ifenprodil has been researched along with ro 25-6981 in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Chimirri, A; Ciranna, L; Citraro, R; Costa, L; De Luca, L; De Sarro, G; Ferro, S; Gitto, R | 1 |
| Acher, FC; Bertrand, HO; Mony, L; Paoletti, P; Triballeau, N | 1 |
| Buemi, MR; Chimirri, A; Chisari, M; Ciranna, L; De Luca, L; De Sarro, G; Ferro, S; Gitto, R; Russo, E | 1 |
| Hawker, DD; Jansen Labby, K; Mataka, JJ; Silverman, RB; Trippier, PC | 1 |
| Burnell, ES; Fang, G; Irvine, M; Jane, DE; Monaghan, DT; Sapkota, K | 1 |
| Baumeister, S; Schepmann, D; Wünsch, B | 1 |
| Fischer, G; Heitz, MP; Kemp, JA; Kew, JN; Malherbe, P; Mohacsi, E; Mutel, V; Trube, G | 1 |
| Boyce, S; Hill, RG; Mason, G; O'Donnell, R; Rigby, M; Rupniak, NM; Sirinathsinghji, D; Webb, JK; Wyatt, A | 1 |
| Ito, I; Kawakami, R; Mishina, M; Sakimura, K; Sugiyama, H | 1 |
| Gallagher, MJ; Guttmann, RP; Kurapathi, S; Lynch, DR; Mutel, V; Seifert, KM; Shim, SS | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Chazot, PL | 1 |
| Auberson, YP; Lingenhoehl, K; Liu, L; Pozza, MF; Sheng, M; Wang, Y; Wang, YT; Wong, TP | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Gogas, KR | 1 |
| Evangelou, A; Kiortsis, DN; Konitsiotis, S; Tsironis, C | 1 |
| Baudry, M; Zhou, M | 1 |
| Bear, MF; Lu, W; Malenka, RC; Morishita, W; Nicoll, RA; Smith, GB | 1 |
| Bandyopadhyay, S; Hablitz, JJ | 1 |
| Ogata, M; Oh-Nishi, A; Saji, M; Satoh, SZ; Suzuki, N | 1 |
| Clark, JP; Kofuji, P | 1 |
| Albin, RL; Benton, K; Janiszewska, A; Ruprecht, L; Tallaksen-Greene, SJ | 1 |
| Egashira, N; Ikesue, H; Kawashiri, T; Mihara, Y; Oishi, R; Sada, H; Ushio, S; Yano, T | 1 |
| Li, YQ; Mei, XP; Wang, W; Wei, YY; Wu, SX; Xu, LX; Zhang, MM; Zhang, T | 1 |
| Li, YH; Wang, J; Zhang, G | 1 |
| Eipper, BA; Kiraly, DD; Lemtiri-Chlieh, F; Levine, ES; Mains, RE | 1 |
| Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK | 1 |
| Ahn, YJ; Cho, HY; Kim, J; Kim, Y; Yoon, YW | 1 |
| Brittain, JM; Brittain, MK; Brustovetsky, N; Brustovetsky, T; Cummins, TR; Khanna, R | 1 |
| Barksdale, D; Bausch, SB; Dong, Y; Galdzicki, Z; Rittase, WB | 1 |
| Li, Y; Li, YH; Wang, J; Zheng, L | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
4 review(s) available for ifenprodil and ro 25-6981
| Article | Year |
|---|---|
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Calcium Channels; Drug Combinations; Drug Design; Humans; Huntington Disease; Neurodegenerative Diseases; Nitric Oxide Synthase Type I; Oxidative Stress; Parkinson Disease; Protein Folding; Protein Structure, Quaternary; Proteostasis Deficiencies; Receptors, N-Methyl-D-Aspartate | 2013 |
Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.
Topics: Allosteric Regulation; Benzenesulfonamides; Binding Sites; Cholesterol; Humans; Neurotransmitter Agents; Phenanthrenes; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides | 2019 |
The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.
Topics: Animals; Binding Sites; Central Nervous System Diseases; Cognition; Drug Delivery Systems; Humans; Neuroprotective Agents; Phenols; Phosphorylation; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2004 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Huntington Disease; Pain; Phenols; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 2006 |
28 other study(ies) available for ifenprodil and ro 25-6981
| Article | Year |
|---|---|
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Binding Sites; Drug Design; Indoles; Membrane Potentials; Mice; Mice, Inbred DBA; Models, Molecular; Neurons; Patch-Clamp Techniques; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2009 |
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
Topics: Animals; Databases, Factual; Drug Design; Ligands; Models, Molecular; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus | 2010 |
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
Topics: Animals; Indoles; Ligands; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; X-Ray Diffraction | 2012 |
Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.
Topics: | 2019 |
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
Topics: Animals; Calcium Channels; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Phenols; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1997 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain Measurement; Phenols; Piperidines; Pyrrolidinones; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Triazines | 1999 |
Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses.
Topics: Animals; Cell Polarity; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phenols; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses | 2000 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Topics: Animals; Brain; Cell Line; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Kinetics; Mice; Mutation; Phenols; Piperidines; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine | 2001 |
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Phencyclidine; Phenols; Piperidines; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2003 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias.
Topics: Allosteric Regulation; Amantadine; Animals; Antipsychotic Agents; Dextrorphan; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Male; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.
Topics: Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia.
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Evoked Potentials; Neocortex; Patch-Clamp Techniques; Peptide Fragments; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2006 |
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus.
Topics: Analysis of Variance; Animals; Biophysics; Drug Combinations; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2009 |
Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2010 |
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; Kaplan-Meier Estimate; Male; Mice; Motor Activity; Organ Size; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Sex Factors; Treatment Outcome | 2010 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles; Male; Memantine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organoplatinum Compounds; Oxaliplatin; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 2011 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperalgesia; Indazoles; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; Neurons; Nitric Oxide Synthase Type I; Pain Measurement; Phenols; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord | 2011 |
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Long-Term Synaptic Depression; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Potentials; Visual Cortex; Zinc | 2011 |
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Cerebral Cortex; Disks Large Homolog 4 Protein; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Guanylate Kinases; Immunoprecipitation; In Vitro Techniques; Locomotion; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Patch-Clamp Techniques; Phenols; Piperidines; Protein Binding; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Transfection | 2011 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Male; Neuralgia; Pain Measurement; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries | 2012 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger | 2012 |
Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dynorphins; Memantine; Mossy Fibers, Hippocampal; Neuropeptide Y; Phenols; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Up-Regulation | 2014 |
Postsynaptic GluN2B-containing NMDA receptors contribute to long-term depression induction in medial vestibular nucleus neurons of juvenile rats.
Topics: Animals; Diazonium Compounds; Female; Long-Term Synaptic Depression; Phenols; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Sulfonamides; Vestibular Nuclei | 2020 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |