ifenprodil and n-methylaspartate

ifenprodil has been researched along with n-methylaspartate in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (5.94)	18.7374
1990's	36 (35.64)	18.2507
2000's	36 (35.64)	29.6817
2010's	23 (22.77)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Nicklas, WJ; Zeevalk, GD	2
Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA	1
Harms, J; Woodward, JJ	1
Darles, G; Graham, D; Langer, SZ	1
Borosky, SA; Clissold, DB; Ferkany, JW; Goode, S; Karbon, EW; Patch, RJ; Pontecorvo, MJ	1
Heikkila, RE; Riordan, DE; Sonsalla, PK	1
Butler, TW; Chenard, BL; Fox, CB; Koe, BK; Prochniak, MA; Ronau, RT; Schmidt, AW; Shalaby, IA	1
Legendre, P; Westbrook, GL	1
Millan, MJ	1
Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B	1
Allen, J; Langer, SZ; Schoemaker, H	1
Miller, RJ; Reynolds, IJ	1
D'Angio, M; Scatton, B; Serrano, A	1
Jackson, A; Sanger, DJ	2
Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B	1
Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B	1
Beart, PM; Frandsen, A; Schousboe, A	1
Bordner, J; Butler, TW; Chambers, LK; Chenard, BL; Collins, MA; De Costa, DL; Ducat, MF; Dumont, ML; Fox, CB; Mena, EE	1
Kemp, JA; Ochu, E; Priestley, T	1
Williams, K	1
Carter, C; Fage, D; Nicolas, C	1
Carter, C; Fage, D; Voltz, C	1
Chavez-Noriega, L; Crona, J; Daggett, LP; Deal, C; Ellis, SB; Hess, SD; Johnson, EC; Lu, CC; Urrutia, A; Veliçelebi, G	1
Johnson, SW; Wu, YN	1
Carter, C; Fage, D; Klarica, M; Nankai, M	1
Basile, AS; Berlin, C; Huang, JM; Skolnick, P; Webster, D; Xie, C	1
Kirson, ED; Yaari, Y	1
Gisselmann, G; Gottmann, K; Hatt, H; Mehrle, A	1
Akerman, KE; Courtney, MJ; Engblom, AC; Kukkonen, JP	1
Blevins, T; Chandler, LJ; Mirshahi, T; Woodward, JJ	1
Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX	1
Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G	1
Dichter, MA; Kendrick, SJ; Wilcox, KS	1
Kemp, JA; Kew, JN	1
Gruol, DL; Netzeband, JG; Qiu, Z; Sweeney, DD	1
Allgaier, C; Feuerstein, TJ; Illes, P; Müller, D; Scheibler, P	1
Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L	1
Murali, SG; Sun, D	1
Lickteig, RL; Lovinger, DM; Popp, RL	1
Sharif, NA; Xu, SX	1
Brickley, SG; Cull-Candy, SG; Farrant, M; Misra, C	1
Bunney, BS; Shi, WX; Zhang, XX	1
Kolb, JE; Levine, ES	1
Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H	1
Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M	1
Shi, WX; Zhang, XX	1
Liu, X; Onaka, T; Yagi, K	1
Gibb, AJ; Green, GM	1
Lei, S; McBain, CJ	1
Cebere, A; Cebers, G; Liljequist, S; Wägner, A	1
Chen, N; Li, B; Luo, T; Murphy, TH; Otsu, Y; Raymond, LA	1
Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z	1
Breese, GR; Criswell, HE; Griffith, BL; Ming, Z	1
Dunn, RJ; Harvey-Girard, E	1
Baimbridge, KG; Fernandes, HB; Krebs, C; Raymond, LA; Sheldon, C	1
Ogonowski, AA; Smith, JB	1
Brickley, SG; Cull-Candy, SG; Mishina, M; Misra, C; Mok, MH	1
Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM	1
Gallagher, JP; Liu, J; McKernan, MG; Russell, RT; Shinnick-Gallagher, P; Xie, J; Zinebi, F	1
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA	1
André, VM; Cepeda, C; Flores-Hernández, J; Levine, MS; Lobo, MK; Mathern, GW; Nguyen, S; Starling, AJ; Vinters, HV	1
Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F	1
Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR	1
Baraban, SC; Calcagnotto, ME	1
Kiyosue, K; Nakayama, K; Taguchi, T	1
Mao, Y; Sun, X; Zang, S; Zhang, J	1
Baudry, M; Zhou, M	1
Bonnert, TP; Fradley, RL; Heavens, RP; Hunt, V; Lawrence, JM; Macaulay, A; Rosahl, TW; Treacey, P; Usala, M; Wafford, KA; Whiting, PJ; Wingrove, PB	1
Bear, MF; Lu, W; Malenka, RC; Morishita, W; Nicoll, RA; Smith, GB	1
Choi, HJ; Colwell, CS; Kim, YI	1
Bergersen, LH; Bezzi, P; Bhaukaurally, K; Domercq, M; Gundersen, V; Jourdain, P; Matute, C; Santello, M; Tonello, F; Volterra, A	1
Coserea, I; Fuchs, EC; Köhr, G; Monyer, H; Pawlak, V; Seeburg, PH; von Engelhardt, J	1
Ogata, M; Oh-Nishi, A; Saji, M; Satoh, SZ; Suzuki, N	1
Dehpour, AR; Ghasemi, M; Raza, M	1
Castellino, FJ; Geiger, JH; Liang, Z; Prorok, M; Sheng, Z	1
Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ	1
Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V	1
Bose, R; Parkinson, FE; Zamzow, CR	1
Demb, JB; Manookin, MB; Stafford, BK; Weick, M	1
Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M	1
Ashby, MC; Isaac, JT; Matta, JA; Roche, KW; Sanz-Clemente, A	1
Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X	1
Cirrito, JR; Goebel, WD; Holtzman, DM; Restivo, JL; Verges, DK	1
Höfner, G; Müller, A; Parsons, CG; Renukappa-Gutke, T; Wanner, KT	1
Biber, B; Björklund, U; Hansson, E; Lundborg, C; Westerlund, A	1
Helmstetter, FJ; Jarome, TJ; Kwapis, JL; Werner, CT	1
Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK	1
Berch, AM; Della-Pace, ID; Fighera, MR; Furian, AF; Oliveira, MS; Rambo, LM; Ribeiro, LR; Royes, LF; Schramm, VG; Silva, LF; Stamm, DN	1
Brittain, JM; Brittain, MK; Brustovetsky, N; Brustovetsky, T; Cummins, TR; Khanna, R	1
Barré, L; Becerril-Ortega, J; Buisson, A; Colloc'h, N; Dhilly, M; MacKenzie, ET; Nicole, O; Perrio, C	1
Morales, M; Spear, LP; Varlinskaya, EI	1
Chen, ZQ; Jiang, ZL; Li, X; Sun, L; Xu, LH; Yang, Y; Zhang, YF; Zhang, YY	1
Galvin, C; Lee, FS; Ninan, I	1
Antic, SD; Oikonomou, KD; Rich, MT; Short, SM; Singh, MB	1
Smothers, CT; Szumlinski, KK; Woodward, JJ; Worley, PF	1
Cheng, B; Huang, Y; Li, D; Liu, G; Shen, W; Su, J; Zhang, YX; Zhou, WX	1
Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M	1
Chen, L; Huang, M; Jiang, B; Li, S; Li, Y; Wang, L; Wang, X; Yang, Y; Zhang, X	1

Trials

1 trial(s) available for ifenprodil and n-methylaspartate

Article	Year
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cerebral cortex (New York, N.Y. : 1991), 2004, Volume: 14, Issue:6 Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Magnesium; Membrane Potentials; N-Methylaspartate; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Reference Values	2004

Other Studies

100 other study(ies) available for ifenprodil and n-methylaspartate

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil. Brain research. Developmental brain research, 1992, Feb-21, Volume: 65, Issue:2 Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina	1992
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2 Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1992
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation. European journal of pharmacology, 1992, Jan-21, Volume: 210, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1992
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies. European journal of pharmacology, 1992, Aug-03, Volume: 226, Issue:4 Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate	1992
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents. Brain research bulletin, 1991, Volume: 26, Issue:3 Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nimodipine; Piperidines; Postural Balance; Pyrimidines; Receptors, Opioid; Receptors, sigma; Seizures	1991
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2 Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase	1991
Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. Journal of medicinal chemistry, 1991, Volume: 34, Issue:10 Topics: Adrenergic alpha-Antagonists; Animals; Molecular Structure; N-Methylaspartate; Piperidines; Rats; Receptors, Adrenergic, alpha; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship	1991
Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism. Molecular pharmacology, 1991, Volume: 40, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Ibotenic Acid; Ion Channels; N-Methylaspartate; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents	1991
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat. European journal of pharmacology, 1991, Oct-15, Volume: 203, Issue:2 Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1991
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord	1990
Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity. Brain research, 1990, Jul-02, Volume: 522, Issue:1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Animals; Chick Embryo; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperidines; Quinoxalines; Retina	1990
Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex. European journal of pharmacology, 1990, Feb-06, Volume: 176, Issue:2 Topics: Animals; Aspartic Acid; Biogenic Polyamines; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains	1990
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Molecular pharmacology, 1989, Volume: 36, Issue:5 Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1989
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens. European journal of pharmacology, 1989, Mar-14, Volume: 162, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles	1989
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate. Neuropharmacology, 1989, Volume: 28, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste	1989
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism	1989
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction	1988
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord	1988
Blockade by polyamine NMDA antagonists related to ifenprodil of NMDA-induced synthesis of cyclic GMP, increases in calcium and cytotoxicity in cultured neurones. British journal of pharmacology, 1995, Volume: 114, Issue:7 Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; N-Methylaspartate; Neurons; Piperidines; Propanolamines; Receptors, N-Methyl-D-Aspartate	1995
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16 Topics: Animals; Cell Death; Cells, Cultured; Genes, fos; Hippocampus; Male; Mice; N-Methylaspartate; Nerve Degeneration; Piperidines; Rats; Structure-Activity Relationship	1995
Subtypes of NMDA receptor in neurones cultured from rat brain. Neuroreport, 1994, Sep-08, Volume: 5, Issue:14 Topics: Animals; Brain; Brain Chemistry; Cells, Cultured; Glycine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate	1994
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Molecular pharmacology, 1993, Volume: 44, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Brain; Electrophysiology; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis	1993
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro. Journal of neurochemistry, 1994, Volume: 62, Issue:5 Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium	1994
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo. European journal of pharmacology, 1994, Apr-01, Volume: 255, Issue:1-3 Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine	1994
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus	1996
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area	1996
Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds. Neurochemistry international, 1996, Volume: 29, Issue:5 Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dantrolene; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin	1996
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature medicine, 1996, Volume: 2, Issue:12 Topics: Animals; Anti-Bacterial Agents; Cochlea; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Hearing Tests; Kanamycin; Male; N-Methylaspartate; Neomycin; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1996
Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil. The Journal of physiology, 1996, Dec-01, Volume: 497 ( Pt 2) Topics: Age Factors; Animals; Dendrites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kinetics; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses	1996
Presynaptic control of subunit composition of NMDA receptors mediating synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Apr-15, Volume: 17, Issue:8 Topics: Animals; Bicuculline; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Macromolecular Substances; Magnesium; N-Methylaspartate; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Presynaptic Terminals; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses	1997
Ethanol specifically inhibits NMDA receptors with affinity for ifenprodil in the low micromolar range in cultured cerebellar granule cells. Journal of neurochemistry, 1997, Volume: 69, Issue:5 Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Piperidines; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate	1997
Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells. Journal of neurochemistry, 1997, Volume: 69, Issue:6 Topics: Animals; Calcium; Cell Line; Drug Combinations; Electric Conductivity; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Intracellular Membranes; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection	1997
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid. Brain research, 1997, Nov-28, Volume: 777, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides	1997
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. Journal of neurochemistry, 1998, Volume: 70, Issue:3 Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis	1998
Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons. Brain research. Molecular brain research, 1998, Jun-01, Volume: 57, Issue:1 Topics: Allosteric Site; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Ion Channel Gating; Kidney; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins	1998
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1) Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine	1998
Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-15, Volume: 18, Issue:24 Topics: Animals; Calcium Channels; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-6; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors	1998
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones. British journal of pharmacology, 1999, Volume: 126, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger	1999
Properties of NMDA receptors in rat spinal cord motoneurons. The European journal of neuroscience, 1999, Volume: 11, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord	1999
Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation. Journal of neurophysiology, 1999, Volume: 81, Issue:4 Topics: Animals; Biological Transport; Blotting, Western; Carrier Proteins; Cerebral Cortex; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Chloride Symporters; Staining and Labeling	1999
Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: Animals; Animals, Newborn; Cell Line; Cells, Cultured; Cerebellum; Drug Synergism; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection	1999
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection? The British journal of ophthalmology, 1999, Volume: 83, Issue:2 Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina	1999
Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum. The Journal of physiology, 2000, Apr-01, Volume: 524 Pt 1 Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Ethylenediamines; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses	2000
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil. Synapse (New York, N.Y.), 2000, Volume: 37, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine	2000
Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons. Journal of neuroscience research, 2000, Nov-01, Volume: 62, Issue:3 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Antagonists; Guanosine Triphosphate; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission	2000
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. Neuropharmacology, 2001, Volume: 40, Issue:2 Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord	2001
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition. Journal of neurochemistry, 2001, Volume: 76, Issue:1 Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc	2001
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex. Synapse (New York, N.Y.), 2001, Mar-15, Volume: 39, Issue:4 Topics: Animals; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kinetics; Male; N-Methylaspartate; Perfusion; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley	2001
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus. Journal of neuroendocrinology, 2001, Volume: 13, Issue:10 Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Desipramine; Excitatory Amino Acid Antagonists; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Tetrodotoxin	2001
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord. The European journal of neuroscience, 2001, Volume: 14, Issue:10 Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Nociceptors; Pain; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2001
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses. Neuron, 2002, Mar-14, Volume: 33, Issue:6 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine	2002
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:2 Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine	2002
Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature neuroscience, 2002, Volume: 5, Issue:9 Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Cells, Cultured; Endocytosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; N-Methylaspartate; Phosphoric Monoester Hydrolases; Piperidines; Protein Transport; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2002
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Neurochemistry international, 2003, Volume: 42, Issue:1 Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing	2003
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1 Topics: Anesthetics; Animals; Brain; Brain Chemistry; Cell Line; Central Nervous System Depressants; CHO Cells; Cricetinae; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ion Channel Gating; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pregnanediones; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	2003
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor. Journal of neurophysiology, 2003, Volume: 89, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Cells, Cultured; Conserved Sequence; DNA, Complementary; Electric Fish; Electric Organ; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kidney; Molecular Sequence Data; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection	2003
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Apr-15, Volume: 23, Issue:8 Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2003
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. European journal of pharmacology, 2003, Jun-20, Volume: 471, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2003
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-15, Volume: 23, Issue:12 Topics: Animals; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Synapses	2003
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging. Journal of neuroscience methods, 2003, Oct-15, Volume: 129, Issue:1 Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors	2003
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-12, Volume: 23, Issue:32 Topics: Amygdala; Animals; Down-Regulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; In Vitro Techniques; Male; Memory; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle	2003
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6 Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil	2003
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice. Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors	2004
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-08, Volume: 24, Issue:36 Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate	2004
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. Journal of neurophysiology, 2005, Volume: 94, Issue:1 Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Methylazoxymethanol Acetate; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Rats	2005
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Apr-20, Volume: 25, Issue:16 Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors	2005
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. Brain research, 2006, Feb-16, Volume: 1073-1074 Topics: Analysis of Variance; Animals; Auditory Cortex; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Infusion Pumps, Implantable; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors	2006
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11 Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine	2006
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor. Molecular and cellular neurosciences, 2006, Volume: 33, Issue:1 Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Targeting; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Motor Activity; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Xenopus laevis	2006
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology, 2007, Volume: 52, Issue:1 Topics: Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2007
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. Journal of neuroscience research, 2006, Nov-15, Volume: 84, Issue:7 Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Immunoglobulin G; In Vitro Techniques; Indole Alkaloids; Male; Membrane Potentials; N-Methylaspartate; Neurons; Optic Nerve; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus	2006
Glutamate exocytosis from astrocytes controls synaptic strength. Nature neuroscience, 2007, Volume: 10, Issue:3 Topics: Analysis of Variance; Animals; Astrocytes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	2007
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology, 2007, Volume: 53, Issue:1 Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mice; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors	2007
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus. Neuroscience, 2009, Mar-03, Volume: 159, Issue:1 Topics: Analysis of Variance; Animals; Biophysics; Drug Combinations; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2009
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:4 Topics: Animals; Antidepressive Agents; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamine; Lithium Chloride; Male; Mice; Models, Animal; Motor Activity; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Time Factors	2010
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology, 2009, Volume: 57, Issue:2 Topics: Amino Acid Sequence; Animals; Cell Line; Conotoxins; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Point Mutation; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins	2009
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience, 2010, Jan-20, Volume: 165, Issue:2 Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine	2010
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes	2010
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium. Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:10 Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate	2009
NMDA receptor contributions to visual contrast coding. Neuron, 2010, Jul-29, Volume: 67, Issue:2 Topics: Animals; Contrast Sensitivity; Dizocilpine Maleate; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Guinea Pigs; In Vitro Techniques; Light; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Photic Stimulation; Piperidines; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Visual Perception	2010
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry, 2011, Volume: 117, Issue:3 Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium	2011
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron, 2011, Apr-28, Volume: 70, Issue:2 Topics: Adaptation, Physiological; Animals; Animals, Newborn; Electric Stimulation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Knockout; Models, Biological; N-Methylaspartate; Piperidines; Pyramidal Cells; Pyridines; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Thiazoles; Time Factors; Visual Cortex	2011
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice. Journal of neuroscience research, 2011, Volume: 89, Issue:11 Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Mice; N-Methylaspartate; Pain Measurement; Phosphorylation; Piperidines; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synapses	2011
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-03, Volume: 31, Issue:31 Topics: Action Potentials; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain Waves; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electroencephalography; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Flavones; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Piperazines; Piperidines; Pregnanolone; Presenilin-1; Receptors, N-Methyl-D-Aspartate; Serotonin; Sodium Channel Blockers; Synapses; Tetrodotoxin	2011
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists. Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19 Topics: Amino Alcohols; Binding Sites; Dizocilpine Maleate; Drug Design; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Ligands; Molecular Structure; Molecular Targeted Therapy; N-Methylaspartate; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism	2011
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes. Journal of neurochemistry, 2011, Volume: 119, Issue:4 Topics: Animals; Area Under Curve; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Interleukin-1beta; Lipopolysaccharides; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Exchanging ATPase	2011
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. PloS one, 2011, Volume: 6, Issue:9 Topics: Amygdala; Animals; Conditioning, Psychological; Cysteine Proteinase Inhibitors; DNA Helicases; Excitatory Amino Acid Antagonists; Fear; Immunoblotting; Lactones; Male; Memory; Memory, Long-Term; N-Methylaspartate; Neuronal Plasticity; Piperidines; Proteasome Endopeptidase Complex; Proteolysis; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors; Ubiquitin; Ubiquitination	2011
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons. Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:2 Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate	2012
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. Brain research bulletin, 2012, Sep-01, Volume: 88, Issue:6 Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Membrane; Creatine; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoenzymes; Male; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase	2012
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. Neuropharmacology, 2012, Volume: 63, Issue:6 Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger	2012
Synthesis and in vitro characterisation of ifenprodil-based fluorescein conjugates as GluN1/GluN2B N-Methyl-D-aspartate receptor antagonists. Chembiochem : a European journal of chemical biology, 2013, Apr-15, Volume: 14, Issue:6 Topics: Animals; Binding Sites; Brain; Calcium; Cells, Cultured; Fluorescein; HEK293 Cells; Humans; Male; Mice; Models, Molecular; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Radiography; Receptors, N-Methyl-D-Aspartate	2013
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behavioural brain research, 2013, Aug-01, Volume: 250 Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation	2013
D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent. CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:11 Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine	2014
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:9 Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine	2015
Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015, Jul-05, Volume: 370, Issue:1672 Topics: Animals; Dendrites; Diazonium Compounds; Glutamic Acid; Mice; N-Methylaspartate; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials	2015
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse (New York, N.Y.), 2016, Volume: 70, Issue:1 Topics: Animals; Carrier Proteins; Cells, Cultured; Central Nervous System Depressants; Electric Capacitance; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Homer Scaffolding Proteins; Kainic Acid; Membrane Potentials; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate	2016
Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity. Journal of Alzheimer's disease : JAD, 2017, Volume: 57, Issue:3 Topics: Amyloid beta-Peptides; Animals; Antimetabolites; Cycloserine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Locomotion; Male; Maze Learning; N-Methylaspartate; Nesting Behavior; Neurotoxicity Syndromes; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Signal Transduction; Synapses	2017
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility. Neurobiology of disease, 2017, Volume: 106 Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques	2017
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex. Neuropharmacology, 2018, Volume: 128 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclin-Dependent Kinase 5; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Neurons; Phosphopyruvate Hydratase; Piperidines; Pyridazines; Sensory Deprivation; Visual Cortex; Visual Pathways	2018