Page last updated: 2024-09-03

ikp 104 and colchicine

ikp 104 has been researched along with colchicine in 5 studies

Compound Research Comparison

Studies
(ikp 104)
Trials
(ikp 104)
Recent Studies (post-2010)
(ikp 104)
Studies
(colchicine)
Trials
(colchicine)
Recent Studies (post-2010) (colchicine)
90015,4724042,974

Protein Interaction Comparison

ProteinTaxonomyikp 104 (IC50)colchicine (IC50)
Tubulin alpha-1A chainSus scrofa (pig)3.7639
Tubulin beta chainSus scrofa (pig)3.8663
Tubulin beta-4A chainHomo sapiens (human)2.4334
Tubulin beta chainHomo sapiens (human)2.7244
Tubulin alpha-3C chainHomo sapiens (human)2.4334
Serine/threonine-protein kinase pim-1Homo sapiens (human)4.3
Tubulin alpha-1B chainHomo sapiens (human)2.4334
Tubulin alpha-4A chainHomo sapiens (human)2.4334
Tubulin beta-4B chainHomo sapiens (human)2.4334
Vesicular acetylcholine transporterTetronarce californica (Pacific electric ray)2.62
Tubulin beta-3 chainHomo sapiens (human)2.4334
Tubulin beta-2A chainHomo sapiens (human)2.4334
Tubulin beta-8 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainBos taurus (cattle)2.8255
Tubulin alpha-3E chainHomo sapiens (human)2.4334
Tubulin alpha-1A chainHomo sapiens (human)2.4334
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.0611
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)3.1553
Tubulin alpha-1C chainHomo sapiens (human)2.4334
Tubulin beta-6 chainHomo sapiens (human)2.4334
Tubulin beta-2B chainHomo sapiens (human)2.4334
Tubulin beta-1 chainHomo sapiens (human)2.4334

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kitagaki, T; Mizuhashi, F; Murata, K; Tomita, I2
Chaudhuri, AR; Luduena, RF; Mizuhashi, F; Murata, K; Prasad, V; Roach, MC; Tomita, I1
Chaudhuri, AR; Curcio, M; Ludueña, RF; Mizuhashi, F; Murata, K; Prasad, V; Tomita, I1
Chaudhuri, AR; Ludueña, RF; Mizuhashi, F; Murata, K; Potenziano, JL; Tomita, I1

Other Studies

5 other study(ies) available for ikp 104 and colchicine

ArticleYear
Interaction of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, with microtubule proteins.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:2

    Topics: Animals; Colchicine; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Immunoblotting; Microscopy, Electron; Microtubule Proteins; Pyridones; Rats; Rats, Inbred Strains; Vinblastine

1992
Effects of the tumor inhibitor IKP-104, a 4(1H)-pyridinone derivative, on cytoskeletal microtubules of cultured tumor cells.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:12

    Topics: Animals; Antineoplastic Agents; Colchicine; Cytoskeleton; Melanoma, Experimental; Mice; Microscopy, Electron; Microtubules; Mitosis; Pyridones; Tumor Cells, Cultured; Vinblastine

1991
Interaction of bovine brain tubulin with the 4(1H)-pyrizinone derivative IKP104, an antimitotic drug with a complex set of effects on the conformational stability of the tubulin molecule.
    Biochemistry, 1995, Dec-05, Volume: 34, Issue:48

    Topics: Alkylation; Animals; Antineoplastic Agents; Brain; Carbon Radioisotopes; Cattle; Colchicine; Iodoacetamide; Mitosis; Protein Binding; Protein Conformation; Pyridones; Sulfhydryl Compounds; Tritium; Tubulin

1995
Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay.
    Journal of protein chemistry, 1998, Volume: 17, Issue:7

    Topics: Alkylation; Animals; Antineoplastic Agents; Binding Sites; Cattle; Colchicine; Iodoacetamide; Nocodazole; Podophyllotoxin; Pyridones; Spectrometry, Fluorescence; Structure-Activity Relationship; Tubulin

1998
IKP104-induced decay of tubulin: role of the A-ring binding site of colchicine.
    Biochemistry, 1998, Dec-08, Volume: 37, Issue:49

    Topics: Alkylation; Animals; Benzaldehydes; Binding Sites; Cattle; Colchicine; Protein Conformation; Pyridones; Spectrometry, Fluorescence; Tropolone; Tubulin; Tubulin Modulators

1998