ifosfamide has been researched along with 4-hydroxyifosfamide in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Czownicki, Z; Misiura, K; Okruszek, A; Pankiewicz, K; Stec, WJ; Utracka, B | 1 |
| Cerny, T; Küpfer, A; Kurowski, V; Wagner, T | 1 |
| Arndt, CA; Balis, FM; Colvin, OM; McCully, CL; Poplack, DG | 1 |
| Amano, T; Ikeuchi, I | 1 |
| Borch, RF; Low, JE; Sladek, NE | 1 |
| Allenbacher, A; Botzler, C; Issels, RD; Meier, T; Multhoff, G; Wiesnet, M; Wilmanns, W | 1 |
| Kurowski, V; Wagner, T | 2 |
| McCain, DM; Struck, RF; Tendian, SW; Tillery, KH | 1 |
| Beijnen, JH; Bult, A; de Kraker, J; Kaijser, GP; Ter Riet, PG; Underberg, WJ | 1 |
| Brüggemann, SK; Kisro, J; Wagner, T | 1 |
| Beijnen, JH; de Kraker, J; Huitema, AD; Keizer, HJ; Kerbusch, T; Kettenes-van den Bosch, JJ; Ouwerkerk, J | 1 |
| Bousquet, B; Denis, SL; Gourmel, B; Granvil, CP; Wainer, IW | 1 |
| Fujita, K; Hirano, Y; Suzuki, K; Ushiyama, T | 1 |
| Boddy, AV; Griffin, MJ; Johnstone, EC; Lind, MJ | 1 |
| Beijnen, JH; Keizer, HJ; Kerbusch, T; Mathĵt, RA; Ouwerkerk, J; Rodenhuis, S; Schellens, JH | 1 |
| Brueggemann, SK; Deeken, M; Klich, S; Peters, SO; Schlenke, P; Wagner, T | 1 |
| Albrecht, H; Kiewe, P; Korfel, A; Neumann, M; Seyfert, S; Thiel, E; Wagner, T | 1 |
| Brendel, E; Broto, JM; Cubedo, R; del Muro, XG; Gallego, O; López-Pousa, A; Martín-Liberal, J; Tirado, OM | 1 |
| Bertrand, JR; Caron, J; Chapuis, H; Couvreur, P; Daville, A; Deroussent, A; Desmaele, D; Le Cam, E; Lesueur, LL; Martens, T; Paci, A; Pioche Durieu, C; Rivard, M; Skarbek, C; Vassal, G | 1 |
| Chapuis, H; Couvreur, P; Daudigeos-Dubus, E; Deroussent, A; Desmaële, D; Durand, S; Le Dret, L; Maury, A; Paci, A; Skarbek, C | 1 |
5 trial(s) available for ifosfamide and 4-hydroxyifosfamide
| Article | Year |
|---|---|
Metabolism and pharmacokinetics of oral and intravenous ifosfamide.
Topics: Acetaldehyde; Administration, Oral; Adult; Aged; Female; Humans; Ifosfamide; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1991 |
Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Mesna; Middle Aged | 1997 |
Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma.
Topics: Adult; Aged; Algorithms; Antineoplastic Agents, Alkylating; Cyclophosphamide; Female; Humans; Ifosfamide; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Sarcoma | 2001 |
Penetration of ifosfamide and its active metabolite 4-OH-ifosfamide into cerebrospinal fluid of patients with CNS malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Central Nervous System Neoplasms; Female; Humans; Ifosfamide; Infusions, Intravenous; Male; Middle Aged; Permeability | 2011 |
Phase I trial of sorafenib in combination with ifosfamide in patients with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cell Proliferation; Female; Humans; Ifosfamide; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; raf Kinases; Sarcoma; Sorafenib; Young Adult | 2014 |
16 other study(ies) available for ifosfamide and 4-hydroxyifosfamide
| Article | Year |
|---|---|
Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in the urine.
Topics: Cyclophosphamide; Humans; Ifosfamide; Magnetic Resonance Spectroscopy; Methods; Stereoisomerism | 1983 |
Cerebrospinal fluid penetration of active metabolites of cyclophosphamide and ifosfamide in rhesus monkeys.
Topics: Animals; Cyclophosphamide; Ifosfamide; Macaca mulatta; Male; Permeability | 1988 |
Fluorometric determination of 4-hydroxyifosfamide in blood and urine.
Topics: Animals; Drug Stability; Humans; Hydrogen-Ion Concentration; Ifosfamide; Rats; Spectrometry, Fluorescence | 1985 |
Further studies on the conversion of 4-hydroxyoxazaphosphorines to reactive mustards and acrolein in inorganic buffers.
Topics: Acrolein; Aldehydes; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Hydrogen-Ion Concentration; Ifosfamide; Kinetics; Nitrogen Mustard Compounds; Osmolar Concentration; Structure-Activity Relationship; Temperature | 1983 |
Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels.
Topics: Antibodies, Monoclonal; Antigens, CD; Buthionine Sulfoximine; CD3 Complex; Cells, Cultured; Cytotoxicity, Immunologic; Glutathione; Humans; Ifosfamide; Interleukin-2; Intracellular Fluid; Killer Cells, Natural; Lymphocyte Activation; Mesna; Methionine Sulfoximine; T-Lymphocytes, Cytotoxic | 1995 |
Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy.
Topics: Acetaldehyde; Adult; Aged; Carcinoma, Bronchogenic; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged | 1993 |
Quantification of 4-hydroxyifosfamide in plasma of ifosfamide-treated mice.
Topics: Animals; Antineoplastic Agents, Alkylating; Female; Ifosfamide; Male; Mice | 1997 |
Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.
Topics: Cerebellar Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Stability; Humans; Ifosfamide; Medulloblastoma; Reproducibility of Results; Sensitivity and Specificity | 1997 |
Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide.
Topics: Acetaldehyde; Carcinoma, Non-Small-Cell Lung; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ifosfamide; Kidney Tubules; Lung Neoplasms; Tumor Cells, Cultured | 1997 |
High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes.
Topics: Acetonitriles; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Erythrocytes; Humans; Ifosfamide; Indicators and Reagents; Mass Spectrometry; Semicarbazides; Sensitivity and Specificity | 1998 |
Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector.
Topics: Antineoplastic Agents, Alkylating; Chromatography, Gas; Humans; Ifosfamide; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity | 1999 |
Clinical application of an in vitro chemosensitivity test, the Histoculture Drug Response Assay, to urological cancers: wide distribution of inhibition rates in bladder cancer and renal cell cancer.
Topics: Antineoplastic Agents; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Ifosfamide; In Vitro Techniques; Kidney Neoplasms; Methotrexate; Urinary Bladder Neoplasms; Vinblastine | 1999 |
Ifosfamide metabolism and DNA damage in tumour and peripheral blood lymphocytes of breast cancer patients.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Comet Assay; DNA Damage; Doxorubicin; Female; Humans; Ifosfamide; Lymphocytes; Middle Aged; Time Factors; Tumor Cells, Cultured | 2000 |
Stem cell toxicity of oxazaphosphorine metabolites in comparison to their antileukemic activity.
Topics: Acetaldehyde; Alkylating Agents; Antineoplastic Agents; Cyclophosphamide; Drug Screening Assays, Antitumor; Hematopoietic Stem Cells; Humans; Ifosfamide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2002 |
Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Drug Design; Humans; Ifosfamide; Phosphoramide Mustards; Prodrugs | 2015 |
Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Ifosfamide; Linear Models; Mice; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2015 |