ifenprodil has been researched along with piperidines in 611 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (5.56) | 18.7374 |
| 1990's | 171 (27.99) | 18.2507 |
| 2000's | 218 (35.68) | 29.6817 |
| 2010's | 167 (27.33) | 24.3611 |
| 2020's | 21 (3.44) | 2.80 |
| Authors | Studies |
|---|---|
| Furukawa, T; Mitsuhiro, S; Nishikawa, M; Sakakibara, E; Yamashita, Y | 1 |
| Allen, J; Benavides, J; Peny, B; Scatton, B | 1 |
| Nicklas, WJ; Zeevalk, GD | 2 |
| Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA | 1 |
| Harms, J; Woodward, JJ | 1 |
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Furukawa, T; Mitsuhiro, S; Miyake, Y; Yamashita, Y | 1 |
| Darles, G; Graham, D; Langer, SZ | 1 |
| Britt, M; Paschetto, KA; Powel, RJ; Pullan, LM; Stumpo, RJ | 1 |
| Abe, K; Chida, N; Saito, H | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Ohkawara, A; Suzuki, T; Uchida, S; Yoneda, Y | 1 |
| Montastruc, JL; Rascol, A; Rascol, O; Senard, JM | 1 |
| Beart, PM; Conway, EL; Mercer, LD; Searle, AJ | 1 |
| Fukuta, T; Ishimaru, H; Kameyama, T; Katoh, A; Nabeshima, T; Suzuki, H | 1 |
| Borosky, SA; Clissold, DB; Ferkany, JW; Goode, S; Karbon, EW; Patch, RJ; Pontecorvo, MJ | 1 |
| Cler, JA; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 2 |
| Heikkila, RE; Riordan, DE; Sonsalla, PK | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Bakker, MH; Foster, AC | 1 |
| Butler, TW; Chenard, BL; Fox, CB; Koe, BK; Prochniak, MA; Ronau, RT; Schmidt, AW; Shalaby, IA | 1 |
| Ransom, RW | 1 |
| Legendre, P; Westbrook, GL | 1 |
| Millan, MJ | 1 |
| Bakker, MH; Foster, AC; McKernan, RM; Wong, EH | 1 |
| Beart, PM; Jarrott, B; Mercer, LD | 2 |
| Benavides, J; Dana, C; Scatton, B; Schoemaker, H | 1 |
| Arai, Y; Kinemuchi, H; Kisara, K; Nakazato, K; Oyama, K; Satoh, N; Tadano, T | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Bremer, ME; Contreras, PC; Gray, NM | 1 |
| Kato, H; Kurihara, J; Oda, N; Sahara, T; Tomita, H | 1 |
| Ferkany, JW; Karbon, EW; Patch, RJ; Pontecorvo, MJ | 1 |
| Allen, J; Langer, SZ; Schoemaker, H | 1 |
| Araki, T; Kogure, K; Nishioka, K | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| D'Angio, M; Scatton, B; Serrano, A | 1 |
| Jackson, A; Sanger, DJ | 3 |
| Carter, C; Rivy, JP; Scatton, B | 1 |
| Cler, J; Contreras, PC; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Benhamou, M; Kieny, R; Le Bas, P; Molkhou, JM; Natali, J | 1 |
| Goto, K; Hosoya, E; Suekawa, M | 1 |
| Honda, H; Salafsky, B; Shibuya, T | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Adeagbo, AS; Magbagbeola, AO | 1 |
| Honda, H; Sakai, Y | 1 |
| Kimura, Y; Nakase, H; Watanabe, K | 1 |
| Bando, K; Hatanaka, Y; Irino, O; Ohbayashi, S | 1 |
| Honda, H; Irino, O; Iwata, T; Izumisawa, M; Matsuda, H; Shibuya, T; Shimura, H; Tsuji, H; Watanabe, Y | 2 |
| Irino, O; Manabe, T; Saitoh, K | 1 |
| Honda, H; Irino, O; Shibuya, T; Shimura, H; Watanabe, Y | 1 |
| Bando, K; Honda, H; Irino, O; Saitoh, K; Uchida, M | 1 |
| Aburada, M; Goto, K; Hosoya, E; Suekawa, M | 1 |
| Honda, H; Irino, O; Manabe, T; Saitoh, K | 1 |
| Barale, F; Bourgeois, F; Costes, Y; Flicoteaux, H; Neidhardt, A; Pruniaux, T; Roullier, M | 1 |
| Hayashi, T; Irino, O; Ohkubo, K; Saitoh, K | 1 |
| Egawa, M; Hashimoto, N; Tobe, A | 1 |
| Izumi, N; Yasuda, H | 1 |
| Nagase, T; Sasa, M; Takaori, S | 1 |
| Chevalier, J; Hirsch, JL; Vallat, G | 1 |
| Hatano, M; Hoya, I; Ishihara, M; Miura, K; Miyata, K; Okusawa, S; Yamada, T; Yoshida, A | 1 |
| Kakihana, M; Nagaoka, A; Shibota, M | 1 |
| Bouloy, M; Boussard, JF; Edvinsson, L; MacKenzie, ET; Young, AR | 1 |
| Furukawa, T; Maeda, Y; Nishikawa, M; Sakakibara, E; Yamashita, Y | 1 |
| Kerby, J; Laughton, P; Le Bourdellés, B; Myers, J; Priestley, T; Whiting, PJ | 1 |
| Bagga, L; Derks, M; Doyle, KM; Purcell, WM | 1 |
| Lovinger, DM; McCool, BA | 1 |
| Beart, PM; Frandsen, A; Schousboe, A | 1 |
| Lovinger, DM | 2 |
| Hashimoto, K; London, ED; Scheffel, U | 1 |
| Bordner, J; Butler, TW; Chambers, LK; Chenard, BL; Collins, MA; De Costa, DL; Ducat, MF; Dumont, ML; Fox, CB; Mena, EE | 1 |
| Goldstone, AD; Lu, CY; Sahgal, S; Trout, JJ | 1 |
| Nordholm, L; Sheardown, MJ; Suzdak, PD | 1 |
| Doyle, KM; Shaw, GG | 2 |
| Audinat, E; Crépel, F; Lambolez, B; Rossier, J | 1 |
| Williams, K | 3 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Hashimoto, K; London, ED | 2 |
| Branchereau, A; Rouffy, J | 1 |
| Kemp, JA; Ochu, E; Priestley, T | 1 |
| Carrozza, DP; Molinoff, PB; Pritchett, DB; Williams, K; Zhong, J | 1 |
| Baxter, K; Church, J; Fletcher, EJ; MacDonald, JF | 1 |
| Beart, PM; Jarrott, B; Mercer, LD; Ryan, MC; Wong, MG | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, WA; Zarnowski, T | 1 |
| Anegawa, NJ; Dichter, M; Lawrence, JJ; Lenz, S; Lynch, DR; Pritchett, DB | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Hashimoto, K; London, ED; Mantione, CR; Neumeyer, JL; Spada, MR | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Baudry, M; Marvizón, JC | 1 |
| Carter, C; Nicolas, C | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| De Sarro, A; De Sarro, GB | 1 |
| Kornhuber, J; Riederer, P | 1 |
| Akaike, A; Sasa, M; Sato, Y; Takaori, S; Tamura, Y; Yokota, T | 1 |
| Bernardi, M; Bertolini, A; Genedani, S | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Bailliart, O; Caillard, P; Cloarec, M; Mouren, X | 1 |
| Molinoff, PB; Russell, SL; Shen, YM; Williams, K | 1 |
| Abe, K; Chida, N; Nishiyama, N; Saito, H | 1 |
| Brave, S; French, D; Geter-Douglass, B; Witkin, JM | 1 |
| Arai, Y; Kinemuchi, H; Kisara, K; Oyama, K; Tadano, T; Togashi, M; Yonezawa, A | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR; Pritchett, DB | 1 |
| Lu, L; Luo, J; McGonigle, P; Munir, M; Wang, YH; Wolfe, BB | 1 |
| Atterwill, CK; Doyle, KM; Purcell, WM; Westgate, C | 1 |
| Chao, J; Fukuchi, J; Igarashi, K; Kashiwagi, K; Williams, K | 1 |
| Breese, GR; Criswell, HE; Moy, S; Simson, P; Yang, X | 1 |
| Chavez-Noriega, L; Crona, J; Daggett, LP; Deal, C; Ellis, SB; Hess, SD; Johnson, EC; Lu, CC; Urrutia, A; Veliçelebi, G | 1 |
| Avenet, P; Besnard, F; Depoortere, H; Frost, J; Graham, D; Langer, SZ; Léonardon, J; Scatton, B | 1 |
| Aulakh, CS; Mazzola-Pomietto, P; Murphy, DL | 1 |
| Bernardi, M; Bertolini, A; Genedani, S; Szczawinska, K | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Macaulay, AJ; Ochu, E; Priestley, T | 1 |
| Bath, CP; Bleakman, D; Farrell, LN; Gilmore, J; Hicks, CA; O'Neill, MJ; Ward, MA | 1 |
| Johnson, SW; Wu, YN | 1 |
| Carter, C; Fage, D; Klarica, M; Nankai, M | 1 |
| Basile, AS; Berlin, C; Huang, JM; Skolnick, P; Webster, D; Xie, C | 1 |
| Kirson, ED; Yaari, Y | 1 |
| Cooke, MJ; Fisher, A; Fraser, CM; Stone, TW; Thompson, ID | 1 |
| Bermoser, K; Glossmann, H; Hanner, M; Moebius, FF; Reiter, RJ | 1 |
| Kemp, JA; Kew, JN; Trube, G | 2 |
| Başkaya, MK; Dempsey, RJ; Donaldson, D; Prasad, MR; Rao, AM | 1 |
| Cordon, JJ; Coughenour, LL | 1 |
| Geng, MY; Nishiyama, N; Saito, H | 1 |
| Blevins, T; Mirshahi, T; Woodward, JJ | 1 |
| Gisselmann, G; Gottmann, K; Hatt, H; Mehrle, A | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 4 |
| Pahk, AJ; Williams, K | 1 |
| Glossmann, H; Hanner, M; Moebius, FF; Reiter, RJ | 1 |
| Orchinik, M; Tanapat, P; Weiland, NG | 1 |
| Barbour, MJ; Bolton, C; Paul, C; Scott, GS; Seiler, N | 1 |
| Eraković, V; Mrsić, J; Simonić, A; Varljen, J; Zupan, G | 1 |
| Montastruc, JL; Rascol, O; Senard, JM | 1 |
| Ilyin, VI; Whittemore, ER; Woodward, RM | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Prusky, G; Ramoa, AS | 1 |
| De Jong, GI; Harkány, T; Leonard, BE; Noonan, D; Nyakas, C; O'Mahony, S | 1 |
| Akerman, KE; Courtney, MJ; Engblom, AC; Kukkonen, JP | 1 |
| Blevins, T; Chandler, LJ; Mirshahi, T; Woodward, JJ | 1 |
| Başkaya, MK; Dempsey, RJ; Doğan, A; Donaldson, D; Rao, AM; Rao, VL; Rastl, J | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Fischer, G; Heitz, MP; Kemp, JA; Kew, JN; Malherbe, P; Mohacsi, E; Mutel, V; Trube, G | 1 |
| Ruppersberg, JP | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Kemp, JA; Kew, JN; Mutel, V; Richards, JG | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Gottmann, K; Hatt, H; Lindlbauer, R; Mohrmann, R | 1 |
| Abrahám, I; De Jong, GI; Harkany, T; Leonard, BE; Luiten, PG; Nyakas, C; O'Mahony, S; Penke, B; Rensink, AA; Varga, JL; Zarándi, M | 1 |
| Badolo, L; Dubois, J; Hanocq, M; Helson-Cambier, M | 1 |
| Caudle, RM; Dubner, R | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR | 1 |
| McIntosh, TK; Okiyama, K; Smith, DH; White, WF | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Reggiani, A; Tomasini, MC; Trist, DG | 1 |
| Dichter, MA; Kendrick, SJ; Wilcox, KS | 1 |
| Segal, JA; Skolnick, P | 1 |
| Sussman, H; Virag, R | 1 |
| Ganguly, A; Keefe, KA | 1 |
| Aizenman, E; Brimecombe, JC; Gallagher, MJ; Lynch, DR | 1 |
| Kemp, JA; Kew, JN | 1 |
| Bermoser, K; Cho, SY; Glossmann, H; Moebius, FF; Paik, YK; Reiter, RJ | 1 |
| Barann, M; Bönisch, H; Göthert, M; Urban, BW | 1 |
| Lecasble, M; Marquis, P; Passa, P | 1 |
| Gruol, DL; Netzeband, JG; Qiu, Z; Sweeney, DD | 1 |
| Adams, AC; Keefe, KA | 1 |
| Doyle, KM; Eddleston, A; Feerick, S; Higgins, GA; Kirkby, DL | 1 |
| Bonn, G; Fiechtner, B; Glossmann, H; Huck, CW; Moebius, FF; Soellner, KE | 1 |
| Brotchie, JM; Hill, MP; Nash, JE | 1 |
| Allgaier, C; Feuerstein, TJ; Illes, P; Müller, D; Scheibler, P | 1 |
| Anders, DL; Blevins, T; Chandler, LJ; Sutton, G; Woodward, JJ | 1 |
| Currás, MC; Dao, J; Gillard, ER; Goel, RK; Jamal, FA; Khan, AM; Stanley, BG; Turkowski, CA; Wolfsohn, SD | 1 |
| Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L | 1 |
| Dingledine, R; Doherty, JJ; Fendley, MJ; Lyuboslavsky, P; Mott, DD; Traynelis, SF; Washburn, MS; Zhang, S | 1 |
| Murali, SG; Sun, D | 1 |
| Bear, MF; Huganir, RL; Philpot, BD; Quinlan, EM | 1 |
| Bhave, SV; Hoffman, PL; Snell, LD; Tabakoff, B | 1 |
| Deakin, JF; Grimwood, S; Hutson, PH; Slater, P | 1 |
| Kato, H; Misawa, M; Suzuki, H; Suzuki, T; Tsuda, M | 1 |
| Chenard, BL; Menniti, FS | 1 |
| Tovar, KR; Westbrook, GL | 2 |
| Basham, ME; Nordeen, EJ; Nordeen, KW; Singh, TD; Sohrabji, F | 1 |
| Lickteig, RL; Lovinger, DM; Popp, RL | 1 |
| Berger, ML; Rebernik, P | 1 |
| Boyce, S; Hill, RG; Mason, G; O'Donnell, R; Rigby, M; Rupniak, NM; Sirinathsinghji, D; Webb, JK; Wyatt, A | 1 |
| Fukuchi, J; Igarashi, K; Kashiwagi, K; Kuno, T; Masuko, T; Nguyen, ND; Pahk, AJ; Williams, K | 1 |
| Meyerhoff, JL; Repasi, RT; Rittase, WB; Staten, LD; Yourick, DL | 1 |
| Sharif, NA; Xu, SX | 2 |
| Buczko, W; Göthert, M; Malinowska, B; Napiórkowska-Pawlak, D; Pawlak, R | 1 |
| Bousquet, P; Feldman, J; Lienhard, JP; Monassier, L; Riehl, V; Tibiriça, E | 1 |
| Bönisch, H; Brüss, M; Göthert, M; Molderings, GJ | 1 |
| Kirson, ED; Konnerth, A; Schirra, C; Yaari, Y | 1 |
| Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS | 1 |
| DeFazio, RA; Hablitz, JJ | 2 |
| Andreas, K; Häntzschel, A | 1 |
| Momiyama, A | 1 |
| Ito, I; Kawakami, R; Mishina, M; Sakimura, K; Sugiyama, H | 1 |
| Brickley, SG; Cull-Candy, SG; Farrant, M; Misra, C | 1 |
| Ahlemeyer, B; Hoffmann, GF; Kölker, S; Krieglstein, J | 2 |
| Höfner, G; Wanner, KT | 1 |
| Meltzer, LT; Schelkun, RM; Serpa, K; Whittemore, ER; Wise, LD; Woodward, RM; Yuen, PW | 1 |
| Gottmann, K; Hatt, H; Mohrmann, R | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM; Premkumar, LS | 1 |
| Araie, M; Matsubara, M; Muta, K; Tamaki, Y | 2 |
| Hironaka, N; Niki, H | 1 |
| Mizoguchi, H; Narita, M; Soma, M; Suzuki, T; Tseng, LF | 1 |
| Healy, DJ; Hogg, AJ; Ibrahim, HM; Meador-Woodruff, JH | 1 |
| Cathala, L; Cull-Candy, S; Misra, C | 1 |
| Başkaya, MK; Dempsey, RJ; Doğan, A | 1 |
| Brotchie, JM; Crossman, AR; Fox, SH; Henry, B; Hill, MP; Hille, C; Maneuf, Y; McGuire, S; Nash, JE; Peggs, D | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
| Adams, AC; Keefe, KA; Layer, RT; McCabe, RT | 1 |
| Kolb, JE; Levine, ES | 1 |
| Grimwood, S; Harrison, N; Hutson, PH; Murray, F; Richards, P; Wingrove, PB | 1 |
| Constantine-Paton, M; Shi, J; Townsend, M | 1 |
| Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H | 1 |
| Barr, BM; Coughenour, LL | 1 |
| Akaike, A; Honda, Y; Kaneda, K; Kashii, S; Kikuchi, M; Sato, S; Yasuyoshi, H; Zhang, S | 1 |
| Bieńkowski, P; Koroś, E; Kostowski, W; Kukwa, A; Scińska, A | 1 |
| Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Shi, WX; Zhang, XX | 1 |
| Gallagher, MJ; Guttmann, RP; Kurapathi, S; Lynch, DR; Mutel, V; Seifert, KM; Shim, SS | 1 |
| Meador-Woodruff, JH; Ritter, LM; Unis, AS | 1 |
| Kee, N; Snyder, JS; Wojtowicz, JM | 1 |
| Bousquet, P; Brandt, CM; Monassier, L | 1 |
| Aoki, K; Narita, M; Nomura, M; Suzuki, T; Yoshizawa, K | 1 |
| Mo, LL; Sundström, E | 1 |
| LeDoux, JE; Rodrigues, SM; Schafe, GE | 1 |
| Banke, T; Conn, PJ; Erreger, K; Lee, CJ; Low, CM; Traynelis, SF; Zheng, F | 1 |
| Gordey, M; Mekmanee, L; Mody, I | 1 |
| Gavazzo, P; Gazzoli, A; Marchetti, C; Mazzolini, M | 1 |
| Kazuta, Y; Kohsaka, S; Kudo, Y; Matsuda, A; Mishina, M; Nakajima-Iijima, S; Nakamura, T; Shuto, S; Uchino, S; Watanabe, W | 1 |
| Cunningham, MO; Evans, DI; Jones, RS; Woodhall, G | 1 |
| Liu, X; Onaka, T; Yagi, K | 1 |
| Lu, SM; Yeh, HH; Zecevic, N | 1 |
| Crair, MC; Gonzalez, E; Lu, HC | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Hashizume, T; Numata, H | 1 |
| Gibb, AJ; Green, GM | 1 |
| Lei, S; McBain, CJ | 1 |
| Bading, H; Fukunaga, Y; Hardingham, GE | 1 |
| Joshi, I; Wang, LY | 1 |
| Gibb, AJ; Piña-Crespo, JC | 1 |
| Hendricson, AW; Lippmann, MJ; Miao, CL; Morrisett, RA | 1 |
| Bauer, EP; LeDoux, JE; Schafe, GE | 1 |
| Arai, T; Haradahira, T; Hojo, J; Kida, T; Maeda, J; Maeda, M; Okauchi, T; Sasaki, S; Suhara, T; Suzuki, K; Yamamoto, F; Zhang, MR | 1 |
| Bobkiewicz-Kozlowska, T; Mikolajczak, P; Okulicz-Kozaryn, I; Polanska, A; Szczawinska, K | 1 |
| Gottmann, K; Hatt, H; Köhr, G; Mohrmann, R; Sprengel, R | 1 |
| Brotchie, JM; Nash, JE | 1 |
| Neyton, J; Paoletti, P; Perin-Dureau, F; Rachline, J | 1 |
| Cebere, A; Cebers, G; Liljequist, S; Wägner, A | 1 |
| Feldmeyer, D; Lübke, J; Radnikow, G | 1 |
| Gebka, J; Kaminska, E; Mikolajczak, P; Niedopad, L; Okulicz-Kozaryn, I; Polanska, A | 1 |
| Chen, N; Li, B; Luo, T; Murphy, TH; Otsu, Y; Raymond, LA | 1 |
| Dave, JR; Ling, G; Lu, XM; Tortella, FC; Williams, AJ | 1 |
| Breese, GR; Criswell, HE; Griffith, BL; Ming, Z; Mueller, RA | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Gibson, DA; Harris, BR; Littleton, JM; Rogers, DT | 1 |
| Blanchard, JA; Gibson, DA; Harris, BR; Holley, RC; Littleton, J; Mayer, S; Prendergast, MA | 1 |
| Kojima, N; Kume, N; Obata, K; Stork, O; Stork, S | 1 |
| Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z | 1 |
| Guilarte, TR; Hashemzadeh-Gargari, H; McGlothan, JL; Toscano, CD | 1 |
| Breese, GR; Criswell, HE; Griffith, BL; Ming, Z | 1 |
| Chapman, DE; Keefe, KA; Wilcox, KS | 1 |
| Dunn, RJ; Harvey-Girard, E | 1 |
| Fu, Z; Losi, G; Luo, J; Prybylowski, K; Vicini, S; Wenthold, RJ | 1 |
| D'Hooge, R; De Deyn, PP; Marescau, B; Van Bogaert, PP; Van de Vijver, G; Vanholder, R | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shibata, H; Takenaka, C | 1 |
| Baimbridge, KG; Fernandes, HB; Krebs, C; Raymond, LA; Sheldon, C | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Buddenberg, T; De Souza Silva, MA; Dere, E; Fink, H; Huston, JP; Topic, B | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Brickley, SG; Cull-Candy, SG; Mishina, M; Misra, C; Mok, MH | 1 |
| Dave, JR; Koenig, ML; Moffett, JR; Tortella, FC; Williams, AJ | 1 |
| Morrison, LD; Richter, A | 1 |
| Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM | 1 |
| Bristow, LJ; Clarke, HF; Grimwood, S; Guscott, MR; Hutson, PH; Murray, F | 1 |
| Floyd, DW; Jung, KY; McCool, BA | 1 |
| Alhonen, L; Gröhn, OH; Jänne, J; Kaasinen, SK; Keinänen, TA | 1 |
| Gallagher, JP; Liu, J; McKernan, MG; Russell, RT; Shinnick-Gallagher, P; Xie, J; Zinebi, F | 1 |
| Dineley, KT; Galvan, CD; Lam, TT; Schwartzkroin, PA; Swann, JW; Sweatt, JD; Wenzel, JH | 1 |
| Camarini, R; Janak, PH; Ron, D; Tang, KC; Yaka, R | 1 |
| Besret, L; Bottlaender, M; Bramoullé, Y; Coulon, C; Dollé, F; Kassiou, M; Lagnel, B; Ottaviani, M; Roger, G; Valette, H | 1 |
| Honse, Y; Leslie, SW; Randall, PK | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Chazot, PL | 1 |
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| Hashimoto, K | 1 |
| Bird, CW; Candelaria-Cook, FT; Davies, S; Hamilton, DA; Magcalas, CM; Savage, DD; Valenzuela, CF | 1 |
| Galvin, C; Lee, FS; Ninan, I | 1 |
| Bai, Y; Chao, J; Dong, J; Lv, X; Shen, K; Yao, H; Zhang, Y; Zhu, X | 1 |
| Antic, SD; Oikonomou, KD; Rich, MT; Short, SM; Singh, MB | 1 |
| Jang, HJ; Joo, K; Kim, MJ; Lee, C; Rhie, DJ | 1 |
| Berger, ML; Boykin, DW; Huang, TL; Ismail, MA; Jarak, I; Karminski-Zamola, G; Kaźmierczak, P; Kumar, A; Maciejewska, D; Mayence, A; Mottamal, M; Piantanida, I; Rebernik, P; Rezler, M; Vanden Eynde, JJ; Żabiński, J | 1 |
| Jayaraman, V; MacLean, DM; Sirrieh, RE | 1 |
| Cao, ZJ; Chen, SL; Chen, X; Fang, JY; Feng, CC; Li, WT; Liu, Q; Wang, EM; Yan, XJ | 1 |
| Dick, ALW; Duncan, JR; Gibbs, S; Giles, E; Lawrence, AJ; Pooters, T; Qama, A | 1 |
| Smothers, CT; Szumlinski, KK; Woodward, JJ; Worley, PF | 1 |
| Becker, D; Fontana, A; Habbas, S; Klaus, FR; Kollias, G; Liaudet, N; Pryce, CR; Santello, M; Stubbe, H; Suter, T; Volterra, A; Zappia, G | 1 |
| Dey, S; Schepmann, D; Wünsch, B | 1 |
| Buhl, DL; Chanda, PK; Green, M; Knafels, JD; Mony, L; Pandit, J; Paoletti, P; Sciabola, S; Stroebel, D | 1 |
| Chen, YW; Chiu, CC; Hung, CH; Wang, JJ; Wang, JN | 1 |
| Alvares, Lde O; Crestani, AP; Hardt, O; Lunardi, P; Pedraza, LK; Quillfeldt, JA; Sachser, RM; Santana, F | 1 |
| Bernard, P; Bizot, JC; David, S; Puech, A; Tassin, JP; Trovero, F | 1 |
| Diaz-Avalos, R; Furukawa, H; Grant, T; Grigorieff, N; Karakas, E; Simorowski, N; Tajima, N | 1 |
| Chen, B; Chen, Z; Feng, B; Hou, W; Hu, W; Tang, Y; Wang, Y; You, Y | 1 |
| Plested, AJ | 1 |
| Chen, G; Li, L; Li, T; Liu, X; Qiao, C | 1 |
| Alfei, JM; Bueno, AM; Cuadra, G; Ferrer Monti, RI; Giachero, M; Molina, VA | 1 |
| Chen, G; Hou, Y; Li, L; Li, T; Liu, X; Qian, H; Qiao, C | 1 |
| Tian, M; Ye, S | 1 |
| Gunkel, BT; Hughes, MN; Prior, NA; Rogers, KK; Yates, JR | 1 |
| Chen, Z; Feng, H; Liu, Z; Wang, G; Zhao, X | 1 |
| DePoy, LM; Gourley, SL; Marvar, PJ; Zimmermann, KS | 1 |
| Barto, D; Bird, CW; Davies, S; Donaldson, T; Hamilton, DA; Magcalas, CM; Rodriguez, CI; Savage, DD | 1 |
| Furukawa, H; Karakas, E; Romero-Hernandez, A; Simorowski, N | 1 |
| Cheng, B; Huang, Y; Li, D; Liu, G; Shen, W; Su, J; Zhang, YX; Zhou, WX | 1 |
| Meng, ZY; Wang, FX; Xiong, XY; Yang, H; Yang, QW; Zhong, Q | 1 |
| Freeman, JH; Ng, KH; Steinmetz, AB | 1 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Bankstahl, M; Brandt, C; Bröer, S; Gerhauser, I; Klee, R; Li, D; Löscher, W; Meller, S; Rankovic, V; Römermann, K; Schidlitzki, A; Töllner, K; Twele, F; Waltl, I | 1 |
| Buisson, A; Nicole, O; Perrio, C | 1 |
| Chen, L; Huang, M; Jiang, B; Li, S; Li, Y; Wang, L; Wang, X; Yang, Y; Zhang, X | 1 |
| Abbasova, K; Kubová, H; Mareš, P | 1 |
| Chen, D; Chen, Y; Li, R; Liu, Y; Song, Z; Wang, Y; Xia, M; Yang, K; Yang, L; Yu, H; Zhang, LW; Zhang, X; Zhao, J | 1 |
| Huang, Y; Li, S; Qin, J; Shen, L; Wang, W | 1 |
| Aikawa, Y; Haraguchi, A; Ikeda, K; Ogai, Y; Sugaya, N; Takahama, M; Tanaka, M; Umeno, M; Yumoto, Y | 1 |
| Chen, J; Chen, K; Lai, Y; Lin, F; Sun, K; Wang, B; Yu, Y; Zhou, X; Zou, T | 1 |
| Delpire, E; Fairbanks, CA; Goracke-Postle, CJ; Peterson, CD; Séguéla, P; Verma, H; Waataja, JJ; Wilcox, GL | 1 |
| Cline, HT; Faulkner, RL; Gambrill, AC; McKeown, CR | 1 |
| Hasegawa, S; Hida, H; Mishina, M; Mouri, A; Nabeshima, T; Noda, Y; Ozaki, N; Uchida, Y; Yamada, K; Yoshimi, A | 1 |
| Abd Aziz, CB; Haris, K; Ismail, CAN; Long, I; Suppian, R | 1 |
| Funada, D; Ikeda, K; Kotajima-Murakami, H; Maruo, K; Matsumoto, T; Murakami, M; Ogai, Y; Sasaki, T; Tachimori, H; Takano, A; Tanibuchi, Y; Tsukamoto, S | 1 |
| Arga, KY; Benfeitas, R; Kim, W; Mardinoglu, A; Turanli, B; Uhlen, M; Zhang, C | 1 |
| Ametamey, SM; Börgel, F; Galla, F; Lehmkuhl, K; Schepmann, D; Wünsch, B | 1 |
| Dannenhoffer, CA; Spear, LP | 1 |
| Foster, TC; Kumar, A; Thinschmidt, JS | 1 |
| Agato, Y; Asai, T; Fukuta, T; Ishii, T; Kikuchi, T; Koide, H; Oku, N; Shimizu, K; Yanagida, Y | 1 |
| Li, Y; Li, YH; Wang, J; Zheng, L | 1 |
| Chen, G; Chen, T; Li, T; Liu, X; Qian, H; Qiao, C; Shang, Q; Wang, J; Xiao, J; Zhang, P | 1 |
| Fang, Y; Ju, P; Liu, H; Niu, Z; Wu, X; Yao, Y; Zhang, C; Zhu, Y | 1 |
| Ikeda, K; Kotajima-Murakami, H | 1 |
| Foster Olive, M; Gipson, CD; Leyrer-Jackson, JM; McCallum, J; Piña, JA | 1 |
| Ab Aziz, CB; Ismail, CAN; Long, I; Suppian, R | 1 |
| Bertoglio, LJ; Troyner, F | 1 |
| Álvarez, I; Bechthold, E; Bernal, FA; Daniliuc, C; Frehland, B; Garcia, CV; Lehmkuhl, K; Schepmann, D; Schmidt, TJ; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Dai, Q; Dong, M; Hu, J; Liu, Z; Mao, W; Prorok, M; Su, R; Yu, S; Yu, Z; Zhu, C | 1 |
| Amiad, L; Azriel, M; Bingor, A; Yaka, R | 1 |
| Dannenhoffer, CA; Spear, LP; Varlinskaya, EI; Werner, DF | 1 |
| Korff, M; Markus, A; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Hou, YJ; Mi, QJ; Ni, QB; Sun, BL; Sun, JY; Wang, HB; Yang, MF; Yuan, H; Zhang, ZY; Zhao, SJ | 1 |
| Arnold, AC; Browning, KN; Clyburn, C; Travagli, RA | 1 |
| Lecca, S; Mameli, M; Mondoloni, S; Nuno-Perez, A; Tchenio, A | 1 |
| Ferrara, NC; Helmstetter, FJ; Pullins, SE; Trask, S | 1 |
| Chen, P; Chen, Z; Liao, H; Liu, W; Pan, Y; Sheng, T; Xie, J; Yao, H; Zhang, Q; Zhou, H; Zou, Z | 1 |
| Chan, BKC; Cheung, MSH; Choi, GCG; Chu, HY; Fong, JHC; Huang, Y; Ma, S; Mak, KH; Pardeshi, L; Tong, CSW; Tong, M; Wong, ASL; Wong, KH; Wong, TL; Xu, F | 1 |
| Ban, E; Funada, D; Hirakawa, S; Ikeda, K; Kawashima, T; Kikuchi, M; Kotajima-Murakami, H; Maruo, K; Matsumoto, T; Ogai, Y; Oi, H; Sasaki, T; Tachimori, H; Takano, A; Tanibuchi, Y; Tomo, Y | 1 |
| Hanaoka, H; Hashimoto, K; Hashimoto, T; Hosoda, Y; Iyo, M; Kanahara, N; Kawasaki, Y; Niitsu, T; Oda, Y; Ozawa, Y; Sasaki, T; Shiina, A; Shiko, Y; Sugawara, T; Suzuki, T | 1 |
| Buyukuysal, RL; Gul, Z; Gursoy, M | 1 |
18 review(s) available for ifenprodil and piperidines
| Article | Year |
|---|---|
Glutamate antagonists and Parkinson's disease: a review of clinical data.
Topics: Antiparkinson Agents; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; Parkinson Disease; Piperidines; Receptors, Glutamate | 1997 |
Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.
Topics: Aging; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1998 |
Antagonists selective for NMDA receptors containing the NR2B subunit.
Topics: Excitatory Amino Acid Antagonists; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Substrate Specificity | 1999 |
[Ototoxic mechanism of aminoglycoside antibiotics--role of glutaminergic NMDA receptors].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium; Calcium Channel Blockers; Cochlea; Deafness; Excitatory Amino Acid Antagonists; Hair Cells, Auditory; Humans; Piperidines; Receptors, N-Methyl-D-Aspartate | 2000 |
Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Piperidines; Receptors, N-Methyl-D-Aspartate | 2001 |
The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.
Topics: Animals; Binding Sites; Central Nervous System Diseases; Cognition; Drug Delivery Systems; Humans; Neuroprotective Agents; Phenols; Phosphorylation; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2004 |
Amino terminal domain regulation of NMDA receptor function.
Topics: Animals; Binding Sites; Humans; Ligands; Oxidation-Reduction; Piperidines; Polyamines; Protein Structure, Tertiary; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Zinc | 2004 |
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamate; Glutamic Acid; Humans; Neuroprotective Agents; Phenylcarbamates; Piperidines; Propylene Glycols; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens.
Topics: Animals; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Intracellular Signaling Peptides and Proteins; Ketamine; Membrane Proteins; Mice; Morphine Dependence; Nucleus Accumbens; Piperidines; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2005 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Huntington Disease; Pain; Phenols; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 2006 |
NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2006 |
[Nicergoline, ibudilast, ifenprodil tartrate].
Topics: Animals; Cerebral Infarction; Humans; Nicergoline; Piperidines; Pyridines; Vasodilator Agents | 2006 |
[Treatment by medicine which improves cerebral circulation and metabolism].
Topics: Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Humans; Nicergoline; Piperidines; Pyridines; Vasodilator Agents | 2006 |
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential.
Topics: Allosteric Regulation; Allosteric Site; Animals; Brain Diseases; Depressive Disorder, Major; Humans; Magnesium; Neurotransmitter Agents; Pain; Piperidines; Polyamines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Zinc | 2009 |
Molecular structure of ionotropic glutamate receptors.
Topics: Animals; Binding Sites; Drug Design; Excitatory Amino Acid Antagonists; Humans; Models, Molecular; Piperidines; Protein Structure, Tertiary; Receptors, Ionotropic Glutamate | 2010 |
Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication.
Topics: Animals; Donepezil; Humans; Indans; Mental Disorders; Models, Neurological; Neurotransmitter Agents; Piperidines; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor | 2015 |
Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.
Topics: Animals; Bacteria; Benzothiadiazines; Cognition; Cysteine Loop Ligand-Gated Ion Channel Receptors; Gene Expression; Humans; Ion Channel Gating; Ion Channels; Ivermectin; Locomotion; Models, Molecular; Neurotransmitter Agents; Perception; Piperidines; Receptors, Glutamate; Synapses; Synaptic Transmission | 2016 |
[Clinical study of GIRK channel inhibitors as candidate medicines for drug dependence].
Topics: Amphetamine-Related Disorders; Animals; Clinical Trials as Topic; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Japan; Methamphetamine; Neurons; Piperidines; Reward; Substance-Related Disorders | 2020 |
10 trial(s) available for ifenprodil and piperidines
| Article | Year |
|---|---|
[Ifenprodil tartrate in the treatment of occlusive arteriopathies of the lower limbs. Results of a prospective double-blind controlled multicenter trial].
Topics: Arterial Occlusive Diseases; Double-Blind Method; Female; Humans; Leg; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Prospective Studies; Random Allocation; Vasodilator Agents | 1989 |
[Double-blind randomized controlled trial of ifenprodil tartrate versus placebo in chronic arterial occlusive disease of the legs at stage II of the Leriche and Fontaine classification].
Topics: Aged; Arterial Occlusive Diseases; Chronic Disease; Double-Blind Method; Female; Humans; Leg; Male; Middle Aged; Piperidines; Placebos; Vasodilator Agents | 1995 |
Evaluation of ifenprodil efficacy on exercise-induced tissue ischemia in stage II arteriopathy by measurement of transcutaneous oxygen tension during a standard treadmill test: double-blind study of injectable ifenprodil versus placebo.
Topics: Blood Gas Monitoring, Transcutaneous; Double-Blind Method; Female; Humans; Injections, Intramuscular; Ischemia; Leg; Male; Middle Aged; Oxygen; Physical Exertion; Piperidines; Vasodilator Agents | 1993 |
[Quality of life of patient with peripheral arterial obliterative disease treated with ifenprodil tartrate. Results of an ARTEMIS study].
Topics: Aged; Arterial Occlusive Diseases; Female; Humans; Male; Piperidines; Prospective Studies; Quality of Life; Regional Blood Flow; Time Factors; Vasodilator Agents | 1998 |
Effects of centrally-acting glutamatergic modulators on cardiovascular responses to stress in humans.
Topics: Administration, Oral; Adult; Baclofen; Cold Temperature; Double-Blind Method; Excitatory Amino Acid Antagonists; Exercise Test; GABA Agonists; Heart Rate; Hemodynamics; Humans; Intelligence Tests; Piperidines; Stress, Physiological | 2001 |
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.
Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Magnesium; Membrane Potentials; N-Methylaspartate; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Reference Values | 2004 |
A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Male; Middle Aged; Piperidines; Potassium Channel Blockers | 2018 |
Study of effects of ifenprodil in patients with methamphetamine dependence: Protocol for an exploratory, randomized, double-blind, placebo-controlled trial.
Topics: Adult; Amphetamine-Related Disorders; Double-Blind Method; Female; Humans; Male; Methamphetamine; Off-Label Use; Piperidines; Potassium Channel Blockers; Treatment Outcome | 2019 |
Ifenprodil for the treatment of methamphetamine use disorder: An exploratory, randomized, double-blind, placebo-controlled trial.
Topics: Central Nervous System Stimulants; Double-Blind Method; Humans; Methamphetamine; Piperidines | 2022 |
Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial.
Topics: Adolescent; Double-Blind Method; Humans; Piperidines; Stress Disorders, Post-Traumatic; Treatment Outcome | 2022 |
583 other study(ies) available for ifenprodil and piperidines
| Article | Year |
|---|---|
Effect of ifenprodil on mitochondrial respiration of guinea pig brain.
Topics: Animals; Brain; Electron Transport Complex IV; Guinea Pigs; In Vitro Techniques; Male; Mersalyl; Mitochondria; Oligomycins; Oxygen Consumption; Phosphorus Acids; Piperidines; Potassium Cyanide | 1979 |
Pharmacological characterization of in vivo [3H]lfenprodil binding sites in the mouse brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Drug Interactions; Kinetics; Male; Mice; Piperidines; Psychotropic Drugs; Radioligand Assay; Receptors, Opioid; Receptors, sigma | 1992 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Excitatory amino acid-induced phosphoinositide turnover in guinea pig cerebral cortical slices: selective enhancement by spermine of the response to DL-1-aminocyclopentane-trans-1,3-dicarboxylate.
Topics: Adrenergic alpha-Antagonists; Alkaloids; Amino Acids; Animals; Calcium; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Female; Glutamates; Guinea Pigs; Hydrolysis; Male; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperidines; Polyamines; Protein Kinase C; Receptors, Amino Acid; Receptors, Cell Surface; Spermine; Staurosporine | 1992 |
[Effects of ifenprodil on the adenosine triphosphatase of guinea pig liver mitochondria].
Topics: Adenosine Triphosphatases; Adrenergic alpha-Antagonists; Animals; Dinitrophenols; Dose-Response Relationship, Drug; Guinea Pigs; Hot Temperature; In Vitro Techniques; Magnesium; Male; Mitochondria, Liver; Piperidines; Potassium; Sodium; Vasodilator Agents | 1992 |
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Biguanides; Magnesium; Male; Neomycin; Phencyclidine; Piperazines; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes; Tritium | 1992 |
Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Animals; Cerebral Ventricles; Electric Stimulation; Evoked Potentials; Hippocampus; Injections, Intraventricular; Male; Piperidines; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Time Factors | 1992 |
Effects of ifenprodil on the N-methyl-D-aspartate receptor ionophore complex in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1992 |
A pilot study of N-methyl-D-aspartate (NMDA) antagonist in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Drug Therapy, Combination; Humans; Levodopa; Neurologic Examination; Parkinson Disease; Pilot Projects; Piperidines; Receptors, N-Methyl-D-Aspartate | 1992 |
Polyamine-sensitive binding of [125I]ifenprodil in washed, frozen-thawed synaptic membranes: evidence for high affinity binding requiring an open NMDA channel.
Topics: Animals; In Vitro Techniques; Kinetics; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Effects of N-methyl-D-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice.
Topics: Animals; Binding Sites; Carbon Monoxide Poisoning; Dizocilpine Maleate; Glycine; Hippocampus; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1992 |
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nimodipine; Piperidines; Postural Balance; Pyrimidines; Receptors, Opioid; Receptors, sigma; Seizures | 1991 |
Polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of cyclic GMP in the cerebellum.
Topics: Animals; Biogenic Polyamines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Injections, Intraventricular; Male; Methamphetamine; Mice; Neural Pathways; Ornithine; Pentylenetetrazole; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diazepam; Dizocilpine Maleate; Glutamate Decarboxylase; Haloperidol; Ibotenic Acid; Injections; Male; Nerve Degeneration; Pipecolic Acids; Piperazines; Piperidines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.
Topics: Adrenergic alpha-Antagonists; Animals; Molecular Structure; N-Methylaspartate; Piperidines; Rats; Receptors, Adrenergic, alpha; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 1991 |
Polyamine and ifenprodil interactions with the NMDA receptor's glycine site.
Topics: Animals; Binding Sites; Drug Interactions; Glutamates; Glutamic Acid; Glycine; Male; Piperidines; Polyamines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Statistics as Topic | 1991 |
Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Ibotenic Acid; Ion Channels; N-Methylaspartate; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1991 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
[3H]MK-801 binding to N-methyl-D-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine.
Topics: Animals; Binding Sites; Brain; Chromatography, Gel; Desipramine; Dizocilpine Maleate; Glycine; Ligands; Male; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Solubility; Tritium | 1991 |
[125I]Ifenprodil: a convenient radioligand for binding and autoradiographic studies of the polyamine-sensitive site of the NMDA receptor.
Topics: Animals; Autoradiography; Biogenic Polyamines; Calcium; Cerebral Cortex; Iodine Radioisotopes; Isotope Labeling; Magnesium; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Zinc | 1991 |
Pharmacological characterisation and autoradiographic distribution of polyamine-sensitive [3H]ifenprodil binding sites in the rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Kinetics; Male; Organ Specificity; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Inhibition of rat brain monoamine oxidase activity by cerebral anti-ischemic agent, ifenprodil.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Lung; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Animals; Chick Embryo; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperidines; Quinoxalines; Retina | 1990 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Ifenprodil and SL 82.0715 potently inhibit binding of [3H](+)-3-PPP to sigma binding sites in rat brain.
Topics: Animals; Binding, Competitive; Brain; Dopamine Agents; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Tritium | 1990 |
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dogs; Female; Flunarizine; Heart Rate; Male; Piperidines; Pressoreceptors; Reflex; Vagotomy; Vagus Nerve; Vasodilator Agents | 1990 |
Ifenprodil potently interacts with [3H](+)-3-PPP-labeled sigma binding sites in guinea pig brain membranes.
Topics: Animals; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Piperidines; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Inhibition of climbing and mossy fiber, and basket and stellate cell inputs to mouse cerebellar Purkinje cells by novel anti-ischemic agents, ifenprodil and BMY-14802.
Topics: Analysis of Variance; Animals; Cyclic GMP; Harmaline; Male; Methamphetamine; Mice; Mice, Inbred Strains; Neurons; Pentylenetetrazole; Piperazines; Piperidines; Purkinje Cells; Pyrimidines; Radioimmunoassay; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex.
Topics: Animals; Aspartic Acid; Biogenic Polyamines; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Comparative neuroprotective effects of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus.
Topics: Animals; Cell Survival; Flunarizine; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Pentobarbital; Piperidines; Vinca Alkaloids | 1990 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Glutamates; Male; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1989 |
Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Glycine; Injections; Male; Mice; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Time Factors | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
[Pharmacological study of TJ-8007 (tsumura-zokumeito) (II): Protective effect of TJ-8007 against cerebral ischemia].
Topics: Animals; Brain Ischemia; Carotid Artery, Internal; Dogs; Drugs, Chinese Herbal; Female; Gerbillinae; Male; Mice; Piperidines; Regional Blood Flow; Vasodilator Agents; Vertebral Artery | 1989 |
Effects of ifenprodil tartrate on calcium flux in arteries and brain synaptosomes.
Topics: Animals; Aorta, Thoracic; Arteries; Brain Chemistry; Calcium; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Piperidines; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Pharmacological actions of ifenprodil in the rat isolated anococcygeus muscle.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium Chloride; Carbachol; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperidines; Potassium Chloride; Rats; Vasodilator Agents | 1985 |
The mode of action of ifenprodil tartrate in isolated canine cerebral and femoral arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Cerebral Arteries; Dinoprost; Dogs; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oxygen; Piperidines; Potassium; Prostaglandins F | 1987 |
Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Chlordiazepoxide; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Drug Interactions; Generalization, Stimulus; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Effect of cilostazol on experimental cerebral infarction in rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Azoles; Brain; Cerebral Infarction; Cilostazol; Injections, Intravenous; Piperidines; Rabbits; Tetrazoles; Vasodilator Agents | 1986 |
[A quantitative measurement of the cerebral infarct focus induced by arachidonate infusion and the relationship between measured values and stroke signs].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain; Cerebral Infarction; Cerebrovascular Disorders; Drug Evaluation; gamma-Aminobutyric Acid; Male; Pantothenic Acid; Piperidines; Rats; Rats, Inbred Strains | 1988 |
A possible mechanism on the potentiating vascular effect of coadministration of ifenprodil tartrate and calcium hopantenate: a study in the internal carotid artery.
Topics: Animals; Blood Flow Velocity; Calcium; Carotid Artery, Internal; Cerebrovascular Disorders; Dogs; Drug Synergism; Drug Therapy, Combination; gamma-Aminobutyric Acid; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Pantothenic Acid; Piperidines; Rats; Rats, Inbred Strains; Vascular Resistance | 1988 |
A possible mechanism on the potentiated vascular effect of coadministration of ifenprodil tartrate and calcium hopantenate: a study in the basilar and vertebral arteries.
Topics: Animals; Basilar Artery; Blood Flow Velocity; Calcium; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Female; gamma-Aminobutyric Acid; Male; Pantothenic Acid; Piperidines; Rats; Vertebral Artery | 1988 |
[The mode for the manifestation of the inhibitory effects of ifenprodil tartrate on platelet aggregation in vivo and ex vivo].
Topics: Administration, Oral; Animals; Blood Platelets; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Piperidines; Platelet Aggregation Inhibitors; Vasodilator Agents | 1988 |
Effects of ifenprodil tartrate on vertebral, basilar and internal carotid arteries.
Topics: Animals; Basilar Artery; Carotid Arteries; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth, Vascular; Piperidines; Rats; Rats, Inbred Strains; Regional Blood Flow; Time Factors; Vasodilator Agents; Vertebral Artery | 1988 |
[Effects of ifenprodil tartrate on erythrocyte deformability and cerebral blood flow].
Topics: Adenine Nucleotides; Animals; Cerebrovascular Circulation; Erythrocyte Deformability; Erythrocytes; Fibrinogen; Hematocrit; In Vitro Techniques; Male; Piperidines; Rats; Rats, Inbred Strains; Regional Blood Flow | 1987 |
[Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage].
Topics: Animals; Brain Damage, Chronic; Coma; Drugs, Chinese Herbal; Hypoxia, Brain; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Papaverine; Phenytoin; Piperidines; Plant Extracts; Potassium Cyanide; Rats; Rats, Inbred Strains | 1987 |
Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction.
Topics: Animals; Dogs; Glucuronates; In Vitro Techniques; Male; Piperidines; Platelet Aggregation; Rabbits; Vasoconstriction; Vasodilator Agents | 1987 |
[Action of ifenprodil tartrate in obliterative arteriopathies of the lower limbs. Combined studies using proximal blood flow and distal transcutaneous oxygen pressure].
Topics: Adult; Aged; Arterial Occlusive Diseases; Blood Gas Monitoring, Transcutaneous; Female; Humans; Leg; Male; Microcirculation; Middle Aged; Piperidines; Regional Blood Flow; Vasodilator Agents | 1986 |
[Inhibitory mechanism of ifenprodil tartrate on rabbit platelet aggregation].
Topics: Animals; Aorta; Blood Platelets; Depression, Chemical; Drug Synergism; Epoprostenol; In Vitro Techniques; Male; Piperidines; Platelet Aggregation; Rabbits; Serotonin | 1985 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Diseases; Constriction, Pathologic; gamma-Aminobutyric Acid; Gerbillinae; Male; Pantothenic Acid; Piperidines | 1985 |
[Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect].
Topics: Animals; Atmospheric Pressure; Coma; Dihydroergotoxine; Drug Therapy, Combination; gamma-Aminobutyric Acid; Hypoxia, Brain; Mice; Morpholines; Pantothenic Acid; Physostigmine; Piperidines; Potassium Cyanide | 1985 |
[Effects of ifenprodil on lateral vestibular nucleus neurons in the cat (author's transl)].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Female; Male; Neurons; Piperidines; Vestibular Nuclei | 1981 |
[Role of gamma cineangiography in the evaluation of chronic cerebral arteriopathies].
Topics: Adult; Aged; Cerebral Arterial Diseases; Chronic Disease; Female; Gamma Rays; Humans; Male; Middle Aged; Piperidines; Radionuclide Imaging; Technetium; Vasodilator Agents | 1983 |
[Studies on isolated rat hepatocytes (6)].
Topics: Actihaemyl; Animals; Anti-Inflammatory Agents; Cefoperazone; Cell Survival; Cells, Cultured; Glutathione; Ketoprofen; Liver; Oxygen Consumption; Pipemidic Acid; Piperidines; Piroxicam; Pyridazines; Rats; Rats, Inbred Strains; Rifampin; Thiazines | 1984 |
[The effect of vinpocetine on brain glucose uptake in mice].
Topics: Administration, Oral; Animals; Brain; Glucose; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Piperidines; Vasodilator Agents; Vinca Alkaloids | 1982 |
Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels.
Topics: Acetylcholine; Animals; Cats; Cerebral Arteries; Cerebrovascular Disorders; Female; Humans; Male; Norepinephrine; Papaverine; Phentolamine; Pia Mater; Piperidines; Potassium; Serotonin; Vasodilator Agents; Vincamine; Xanthines | 1981 |
Stimulation of guinea pig brain mitochondrial respiration by ifenprodil.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane; Dinitrophenols; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Mitochondria; Oxygen Consumption; Phosphates; Piperidines; Potassium; Sodium; Succinate Dehydrogenase; Succinates; Time Factors | 1980 |
Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells.
Topics: Animals; Binding Sites; Cell Line; Glutamic Acid; Glycine; Humans; Mice; Piperidines; Rabbits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 1995 |
Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?
Topics: Animals; Biguanides; Dizocilpine Maleate; Histamine Release; In Vitro Techniques; Kinetics; Mast Cells; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Ifenprodil inhibition of the 5-hydroxytryptamine3 receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Kainic Acid; Patch-Clamp Techniques; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Time Factors; Vasodilator Agents | 1995 |
Blockade by polyamine NMDA antagonists related to ifenprodil of NMDA-induced synthesis of cyclic GMP, increases in calcium and cytotoxicity in cultured neurones.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; N-Methylaspartate; Neurons; Piperidines; Propanolamines; Receptors, N-Methyl-D-Aspartate | 1995 |
Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Ethanol; Humans; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1995 |
In vivo labeling of sigma receptors in mouse brain with [3H]4-phenyl-1-(4-phenylbutyl)piperidine.
Topics: Animals; Binding, Competitive; Brain Chemistry; Haloperidol; Injections, Intravenous; Ligands; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Topics: Animals; Cell Death; Cells, Cultured; Genes, fos; Hippocampus; Male; Mice; N-Methylaspartate; Nerve Degeneration; Piperidines; Rats; Structure-Activity Relationship | 1995 |
Polyamines and NMDA receptors modulate pericapillary astrocyte swelling following cerebral cryo-injury in the rat.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain; Brain Injuries; Capillaries; Cold Temperature; Dizocilpine Maleate; Eflornithine; Ornithine Decarboxylase; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Statistics as Topic | 1995 |
AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Gerbillinae; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kinetics; Male; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
The mechanism of the neurotoxic effects of spermidine.
Topics: Animals; Cerebral Ventricles; Dizocilpine Maleate; Guanidines; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; Neurotoxins; Oxidoreductases Acting on CH-NH Group Donors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate; Spermidine; Stereotyped Behavior | 1994 |
Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells.
Topics: Animals; Animals, Newborn; Base Sequence; Blotting, Southern; Cerebellum; DNA; Electrophysiology; Glutamate Decarboxylase; In Vitro Techniques; Molecular Sequence Data; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1994 |
Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit.
Topics: Animals; Glutamic Acid; Glycine; Histamine; Oocytes; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus laevis | 1995 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors.
Topics: Animals; Binding, Competitive; Drug Interactions; In Vitro Techniques; Kinetics; Ligands; Male; Pentazocine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism | 1995 |
Subtypes of NMDA receptor in neurones cultured from rat brain.
Topics: Animals; Brain; Brain Chemistry; Cells, Cultured; Glycine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Dizocilpine Maleate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1995 |
Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Excitatory Amino Acids; Fluorescent Dyes; Hippocampus; Mice; Patch-Clamp Techniques; Piperidines; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Heterocyclic amino alcohols related to ifenprodil as sigma receptor ligands: binding and conformational analyses.
Topics: Adrenergic alpha-Antagonists; Amino Alcohols; Animals; Binding, Competitive; Cerebral Cortex; Crystallization; Dopamine Agonists; Heterocyclic Compounds; In Vitro Techniques; Ligands; Models, Molecular; Molecular Conformation; Piperidines; Propanolamines; Rats; Receptors, Adrenergic, alpha-1; Receptors, sigma | 1994 |
The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Drug Synergism; Electroshock; Male; Memory; Mice; Movement; Piperidines; Procyclidine; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A.
Topics: Animals; Brain; Cell Survival; Dizocilpine Maleate; Electrophysiology; Membranes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Transfection | 1995 |
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Electrophysiology; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1993 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Further characterization of [3H]ifenprodil binding in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Rats; Rats, Inbred F344; Receptors, sigma | 1994 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
[3H]dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-methyl-D-aspartate receptors.
Topics: Animals; Biguanides; Binding Sites; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Male; Piperidines; Polyamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 1994 |
Autoradiographic distribution and characteristics of high- and low-affinity polyamine-sensitive [3H]ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Calmodulin; Hippocampus; Imidazoles; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sepharose; Spermidine; Spermine; Sulfonamides; Tissue Distribution; Trifluoperazine; Tritium | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: comparison with CPPene.
Topics: Acoustic Stimulation; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Dextromethorphan; Dizocilpine Maleate; Epilepsy; Injections, Intraperitoneal; Ketamine; Male; Movement; Phencyclidine; Piperazines; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
N-methyl-D-aspartate (NMDA) antagonists in Parkinson's disease.
Topics: Adrenergic alpha-Antagonists; Humans; Parkinson Disease; Piperidines; Receptors, N-Methyl-D-Aspartate | 1993 |
Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytosol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1993 |
Influence of ifenprodil on the ACTH-induced behavioral syndrome in rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Piperidines; Rats; Rats, Wistar | 1994 |
Differential profiles of binding of a radiolabeled agonist and antagonist at a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1994 |
Further characterization of [3H]ifenprodil binding to sigma receptors in rat brain.
Topics: Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism | 1993 |
Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Cells, Cultured; Cerebral Cortex; Cloning, Molecular; Dizocilpine Maleate; Female; Gene Expression; Neurons; Oocytes; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection; Xenopus laevis | 1993 |
Spermine promotes the survival of primary cultured brain neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Hippocampus; Neurons; Piperidines; Putrescine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1993 |
125I-ifenprodil: synthesis and characterization of binding to a polyamine-sensitive site in cerebral cortical membranes.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1993 |
Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ibogaine; Male; Mice; Piperidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism.
Topics: Animals; Brain; Brain Ischemia; Hippocampus; Male; Monoamine Oxidase Inhibitors; Piperidines; Rats; Rats, Wistar | 1995 |
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Genetic Variation; Humans; Kidney; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine; Transfection | 1996 |
Pharmacological and immunological characterization of N-methyl-D-aspartate receptors in human NT2-N neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immunoblotting; Kynurenic Acid; Neurons; Piperidines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex.
Topics: Animals; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Histamine Release; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneum; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Thalamus | 1996 |
An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.
Topics: Amino Acid Sequence; Animals; Female; Hydrogen-Ion Concentration; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship; Xenopus | 1996 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotective Agents; Piperazines; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tremor | 1996 |
Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-methyl-d-aspartate receptors.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1996 |
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus | 1996 |
Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
Topics: Animals; Base Sequence; Cloning, Molecular; Molecular Sequence Data; Oocytes; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Xenopus laevis | 1996 |
NMDA receptor antagonists block development of tolerance to m-CPP-induced increases in ACTH concentrations in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dimethyl Sulfoxide; Dizocilpine Maleate; Drug Tolerance; Kynurenic Acid; Male; Phencyclidine; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine, in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Calcium; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Naloxone; Pain Threshold; Piperidines; Receptors, N-Methyl-D-Aspartate | 1996 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
Time-dependent changes in NMDA receptor expression in neurones cultured from rat brain.
Topics: Animals; Brain; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.
Topics: Animals; Body Temperature; Brain Ischemia; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds.
Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dantrolene; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin | 1996 |
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Hearing Tests; Kanamycin; Male; N-Methylaspartate; Neomycin; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Interactions between ethanol and agents that act on the NMDA-type glutamate receptor.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Brain; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Humans; Ion Channels; Motivation; Piperidines; Receptors, N-Methyl-D-Aspartate; Taurine | 1996 |
Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil.
Topics: Age Factors; Animals; Dendrites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kinetics; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses | 1996 |
Interactions between ifenprodil and dizocilpine on mouse behaviour in models of anxiety and working memory.
Topics: Animals; Anxiety; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mice, Inbred Strains; Piperidines | 1996 |
Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors.
Topics: Animals; Base Sequence; Binding Sites; DNA Primers; Enzyme Inhibitors; Ergosterol; Guinea Pigs; Haloperidol; Kinetics; Ligands; Mutation; Piperidines; Receptors, sigma; Saccharomyces cerevisiae; Steroid Isomerases; Trifluperidol | 1996 |
A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Models, Biological; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Cats; Cerebral Infarction; Excitatory Amino Acid Antagonists; Female; Male; Piperidines; Regional Blood Flow; Vasodilator Agents | 1997 |
Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Female; Haloperidol; Illicit Drugs; Kinetics; Oocytes; Phencyclidine; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Trifluperidol; Xenopus | 1997 |
Protective effect of ifenprodil against glucose deprivation-induced damage in cultured rat hippocampal neurons.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Culture Media; Drug Antagonism; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; L-Lactate Dehydrogenase; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure.
Topics: Animals; Animals, Newborn; Calcium; Cells, Cultured; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fura-2; Glycine; Image Processing, Computer-Assisted; Kinetics; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Presynaptic control of subunit composition of NMDA receptors mediating synaptic plasticity.
Topics: Animals; Bicuculline; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Macromolecular Substances; Magnesium; N-Methylaspartate; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Presynaptic Terminals; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Kynurenic Acid; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1997 |
Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes.
Topics: Animals; Excitatory Amino Acid Antagonists; Haloperidol; Hydrogen-Ion Concentration; Neuroprotective Agents; Nylidrin; Oocytes; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1997 |
High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Clomiphene; Estrogen Antagonists; Excitatory Amino Acid Antagonists; Fertility Agents, Female; Fungicides, Industrial; Guinea Pigs; Hypolipidemic Agents; Isoquinolines; Isotope Labeling; Microsomes; Microsomes, Liver; Morpholines; Pentazocine; Piperidines; Receptors, sigma; Saccharomyces cerevisiae; Stereoisomerism; Steroid Isomerases; Tamoxifen; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol; Verapamil | 1997 |
Chronic corticosterone treatment induces parallel changes in N-methyl-D-aspartate receptor subunit messenger RNA levels and antagonist binding sites in the hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Binding, Competitive; Cell Membrane; Corticosterone; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucocorticoids; Hippocampus; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Testosterone | 1997 |
N-methyl-D-aspartate receptor-mediated events contribute to neurovascular breakdown during experimental allergic encephalomyelitis.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Cerebellum; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Male; Piperidines; Putrescine; Rats; Rats, Inbred Lew; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 1997 |
The influence of nicardipine and ifenprodil on the brain free arachidonic acid level and behavior in hypoxia-exposed rats.
Topics: Animals; Arachidonic Acid; Brain; Female; Hypoxia; Learning; Nicardipine; Piperidines; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Female; Ligands; Neuroprotective Agents; Oocytes; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Xenopus | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Retinal activity regulates developmental switches in functional properties and ifenprodil sensitivity of NMDA receptors in the lateral geniculate nucleus.
Topics: Action Potentials; Aging; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Ferrets; Geniculate Bodies; In Vitro Techniques; Kinetics; Patch-Clamp Techniques; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Tetrodotoxin; Thalamus | 1997 |
Ifenprodil attenuates the loss of parietal cortical parvalbumin immunoreactivity after focal cerebral ischemia in the mouse.
Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Excitatory Amino Acid Antagonists; Immunohistochemistry; Interneurons; Ischemic Attack, Transient; Male; Mice; Parietal Lobe; Parvalbumins; Piperidines | 1997 |
Ethanol specifically inhibits NMDA receptors with affinity for ifenprodil in the low micromolar range in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Piperidines; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells.
Topics: Animals; Calcium; Cell Line; Drug Combinations; Electric Conductivity; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Intracellular Membranes; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1997 |
Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Body Water; Brain; Brain Edema; Cerebral Infarction; Coloring Agents; Evans Blue; Excitatory Amino Acid Antagonists; Hemoglobins; Infusions, Intravenous; Ischemic Attack, Transient; Male; Neuroprotective Agents; Oxygen; Piperidines; Rats; Rats, Inbred SHR; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Sodium Chloride; Temporal Muscle; Vasodilator Agents | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
Topics: Animals; Calcium Channels; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Phenols; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1997 |
[Ototoxicity of aminoglycoside antibiotics: an alternative in sight?].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Dizocilpine Maleate; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss, Sensorineural; Humans; Neuroprotective Agents; Piperidines; Risk Factors | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Age-related decrease in the antiseizure effect of ifenprodil against pentylenetetrazole in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Reaction Time | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist.
Topics: Animals; Benzamides; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kinetics; Piperidines; Protein Binding; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1998 |
Regulation of kinetic and pharmacological properties of synaptic NMDA receptors depends on presynaptic exocytosis in rat hippocampal neurones.
Topics: Animals; Coculture Techniques; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exocytosis; Hippocampus; Kinetics; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Synaptic Membranes; Tetanus Toxin | 1998 |
Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade.
Topics: Amyloid beta-Peptides; Animals; Cerebral Cortex; Cholinesterases; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Space; Histocytochemistry; Male; NADPH Dehydrogenase; Nitric Oxide Synthase; Parasympathectomy; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1998 |
Inhibition of ornithine decarboxylase by ifenprodil.
Topics: Biogenic Polyamines; Eflornithine; Enzyme Inhibitors; Escherichia coli; Excitatory Amino Acid Antagonists; Ornithine Decarboxylase Inhibitors; Piperidines; Putrescine; Receptors, N-Methyl-D-Aspartate | 1998 |
Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus.
Topics: Animals; Binding Sites; Dynorphins; Electric Conductivity; Electric Stimulation; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; Male; Naloxone; Narcotic Antagonists; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate | 1998 |
Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions.
Topics: Amino Acid Sequence; Binding, Competitive; Chimera; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Mutagenesis, Site-Directed; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine | 1998 |
NMDA receptor antagonists potently suppress the spontaneous withdrawal signs induced by discontinuation of long-term diazepam treatment in Fischer 344 rats.
Topics: Administration, Oral; Animals; Anorexia; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Dizocilpine Maleate; Eating; Emotions; Excitatory Amino Acid Antagonists; Male; Motor Activity; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Time Factors; Weight Loss | 1998 |
Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Edema; Brain Injuries; Cardiovascular Physiological Phenomena; Cognition; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Protective effect of GV150526A on the glutamate-induced changes in basal and electrically-stimulated cytosolic Ca++ in primary cultured cerebral cortical cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Indoles; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons.
Topics: Allosteric Site; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Ion Channel Gating; Kidney; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1998 |
Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Bacterial Agents; Carbohydrate Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kanamycin; Male; Molecular Sequence Data; Neomycin; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
[Exploration of the deep dorsal vein of the penis using pulsed Doppler ultrasonography. Preliminary study].
Topics: Adult; Aged; Alprostadil; Erectile Dysfunction; Humans; Male; Middle Aged; Penis; Piperidines; Ultrasonography, Doppler, Pulsed; Vasodilator Agents; Veins | 1998 |
Effects of NMDA receptor antagonists on D1 dopamine receptor-mediated changes in striatal immediate early gene expression: evidence for involvement of pharmacologically distinct NMDA receptors?
Topics: Animals; Corpus Striatum; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Male; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1998 |
An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.
Topics: Animals; Arginine; CHO Cells; Cricetinae; Dizocilpine Maleate; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Iodine Radioisotopes; Piperidines; Point Mutation; Receptors, N-Methyl-D-Aspartate | 1998 |
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.
Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
Pharmacological analysis of sterol delta8-delta7 isomerase proteins with [3H]ifenprodil.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Carrier Proteins; Dopamine Antagonists; Estrogen Antagonists; Excitatory Amino Acid Antagonists; Guinea Pigs; Haloperidol; Isoenzymes; Kinetics; Mice; Microsomes; Microsomes, Liver; Piperidines; Saccharomyces cerevisiae; Steroid Isomerases; Tamoxifen; Tritium | 1998 |
Inhibition of 5-HT3 receptor cation channels by ifenprodil in excised patches of N1E-115 cells.
Topics: Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Electrophysiology; Free Radical Scavengers; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Sodium Channels; Tumor Cells, Cultured | 1998 |
Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons.
Topics: Animals; Calcium Channels; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-6; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1998 |
Differential effects of N-methyl-D-aspartate receptor blockade on eticlopride-induced immediate early gene expression in the medial and lateral striatum.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Gene Expression; Genes, Immediate-Early; Male; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Salicylamides | 1998 |
Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memory, Short-Term; Motor Activity; Piperazines; Piperidines; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1998 |
Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Asparagine; Carrier Proteins; Cell Membrane; Glutamic Acid; Histidine; Humans; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Peptide Fragments; Piperidines; Saccharomyces cerevisiae; Steroid Isomerases; Threonine; Tryptophan | 1999 |
Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat.
Topics: Animals; Antiparkinson Agents; Binding, Competitive; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine | 1999 |
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1999 |
Effects of c-Src tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells.
Topics: Animals; Blotting, Western; Cell Line; Central Nervous System Depressants; CSK Tyrosine-Protein Kinase; Ethanol; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique, Direct; Humans; Microscopy, Video; Mutagenesis, Site-Directed; Piperidines; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; src-Family Kinases; Transfection | 1999 |
Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating: immunochemical/behavioral evidence.
Topics: Animals; Behavior, Animal; Blotting, Western; Excitatory Amino Acid Antagonists; Feeding Behavior; Food Deprivation; Hypothalamic Area, Lateral; Immunohistochemistry; Isomerism; Kainic Acid; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition.
Topics: Animals; Excitatory Amino Acid Antagonists; Female; Hydrogen-Ion Concentration; Neuroprotective Agents; Oocytes; Piperidines; Protons; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus laevis | 1998 |
Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation.
Topics: Animals; Biological Transport; Blotting, Western; Carrier Proteins; Cerebral Cortex; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Chloride Symporters; Staining and Labeling | 1999 |
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Animals, Suckling; Bicuculline; Cycloheximide; Darkness; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Light; Male; Models, Neurological; Nerve Tissue Proteins; Neuronal Plasticity; Optic Nerve; Photic Stimulation; Piperidines; Protein Synthesis Inhibitors; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sensory Deprivation; Synapses; Vision, Ocular; Visual Cortex; Zinc | 1999 |
Ethanol sensitivity of NMDA receptor function in developing cerebellar granule neurons.
Topics: Animals; Blotting, Western; Calcium; Cell Culture Techniques; Central Nervous System Depressants; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Nervous System; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1999 |
NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Binding Sites; Cadaver; Excitatory Amino Acid Antagonists; Humans; Isomerism; Piperidines; Receptors, N-Methyl-D-Aspartate; Reference Values; Schizophrenia; Temporal Lobe; Up-Regulation | 1999 |
Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Piperidines; Receptors, N-Methyl-D-Aspartate | 1999 |
The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro.
Topics: Animals; Cell Line; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Humans; Kinetics; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1999 |
Developmental regulation of NMDA receptor 2B subunit mRNA and ifenprodil binding in the zebra finch anterior forebrain.
Topics: Animals; Critical Period, Psychological; Excitatory Amino Acid Antagonists; In Situ Hybridization; Male; Molecular Sequence Data; Piperidines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Songbirds; Vocalization, Animal | 1999 |
Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells.
Topics: Animals; Animals, Newborn; Cell Line; Cells, Cultured; Cerebellum; Drug Synergism; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1999 |
Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Brain; Cell Membrane; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Male; Neurons; Organ Specificity; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium; Zinc | 1999 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain Measurement; Phenols; Piperidines; Pyrrolidinones; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Triazines | 1999 |
A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Carrier Proteins; Excitatory Amino Acid Antagonists; Exons; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Piperidines; Protein Conformation; Protons; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA Splicing; Sequence Homology, Amino Acid; Spermine; Xenopus laevis | 1999 |
Ifenprodil and arcaine alter amygdala-kindling development.
Topics: Amygdala; Animals; Anticonvulsants; Biguanides; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intraventricular; Kindling, Neurologic; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Pharmacological characterization of [3H]-Ifenprodil binding to polyamine binding sites on rabbit and rat retinal homogenates: role in neuroprotection?
Topics: Animals; Binding, Competitive; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Piperidines; Polyamines; Rabbits; Rats; Retina; Tritium | 1999 |
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection?
Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina | 1999 |
Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Male; Mice; Piperidines; Prazosin; Seizures; Sleep; Substance Withdrawal Syndrome | 1999 |
Effects of ifenprodil and baclofen on exercise-induced increase of myocardial oxygen demand in normotensive rats.
Topics: Animals; Baclofen; Baroreflex; Blood Pressure; Excitatory Amino Acid Antagonists; Exercise Test; GABA Agonists; Male; Myocardium; Oxygen Consumption; Physical Exertion; Piperidines; Rats; Rats, Inbred WKY; Receptors, Glutamate; Synapses | 1999 |
Pharmacological differences and similarities between the native mouse 5-HT3 receptor in N1E-115 cells and a cloned short splice variant of the mouse 5-HT3 receptor expressed in HEK 293 cells.
Topics: Alternative Splicing; Animals; Binding, Competitive; Carbon Radioisotopes; Cell Line; Cloning, Molecular; DNA, Complementary; Dose-Response Relationship, Drug; Gene Expression; Genetic Variation; Guanidine; Humans; Hybrid Cells; Imidazoles; Indoles; Isoindoles; Membranes; Mice; Piperidines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Sequence Analysis, DNA; Serotonin; Serotonin Agents; Substance P; Transfection; Tritium; Tumor Cells, Cultured | 1999 |
Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells.
Topics: Animals; Animals, Newborn; Gene Expression Regulation, Developmental; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Protein Structure, Quaternary; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus | 2000 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Humans; In Vitro Techniques; Patch-Clamp Techniques; Piperidines; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Excitatory Amino Acid Antagonists; Hexachlorophene; Male; Motor Activity; Motor Skills Disorders; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2000 |
Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord.
Topics: Animals; Electric Conductivity; Excitatory Postsynaptic Potentials; In Vitro Techniques; Ion Channels; Magnesium; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Substantia Gelatinosa | 2000 |
Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses.
Topics: Animals; Cell Polarity; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Phenols; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses | 2000 |
Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Ethylenediamines; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2000 |
Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency.
Topics: Animals; Antibodies; Brain Diseases, Metabolic, Inborn; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Glutarates; Glutaryl-CoA Dehydrogenase; Neurons; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperidines; Rats | 2000 |
[3H]ifenprodil binding to NMDA receptors in porcine hippocampal brain membranes.
Topics: Animals; Azides; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanidines; Hippocampus; In Vitro Techniques; Kinetics; Membranes; Piperidines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Subcellular Fractions; Swine | 2000 |
Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements.
Topics: Animals; Benzimidazoles; Electrophysiology; Excitatory Amino Acid Antagonists; Hydantoins; Hydrogen Bonding; Male; Neuroprotective Agents; Oocytes; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sympatholytics; Xenopus | 2000 |
Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones.
Topics: Animals; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Ion Channels; Neocortex; Neurons; Patch-Clamp Techniques; Picrotoxin; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synapses | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Electrophysiological analysis of NMDA receptor subunit changes in the aging mouse cortex.
Topics: Aging; Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Electric Conductivity; Excitatory Amino Acid Antagonists; Female; Frontal Lobe; Injections; Magnesium; Mathematics; Mice; Mice, Inbred C57BL; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Xenopus laevis | 2000 |
Effect of ifenprodil on aqueous humor dynamics and optic nerve head circulation in rabbits.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Blood Circulation; Blood Pressure; Blood-Aqueous Barrier; Capillary Permeability; Fluorophotometry; Optic Disk; Piperidines; Rabbits; Sclera; Uvea; Vasodilator Agents | 2000 |
Effects of N-methyl-D-aspartate receptor subunit antagonists on regulation of susceptibility to audiogenic seizures in rats.
Topics: Animals; Dextromethorphan; Disease Susceptibility; Epilepsy, Reflex; Excitatory Amino Acid Antagonists; Female; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2000 |
Methylmalonic acid induces excitotoxic neuronal damage in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Cell Survival; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Methylmalonic Acid; Neurons; Neuroprotective Agents; Neurotoxins; NG-Nitroarginine Methyl Ester; Piperidines | 2000 |
Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence.
Topics: Animals; Ethanol; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Piperidines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 2000 |
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Macaca nemestrina; Neurons; Organ Specificity; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamic Nuclei; Transcription, Genetic; Tritium | 2000 |
Developmental profile of the changing properties of NMDA receptors at cerebellar mossy fiber-granule cell synapses.
Topics: Age Factors; Animals; Cerebellum; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kinetics; Magnesium; Nerve Fibers; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2000 |
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Excitatory Amino Acid Antagonists; Male; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; Dopamine Agents; Excitatory Amino Acid Antagonists; Levodopa; Motor Activity; Parkinson Disease; Parkinson Disease, Secondary; Piperidines | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Effects of conantokins on L-3,4-dihydroxyphenylalanine-induced behavior and immediate early gene expression.
Topics: Animals; Antiparkinson Agents; Conotoxins; DNA-Binding Proteins; Drug Interactions; Early Growth Response Protein 1; Excitatory Amino Acid Antagonists; Gene Expression; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Levodopa; Male; Mollusk Venoms; Peptides; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Transcription Factors | 2000 |
Altered receptor subunit expression in rat neocortical malformations.
Topics: Animals; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Freezing; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, GABA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Zolpidem | 2000 |
Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Antagonists; Guanosine Triphosphate; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2000 |
Characterisation of N-methyl-D-aspartate receptor-specific [(3)H]Ifenprodil binding to recombinant human NR1a/NR2B receptors compared with native receptors in rodent brain membranes.
Topics: Allosteric Site; Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cell Line; Cell Membrane; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Male; Mice; Piperidines; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2000 |
Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents.
Topics: Action Potentials; Calcineurin; Calcineurin Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Developmental; In Vitro Techniques; Ion Transport; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses; Tacrolimus | 2000 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits.
Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Excitatory Amino Acid Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Membranes; Oocytes; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Trifluoperazine; Xenopus; Zinc | 2001 |
Protective effects of ifenprodil against glutamate-induced neurotoxicity in cultured retinal neurons.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine | 2000 |
Effect of ifenprodil on ocular tissue circulation in rabbits.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Choroid; Intraocular Pressure; Iris; Laser-Doppler Flowmetry; Ophthalmic Solutions; Optic Disk; Piperidines; Rabbits; Vasodilator Agents | 2000 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex.
Topics: Animals; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kinetics; Male; N-Methylaspartate; Perfusion; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2001 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Topics: Animals; Brain; Cell Line; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Humans; Kinetics; Mice; Mutation; Phenols; Piperidines; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine | 2001 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation, Developmental; Humans; Indoles; Kainic Acid; Piperidines; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tritium | 2001 |
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cell Division; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Long-Term Potentiation; Male; Neuronal Plasticity; Neurons; Organ Culture Techniques; Picrotoxin; Piperidines; Rats; Rats, Wistar | 2001 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
Topics: Animals; Dextromethorphan; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Guanidines; Ketamine; Ligands; Male; Phencyclidine; Piperazines; Piperidines; Protein Subunits; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2001 |
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex.
Topics: Animals; Biguanides; Cerebral Cortex; Dizocilpine Maleate; Hydrogen-Ion Concentration; Male; Neuroprotective Agents; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Tritium | 2001 |
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning.
Topics: Acoustic Stimulation; Amygdala; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroshock; Excitatory Amino Acid Antagonists; Fear; Injections, Intraperitoneal; Learning; Male; Memory, Short-Term; Microinjections; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retention, Psychology | 2001 |
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A.
Topics: Allosteric Regulation; Animals; Binding Sites; Cell Line; Edetic Acid; Electric Conductivity; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc | 2001 |
Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor.
Topics: Animals; Dentate Gyrus; Drug Synergism; Ethanol; Excitatory Postsynaptic Potentials; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mutation; Peptide Fragments; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Lead inhibition of NMDA channels in native and recombinant receptors.
Topics: Animals; Cells, Cultured; Cerebellar Cortex; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glycine; Lead; Lead Poisoning, Nervous System; Membrane Potentials; Neurons; Oocytes; Piperidines; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Up-Regulation | 2001 |
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Glycine; Hot Temperature; Piperidines; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Valine | 2001 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Piperidines; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2001 |
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Desipramine; Excitatory Amino Acid Antagonists; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Tetrodotoxin | 2001 |
Distinct NMDA and AMPA receptor-mediated responses in mouse and human Cajal-Retzius cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Mice; Neurons; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition.
Topics: Animals; Brain Mapping; Critical Period, Psychological; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Developmental; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Synapses; Thalamus | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
[A case of eosinophilic pneumonia possibly due to ifenprodil].
Topics: Aged; Female; Humans; Piperidines; Pulmonary Eosinophilia; Vasodilator Agents | 2001 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Nociceptors; Pain; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2002 |
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.
Topics: Brain-Derived Neurotrophic Factor; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Intracellular Membranes; Membrane Potentials; Mitochondria; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Synapses | 2002 |
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem.
Topics: Aging; Animals; Auditory Pathways; Brain Stem; Ethylenediamines; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Developmental; Kinetics; Magnesium; Mice; Piperidines; Protein Subunits; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Zinc | 2002 |
Subtypes of NMDA receptors in new-born rat hippocampal granule cells.
Topics: Animals; Animals, Newborn; Cytoplasmic Granules; Dentate Gyrus; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression.
Topics: Animals; Central Nervous System Depressants; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; Male; Neural Inhibition; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2002 |
NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Conditioning, Psychological; Fear; Kinetics; Long-Term Potentiation; Male; Memory; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Thalamus; Verapamil | 2002 |
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors.
Topics: Animals; Brain; Carbon Radioisotopes; Isotope Labeling; Macaca; Male; Metals; Mice; Piperidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Sensitivity and Specificity; Spermine; Tissue Distribution; Tomography, Emission-Computed; Whole-Body Counting | 2002 |
Effect of multiple ifenprodil or spermidine treatment on social recognition in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Injections, Intraperitoneal; Male; Memory, Short-Term; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Spermidine | 2002 |
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses.
Topics: Animals; Cell Differentiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Fetus; Gene Deletion; Gene Targeting; Glutamic Acid; Mice; Mice, Knockout; Mutation; Neocortex; Neurons; Piperidines; Pregnancy; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tetrodotoxin | 2002 |
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Levodopa; Male; Microinjections; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Piperidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mutagenesis, Site-Directed; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Structure, Tertiary; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Structure-Activity Relationship; Trypsin; Xenopus laevis | 2002 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine | 2002 |
Axonal projection, input and output synapses, and synaptic physiology of Cajal-Retzius cells in the developing rat neocortex.
Topics: Animals; Axons; Dendrites; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Lysine; Neocortex; Nerve Net; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2002 |
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
Topics: Acamprosate; Administration, Oral; Animals; Biguanides; Dose-Response Relationship, Drug; Drug Interactions; Male; Memory, Short-Term; Motor Activity; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sleep; Spermidine; Taurine | 2002 |
Differential regulation of synaptic and extra-synaptic NMDA receptors.
Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Cells, Cultured; Endocytosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; N-Methylaspartate; Phosphoric Monoester Hydrolases; Piperidines; Protein Transport; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2002 |
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Nerve Degeneration; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 2002 |
Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Ion Channel Gating; Isoflurane; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Tachyphylaxis; Time Factors; Transfection | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil.
Topics: Agmatine; Animals; Biguanides; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2002 |
Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus.
Topics: Acamprosate; Animals; Animals, Newborn; Calcium Signaling; Dizocilpine Maleate; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Taurine | 2002 |
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil.
Topics: Aggression; Alcohol-Induced Disorders, Nervous System; Animals; Anxiety; Behavior, Animal; Brain; Drug Resistance; Ethanol; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fear; Female; Genotype; Male; Mice; Mice, Transgenic; Piperidines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing | 2003 |
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Calcium Signaling; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Environmental Exposure; Female; Lead; Lead Poisoning, Nervous System; Male; Neurons; Phosphorylation; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2002 |
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol.
Topics: Anesthetics; Animals; Brain; Brain Chemistry; Cell Line; Central Nervous System Depressants; CHO Cells; Cricetinae; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ion Channel Gating; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pregnanediones; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 2003 |
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum.
Topics: Age Factors; Animals; Animals, Newborn; Corpus Striatum; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Kinetics; Limbic System; Male; Motor Neurons; Neurons, Afferent; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses | 2003 |
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Cells, Cultured; Conserved Sequence; DNA, Complementary; Electric Fish; Electric Organ; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kidney; Molecular Sequence Data; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2003 |
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat.
Topics: Algorithms; Animals; Cell Line; Cerebellum; Disks Large Homolog 4 Protein; DNA; Electrophysiology; Epitopes; Excitatory Amino Acid Antagonists; Green Fluorescent Proteins; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Membrane Potentials; Membrane Proteins; Mutation; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Synapses; Transfection | 2003 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channels; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Guanidines; Membrane Potentials; Mice; Neurons; Nickel; Piperidines; Potassium Channel Blockers; Seizures; Spermine; Spinal Cord; Succinates; Synapses; Tetraethylammonium; Tetrodotoxin; Uremia | 2003 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Colforsin; Culture Techniques; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Immunohistochemistry; Magnesium; Mesencephalon; Neurons; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Phencyclidine; Phenols; Piperidines; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2003 |
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice.
Topics: Animals; Anxiety; Attention; Darkness; Dextromethorphan; Light; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites.
Topics: Animals; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Synapses | 2003 |
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Conotoxins; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Mexiletine; Neurons; Neuroprotective Agents; Piperidines; Pregnancy; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Staurosporine | 2003 |
Polyamines in a genetic animal model of paroxysmal dyskinesia.
Topics: Aging; Animals; Brain; Case-Control Studies; Chorea; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Excitatory Amino Acid Agents; Mutation; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index | 2003 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging.
Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.
Topics: Administration, Oral; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Memory; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Swimming | 2003 |
Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons.
Topics: Amygdala; Animals; Calcium; DNA Probes; Ethanol; Excitatory Amino Acid Antagonists; Glyceraldehyde-3-Phosphate Dehydrogenases; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2003 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response Relationship, Drug; Drug Resistance; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Neurons; Pentylenetetrazole; Piperidines; Putrescine; Seizures | 2003 |
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory.
Topics: Amygdala; Animals; Down-Regulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; In Vitro Techniques; Male; Memory; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 2003 |
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Axons; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Lysine; Membrane Potentials; Microscopy, Confocal; Microscopy, Electron; Nerve Net; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptophysin; Tetrodotoxin; Time Factors | 2003 |
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward.
Topics: Alcohol Drinking; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Receptors, N-Methyl-D-Aspartate; Reward | 2003 |
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[(11)C]one, as a potent NR(1A)/2B subtype selective NMDA PET radiotracer.
Topics: Animals; Brain; Brain Chemistry; Carbon Radioisotopes; Imidazoles; Isotope Labeling; Kinetics; Male; Molecular Structure; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution; Tomography, Emission-Computed | 2003 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil.
Topics: Alternative Splicing; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Female; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 2003 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Re-expression of NR2B-containing NMDA receptors in vitro by suppression of neuronal activity.
Topics: Action Potentials; Animals; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Chick Embryo; Excitatory Amino Acid Antagonists; Membrane Potentials; Neural Inhibition; Neural Pathways; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Synaptic Transmission; Tetrodotoxin | 2004 |
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains.
Topics: Amines; Animals; Binding Sites; Brain; Butylamines; Carbon Radioisotopes; In Vitro Techniques; Injections, Intravenous; Isotope Labeling; Macaca mulatta; Male; Mice; Piperidines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tissue Distribution | 2004 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2004 |
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats.
Topics: Animals; Asphyxia; Brain Edema; Brain Ischemia; Cardiopulmonary Resuscitation; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heart Arrest, Induced; Hemodynamics; Male; Piperidines; Polyamines; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity | 2004 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Motor Activity; Neurons; Neuroprotective Agents; Piperidines; Polyamines; Spermine; Time Factors | 2004 |
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Catalepsy; Cell Count; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Drug Interactions; Ethylenediamines; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Haloperidol; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Piperidines; Prazosin; Prosencephalon; Proto-Oncogene Proteins c-fos; Reaction Time; Receptors, N-Methyl-D-Aspartate; Time Factors | 2004 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2004 |
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Oocytes; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Xenopus | 2004 |
Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex.
Topics: Adrenergic alpha-Antagonists; Animals; Cortical Spreading Depression; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Mice; Piperidines; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2004 |
Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux.
Topics: Aniline Compounds; Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Humans; Kinetics; Mice; Models, Neurological; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors; Transfection; Xanthenes | 2004 |
Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit.
Topics: Animals; Extracellular Fluid; Long-Term Potentiation; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Visual Cortex | 2004 |
NMDA receptor 2B-selective antagonist ifenprodil-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons.
Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Caspases; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 2004 |
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion.
Topics: Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain Injuries; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Male; Occipital Lobe; Organic Chemicals; Parietal Lobe; Piperidines; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Trauma Severity Indices; Wounds, Nonpenetrating | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
NBQX does not affect learning and memory tasks in mice: a comparison with D-CPPene and ifenprodil.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Mice; Neuropsychological Tests; Piperazines; Piperidines; Quinoxalines; Reaction Time | 1992 |
Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Bicuculline; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Immunohistochemistry; Ion Channel Gating; Ion Channels; Membrane Potentials; Microscopy, Confocal; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solvents; Symporters; Time Factors; Toluene | 2005 |
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Ligands; Molecular Sequence Data; Mutation; Piperidines; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus; Zinc | 2005 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation.
Topics: Agmatine; Analysis of Variance; Animals; Behavior, Animal; Biguanides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalins; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Antagonists; Immune Sera; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Nociceptin Receptor; Piperidines; Protein Precursors; Receptors, Opioid; Spinal Cord; Time Factors | 2005 |
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor.
Topics: Alanine; Binding, Competitive; Cell Membrane; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine | 2005 |
The function of the amino terminal domain in NMDA receptor modulation.
Topics: Amino Acid Sequence; Binding Sites; Dimerization; Humans; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Spermine; Zinc | 2005 |
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Calcium; Calcium Channel Blockers; Chelating Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Pregnenolone; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
In vitro characterization of novel NR2B selective NMDA receptor antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Signaling; Carrier Proteins; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kinetics; Membrane Potentials; Mice; Molecular Structure; Nerve Tissue Proteins; Patch-Clamp Techniques; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Methylazoxymethanol Acetate; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Rats | 2005 |
Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Blotting, Western; Conditioning, Psychological; Electroshock; Evoked Potentials; Excitatory Amino Acid Antagonists; Fear; Freezing Reaction, Cataleptic; Immunohistochemistry; Injections, Intraventricular; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphorylation; Piperidines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Reaction Time; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Synaptosomes; Time Factors; Tyrosine | 2005 |
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Glial Cell Line-Derived Neurotrophic Factor; Indoles; Maleimides; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nerve Growth Factors; Piperidines; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2005 |
The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [(3)H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane.
Topics: Animals; Cell Membrane; Dehydroepiandrosterone Sulfate; Frontal Lobe; Kinetics; Piperidines; Pregnanolone; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
Allosteric modulation of 5-HT3 serotonin receptors.
Topics: Adrenergic alpha-Antagonists; Algorithms; Allosteric Regulation; Animals; Binding, Competitive; Cell Line, Tumor; Dose-Response Relationship, Drug; Granisetron; Hybrid Cells; Kinetics; Male; Mice; Models, Biological; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Agents; Tritium; Verapamil | 2005 |
The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia.
Topics: Adolescent; Adult; Child; Child, Preschool; Cortical Synchronization; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Female; Humans; In Vitro Techniques; Infant; Male; Membrane Potentials; Middle Aged; Neocortex; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Reference Values; Single-Blind Method; Statistics, Nonparametric | 2005 |
Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Dendrites; Guanosine Triphosphate; Kinesins; Microtubules; Neurons; Nocodazole; Piperidines; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidinones; Reaction Time; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Central Nervous System Depressants; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Hydrogen-Ion Concentration; Myocardium; Oocytes; Piperidines; Plasmids; Potassium Channels, Inwardly Rectifying; Receptors, G-Protein-Coupled; RNA, Messenger; Xenopus | 2006 |
Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor.
Topics: Amino Acid Sequence; Biochemistry; Circular Dichroism; Histidine; Humans; Inclusion Bodies; Inhibitory Concentration 50; Molecular Sequence Data; Piperidines; Protein Denaturation; Protein Engineering; Protein Folding; Protein Structure, Tertiary; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Solubility | 2005 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Frontal Lobe; Male; Piperidines; Pregnanolone; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2005 |
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity.
Topics: Animals; Animals, Newborn; Behavior, Animal; Drug Administration Schedule; Drug Resistance; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hypnotics and Sedatives; Injections, Subcutaneous; Learning; Neuronal Plasticity; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2005 |
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence.
Topics: Amphetamine-Related Disorders; Animals; Astrocytes; Calcium; Cell Communication; Central Nervous System Stimulants; Coculture Techniques; Conditioning, Operant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Immunohistochemistry; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microscopy, Confocal; Neuroglia; Neurons; Piperidines; Pregnancy; Protein Kinase C; Pyridines; Quinoxalines; Receptors, Glutamate; Synaptic Transmission | 2005 |
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.
Topics: Animals; Animals, Newborn; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cricetinae; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; Mutagenesis; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Synapses; Time Factors; Transfection | 2005 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Piperidines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Staurosporine | 2006 |
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex.
Topics: Analysis of Variance; Animals; Auditory Cortex; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Infusion Pumps, Implantable; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2006 |
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats.
Topics: Animals; Brain; Brain Edema; Down-Regulation; Heart Arrest; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vasodilator Agents | 2005 |
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
Topics: Alzheimer Disease; Animals; Calpain; Caspase Inhibitors; Caspases; Cells, Cultured; CREB-Binding Protein; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; tau Proteins; Transcriptional Activation; Transfection | 2006 |
Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias.
Topics: Allosteric Regulation; Amantadine; Animals; Antipsychotic Agents; Dextrorphan; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Male; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse.
Topics: Age Factors; Animals; Anticonvulsants; Excitatory Postsynaptic Potentials; Female; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sensory Deprivation; Synapses; Ventral Thalamic Nuclei; Vibrissae | 2006 |
The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Brain; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Eating; Excitatory Amino Acid Antagonists; Exploratory Behavior; Food Deprivation; Gene Expression Regulation; Interpersonal Relations; Male; Morphine; Narcotics; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2006 |
NR2B subunit exerts a critical role in postischemic synaptic plasticity.
Topics: Animals; Brain Damage, Chronic; Cerebral Infarction; Cerebrovascular Circulation; Corpus Striatum; Down-Regulation; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Long-Term Potentiation; Male; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2006 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Lidocaine; Magnesium; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 2006 |
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.
Topics: Animals; Chelating Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Organ Culture Techniques; Phenanthrolines; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Zinc | 2006 |
Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine.
Topics: Animals; Male; Mice; Mice, Inbred ICR; Morphine; Nucleus Accumbens; Phosphorylation; Piperidines; Receptors, N-Methyl-D-Aspartate; Reward; src-Family Kinases | 2006 |
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Targeting; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Motor Activity; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Xenopus laevis | 2006 |
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.
Topics: Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anisomycin; Calcium Channel Blockers; Calcium Channels, L-Type; Dentate Gyrus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Emetine; Excitatory Amino Acid Antagonists; Gallopamil; Long-Term Synaptic Depression; Male; Piperidines; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Wakefulness | 2007 |
NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia.
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Evoked Potentials; Neocortex; Patch-Clamp Techniques; Peptide Fragments; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2006 |
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Immunoglobulin G; In Vitro Techniques; Indole Alkaloids; Male; Membrane Potentials; N-Methylaspartate; Neurons; Optic Nerve; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2006 |
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement.
Topics: Amygdala; Animals; Conditioning, Operant; Excitatory Amino Acid Antagonists; Extinction, Psychological; Food Deprivation; Hippocampus; Immunoblotting; Male; Microinjections; Morphine; Morphine Dependence; Narcotics; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Reward; Stress, Psychological; Swimming | 2007 |
Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.
Topics: Amides; Analgesics; Animals; Binding Sites; Chromatography, High Pressure Liquid; Formaldehyde; Indicators and Reagents; Kynurenic Acid; Magnetic Resonance Spectroscopy; Mice; Pain Measurement; Piperidines; Receptors, N-Methyl-D-Aspartate; Spectrophotometry, Infrared; Structure-Activity Relationship | 2007 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Behavior, Animal; Capsaicin; Drug Interactions; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Time Factors; Vibration | 2007 |
Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learning.
Topics: Age Factors; Animals; Behavior, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Finches; In Vitro Techniques; Learning; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Piperidines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Synapses; Vocalization, Animal | 2006 |
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.
Topics: Alcohol Drinking; Animals; Chronic Disease; Disease Models, Animal; Ethanol; Hyperalgesia; Immunoblotting; Immunohistochemistry; Male; Pain Threshold; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2007 |
NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Neuralgia; Patch-Clamp Techniques; Peripheral Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Sensory Thresholds; Synaptic Transmission | 2007 |
Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classical; Drug Administration Routes; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2007 |
Glutamate exocytosis from astrocytes controls synaptic strength.
Topics: Analysis of Variance; Animals; Astrocytes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2007 |
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Behavior, Animal; Dextromethorphan; Ethylenediamines; Immunohistochemistry; Learning Disabilities; Maze Learning; Memory; Nerve Degeneration; Neurotoxicity Syndromes; Piperidines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Phencyclidine; Receptors, sigma; Seizures; Sigma-1 Receptor; Trimethyltin Compounds | 2007 |
Effects of ifenprodil on the discriminative stimulus effects of cocaine in rhesus monkeys.
Topics: Animals; Cocaine; Discrimination, Psychological; Female; Macaca mulatta; Male; Piperidines; Receptors, N-Methyl-D-Aspartate | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Chlorocebus aethiops; COS Cells; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Male; Phenazocine; Phenylephrine; Piperidines; Potassium Channel Blockers; Purkinje Fibers; Rabbits; Receptors, sigma | 2007 |
Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na+ channels in rat sensory neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Ganglia, Spinal; Ion Channel Gating; Ketamine; Lidocaine; Male; Membrane Potentials; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin | 2007 |
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2007 |
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells.
Topics: 2-Amino-5-phosphonovalerate; Cell Adhesion; Cell Line, Tumor; Excitatory Amino Acid Agonists; Glioma; Glutamic Acid; Humans; Hybrid Cells; Neurites; Neuroblastoma; Piperidines; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids | 2007 |
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Critical Period, Psychological; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation; Green Fluorescent Proteins; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2007 |
[Developmental changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors in cultured rat hippocampal neurons].
Topics: Animals; Animals, Newborn; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2007 |
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mice; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2007 |
Improving solubility of NR2B amino-terminal domain of N-methyl-d-aspartate receptor expressed in Escherichia coli.
Topics: Animals; Carrier Proteins; Cloning, Molecular; Escherichia coli; Glutathione Transferase; Maltose-Binding Proteins; Piperidines; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Scattering, Radiation; Solubility; Temperature | 2007 |
Rapid bidirectional switching of synaptic NMDA receptors.
Topics: Aging; Animals; Brain; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Male; Organ Culture Techniques; Piperidines; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2007 |
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding.
Topics: Amino Acid Sequence; Animals; Excitatory Amino Acid Antagonists; Humans; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid | 2007 |
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dentate Gyrus; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Physical Conditioning, Animal; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2007 |
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Death; Chelating Agents; Disease Models, Animal; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Pilocarpine; Piperidines; Receptors, Glutamate; Status Epilepticus; Time Factors | 2007 |
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Coculture Techniques; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Pyridinium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Spinal Cord; Synapses; Synaptic Transmission; Time Factors | 2007 |
NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol.
Topics: Age Factors; Animals; Estradiol; Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Ovariectomy; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma.
Topics: Acoustic Stimulation; Animals; Audiometry; Chronic Disease; Cochlea; Excitatory Amino Acid Antagonists; Hair Cells, Auditory; Hearing; Male; Neuronal Plasticity; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors; Tinnitus; Treatment Outcome | 2007 |
Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS.
Topics: Amygdala; Animals; Central Nervous System; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2008 |
Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system.
Topics: Animals; Circadian Rhythm; Cricetinae; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Motor Activity; Photic Stimulation; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2008 |
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Binding Sites; Brain; Cysteine; Electrophysiology; Membrane Potentials; Models, Chemical; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2008 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Piperidines; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Spermidine; Substance Withdrawal Syndrome | 2008 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Hippocampus; Ion Channels; Male; Piperidines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2008 |
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution.
Topics: Amygdala; Animals; Data Interpretation, Statistical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Male; Neuronal Plasticity; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation.
Topics: Animals; Calcium; Cell Differentiation; Cell Line; Dizocilpine Maleate; Gene Expression Regulation; Growth Cones; Mice; Neurites; Neurotransmitter Agents; Piperidines; Polyamines; Protein Subunits; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2008 |
The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine.
Topics: Animals; Dose-Response Relationship, Drug; Mice; Mutagenesis, Site-Directed; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship | 2008 |
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
Topics: Aging; Animals; Blotting, Western; Electrophysiology; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Extracellular Space; Female; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Visual Cortex | 2008 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Death; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Antagonists; Humans; Ischemic Preconditioning; Membrane Proteins; Nerve Tissue Proteins; Neurons; Piperidines; Protein Isoforms; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.
Topics: Adenosine Diphosphate; Animals; Corpus Striatum; Dizocilpine Maleate; Drug Interactions; Male; Memantine; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Nitro Compounds; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2009 |
[Determination of ifenprodil in human plasma using liquid chromatography with electrospray tandem mass spectrometry].
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature | 2008 |
Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Generalized; Excitatory Amino Acid Antagonists; Hand Strength; Learning; Memantine; Motor Activity; Orientation; Pentylenetetrazole; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2009 |
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamic Acid; Glycine; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Mice; Microinjections; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Piperidines; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Reference Standards; Sequence Homology, Amino Acid; Temperature; Xenopus laevis; Zinc | 2009 |
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus.
Topics: Analysis of Variance; Animals; Biophysics; Drug Combinations; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2009 |
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor.
Topics: Aminoglycosides; Animals; Binding Sites; Biophysical Phenomena; Carbon Isotopes; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Time Factors; Tritium; Xenopus laevis | 2008 |
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies.
Topics: Animals; Antipsychotic Agents; Binding Sites; Buffers; Ethanolamines; Haloperidol; Histidine; Ligands; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Oligopeptides; Oocytes; Piperidines; Protein Binding; Protein Refolding; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 2008 |
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats.
Topics: Analgesics; Animals; Behavior, Animal; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Immunohistochemistry; Injections, Spinal; Male; Nerve Compression Syndromes; Pain Measurement; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Calcium Chloride; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Membrane Potentials; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2009 |
Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis.
Topics: Adrenergic alpha-Antagonists; Amygdala; Animals; Butadienes; Cycloheximide; Electric Stimulation; Enzyme Inhibitors; Extinction, Psychological; Fear; In Vitro Techniques; Long-Term Synaptic Depression; Male; Microelectrodes; Mitogen-Activated Protein Kinases; Nitriles; Piperidines; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamine; Lithium Chloride; Male; Mice; Models, Animal; Motor Activity; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Time Factors | 2010 |
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat.
Topics: Amyloid beta-Protein Precursor; Animals; Axonal Transport; Axons; Brain; Brain Injuries; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Intermediate Filaments; Male; Neurons; Photomicrography; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Molecular determinants of multiple effects of nickel on NMDA receptor channels.
Topics: Animals; Binding Sites; Biophysical Phenomena; Cell Line, Transformed; Dose-Response Relationship, Drug; Electric Stimulation; Glutamic Acid; Humans; Membrane Potentials; Models, Molecular; Nickel; Oocytes; Patch-Clamp Techniques; Piperidines; Point Mutation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Spermine; Trace Elements; Transfection; Xenopus; Zinc | 2009 |
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Topics: Amino Acid Sequence; Animals; Cell Line; Conotoxins; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Point Mutation; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2009 |
Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Butadienes; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Locomotion; Male; Nitriles; Nucleus Accumbens; Piperidines; Psychomotor Performance; Rats; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Time Factors | 2009 |
Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses.
Topics: Analysis of Variance; Animals; Biophysics; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Drug Interactions; Electric Stimulation; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exocytosis; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Patch-Clamp Techniques; Phalloidine; Piperidines; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetanus Toxin; Thiazolidines | 2010 |
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Immobility Response, Tonic; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Paroxetine; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming | 2009 |
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Locomotion; Male; Neurons; Phencyclidine; Piperidines; Quinoxalines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2009 |
The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze.
Topics: Analysis of Variance; Animals; Avoidance Learning; Catheters, Indwelling; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fear; Injections, Intraventricular; Male; Maze Learning; Periaqueductal Gray; Piperidines; Rats; Rats, Wistar; Space Perception; Staining and Labeling; Valine | 2010 |
Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Excitatory Amino Acid Antagonists; Hexachlorocyclohexane; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2009 |
Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors.
Topics: Animals; Animals, Newborn; Binding Sites; Female; Handling, Psychological; Limbic System; Male; Piperidines; Protein Subunits; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sex Factors | 2009 |
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Cells, Cultured; Hyperalgesia; Immunohistochemistry; Mice; Pain; Pain Measurement; Pain Threshold; Piperidines; Random Allocation; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Time Factors | 2010 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents.
Topics: Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kinetics; Piperidines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Temperature | 2010 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium.
Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2011 |
Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil.
Topics: Amination; Aniline Compounds; Bromine Compounds; Catalysis; Cell Line; Copper; Ethanolamine; Humans; Piperidines; Receptors, N-Methyl-D-Aspartate | 2010 |
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.
Topics: Aniline Compounds; Animals; Cell Line; Cricetinae; Drug Evaluation, Preclinical; Electrophysiology; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Histamine H3 Antagonists; Humans; Imidazoles; Isothiuronium; Microscopy, Fluorescence; Oocytes; Patch-Clamp Techniques; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Thiourea; Xanthenes; Xenopus laevis | 2010 |
Polyaminergic agents modulate contextual fear extinction in rats.
Topics: Animals; Biguanides; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine | 2010 |
Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists.
Topics: Animals; Benzazepines; Binding Sites; Cell Line; Drug Design; Drug Evaluation, Preclinical; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2010 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; HMGB1 Protein; Humans; Interleukin-1beta; Kainic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2010 |
Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2010 |
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.
Topics: Animals; Binding, Competitive; Cells, Cultured; Humans; Mice; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate | 2010 |
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; Kaplan-Meier Estimate; Male; Mice; Motor Activity; Organ Size; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Sex Factors; Treatment Outcome | 2010 |
Rapid activation of dormant presynaptic terminals by phorbol esters.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calcium; Carbazoles; Carcinogens; Cells, Cultured; Colforsin; Dizocilpine Maleate; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Indoles; Maleimides; Neurons; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Piperidines; Presynaptic Terminals; Rats; Sucrose; Sweetening Agents; Vesicular Glutamate Transport Protein 1 | 2010 |
NMDA receptor contributions to visual contrast coding.
Topics: Animals; Contrast Sensitivity; Dizocilpine Maleate; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Guinea Pigs; In Vitro Techniques; Light; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Photic Stimulation; Piperidines; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Visual Perception | 2010 |
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain.
Topics: Analysis of Variance; Animals; Blotting, Western; Excitatory Amino Acid Antagonists; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Pain Measurement; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Temporomandibular Joint | 2011 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Hyperalgesia; Injections, Spinal; Isomerism; Ketamine; Male; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Animals, Newborn; Benzimidazoles; Biotinylation; Casein Kinase II; Cells, Cultured; Cerebral Cortex; Disks Large Homolog 4 Protein; Embryo, Mammalian; Endocytosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Models, Biological; Neurons; Patch-Clamp Techniques; PDZ Domains; Phosphorus Isotopes; Phosphorylation; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Subcellular Fractions; Synapses; Synaptophysin; Tetrodotoxin; Transfection; Tyrosine | 2010 |
NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters.
Topics: Amygdala; Animals; Behavior, Animal; Conditioning, Psychological; Cricetinae; Fear; Male; Mesocricetus; Microinjections; Piperidines; Receptors, N-Methyl-D-Aspartate | 2011 |
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.
Topics: Analgesics; Animals; Benzazepines; Humans; Mice; Microsomes, Liver; Neuralgia; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2010 |
Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Morphine; Narcotics; Piperidines; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2011 |
[NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats].
Topics: Animals; Avoidance Learning; Dimethyl Sulfoxide; ets-Domain Protein Elk-1; Extracellular Signal-Regulated MAP Kinases; Male; Maze Learning; Memory; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Gene Expression Regulation; Hyperalgesia; Indazoles; Male; Memantine; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organoplatinum Compounds; Oxaliplatin; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 2011 |
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Ketamine; Male; Mice; Mice, Nude; Piperidines; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2011 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Amyloid β peptide oligomers directly activate NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiological Phenomena; Female; Humans; Memantine; Neurons; Oocytes; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Xenopus laevis | 2011 |
Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats.
Topics: Age Factors; Animals; Drug Tolerance; Ethanol; Male; Motor Activity; Piperidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats.
Topics: Animals; Dizocilpine Maleate; Homocysteine; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2011 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury.
Topics: Animals; Apoptosis; Brain Ischemia; Drug Therapy, Combination; Flurbiprofen; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Stroke | 2011 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperalgesia; Indazoles; JNK Mitogen-Activated Protein Kinases; Male; Neuralgia; Neurons; Nitric Oxide Synthase Type I; Pain Measurement; Phenols; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord | 2011 |
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Electric Stimulation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Knockout; Models, Biological; N-Methylaspartate; Piperidines; Pyramidal Cells; Pyridines; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Thiazoles; Time Factors; Visual Cortex | 2011 |
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Blotting, Western; Calcium; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Immunohistochemistry; Long-Term Potentiation; Mice; Microscopy, Confocal; Neurons; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses | 2011 |
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients.
Topics: Alcoholism; Analysis of Variance; Asian People; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Haloperidol; Humans; Middle Aged; Outpatients; Paroxetine; Piperidines; Retrospective Studies; Risk; Secondary Prevention; Treatment Outcome | 2011 |
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Topics: 2-Hydroxyphenethylamine; Allosteric Regulation; Animals; Binding Sites; Crystallography, X-Ray; Disulfides; Movement; Neuroprotective Agents; Piperidines; Protein Multimerization; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2011 |
Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons.
Topics: Animals; Cations, Divalent; Chelating Agents; Ethylenediamines; Excitatory Amino Acid Antagonists; Female; Ion Channel Gating; Magnesium; Male; Mice; Neocortex; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Zinc | 2011 |
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Long-Term Synaptic Depression; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Potentials; Visual Cortex; Zinc | 2011 |
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Mice; N-Methylaspartate; Pain Measurement; Phosphorylation; Piperidines; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synapses | 2011 |
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.
Topics: Action Potentials; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain Waves; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electroencephalography; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Flavones; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Piperazines; Piperidines; Pregnanolone; Presenilin-1; Receptors, N-Methyl-D-Aspartate; Serotonin; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2011 |
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists.
Topics: Amino Alcohols; Binding Sites; Dizocilpine Maleate; Drug Design; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Ligands; Molecular Structure; Molecular Targeted Therapy; N-Methylaspartate; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2011 |
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Cerebral Cortex; Disks Large Homolog 4 Protein; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Guanylate Kinases; Immunoprecipitation; In Vitro Techniques; Locomotion; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Patch-Clamp Techniques; Phenols; Piperidines; Protein Binding; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Transfection | 2011 |
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes.
Topics: Animals; Area Under Curve; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Interleukin-1beta; Lipopolysaccharides; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Exchanging ATPase | 2011 |
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.
Topics: Animals; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Patch-Clamp Techniques; Piperidines; Protein Subunits; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2011 |
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala.
Topics: Amygdala; Animals; Conditioning, Psychological; Cysteine Proteinase Inhibitors; DNA Helicases; Excitatory Amino Acid Antagonists; Fear; Immunoblotting; Lactones; Male; Memory; Memory, Long-Term; N-Methylaspartate; Neuronal Plasticity; Piperidines; Proteasome Endopeptidase Complex; Proteolysis; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors; Ubiquitin; Ubiquitination | 2011 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
Ifenprodil for the treatment of flashbacks in female posttraumatic stress disorder patients with a history of childhood sexual abuse.
Topics: Adrenergic alpha-Antagonists; Adult; Adult Survivors of Child Abuse; Child; Child Abuse, Sexual; Female; Humans; Life Change Events; Mental Recall; Middle Aged; Piperidines; Receptors, N-Methyl-D-Aspartate; Stress Disorders, Post-Traumatic; Treatment Outcome | 2012 |
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.
Topics: Analysis of Variance; Animals; Biotinylation; Dendrites; Electrophysiology; Extinction, Psychological; Heroin Dependence; Long-Term Potentiation; Microscopy, Confocal; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission | 2011 |
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
Topics: Animals; Cell Culture Techniques; Cell Survival; Culture Media; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Memantine; Microscopy, Confocal; Neurons; Neuroprotective Agents; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Synapses; tat Gene Products, Human Immunodeficiency Virus; Transfection | 2012 |
Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates.
Topics: Cells, Cultured; Fluorescent Dyes; HEK293 Cells; Humans; Microscopy, Confocal; Molecular Structure; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2012 |
A critical role for GluN2B-containing NMDA receptors in cortical development and function.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Immunosuppressive Agents; Mice; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Sirolimus; Social Behavior; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Valine | 2011 |
Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels.
Topics: Amygdala; Animals; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Excitatory Postsynaptic Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Synaptic Transmission | 2012 |
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Male; Neuralgia; Pain Measurement; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries | 2012 |
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Antagonists; Glutamic Acid; In Situ Hybridization; Male; MAP Kinase Signaling System; Phosphorylation; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2012 |
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.
Topics: Allosteric Regulation; Animals; Female; Ligands; Mice; Molecular Dynamics Simulation; Piperidines; Protein Binding; Protein Interaction Mapping; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2012 |
Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Humans; Male; Mutagenesis, Site-Directed; Piperidines; Protein Structure, Tertiary; Proteolysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Analysis, Protein; Time Factors; Tissue Plasminogen Activator | 2012 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.
Topics: Animals; Calcium; Chelating Agents; Egtazic Acid; Inositol 1,4,5-Trisphosphate Receptors; Nerve Growth Factor; Neurites; Neurons; PC12 Cells; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Vasodilator Agents | 2012 |
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.
Topics: Animals; Apoptosis; Cerebral Cortex; Coculture Techniques; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Huntington Disease; Memantine; Mice; Mice, Transgenic; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2012 |
Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs.
Topics: Algorithms; Animals; Axons; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Kinetics; Ligands; Mice; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Zinc | 2012 |
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Membrane; Creatine; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoenzymes; Male; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2012 |
Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil.
Topics: Amino Acid Sequence; Animals; Female; Molecular Sequence Data; Piperidines; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Xenopus laevis | 2012 |
On mechanism of allosteric modulation of NMDA receptor via amino-terminal domains.
Topics: Allosteric Regulation; Binding Sites; Excitatory Amino Acid Antagonists; Humans; Piperidines; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate | 2012 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger | 2012 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Male; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Pilocarpine; Piperidines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Compounds | 2013 |
Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Humans; Models, Neurological; Neuroprotective Agents; Piperidines; Piroxicam; Receptors, N-Methyl-D-Aspartate; Stroke | 2012 |
Ifenprodil effects on GluN2B-containing glutamate receptors.
Topics: Binding Sites; Glutamic Acid; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kinetics; Ligands; Neuroprotective Agents; Piperidines; Polyamines; Protons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Zinc | 2012 |
Properties of doublecortin expressing neurons in the adult mouse dentate gyrus.
Topics: Action Potentials; Animals; Animals, Newborn; Calbindin 2; Cell Movement; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Female; Gene Expression Regulation; Green Fluorescent Proteins; Kinetics; Male; Mice; Microtubule-Associated Proteins; Neural Cell Adhesion Molecule L1; Neurogenesis; Neurons; Neuropeptides; Piperidines; Promoter Regions, Genetic; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein G; Sialic Acids; Synapses | 2012 |
Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating.
Topics: Allosteric Regulation; Animals; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors | 2013 |
Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.
Topics: Amygdala; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; HEK293 Cells; Humans; Long-Term Potentiation; Male; Neurons; Piperidines; Protein Multimerization; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Synapses | 2013 |
Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.
Topics: Animals; Cells, Cultured; Hippocampus; HIV-1; Imidazoles; LDL-Receptor Related Proteins; Neurons; Piperazines; Piperidines; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptophysin; tat Gene Products, Human Immunodeficiency Virus | 2013 |
Ifenprodil for emotional incontinence in patients with vascular dementia: two case reports.
Topics: Affective Symptoms; Aged; Crying; Dementia, Vascular; Excitatory Amino Acid Antagonists; Humans; Laughter; Male; Piperidines; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2013 |
Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.
Topics: Amygdala; Animals; Anisomycin; Association Learning; Excitatory Amino Acid Antagonists; Fear; Male; Memory; Piperidines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2013 |
Synthesis and in vitro characterisation of ifenprodil-based fluorescein conjugates as GluN1/GluN2B N-Methyl-D-aspartate receptor antagonists.
Topics: Animals; Binding Sites; Brain; Calcium; Cells, Cultured; Fluorescein; HEK293 Cells; Humans; Male; Mice; Models, Molecular; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Radiography; Receptors, N-Methyl-D-Aspartate | 2013 |
Old drug ifenprodil, new hope for PTSD with a history of childhood abuse.
Topics: Adolescent; Child; Child Abuse, Sexual; Excitatory Amino Acid Antagonists; Female; Humans; Piperidines; Stress Disorders, Post-Traumatic | 2013 |
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation | 2013 |
Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Cerebral Cortex; Choice Behavior; Conditioning, Operant; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Food Preferences; Goals; Male; Memory; Mental Recall; Motivation; Nerve Tissue Proteins; Neurons; Piperidines; Rats; Rats, Long-Evans; Satiety Response | 2013 |
Kainate-induced calcium overload of cortical neurons in vitro: Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain.
Topics: Adamantane; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Neurons; Ouabain; Patch-Clamp Techniques; Piperidines; Pregnancy; Rats; Rats, Wistar; Receptors, AMPA | 2013 |
Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.
Topics: Animals; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Electrodes, Implanted; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperazines; Piperidines; Polyamines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2013 |
Effects of ifenprodil on the antidepressant-like activity of NMDA ligands in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Ligands; Male; Mice; Motor Activity; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Treatment Outcome | 2013 |
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.
Topics: Alcohol Deterrents; Alcohol Drinking; Amygdala; Animals; Avoidance Learning; Bacterial Proteins; Cerebral Cortex; Conditioning, Operant; Drug Resistance; Ethanol; Excitatory Amino Acid Antagonists; Halorhodopsins; Luminescent Proteins; Male; Nerve Tissue Proteins; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Quinine; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Small Interfering; Valine | 2013 |
Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus.
Topics: Animals; Binding Sites; Hippocampus; Ketamine; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate | 2013 |
Deletion of the N-terminal domain alters the ethanol inhibition of N-methyl-D-aspartate receptors in a subunit-dependent manner.
Topics: Central Nervous System Depressants; Ethanol; HEK293 Cells; Humans; Patch-Clamp Techniques; Piperidines; Protein Structure, Quaternary; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate | 2013 |
The basolateral amygdala is critical for learning about neutral stimuli in the presence of danger, and the perirhinal cortex is critical in the absence of danger.
Topics: Acoustic Stimulation; Amygdala; Animals; Association Learning; Conditioning, Classical; Environment; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; GABA-A Receptor Agonists; Male; Muscimol; Photic Stimulation; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar | 2013 |
Ifenprodil for the treatment of flashbacks in adolescent female posttraumatic stress disorder patients with a history of abuse.
Topics: Adolescent; Bullying; Child; Child Abuse, Sexual; Female; Humans; Neuroprotective Agents; Piperidines; Stress Disorders, Post-Traumatic; Treatment Outcome; Young Adult | 2013 |
The preventive effect of NR2B and NR2D-containing NMDAR antagonists on Aβ-induced LTP disruption in the dentate gyrus of rats.
Topics: Amyloid beta-Peptides; Animals; Dentate Gyrus; Diazonium Compounds; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Peptide Fragments; Piperidines; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2013 |
Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist.
Topics: Animals; Binding Sites; Biological Availability; Biotransformation; Cattle; Chromatography, Liquid; Female; Male; Mass Spectrometry; Microsomes, Liver; Phenol; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serum Albumin | 2014 |
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Motor Activity; Piperidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Social Behavior | 2014 |
Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.
Topics: Analysis of Variance; Animals; Bacterial Proteins; Conditioning, Classical; Disease Models, Animal; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Exploratory Behavior; Extinction, Psychological; Fear; GABA Agonists; Generalization, Psychological; Glutamate Decarboxylase; Guanylate Kinases; Hippocampus; Luminescent Proteins; Maze Learning; Membrane Proteins; Memory; Mice; Mice, Transgenic; Nipecotic Acids; Panic Disorder; Piperidines; Proto-Oncogene Proteins c-fos; Receptor, trkC; Tiagabine; Vesicular Glutamate Transport Proteins | 2013 |
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
Topics: Acute Disease; Animals; Antineoplastic Agents; Behavior, Animal; Cold Temperature; Diet; Glutamic Acid; Hyperalgesia; Immunoblotting; Magnetic Resonance Spectroscopy; Male; Metabolomics; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Piperidines; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Vasodilator Agents | 2013 |
Preference for high-fat diet is developed by young Swiss CD1 mice after short-term feeding and is prevented by NMDA receptor antagonists.
Topics: Animals; Blood Glucose; Diet, High-Fat; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Food Preferences; Ketamine; Male; Mice; Mice, Inbred Strains; Piperidines; Receptors, N-Methyl-D-Aspartate | 2014 |
Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors.
Topics: Animals; Anticonvulsants; Antioxidants; Binding, Competitive; Chemistry Techniques, Synthetic; Hippocampus; In Vitro Techniques; Indoles; Ligands; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Molecular Docking Simulation; Molecular Structure; Piperidines; Receptors, N-Methyl-D-Aspartate; Small Molecule Libraries | 2014 |
Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus.
Topics: Adult Stem Cells; Animals; Cell Proliferation; Hippocampus; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Piperidines; Receptors, N-Methyl-D-Aspartate | 2014 |
In vitro and in vivo biotransformation of WMS-1410, a potent GluN2B selective NMDA receptor antagonist.
Topics: Animals; Benzazepines; Biotransformation; Catechols; Hydroxylation; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Microsomes, Liver; Phenol; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.
Topics: Animals; Dimerization; Excitatory Amino Acid Antagonists; Glutamic Acid; HEK293 Cells; Humans; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sulfonamides; Trace Elements; Xenopus laevis; Zinc | 2014 |
Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Disease; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation; GTPase-Activating Proteins; Hippocampus; Hypercapnia; Hypoxia; Learning Disabilities; Lovastatin; Male; MAP Kinase Signaling System; Maze Learning; Membrane Microdomains; Memory Disorders; Neuropeptides; Nootropic Agents; Piperidines; Pulmonary Disease, Chronic Obstructive; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spatial Learning; Synaptosomes | 2014 |
Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dynorphins; Memantine; Mossy Fibers, Hippocampal; Neuropeptide Y; Phenols; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Up-Regulation | 2014 |
Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naphthalenes; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrrolidines; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate | 2014 |
Age and activation determines the anticonvulsant effect of ifenprodil in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Male; Pentylenetetrazole; Piperidines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2014 |
An anti-immobility effect of spermine in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermine; Swimming | 2014 |
GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids; Male; Maze Learning; Nerve Tissue Proteins; Nervous System Diseases; Piperidines; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Somatosensory Cortex; Time Factors | 2014 |
D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2014 |
Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Male; Neuralgia; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Spinal Cord Dorsal Horn; Synapses; Synaptic Transmission | 2014 |
[Effects of mild hypothermia plus ifenprodil on apoptosis inducing factor translocation after global cerebral ischemia-reperfusion in rats].
Topics: Animals; Apoptosis Inducing Factor; Brain Ischemia; Disease Models, Animal; Hypothermia, Induced; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reperfusion | 2014 |
Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice.
Topics: Affective Symptoms; Aggression; Animals; Animals, Newborn; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Gene Expression Regulation; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Piperidines; Prepulse Inhibition; Random Allocation; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Social Isolation; Swimming; Synaptosomes | 2015 |
Variations in the stimulus salience of cocaine reward influences drug-associated contextual memory.
Topics: Aminoacetonitrile; Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Memory; Mice, Inbred C57BL; Nitric Oxide Synthase Type I; Piperidines; Receptors, N-Methyl-D-Aspartate; Reward | 2016 |
Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
Topics: Acetamides; Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Piperidines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Thiadiazoles | 2015 |
Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Beclomethasone; Calcium; Cerebral Cortex; Cognition; Cytosol; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potential, Mitochondrial; Mice, Transgenic; Mitochondria; Neurons; Piperidines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotenone | 2015 |
The effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Synergism; Fluoxetine; Imipramine; Mice; Morpholines; Piperidines; Reboxetine; Swimming; Thiazepines | 2014 |
NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Afferent Pathways; Animals; Aspartic Acid; Benzimidazoles; Calcium; Excitatory Amino Acid Antagonists; In Vitro Techniques; Piperidines; Pregnenolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Sulfonamides; Vagus Nerve | 2015 |
Piroxicam inhibits NMDA receptor-mediated excitotoxicity through allosteric inhibition of the GluN2B subunit: an in silico study elucidating a novel mechanism of action of the drug.
Topics: Allosteric Site; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Cells, Cultured; Humans; Ligands; Models, Biological; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Piperidines; Piroxicam; Protein Binding; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 2014 |
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; CD40 Antigens; Cell Proliferation; Immunoglobulin G; Immunoglobulin M; Interferon-gamma; Interleukin-10; Intermediate-Conductance Calcium-Activated Potassium Channels; Kv1.3 Potassium Channel; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Receptors, Antigen, B-Cell; Receptors, N-Methyl-D-Aspartate; Toll-Like Receptor 4 | 2014 |
Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse.
Topics: Alanine Transaminase; Amyloid beta-Peptides; Analysis of Variance; Animals; Aspartic Acid; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred BALB C; Nerve Net; Neuronal Plasticity; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Pyruvic Acid; Synapses | 2015 |
Spermine reverses lipopolysaccharide-induced memory deficit in mice.
Topics: Analysis of Variance; Animals; Cytokines; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Exploratory Behavior; Lipopolysaccharides; Male; Memory Disorders; Mice; Piperidines; Recognition, Psychology; Spermine | 2015 |
[³H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study.
Topics: Adolescent; Adult; Aged; Alcoholics; Alcoholism; Autoradiography; Brain; Female; Humans; Male; Middle Aged; Nucleus Accumbens; Piperidines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Young Adult | 2015 |
The NR2B antagonist, ifenprodil, corrects the l-DOPA-induced deficit of bilateral movement and reduces c-Fos expression in the subthalamic nucleus of hemiparkinsonian rats.
Topics: Animals; Antiparkinson Agents; Brain; Forelimb; Levodopa; Male; Motor Activity; Parkinsonian Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Subthalamic Nucleus | 2015 |
Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex.
Topics: Animals; Cerebral Cortex; Ethanol; Female; Male; Maternal Exposure; Patch-Clamp Techniques; Piperidines; Protein Binding; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2015 |
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine | 2015 |
NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Death; Epilepsy; Excitatory Amino Acid Antagonists; Gliosis; Glutathione Peroxidase; Hippocampus; Kindling, Neurologic; Male; Malondialdehyde; Mice, Inbred C57BL; Neurons; Oxidative Stress; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase | 2015 |
Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.
Topics: Animals; Dendrites; Diazonium Compounds; Glutamic Acid; Mice; N-Methylaspartate; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2015 |
GluN2B-containing N-methyl-D-aspartate receptors compensate for the inhibitory control of synaptic plasticity during the early critical period in the rat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Bicuculline; Diazepam; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression Regulation, Developmental; Long-Term Potentiation; Male; Neural Inhibition; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2015 |
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
Topics: Animals; Binding Sites; Brain; Dizocilpine Maleate; Molecular Docking Simulation; Pentamidine; Piperazine; Piperazines; Piperidines; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2015 |
A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.
Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Molecular Sequence Data; Piperidines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Zinc | 2015 |
Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats.
Topics: Abdominal Muscles; Afferent Pathways; Animals; Central Amygdaloid Nucleus; Hyperalgesia; Male; Nociception; Pain Measurement; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sincalide; Vagotomy; Vagus Nerve; Visceral Pain | 2015 |
NMDA receptor binding is reduced within mesocorticolimbic regions following chronic inhalation of toluene in adolescent rats.
Topics: Animals; Animals, Newborn; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Excitatory Amino Acid Agents; Gene Expression; Limbic System; Male; Nicotinic Agonists; Piperidines; Protein Binding; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Solvents; Somatosensory Cortex; Toluene; Tritium | 2015 |
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
Topics: Animals; Carrier Proteins; Cells, Cultured; Central Nervous System Depressants; Electric Capacitance; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Homer Scaffolding Proteins; Kainic Acid; Membrane Potentials; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate | 2016 |
Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling.
Topics: Animals; Astrocytes; Dentate Gyrus; Encephalomyelitis, Autoimmune, Experimental; Humans; Learning; Memory; Mice; Multiple Sclerosis; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold.
Topics: Benzazepines; Binding Sites; Humans; Kinetics; Molecular Docking Simulation; Phenols; Piperidines; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Tritium | 2016 |
A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
Topics: Adrenergic alpha-Antagonists; Allosteric Regulation; Amino Acid Substitution; Animals; Binding Sites; Computational Biology; Drugs, Investigational; Expert Systems; Humans; Imidazoles; Ligands; Membrane Transport Modulators; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutation; Oxadiazoles; Piperidines; Protein Interaction Domains and Motifs; Protein Subunits; Pyridazines; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Xenopus Proteins | 2016 |
Ifenprodil for prolonged spinal blockades of motor function and nociception in rats.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Nerve Block; Nociception; Piperidines; Rats; Rats, Sprague-Dawley | 2016 |
Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca2+ channels, and calcineurin.
Topics: Animals; Behavior, Animal; Calcineurin; Calcium Channels, L-Type; Hippocampus; Long-Term Potentiation; Male; Memory, Long-Term; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2016 |
The Combination of Marketed Antagonists of α1b-Adrenergic and 5-HT2A Receptors Inhibits Behavioral Sensitization and Preference to Alcohol in Mice: A Promising Approach for the Treatment of Alcohol Dependence.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cyproheptadine; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Prazosin; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists | 2016 |
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.
Topics: Animals; Apoproteins; Cryoelectron Microscopy; Crystallography, X-Ray; Electrophysiology; Ion Channel Gating; Ligands; Models, Molecular; Piperidines; Protein Conformation; Protein Multimerization; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate | 2016 |
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Disease Susceptibility; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Kainic Acid; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1 Type I; Receptors, N-Methyl-D-Aspartate; Seizures, Febrile | 2016 |
Ifenprodil Attenuates Methamphetamine-Induced Behavioral Sensitization and Activation of Ras-ERK-∆FosB Pathway in the Caudate Putamen.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Extracellular Signal-Regulated MAP Kinases; Genes, ras; Male; MAP Kinase Signaling System; Methamphetamine; Mice, Inbred C57BL; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Putamen; Receptors, N-Methyl-D-Aspartate | 2016 |
An appetitive experience after fear memory destabilization attenuates fear retention: involvement GluN2B-NMDA receptors in the Basolateral Amygdala Complex.
Topics: Animals; Appetitive Behavior; Basolateral Nuclear Complex; Excitatory Amino Acid Antagonists; Fear; Male; Memory Consolidation; Piperidines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retention, Psychology | 2016 |
Ifenprodil attenuates the acquisition and expression of methamphetamine-induced behavioral sensitization and activation of Ras-ERK1/2 cascade in the caudate putamen.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; MAP Kinase Signaling System; Methamphetamine; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; Piperidines; Putamen; Receptors, N-Methyl-D-Aspartate | 2016 |
Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers.
Topics: Adenosine Triphosphate; Allosteric Regulation; Amino Acids; Animals; Binding Sites; Cross-Linking Reagents; Ligands; Models, Molecular; Mutation; Piperidines; Protein Binding; Protein Conformation; Protein Multimerization; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus laevis; Xenopus Proteins; Zinc | 2016 |
Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.
Topics: Animals; Behavior, Animal; Choice Behavior; Cycloserine; Delay Discounting; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Impulsive Behavior; Ketamine; Ligands; Male; Memantine; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 2017 |
Effect of the ifenprodil administered into rostral anterior cingulate cortex on pain-related aversion in rats with bone cancer pain.
Topics: Animals; Avoidance Learning; Bone Neoplasms; Cancer Pain; Conditioning, Psychological; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gyrus Cinguli; Male; Pain Threshold; Piperidines; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2016 |
Induction and Blockade of Adolescent Cocaine-Induced Habits.
Topics: Animals; Cocaine; Conditioning, Operant; Decision Making; Dendritic Spines; Drug-Seeking Behavior; Goals; Habits; Imatinib Mesylate; Male; Mice; Mice, Inbred C57BL; Piperidines; Prefrontal Cortex; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 2017 |
Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development.
Topics: Analysis of Variance; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Excitatory Amino Acid Antagonists; Female; Male; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Long-Evans; Sex Factors; Social Behavior; Time Factors; Vocalization, Animal | 2017 |
Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Topics: 2-Hydroxyphenethylamine; Animals; Binding Sites; Blotting, Western; Crystallography; Hydrogen Bonding; Piperidines; Protein Structure, Quaternary; Receptors, N-Methyl-D-Aspartate; Sf9 Cells; Spodoptera; Xenopus laevis; Zinc | 2016 |
Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.
Topics: Amyloid beta-Peptides; Animals; Antimetabolites; Cycloserine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Locomotion; Male; Maze Learning; N-Methylaspartate; Nesting Behavior; Neurotoxicity Syndromes; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Signal Transduction; Synapses | 2017 |
Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Kainic Acid; Mice; Mice, Inbred BALB C; Mice, Knockout; Neuroglia; Neurons; Piperidines; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Memory consolidation within the central amygdala is not necessary for modulation of cerebellar learning.
Topics: Animals; Anisomycin; Central Amygdaloid Nucleus; Cerebellum; Conditioning, Classical; Conditioning, Eyelid; Dichlororibofuranosylbenzimidazole; Electromyography; Excitatory Amino Acid Antagonists; Male; Memory Consolidation; Piperidines; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Mice; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2017 |
GluN2B Subunit Labeling with Fluorescent Probes and High-Resolution Live Imaging.
Topics: Calcium; Fluorescent Dyes; Microscopy, Confocal; Piperidines; Receptors, N-Methyl-D-Aspartate | 2017 |
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclin-Dependent Kinase 5; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Neurons; Phosphopyruvate Hydratase; Piperidines; Pyridazines; Sensory Deprivation; Visual Cortex; Visual Pathways | 2018 |
Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Lithium Chloride; Male; Pilocarpine; Piperidines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2018 |
Detection of nanocarrier potentiation on drug induced phospholipidosis in cultured cells and primary hepatocyte spheroids by high content imaging and analysis.
Topics: Animals; Dose-Response Relationship, Drug; Drug Carriers; Graphite; Hep G2 Cells; Hepatocytes; Humans; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanoparticles; Phospholipids; Piperidines; Primary Cell Culture; RAW 264.7 Cells; Risk Assessment; Silicon Dioxide; Spheroids, Cellular | 2018 |
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation.
Topics: Analgesia; Animals; Butadienes; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Ketamine; Male; Mice, Inbred C57BL; Morphine; Nitriles; Phosphorylation; Piperidines; Pruritus; Receptors, N-Methyl-D-Aspartate | 2018 |
Id1/NR2B Receptor Pathway Regulates Rat Cochlear Sensory Epithelial Cell Survival after Radiation.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cochlea; Epithelial Cells; Excitatory Amino Acid Antagonists; Inhibitor of Differentiation Protein 1; Organ of Corti; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; RNA, Small Interfering; S Phase; Transfection | 2018 |
Agmatine preferentially antagonizes GluN2B-containing N-methyl-d-aspartate receptors in spinal cord.
Topics: Agmatine; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Nociception; Piperidines; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Spinal Cord Dorsal Horn | 2019 |
Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.
Topics: Animals; Brain Injuries; Excitatory Amino Acid Antagonists; Gene Knockdown Techniques; Green Fluorescent Proteins; Larva; Neural Pathways; Neurogenesis; Neuronal Plasticity; Neurons; Photic Stimulation; Piperidines; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Synapses; Visual Perception; Xenopus laevis | 2019 |
Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
Topics: Age Factors; Animals; Hippocampus; Ketamine; Male; Mice; Piperidines; Prefrontal Cortex; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Social Behavior; Stress, Psychological | 2019 |
Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Hyperalgesia; Male; Nociceptive Pain; Nociceptors; Pain Measurement; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Streptozocin | 2019 |
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning.
Topics: Cell Line, Tumor; Cell Survival; Drug Discovery; Drug Repositioning; Gene Expression Profiling; Genes, Reporter; Genome, Human; Genomics; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Piperidines; Prostatic Neoplasms; Proteome; Proteomics | 2019 |
Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold.
Topics: Animals; Benzazepines; Biotransformation; Glucuronides; Humans; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenol; Piperidines; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 2019 |
Excitatory/inhibitory balance across ontogeny contributes to age-specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditioning, Classical; Ethanol; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Agonists; Isoxazoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Taste Perception | 2019 |
Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging.
Topics: Aging; Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dithiothreitol; Male; Models, Animal; Neuronal Plasticity; Oxidants; Oxidation-Reduction; Piperidines; Protein Subunits; Pyramidal Cells; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2019 |
Suppression of Cerebral Ischemia/Reperfusion Injury by Efficient Release of Encapsulated Ifenprodil From Liposomes Under Weakly Acidic pH Conditions.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Disease Models, Animal; Hydrogen-Ion Concentration; Liposomes; Male; Neuroprotective Agents; Permeability; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Solubility; Water | 2019 |
Postsynaptic GluN2B-containing NMDA receptors contribute to long-term depression induction in medial vestibular nucleus neurons of juvenile rats.
Topics: Animals; Diazonium Compounds; Female; Long-Term Synaptic Depression; Phenols; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Sulfonamides; Vestibular Nuclei | 2020 |
Ifenprodil Attenuates Methamphetamine-Induced Behavioral Sensitization Through the GluN2B-PP2A-AKT Cascade in the Dorsal Striatum of Mice.
Topics: Animals; Behavior, Addictive; Corpus Striatum; Male; Methamphetamine; Mice, Inbred C57BL; Piperidines; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance-Related Disorders | 2020 |
Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats.
Topics: Animals; Antidepressive Agents; Cytokines; Depression; Excitatory Amino Acid Antagonists; Hippocampus; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Direct administration of ifenprodil and citalopram into the nucleus accumbens inhibits cue-induced nicotine seeking and associated glutamatergic plasticity.
Topics: Animals; Citalopram; Cues; Dendritic Spines; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Neuronal Plasticity; Neurons; Nicotine; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Self Administration | 2020 |
Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diabetic Neuropathies; Formaldehyde; Kv Channel-Interacting Proteins; Male; Microglia; Nerve Tissue Proteins; Neuralgia; Piperidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; Spinal Cord | 2021 |
Thalamic nucleus reuniens regulates fear memory destabilization upon retrieval.
Topics: Amygdala; Animals; Anisomycin; CA1 Region, Hippocampal; Clonidine; Cognition; Cysteine Proteinase Inhibitors; Early Growth Response Protein 1; Excitatory Amino Acid Antagonists; Fear; GABA-A Receptor Agonists; Lactones; Memory; Midline Thalamic Nuclei; Muscimol; Neurons; Piperidines; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Topics: Antifibrinolytic Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Idiopathic Pulmonary Fibrosis; Models, Molecular; Molecular Structure; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 2021 |
A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects.
Topics: Animals; Conotoxins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Locomotion; Male; Mice; Morphine Dependence; Naloxone; Piperidines; Receptors, N-Methyl-D-Aspartate; Spatial Memory | 2021 |
Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization.
Topics: Animals; Behavior, Animal; Cocaine; Excitatory Amino Acid Antagonists; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Nucleus Accumbens; Piperidines; Protein Kinase Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2021 |
Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Ethanol; Female; gamma-Aminobutyric Acid; Glutamates; Male; Piperidines; Rats | 2021 |
Deconstruction - Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.
Topics: Adrenergic alpha-Antagonists; Allosteric Regulation; Animals; Benzazepines; Benzoxazoles; Binding Sites; Excitatory Amino Acid Antagonists; Humans; Kinetics; Molecular Docking Simulation; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Tritium; Xenopus laevis | 2021 |
Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid Hemorrhage.
Topics: Animals; Blood-Brain Barrier; Glutamic Acid; Humans; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Subarachnoid Hemorrhage | 2021 |
DMV extrasynaptic NMDA receptors regulate caloric intake in rats.
Topics: Animals; Appetite Regulation; Diet, High-Fat; Eating; Energy Intake; Excitatory Amino Acid Antagonists; Gastric Emptying; Gastrointestinal Motility; Medulla Oblongata; Memantine; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Stomach; Vagus Nerve | 2021 |
Biophysical and synaptic properties of NMDA receptors in the lateral habenula.
Topics: Animals; Entopeduncular Nucleus; Excitatory Amino Acid Antagonists; Habenula; Hypothalamic Area, Lateral; Long-Term Potentiation; Mice; Neural Pathways; Neurons; Optogenetics; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Sulfonamides; Synapses; Ventral Tegmental Area | 2021 |
Regulation of learned fear expression through the MgN-amygdala pathway.
Topics: Acoustic Stimulation; Amygdala; Animals; Conditioning, Classical; Extinction, Psychological; Fear; Fluorescent Antibody Technique; Geniculate Bodies; Hylobatidae; Male; Neural Pathways; Optogenetics; Piperidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2021 |
Geniposide attenuates postischemic long-term potentiation via GluN2A.
Topics: Animals; Apoptosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; In Vitro Techniques; Infarction, Middle Cerebral Artery; Iridoids; Long-Term Potentiation; Neurons; Oxidants; PC12 Cells; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2021 |
A Combinatorial CRISPR-Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Proliferation; CRISPR-Cas Systems; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Piperidines; Sorafenib; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Sigma receptor ligands haloperidol and ifenprodil attenuate hypoxia induced dopamine release in rat striatum.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Haloperidol; Hypoxia; Ligands; Nomifensine; Ouabain; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2022 |