62 | |
| Tubulin beta-3 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-8 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 2.8255 | |
| Tubulin alpha-3E chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-1A chain | Homo sapiens (human) | 2.4334 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.0611 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.1553 | |
| Tubulin alpha-1C chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-6 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-1 chain | Homo sapiens (human) | 2.4334 |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kitagaki, T; Mizuhashi, F; Murata, K; Tomita, I | 2 |
| Chaudhuri, AR; Luduena, RF; Mizuhashi, F; Murata, K; Prasad, V; Roach, MC; Tomita, I | 1 |
| Chaudhuri, AR; Curcio, M; Ludueña, RF; Mizuhashi, F; Murata, K; Prasad, V; Tomita, I | 1 |
| Chaudhuri, AR; Ludueña, RF; Mizuhashi, F; Murata, K; Potenziano, JL; Tomita, I | 1 |
Other Studies
5 other study(ies) available for ikp 104 and colchicine
| Article | Year |
|---|---|
Interaction of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, with microtubule proteins.
Topics: Animals; Colchicine; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Immunoblotting; Microscopy, Electron; Microtubule Proteins; Pyridones; Rats; Rats, Inbred Strains; Vinblastine | 1992 |
Effects of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, on cytoskeletal microtubules of cultured tumor cells.
Topics: Animals; Antineoplastic Agents; Colchicine; Cytoskeleton; Melanoma, Experimental; Mice; Microscopy, Electron; Microtubules; Mitosis; Pyridones; Tumor Cells, Cultured; Vinblastine | 1991 |
Interaction of bovine brain tubulin with the 4(1H)-pyrizinone derivative IKP104, an antimitotic drug with a complex set of effects on the conformational stability of the tubulin molecule.
Topics: Alkylation; Animals; Antineoplastic Agents; Brain; Carbon Radioisotopes; Cattle; Colchicine; Iodoacetamide; Mitosis; Protein Binding; Protein Conformation; Pyridones; Sulfhydryl Compounds; Tritium; Tubulin | 1995 |
Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay.
Topics: Alkylation; Animals; Antineoplastic Agents; Binding Sites; Cattle; Colchicine; Iodoacetamide; Nocodazole; Podophyllotoxin; Pyridones; Spectrometry, Fluorescence; Structure-Activity Relationship; Tubulin | 1998 |
IKP104-induced decay of tubulin: role of the A-ring binding site of colchicine.
Topics: Alkylation; Animals; Benzaldehydes; Binding Sites; Cattle; Colchicine; Protein Conformation; Pyridones; Spectrometry, Fluorescence; Tropolone; Tubulin; Tubulin Modulators | 1998 |