ifosfamide and trofosfamide

ifosfamide has been researched along with trofosfamide in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199017 (48.57)18.7374
1990's6 (17.14)18.2507
2000's10 (28.57)29.6817
2010's2 (5.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burckhardt, G; Flörl, S; Hagos, Y; Kühne, A; Marada, VV1
Brock, N; Pohl, J; Stekar, J2
Vogel, E1
Ellenberger, J; Mohn, GR1
Beijnen, JH; Bult, A; de Kraker, J; Kaijser, GP; Underberg, WJ; Wiese, G1
Brock, N; Pohl, J; Schneider, B1
Brock, N3
Masurel, D; Wainer, IW1
De Dominicis, G; De Marinis, E; Della Morte, R; Quinto, I; Staiano, N1
Belisario, MA; Della Morte, R; Mugnoz, B; Remondelli, P; Staiano, N1
Budzyński, W; Kinas, R; Kuśnierczyk, H; Misiura, K; Paprocka, M; Radzikowski, C; Rak, J; Stec, W1
Franz, G; Lietz, H1
Breuel, HP; Burkert, H; Lücker, PW; Wetzelsberger, N1
Adolphe, M; Deysson, G; Semont, H1
Adolphe, M; Deysson, G; Hecquet, C; Semont, H2
Harbers, E; Lindemann, H1
Schmid, SM; Struck, RF; Waud, WR1
Blaschke, G; Boos, J; Jürgens, H; Küpker, F1
Adler, ID; Ehling, UH; Favor, J; Neuhäuser-Klaus, A1
Acampora, A; Biglietto, M; Malorni, A; Miraglia, N; Sannolo, N1
Halme, M; Isokangas, OP; Joensuu, H; Mäntylä, M; Mattson, K; Pekonen, M; Pyrhönen, S; Ruotsalainen, T; Sarna, S1
Brinker, A; Brüggemann, SK; Kisro, J; Letsch, C; Wagner, T1
Finckenstein, FG; Graf, N; Gruhn, B; Hasan, C; Hero, B; Klingebiel, T; Koscielniak, E; Kremens, B; Laws, HJ; Niemeyer, C; Schulz, A; Selle, B; Wawer, A; Zintl, F1
Baumann, F; Niederwieser, D; Niemeyer, U; Pönisch, W; Preiss, R; Stefanovic, D1
Hartmann, JT; Kanz, L; Kopp, HG1
Bechrakis, NE; Coupland, SE; Fischer, L; Jahnke, K; Korfel, A; Thiel, E; Wagner, T; Willerding, G1
Bechrakis, NE; Coupland, SE; Jahnke, K; Komm, J; Korfel, A; Stein, H; Thiel, E1
Beck, JD; Bielack, S; Bölling, T; Dörr, HG; Jürgens, H; Klingebiel, T; Koscielniak, E; Langer, T; Paulides, M; Sauer, R; Stöhr, W; Willich, N1
Beske, F; Boos, J; Dantonello, T; Gadner, H; Hallmen, E; Int-Veen, C; Kazanowska, B; Klingebiel, T; Koscielniak, E; Marky, I; Treuner, J1
Bechrakis, NE; Fischer, L; Jahnke, K; Korfel, A; Kraemer, DF; Thiel, E; Willerding, G1
Deroussent, A; Giraud, B; Hebert, G; Paci, A; Vassal, G; Veal, GJ1

Reviews

3 review(s) available for ifosfamide and trofosfamide

ArticleYear
Genetic effects of cyclophosphamide, ifosfamide and trofosfamide.
    Mutation research, 1976, Volume: 32, Issue:3-4

    Topics: Animals; Chromosomes; Cyclophosphamide; Drosophila melanogaster; Escherichia coli; Genes, Dominant; Genes, Lethal; Humans; Ifosfamide; Mice; Mutagens; Mutation; Nitrogen Mustard Compounds; Oxazines; Plants; Recombination, Genetic; Saccharomyces cerevisiae; Salmonella typhimurium; Serratia marcescens; Translocation, Genetic

1976
Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.
    Cancer research, 1989, Jan-01, Volume: 49, Issue:1

    Topics: Cyclophosphamide; Humans; Ifosfamide; Mesna; Organ Specificity

1989
Oxazaphosphorines: new therapeutic strategies for an old class of drugs.
    Expert opinion on drug metabolism & toxicology, 2010, Volume: 6, Issue:8

    Topics: Animals; Antineoplastic Agents, Alkylating; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Drug Design; Genetic Therapy; Humans; Ifosfamide; Neoplasms

2010

Trials

5 trial(s) available for ifosfamide and trofosfamide

ArticleYear
[Results of the Hamburg ovarian blastoma study].
    Onkologie, 1985, Volume: 8, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Germany, West; Humans; Ifosfamide; Melphalan; Methotrexate; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Random Allocation; Tegafur; Vincristine

1985
Interferon-alpha and 13-cis-retinoic acid as maintenance therapy after high-dose combination chemotherapy with growth factor support for small cell lung cancer--a feasibility study.
    Anti-cancer drugs, 2000, Volume: 11, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Finland; Humans; Ifosfamide; Injections, Subcutaneous; Interferon-alpha; Isotretinoin; Lung Neoplasms; Male; Middle Aged

2000
New insights into the clinical pharmacokinetics of trofosfamide.
    International journal of clinical pharmacology and therapeutics, 2002, Volume: 40, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Biological Availability; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Middle Aged; Molecular Structure

2002
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cyclophosphamide; Eye Neoplasms; Female; Humans; Ifosfamide; Lymphoma; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Radiotherapy, Adjuvant; Retinal Neoplasms; Retrospective Studies; Surveys and Questionnaires; Survival Rate; Vitreous Body

2006
Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Epirubicin; Etoposide; Female; Humans; Idarubicin; Ifosfamide; Infant; Kaplan-Meier Estimate; Male; Melphalan; Sarcoma; Soft Tissue Neoplasms; Thiotepa; Treatment Outcome; Vincristine

2008

Other Studies

27 other study(ies) available for ifosfamide and trofosfamide

ArticleYear
Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Humans; Liver-Specific Organic Anion Transporter 1; Molecular Structure; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Peptides; Solute Carrier Organic Anion Transporter Family Member 1B3

2015
[Antidote against the urotoxic effects of the oxazaphorine derivatives cyclophosphamide, ifosfamide and trofosfamide].
    Die Naturwissenschaften, 1979, Volume: 66, Issue:1

    Topics: Animals; Antidotes; Carcinosarcoma; Cyclophosphamide; Ifosfamide; Mercaptoethanol; Mesna; Phosphoramide Mustards; Rats; Urine

1979
Mutagenic activity of cyclophosphamide, trofosfamide, and ifosfamide in drosophila melanogaster. specific induction of recessive lethals in the absence of detectable chromosome breakage.
    Mutation research, 1975, Volume: 33, Issue:2-3

    Topics: Animals; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Drosophila melanogaster; Genes, Dominant; Genes, Lethal; Genes, Recessive; Ifosfamide; Mutation; Nitrogen Mustard Compounds; Oxazines

1975
Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma.
    Journal of chromatography, 1991, Nov-15, Volume: 571, Issue:1-2

    Topics: Antineoplastic Agents; Child; Chromatography, Gas; Cyclophosphamide; Humans; Ifosfamide; Microchemistry

1991
Basic principles in preclinical cancer chemotherapy.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:5

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ifosfamide; Mechlorethamine; Mice; Neoplasms; Nitrogen Mustard Compounds; Rats

1990
Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma.
    Journal of chromatography, 1989, May-05, Volume: 490, Issue:1

    Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyclophosphamide; Humans; Ifosfamide; Stereoisomerism

1989
Induction of sperm abnormalities in mice by ifosfamide and trofosfamide.
    Mutation research, 1988, Volume: 201, Issue:1

    Topics: Animals; Cyclophosphamide; Epididymis; Ifosfamide; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Size; Sperm Count; Spermatozoa; Testis

1988
In vitro activation of isophosphamide and trophosphamide to metabolites mutagenic for bacteria.
    Toxicology letters, 1986, Volume: 31, Issue:3

    Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cyclophosphamide; Drug Interactions; Ifosfamide; Liver; Male; Methylcholanthrene; Monoamine Oxidase Inhibitors; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium

1986
Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates.
    Journal of immunopharmacology, 1986, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Evaluation, Preclinical; Female; Ifosfamide; Lethal Dose 50; Leukemia, Experimental; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Plasmacytoma; Stereoisomerism

1986
Ideas and reality in the development of cancer chemotherapeutic agents, with particular reference to oxazaphosphorine cytostatics.
    Journal of cancer research and clinical oncology, 1986, Volume: 111, Issue:1

    Topics: Alkylating Agents; Antineoplastic Agents; Biotransformation; Cyclophosphamide; Female; Humans; Ifosfamide; Inactivation, Metabolic; Male; Nitrogen Mustard Compounds; Prostatic Neoplasms; Structure-Activity Relationship; Sulfhydryl Compounds

1986
Bioavailability of orally administered mesna.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:11

    Topics: Administration, Oral; Adult; Antineoplastic Agents; Biological Availability; Cyclophosphamide; Humans; Ifosfamide; Injections, Intravenous; Male; Mercaptoethanol; Mesna

1984
[Comparative study of the antimitotic effects of cyclophosphamide, trofosfamide and ifosfamide on meristema plant cells and animal cells in in vitro culture].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1981, Volume: 175, Issue:2

    Topics: Animals; Cells, Cultured; Cricetinae; Cyclophosphamide; Fibroblasts; Ifosfamide; Kidney; Mitosis; Plant Cells

1981
The oxazaphosphorines.
    Cancer treatment reviews, 1983, Volume: 10 Suppl A

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Ifosfamide; Nitrogen Mustard Compounds; Structure-Activity Relationship

1983
Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds.
    Journal of cancer research and clinical oncology, 1981, Volume: 100, Issue:3

    Topics: Animals; Cyclophosphamide; Cystitis; Female; Ifosfamide; Kidney; Mercaptoethanol; Mesna; Rats; Urinary Bladder

1981
Effects of oxazaphosphorine cytostatics on granuloid progenitor cell (CFUc) proliferation in mice.
    Experimental hematology, 1982, Volume: 10, Issue:9

    Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Cyclophosphamide; Depression, Chemical; Granulocytes; Hematopoietic Stem Cells; Ifosfamide; Mice

1982
[Interaction of the three alkylating drugs, cyclophosphamide, ifosfamide and trofosfamide, with DNA and DNA-constituents in vitro (author's transl)].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:12

    Topics: Alkylating Agents; Animals; Cyclophosphamide; Deoxyribonucleosides; DNA Replication; Female; Ifosfamide; Microsomes, Liver; Rats

1980
Effect of three alkylating antimitotic agents and their metabolites on in vitro monogranulocytic colony forming cells from mouse bone marrow.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:3

    Topics: Alkylating Agents; Animals; Bone Marrow Cells; Cyclophosphamide; Granulocytes; Hematopoietic Stem Cells; Ifosfamide; Mice; Mitosis

1981
Antitumor activity of halogen analogs of phosphoramide, isophosphoramide, and triphosphoramide mustards, the cytotoxic metabolites of cyclophosphamide, ifosfamide, and trofosfamide.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:3

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Screening Assays, Antitumor; Humans; Ifosfamide; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphoramide Mustards; Tumor Cells, Cultured

1994
Trofosfamide metabolism in different species--ifosfamide is the predominant metabolite.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Cyclophosphamide; Female; Hydroxylation; Ifosfamide; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oxidation-Reduction; Rabbits; Rats; Rats, Sprague-Dawley

1993
Induction of specific-locus and dominant lethal mutations in male mice by ifosfamide (Holoxan).
    Genetical research, 1998, Volume: 72, Issue:3

    Topics: Animals; Cyclophosphamide; Genes, Dominant; Genes, Lethal; Germ Cells; Ifosfamide; Male; Mice; Mice, Inbred Strains; Mutagens; Mutation; Spermatozoa

1998
Determination of cyclophosphamide and ifosphamide in urine at trace levels by gas chromatography/tandem mass spectrometry.
    Journal of mass spectrometry : JMS, 1999, Volume: 34, Issue:8

    Topics: Cyclophosphamide; Gas Chromatography-Mass Spectrometry; Humans; Ifosfamide; Monitoring, Physiologic; Occupational Exposure; Sensitivity and Specificity

1999
High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.
    Bone marrow transplantation, 2002, Volume: 30, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Etoposide; Female; Germany; Hematologic Diseases; Humans; Ifosfamide; Infant; Kidney Diseases; Kidney Neoplasms; Life Tables; Lung Neoplasms; Male; Melphalan; Peripheral Blood Stem Cell Transplantation; Prognosis; Stomatitis; Survival Analysis; Thiotepa; Transplantation, Autologous; Wilms Tumor

2002
Investigations on the pharmacokinetics of trofosfamide and its metabolites-first report of 4-hydroxy-trofosfamide kinetics in humans.
    Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:6

    Topics: Administration, Oral; Aged; Antineoplastic Agents, Alkylating; Area Under Curve; Cyclophosphamide; Female; Humans; Ifosfamide; Lymphoproliferative Disorders; Male; Middle Aged

2004
Hypersensitivity pneumonitis associated with the use of trofosfamide.
    Anti-cancer drugs, 2004, Volume: 15, Issue:6

    Topics: Administration, Oral; Aged; Alveolitis, Extrinsic Allergic; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cystitis; Drug Administration Schedule; Female; Femur; Germany; Humans; Ifosfamide; Nausea; Neoplasm Metastasis; Nerve Sheath Neoplasms; Phosphoramide Mustards; Prednisolone; Pulmonary Fibrosis; Vomiting

2004
Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:12

    Topics: Aged; Antineoplastic Agents, Alkylating; Cyclophosphamide; Disease-Free Survival; Eye Neoplasms; Humans; Ifosfamide; Infusions, Intravenous; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Prospective Studies; Salvage Therapy

2005
Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System.
    Clinical endocrinology, 2007, Volume: 66, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Dactinomycin; Female; Follow-Up Studies; Humans; Ifosfamide; Incidence; Male; Multivariate Analysis; Sarcoma; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Vincristine

2007
Ifosfamide or trofosfamide in patients with intraocular lymphoma.
    Journal of neuro-oncology, 2009, Volume: 93, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Cyclophosphamide; Eye Neoplasms; Follow-Up Studies; Humans; Ifosfamide; Lymphoma; Middle Aged; Survival Analysis; Survivors; Time Factors; Vitrectomy

2009