ifenprodil has been researched along with spermine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (58.97) | 18.2507 |
| 2000's | 11 (28.21) | 29.6817 |
| 2010's | 5 (12.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burnell, ES; Fang, G; Irvine, M; Jane, DE; Monaghan, DT; Sapkota, K | 1 |
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Abe, K; Chida, N; Saito, H | 1 |
| Cler, JA; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Ransom, RW | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Bagga, L; Derks, M; Doyle, KM; Purcell, WM | 1 |
| Williams, K | 1 |
| Baxter, K; Church, J; Fletcher, EJ; MacDonald, JF | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Baudry, M; Marvizón, JC | 1 |
| Carter, C; Nicolas, C | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Abe, K; Chida, N; Nishiyama, N; Saito, H | 1 |
| Atterwill, CK; Doyle, KM; Purcell, WM; Westgate, C | 1 |
| Chao, J; Fukuchi, J; Igarashi, K; Kashiwagi, K; Williams, K | 1 |
| Doyle, KM; Shaw, GG | 1 |
| Johnson, SW; Wu, YN | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Segal, JA; Skolnick, P | 1 |
| Kemp, JA; Kew, JN | 1 |
| Berger, ML; Rebernik, P | 1 |
| Fukuchi, J; Igarashi, K; Kashiwagi, K; Kuno, T; Masuko, T; Nguyen, ND; Pahk, AJ; Williams, K | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Mo, LL; Sundström, E | 1 |
| Arai, T; Haradahira, T; Hojo, J; Kida, T; Maeda, J; Maeda, M; Okauchi, T; Sasaki, S; Suhara, T; Suzuki, K; Yamamoto, F; Zhang, MR | 1 |
| D'Hooge, R; De Deyn, PP; Marescau, B; Van Bogaert, PP; Van de Vijver, G; Vanholder, R | 1 |
| Haradahira, T; Kurosaki, F; Maeda, J; Maeda, M; Okauchi, T; Sasaki, S; Suhara, T; Suzuki, K; Yamamoto, F | 1 |
| Kirby, BP; Shaw, GG | 1 |
| Dodd, PR; Lewis, RJ; Tsai, VW | 1 |
| Grant, GH; Huggins, DJ | 1 |
| Hirose, T; Igarashi, K; Jin, L; Kashiwagi, K; Miyazaki, M; Mizuno, S; Nishimura, K; Takigawa, M; Toida, T; Williams, K | 1 |
| Fukiwake, T; Füll, C; Han, X; Higashi, K; Igarashi, K; Kashiwagi, K; Leewanich, P; Mizuno, S; Nishimura, K; Terui, Y; Toida, T; Tomitori, H; Williams, K | 1 |
| Gavazzo, P; Guida, P; Marchetti, C; Zanardi, I | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Igarashi, K; Kashiwagi, K; Masuko, T; Mizuno, S; Nishimura, K; Saiki, R; Suganami, A; Tamura, Y; Toida, T; Tomitori, H; Williams, K; Yoshizawa, Y | 1 |
| Nowak, G; Poleszak, E; Serefko, A; Socała, K; Szewczyk, B; Wlaź, P; Wośko, S; Wróbel, A | 1 |
| Duarte, T; Frühauf, PK; Ineu, RP; Mello, CF; Rubin, MA; Tomazi, L | 1 |
1 review(s) available for ifenprodil and spermine
| Article | Year |
|---|---|
Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.
Topics: Allosteric Regulation; Benzenesulfonamides; Binding Sites; Cholesterol; Humans; Neurotransmitter Agents; Phenanthrenes; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides | 2019 |
38 other study(ies) available for ifenprodil and spermine
| Article | Year |
|---|---|
Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Amino Acids; Animals; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Female; Glutamates; Guinea Pigs; Hydrolysis; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperidines; Polyamines; Protein Kinase C; Receptors, Amino Acid; Receptors, Cell Surface; Spermine; Staurosporine | 1992 |
Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Cerebral Ventricles; Electric Stimulation; Evoked Potentials; Hippocampus; Injections, Intraventricular; Male; Piperidines; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Time Factors | 1992 |
Polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of cyclic GMP in the cerebellum.
Topics: Animals; Biogenic Polyamines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Injections, Intraventricular; Male; Methamphetamine; Mice; Neural Pathways; Ornithine; Pentylenetetrazole; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Polyamine and ifenprodil interactions with the NMDA receptor's glycine site.
Topics: Animals; Binding Sites; Drug Interactions; Glutamates; Glutamic Acid; Glycine; Male; Piperidines; Polyamines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Statistics as Topic | 1991 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?
Topics: Animals; Biguanides; Dizocilpine Maleate; Histamine Release; In Vitro Techniques; Kinetics; Mast Cells; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit.
Topics: Animals; Glutamic Acid; Glycine; Histamine; Oocytes; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus laevis | 1995 |
Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Excitatory Amino Acids; Fluorescent Dyes; Hippocampus; Mice; Patch-Clamp Techniques; Piperidines; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
[3H]dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-methyl-D-aspartate receptors.
Topics: Animals; Biguanides; Binding Sites; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Polyamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 1994 |
Autoradiographic distribution and characteristics of high- and low-affinity polyamine-sensitive [3H]ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Calmodulin; Hippocampus; Imidazoles; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sepharose; Spermidine; Spermine; Sulfonamides; Tissue Distribution; Trifluoperazine; Tritium | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Spermine promotes the survival of primary cultured brain neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Hippocampus; Neurons; Piperidines; Putrescine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1993 |
Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex.
Topics: Animals; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Histamine Release; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneum; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Thalamus | 1996 |
An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.
Topics: Amino Acid Sequence; Animals; Female; Hydrogen-Ion Concentration; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship; Xenopus | 1996 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotective Agents; Piperazines; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tremor | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Bacterial Agents; Carbohydrate Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kanamycin; Male; Molecular Sequence Data; Neomycin; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.
Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Brain; Cell Membrane; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Male; Neurons; Organ Specificity; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium; Zinc | 1999 |
A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Carrier Proteins; Excitatory Amino Acid Antagonists; Exons; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Piperidines; Protein Conformation; Protons; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA Splicing; Sequence Homology, Amino Acid; Spermine; Xenopus laevis | 1999 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex.
Topics: Animals; Biguanides; Cerebral Cortex; Dizocilpine Maleate; Hydrogen-Ion Concentration; Male; Neuroprotective Agents; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Tritium | 2001 |
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors.
Topics: Animals; Brain; Carbon Radioisotopes; Isotope Labeling; Macaca; Male; Metals; Mice; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Sensitivity and Specificity; Spermine; Tissue Distribution; Tomography, Emission-Computed; Whole-Body Counting | 2002 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channels; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Guanidines; Membrane Potentials; Mice; Neurons; Nickel; Piperidines; Potassium Channel Blockers; Seizures; Spermine; Spinal Cord; Succinates; Synapses; Tetraethylammonium; Tetrodotoxin; Uremia | 2003 |
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains.
Topics: Amines; Animals; Binding Sites; Brain; Butylamines; Carbon Radioisotopes; In Vitro Techniques; Injections, Intravenous; Isotope Labeling; Macaca mulatta; Male; Mice; Piperidines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tissue Distribution | 2004 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Motor Activity; Neurons; Neuroprotective Agents; Piperidines; Polyamines; Spermine; Time Factors | 2004 |
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor.
Topics: Alanine; Binding, Competitive; Cell Membrane; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine | 2005 |
The function of the amino terminal domain in NMDA receptor modulation.
Topics: Amino Acid Sequence; Binding Sites; Dimerization; Humans; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Spermine; Zinc | 2005 |
The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine.
Topics: Animals; Dose-Response Relationship, Drug; Mice; Mutagenesis, Site-Directed; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship | 2008 |
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor.
Topics: Aminoglycosides; Animals; Binding Sites; Biophysical Phenomena; Carbon Isotopes; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Time Factors; Tritium; Xenopus laevis | 2008 |
Molecular determinants of multiple effects of nickel on NMDA receptor channels.
Topics: Animals; Binding Sites; Biophysical Phenomena; Cell Line, Transformed; Dose-Response Relationship, Drug; Electric Stimulation; Glutamic Acid; Humans; Membrane Potentials; Models, Molecular; Nickel; Oocytes; Patch-Clamp Techniques; Piperidines; Point Mutation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Spermine; Trace Elements; Transfection; Xenopus; Zinc | 2009 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil.
Topics: Amino Acid Sequence; Animals; Female; Molecular Sequence Data; Piperidines; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Xenopus laevis | 2012 |
An anti-immobility effect of spermine in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermine; Swimming | 2014 |
Spermine reverses lipopolysaccharide-induced memory deficit in mice.
Topics: Analysis of Variance; Animals; Cytokines; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Exploratory Behavior; Lipopolysaccharides; Male; Memory Disorders; Mice; Piperidines; Recognition, Psychology; Spermine | 2015 |