ifosfamide and acetylcysteine

ifosfamide has been researched along with acetylcysteine in 34 studies

Research

Studies (34)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (38.24)	18.7374
1990's	5 (14.71)	18.2507
2000's	6 (17.65)	29.6817
2010's	9 (26.47)	24.3611
2020's	1 (2.94)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Einhorn, LH; Langefeld, C; Loehrer, PJ; Munshi, NC; Neuman, A; Nichols, CR; Roth, BJ; Sledge, G; Walsh, WB; Williams, SD	1
Ayele, W; Benvenuto, JA; Legha, SS; Newman, RA; Nicaise, C; Raber, MN	1
Einhorn, LH; Loehrer, PJ; Munshi, N; Williams, SD	1
Berenbaum, MC	1
Birch, R; Einhorn, LH; Greco, FA; Kramer, BS; Loehrer, PJ	1
Holoye, PY	1
Einhorn, LH; Loehrer, PJ; Wheeler, BM; Williams, SD	1
Einhorn, LH; Loehrer, PJ	1
Ansari, R; Einhorn, LH; Loehrer, PJ; Williams, SD	1
Saiers, JH; Slavik, M	2
Watson, RA	1
Gillen, LE; Holdiness, MR; Morgan, LR	1
Anderson, T; Duelge, J; Hansen, RM; Holoye, PY; Ritch, PS	1
Einhorn, LH; Loehrer, PJ; Williams, SD	1
Donley, PJ; Harrison, EF; Hunter, HL; Morgan, LR	2
Benjamin, RS; Legha, SS; Nicaise, C; Patel, SR	1
Aleksa, K; Chen, N; Koren, G; Rieder, M; Woodland, C	3
Chen, N; Hanly, L; Koren, G; Rieder, M	1
Aleksa, K; Bajcetic, M; Baw, B; Chen, N; Cutler, M; Freeman, D; Hanly, LN; Koren, G; Malkin, B; Palassery, R; Regueira, O; Rieder, MJ; Turner, C; Vasylyeva, TL	1
Chen, N; Hanly, L; Koren, G; Rieder, M; Yeger, H	1
Figueredo, R; Hanly, L; Koren, G; Koropatnick, J; Rieder, MJ	1
El-Desoky, KI; El-Sisi, Ael-D; El-Syaad, ME; Moussa, EA	1
Hanly, L; Huang, SH; Koren, G; Regueira, O; Rieder, MJ; Shah, RK; Vasylyeva, TL	1
Boskabadi, J; Salehifar, E; Yousefi-Mazhin, E	1

Reviews

4 review(s) available for ifosfamide and acetylcysteine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Single-agent ifosfamide studies in sarcomas of soft tissue and bone: the M.D. Anderson experience. Cancer chemotherapy and pharmacology, 1993, Volume: 31 Suppl 2 Topics: Acetylcysteine; Bone Neoplasms; Fluid Therapy; Humans; Ifosfamide; Mesna; Randomized Controlled Trials as Topic; Sarcoma; Soft Tissue Neoplasms; Treatment Outcome; Urinary Bladder Diseases	1993
Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2007,Summer, Volume: 14, Issue:2 Topics: Acetylcysteine; Humans; Ifosfamide; Kidney Diseases	2007
Ifosfamide nephrotoxicity in children: a mechanistic base for pharmacological prevention. Expert opinion on drug safety, 2009, Volume: 8, Issue:2 Topics: Acetaldehyde; Acetylcysteine; Age Factors; Antineoplastic Agents, Alkylating; Antioxidants; Child; Humans; Ifosfamide; Kidney Diseases; Oxidative Stress; Risk Factors	2009

Trials

5 trial(s) available for ifosfamide and acetylcysteine

Article	Year
Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial. Cancer treatment reports, 1986, Volume: 70, Issue:7 Topics: Acetylcysteine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Clinical Trials as Topic; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Middle Aged	1986
"Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial". Cancer treatment reports, 1987, Volume: 71, Issue:4 Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Ifosfamide; Lung Neoplasms	1987
Ifosfamide in refractory male germ cell tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:1 Topics: Acetylcysteine; Adult; Clinical Trials as Topic; Drug Administration Schedule; Dysgerminoma; Follow-Up Studies; Humans; Ifosfamide; Male; Testicular Neoplasms	1986
Protective effect of N-acetylcysteine on the urotoxicity produced by oxazaphosphorine without interference with anticancer activity. European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:1 Topics: Acetylcysteine; Antineoplastic Agents; Cyclophosphamide; Hematuria; Humans; Ifosfamide; Lung Neoplasms	1982
N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics. Journal of clinical pharmacology, 2012, Volume: 52, Issue:1 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Child; Drug Overdose; Female; Humans; Ifosfamide; Male; Protective Agents; Rats; Rats, Wistar	2012

Other Studies

25 other study(ies) available for ifosfamide and acetylcysteine

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Comparison of N-acetylcysteine and mesna as uroprotectors with ifosfamide combination chemotherapy in refractory germ cell tumors. Investigational new drugs, 1992, Volume: 10, Issue:3 Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dysgerminoma; Etoposide; Hematuria; Humans; Ifosfamide; Male; Mesna; Severity of Illness Index; Vinblastine	1992
Clinical pharmacokinetics of ifosfamide in combination with N-acetylcysteine. Anti-cancer drugs, 1992, Volume: 3, Issue:1 Topics: Acetylcysteine; Agranulocytosis; Bone Marrow; Humans; Ifosfamide; Sarcoma	1992
Cyclophosphamide and ifosfamide: role of uroprotective agents. Cancer investigation, 1990, Volume: 8, Issue:2 Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Hematuria; Humans; Ifosfamide; Mercaptoethanol; Mesna; Urogenital Neoplasms	1990
Direct search methods in the optimisation of cancer chemotherapy regimens. British journal of cancer, 1990, Volume: 61, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Evaluation; Female; Ifosfamide; Leucovorin; Leukemia L1210; Methotrexate; Mice; Time Factors	1990
Ifosfamide chemotherapy for pancreatic carcinoma. Cancer chemotherapy and pharmacology, 1986, Volume: 18 Suppl 2 Topics: Acetylcysteine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Ifosfamide; Infections; Leukopenia; Male; Middle Aged; Pancreatic Neoplasms; Thrombocytopenia; Urologic Diseases	1986
Ifosfamide: an active drug in the treatment of adenocarcinoma of the pancreas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:3 Topics: Acetylcysteine; Adenocarcinoma; Adult; Aged; Cyclophosphamide; Female; Humans; Ifosfamide; Male; Middle Aged; Pancreatic Neoplasms	1985
Pilot study of intravenous ifosfamide plus oral acetylcysteine in the treatment of non-small cell lung cancer. Veterinary and human toxicology, 1981, Volume: 23, Issue:Suppl 1 Topics: Acetylcysteine; Adenocarcinoma; Administration, Oral; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Ifosfamide; Infusions, Parenteral; Lung Neoplasms; Male; Pilot Projects	1981
Ifosfamide: chemotherapy with new promise and new problems for the urologist. Urology, 1984, Volume: 24, Issue:5 Topics: Acetylcysteine; Cyclophosphamide; Cystitis; Female; Hemorrhage; Humans; Ifosfamide; Kidney Neoplasms; Male; Testicular Neoplasms	1984
N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetates; Acetylcysteine; Biological Availability; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Ion Exchange; Cyclophosphamide; Drug Interactions; Humans; Ifosfamide; Kinetics; Lung Neoplasms; Time Factors	1983
Phase I clinical study of acetylcysteine's preventing ifosfamide-induced hematuria. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Lung Neoplasms	1983
Prophylaxis of ifosfamide toxicity with oral acetylcysteine. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetylcysteine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Kidney Diseases; Male; Middle Aged; Nausea; Neoplasms; Vomiting	1983
N-acetylcysteine and ifosfamide in the treatment of unresectable pancreatic adenocarcinoma and refractory testicular cancer. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetylcysteine; Adenocarcinoma; Adult; Aged; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Hematologic Diseases; Hematuria; Humans; Ifosfamide; Male; Middle Aged; Nervous System Diseases; Pancreatic Neoplasms; Testicular Neoplasms	1983
The control of ifosfamide-induced hematuria with N-acetylcysteine in patients with advanced carcinoma of the lung. Seminars in oncology, 1982, Volume: 9, Issue:4 Suppl 1 Topics: Acetylcysteine; Administration, Oral; Cyclophosphamide; Female; Hematuria; Humans; Ifosfamide; Lung Neoplasms; Male; Random Allocation	1982
The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. Translational research : the journal of laboratory and clinical medicine, 2007, Volume: 150, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Ifosfamide; In Vitro Techniques; Kidney Tubules, Proximal; Swine	2007
N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats. British journal of pharmacology, 2008, Volume: 153, Issue:7 Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; beta 2-Microglobulin; Creatinine; Disease Models, Animal; Free Radical Scavengers; Glutathione; Glutathione Transferase; Ifosfamide; Kidney Diseases; Lipid Peroxides; Magnesium; Male; Rats; Rats, Wistar; Severity of Illness Index	2008
The effect of N-acetylcysteine on the antitumor activity of ifosfamide. Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:5 Topics: Acetylcysteine; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Ifosfamide; Mesna; Neuroblastoma; Phosphoramide Mustards; Rhabdomyosarcoma	2011
The Effects of N-acetylcysteine on ifosfamide efficacy in a mouse xenograft model. Anticancer research, 2012, Volume: 32, Issue:9 Topics: Acetylcysteine; Animals; Antineoplastic Agents, Alkylating; Bone Neoplasms; Cell Growth Processes; Cell Line, Tumor; Drug Interactions; Female; Humans; Ifosfamide; Mice; Sarcoma, Ewing; Treatment Outcome; Xenograft Model Antitumor Assays	2012
Protective effects of alpha lipoic acid versus N-acetylcysteine on ifosfamide-induced nephrotoxicity. Toxicology and industrial health, 2015, Volume: 31, Issue:2 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Glutathione; Ifosfamide; Kidney; Lipid Peroxidation; Male; Nitric Oxide; Oxidative Stress; Rats; Thioctic Acid	2015
N-acetylcysteine rescue protocol for nephrotoxicity in children caused by ifosfamide. Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2013, Volume: 20, Issue:2 Topics: Acetylcysteine; Animals; Antidotes; Antineoplastic Agents, Alkylating; Antioxidants; Child; Drug Administration Schedule; Humans; Ifosfamide; Kidney Diseases; Neoplasms; Quality of Life	2013
Ifosfamide-induced acute kidney injury in a patient with leiomyosarcoma: A case report. Cancer reports (Hoboken, N.J.), 2022, Volume: 5, Issue:10 Topics: Acetylcysteine; Acute Kidney Injury; Creatinine; Female; Humans; Ifosfamide; Leiomyosarcoma; Mesna; Urea	2022